MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria
Chi Ying Gary Ding
Li Mei Pang
Zhao-Xun Liang
Kau Kiat Kelvin Goh
Evgenia Glukhov
William Gerwick
Lik Tong Tan
Marine Drugs, 2018-12
Gary Ding
Ding Gary
/ Ding Chi Ying Gary
ORCID: 0000-0002-5973-9235
Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides
10.1021/acs.jnatprod.9b00675
MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria
10.3390/md16120505
Benderamide A, a Cyclic Depsipeptide from a Singapore Collection of Marine Cyanobacterium cf. Lyngbya sp.
10.3390/md16110409
Zhao-Xun Liang
Liang Zhao-Xun
ORCID: 0000-0002-3128-1330
Solution structure of the PAS domain of a thermophilic YybT protein homolog reveals a potential ligand-binding site
10.1074/jbc.M112.437764
Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
10.1107/S0907444912047269
Visualizing the perturbation of cellular cyclic di-GMP levels in bacterial cells
10.1021/ja310497x
Functional divergence of FimX in PilZ Binding and type IV Pilus regulation
10.1128/JB.00767-12
Rigidifying acyl carrier protein domain in iterative type i PKS CalE8 does not affect its function
10.1016/j.bpj.2012.08.006
Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling
10.1128/JB.00560-12
Synthesis of (R)-mellein by a partially reducing iterative polyketide synthase
10.1021/ja304905e
Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis
10.1074/jbc.M112.362210
Rational design of fluorescent biosensor for cyclic di-GMP
10.1002/cbic.201100557
The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP) 2 at the active site
10.1107/S090744491104039X
YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity (Journal of Biological Chemistry (2010) 285, (473-482))
10.1074/jbc.A109.040238
MrKH, a novel c-di-GMP-dependent transcriptional activator, controls klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression
10.1371/journal.ppat.1002204
Solution structures of the Acyl carrier protein domain from the highly reducing type I iterative polyketide synthase CalE8
10.1371/journal.pone.0020549
Unusual heme-binding PAS domain from YybT family proteins
10.1128/JB.01364-10
Binding of cyclic diguanylate in the non-catalytic EAL domain of FimX induces a long-range conformational change
10.1074/jbc.M110.196220
Induced-fit upon Ligand Binding Revealed by Crystal Structures of the Hot-dog Fold Thioesterase in Dynemicin Biosynthesis
10.1016/j.jmb.2010.09.041
Complexity and simplicity in the biosynthesis of enediyne natural products
10.1039/b908165h
YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity
10.1074/jbc.M109.040238
Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis
10.1039/b916751j
A flavin cofactor-binding PAS domain regulates c-di-GMP synthesis in AxDGC2 from Acetobacter xylinum
10.1021/bi901121w
The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase
10.1128/JB.00327-09
Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase
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10.1021/ja8019643
Catalytic mechanism of cyclic di-GMP-specific phosphodiesterase: A study of the EAL domain-containing RocR from Pseudomonas aeruginosa
10.1128/JB.00165-08
Evidence for a novel phosphopantetheinyl transferase domain in the polyketide synthase for enediyne biosynthesis
10.1016/j.febslet.2008.02.061
Structural bases of hydrogen tunneling in enzymes: Progress and puzzles
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Evidence for increased local flexibility in psychrophilic alcohol dehydrogenase relative to its thermophilic homologue
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Impact of protein flexibility on hydride-transfer parameters in thermophilic and psychrophilic alcohol dehydrogenases
10.1021/ja047087z
Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase
10.1073/pnas.0403337101
Crystal Structure and Amide H/D Exchange of Binary Complexes of Alcohol Dehydrogenase from Bacillus stearothermophilus: Insight into Thermostability and Cofactor Binding
10.1021/bi049736p
Dynamic Docking and Electron-Transfer between Cytochrome b5 and a Suite of Myoglobin Surface-Charge Mutants. Introduction of a Functional-Docking Algorithm for Protein-Protein Complexes
10.1021/ja038163l
Dynamic docking and electron transfer between myoglobin and cytochrome b5
10.1007/s00775-001-0332-0
Dynamic docking and electron transfer between Zn-myoglobin and cytochrome b5
10.1021/ja0127032
Photoinduced electron transfer in a supramolecular species building of mono-6-p-nitrobenzoyl-β-cyclodextrin with naphthalene derivatives
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A study on the laser flash photolysis of phenothiazine and its N-alkyl derivatives
10.1016/1010-6030(95)04148-6
The expanding roles of c-di-GMP in the biosynthesis of exopolysaccharides and secondary metabolites
10.1039/c4np00086b
Structure of a diguanylate cyclase from thermotoga maritima: Insights into activation, feedback inhibition and thermostability
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Finally! The structural secrets of a HD-GYP phosphodiesterase revealed
10.1111/mmi.12463
Nitrile reductase as a biocatalyst: Opportunities and challenges
10.1039/c4cy00646a
Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA-RCK
10.1021/acs.biochem.5b00633
Cyclic-di-AMP synthesis by the diadenylate cyclase CdaA is modulated by the peptidoglycan biosynthesis enzyme GlmM in lactococcus lactis
10.1111/mmi.13281
Insights into the programmed ketoreduction of partially reducing polyketide synthases: Stereo- and substrate-specificity of the ketoreductase domain
10.1039/c4ob01777c
Insight into enzymatic nitrile reduction: QM/MM study of the catalytic mechanism of QueF nitrile reductase
10.1021/acscatal.5b00528
The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in Salmonella typhimurium
10.1111/mmi.12428
A cyclic di-GMP-binding adaptor protein interacts with histidine kinase to regulate two-component signaling
10.1074/jbc.M116.730887
Replenishing the cyclic-di-AMP pool: regulation of diadenylate cyclase activity in bacteria
10.1007/s00294-016-0600-8
Progress in Understanding the Molecular Basis Underlying Functional Diversification of Cyclic Dinucleotide Turnover Proteins
10.1128/JB.00790-16
A cyclic di-GMP-binding adaptor protein interacts with a chemotaxis methyltransferase to control flagellar motor switching
10.1126/scisignal.aaf7584
Sequencing and functional annotation of the whole genome of the filamentous fungus Aspergillus westerdijkiae
10.1186/s12864-016-2974-x
Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa
10.1128/JB.00515-17
Emerging paradigms for PilZ domain-mediated C-di-GMP signaling
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Regulation of flagellar motor switching by c-di-GMP phosphodiesterases in Pseudomonas aeruginosa
10.1074/jbc.RA119.009009
The MapZ-Mediated Methylation of Chemoreceptors Contributes to Pathogenicity of Pseudomonas aeruginosa
10.3389/fmicb.2019.00067
Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant.
