Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
Federica Giordani
Dominique Soldati-Favre
Daniel Paape
Isabel M. Vincent
Andrew W. Pountain
Fernando Fernández-Cortés
Eva Rico
Ning Zhang
Liam J. Morrison
Yvonne Freund
Michael J. Witty
Rosemary Peter
Darren Y. Edwards
Jonathan M. Wilkes
Justin J. J. van der Hooft
Clément Regnault
Kevin D. Read
David Horn
Mark C. Field
Michael P. Barrett
PLoS Pathogens, 2020-11-3
Daniel Paape
Paape Daniel
/ D Paape
ORCID: 0000-0003-4355-8058
Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani
10.1016/j.chembiol.2015.01.003
Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes
10.1371/journal.pntd.0003363
Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors
10.1021/jm5011397
The Leishmania majorBBSome subunit BBS1 is essential for parasite virulence in the mammalian host
10.1111/mmi.12383
Contribution of proteomics of Leishmania spp. to the understanding of differentiation, drug resistance mechanisms, vaccine and drug development
10.1016/j.jprot.2011.05.005
Gel free analysis of the proteome of intracellular Leishmania mexicana
10.1016/j.molbiopara.2009.10.009
Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing
10.4049/jimmunol.0803463
Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice
10.1096/fj.08-108712
Transgenic, fluorescent Leishmania mexicana allow direct analysis of the Proteome of intracellular amastigotes
10.1074/mcp.M700343-MCP200
Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe
10.1186/s13059-015-0788-9
Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation
10.1093/nar/gkw147
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase
10.1039/C5MD00241A
Changes to cholesterol trafficking in macrophages by Leishmania parasites infection
10.1002/mbo3.469
Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei
10.1021/acsinfecdis.6b00034
Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation
10.7554/elife.12765
Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model
10.1186/s13071-020-3999-1
Leishmania Encodes a Bacterium-like 2,4-Dienoyl-Coenzyme A Reductase That Is Required for Fatty Acid β-Oxidation and Intracellular Parasite Survival
10.1128/mbio.01057-20
Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes
10.1021/acs.jmedchem.0c00570
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
10.1038/s41564-020-0745-6
Erratum to Gel free analysis of the proteome of intracellular Leishmania mexicana, [Mol. Biochem. Parasitol. (2010), 169, 108-114]
10.1016/j.molbiopara.2010.06.009
Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.
10.1371/journal.pntd.0008447
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei.
10.7554/elife.56416
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
10.1371/journal.ppat.1008932
Liam Morrison
Morrison Liam
ORCID: 0000-0002-8304-9066
Animal African Trypanosomiasis: Time to Increase Focus on Clinically Relevant Parasite and Host Species
10.1016/j.pt.2016.04.012
The animal trypanosomiases and their chemotherapy: a review
10.1017/s0031182016001268
Trypanosome genetics: Populations, phenotypes and diversity
10.1016/j.vetpar.2011.04.024
African Trypanosomes Increase Calcium Wave Frequency in Isolated Adult Rat Cardiomyocytes via Secretion of Cathepsin L
10.1016/j.bpj.2010.12.3258
Transmission Dynamics of Rhodesian Sleeping Sickness at the Interface of Wildlife and Livestock Areas
10.1016/j.pt.2016.05.003
Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity
10.1111/j.1462-5822.2009.01383.x
Probabilistic order in antigenic variation of Trypanosoma brucei
10.1016/j.ijpara.2005.05.004
Effects of host-derived chemokines on the motility and viability of Trypanosoma brucei
10.1111/pim.12609
A Pre-clinical Animal Model of Trypanosoma brucei Infection Demonstrating Cardiac Dysfunction
10.1371/journal.pntd.0003811
Virulence in African Trypanosomes: Genetic and Molecular Approaches
10.1002/9781118308165.ch16
Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection
10.1128/IAI.00943-09
The population structure of the Cryptosporidium parvum population in Scotland: A complex picture
10.1016/j.meegid.2007.10.010
Trypanosoma brucei gambiense Type 1 populations from human patients are clonal and display geographical genetic differentiation
10.1016/j.meegid.2008.08.005
Development of a framework for genotyping bovine-derived Cryptosporidium parvum, using a multilocus fragment typing tool
10.1186/s13071-015-1107-8
Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: Chromosomal segregation, crossing over, and the construction of a genetic map
10.1186/gb-2008-9-6-r103
Trypanosomosis in the Gambia: Prevalence in working horses and donkeys detected by Whole Genome Amplification and PCR, and evidence for interactions between trypanosome species
10.1186/1746-6148-4-7
African trypanosomiasis
10.1111/j.1365-3024.2011.01302.x
Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms
10.1371/journal.pone.0058034
Trypanosoma brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes
10.1093/cvr/cvt187
The structure of a conserved telomeric region associated with variant antigen loci in the blood parasite trypanosoma congolense
10.1093/gbe/evy186
Using detergent to enhance detection sensitivity of African trypanosomes in human CSF and blood by loop-mediated isothermal amplification (LAMP)
10.1371/journal.pntd.0001249
A major genetic locus in Trypanosoma brucei is a determinant of host pathology
10.1371/journal.pntd.0000557
Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-γ response
10.1086/522011
Development of in vitro enteroids derived from bovine small intestinal crypts
10.1186/s13567-018-0547-5
The within-host dynamics of African trypanosome infections
10.1098/rstb.2014.0288
Parasite-driven pathogenesis in Trypanosoma brucei infections
10.1111/j.1365-3024.2011.01286.x
Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake
10.1016/j.ijpddr.2013.01.004
Development of multiple-locus variable-number tandem-repeat analysis for rapid genotyping of Ehrlichia ruminantium and its application to infected Amblyomma variegatum collected in heartwater endemic areas in Uganda
10.1017/S003118201100165X
DNA recombination strategies during antigenic variation in the african trypanosome
10.1128/microbiolspec.MDNA3-0016-2014
Exploiting genetic variation to discover genes involved in important disease phenotypes
10.1007/978-1-4939-1438-8_5
Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies
10.1186/s13567-017-0447-0
Discovery of mating in the major African livestock pathogen Trypanosoma congolense
10.1371/journal.pone.0005564
Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation
10.1073/pnas.0606206104
What the genome sequence is revealing about trypanosome antigenic variation
10.1042/BST20050986
Evidence of host-associated populations of Cryptosporidium parvum in Italy
10.1128/AEM.01451-12
Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction
10.1161/CIRCULATIONAHA.117.028911
Geostatistical models using remotely-sensed data predict savanna tsetse decline across the interface between protected and unprotected areas in Serengeti, Tanzania
10.1111/1365-2664.13091
Trypanosoma vivax displays a clonal population structure
10.1016/j.ijpara.2009.05.012
Analysis of host genetic factors influencing African trypanosome species infection in a cohort of Tanzanian Bos indicus cattle
10.1016/j.vetpar.2011.02.001
Population Genetics of Trypanosoma brucei rhodesiense: Clonality and Diversity within and between Foci
10.1371/journal.pntd.0002526
Inverted CD4+/CD8+ T cell ratio in Boran (Bos indicus) cattle
10.1016/j.vetimm.2020.110126
Influence of the Draining Lymph Nodes and Organized Lymphoid Tissue Microarchitecture on Susceptibility to Intradermal Trypanosoma brucei Infection
10.3389/fimmu.2020.01118
Molecular Dissection of the Antibody Response: Opportunities and Needs for Application in Cattle
10.3389/fimmu.2020.01175
To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host
10.3389/fimmu.2020.01250
Long-term production effects of clinical cryptosporidiosis in neonatal calves
10.1016/j.ijpara.2020.03.002
Developmental competence and antigen switch frequency can be uncoupled in Trypanosoma brucei
10.1073/pnas.1912711116
Assessing the effect of insecticide-treated cattle on tsetse abundance and trypanosome transmission at the wildlife-livestock interface in serengeti, tanzania
10.1371/journal.pntd.0008288
Molecular detection of 7SL-derived small RNA is a promising alternative for trypanosomosis diagnosis
10.1111/tbed.13744
Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections
10.1371/journal.pntd.0007262
Shiga toxin sub-type 2a increases the efficiency of Escherichia coli O157 transmission between animals and restricts epithelial regeneration in bovine enteroids
10.1371/journal.ppat.1008003
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
10.1371/journal.ppat.1008932
Development of a deep amplicon sequencing method to determine the species composition of piroplasm haemoprotozoa
10.1016/j.ttbdis.2019.101276
Emerging challenges in understanding trypanosome antigenic variation
10.1042/ETLS20170104
Evidence of host-associated populations of Cryptosporidium parvum in Italy
10.1128/AEM.07686-11
Contrasting population genetics of co-endemic cattle- and buffalo- derived Theileria annulata
10.1016/j.ttbdis.2020.101595
Andrew Pountain
Pountain Andrew
ORCID: 0000-0001-9651-5145
Population genomics reveals the origin and asexual evolution of human infective trypanosomes
10.7554/elife.11473
Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana
10.1371/journal.pntd.0005649
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge
10.1371/journal.pntd.0006052
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli
10.1371/journal.pone.0194126
Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana
10.1371/journal.ppat.1006953
Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites
10.1371/journal.pntd.0007052
Iminosugars counteract the downregulation of the interferon γ receptor by dengue virus
10.1016/j.antiviral.2019.104551
Untargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites
10.12688/wellcomeopenres.15452.1
The paralogous transcription factors Stp1 and Stp2 of Candida albicans have distinct functions in nutrient acquisition and host interaction
10.1128/iai.00763-19
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
10.1371/journal.ppat.1008932
Isabel Vincent
Vincent Isabel
ORCID: 0000-0003-2663-4389
TrypanoCyc: A community-led biochemical pathways database for Trypanosoma brucei
10.1093/nar/gku944
Metabolomic-based strategies for anti-parasite drug discovery
10.1177/1087057114551519
Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism
10.1016/j.ijpddr.2013.11.002
LM14 defined medium enables continuous growth of Trypanosoma cruzi
10.1186/s12866-014-0238-y
The threonine degradation pathway of the Trypanosoma brucei procyclic form: The main carbon source for lipid biosynthesis is under metabolic control
10.1111/mmi.12351
Pharmacological Metabolomics in Trypanosomes
10.1002/9783527670383.ch3
Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei
10.1371/journal.pntd.0001618
Drug resistance in human African trypanosomiasis
10.2217/fmb.11.88
A molecular mechanism for eflornithine resistance in African trypanosomes
10.1371/journal.ppat.1001204
Sixth Exploratory Measurement Science Group symposium
10.1586/epr.09.88
Polymeric hydrophilic interaction liquid chromatography coupled with Orbitrap mass spectrometry and chemometric analysis for untargeted metabolite profiling of natural rice variants
10.1016/j.jcs.2017.01.001
Untargeted metabolomics to ascertain antibiotic modes of action
10.1128/AAC.02109-15
Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis
10.1371/journal.pntd.0005140
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms
10.1371/journal.pntd.0005171
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing
10.1371/journal.ppat.1007315
Mitochondrial proteomics of antimony and miltefosine resistant Leishmania infantum
10.3390/proteomes3040328
Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
10.1371/journal.pntd.0006450
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
10.1371/journal.ppat.1006850
Chapter 6: Omics and Their Impact on the Development of Chemotherapy Against Leishmania
10.1039/9781788010177-00101
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli
10.1371/journal.pone.0194126
Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana
10.1371/journal.pntd.0005649
Decomposing metabolite set activity levels with PALS
10.1101/2020.06.07.138974
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
10.1371/journal.ppat.1008932
Ranking Metabolite Sets by Their Activity Levels
10.3390/metabo11020103
Justin van der Hooft
van der Hooft Justin
/ Justin J.J. van der Hooft
ORCID: 0000-0002-9340-5511
Structural elucidation of low abundant metabolites in complex sample matrices
10.1007/s11306-013-0519-8
Non-smoky GLYCOSYLTRANSFERASE1 prevents the release of smoky aroma from tomato fruit
10.1105/tpc.113.114231
Automatic chemical structure annotation of an LC-MSn based metabolic profile from green tea
10.1021/ac400861a
Substructure-based annotation of high-resolution multistage MSn spectral trees
10.1002/rcm.6364
Structural annotation and elucidation of conjugated phenolic compounds in black, green, and white tea extracts
10.1021/jf300297y
Structural elucidation and quantification of phenolic conjugates present in human urine after tea intake
10.1021/ac3017339
Spectral trees as a robust annotation tool in LC-MS based metabolomics
10.1007/s11306-011-0363-7
Metabolite identification using automated comparison of high-resolution multistage mass spectral trees
10.1021/ac2034216
Inhibitory activity of plumbagin produced by Drosera intermedia on food spoilage fungi
10.1002/jsfa.5522
A strategy for fast structural elucidation of metabolites in small volume plant extracts using automated MS-guided LC-MS-SPE-NMR
10.1002/mrc.2833
Thermal diffusivity of periderm from tomatoes of different maturity stages as determined by the concept of the frequency-domain open photoacoustic cell
10.1063/1.3530735
Polyphenol identification based on systematic and robust high-resolution accurate mass spectrometry fragmentation
10.1021/ac102546x
Iridoid and caffeoyl phenylethanoid glycosides of the endangered carnivorous plant Pinguicula lusitanica L. (Lentibulariaceae)
10.1016/j.bse.2009.05.003
Topic modeling for untargeted substructure exploration in metabolomics
10.1073/pnas.1608041113
Propagating annotations of molecular networks using in silico fragmentation
10.1371/journal.pcbi.1006089
Did a plant-herbivore arms race drive chemical diversity in Euphorbia?
