ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton
Ok‐Ryul Song Christophe J Queval Raffaella Iantomasi Vincent Delorme Sabrina Marion Romain Veyron‐Churlet Elisabeth Werkmeister Michka Popoff Isabelle Ricard Samuel Jouny Nathalie Deboosere Frank Lafont Alain Baulard Edouard Yeramian Laurent Marsollier Eik Hoffmann Priscille Brodin
EMBO reports, 2017-11-15
https://doi.org/10.15252/embr.201744371
Vincent Delorme
Delorme Vincent
ORCID: 0000-0001-5235-7069
Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent. 10.1016/j.bmc.2020.115797
Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. 10.1016/j.stemcr.2019.10.002
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis. 10.1016/j.bioorg.2018.08.025
Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains. 10.3389/fcimb.2018.00114
Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-018-25177-2
Mycobacterium tuberculosis Infection and Innate Responses in a New Model of Lung Alveolar Macrophages. 10.3389/fimmu.2018.00438
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. 10.1038/s41598-017-11843-4
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 10.1016/j.celrep.2017.08.101
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-017-05453-3
Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis. 10.1128/aac.02637-16
Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. 10.1021/acschembio.7b00091
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. 10.1126/science.aag1006
High-Content Screening of Raw Actinomycete Extracts for the Identification of Antituberculosis Activities. 10.1177/1087057116675887
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. 10.1039/c5ob02630j
Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays. 10.1007/978-1-4939-2450-9_24
2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1. 10.1021/cb5007163
Supported inhibitor for fishing lipases in complex biological media and mass spectrometry identification. 10.1016/j.biochi.2014.07.015
A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114
Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones. 10.1016/j.ejmech.2012.10.040
MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth. 10.1371/journal.pone.0046493
Inhibition of phospholipase A1, lipase and galactolipase activities of pancreatic lipase-related protein 2 by methyl arachidonyl fluorophosphonate (MAFP). 10.1016/j.bbalip.2012.07.014
Effects of surfactants on lipase structure, activity, and inhibition. 10.1007/s11095-010-0362-9
CO2 binding by dynamic combinatorial chemistry: an environmental selection. 10.1021/ja909975q
Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function. 10.1096/fj.09-144766
Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases. 10.1021/jm301216x
Phenotypic Screening for Drug Discovery in Tuberculosis https://doi.org/10.1039/9781839160721-00198
Eik Hoffmann
Hoffmann Eik
ORCID: 0000-0003-4224-1091
Host-directed therapies offer novel opportunities for the fight against tuberculosis. 10.1016/j.drudis.2017.05.005
Evaluation of Cross-presentation in Bone Marrow-derived Dendritic Cells in vitro and Splenic Dendritic Cells ex vivo Using Antigen-coated Beads. 10.21769/BioProtoc.2015
Patterns, Receptors, and Signals: Regulation of Phagosome Maturation. 10.1016/j.it.2017.03.006
Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages. 10.1016/j.immuni.2016.02.017
Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens. 10.1016/j.immuni.2015.11.006
Autonomous phagosomal degradation and antigen presentation in dendritic cells. 10.1073/pnas.1203912109
Reactive oxygen species production in the phagosome: impact on antigen presentation in dendritic cells. 10.1089/ars.2012.4557
Comparison of micro- and nanoscale Fe⁺³-containing (Hematite) particles for their toxicological properties in human lung cells in vitro. 10.1093/toxsci/kfs014
Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells. 10.1186/1743-8977-6-17
The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells. 10.1038/ni.2808
Synthesis of the compatible solutes glucosylglycerol and trehalose by salt-stressed cells of Stenotrophomonas strains. 10.1016/j.femsle.2004.12.005
Ezrin promotes actin assembly at the phagosome membrane and regulates phago-lysosomal fusion. 10.1111/j.1600-0854.2011.01158.x