10.1371/journal.pgen.1007574
Identification of a biosynthetic gene cluster for the polyene macrolactam sceliphrolactam in a Streptomyces strain isolated from mangrove sediment.
10.1038/s41598-018-20018-8
Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein.
10.1074/jbc.M117.815704
Enzymatic Production of c-di-GMP Using a Thermophilic Diguanylate Cyclase.
10.1007/978-1-4939-7240-1_2
Large-scale sequence similarity analysis reveals the scope of sequence and function divergence in PilZ domain proteins
10.1101/2020.02.11.943704
Sungeidines from a Non-canonical Enediyne Biosynthetic Pathway
10.1021/jacs.9b10086
Multifunctional Antimicrobial Nanofiber Dressings Containing ε-Polylysine for the Eradication of Bacterial Bioburden and Promotion of Wound Healing in Critically Colonized Wounds
10.1021/acsami.9b21683
Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin
10.1039/c9cc08908j
Integrated Genomic and Metabolomic Approach to the Discovery of Potential Anti-Quorum Sensing Natural Products from Microbes Associated with Marine Samples from Singapore
10.3390/md17010072
MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria
10.3390/md16120505
Taming the flagellar motor of pseudomonads with a nucleotide messenger
10.1111/1462-2920.15036
Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis
10.1128/mBio.00324-21
Pathway Retrofitting Yields Insights into the Biosynthesis of Anthraquinone-Fused Enediynes
10.1021/jacs.1c03911
William Gerwick
Gerwick William
ORCID: 0000-0003-1403-4458
Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata
10.3390/md15040121
Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group
10.3390/md16050163
Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease
10.3390/molecules23061472
MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria
10.3390/md16120505
Integrated Genomic and Metabolomic Approach to the Discovery of Potential Anti-Quorum Sensing Natural Products from Microbes Associated with Marine Samples from Singapore
10.3390/md17010072
Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke
10.3390/md18070374
A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria
10.3390/md19010020
Kalkitoxin Reduces Osteoclast Formation and Resorption and Protects against Inflammatory Bone Loss
10.3390/ijms22052303
Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens
10.1021/acs.jnatprod.7b00034
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
10.1021/acs.jmedchem.7b00671
5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34
10.3390/md15080260
The Face of a Molecule
10.1021/acs.jnatprod.7b00624
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research
10.1038/s41598-017-13923-x
A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit
10.1021/acschembio.7b00746
Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group
10.1021/acs.jnatprod.7b00917
Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp.
10.1021/acs.joc.8b00028
Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β
10.1021/acschemneuro.7b00527
Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module
10.1021/acschembio.8b00252
Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta
10.1021/acschembio.8b00910
Structural Basis of Polyketide Synthase O-Methylation
10.1021/acschembio.8b00687
Dragocins A−D, Structurally Intriguing Cytotoxic Metabolites from a Panamanian Marine Cyanobacterium
10.1021/acs.orglett.8b03712
Marine natural products as potential anti-tubercular agents
10.1016/j.ejmech.2019.01.026
Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp.
10.1021/acs.orglett.8b04050
Nature's Combinatorial Biosynthesis Produces Vatiamides A–F
10.1002/anie.201902571
Nature's Combinatorial Biosynthesis Produces Vatiamides A–F
10.1002/ange.201902571
Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens
10.1021/acs.jnatprod.9b00549
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain
10.1021/acs.jmedchem.9b00294
Commensal oralRothia mucilaginosaproduces enterobactin – a metal chelating siderophore
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Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity
10.3390/molecules25071604
Commensal Oral Rothia mucilaginosa Produces Enterobactin, a Metal-Chelating Siderophore
10.1128/mSystems.00161-20
Correction to “Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp.”
10.1021/acs.orglett.0c02252
The Chemistry, Biochemistry and Pharmacology of Marine Natural Products from Leptolyngbya, a Chemically Endowed Genus of Cyanobacteria
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Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2
10.1021/acs.jnatprod.0c00968
Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A
10.1021/acs.jnatprod.0c01317
Cyanobacteria-shrimp colonies in the Mariana Islands
10.1007/s10452-021-09837-6
Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium
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SIRT1 Activation Enhancing 8,3′-Neolignans from the Twigs of Corylopsis coreana Uyeki
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First Total Synthesis and Structure–Activity Relationship of Iheyamide A, an Antitrypanosomal Linear Peptide Isolated from a Dapis sp. Marine Cyanobacterium
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