High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling
Brodin, P. Poquet, Y. Levillain, F. Peguillet, I. Larrouy-Maumus, G. Gilleron, M. Ewann, F. Christophe, T. Fenistein, D. Jang, J. C. Jang, M. S. Park, S. J. Rauzier, J. Carralot, J. P. Shrimpton, R. Genovesio, A. Gonzalo-Asensio, J. A. Puzo, G. Martin, C. Brosch, R. Stewart, G. R. Gicquel, B. Neyrolles, O.
Plos Pathogens, 2010
https://doi.org/10.1371/journal.ppat.1001100
Graham Stewart
Stewart Graham
ORCID: 0000-0002-6867-6248
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Martine GILLERON
GILLERON Martine
ORCID: 0000-0002-2581-3302
Email: margilleron@gmail.com
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Priscille Brodin
Brodin Priscille
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Email: priscille.brodin@inserm.fr
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Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129
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Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902
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A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J
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Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82
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Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505
Carlos Martin
Martin Carlos / RID: A-7283-2008
ORCID: 0000-0003-2993-5478
Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials 10.1016/j.vaccine.2013.07.051
ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis 10.1111/cmi.12169
Global Study of IS6110 in a Successful Mycobacterium tuberculosis Strain: Clues for Deciphering Its Behavior and for Its Rapid Detection 10.1128/JCM.00970-13
Mapping IS6110 in high-copy number Mycobacterium tuberculosis strains shows specific insertion points in the Beijing genotype 10.1186/1471-2164-14-422
Recent developments in tuberculosis vaccines 10.1586/14760584.2013.856765
Attenuated Mycobacterium tuberculosis SO2 Vaccine Candidate Is Unable to Induce Cell Death 10.1371/journal.pone.0045213
Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain 10.1016/j.meegid.2011.06.006
Functional and Genetic Characterization of the Tap Efflux Pump in Mycobacterium bovis BCG 10.1128/AAC.05946-11
IS-seq: a novel high throughput survey of in vivo IS6110 transposition in multiple Mycobacterium tuberculosis genomes 10.1186/1471-2164-13-249
Long-term molecular surveillance of multidrug-resistant tuberculosis in Spain 10.1016/j.meegid.2011.05.016
Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4 + T-cell memory 10.1002/eji.201141903
Rapid Test for Identification of a Highly Transmissible Mycobacterium tuberculosis Beijing Strain of Sub-Saharan Origin 10.1128/JCM.06314-11
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237 10.1016/j.tube.2010.12.007
The Transcriptional Regulatory Network of Mycobacterium tuberculosis 10.1371/journal.pone.0022178
Drug-resistant tuberculosis in the European Union: Opportunities and challenges for control 10.1016/j.tube.2010.03.008
High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100
Interactions of Attenuated Mycobacterium tuberculosis phoP Mutant with Human Macrophages 10.1371/journal.pone.0012978
Extended safety studies of the attenuated live tuberculosis vaccine SO2 based on phoP mutant 10.1016/j.vaccine.2009.02.060
Multidrug-Resistant Mycobacterium tuberculosis Strain from Equatorial Guinea Detected in Spain 10.3201/eid1511.090449
MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques 10.1371/journal.pone.0005264
Role of the Mycobacterium tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth 10.1128/AAC.00550-09
A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra 10.1128/JB.01465-07
Attenuated strains of Mycobacterium tuberculosis complex for laboratory and clinical use 10.1016/j.tube.2008.04.004
Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033
Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials 10.1517/14712598.8.2.201
Mapping of IS6110 insertion sites in Mycobacterium bovis isolates in relation to adaptation from the animal to human host 10.1016/j.vetmic.2007.11.038
PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence 10.1371/journal.pone.0003496
The Mycobacterium tuberculosis phoPR Operon Is Positively Autoregulated in the Virulent Strain H37Rv 10.1128/JB.00712-08
Transcriptional analysis of and resistance level conferred by the aminoglycoside acetyltransferase gene aac(2′)-Id from Mycobacterium smegmatis 10.1093/jac/dkm440
Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG 10.1093/jac/dkl510
Immunological responses and protective immunity against tuberculosis conferred by vaccination of Balb/C mice with the attenuated Mycobacterium tuberculosis (phoP) SO2 strain 10.1111/j.1365-2249.2006.03284.x
Multidrug-resistant Mycobacterium tuberculosis Beijing/W genotype in Venezuela 10.1099/jmm.0.47310-0
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Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitum 10.1093/jac/dki436
Molecular characterisation of Mycobacterium tuberculosis isolates in the first national survey of anti-tuberculosis drug resistance from Venezuela 10.1186/1471-2180-6-90
Novel streptomycin resistance gene from Mycobacterium fortuitum 10.1128/AAC.00223-06
The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs 10.1016/j.vaccine.2006.03.017
The use of mutant mycobacteria as new vaccines to prevent tuberculosis 10.1016/j.tube.2006.01.022
The virulence-associated twocomponent PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis 10.1074/jbc.C500388200
Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis 10.1016/j.tube.2004.09.009
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Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice 10.1016/j.vaccine.2014.07.047
Pulmonary Mycobacterium bovis BCG Vaccination Confers Dose-Dependent Superior Protection Compared to That of Subcutaneous Vaccination 10.1128/CVI.00700-13
Single nucleotide polymorphism (SNP) analysis used for the phylogeny of the Mycobacterium tuberculosis complex based on a pyrosequencing assay 10.1186/1471-2180-14-21
The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis 10.1371/journal.ppat.1004183
Neutral-red reaction is related to virulence and cell wall methyl-branched lipids in Mycobacterium tuberculosis 10.1016/j.micinf.2005.06.011
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Intracellular replication of attenuated Mycobacterium tuberculosis phoP mutant in the absence of host cell cytotoxicity 10.1016/j.micinf.2008.10.013
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Use of conjugative and thermosensitive cloning vectors for transposon delivery to Mycobacterium smegmatis 10.1016/0378-1097(95)00032-Z
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Analysis of the regions responsible for IS6110 RFLP in a single Mycobacterium tuberculosis strain 10.1016/0923-2508(92)90104-V
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Evaluation of the immunogenicity and diagnostic interference caused by M-tuberculosis SO2 vaccination against tuberculosis in goats 10.1016/j.rvsc.2015.09.017
Construction of a family of Mycobacterium/Escherichia coli shuttle vectors derived from pAL5000 and pACYC184: Their use for cloning an antibiotic-resistance gene from Mycobacterium fortuitum 10.1016/0378-1119(96)00202-8
Detection of a Putative TetR-Like Gene Related to Mycobacterium bovis BCG Growth in Cholesterol Using a gfp-Transposon Mutagenesis System 10.3389/fmicb.2017.00315
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Vaccination Against Tuberculosis With Whole-Cell Mycobacterial Vaccines 10.1093/infdis/jiw228
Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis 10.1038/ncomms16085
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MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic 10.3389/fimmu.2017.01803
Data-driven model for the assessment of Mycobacterium tuberculosis transmission in evolving demographic structures 10.1073/pnas.1720606115
New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages 10.1371/journal.pgen.1007282
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A Mycobacterium tuberculosis Beijing strain persists at high rates and extends its geographic boundaries 20 years after importation 10.1038/s41598-019-40525-6
Mycobacterium tuberculosis infection prevents asthma and abrogates eosinophilopoiesis in an experimental model 10.1111/all.13923
Bridging the gap between efficacy trials and model-based impact evaluation for new tuberculosis vaccines 10.1038/s41467-019-13387-9
Update on TB Vaccine Pipeline 10.3390/app10072632
Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential 10.1016/j.ebiom.2020.102761
New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia 10.1371/journal.ppat.1008404
Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference 10.1371/journal.ppat.1009061
Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment. 10.1016/j.ebiom.2020.103186
MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies. 10.1038/s41541-020-00262-8
Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination. 10.1016/j.xcrm.2020.100185
Pulmonary MTBVAC vaccination induces immune signatures previously correlated with prevention of tuberculosis infection. 10.1016/j.xcrm.2020.100187
MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG 10.1016/j.vaccine.2021.06.049
Nathalie deboosere
deboosere Nathalie
ORCID: 0000-0002-2873-5485
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 10.1016/j.celrep.2017.08.101
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. 10.3390/toxins9070227
Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. 10.1021/acschembio.7b00091
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. 10.1111/cmi.12619
A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114
Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces. 10.1016/j.fm.2012.04.007
Viral elution and concentration method for detection of influenza A viruses in mud by real-time RT-PCR. 10.1016/j.jviromet.2011.10.013
Comparison of chlorine and peroxyacetic-based disinfectant to inactivate Feline calicivirus, Murine norovirus and Hepatitis A virus on lettuce. 10.1016/j.ijfoodmicro.2011.08.011
Direct detection of highly pathogenic avian influenza A/H5N1 virus from mud specimens. 10.1016/j.jviromet.2011.06.002
Development and validation of a concentration method for the detection of influenza a viruses from large volumes of surface water. 10.1128/aem.02484-10
A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries. 10.1016/j.fm.2010.05.018
Assessment of the removal and inactivation of influenza viruses H5N1 and H1N1 by drinking water treatment. 10.1016/j.watres.2010.01.013
Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables. 10.1016/j.ijfoodmicro.2005.11.007
Modelling effect of physical and chemical parameters on heat inactivation kinetics of hepatitis A virus in a fruit model system. 10.1016/j.ijfoodmicro.2003.10.015
Host-pathogen systems for early drug discovery against tuberculosis. 10.1016/j.mib.2017.11.017
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids. 10.1073/pnas.1707840114
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. 10.1038/s41598-017-11843-4
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages. 10.1016/j.chom.2017.07.020
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-017-05453-3
Host-directed therapies offer novel opportunities for the fight against tuberculosis. 10.1016/j.drudis.2017.05.005
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs. 10.1016/j.ijpharm.2017.05.030
Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis. 10.3389/fcimb.2017.00137
Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections. 10.2217/nnm-2016-0364
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. 10.1126/science.aag1006
How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 10.1007/s00401-016-1652-z
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535
Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization. 10.1016/j.str.2016.07.009
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro. 10.1007/s00705-016-2771-5
[Mycolactone: the amazing analgesic mycobacterial toxin]. 10.1051/medsci/20163202007
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. 10.1039/c5ob02630j
Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action. 10.1128/jvi.01473-15
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system. 10.1016/j.vaccine.2015.03.083
Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo. 10.1371/journal.ppat.1004650
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Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays. 10.1007/978-1-4939-2450-9_24
2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1. 10.1021/cb5007163
High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis. 10.1128/aac.03705-14
Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways. 10.1016/j.cell.2014.04.040
Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches. 10.1021/jm500422b
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262
The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence. 10.1371/journal.pone.0047573
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors. 10.1021/jm200825u
A novel specific edge effect correction method for RNA interference screenings. 10.1093/bioinformatics/btr648
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis. 10.1371/journal.pone.0026675
High-content screening in infectious diseases. 10.1016/j.cbpa.2011.05.023
Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors. 10.1021/jm200076a
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. 10.1371/journal.ppat.1001100
High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery. 10.4155/fmc.10.223
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ. 10.1099/mic.0.038133-0
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. 10.1371/journal.ppat.1000645
Systematic genetic nomenclature for type VII secretion systems. 10.1371/journal.ppat.1000507
Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. 10.1016/j.biomaterials.2009.09.044
Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. 10.1126/science.1171583
Automated high-throughput siRNA transfection in raw 264.7 macrophages: a case study for optimization procedure. 10.1177/1087057108328762
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. 10.1371/journal.ppat.0040033
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. 10.1128/jb.00469-07
[Aquatic insects and transmission of Mycobacterium ulcerans]. 10.1051/medsci/20072367572
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis. 10.1371/journal.ppat.0030062
Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva. 10.1371/journal.pmed.0040064
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues. 10.1016/j.bmc.2006.12.009
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence. 10.1128/jb.00631-06
High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection. 10.1128/iai.02086-05
Benzofuro[3,2-f][1]benzopyrans: a new class of antitubercular agents. 10.1016/j.bmc.2006.03.033
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis. 10.1128/iai.74.4.2128-2137.2006
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. 10.1128/iai.74.1.88-98.2006
Tuberculosis: from genome to vaccine. 10.1586/14760584.4.4.541
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity. 10.1074/jbc.m503515200
Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics. 10.1099/mic.0.27799-0
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. 10.1016/j.tube.2004.09.009
ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens. 10.1086/421468
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6. 10.1128/iai.72.4.2170-2176.2004
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex. 10.1099/mic.0.26662-0
CD8+-T-cell responses of Mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family. 10.1128/iai.71.12.7173-7177.2003
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. 10.1038/nm859
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. 10.1046/j.1365-2958.2002.03237.x
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. 10.1128/iai.70.10.5568-5578.2002
Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides. 10.1021/bi015732y
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551
Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483
Jesús Gonzalo-Asensio
Gonzalo-Asensio Jesús
ORCID: 0000-0001-8841-6593
A Novel Antisense RNA from the Salmonella Virulence Plasmid pSLT Expressed by Non-Growing Bacteria inside Eukaryotic Cells. 10.1371/journal.pone.0077939
Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials. 10.1016/j.vaccine.2013.07.051
Recent developments in tuberculosis vaccines. 10.1586/14760584.2013.856765
The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis. 10.1371/journal.ppat.1004183
A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component 10.1128/IAI.01824-14
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator 10.1073/pnas.1406693111
(Aminophosphane)gold(I) and silver(I) complexes as antibacterial agents 10.1016/j.jinorgbio.2015.01.007
Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development 10.1128/mBio.01289-15
Mycobacterium tuberculosis Complex Exhibits Lineage-Specific Variations Affecting Protein Ductility and Epitope Recognition. 10.1093/gbe/evw279
Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis 10.1038/ncomms16085
Breaking Transmission with Vaccines: The Case of Tuberculosis. 10.1128/microbiolspec.MTBP-0001-2016
MTBVAC from discovery to clinical trials in tuberculosis-endemic countries 10.1080/14760584.2017.1324303
MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic 10.3389/fimmu.2017.01803
New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages 10.1371/journal.pgen.1007282
Vaccination against tuberculosis. 10.1016/j.eimc.2018.02.006
Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate 10.1021/acsinfecdis.9b00008
A new live tuberculosis vaccine based on phoP inactivation. 10.1016/s0873-2159(15)30092-1
MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice. 10.1016/j.omtm.2019.01.014
Editorial: Update on the Immune Mechanisms Against Respiratory Pathogens. 10.3389/fimmu.2019.01730
Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial. 10.1016/s2213-2600(19)30251-6
Update on TB Vaccine Pipeline 10.3390/app10072632
Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential 10.1016/j.ebiom.2020.102761
Dynamics of Salmonella small RNA expression in non-growing bacteria located inside eukaryotic cells 10.4161/rna.19317
Identification of three novel antisense RNAs in the fur locus from unicellular cyanobacteria 10.1099/mic.0.048231-0
High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100
Extended safety studies of the attenuated live tuberculosis vaccine SO2 based on phoP mutant 10.1016/j.vaccine.2009.02.060
A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra 10.1128/JB.01465-07
Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials 10.1517/14712598.8.2.201
PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence 10.1371/journal.pone.0003496
The Mycobacterium tuberculosis phoPR Operon Is Positively Autoregulated in the Virulent Strain H37Rv 10.1128/JB.00712-08
The virulence-associated twocomponent PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis 10.1074/jbc.C500388200
Microfluidic devices for studying bacterial taxis, drug testing and biofilm formation 10.1111/1751-7915.13775
MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG 10.1016/j.vaccine.2021.06.049
Engineering a new vaccine platform for heterologous antigen delivery in live-attenuated Mycobacterium tuberculosis 10.1016/j.csbj.2021.07.035
Auguste Genovesio
Genovesio Auguste
ORCID: 0000-0003-1877-5595
An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z β as an Essential Regulator of Spindle Orientation. 10.1016/j.cub.2017.06.055
Smooth 2D manifold extraction from 3D image stack. 10.1038/ncomms15554
Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface. 10.1038/celldisc.2017.5
Detection and tracking of overlapping cell nuclei for large scale mitosis analyses. 10.1186/s12859-016-1030-9
High-throughput in vivo genotoxicity testing: an automated readout system for the somatic mutation and recombination test (SMART). 10.1371/journal.pone.0121287
Increasing the Content of High-Content Screening: An Overview. 10.1177/1087057114528537
Dimerization, oligomerization, and aggregation of human amyotrophic lateral sclerosis copper/zinc superoxide dismutase 1 protein mutant forms in live cells. 10.1074/jbc.m113.542613
Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment. 10.1177/1087057113503553
Development of a multiplex phenotypic cell-based high throughput screening assay to identify novel hepatitis C virus antivirals. 10.1016/j.antiviral.2013.04.020
Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum. 10.1371/journal.pone.0055539
An image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytes. 10.1371/journal.pone.0041765
An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages. 10.1371/journal.pntd.0001671
A novel specific edge effect correction method for RNA interference screenings. 10.1093/bioinformatics/btr648
A high-content subtractive screen for selecting small molecules affecting internalization of GPCRs. 10.1177/1087057111427347
Quantification of protein interaction in living cells by two-photon spectral imaging with fluorescent protein fluorescence resonance energy transfer pair devoid of acceptor bleed-through. 10.1002/cyto.a.21150
Automated genome-wide visual profiling of cellular proteins involved in HIV infection. 10.1177/1087057111415521
Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection. 10.1371/journal.pone.0019733
High content cellular microarray for automated drug target deconvolution. 10.1186/1753-6561-5-s1-p76
Development of a cell-based high throughput assay system and IN-house image analysis software for screening of active compounds against dengue virus. 10.1186/1753-6561-5-s1-p46
A high-throughput cell-based assay to screen for drugs affecting PfEMP1 transport to RBC surface. 10.1186/1753-6561-5-s1-p15
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. 10.1371/journal.ppat.1001100
Contextual automated 3D analysis of subcellular organelles adapted to high-content screening. 10.1177/1087057110374993
Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds. 10.1371/journal.pntd.0000675
A modified fluorescence in situ hybridization protocol for Plasmodium falciparum greatly improves nuclear architecture conservation. 10.1016/j.molbiopara.2010.04.006