Initial receptor-ligand interactions modulate gene expression and phagosomal properties during both early and late stages of phagocytosis. 10.1016/j.ejcb.2010.04.006
Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation. 10.1242/jcs.034207
Dynamin A, Myosin IB and Abp1 couple phagosome maturation to F-actin binding. 10.1111/j.1600-0854.2011.01296.x
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371
Host-pathogen systems for early drug discovery against tuberculosis. 10.1016/j.mib.2017.11.017
Proteomics of Mycobacterium Infection: Moving towards a Better Understanding of Pathogen-Driven Immunomodulation 10.3389/fimmu.2018.00086
The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902
Spatiotemporal changes of the phagosomal proteome in dendritic cells in response to LPS stimulation 10.1074/mcp.RA119.001316
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551
Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies 10.3389/fimmu.2020.569127
High-Content Analysis Monitoring Intracellular Trafficking and Replication of Mycobacterium tuberculosis Inside Host Cells 10.1007/978-1-0716-1460-0_29
The UPR sensor IRE1α promotes dendritic cell responses to control Toxoplasma gondii infection 10.15252/embr.201949617
Alain Baulard
Baulard Alain / Alain Robert Baulard
ORCID: 0000-0002-0150-5241
Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2 10.1016/j.bbrc.2017.04.074
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371
Mercury resistance as a selective marker for recombinant mycobacteria 10.1099/13500872-141-4-1045
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Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3 10.1038/s41598-017-05453-3.
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030 10.1016/j.ijpharm.2017.05.030. Epub 2017 May 15.
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091 10.1021/acschembio.7b00091. Epub 2017 Apr 5.
New active leads for tuberculosis booster drugs by structure-based drug discovery 10.1039/c7ob00910k 10.1039/c7ob00910k.
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129 10.1002/cyto.a.23129.
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006 10.1126/science.aag1006. Epub 2017 Mar 16.
Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2 10.1016/j.bbrc.2017.04.074 10.1016/j.bbrc.2017.04.074. Epub 2017 Apr 14.
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j 10.1039/c5ob02630j. Epub 2016 Jan 25.
Effects of Lipid-Lowering Drugs on Vancomycin Susceptibility of Mycobacteria 10.1128/AAC.00872-16 10.1128/AAC.00872-16. Print 2016 Oct.
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297 10.1038/srep29297.
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG 10.1016/j.chembiol.2015.05.016 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18.
Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches 10.1021/jm500422b 10.1021/jm500422b. Epub 2014 May 28.
The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation 10.1016/j.bbrc.2014.03.074 10.1016/j.bbrc.2014.03.074. Epub 2014 Mar 22.
Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands 10.1016/j.ab.2014.02.011 10.1016/j.ab.2014.02.011. Epub 2014 Feb 20.
Mechanism of competence activation by the ComRS signalling system in streptococci 10.1111/mmi.12157 10.1111/mmi.12157. Epub 2013 Feb 4.
Structural and docking studies of potent ethionamide boosters 10.1107/S0108270113028126 10.1107/S0108270113028126. Epub 2013 Oct 24.
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis 10.1021/jm300377g 10.1021/jm300377g. Epub 2012 Jul 17.
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors 10.1021/jm200825u 10.1021/jm200825u. Epub 2011 Dec 6.
Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands 10.1093/nar/gkr1113 10.1093/nar/gkr1113. Epub 2011 Dec 9.
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Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors 10.1021/jm200076a 10.1021/jm200076a. Epub 2011 Apr 1.
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Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis 10.1128/AAC.01197-08 10.1128/AAC.01197-08. Epub 2009 Feb 23.
Molecular mapping of lipoarabinomannans on mycobacteria 10.1021/la900302a 10.1021/la900302a.
