A molecular mechanism for eflornithine resistance in African trypanosomes
Isabel M. Vincent
Darren Creek
David G. Watson
Mohammed A. Kamleh
Debra J. Woods
Pui Ee Wong
Richard J. S. Burchmore
Michael P. Barrett
Marilyn Parsons
PLoS Pathogens, 2010
Richard Burchmore
Burchmore Richard
ORCID: 0000-0003-1663-9004
Integration of proteomics and metabolomics to elucidate metabolic adaptation in Leishmania
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A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes
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Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
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Gentamicin-Attenuated Leishmania infantum Vaccine: Protection of Dogs against Canine Visceral Leishmaniosis in Endemic Area of Southeast of Iran
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Hexose Transport in Asexual Stages of Plasmodium falciparum and Kinetoplastidae
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The plasma proteome and acute phase proteins of broiler chickens with gait abnormalities
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Dogs vaccinated with gentamicin-attenuated Leishmania infantum or infected with wild-type parasite can be distinguished by Western blotting
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PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast
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Vaccination with Recombinant Leishmania donovani Gamma-Glutamylcysteine Synthetase Fusion Protein Protects Against L. donovani Infection
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Multiple Genetic Mechanisms Lead to Loss of Functional TbAT1 Expression in Drug-Resistant Trypanosomes
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Enhancing the egg's natural defence against bacterial penetration by increasing cuticle deposition
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Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules
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Loss of the High-Affinity Pentamidine Transporter Is Responsible for High Levels of Cross-Resistance between Arsenical and Diamidine Drugs in African Trypanosomes
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Cloning, Heterologous Expression, and in Situ Characterization of the First High Affinity Nucleobase Transporter from a Protozoan
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Modulation of the Host Cell Proteome by the Intracellular Apicomplexan Parasite Toxoplasma gondii
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Genetic characterization of glucose transporter function in Leishmania mexicana
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Quantitative proteomic profiling of bovine follicular fluid during follicle development†
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Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
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Essential roles for deubiquitination in Leishmania life cycle progression
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Darren Creek
Creek Darren
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Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose
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BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei
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Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei
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Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
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Discovery and Validation of Clinical Biomarkers of Cancer: A Review Combining Metabolomics and Proteomics
10.1002/pmic.201700448
Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa
10.1128/mSystems.00149-18
Metabolomics Databases
10.1002/9780471650126.dob0981
Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics
10.3390/metabo6040032
Metabolomics continues to expand: highlights from the 2015 metabolomics conference
10.1007/s11306-015-0846-z
Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study
10.3389/fphar.2018.00359
NormalizeMets: assessing, selecting and implementing statistical methods for normalizing metabolomics data
10.1007/s11306-018-1347-7
Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii
10.3389/fmicb.2018.02776
Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate
10.7554/elife.23217
Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii
10.1038/srep45527
Pharmacological Metabolomics in Trypanosomes
10.1002/9783527670383.ch3
The Role of Metabolomics in Antiparasitic Drug Discovery
10.1002/9783527694082.ch14
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy
10.1016/j.ijpddr.2017.04.003
Multi-omics based identification of specific biochemical changes associated with PfKelch13-mutant artemisinin-resistant plasmodium falciparum
10.1093/infdis/jix156
Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana
10.1371/journal.pntd.0005649
A high parasite density environment induces transcriptional changes and cell death in Plasmodium falciparum blood stages
10.1111/febs.14370
Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated with Artemether-Lumefantrine for Uncomplicated Malaria
10.1093/infdis/jiw338
Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis
10.1073/pnas.1523116113
Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii
10.1038/ja.2015.127
Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)
10.1039/c8nr00835c
Mass appeal: Metabolite identification in mass spectrometry-focused untargeted metabolomics
10.1007/s11306-012-0434-4
Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa
10.1016/j.csbj.2018.11.001
An oncogenic role for sphingosine kinase 2
10.18632/oncotarget.11714
Metabolite identification: are you sure? And how do your peers gauge your confidence?