10.1101/323014
Automatic Compound Annotation from Mass Spectrometry Data Using MAGMa.
10.5702/massspectrometry.S0033
Interactions of blacktea polyphenols with human gut microbiota: implications for gut and cardiovascular health
10.3945/ajcn.113.058263
Identification of a drimenol synthase and drimenol oxidase from Persicaria hydropiper, involved in the biosynthesis of insect deterrent drimanes
10.1111/tpj.13527
Enhanced Acylcarnitine Annotation in High-Resolution Mass Spectrometry Data: Fragmentation Analysis for the Classification and Annotation of Acylcarnitines
10.3389/fbioe.2015.00026
Rapid and sustained systemic circulation of conjugated gut microbiol catabolites after single-dose black tea extract consumption
10.1021/pr5001253
In Silico Prediction and Automatic LC–MSn Annotation of Green Tea Metabolites in Urine
10.1021/ac403875b
Unexpected differential metabolic responses of Campylobacter jejuni to the abundant presence of glutamate and fucose
10.1007/s11306-018-1438-5
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae
10.1101/463620
Deciphering complex metabolite mixtures by unsupervised and supervised substructure discovery and semi-automated annotation from MS/MS spectra
10.1101/491506
Accelerating metabolite identification in natural product research: toward an ideal combination of LC-HRMS/MS and NMR profiling, in silico databases and chemometrics
10.1021/acs.analchem.8b05112
Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages
10.1101/347716
Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings
https://doi.org/10.1016/j.mam.2017.11.002
Metabolite Identification in Complex Mixtures Using Nuclear Magnetic Resonance Spectroscopy
10.1007/978-3-319-28275-6_6-2
Ms2lda.org: web-based topic modelling for substructure discovery in mass spectrometry
10.1093/bioinformatics/btx582
A comprehensive evaluation of the [2-14C](–)-epicatechin metabolome in rats
https://doi.org/10.1016/j.freeradbiomed.2016.08.001
The food metabolome: a window over dietary exposure
10.3945/ajcn.113.076133
Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols
10.3945/ajcn.113.058958
Unsupervised Discovery and Comparison of Structural Families Across Multiple Samples in Untargeted Metabolomics
10.1021/acs.analchem.7b01391
A community-driven paired data platform to accelerate natural product mining by combining structural information from genomes and metabolomes
10.18174/FAIRdata2018.16286
Implementations of the chemical structural and compositional similarity metric in R and Python
10.1101/546150
Comprehensive mass spectrometry-guided phenotyping of plant specialized metabolites reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae
10.1111/tpj.14292
A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters
10.1186/s13104-019-4222-3
The Metabolomics Society—Current State of the Membership and Future Directions
10.3390/metabo9050089
Deciphering complex metabolite mixtures by unsupervised and supervised substructure discovery and semi-automated annotation from MS/MS spectra
10.1039/C8FD00235E
MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools
10.1101/654459
Substantial extracellular metabolic differences found between phylogenetically closely related probiotic and pathogenic strains of Escherichia coli
10.3389/fmicb.2019.00252
Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia l.
10.3389/fpls.2019.00846
Molnetenhancer: Enhanced molecular networks by integrating metabolome mining and annotation tools
10.3390/metabo9070144
In Silico Optimization of Mass Spectrometry Fragmentation Strategies in Metabolomics
10.3390/metabo9100219
MIBiG 2.0: a repository for biosynthetic gene clusters of known function
10.1093/nar/gkz882
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages
10.1016/j.foodchem.2019.125290
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery
10.1021/acscentsci.9b00806
Mass spectrometry searches using MASST
10.1038/s41587-019-0375-9
Assessing specialized metabolite diversity of Alnus species by a digitized LC–MS/MS data analysis workflow
10.1016/j.phytochem.2020.112292
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication
10.1126/sciadv.aax6328
Chemically-informed Analyses of Metabolomics Mass Spectrometry Data with Qemistree
10.1101/2020.05.04.077636
Linking genomics and metabolomics to chart specialized metabolic diversity
10.1039/D0CS00162G
Reproducible molecular networking of untargeted mass spectrometry data using GNPS
10.1038/s41596-020-0317-5
Decomposing metabolite set activity levels with PALS
10.1101/2020.06.07.138974
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions
10.1101/2020.06.12.148205
Phenylpropane as an Alternative Dearomatizing Unit of Indoles: Discovery of Inaequalisines A and B Using Substructure-Informed Molecular Networking
10.1021/acs.orglett.0c02153
matchms - processing and similarity evaluation of mass spectrometry data
10.1101/2020.08.06.239244
Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships
10.1101/2020.08.11.245928
BiG-SLiCE: A Highly Scalable Tool Maps the Diversity of 1.2 Million Biosynthetic Gene Clusters
10.1101/2020.08.17.240838
matchms - processing and similarity evaluation of mass spectrometry data.
10.21105/joss.02411
ReDU: a framework to find and reanalyze public mass spectrometry data
10.1038/s41592-020-0916-7
Feature-based molecular networking in the GNPS analysis environment
10.1038/s41592-020-0933-6
Rapid Development of Improved Data-dependent Acquisition Strategies
10.1101/2020.09.11.293092
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree
10.1038/s41589-020-00677-3
Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data
10.1038/s41587-020-0700-3
The ant fungus garden acts as an external digestive system
10.1101/2020.11.18.389361
BiG-MAP: an automated pipeline to profile metabolic gene cluster abundance and expression in microbiomes
10.1101/2020.12.14.422671
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters
10.1093/gigascience/giaa154
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
10.1371/journal.ppat.1008932
Comparative Metabologenomics Analysis of Polar Actinomycetes
10.3390/md19020103
Ranking Metabolite Sets by Their Activity Levels
10.3390/metabo11020103
Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships
10.1371/journal.pcbi.1008724
Rapid Development of Improved Data-Dependent Acquisition Strategies
10.1021/acs.analchem.0c03895
MS2DeepScore - a novel deep learning similarity measure for mass fragmentation spectrum comparisons
10.1101/2021.04.18.440324
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions
10.1371/journal.pcbi.1008920
Metabolomics-Guided Elucidation of Plant Abiotic Stress Responses in the 4IR Era: An Overview
10.3390/metabo11070445
Chemical Gradients of Plant Substrates in an Atta texana Fungus Garden
10.1128/mSystems.00601-21
Comprehensive Large-Scale Integrative Analysis of Omics Data To Accelerate Specialized Metabolite Discovery
10.1128/mSystems.00726-21
Federica Giordani
Giordani Federica
ORCID: 0000-0001-9964-281X
New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story
10.3390/tropicalmed5010029
Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model.
10.1021/acs.jmedchem.8b01847
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.
10.1371/journal.ppat.1007315
Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.
10.1371/journal.pntd.0006450
An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics.
10.1016/j.ejmech.2017.05.039
Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease.
10.1017/S003118201600202X
The animal trypanosomiases and their chemotherapy: a review.
10.1017/S0031182016001268
An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics.
10.1016/j.ejmech.2016.03.064
Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis.
10.1128/AAC.01449-13
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.
10.1021/jm500483b
Green fluorescent diamidines as diagnostic probes for trypanosomes.
10.1128/AAC.02024-13
Synthesis, characterization and deepening in the comprehension of the biological action mechanisms of a new nickel complex with antiproliferative activity.
10.1016/j.jinorgbio.2008.12.016
Cytotoxic and genotoxic potential of drinking water: a comparison between two different concentration methods.
10.1016/j.watres.2007.12.005
Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles.
10.1039/b710487a
Trypanocidal nitroimidazole derivatives: relationships among chemical structure and genotoxic activity.
10.1016/j.bcp.2007.01.024
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.
10.1371/journal.ppat.1008932