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Organization of the mycobacterial cell wall: a nanoscale view 10.1007/s00424-007-0386-0
Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis 10.1080/00365540701402954
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Direct measurement of hydrophobic forces on cell surfaces using AFM 10.1021/la702765c
Effects of mechanical wounding on Carica papaya cysteine endopeptidases accumulation and activity 10.1016/j.ijbiomac.2006.02.021
Ethambutol-induced alterations in Mycobacterium bovis BCG imaged by atomic force microscopy 10.1111/j.1574-6968.2006.00443.x
Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis 10.1016/j.tube.2005.07.005
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Monitoring of the ethionamide pro-drug activation in mycobacteria by (1)H high resolution magic angle spinning NMR 10.1016/j.bbrc.2005.03.197
[Doping in the peloton of antituberculosis drugs] 10.1051/medsci/2005214351
Cloning, expression, and purification of the 27 kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis 10.1016/j.pep.2004.01.016
Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis 10.1194/jlr.M400047-JLR200
Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis 10.1016/j.molcel.2004.09.020
In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system 10.1074/jbc.M207922200
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Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis 10.1074/jbc.M311209200
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis 10.1042/BJ20020107
Activation of the pro-drug ethionamide is regulated in mycobacteria 10.1074/jbc.M003744200
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis 10.1074/jbc.M000569200
A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J
Priscille Brodin
Brodin Priscille
ORCID: 0000-0003-0991-7344
Email: priscille.brodin@inserm.fr
How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011
Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227
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Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections 10.2217/nnm-2016-0364
Cyclodextrin-based nanocarriers containing a synergic drug combination: a potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030 10.1016/j.ijpharm.2017.05.030.
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z
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Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535
Impact of pe_ pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis 10.3389/fcimb.2017.00137
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129 10.1002/cyto.a.23129.
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5
Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization 10.1016/j.str.2016.07.009
Mycolactone The amazing analgesic mycobacterial toxin 10.1051/medsci/20163202007
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650
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Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays 10.1007/978-1-4939-2450-9_24
A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening 10.3791/51114
Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/jm500422b
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Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779
Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u
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Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200076a
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ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371 10.15252/embr.201744371.
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017 10.1016/j.mib.2017.11.017.
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101 10.1016/j.celrep.2017.08.101.
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114 10.1073/pnas.1707840114.
Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry 10.1128/jvi.01982-17
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025
Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation 10.3389/fimmu.2018.00086
Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis 10.1128/aac.00359-18
The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020
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deboosere Nathalie
ORCID: 0000-0002-2873-5485
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Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
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Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483
Sabrina Marion
Marion Sabrina
ORCID: 0000-0001-7824-955X
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371
Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division. 10.1371/journal.ppat.1006331
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Initial receptor-ligand interactions modulate gene expression and phagosomal properties during both early and late stages of phagocytosis. 10.1016/j.ejcb.2010.04.006
Bioinformatics and functional analysis of an Entamoeba histolytica mannosyltransferase necessary for parasite complement resistance and hepatical infection. 10.1371/journal.pntd.0000165
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Signaling through the phosphatidylinositol 3-kinase regulates mechanotaxis induced by local low magnetic forces in Entamoeba histolytica. 10.1016/j.jbiomech.2005.11.012
Genomic and proteomic approaches highlight phagocytosis of living and apoptotic human cells by the parasite Entamoeba histolytica. 10.1016/j.ijpara.2005.10.007
Signalization and cytoskeleton activity through myosin IB during the early steps of phagocytosis in Entamoeba histolytica: a proteomic approach. 10.1111/j.1462-5822.2005.00573.x