10.1007/s11306-014-0656-8
Global gene expression profile of acinetobacter baumannii during bacteremia
10.1093/infdis/jiw529
Pyrimidine salvage in trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines
10.1124/mol.112.082321
Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide
10.1007/s11306-016-1062-1
Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles
10.1002/smll.201701528
3, 3’-Disubstituted 5, 5’-Bi (1, 2, 4-triazine) derivatives with Potent in vitro and in vivo Antimalarial Activity
10.1021/acs.jmedchem.8b01799
Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria
10.1016/j.pt.2019.05.002
Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions
10.1021/acsinfecdis.9b00093
The Development Process for Discovery and Clinical Advancement of Modern Antimalarials
10.1021/acs.jmedchem.9b00761
Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa
10.1128/AAC.01587-19
Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum
10.1021/acsinfecdis.9b00257
Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum
10.1074/mcp.ra119.001797
Using the IDEOM Workflow for LCMS-Based Metabolomics Studies of Drug Mechanisms
10.1007/978-1-0716-0239-3_21
Global Metabolic Analyses of Acinetobacter baumannii
10.1007/978-1-4939-9118-1_28
Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa.
10.3389/fphar.2019.01146
Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii.
10.3389/fphar.2019.00754
Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method
10.3390/molecules25040829
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion
10.1101/2020.03.23.003376
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion
10.1371/journal.ppat.1008485
Metabolomes and Lipidomes of the Infective Stages of the Gastrointestinal nematodes, Nippostrongylus brasiliensis and Trichuris muris
10.3390/metabo10110446
Off-label prescribing in the midst of a pandemic: The case of hydroxychloroquine
10.31128/ajgp-covid-06
Sulfoxide‐Containing Polymer‐Coated Nanoparticles Demonstrate Minimal Protein Fouling and Improved Blood Circulation
10.1002/advs.202000406
Lipid A profiling and metabolomics analysis of paired polymyxin-susceptible and -resistant MDR Klebsiella pneumoniae clinical isolates from the same patients before and after colistin treatment
10.1093/jac/dkaa245
Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
10.1186/s12915-020-00791-7
Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
10.1038/s41467-020-16568-z
Polymyxins Bind to the Cell Surface of Unculturable
Acinetobacter baumannii
and Cause Unique Dependent Resistance
10.1002/advs.202000704
Retargeting azithromycin analogues to have dual-modality antimalarial activity
10.1186/s12915-020-00859-4
Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury
10.1093/toxsci/kfab069
β-Adrenoceptor regulation of metabolism in U937 derived macrophages
10.1039/D1MO00057H
Polymyxin-Induced Metabolic Perturbations in Human Lung Epithelial Cells
10.1128/AAC.00835-21
Isabel Vincent
Vincent Isabel
ORCID: 0000-0003-2663-4389
TrypanoCyc: A community-led biochemical pathways database for Trypanosoma brucei
10.1093/nar/gku944
Metabolomic-based strategies for anti-parasite drug discovery
10.1177/1087057114551519
Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism
10.1016/j.ijpddr.2013.11.002
LM14 defined medium enables continuous growth of Trypanosoma cruzi
10.1186/s12866-014-0238-y
The threonine degradation pathway of the Trypanosoma brucei procyclic form: The main carbon source for lipid biosynthesis is under metabolic control
10.1111/mmi.12351
Pharmacological Metabolomics in Trypanosomes
10.1002/9783527670383.ch3
Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei
10.1371/journal.pntd.0001618
Drug resistance in human African trypanosomiasis
10.2217/fmb.11.88
A molecular mechanism for eflornithine resistance in African trypanosomes
10.1371/journal.ppat.1001204
Sixth Exploratory Measurement Science Group symposium
10.1586/epr.09.88
Polymeric hydrophilic interaction liquid chromatography coupled with Orbitrap mass spectrometry and chemometric analysis for untargeted metabolite profiling of natural rice variants
10.1016/j.jcs.2017.01.001
Untargeted metabolomics to ascertain antibiotic modes of action
10.1128/AAC.02109-15
Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis
10.1371/journal.pntd.0005140
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms
10.1371/journal.pntd.0005171
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing
10.1371/journal.ppat.1007315
Mitochondrial proteomics of antimony and miltefosine resistant Leishmania infantum
10.3390/proteomes3040328
Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
10.1371/journal.pntd.0006450
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
10.1371/journal.ppat.1006850
Chapter 6: Omics and Their Impact on the Development of Chemotherapy Against Leishmania
10.1039/9781788010177-00101
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli
10.1371/journal.pone.0194126
Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana
10.1371/journal.pntd.0005649
Decomposing metabolite set activity levels with PALS
10.1101/2020.06.07.138974
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
10.1371/journal.ppat.1008932
Ranking Metabolite Sets by Their Activity Levels
10.3390/metabo11020103
Mike Barrett
Barrett Mike
ORCID: 0000-0001-9447-3519
Why aren't we doing more to safeguard vulnerable adults from thermal injuries?
10.1016/j.neurobiola.08.018
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.
10.1073/pnas.1505411112
Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites.
10.1371/journal.ppat.1004882
An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei.
10.1371/journal.ppat.1004875
Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.
10.1371/journal.pntd.0003714
Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose.
10.1371/journal.ppat.1004689
Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines.
10.3389/fbioe.2015.00026
Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool.
10.1128/AAC.05046-14
Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.
10.1021/bi501366a
Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione.
10.1124/mol.114.096016
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
10.1093/nar/gku944
Metabolomic-based strategies for anti-parasite drug discovery.
10.1177/1087057114551519
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.
10.1021/jm500483b
BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei.
10.1371/journal.ppat.1004263
Trypanosoma brucei: meet the system.
10.1016/j.mib.2014.06.007
Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis.
10.1128/AAC.01449-13
Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.
10.1371/journal.pntd.0002844
Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics.
10.1002/anie.201310401
Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks.
10.4155/bio.13.348
Emerging paradigms in anti-infective drug design.
10.1017/S0031182013001224
The silicon trypanosome: a test case of iterative model extension in systems biology.
10.1016/B978-0-12-800143-1.00003-8
Shape-dependent optoelectronic cell lysis.
10.1002/anie.201307751
Green fluorescent diamidines as diagnostic probes for trypanosomes.
10.1128/AAC.02024-13
Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei.
10.1371/journal.pcbi.1003371
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
10.1093/jac/dkt442
A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity.
10.1371/journal.ppat.1003731
The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control.
10.1111/mmi.12351
In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis.
10.1371/journal.pntd.0002384
Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis.
10.1111/febs.12436
Determination of antiprotozoal drug mechanisms by metabolomics approaches.
10.1017/S0031182013000814
Metabolite-dependent regulation of gene expression in Trypanosoma brucei.
10.1111/mmi.12243
Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei.
10.1128/AAC.00044-13
Minor groove binders as anti-infective agents.
10.1016/j.pharmthera.2013.03.002
Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake.
10.1016/j.ijpddr.2013.01.004
The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii.
10.1111/mmi.12139
mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data.
10.1093/bioinformatics/bts674
Management of trypanosomiasis and leishmaniasis.
10.1093/bmb/lds031
Counterflow dielectrophoresis for trypanosome enrichment and detection in blood.
10.1038/srep00775
Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation.
10.1021/ac3018795
Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT.
10.1016/j.bmc.2012.08.049
Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.
10.1002/cmdc.201200304
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
10.1073/pnas.1202885109
Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.
10.1371/journal.pntd.0001618
IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data.
10.1093/bioinformatics/bts069
Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine.
10.1021/ac2030738
Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism.
10.1371/journal.pcbi.1002352
A comparison of leg length and femoral offset discrepancies in hip resurfacing, large head metal-on- metal and conventional total hip replacement: a case series.
10.1186/1749-799X-6-65
Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry.
10.1002/rcm.5247
Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry.
10.1002/rcm.5245
Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction.
10.1021/ac2021823
Metabolomic analysis of trypanosomatid protozoa.
10.1016/j.molbiopara.2011.10.003
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.
10.1371/journal.pntd.0001308
Drug resistance in human African trypanosomiasis.
10.2217/fmb.11.88
Development of novel drugs for human African trypanosomiasis.
10.2217/fmb.11.44
Transketolase in Trypanosoma brucei.
10.1016/j.molbiopara.2011.04.006
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.
10.1124/mol.111.071555
Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry.
10.1002/rcm.4939
Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.
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A glucose transporter can mediate ribose uptake.: DEFINITION OF RESIDUES THAT CONFER SUBSTRATE SPECIFICITY IN A SUGAR TRANSPORTER.
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Separation of parasites from human blood using deterministic lateral displacement.
10.1039/c0lc00560f
Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity.
10.1016/j.bmc.2011.01.010
Synthesis and in vitro/in vivo evaluation of the antitrypanosomal activity of 3-bromoacivicin, a potent CTP synthetase inhibitor.
10.1002/cmdc.201000417
The 6-phosphogluconate dehydrogenase of Leishmania (Leishmania) mexicana: gene characterization and protein structure prediction.
10.1159/000320697
Potential new drugs for human African trypanosomiasis: some progress at last.
10.1097/QCO.0b013e32833f9fd0
A molecular mechanism for eflornithine resistance in African trypanosomes.
10.1371/journal.ppat.1001204
Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds.
10.1021/jm1004754
A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes.
10.1016/j.molbiopara.2010.07.002
A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter.
10.1074/jbc.M110.106815
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.
10.1016/j.bmcl.2010.06.070
Multiple roles of proline transport and metabolism in trypanosomatids.
10.2741/3931
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.
10.1016/j.bmc.2010.05.077
The silicon trypanosome.
10.1017/S0031182010000466
MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks.
10.1093/nar/gkq312
Metabolomic systems biology of trypanosomes.
10.1017/S003118201000017X
Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining.
10.1007/s11306-009-0196-9
Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.
10.1128/EC.00200-09
Predictive computational models of substrate binding by a nucleoside transporter.
10.1074/jbc.M109.049726
Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal.
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The Toxoplasma gondii plastid replication and repair enzyme complex, PREX.
10.1017/S0031182009006027
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
10.1093/brain/awp074
Unsaturated Mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains.
10.1002/cmdc.200800360
Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.
10.1016/j.bmc.2009.01.058
Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites.
10.1039/b813394h
Paromomycin: uptake and resistance in Leishmania donovani.
10.1016/j.molbiopara.2008.12.007
The natural progression of Gambiense sleeping sickness: what is the evidence?
10.1371/journal.pntd.0000303
Increasing the mass accuracy of high-resolution LC-MS data using background ions: a case study on the LTQ-Orbitrap.
10.1002/pmic.200800314
Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis.
10.1016/j.bmcl.2008.09.047
Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.
10.1128/AAC.01450-07
Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules.
10.1002/rcm.3564
Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei.
10.1074/jbc.M709592200
N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift.
10.1017/S0031182008004241
African sleeping sickness.
10.1136/bmj.39505.490544.BE
Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.
10.1016/j.bmcl.2008.02.037
New surveyor tools for charting microbial metabolic maps.
10.1038/nrmicro1797
MetaNetter: inference and visualization of high-resolution metabolomic networks.
10.1093/bioinformatics/btm536
A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase.
10.1016/j.jprot.2007.11.002
Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles.
10.1039/b710487a
McArthur revisited: fluorescence microscopes for field diagnostics.
10.1016/j.pt.2007.08.003
Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.
10.1002/cmdc.200700040
Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.
10.1038/sj.bjp.0707354
Molecular cloning, expression and characterization of ribokinase of Leishmania major.
10.1111/j.1745-7270.2007.00298.x
Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates.
10.1111/j.1742-4658.2006.05585.x
Precision mapping of the metabolome.
10.1016/j.tibtech.2006.10.006
Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance.
10.1124/mol.106.024653
DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.
10.1021/jm060295c
The rise and fall of sleeping sickness.
10.1016/S0140-6736(06)68591-7
Targeting of toxic compounds to the trypanosome's interior.
10.1016/S0065-308X(06)63002-9
Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter.
10.1128/AAC.49.12.5169-5171.2005
Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani.
10.1016/j.molbiopara.2005.08.016
Chemotherapy of trypanosomiases and leishmaniasis.
10.1016/j.pt.2005.08.026
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
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Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test.
10.1016/S0140-6736(05)66793-1
The plastidic DNA replication enzyme complex of Plasmodium falciparum.
10.1016/j.molbiopara.2005.02.002
Energy generation in insect stages of Trypanosoma brucei: metabolism in flux.
10.1016/j.pt.2005.02.008
Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose.
10.1074/jbc.M414274200
Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites.
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6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes.
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Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
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Trypanocidal activity of melamine-based nitroheterocycles.
10.1128/AAC.48.5.1733-1738.2004
The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.
10.1128/AAC.48.5.1515-1519.2004
Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter.
10.1016/j.bcp.2003.09.005
The trypanosomiases.
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Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.
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Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
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Pentose phosphate metabolism in Leishmania mexicana.
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Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis.
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Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines.
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Waking up to sleeping sickness.
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Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.
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Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan.
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Genetic characterization of glucose transporter function in Leishmania mexicana.
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Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.
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Polymorphism among alleles of the 6-phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica.
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Perspectives for new drugs against trypanosomiasis and leishmaniasis.
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Sleeping sickness and the brain.
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