Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria
Raze D Verwaerde C Deloison G Werkmeister E Coupin B Loyens M Brodin P Rouanet C Locht C
Camille Locht
Locht Camille
ORCID: 0000-0001-7295-7336
HBHA-Induced Polycytotoxic CD4+ T Lymphocytes Are Associated with the Control of Mycobacterium tuberculosis Infection in Humans 10.4049/jimmunol.1800840
Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS 10.1371/journal.pone.0204861
Non-specific Effects of Live Attenuated Pertussis Vaccine Against Heterologous Infectious and Inflammatory Diseases 10.3389/fimmu.2018.02872
IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine 10.1038/s41385-018-0073-9
Rv0613c/MSMEG_1285 Interacts with HBHA and Mediates Its Proper Cell-Surface Exposure in Mycobacteria 10.3390/ijms19061673
Tuberculin skin test reaction is related to memory, but not naive CD4+ T cell responses to mycobacterial stimuli in BCG-vaccinated young adults 10.1016/j.vaccine.2018.05.068
Diversion of complement-mediated killing by Bordetella 10.1016/j.micinf.2018.02.002
TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development 10.3389/fimmu.2017.01203
Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis 10.1371/journal.pone.0176396
Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258
In vivo imaging of bacterial colonization of the lower respiratory tract in a baboon model of Bordetella pertussis infection and transmission 10.1038/s41598-018-30896-7
Primary transcriptome analysis reveals importance of IS elements for the shaping of the transcriptional landscape of Bordetella pertussis 10.1080/15476286.2018.1462655
Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor 10.1038/s41426-018-0039-8
Construction and evaluation of Bordetella pertussis live attenuated vaccine strain BPZE1 producing Fim3 10.1016/j.vaccine.2018.02.017
Will we have new pertussis vaccines? 10.1016/j.vaccine.2017.11.055
Assessing the reactogenicity of Tdap vaccine administered during pregnancy and antibodies to Bordetella pertussis antigens in maternal and cord sera of Thai women 10.1016/j.vaccine.2018.01.059
Conformational Changes of an Interdomain Linker Mediate Mechanical Signal Transmission in Sensor Kinase BvgS 10.1128/JB.00114-17
Coiled-Coil Antagonism Regulates Activity of Venus Flytrap-Domain-Containing Sensor Kinases of the BvgS Family 10.1128/mBio.02052-17
The Role of Mucosal Immunity in Pertussis 10.3389/fimmu.2018.03068
Live Attenuated Pertussis Vaccine BPZE1 Protects Baboons Against Bordetella pertussis Disease and Infection 10.1093/infdis/jix254
BCG and protection against inflammatory and auto-immune diseases 10.1080/14760584.2017.1333906
Age-Stratified T Cell Responses in Children Infected with Mycobacterium tuberculosis 10.3389/fimmu.2017.01059
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006
Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development 10.1128/CVI.00388-16
Erratum for Carbonetti et al., "Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development" 10.1128/CVI.00071-17
Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis 10.15252/emmm.201606330
Live pertussis vaccines: will they protect against carriage and spread of pertussis? 10.1016/j.cmi.2016.05.029
The multifaceted RisA regulon of Bordetella pertussis 10.1038/srep32774
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619
Added Value of Long-Term Cytokine Release Assays to Detect Mycobacterium tuberculosis Infection in HIV-Infected Subjects in Uganda 10.1097/QAI.0000000000000980
[Tuberculosis, a story still relevant] 10.1051/medsci/20163206001
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297
Pertussis: Where did we go wrong and what can we do about it? 10.1016/j.jinf.2016.04.020
Pertussis: acellular, whole-cell, new vaccines, what to choose? 10.1586/14760584.2016.1161511
Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella 10.1128/mBio.02089-15
Reciprocal interference of maternal and infant immunization in protection against pertussis 10.1016/j.vaccine.2016.01.011
Signal transduction by BvgS sensor kinase. Binding of modulator nicotinate affects the conformation and dynamics of the entire periplasmic moiety 10.1074/jbc.A115.655720
Integrating knowledge of Mycobacterium tuberculosis pathogenesis for the design of better vaccines 10.1586/14760584.2015.1102638
Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults 10.1155/2015/359153
Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome 10.1371/journal.pone.0133924
Dynamic interplay of membrane-proximal POTRA domain and conserved loop L6 in Omp85 transporter FhaC 10.1111/mmi.13137
Signal Transduction by BvgS Sensor Kinase: BINDING OF MODULATOR NICOTINATE AFFECTS THE CONFORMATION AND DYNAMICS OF THE ENTIRE PERIPLASMIC MOIETY 10.1074/jbc.M115.655720
Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS 10.1371/journal.ppat.1004700
Investigating pertussis toxin and its impact on vaccination 10.2217/fmb.14.123
Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: comparison with the tuberculin skin test and the QuantiFERON-TB Gold In-tube 10.1186/s12879-015-0796-0
Early cellular immune response to a new candidate mycobacterial vaccine antigen in childhood tuberculosis 10.1016/j.vaccine.2014.12.011
Unconventional, adenosine-producing suppressor T cells induced by dendritic cells exposed to BPZE1 pertussis vaccine 10.1189/jlb.3a0315-101r
Translocation path of a substrate protein through its Omp85 transporter 10.1038/ncomms6271
Antigen-specific interferon-gamma responses and innate cytokine balance in TB-IRIS 10.1371/journal.pone.0113101
HBHA vaccination may require both Th1 and Th17 immune responses to protect mice against tuberculosis 10.1016/j.vaccine.2014.09.024
Toward Understanding the Essence of Post-Translational Modifications for the Mycobacterium tuberculosis Immunoproteome 10.3389/fimmu.2014.00361
Live attenuated B. pertussis BPZE1 rescues the immune functions of Respiratory Syncytial virus infected human dendritic cells by promoting Th1/Th17 responses 10.1371/journal.pone.0100166
Live attenuated vaccines against pertussis 10.1586/14760584.2014.942222
Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin 10.1016/j.micinf.2014.04.003
Conformational dynamics of protein transporter FhaC: large-scale motions of plug helix 10.1111/mmi.12585
B-cell responses after intranasal vaccination with the novel attenuated Bordetella pertussis vaccine strain BPZE1 in a randomized phase I clinical trial 10.1016/j.vaccine.2014.04.048
Possible options for new pertussis vaccines 10.1093/infdis/jit531
A phase I clinical study of a live attenuated Bordetella pertussis vaccine--BPZE1; a single centre, double-blind, placebo-controlled, dose-escalating study of BPZE1 given intranasally to healthy adult male volunteers 10.1371/journal.pone.0083449
Mucosal delivery of antigen-coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice 10.1002/eji.201343887
Pertussis toxin improves immune responses to a combined pneumococcal antigen and leads to enhanced protection against Streptococcus pneumoniae 10.1128/CVI.00134-14
Heterologous prime-boost immunization with live attenuated B. pertussis BPZE1 followed by acellular pertussis vaccine in mice 10.1016/j.vaccine.2014.06.019
Key role of effector memory CD4+ T lymphocytes in a short-incubation heparin-binding hemagglutinin gamma interferon release assay for the detection of latent tuberculosis 10.1128/CVI.00651-13
LPS-binding protein and IL-6 mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients 10.1371/journal.pone.0081856
Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism 10.1164/rccm.201307-1227OC
Protective role of adenylate cyclase in the context of a live pertussis vaccine candidate 10.1016/j.micinf.2013.10.002
Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination 10.1016/j.vaccine.2013.10.056
Heparin-binding haemagglutinin, a new tool for the detection of latent Mycobacterium tuberculosis infection in hemodialysis patients 10.1371/journal.pone.0071088
Novel feature of Mycobacterium avium subsp. paratuberculosis, highlighted by characterization of the heparin-binding hemagglutinin adhesin 10.1128/JB.00671-13
Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission 10.1186/1471-2180-13-172
Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome 10.1097/qad.0b013e328361648b
The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome 10.1016/j.imbio.2013.07.004
Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e 10.1371/journal.pone.0059198
Purification of native HBHA from Mycobacterium avium subsp. paratuberculosis 10.1186/1756-0500-6-55
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis 10.1038/ng.2517
Persistence at one year of age of antigen-induced cellular immune responses in preterm infants vaccinated against whooping cough: comparison of three different vaccines and effect of a booster dose 10.1016/j.vaccine.2013.02.004
Low prevalence of vitamin D deficiency in Ugandan HIV-infected patients with and without tuberculosis 10.5588/ijtld.11.0146
Broad heparin-binding haemagglutinin-specific cytokine and chemokine response in infants following Mycobacterium bovis BCG vaccination 10.1002/eji.201142297
Risk stratification of latent tuberculosis defined by combined interferon gamma release assays 10.1371/journal.pone.0043285
Attenuated Bordetella pertussis BPZE1 protects against allergic airway inflammation and contact dermatitis in mouse models 10.1111/j.1398-9995.2012.02884.x
Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice 10.1016/j.vaccine.2012.07.005
New pertussis vaccination approaches: en route to protect newborns? 10.1111/j.1574-695x.2012.00988.x
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis 10.1021/jm300377g
Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis 10.1371/journal.pone.0032421
Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection 10.3851/imp2108
Both CD4⁺ and CD8⁺ lymphocytes participate in the IFN-γ response to filamentous hemagglutinin from Bordetella pertussis in infants, children, and adults 10.1155/2012/795958
Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands 10.1093/nar/gkr1113
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors 10.1021/jm200825u
The ins and outs of pertussis toxin 10.1111/j.1742-4658.2011.08237.x
Urinary lipoarabinomannan as predictor for the tuberculosis immune reconstitution inflammatory syndrome 10.1097/qai.0b013e31823801de
Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy 10.1097/qai.0b013e3182255dc2
[New antituberculosis vaccines] 10.1016/j.arcped.2011.05.003
Development of live attenuated Bordetella pertussis strains expressing the universal influenza vaccine candidate M2e 10.1016/j.vaccine.2011.05.052
Recombinant HBHA boosting effect on BCG-induced immunity against Mycobacterium tuberculosis infection 10.1155/2011/730702
Substrate recognition by the POTRA domains of TpsB transporter FhaC 10.1111/j.1365-2958.2011.07680.x
Membrane-associated DegP in Bordetella chaperones a repeat-rich secretory protein 10.1111/j.1365-2958.2011.07672.x
Detection of small RNAs in Bordetella pertussis and identification of a novel repeated genetic element 10.1186/1471-2164-12-207
The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country 10.1371/journal.pone.0018256
Attenuated Bordetella pertussis vaccine candidate BPZE1 promotes human dendritic cell CCL21-induced migration and drives a Th1/Th17 response 10.4049/jimmunol.1003765
Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors 10.1021/jm200076a
Characterization of the Mycobacterium avium subsp. paratuberculosis laminin-binding/histone-like protein (Lbp/Hlp) which reacts with sera from patients with Crohn's disease 10.1016/j.micinf.2011.02.002
Chips from chips: application to the study of antibody responses to methylated proteins 10.1021/pr100707t
Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator 10.1021/cb100177g
Functional importance of a conserved sequence motif in FhaC, a prototypic member of the TpsB/Omp85 superfamily 10.1111/j.1742-4658.2010.07881.x
Long-term immunity against pertussis induced by a single nasal administration of live attenuated B. pertussis BPZE1 10.1016/j.vaccine.2010.08.017
Report of the 2nd "French Clinical Vaccinology Meeting Jean-Gerard Guillet": immunization and respiratory diseases 10.1016/j.vaccine.2010.07.038
Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism 10.1073/pnas.1006267107
Boosting BCG to protect against TB 10.1586/ers.10.25
Attenuated Bordetella pertussis protects against highly pathogenic influenza A viruses by dampening the cytokine storm 10.1128/JVI.02542-09
Boosting with mycobacterial heparin-binding haemagglutinin enhances protection of Mycobacterium bovis BCG-vaccinated newborn mice against M. tuberculosis 10.1016/j.vaccine.2010.04.062
T- and B-cell-mediated protection induced by novel, live attenuated pertussis vaccine in mice. Cross protection against parapertussis 10.1371/journal.pone.0010178
Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model 10.1111/j.1365-2222.2010.03459.x
Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans 10.1164/rccm.201001-0083oc
Impact of HIV infection on the recurrence of tuberculosis in South India 10.1086/650528
Dose response of attenuated Bordetella pertussis BPZE1-induced protection in mice 10.1128/CVI.00322-09
Cellular immune responses of preterm infants after vaccination with whole-cell or acellular pertussis vaccines 10.1128/CVI.00328-09
Correction: Molecular Evolution of the Two-Component System BvgAS Involved in Virulence Regulation in Bordetella 10.1371/annotation/ae7f86ff-0aca-4411-aed3-3eeea9303abb
Monocyte-derived interleukin-10 depresses the Bordetella pertussis- specific gamma interferon response in vaccinated infants 10.1128/CVI.00314-09
In situ chemical modification of peptide microarrays: application to the study of the antibody responses to methylated antigens 10.1007/978-1-60761-845-4_11
Molecular evolution of the two-component system BvgAS involved in virulence regulation in Bordetella 10.1371/journal.pone.0006996
Role of DegP for two-partner secretion in Bordetella 10.1111/j.1365-2958.2009.06860.x
Cytokine and antibody profiles in 1-year-old children vaccinated with either acellular or whole-cell pertussis vaccine during infancy 10.1016/j.vaccine.2009.07.075
Genomic island excisions in Bordetella petrii 10.1186/1471-2180-9-141
Subcutaneous boosting with heparin binding haemagglutinin increases BCG-induced protection against tuberculosis 10.1016/j.micinf.2009.07.005
Synthetic EthR inhibitors boost antituberculous activity of ethionamide 10.1038/nm.1950
A live attenuated Bordetella pertussis candidate vaccine does not cause disseminating infection in gamma interferon receptor knockout mice 10.1128/CVI.00082-09
Biomarkers for tuberculosis disease status and diagnosis 10.1097/mcp.0b013e328326f42c
Interaction of the mycobacterial heparin-binding hemagglutinin with actin, as evidenced by single-molecule force spectroscopy 10.1128/JB.00974-08
Origin, spread and demography of the Mycobacterium tuberculosis complex 10.1371/journal.ppat.1000160
Genetic stability of the live attenuated Bordetella pertussis vaccine candidate BPZE1 10.1016/j.vaccine.2008.08.018
The coiled-coil N-terminal domain of the heparin-binding haemagglutinin is required for the humoral and cellular immune responses in mice 10.1016/j.molimm.2008.07.009
Bordetella pertussis filamentous hemagglutinin delivered by mucosal routes enhances immunoglobulin levels in serum and mucosal fluids 10.1111/j.1574-695x.2008.00460.x
A common vaccination strategy to solve unsolved problems of tuberculosis and pertussis? 10.1016/j.micinf.2008.07.008
How a different look at latency can help to develop novel diagnostics and vaccines against tuberculosis 10.1517/14712598.7.11.1665
The peptidyl-prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulins 10.1016/j.jmb.2007.10.088
Highly attenuated Bordetella pertussis strain BPZE1 as a potential live vehicle for delivery of heterologous vaccine candidates 10.1128/IAI.00795-07
Structure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug family 10.1016/j.jmb.2007.08.006
Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis 10.1371/journal.pone.0000926
Single-molecule force spectroscopy of mycobacterial adhesin-adhesin interactions 10.1128/JB.01299-07
Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily 10.1126/science.1143860
In vitro expansion of CD4+CD25highFOXP3+CD127low/- regulatory T cells from peripheral blood lymphocytes of healthy Mycobacterium tuberculosis-infected humans 10.1016/j.micinf.2007.06.004
Regulatory T cells depress immune responses to protective antigens in active tuberculosis 10.1164/rccm.200701-084oc
Macrophage-specific Mycobacterium tuberculosis genes: identification by green fluorescent protein and kanamycin resistance selection 10.1099/mic.0.2006/000547-0
Enzymatic methylation of the Mycobacterium tuberculosis heparin-binding haemagglutinin 10.1111/j.1574-6968.2007.00636.x
Crystal structures of two Bordetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamily 10.1016/j.jmb.2007.04.047
IL-18 does not increase allergic airway disease in mice when produced by BCG 10.1155/2007/67276
Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis 10.1080/00365540701402954
Mycobacterium smegmatis produces an HBHA homologue which is not involved in epithelial adherence 10.1016/j.micinf.2006.11.007
Combined RNAseq and ChIPseq Analyses of the BvgA Virulence Regulator of Bordetella pertussis 10.1128/mSystems.00208-20
Good old BCG – what a century‐old vaccine can contribute to modern medicine 10.1111/joim.13195
The History of Pertussis Toxin 10.3390/toxins13090623
Priscille Brodin
Brodin Priscille
ORCID: 0000-0003-0991-7344
Email: priscille.brodin@inserm.fr
How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011
Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227 10.3390/toxins9070227.
Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections 10.2217/nnm-2016-0364
Cyclodextrin-based nanocarriers containing a synergic drug combination: a potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030 10.1016/j.ijpharm.2017.05.030.
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z
Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005 10.1016/j.drudis.2017.05.005.
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535
Impact of pe_ pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis 10.3389/fcimb.2017.00137
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129 10.1002/cyto.a.23129.
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5
Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization 10.1016/j.str.2016.07.009
Mycolactone The amazing analgesic mycobacterial toxin 10.1051/medsci/20163202007
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650
High content screening in chemical biology: overview and main challenges 10.1051/medsci/20153102016
High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis 10.1128/aac.03705-14
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438
Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15
Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays 10.1007/978-1-4939-2450-9_24
A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening 10.3791/51114
Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/jm500422b
Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040
Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022
A novel specific edge effect correction method for RNA interference screenings 10.1093/bioinformatics/btr648
Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779
Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u
The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence 10.1371/journal.pone.0047573
Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis 10.1371/journal.pone.0026675
Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200076a
High-content screening in infectious diseases 10.1016/j.cbpa.2011.05.023
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ 10.1099/mic.0.038133-0
High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100
High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery 10.4155/fmc.10.223
Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting 10.1016/j.biomaterials.2009.09.044
Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure 10.1177/1087057108328762
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis 10.1126/science.1171583
High Content Screening Identifies Decaprenyl-Phosphoribose 2 ' Epimerase as a Target for Intracellular Antimycobacterial Inhibitors 10.1371/journal.ppat.1000645
Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507
Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033
Aquatic insects and transmission of Mycobacterium ulcerans 10.1051/medsci/20072367572
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 10.1128/jb.00469-07
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis 10.1371/journal.ppat.0030062
Protection against mycobacterium ulcerans lesion development by exposure to aquatic insect saliva 10.1371/journal.pmed.0040064
Support vector machines for automatic detection of tuberculosis bacteria in confocal microscopy images 10.1109/isbi.2007.356794
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues 10.1016/j.bmc.2006.12.009
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis 10.1128/iai.74.4.2128-2137.2006
Benzofuro 3,2-f 1 benzopyrans: A new class of antitubercular agents 10.1016/j.bmc.2006.03.033
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/iai.74.1.88-98.2006
High frequency of CD4(+) T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection 10.1128/iai.02086-05
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence 10.1128/jb.00631-06
Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis 10.1016/j.tube.2004.09.009
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200
Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics 10.1099/mic.0.27799-0
Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions 10.1016/j.jmb.2005.05.049
Tuberculosis: from genome to vaccine 10.1586/14760584.4.4.541
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6 10.1128/iai.72.4.2170-2176.2004
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468
ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex 10.1099/mic.0.26662-0
CD8(+)-T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family 10.1128/iai.71.12.7173-7177.2003
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/nm859
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant 10.1128/iai.70.10.5568-5578.2002
Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides 10.1021/bi015732y
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x
6-Oxocytidine containing oligonucleotides inhibit the HIV-1 integrase in vitro 10.1081/ncn-100002322
Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase 10.1021/bi000398b
Inhibition of the human immunodeficiency virus type 1 DNA integration by modified oligonucleotides 10.1023/a:1026631910681
Branched oligonucleotide-intercalator conjugate forming a parallel stranded structure inhibits HIV-1 integrase 10.1016/s0014-5793(99)01350-2
Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides 10.1080/07328319908044831
Optimization of alternate-strand triple helix formation at the 5 '-TpA-3 ' and 5 '-ApT-3 ' junctions 10.1093/nar/27.15.3029
A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus 10.1074/jbc.272.25.16010
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371 10.15252/embr.201744371.
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017 10.1016/j.mib.2017.11.017.
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101 10.1016/j.celrep.2017.08.101.
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114 10.1073/pnas.1707840114.
Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry 10.1128/jvi.01982-17
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025
Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation 10.3389/fimmu.2018.00086
Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis 10.1128/aac.00359-18
The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129
A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening 10.1002/cyto.a.20627
Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation 10.1074/mcp.RA119.001316
Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902
Mitochondrial Dynamics and Activity in Legionella-Infected Cells 10.1007/978-1-4939-9048-1_13
Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258
Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication 10.1128/jvi.02009-18
A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J
Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls 10.3390/toxins11090516
Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies. 10.3389/fimmu.2020.569127
Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity. 10.1021/acsinfecdis.9b00277
Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds. 10.1371/journal.pone.0227224
Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis. 10.1016/j.vaccine.2019.11.085
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551
Worms' Antimicrobial Peptides. 10.3390/md17090512
Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. 10.1371/journal.pone.0198226
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570
Cell microbiology interview 10.1111/cmi.13288
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505
Dominique Raze
Raze Dominique
ORCID: 0000-0001-5836-063X
HBHA vaccination may require both Th1 and Th17 immune responses to protect mice against tuberculosis 10.1016/j.vaccine.2014.09.024
Optimization of standard 24-locus variable-number tandem-repeat typing of Mycobacterium tuberculosis isolates: a multicenter perspective. 10.1128/jcm.01790-14
Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism. 10.1164/rccm.201307-1227oc
Novel feature of Mycobacterium avium subsp. paratuberculosis, highlighted by characterization of the heparin-binding hemagglutinin adhesin. 10.1128/jb.00671-13
Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e 10.1371/journal.pone.0059198
Purification of native HBHA from Mycobacterium avium subsp. paratuberculosis 10.1186/1756-0500-6-55
Mycobacterial laminin-binding histone-like protein mediates collagen-dependent cytoadherence. 10.1590/s0074-02762012000900025
Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice 10.1016/j.vaccine.2012.07.005
Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis 10.1371/journal.pone.0032421
Characterization of the Mycobacterium avium subsp. paratuberculosis laminin-binding/histone-like protein (Lbp/Hlp) which reacts with sera from patients with Crohn's disease 10.1016/j.micinf.2011.02.002
Force spectroscopy of the interaction between mycobacterial adhesins and heparan sulphate proteoglycan receptors 10.1002/cphc.200900208
Interaction of the mycobacterial heparin-binding hemagglutinin with actin, as evidenced by single-molecule force spectroscopy. 10.1128/jb.00974-08
Genetic stability of the live attenuated Bordetella pertussis vaccine candidate BPZE1 10.1016/j.vaccine.2008.08.018
In vivo effect of adhesion inhibitor heparin on Legionella pneumophila pathogenesis in a murine pneumonia model 10.1007/s00134-008-1063-2
Organization of the mycobacterial cell wall: a nanoscale view 10.1007/s00424-007-0386-0
Single-molecule force spectroscopy of mycobacterial adhesin-adhesin interactions. 10.1128/jb.01299-07
Zinc-dependent cytoadherence of Legionella pneumophila to human alveolar epithelial cells in vitro 10.1016/j.micpath.2007.06.002
Chemical force microscopy of single live cells 10.1021/nl071476k
Mycobacterium smegmatis produces an HBHA homologue which is not involved in epithelial adherence 10.1016/j.micinf.2006.11.007
Ethambutol-induced alterations in Mycobacterium bovis BCG imaged by atomic force microscopy 10.1111/j.1574-6968.2006.00443.x
Live attenuated B. pertussis as a single-dose nasal vaccine against whooping cough 10.1371/journal.ppat.0020065
Genetic exchange of the S2 and S3 subunits in pertussis toxin 10.1111/j.1365-2958.2006.05165.x
Attenuated Bordetella pertussis: new live vaccines for intranasal immunisation. 10.1016/j.vaccine.2005.01.120
Nanoscale mapping and functional analysis of individual adhesins on living bacteria 10.1038/nmeth769
Mycobacterium tuberculosis heparin-binding haemagglutinin adhesin (HBHA) triggers receptor-mediated transcytosis without altering the integrity of tight junctions 10.1016/j.micinf.2005.03.023
Role of Bordetella bronchiseptica adenylate cyclase in nasal colonization and in development of local and systemic immune responses in piglets 10.1051/vetres:2004056
Bordetella pertussis from functional genomics to intranasal vaccination 10.1078/1438-4221-00288
Role of ADP-ribosyltransferase activity of pertussis toxin in toxin-adhesin redundancy with filamentous hemagglutinin during Bordetella pertussis infection. 10.1128/iai.69.10.6038-6043.2001
New virulence-activated and virulence-repressed genes identified by systematic gene inactivation and generation of transcriptional fusions in Bordetella pertussis. 10.1128/jb.182.20.5902-5905.2000
Structure of the low-affinity penicillin-binding protein 5 PBP5fm in wild-type and highly penicillin-resistant strains of Enterococcus faecium. 10.1128/jb.178.16.4948-4957.1996
Cloning and sequencing of the low-affinity penicillin-binding protein 3r-encoding gene of Enterococcus hirae S185: modular design and structural organization of the protein. 10.1128/jb.175.10.2844-2852.1993
The periplasmic binding protein of a tripartite tricarboxylate transporter is involved in signal transduction 10.1016/j.jmb.2005.05.071
Diversion of complement-mediated killing by Bordetella 10.1016/j.micinf.2018.02.002
Construction and evaluation of Bordetella pertussis live attenuated vaccine strain BPZE1 producing Fim3 10.1016/j.vaccine.2018.02.017
Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin 10.1099/00221287-148-4-1193
Rv0613c/MSMEG_1285 Interacts with HBHA and Mediates Its Proper Cell-Surface Exposure in Mycobacteria 10.3390/ijms19061673
Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria. 10.3389/fmicb.2018.02258
Coordinate regulation of virulence and metabolic genes by the transcription factor HbhR in Mycobacterium marinum 10.1111/mmi.14400
Quantity and quality of antibodies after acellular versus whole cell pertussis vaccines in infants born to mothers who received Tdap during pregnancy: a randomised trial. 10.1093/cid/ciz778
Development and Standardization of a High-Throughput Bordetella pertussis Growth-Inhibition Assay 10.3389/fmicb.2020.00777
Manufacture of a Stable Lyophilized Formulation of the Live Attenuated Pertussis Vaccine BPZE1 10.3390/vaccines8030523
Safety and immunogenicity of the live attenuated intranasal pertussis vaccine BPZE1: a phase 1b, double-blind, randomised, placebo-controlled dose-escalation study. 10.1016/s1473-3099(20)30274-7