Acto-myosin cytoskeleton dependent viscosity and shear-thinning behavior of the amoeba cytoplasm. 10.1007/s00249-004-0449-5
Overexpression of myosin IB in living Entamoeba histolytica enhances cytoplasm viscosity and reduces phagocytosis. 10.1242/jcs.01178
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Phospholipid Scramblase 1 Modulates FcR-Mediated Phagocytosis in Differentiated Macrophages 10.1371/journal.pone.0145617
The NF-κB Signaling Protein Bcl10 Regulates Actin Dynamics by Controlling AP1 and OCRL-Bearing Vesicles 10.1016/j.devcel.2012.09.021
Actin-binding protein regulation by microRNAs as a novel microbial strategy to modulate phagocytosis by host cells: the case of N-Wasp and miR-142-3p 10.3389/fcimb.2013.00019
Secretory organelle trafficking in Toxoplasma gondii: A long story for a short travel 10.1016/j.ijmm.2018.07.007
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Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes 10.1038/s41598-019-44542-3
Toxoplasma and Dendritic Cells: An Intimate Relationship That Deserves Further Scrutiny 10.1016/j.pt.2019.08.001
Rab11A regulates the constitutive secretory pathway during Toxoplasma gondii invasion of host cells and parasite replication 10.1101/782391
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551
Association between schizophrenia and Toxoplasma gondii infection in Algeria. 10.1016/j.psychres.2020.113293
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Ca2+-activated cleavage of ezrin visualised dynamically in living myeloid cells during cell surface area expansion 10.1242/jcs.236968
The UPR sensor IRE1α promotes dendritic cell responses to control Toxoplasma gondii infection 10.15252/embr.201949617
frank Lafont
Lafont frank
ORCID: 0000-0001-8668-2580
Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division 10.1101/2021.09.19.460967
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371
Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins. 10.1242/jcs.198176
Standardized Nanomechanical Atomic Force Microscopy Procedure (SNAP) for Measuring Soft and Biological Samples. 10.1038/s41598-017-05383-0
Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation. 10.1038/ncomms15839
Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4. 10.1038/ncomms15764
Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129
Alterations of the Coxiella burnetii Replicative Vacuole Membrane Integrity and Interplay with the Autophagy Pathway. 10.3389/fcimb.2017.00112
CLAFEM: Correlative light atomic force electron microscopy. 10.1016/bs.mcb.2017.03.010
Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division 10.1371/journal.ppat.1006331
[Autophagy, ATG proteins and infectious diseases]. 10.1051/medsci/20173303019
Characterization of a nuclear pore protein sheds light on the roles and composition of the Toxoplasma gondii nuclear pore complex. 10.1007/s00018-017-2459-3
Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models. 10.1038/srep40764
Adhesiveness of opportunistic Staphylococcus aureus to materials used in dental office: In vitro study. 10.1016/j.micpath.2016.12.014
Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and Yersinia. 10.1016/j.semcdb.2016.07.019
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease. 10.1016/j.ebiom.2016.06.002
Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection. 10.1038/ncomms11191
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High potential of adhesion to biotic and abiotic surfaces by opportunistic Staphylococcus aureus strains isolated from orthodontic appliances. 10.1016/j.micpath.2015.11.009
Assessment of adhesion, invasion and cytotoxicity potential of oral Staphylococcus aureus strains. 10.1016/j.micpath.2015.05.010
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Clag9 is not essential for PfEMP1 surface expression in non-cytoadherent Plasmodium falciparum parasites with a chromosome 9 deletion. 10.1371/journal.pone.0029039
cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization. 10.1016/j.chom.2011.09.014
Ubiquitylation and autophagy in the control of bacterial infections and related inflammatory responses. 10.1111/j.1462-5822.2011.01628.x
A role for septins in the interaction between the Listeria monocytogenes INVASION PROTEIN InlB and the Met receptor. 10.1016/j.bpj.2011.02.040
How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection. 10.1042/bc20100101
Autophagy employs a new DAGger against bacteria. 10.1016/j.chom.2010.07.009
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Galectin-3, a marker for vacuole lysis by invasive pathogens. 10.1111/j.1462-5822.2009.01415.x
How autophagy regulates the host cell signaling associated with the postpartum bacteria cocoon experienced as a danger signal. 10.4161/auto.5.8.10218
Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. 10.1016/j.chom.2009.07.005
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Force spectroscopy of the interaction between mycobacterial adhesins and heparan sulphate proteoglycan receptors. 10.1002/cphc.200900208
Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis. 10.1136/gut.2008.168443
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Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane. 10.1083/jcb.128.6.1043
Dissecting the molecular mechanisms of polarized membrane traffic: reconstitution of three transport steps in epithelial cells using streptolysin-O permeabilization. 10.1101/sqb.1995.060.01.081
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Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran