Enhanced Acylcarnitine Annotation in High-Resolution Mass Spectrometry Data: Fragmentation Analysis for the Classification and Annotation of Acylcarnitines
Justin J.J. van der Hooft
L.O. Ridder
M.P. Barrett
K.E.V. Burgess
Karl Burgess
Burgess Karl
ORCID: 0000-0002-0881-715X
Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines.
10.3389/fbioe.2015.00026
Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism.
10.1016/j.ijpddr.2013.11.002
Strategies to dissect parasite proteomes.
10.1017/S0031182011002368
Recent advances in liquid and gas chromatography methodology for extending coverage of the metabolome
10.1016/j.copbio.2016.09.006
A novel targeted/untargeted GC-Orbitrap metabolomics methodology applied to Candida albicans and Staphylococcus aureus biofilms
10.1007/s11306-016-1134-2
MetaboCraft: building a Minecraft plugin for metabolomics
10.1093/bioinformatics/bty102
Minimally-destructive atmospheric ionisation mass spectrometry authenticates authorship of historical manuscripts
10.1038/s41598-018-28810-2
Plasma Itaconate elevation following successful cDMARD treatment in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation
10.1101/19001594
Changing environments and genetic variation: natural variation in inbreeding does not compromise short-term physiological responses
10.1098/rspb.2019.2109
Functional colour genes and signals of selection in colour‐polymorphic salamanders
10.1111/mec.15411
Decomposing metabolite set activity levels with PALS
10.1101/2020.06.07.138974
Schistosoma haematobium infection is associated with alterations in energy and purine-related metabolism in preschool-aged children
10.1371/journal.pntd.0008866
Ranking Metabolite Sets by Their Activity Levels
10.3390/metabo11020103
Justin van der Hooft
van der Hooft Justin
/ Justin J.J. van der Hooft
ORCID: 0000-0002-9340-5511
Structural elucidation of low abundant metabolites in complex sample matrices
10.1007/s11306-013-0519-8
Non-smoky GLYCOSYLTRANSFERASE1 prevents the release of smoky aroma from tomato fruit
10.1105/tpc.113.114231
Automatic chemical structure annotation of an LC-MSn based metabolic profile from green tea
10.1021/ac400861a
Substructure-based annotation of high-resolution multistage MSn spectral trees
10.1002/rcm.6364
Structural annotation and elucidation of conjugated phenolic compounds in black, green, and white tea extracts
10.1021/jf300297y
Structural elucidation and quantification of phenolic conjugates present in human urine after tea intake
10.1021/ac3017339
Spectral trees as a robust annotation tool in LC-MS based metabolomics
10.1007/s11306-011-0363-7
Metabolite identification using automated comparison of high-resolution multistage mass spectral trees
10.1021/ac2034216
Inhibitory activity of plumbagin produced by Drosera intermedia on food spoilage fungi
10.1002/jsfa.5522
A strategy for fast structural elucidation of metabolites in small volume plant extracts using automated MS-guided LC-MS-SPE-NMR
10.1002/mrc.2833
Thermal diffusivity of periderm from tomatoes of different maturity stages as determined by the concept of the frequency-domain open photoacoustic cell
10.1063/1.3530735
Polyphenol identification based on systematic and robust high-resolution accurate mass spectrometry fragmentation
10.1021/ac102546x
Iridoid and caffeoyl phenylethanoid glycosides of the endangered carnivorous plant Pinguicula lusitanica L. (Lentibulariaceae)
10.1016/j.bse.2009.05.003
Topic modeling for untargeted substructure exploration in metabolomics
10.1073/pnas.1608041113
Propagating annotations of molecular networks using in silico fragmentation
10.1371/journal.pcbi.1006089
Did a plant-herbivore arms race drive chemical diversity in Euphorbia?
10.1101/323014
Automatic Compound Annotation from Mass Spectrometry Data Using MAGMa.
10.5702/massspectrometry.S0033
Interactions of blacktea polyphenols with human gut microbiota: implications for gut and cardiovascular health
10.3945/ajcn.113.058263
Identification of a drimenol synthase and drimenol oxidase from Persicaria hydropiper, involved in the biosynthesis of insect deterrent drimanes
10.1111/tpj.13527
Enhanced Acylcarnitine Annotation in High-Resolution Mass Spectrometry Data: Fragmentation Analysis for the Classification and Annotation of Acylcarnitines
10.3389/fbioe.2015.00026
Rapid and sustained systemic circulation of conjugated gut microbiol catabolites after single-dose black tea extract consumption
10.1021/pr5001253
In Silico Prediction and Automatic LC–MSn Annotation of Green Tea Metabolites in Urine
10.1021/ac403875b
Unexpected differential metabolic responses of Campylobacter jejuni to the abundant presence of glutamate and fucose
10.1007/s11306-018-1438-5
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae
10.1101/463620
Deciphering complex metabolite mixtures by unsupervised and supervised substructure discovery and semi-automated annotation from MS/MS spectra
10.1101/491506
Accelerating metabolite identification in natural product research: toward an ideal combination of LC-HRMS/MS and NMR profiling, in silico databases and chemometrics
10.1021/acs.analchem.8b05112
Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages
10.1101/347716
Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings
https://doi.org/10.1016/j.mam.2017.11.002
Metabolite Identification in Complex Mixtures Using Nuclear Magnetic Resonance Spectroscopy
10.1007/978-3-319-28275-6_6-2
Ms2lda.org: web-based topic modelling for substructure discovery in mass spectrometry
10.1093/bioinformatics/btx582
A comprehensive evaluation of the [2-14C](–)-epicatechin metabolome in rats
https://doi.org/10.1016/j.freeradbiomed.2016.08.001
The food metabolome: a window over dietary exposure
10.3945/ajcn.113.076133
Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols
10.3945/ajcn.113.058958
Unsupervised Discovery and Comparison of Structural Families Across Multiple Samples in Untargeted Metabolomics
10.1021/acs.analchem.7b01391
A community-driven paired data platform to accelerate natural product mining by combining structural information from genomes and metabolomes
10.18174/FAIRdata2018.16286
Implementations of the chemical structural and compositional similarity metric in R and Python
10.1101/546150
Comprehensive mass spectrometry-guided phenotyping of plant specialized metabolites reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae
10.1111/tpj.14292
A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters
10.1186/s13104-019-4222-3
The Metabolomics Society—Current State of the Membership and Future Directions
10.3390/metabo9050089
Deciphering complex metabolite mixtures by unsupervised and supervised substructure discovery and semi-automated annotation from MS/MS spectra
10.1039/C8FD00235E
MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools
10.1101/654459
Substantial extracellular metabolic differences found between phylogenetically closely related probiotic and pathogenic strains of Escherichia coli
10.3389/fmicb.2019.00252
Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia l.
10.3389/fpls.2019.00846
Molnetenhancer: Enhanced molecular networks by integrating metabolome mining and annotation tools
10.3390/metabo9070144
In Silico Optimization of Mass Spectrometry Fragmentation Strategies in Metabolomics
10.3390/metabo9100219
MIBiG 2.0: a repository for biosynthetic gene clusters of known function
10.1093/nar/gkz882
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages
10.1016/j.foodchem.2019.125290
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery
10.1021/acscentsci.9b00806
Mass spectrometry searches using MASST
10.1038/s41587-019-0375-9
Assessing specialized metabolite diversity of Alnus species by a digitized LC–MS/MS data analysis workflow
10.1016/j.phytochem.2020.112292
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication
10.1126/sciadv.aax6328
Chemically-informed Analyses of Metabolomics Mass Spectrometry Data with Qemistree
10.1101/2020.05.04.077636
Linking genomics and metabolomics to chart specialized metabolic diversity
10.1039/D0CS00162G
Reproducible molecular networking of untargeted mass spectrometry data using GNPS
10.1038/s41596-020-0317-5
Decomposing metabolite set activity levels with PALS
10.1101/2020.06.07.138974
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions
10.1101/2020.06.12.148205
Phenylpropane as an Alternative Dearomatizing Unit of Indoles: Discovery of Inaequalisines A and B Using Substructure-Informed Molecular Networking
10.1021/acs.orglett.0c02153
matchms - processing and similarity evaluation of mass spectrometry data
10.1101/2020.08.06.239244
Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships
10.1101/2020.08.11.245928
BiG-SLiCE: A Highly Scalable Tool Maps the Diversity of 1.2 Million Biosynthetic Gene Clusters
10.1101/2020.08.17.240838
matchms - processing and similarity evaluation of mass spectrometry data.
10.21105/joss.02411
ReDU: a framework to find and reanalyze public mass spectrometry data
10.1038/s41592-020-0916-7
Feature-based molecular networking in the GNPS analysis environment
10.1038/s41592-020-0933-6
Rapid Development of Improved Data-dependent Acquisition Strategies
10.1101/2020.09.11.293092
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree
10.1038/s41589-020-00677-3
Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data
10.1038/s41587-020-0700-3
The ant fungus garden acts as an external digestive system
10.1101/2020.11.18.389361
BiG-MAP: an automated pipeline to profile metabolic gene cluster abundance and expression in microbiomes
10.1101/2020.12.14.422671
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters
10.1093/gigascience/giaa154
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
10.1371/journal.ppat.1008932
Comparative Metabologenomics Analysis of Polar Actinomycetes
10.3390/md19020103
Ranking Metabolite Sets by Their Activity Levels
10.3390/metabo11020103
Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships
10.1371/journal.pcbi.1008724
Rapid Development of Improved Data-Dependent Acquisition Strategies
10.1021/acs.analchem.0c03895
MS2DeepScore - a novel deep learning similarity measure for mass fragmentation spectrum comparisons
10.1101/2021.04.18.440324
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions
10.1371/journal.pcbi.1008920
Metabolomics-Guided Elucidation of Plant Abiotic Stress Responses in the 4IR Era: An Overview
10.3390/metabo11070445
Chemical Gradients of Plant Substrates in an Atta texana Fungus Garden
10.1128/mSystems.00601-21
Comprehensive Large-Scale Integrative Analysis of Omics Data To Accelerate Specialized Metabolite Discovery
10.1128/mSystems.00726-21
Mike Barrett
Barrett Mike
ORCID: 0000-0001-9447-3519
Why aren't we doing more to safeguard vulnerable adults from thermal injuries?
10.1016/j.neurobiola.08.018
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.
10.1073/pnas.1505411112
Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites.
10.1371/journal.ppat.1004882
An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei.
10.1371/journal.ppat.1004875
Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.
10.1371/journal.pntd.0003714
Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose.
10.1371/journal.ppat.1004689
Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines.
10.3389/fbioe.2015.00026
Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool.
10.1128/AAC.05046-14
Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.
10.1021/bi501366a
Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione.
10.1124/mol.114.096016
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
10.1093/nar/gku944
Metabolomic-based strategies for anti-parasite drug discovery.
10.1177/1087057114551519
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.
10.1021/jm500483b
BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei.
10.1371/journal.ppat.1004263
Trypanosoma brucei: meet the system.
10.1016/j.mib.2014.06.007
Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis.
10.1128/AAC.01449-13
Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.
10.1371/journal.pntd.0002844
Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics.
10.1002/anie.201310401
Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks.
10.4155/bio.13.348
Emerging paradigms in anti-infective drug design.
10.1017/S0031182013001224
The silicon trypanosome: a test case of iterative model extension in systems biology.
10.1016/B978-0-12-800143-1.00003-8
Shape-dependent optoelectronic cell lysis.
10.1002/anie.201307751
Green fluorescent diamidines as diagnostic probes for trypanosomes.
10.1128/AAC.02024-13
Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei.
10.1371/journal.pcbi.1003371
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
10.1093/jac/dkt442
A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity.
10.1371/journal.ppat.1003731
The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control.
10.1111/mmi.12351
In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis.
10.1371/journal.pntd.0002384
Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis.
10.1111/febs.12436
Determination of antiprotozoal drug mechanisms by metabolomics approaches.
10.1017/S0031182013000814
Metabolite-dependent regulation of gene expression in Trypanosoma brucei.
10.1111/mmi.12243
Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei.
10.1128/AAC.00044-13
Minor groove binders as anti-infective agents.
10.1016/j.pharmthera.2013.03.002
Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake.
10.1016/j.ijpddr.2013.01.004
The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii.
10.1111/mmi.12139
mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data.
10.1093/bioinformatics/bts674
Management of trypanosomiasis and leishmaniasis.
10.1093/bmb/lds031
Counterflow dielectrophoresis for trypanosome enrichment and detection in blood.
10.1038/srep00775
Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation.
10.1021/ac3018795
Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT.
10.1016/j.bmc.2012.08.049
Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.
10.1002/cmdc.201200304
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
10.1073/pnas.1202885109
Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.
10.1371/journal.pntd.0001618
IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data.
10.1093/bioinformatics/bts069
Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine.
10.1021/ac2030738
Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism.
10.1371/journal.pcbi.1002352
A comparison of leg length and femoral offset discrepancies in hip resurfacing, large head metal-on- metal and conventional total hip replacement: a case series.
10.1186/1749-799X-6-65
Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry.
10.1002/rcm.5247
Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry.
10.1002/rcm.5245
Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction.
10.1021/ac2021823
Metabolomic analysis of trypanosomatid protozoa.
10.1016/j.molbiopara.2011.10.003
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.
10.1371/journal.pntd.0001308
Drug resistance in human African trypanosomiasis.
10.2217/fmb.11.88
Development of novel drugs for human African trypanosomiasis.
10.2217/fmb.11.44
Transketolase in Trypanosoma brucei.
10.1016/j.molbiopara.2011.04.006
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.
10.1124/mol.111.071555
Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry.
10.1002/rcm.4939
Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.
10.1128/AAC.01551-10
A glucose transporter can mediate ribose uptake.: DEFINITION OF RESIDUES THAT CONFER SUBSTRATE SPECIFICITY IN A SUGAR TRANSPORTER.
10.1074/jbc.A110.106815
Separation of parasites from human blood using deterministic lateral displacement.
10.1039/c0lc00560f
Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity.
10.1016/j.bmc.2011.01.010
Synthesis and in vitro/in vivo evaluation of the antitrypanosomal activity of 3-bromoacivicin, a potent CTP synthetase inhibitor.
10.1002/cmdc.201000417
The 6-phosphogluconate dehydrogenase of Leishmania (Leishmania) mexicana: gene characterization and protein structure prediction.
10.1159/000320697
Potential new drugs for human African trypanosomiasis: some progress at last.
10.1097/QCO.0b013e32833f9fd0
A molecular mechanism for eflornithine resistance in African trypanosomes.
10.1371/journal.ppat.1001204
Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds.
10.1021/jm1004754
A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes.
10.1016/j.molbiopara.2010.07.002
A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter.
10.1074/jbc.M110.106815
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.
10.1016/j.bmcl.2010.06.070
Multiple roles of proline transport and metabolism in trypanosomatids.
10.2741/3931
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.
10.1016/j.bmc.2010.05.077
The silicon trypanosome.
10.1017/S0031182010000466
MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks.
10.1093/nar/gkq312
Metabolomic systems biology of trypanosomes.
10.1017/S003118201000017X
Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining.
10.1007/s11306-009-0196-9
Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.
10.1128/EC.00200-09
Predictive computational models of substrate binding by a nucleoside transporter.
10.1074/jbc.M109.049726
Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal.
10.1371/journal.pntd.0000523
The Toxoplasma gondii plastid replication and repair enzyme complex, PREX.
10.1017/S0031182009006027
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
10.1093/brain/awp074
Unsaturated Mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains.
10.1002/cmdc.200800360
Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.
10.1016/j.bmc.2009.01.058
Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites.
10.1039/b813394h
Paromomycin: uptake and resistance in Leishmania donovani.
10.1016/j.molbiopara.2008.12.007
The natural progression of Gambiense sleeping sickness: what is the evidence?
10.1371/journal.pntd.0000303
Increasing the mass accuracy of high-resolution LC-MS data using background ions: a case study on the LTQ-Orbitrap.
10.1002/pmic.200800314
Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis.
10.1016/j.bmcl.2008.09.047
Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.
10.1128/AAC.01450-07
Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules.
10.1002/rcm.3564
Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei.
10.1074/jbc.M709592200
N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift.
10.1017/S0031182008004241
African sleeping sickness.
10.1136/bmj.39505.490544.BE
Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.
10.1016/j.bmcl.2008.02.037
New surveyor tools for charting microbial metabolic maps.
10.1038/nrmicro1797
MetaNetter: inference and visualization of high-resolution metabolomic networks.
10.1093/bioinformatics/btm536
A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase.
10.1016/j.jprot.2007.11.002
Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles.
10.1039/b710487a
McArthur revisited: fluorescence microscopes for field diagnostics.
10.1016/j.pt.2007.08.003
Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.
10.1002/cmdc.200700040
Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.
10.1038/sj.bjp.0707354
Molecular cloning, expression and characterization of ribokinase of Leishmania major.
10.1111/j.1745-7270.2007.00298.x
Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates.
10.1111/j.1742-4658.2006.05585.x
Precision mapping of the metabolome.
10.1016/j.tibtech.2006.10.006
Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance.
10.1124/mol.106.024653
DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.
10.1021/jm060295c
The rise and fall of sleeping sickness.
10.1016/S0140-6736(06)68591-7
Targeting of toxic compounds to the trypanosome's interior.
10.1016/S0065-308X(06)63002-9
Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter.
10.1128/AAC.49.12.5169-5171.2005
Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani.
10.1016/j.molbiopara.2005.08.016
Chemotherapy of trypanosomiases and leishmaniasis.
10.1016/j.pt.2005.08.026
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
10.1021/jm050177+
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test.
10.1016/S0140-6736(05)66793-1
The plastidic DNA replication enzyme complex of Plasmodium falciparum.
10.1016/j.molbiopara.2005.02.002
Energy generation in insect stages of Trypanosoma brucei: metabolism in flux.
10.1016/j.pt.2005.02.008
Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose.
10.1074/jbc.M414274200
Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites.
10.1093/nar/gkh907
6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes.
10.2174/0929867043364441
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
10.1021/jm031066i
Trypanocidal activity of melamine-based nitroheterocycles.
10.1128/AAC.48.5.1733-1738.2004
The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.
10.1128/AAC.48.5.1515-1519.2004
Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter.
10.1016/j.bcp.2003.09.005
The trypanosomiases.
10.1016/S0140-6736(03)14694-6
Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.
10.1128/AAC.47.10.3368-3370.2003
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
10.1128/EC.2.5.1003-1008.2003
Pentose phosphate metabolism in Leishmania mexicana.
10.1016/S0166-6851(03)00173-7
Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis.
10.1016/S0968-0896(03)00191-3
Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines.
10.1093/jac/dkg307
Waking up to sleeping sickness.
10.1016/S1471-4922(03)00055-2
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.
10.1016/S1471-4922(03)00069-2
Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan.
10.1074/jbc.M301252200
Genetic characterization of glucose transporter function in Leishmania mexicana.
10.1073/pnas.0630165100
Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.
10.1128/AAC.46.12.3731-3738.2002
Polymorphism among alleles of the 6-phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica.
10.1016/S0166-6851(02)00213-X
Perspectives for new drugs against trypanosomiasis and leishmaniasis.
10.2174/1568026024607427
Sleeping sickness and the brain.
10.1007/s00018-002-8472-0
A large gene family for putative variant antigens shared by human and rodent malaria parasites.
10.1098/rspb.2001.1903
Chemotherapy of human African trypanosomiasis.
10.2174/1381612023396159
Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.
10.1021/jm010854+
Life in vacuoles--nutrient acquisition by Leishmania amastigotes.
10.1016/S0020-7519(01)00259-4
Veterinary link to drug resistance in human African trypanosomiasis?
10.1016/S0140-6736(01)05817-2
Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei.
10.1023/A:1011196508214
Gene discovery in Plasmodium chabaudi by genome survey sequencing.
10.1016/S0166-6851(01)00224-9
Uptake and mode of action of drugs used against sleeping sickness.
10.1016/S0006-2952(00)00477-9
Transport of methionine in Trypanosoma brucei brucei.
10.1016/S0166-6851(00)00321-2
Drug uptake via nutrient transporters in Trypanosoma brucei.
10.1046/j.1365-2672.2000.01168.x
The structure-function relationship of functionally distinct but structurally similar hexose transporters from Trypanosoma congolense.
10.1046/j.1432-1327.2000.01543.x
Putrescine and spermidine transport in Leishmania.
10.1016/S0166-6851(00)00234-6
Uptake of the nitroimidazole drug megazol by African trypanosomes.
10.1016/S0006-2952(99)00368-8
Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes.
10.1016/S0166-6851(99)00206-6
Anti-sleeping sickness drugs and cancer chemotherapy.
10.1016/S0169-4758(99)01560-4
A drug resistance determinant in Trypanosoma brucei.
10.1016/S0966-842X(99)01643-1
Structure and function of facilitative sugar transporters.
10.1016/S0955-0674(99)80072-6
The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes.
10.1016/S0169-4758(99)01414-3
The fall and rise of sleeping sickness.
10.1016/S0140-6736(98)00416-4
Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.
10.1016/S0966-842X(98)01433-4
Trypanosomiasis and leishmaniasis: between the idea and the reality of control.
10.1016/S0169-4758(98)01374-X
6-Phosphogluconate dehydrogenase from Lactococcus lactis: a role for arginine residues in binding substrate and coenzyme.
10.1042/0264-6021:3380055
Affinity chromatography using trypanocidal arsenical drugs identifies a specific interaction between glycerol-3-phosphate dehydrogenase from Trypanosoma brucei and Cymelarsan.
10.1046/j.1432-1327.1999.00048.x
6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species.
10.1016/S0167-4838(98)00222-2
Sugar transporters from bacteria, parasites and mammals: structure-activity relationships.
10.1016/S0968-0004(98)01326-7
Crystallization and preliminary X-ray diffraction studies of 6-phosphogluconate dehydrogenase from Lactococcus lactis.
10.1107/S0907444998004909
A 2.8 A resolution structure of 6-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei: comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues.
10.1006/jmbi.1998.2059
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
10.1074/jbc.273.31.19383
An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.
10.1016/S0960-894X(98)00095-X
Trypanosome glucose transporters.
10.1016/S0166-6851(97)00192-8
A single locus minisatellite sequence which distinguishes between Trypanosoma brucei isolates.
10.1016/S0166-6851(97)02832-6
The pentose phosphate pathway and parasitic protozoa.
10.1016/S0169-4758(96)10075-2
6-Phosphogluconate dehydrogenase from Trypanosoma brucei. Kinetic analysis and inhibition by trypanocidal drugs.
10.1111/j.1432-1033.1996.0592h.x
A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity.
10.1016/0166-6851(95)00120-P
Characterization of glucose transport and cloning of a hexose transporter gene in Trypanosoma cruzi.
10.1073/pnas.91.17.8278
Overexpression in Escherichia coli and purification of the 6-phosphogluconate dehydrogenase of Trypanosoma brucei.
10.1006/prep.1994.1006
Preliminary crystallographic study of 6-phosphogluconate dehydrogenase from Trypanosoma brucei.
10.1006/jmbi.1993.1510
A 6-phosphogluconate dehydrogenase gene from Trypanosoma brucei.
10.1016/0166-6851(93)90247-U
Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana
10.1371/journal.ppat.1006953
The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis
10.1371/journal.pntd.0006925
Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
10.1371/journal.ppat.1007475
Plasma Itaconate elevation following successful cDMARD treatment in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation
10.1101/19001594
Protozoan persister-like cells and drug treatment failure
10.1038/s41579-019-0238-x
Pharma to farmer: field challenges of optimizing trypanocide use in African animal trypanosomiasis
10.1016/j.pt.2021.04.007