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. 10.1371/journal.ppat.1000645
In vivo colocalisation of oskar mRNA and trans-acting proteins revealed by quantitative imaging of the Drosophila oocyte. 10.1371/journal.pone.0006241
Automated high-throughput siRNA transfection in raw 264.7 macrophages: a case study for optimization procedure. 10.1177/1087057108328762
Neuron branch detection and description using random walk. 10.1109/iembs.2009.5334083
A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening. 10.1002/cyto.a.20627
Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle. 10.1371/journal.pone.0002313
Three-dimensional point spread function model for line-scanning confocal microscope with high-aperture objective. 10.1111/j.1365-2818.2007.01844.x
High-content classification of nucleocytoplasmic import or export inhibitors. 10.1177/1087057107301319
Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes. 10.1038/nmeth928
Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood-brain barrier. 10.1084/jem.20060482
SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope. 10.1038/nature04752
Multiple particle tracking in 3-D+t microscopy: method and application to the tracking of endocytosed quantum dots. 10.1109/tip.2006.872323
Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. 10.1083/jcb.200505159
Automated Confocal Microscope Bias Correction 10.1063/1.2361251
Active vector graph for regularized tesselation 10.1109/icip.2009.5414154
IM.Grid, a Grid computing approach for Image Mining of High Throughput-High Content Screening 10.1109/grid.2008.4662818
SUPPORT VECTOR MACHINES FOR AUTOMATIC DETECTION OF TUBERCULOSIS BACTERIA IN CONFOCAL MICROSCOPY IMAGES 10.1109/isbi.2007.356794
A New Color Representation for Intensity Independent Pixel Classification in Confocal Microscopy Images 10.1007/978-3-540-74607-2_54
3D Mumford-Shah Based Active Mesh 10.1007/11892755_21
Tracking fluroescent spots in biological video microscopy 10.1117/12.478040
Automated Identification and Analysis of Visual Micro-experiments on Cellular Microarray 10.1007/978-3-642-25547-2_3
3D Automated Nuclear Morphometric Analysis Using Active Meshes 10.1007/978-3-540-75286-8_34
A method for discontinuous neurite reconstruction based on diffusion tensor, Hessian eigenvector, and diffused gradient vector fields 10.1109/icip.2011.6115702
Cerebral microcirculation shear stress levels determineNeisseria meningitidisattachment sites along the blood–brain barrier 10.1083/jcb1744oia7
mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis 10.1242/jcs.201640
Biased Image Correction Based on Empirical Mode Decomposition 10.1109/icip.2007.4379009
Inhomogeneous deconvolution in a biological images context 10.1109/isbi.2008.4541103
BIAS FREE FEATURES DETECTION FOR HIGH CONTENT SCREENING 10.1109/isbi.2007.356940
Split and merge data association filter for dense multi-target tracking 10.1109/icpr.2004.1333863
Interacting multiple model based method to track moving fluorescent biological spots 10.1109/isbi.2004.1398769
3D spatial drift correction using Kalman filtering for fluorescence based imaging 10.1109/isbi.2009.5193253
Calibrated mitotic oscillator drives motile ciliogenesis 10.1126/science.aan8311
Monitored eCLIP: high accuracy mapping of RNA-protein interactions. 10.1093/nar/gky858
DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis. 10.7554/eLife.37892
Active fluctuations modulate gene expression in mouse oocytes 10.1101/347310
Ependymal cilia beating induces an actin network to protect centrioles against shear stress. 10.1038/s41467-018-04676-w
High-throughput optical mapping of replicating DNA 10.1101/239251
Compound Functional Prediction Using Multiple Unrelated Morphological Profiling Assays. 10.1177/2472630317740831
mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. 10.1242/dev.138271
ALFA: annotation landscape for aligned reads 10.1186/s12864-019-5624-2
Coordination of transcriptional and translational regulations in human epithelial cells infected by Listeria monocytogenes 10.1101/775148
PySpacell: A Python Package for Spatial Analysis of Cell Images 10.1002/cyto.a.23955
In vivo large-scale analysis of Drosophila neuronal calcium traces by automated tracking of single somata 10.1038/s41598-020-64060-x
Coordination of transcriptional and translational regulations in human epithelial cells infected by Listeria monocytogenes 10.1080/15476286.2020.1777380
Unraveling spatial cellular pattern by computational tissue shuffling 10.1038/s42003-020-01323-3
Genome wide natural variation of H3K27me3 selectively marks genes predicted to be important for cell differentiation in Phaeodactylum tricornutum 10.1101/2019.12.26.888800
Genome wide natural variation of H3K27me3 selectively marks genes predicted to be important for cell differentiation in Phaeodactylum tricornutum 10.1111/nph.17129
Gerald Larrouy-Maumus
Larrouy-Maumus Gerald
ORCID: 0000-0001-6614-8698
The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction 10.1111/j.1462-5822.2007.01097.x
AftD, a novel essential arabinofuranosyltransferase from mycobacteria 10.1093/glycob/cwp116
High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100
Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan 10.1099/mic.0.037507-0
Biosynthetic Origin of the Galactosamine Substituent of Arabinogalactan in Mycobacterium tuberculosis 10.1074/jbc.M110.188110
Deciphering sulfoglycolipids of Mycobacterium tuberculosis 10.1194/jlr.M013482
Lipoteichoic Acid in Streptomyces hygroscopicus: Structural Model and Immunomodulatory Activities 10.1371/journal.pone.0026316
Lipoglycans Contribute to Innate Immune Detection of Mycobacteria 10.1371/journal.pone.0028476
Mechanism of Feedback Allosteric Inhibition of ATP Phosphoribosyltransferase 10.1021/bi300808b
A Small Multidrug Resistance-like Transporter Involved in the Arabinosylation of Arabinogalactan and Lipoarabinomannan in Mycobacteria 10.1074/jbc.M112.400986
Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition 10.1016/j.tube.2012.11.008
Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis 10.1073/pnas.1221597110
Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate 10.1038/NCHEMBIO.1355
Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection 10.1371/journal.ppat.1003928
Biosynthesis and Translocation of Unsulfated Acyltrehaloses in Mycobacterium tuberculosis 10.1074/jbc.M114.581199
Lipids as biomarkers of cancer and bacterial infections 10.2174/0929867325666180904120029
Cholesterol acquisition by Mycobacterium tuberculosis 10.1080/21505594.2015.1053688
Chemical Mechanism of Glycerol 3-Phosphate Phosphatase: pH-Dependent Changes in the Rate-Limiting Step 10.1021/bi400856y
The immunomodulatory lipoglycans, lipoarabinomannan and lipomannan, are exposed at the mycobacterial cell surface 10.1016/j.tube.2008.04.002
Mycobacterial envelope lipids fingerprint from direct MALDI-TOF MS analysis of intact bacilli 10.1016/j.tube.2014.11.001
Initiation of Methylglucose Lipopolysaccharide Biosynthesis in Mycobacteria 10.1371/journal.pone.0005447
Rapid detection of colistin resistance in Acinetobacter baumannii using MALDI-TOF-based lipidomics on intact bacteria 10.1038/s41598-018-35041-y
Erratum: Corrigendum: Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate 10.1038/nchembio0214-164a
The presence of a galactosamine substituent on the arabinogalactan of Mycobacterium tuberculosis abrogates full maturation of human peripheral blood monocyte-derived dendritic cells and increases secretion of IL-10 10.1016/j.tube.2015.04.002
Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection 10.1038/s41467-018-04472-6
Crystal structure of glycerol phosphate phosphatase Rv1692 from Mycobacterium tuberculosis in complex with calcium 10.2210/pdb4i9f/pdb
Crystal structure of glycerol phosphate phosphatase Rv1692 from Mycobacterium tuberculosis in complex with magnesium 10.2210/pdb4i9g/pdb
Crystal structure of TacT3 (tRNA acetylating toxin) from Salmonella 10.2210/pdb6g96/pdb
Metabolomic strategies for the identification of new enzyme functions and metabolic pathways 10.15252/embr.201338283
A glycomic approach reveals a new mycobacterial polysaccharide 10.1093/glycob/cwv061
Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis 10.1021/acs.jmedchem.7b00726
Intact Cell Lipidomics Reveal Changes to the Ratio of Cardiolipins to Phosphatidylinositols in Response to Kanamycin in HeLa and Primary Cells 10.1021/acs.chemrestox.8b00038
Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane 10.1101/479618
Metabolomics reveals that the cAMP receptor protein regulates nitrogen and peptidoglycan synthesis in Mycobacterium tuberculosis 10.1039/D0RA05153E
Rapid glycosyl‐inositol‐phospho‐ceramide fingerprint from filamentous fungal pathogens using the MALDI Biotyper Sirius system 10.1002/rcm.8904
Modulation of the cAMP levels with a conserved actinobacteria phosphodiesterase enzyme reduces antimicrobial tolerance in mycobacteria 10.1101/2020.08.26.267864
Early detection of metabolic changes in drug-induced steatosis using metabolomics approaches 10.1039/D0RA06577C
Bacillus subtilis YngB contributes to wall teichoic acid glucosylation and glycolipid formation during anaerobic growth 10.1101/2020.11.30.405621
Metabolomics in infectious diseases and drug discovery 10.1039/D1MO00017A
Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis 10.15252/msb.202110280
Colistin resistance in Escherichia coli confers protection of the cytoplasmic but not outer membrane from the polymyxin antibiotic 10.1101/2021.07.21.453182
Roland Brosch
Brosch Roland
ORCID: 0000-0003-2587-3863
Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity. 10.1016/j.chom.2015.05.017
Insights on the emergence of Mycobacterium tuberculosis from the analysis of Mycobacterium kansasii 10.1093/gbe/evv035
Mycobacterial Pathogenomics and Evolution. 10.1128/microbiolspec.MGM2-0025-2013
Release of mycobacterial antigens 10.1111/imr.12251
Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice 10.1128/IAI.02032-14
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083
Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations 10.1038/srep15443
ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection 10.1016/j.tube.2015.02.019
Developing whole mycobacteria cell vaccines for tuberculosis: Workshop proceedings, Max Planck Institute for Infection Biology, Berlin, Germany, July 9, 2014 10.1016/j.vaccine.2015.03.056
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650
Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans | Les bacilles de la tuberculose bovine - Une évolution aux dépens de la transmissibilité chez l'homme 10.1051/medsci/20153102003
Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection 10.1371/journal.ppat.1003928
Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development 10.2217/fmb.14.70
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator 10.1073/pnas.1406693111
Bacillus calmette-guérin strain differences have an impact on clinical outcome in bladder cancer immunotherapy 10.1016/j.eururo.2014.02.061
A Specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies whiB6 as a novel ESX-1 component 10.1128/IAI.01824-14
A glimpse into the past and predictions for the future: The molecular evolution of the tuberculosis agent 10.1111/mmi.12720
TBCAP; Tuberculosis annotation project 10.1016/j.tube.2012.11.013
Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus 10.1111/mmi.12387
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis 10.1038/ng.2517
ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis 10.1111/cmi.12169
Characterization of Mycobacterium orygis 10.3201/eid1903.121005
The ESX-5 Associated eccB5-eccC5 Locus Is Essential for Mycobacterium tuberculosis Viability 10.1371/journal.pone.0052059
Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion-encoded PE-PPE proteins predicts vaccine potential 10.1016/j.chom.2012.03.003
Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death 10.1371/journal.ppat.1002507
Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh 10.1371/journal.pone.0040545
Molecular epidemiology of tuberculosis in rural Matlab, Bangladesh 10.5588/ijtld.11.0426
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria 10.1111/j.1462-5822.2012.01799.x
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells 10.4161/auto.20881
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation 10.1111/j.1365-2958.2012.08001.x
Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies 10.3201/eid1804.110888
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis 10.1002/eji.201141548
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways 10.1074/jbc.M111.223610
Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants 10.1111/j.1462-5822.2010.01565.x
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG 1on virulence of Mycobacterium tuberculosis 10.1093/infdis/jiq089
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237 10.1016/j.tube.2010.12.007
Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring 10.1016/j.ejmech.2010.09.048
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling 10.1371/journal.ppat.1001100
Entrapment of intracytosolic bacteria by septin cage-like structures 10.1016/j.chom.2010.10.009
Systematic genetic nomenclature for type VII secretion systems 10.1371/journal.ppat.1000507
Pathogenomics of mycobacteria 10.1159/000235772
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Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran