Systematic Genetic Nomenclature for Type VII Secretion Systems
Bitter, Wilbert Houben, Edith N. G. Bottai, Daria Brodin, Priscille Brown, Eric J. Cox, Jeffery S. Derbyshire, Keith Fortune, Sarah M. Gao, Lian-Yong Liu, Jun van Pittius, Nicolaas C. Gey Pym, Alexander S. Rubin, Eric J. Sherman, David R. Cole, Stewart T. Brosch, Roland
PLoS pathogens, 2009-10
https://doi.org/10.1371/journal.ppat.1000507
Edith Houben
Houben Edith / E.N.G. Houben
ORCID: 0000-0002-8805-2002
Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector 10.1111/cmi.12221
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer 10.1111/mmi.12770
Take five - Type VII secretion systems of Mycobacteria 10.1016/j.bbamcr.2013.11.003
Differential Detergent Extraction of Mycobacterium marinum Cell Envelope Proteins Identifies an Extensively Modified Threonine-Rich Outer Membrane Protein with Channel Activity 10.1128/jb.02236-12
Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis 10.1016/j.jsb.2013.09.022
Composition of the type VII secretion system membrane complex 10.1111/j.1365-2958.2012.08206.x
Specific Chaperones for the Type VII Protein Secretion Pathway 10.1074/jbc.M112.397596
Unexpected Link between Lipooligosaccharide Biosynthesis and Surface Protein Release in Mycobacterium marinum 10.1074/jbc.M111.336461
Direct Visualization by Cryo-EM of the Mycobacterial Capsular Layer: A Labile Structure Containing ESX-1-Secreted Proteins 10.1371/journal.ppat.1000794
Differential expression of a virulence factor in pathogenic and non-pathogenic mycobacteria 10.1111/j.1365-2958.2009.06612.x
Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507
Type VII secretion in mycobacteria: classification in line with cell envelope structure 10.1016/j.tim.2009.05.007
Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins 10.1016/j.febslet.2008.02.082
Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5 10.1126/science.1133515
Interaction of pathogenic mycobacteria with the host immune system 10.1016/j.mib.2005.12.014
Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle 10.1074/jbc.M600638200
Biogenesis of inner membrane proteins in Escherichia coli 10.1146/annurev.micro.59.030804.121246
Early encounters of a nascent membrane protein: specificity and timing of contacts inside and outside the ribosome 10.1083/jcb.200503035
Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG 10.1128/jb.187.16.5852-5856.2005
Signal peptide hydrophobicity is critical for early stages in protein export by Bacillus subtilis 10.1111/j.1742-4658.2005.04777.x
The two membrane segments of leader peptidase partition one by one into the lipid bilayer via a Sec/YidC interface 10.1038/sj.embor.7400261
Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome 10.1083/jcb.200302130
Versatility of inner membrane protein biogenesis in Escherichia coli 10.1046/j.1365-2958.2003.03346.x
YidC and SecY mediate membrane insertion of a type I transmembrane domain 10.1074/jbc.M205556200
Nascent Lep inserts into the Escherichia coli inner membrane in the vicinity of YidC, SecY and SecA 10.1016/s0014-5793(00)01735-x
Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein 10.1046/j.1365-2958.1999.01563.x
Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria 10.1371/journal.pgen.1005190
Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes 10.1128/mBio.01471-16
Insertion of leader peptidase into the thylakoid membrane during synthesis in a chloroplast translation system 10.1105/tpc.11.8.1553
Identification of a substrate domain that determines system specificity in mycobacterial type VII secretion systems 10.1038/srep42704
Targeting and translocation of the two lipoproteins in Escherichia coli via the SRP/Sec/YidC pathway. 10.1074/jbc.M403229200
Reconstitution of SecYEG-dependent membrane protein insertion: nacent FtsQ interacts with YidC in a SecYEG-dependent manner. 10.1093/embo-reports/kve106
Type VII secretion: a highly versatile secretion system. 10.1128/microbiolspec.VMBF-0011-2015
Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis 10.1038/nmicrobiol.2017.47
Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis 10.1038/s41564-017-0090-6
EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF 10.1371/journal.ppat.1007247
Bacterial secretion chaperones 10.1093/femsle/fny197
Protease and transmembrane domain of the type VII secretion mycosin protease determine system-specific functioning in mycobacteria 10.1074/jbc.RA118.007090
Protein export into and across the atypical diderm cell envelope of mycobacteria 10.1128/microbiolspec.GPP3-0043-2018
Species-specific secretion of ESX-5 type VII substrates is determined by the linker 2 of EccC5 10.1111/mmi.14496
Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system 10.1074/jbc.RA119.011682
A Chimeric EccB-MycP Fusion Protein is Functional and a Stable Component of the ESX-5 Type VII Secretion System Membrane Complex 10.1016/j.jmb.2019.12.040
Structure and Function of the Mycobacterial Type VII Secretion Systems 10.1146/annurev-micro-012420-081657
Structure and dynamics of a mycobacterial type VII secretion system 10.1038/s41586-021-03517-z
Nicolaas Gey van Pittius
Gey van Pittius Nicolaas / Nicolaas C Gey van Pittius
ORCID: 0000-0002-8807-4105
Iron acquisition strategies in mycobacteria 10.1016/j.tube.2015.01.004
Assessing the progress of Mycobacterium tuberculosis H37Rv structural genomics 10.1016/j.tube.2014.12.005
Phage-based detection of bacterial pathogens 10.1039/c4an00208c
Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosis 10.1093/jac/dkt364
Moxifloxacin retains antimycobacterial activity in the presence of gyra mutations 10.1128/AAC.02583-13
Genetic profile of mycobacterium tuberculosis and treatment outcomes in human pulmonary tuberculosis in Tanzania 10.4314/thrb.v16i2.1
The complex architecture of mycobacterial promoters 10.1016/j.tube.2012.08.003
Spectrum of non-tuberculous mycobacteria identified using standard biochemical testing vs. 16S sequencing 10.5588/ijtld.12.0425
Programmatically Selected Multidrug-Resistant Strains Drive the Emergence of Extensively Drug-Resistant Tuberculosis in South Africa 10.1371/journal.pone.0070919
Prevalence and distribution of non-tuberculous mycobacteria (NTM) in cattle, African buffaloes (syncerus caffer) and their environments in South Africa 10.1111/tbed.12133
Population Structure of Mixed Mycobacterium tuberculosis Infection Is Strain Genotype and Culture Medium Dependent 10.1371/journal.pone.0070178
Novel cause of tuberculosis in meerkats, South Africa 10.3201/eid1912.130268
Mycobacteria and disease in Southern Africa 10.1111/tbed.12159
Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa 10.3201/eid1903.120246
Effect of household and community interventions on the burden of tuberculosis in southern Africa: The ZAMSTAR community-randomised trial 10.1016/S0140-6736(13)61131-9
A metabolomics approach exploring the function of the ESX-3 type VII secretion system of M. smegmatis 10.1007/s11306-012-0481-x
The diagnostic performance of the GenoType MTBDRplus version 2 line probe assay is equivalent to that of the Xpert MTB/RIF assay 10.1128/JCM.01958-12
Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa 10.1128/JCM.05832-11
Mycobacterium tuberculosis population structure determines the outcome of genetics-based second-line drug resistance testing 10.1128/AAC.05905-11
Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in mycobacterium tuberculosis 10.1089/mdr.2011.0063
Infection of African buffalo (Syncerus caffer) by oryx bacillus, a rare member of the antelope clade of the Mycobacterium tuberculosis complex 10.7589/2010-07-178
Independent large scale duplications in multiple M. Tuberculosis lineages overlapping the same genomic region 10.1371/journal.pone.0026038
GenoType MTBDRs/ line probe assay shortens time to diagnosis of extensively drug-resistant tuberculosis in a high-throughput diagnostic laboratory 10.1164/rccm.201205-0960OC
Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa 10.1016/j.meegid.2011.07.019
Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting 10.1016/j.rvsc.2011.03.026
Comparative analysis of mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints 10.1371/journal.pone.0030593
Characterization of Mycobacterium orygis /10.3201/eid1810.120569
Tuberculosis recurrence: Exogenous or endogenous? 10.1159/000324616
Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux 10.1164/rccm.201011-1924OC
Mycobacterium tuberculosis Beijing genotype: A template for success 10.1016/j.tube.2011.07.005
Modification of the QuantiFERON-TB Gold (In-Tube) assay for the diagnosis of Mycobacterium bovis infection in African buffaloes (Syncerus caffer) 10.1016/j.vetimm.2011.04.006
Mixed infections of Corynebacterium pseudotuberculosis and non-tuberculous mycobacteria in South African antelopes presenting with tuberculosis-like lesions 10.1016/j.vetmic.2010.07.017
Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent (Journal of Clinical Microbiology (2007) 45, 7, (2263-2266)) 10.1128/JCM.00660-11
Authors' reply 10.1128/JCM.02089-09
Acquisition, transmission and amplification of drug-resistant tuberculosis 10.1159/000324624
The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa 10.1186/1471-2164-11-670
Novel mycobacterium tuberculosis complex pathogen, M. Mungi 10.3201/eid1608.100314
Mycobacterium tuberculosis strains with the Beijing genotype demonstrate variability in virulence associated with transmission 10.1016/j.tube.2010.08.004
Evaluation of the Capilia TB assay for culture confirmation of Mycobacterium tuberculosis infections in Zambia and South Africa 10.1128/JCM.01688-09
Detection of Mycobacterium kansasii infection in a rhesus macaque (Macaca mulatta) using a modified QuantiFERON-TB Gold assay 10.1016/j.vetimm.2010.03.020
Zoonotic tuberculosis and brucellosis in Africa: Neglected zoonoses or minor public-health issues? The outcomes of a multi-disciplinary workshop 10.1179/136485909X451771
The clinical relevance of Mycobacterial pharmacogenetics 10.1016/j.tube.2009.03.001
Systematic genetic nomenclature for type VII secretion systems 10.1371/journal.ppat.1000507
PPE and PE-PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5 10.1111/j.1365-2958.2009.06783.x
Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes 10.1016/j.tube.2009.08.001
Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region 10.1186/1471-2148-9-237
A balancing act: Efflux/influx in mycobacterial drug resistance 10.1128/AAC.01577-08
Pulmonary infection due to the dassie bacillus (Mycobacterium tuberculosis complex sp.) in a free-living dassie (rock hyrax-Procavia capensis) from South Africa 10.1016/j.tube.2007.08.012
Pulmonary infection due to Mycobacterium goodii in a spotted hyena (Crocuta crocuta) from South Africa 10.7589/0090-3558-44.1.151
Insertion element IS6110-based restriction fragment length polymorphism genotyping of mycobacterium tuberculosis 10.1007/978-1-59745-207-6_24
Frequent homologous recombination events in Mycobacterium tuberculosis PE/PPE multigene families: Potential role in antigenic variability 10.1128/JB.00827-08
Fluorometric assay for testing rifampin susceptibility of Mycobacterium tuberculosis complex 10.1128/JCM.02343-07
Discordance between mycobacterial interspersed repetitive-unit-variable- number tandem-repeat typing and IS6110 restriction fragment length polymorphism genotyping for analysis of Mycobacterium tuberculosis Beijing strains in a setting of high incidence of tuberculosis 10.1128/JCM.00770-08
Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-γ ELISPOT tests following a tuberculosis outbreak 10.1186/1471-2180-8-27
Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family 10.1128/JCM.02231-07
Type VII secretion - Mycobacteria show the way 10.1038/nrmicro1773
The role of IS6110 in the evolution of Mycobacterium tuberculosis 10.1016/j.tube.2007.05.010
Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent 10.1128/JCM.02354-06
Bovine tuberculosis in African buffaloes: Observations regarding Mycobacterium bovis shedding into water and exposure to environmental mycobacteria 10.1186/1746-6148-3-23
Authors' reply [4] 10.1128/JCM.01396-07
Safe Mycobacterium tuberculosis DNA extraction method that does not compromise integrity 10.1128/JCM.44.1.254-256.2006
Insights into the evolutionary history of tubercle bacilli as disclosed by genetic rearrangements within a PE_PGRS duplicated gene pair 10.1186/1471-2148-6-107
Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions 10.1186/1471-2148-6-95
Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patterns 10.1164/rccm.200503-449OC
Mycosin-1, a subtilisin-like serine protease of Mycobacteriumtuberculosis,is cell wall-associated and expressed during infection ofmacrophages 10.1186/1471-2180-2-30
ESAT-6 and CFP-10: What is the diagnosis? (multiple letters) 10.1128/IAI.70.11.6509-6511.2002
The mycosins of Mycobacterium tuberculosis H37Rv: A family of subtilisin-like serine proteases 10.1016/S0378-1119(00)00277-8
Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: Expanding the mycobacterial phosphoproteome catalog 10.3389/fmicb.2015.00006
Whole genome sequence analysis of Mycobacterium suricattae 10.1016/j.tube.2015.10.001
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages 10.1186/s12864-016-2467-y
The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems 10.1186/s12862-016-0631-2
Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem 10.1016/j.meegid.2017.04.012
Molecular epidemiological interpretation of the epidemic of extensively drug-resistant tuberculosis in South Africa 10.1128/JCM.01414-15
Expression and production of soluble Mycobacterium tuberculosis H37Rv mycosin-3 10.1016/j.bbrep.2016.02.005
Comparative genomics and proteomic analysis of four non-tuberculous Mycobacterium species and Mycobacterium tuberculosis complex: Occurrence of shared immunogenic proteins 10.3389/fmicb.2016.00795
A metabolomics investigation of the function of the ESX-1 gene cluster in mycobacteria 10.1016/j.micpath.2016.10.008
Two promoters in the esx-3 gene cluster of Mycobacterium smegmatis respond inversely to different iron concentrations in vitro 10.1186/s13104-017-2752-0
Clinical Relevance of Nontuberculous Mycobacteria Isolated from Sputum in a Gold Mining Workforce in South Africa: An Observational, Clinical Study 10.1155/2015/959107
Alexander Pym
Pym Alexander
ORCID: 0000-0002-6260-8180
Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis. 10.1016/S0140-6736(14)62002-X
Effective anti-tuberculosis therapy correlates with plasma small RNA. 10.1183/09031936.00221214
Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy. 10.1186/2050-6511-15-61
Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis. 10.1056/NEJMoa1407426
Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility. 10.1128/JCM.02438-14
Multidrug-resistant tuberculosis and culture conversion with bedaquiline. 10.1056/NEJMoa1313865
[In Process Citation]. 10.1016/S0399-077X(14)70062-9
Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX. 10.1016/j.bbrc.2014.04.163
Early versus delayed initiation of highly active antiretroviral therapy for HIV-positive adults with newly diagnosed pulmonary tuberculosis (TB-HAART): a prospective, international, randomised, placebo-controlled trial. 10.1016/S1473-3099(14)70733-9
High rates of potentially infectious tuberculosis and multidrug-resistant tuberculosis (MDR-TB) among hospital inpatients in KwaZulu Natal, South Africa indicate risk of nosocomial transmission. 10.1371/journal.pone.0090868
Randomised pharmacokinetic trial of rifabutin with lopinavir/ritonavir-antiretroviral therapy in patients with HIV-associated tuberculosis in Vietnam. 10.1371/journal.pone.0084866
Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study. 10.1016/S2213-2600(13)70231-5
High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria. 10.1371/journal.pone.0077844
Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial. 10.1016/S0140-6736(13)62073-5
Consensus standards for introductory e-learning courses in human participants research ethics. 10.1136/medethics-2013-101572
EDCTP regional networks of excellence: initial merits for planned clinical trials in Africa. 10.1186/1471-2458-13-258
Compassionate use of and expanded access to new drugs for drug-resistant tuberculosis. 10.5588/ijtld.12.0017
Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide. 10.1073/pnas.1203636109
Reduced antituberculosis drug concentrations in HIV-infected patients who are men or have low weight: implications for international dosing guidelines. 10.1128/AAC.05526-11
Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance. 10.1128/AAC.06126-11
International spread of MDR TB from Tugela Ferry, South Africa. 10.3201/eid1711.110291
Drug-Resistant tuberculosis, KwaZulu-Natal, South Africa, 2001-2007. 10.3201/eid1710.100952
Systematic genetic nomenclature for type VII secretion systems. 10.1371/journal.ppat.1000507
The diarylquinoline TMC207 for multidrug-resistant tuberculosis. 10.1056/NEJMoa0808427
Are survey-based estimates of the burden of drug resistant TB too low? Insight from a simulation study. 10.1371/journal.pone.0002363
Challenges in estimating the total burden of drug-resistant tuberculosis. 10.1164/rccm.200801-175PP
Safety of nevirapine in pregnancy. 10.1111/j.1468-1293.2007.00433.x
Evaluation of new antituberculosis drugs in mouse models. 10.1128/AAC.01246-06
Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis. 10.1371/journal.ppat.0020061
Genomic deletions classify the Beijing/W strains as a distinct genetic lineage of Mycobacterium tuberculosis. 10.1128/JCM.43.7.3185-3191.2005
Does resistance to pyrazinamide accurately indicate the presence of Mycobacterium bovis? 10.1128/JCM.43.7.3530-3532.2005
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. 10.1016/j.tube.2004.09.009
High-throughput method for detecting genomic-deletion polymorphisms. 10.1128/JCM.42.7.2913-2918.2004
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. 10.1038/nm859
Proteome analysis of the plasma membrane of Mycobacterium tuberculosis. 10.1002/cfg.211
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. 10.1046/j.1365-2958.2002.03237.x
Effect of katG mutations on the virulence of Mycobacterium tuberculosis and the implication for transmission in humans. 10.1128/IAI.70.9.4955-4960.2002
A new evolutionary scenario for the Mycobacterium tuberculosis complex. 10.1073/pnas.052548299
Inactivation of the Mycobacterium tuberculosis Nramp orthologue (mntH) does not affect virulence in a mouse model of tuberculosis. 10.1111/j.1574-6968.2002.tb11032.x
The evolution of mycobacterial pathogenicity: clues from comparative genomics. 10.1016/S0966-842X(01)02131-X
Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. 10.1046/j.1365-2958.2001.02427.x
Tools for the population genomics of the tubercle bacilli. 10.1101/gr.169200
Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur. 10.1002/1097-0061(20000630)17:2<111::AID-YEA17>3.0.CO;2-G
The rabbit study: ritonavir and saquinavir in combination in saquinavir-experienced and previously untreated patients. 10.1089/088922299310278
The in vivo effects of combination antiretroviral drug therapy on peripheral blood CD34+ cell colony-forming units from HIV type 1-infected patients. 10.1089/088922299311079
Post DOTS, post genomics: the next century of tuberculosis control. 10.1016/S0140-6736(99)02118-2
Disease progression and survival in HIV-1-infected Africans in London. 10.1097/00002030-199810000-00013
Disease progression and survival following specific AIDS-defining conditions: a retrospective cohort study of 2048 HIV-infected persons in London. 10.1097/00002030-199809000-00006
Pasteurella multocida abcess in an African patient with human immunodeficiency virus infection. 10.1111/j.1469-0691.1997.tb00484.x
Vancouver: optimism, but at a cost. 10.1258/0956462961918257
Reasons for increased incidence of tuberculosis. Audit suggests that undernotification is common. 10.1136/bmj.311.7004.570a
Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics. 10.1016/j.ebiom.2016.05.041
Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance. 10.1038/ng.3548
Assessing Local Risk of Rifampicin-Resistant Tuberculosis in KwaZulu-Natal, South Africa Using Lot Quality Assurance Sampling. 10.1371/journal.pone.0153143
Population pharmacokinetic drug-drug interaction pooled analysis of existing data for rifabutin and HIV PIs. 10.1093/jac/dkv470
Assessing the utility of Xpert(®) MTB/RIF as a screening tool for patients admitted to medical wards in South Africa. 10.1038/srep19391
Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis. 10.1183/13993003.00724-2015
Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis. 10.1128/aac.01195-15
Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal. 10.1371/journal.pmed.1001880
Completeness and Reliability of the Republic of South Africa National Tuberculosis (TB) Surveillance System. 10.1186/s12889-015-2117-3
Treatment of drug-resistant tuberculosis with bedaquiline in a high HIV prevalence setting: an interim cohort analysis. 10.5588/ijtld.14.0944
Test characteristics and potential impact of the urine LAM lateral flow assay in HIV-infected outpatients under investigation for TB and able to self-expectorate sputum for diagnostic testing. 10.1186/s12879-015-0967-z
Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study. 10.1186/s12879-015-0964-2
Fatal nosocomial MDR TB identified through routine genetic analysis and whole-genome sequencing. 10.3201/eid2106.141903
Biomarkers for Tuberculosis Based on Secreted, Species-Specific, Bacterial Small Molecules. 10.1093/infdis/jiv312
Impact of tuberculosis treatment and antiretroviral therapy on serial RD-1-specific quantitative T-cell readouts (QuantiFERON-TB Gold In-Tube), and relationship to treatment-related outcomes and bacterial burden. 10.1016/j.ijid.2015.05.006
A Novel Reporter Phage To Detect Tuberculosis and Rifampin Resistance in a High-HIV-Burden Population. 10.1128/jcm.03530-14
Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis. 10.1186/s12916-017-0947-9
Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance. 10.1128/aac.01461-17
A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide. 10.1038/s41467-017-00721-2
Clofazimine protects against Mycobacterium tuberculosis dissemination in the central nervous system following aerosol challenge in a murine model. 10.1016/j.ijantimicag.2017.08.020
Isoniazid-monoresistant tuberculosis is associated with poor treatment outcomes in Durban, South Africa. 10.5588/ijtld.16.0843
Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells. 10.7554/elife.22028
Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance. 10.1038/ng.3767
Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum. 10.1128/mbio.01023-16
Priscille Brodin
Brodin Priscille
ORCID: 0000-0003-0991-7344
Email: priscille.brodin@inserm.fr
How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011
Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227 10.3390/toxins9070227.
Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections 10.2217/nnm-2016-0364
Cyclodextrin-based nanocarriers containing a synergic drug combination: a potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030 10.1016/j.ijpharm.2017.05.030.
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z
Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005 10.1016/j.drudis.2017.05.005.
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535
Impact of pe_ pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis 10.3389/fcimb.2017.00137
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129 10.1002/cyto.a.23129.
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5
Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization 10.1016/j.str.2016.07.009
Mycolactone The amazing analgesic mycobacterial toxin 10.1051/medsci/20163202007
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650
High content screening in chemical biology: overview and main challenges 10.1051/medsci/20153102016
High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis 10.1128/aac.03705-14
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438
Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15
Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays 10.1007/978-1-4939-2450-9_24
A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening 10.3791/51114
Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/jm500422b
Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040
Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022
A novel specific edge effect correction method for RNA interference screenings 10.1093/bioinformatics/btr648
Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779
Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u
The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence 10.1371/journal.pone.0047573
Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis 10.1371/journal.pone.0026675
Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200076a
High-content screening in infectious diseases 10.1016/j.cbpa.2011.05.023
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ 10.1099/mic.0.038133-0
High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100
High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery 10.4155/fmc.10.223
Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting 10.1016/j.biomaterials.2009.09.044
Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure 10.1177/1087057108328762
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis 10.1126/science.1171583
High Content Screening Identifies Decaprenyl-Phosphoribose 2 ' Epimerase as a Target for Intracellular Antimycobacterial Inhibitors 10.1371/journal.ppat.1000645
Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507
Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033
Aquatic insects and transmission of Mycobacterium ulcerans 10.1051/medsci/20072367572
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 10.1128/jb.00469-07
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis 10.1371/journal.ppat.0030062
Protection against mycobacterium ulcerans lesion development by exposure to aquatic insect saliva 10.1371/journal.pmed.0040064
Support vector machines for automatic detection of tuberculosis bacteria in confocal microscopy images 10.1109/isbi.2007.356794
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues 10.1016/j.bmc.2006.12.009
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis 10.1128/iai.74.4.2128-2137.2006
Benzofuro 3,2-f 1 benzopyrans: A new class of antitubercular agents 10.1016/j.bmc.2006.03.033
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/iai.74.1.88-98.2006
High frequency of CD4(+) T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection 10.1128/iai.02086-05
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence 10.1128/jb.00631-06
Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis 10.1016/j.tube.2004.09.009
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200
Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics 10.1099/mic.0.27799-0
Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions 10.1016/j.jmb.2005.05.049
Tuberculosis: from genome to vaccine 10.1586/14760584.4.4.541
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6 10.1128/iai.72.4.2170-2176.2004
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468
ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex 10.1099/mic.0.26662-0
CD8(+)-T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family 10.1128/iai.71.12.7173-7177.2003
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/nm859
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant 10.1128/iai.70.10.5568-5578.2002
Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides 10.1021/bi015732y
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x
6-Oxocytidine containing oligonucleotides inhibit the HIV-1 integrase in vitro 10.1081/ncn-100002322
Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase 10.1021/bi000398b
Inhibition of the human immunodeficiency virus type 1 DNA integration by modified oligonucleotides 10.1023/a:1026631910681
Branched oligonucleotide-intercalator conjugate forming a parallel stranded structure inhibits HIV-1 integrase 10.1016/s0014-5793(99)01350-2
Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides 10.1080/07328319908044831
Optimization of alternate-strand triple helix formation at the 5 '-TpA-3 ' and 5 '-ApT-3 ' junctions 10.1093/nar/27.15.3029
A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus 10.1074/jbc.272.25.16010
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371 10.15252/embr.201744371.
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017 10.1016/j.mib.2017.11.017.
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101 10.1016/j.celrep.2017.08.101.
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114 10.1073/pnas.1707840114.
Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry 10.1128/jvi.01982-17
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025
Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation 10.3389/fimmu.2018.00086
Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis 10.1128/aac.00359-18
The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129
A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening 10.1002/cyto.a.20627
Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation 10.1074/mcp.RA119.001316
Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902
Mitochondrial Dynamics and Activity in Legionella-Infected Cells 10.1007/978-1-4939-9048-1_13
Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258
Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication 10.1128/jvi.02009-18
A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J
Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls 10.3390/toxins11090516
Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies. 10.3389/fimmu.2020.569127
Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity. 10.1021/acsinfecdis.9b00277
Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds. 10.1371/journal.pone.0227224
Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis. 10.1016/j.vaccine.2019.11.085
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551
Worms' Antimicrobial Peptides. 10.3390/md17090512
Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. 10.1371/journal.pone.0198226
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570
Cell microbiology interview 10.1111/cmi.13288
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505
Nathalie deboosere
deboosere Nathalie
ORCID: 0000-0002-2873-5485
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 10.1016/j.celrep.2017.08.101
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. 10.3390/toxins9070227
Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. 10.1021/acschembio.7b00091
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. 10.1111/cmi.12619
A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114
Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces. 10.1016/j.fm.2012.04.007
Viral elution and concentration method for detection of influenza A viruses in mud by real-time RT-PCR. 10.1016/j.jviromet.2011.10.013
Comparison of chlorine and peroxyacetic-based disinfectant to inactivate Feline calicivirus, Murine norovirus and Hepatitis A virus on lettuce. 10.1016/j.ijfoodmicro.2011.08.011
Direct detection of highly pathogenic avian influenza A/H5N1 virus from mud specimens. 10.1016/j.jviromet.2011.06.002
Development and validation of a concentration method for the detection of influenza a viruses from large volumes of surface water. 10.1128/aem.02484-10
A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries. 10.1016/j.fm.2010.05.018
Assessment of the removal and inactivation of influenza viruses H5N1 and H1N1 by drinking water treatment. 10.1016/j.watres.2010.01.013
Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables. 10.1016/j.ijfoodmicro.2005.11.007
Modelling effect of physical and chemical parameters on heat inactivation kinetics of hepatitis A virus in a fruit model system. 10.1016/j.ijfoodmicro.2003.10.015
Host-pathogen systems for early drug discovery against tuberculosis. 10.1016/j.mib.2017.11.017
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids. 10.1073/pnas.1707840114
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. 10.1038/s41598-017-11843-4
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages. 10.1016/j.chom.2017.07.020
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-017-05453-3
Host-directed therapies offer novel opportunities for the fight against tuberculosis. 10.1016/j.drudis.2017.05.005
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs. 10.1016/j.ijpharm.2017.05.030
Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis. 10.3389/fcimb.2017.00137
Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections. 10.2217/nnm-2016-0364
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. 10.1126/science.aag1006
How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 10.1007/s00401-016-1652-z
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535
Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization. 10.1016/j.str.2016.07.009
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro. 10.1007/s00705-016-2771-5
[Mycolactone: the amazing analgesic mycobacterial toxin]. 10.1051/medsci/20163202007
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. 10.1039/c5ob02630j
Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action. 10.1128/jvi.01473-15
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system. 10.1016/j.vaccine.2015.03.083
Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo. 10.1371/journal.ppat.1004650
[High content screening in chemical biology: overview and main challenges]. 10.1051/medsci/20153102016
Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays. 10.1007/978-1-4939-2450-9_24
2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1. 10.1021/cb5007163
High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis. 10.1128/aac.03705-14
Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways. 10.1016/j.cell.2014.04.040
Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches. 10.1021/jm500422b
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262
The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence. 10.1371/journal.pone.0047573
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors. 10.1021/jm200825u
A novel specific edge effect correction method for RNA interference screenings. 10.1093/bioinformatics/btr648
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis. 10.1371/journal.pone.0026675
High-content screening in infectious diseases. 10.1016/j.cbpa.2011.05.023
Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors. 10.1021/jm200076a
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. 10.1371/journal.ppat.1001100
High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery. 10.4155/fmc.10.223
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ. 10.1099/mic.0.038133-0
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. 10.1371/journal.ppat.1000645
Systematic genetic nomenclature for type VII secretion systems. 10.1371/journal.ppat.1000507
Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. 10.1016/j.biomaterials.2009.09.044
Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. 10.1126/science.1171583
Automated high-throughput siRNA transfection in raw 264.7 macrophages: a case study for optimization procedure. 10.1177/1087057108328762
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. 10.1371/journal.ppat.0040033
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. 10.1128/jb.00469-07
[Aquatic insects and transmission of Mycobacterium ulcerans]. 10.1051/medsci/20072367572
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis. 10.1371/journal.ppat.0030062
Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva. 10.1371/journal.pmed.0040064
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues. 10.1016/j.bmc.2006.12.009
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence. 10.1128/jb.00631-06
High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection. 10.1128/iai.02086-05
Benzofuro[3,2-f][1]benzopyrans: a new class of antitubercular agents. 10.1016/j.bmc.2006.03.033
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis. 10.1128/iai.74.4.2128-2137.2006
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. 10.1128/iai.74.1.88-98.2006
Tuberculosis: from genome to vaccine. 10.1586/14760584.4.4.541
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity. 10.1074/jbc.m503515200
Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics. 10.1099/mic.0.27799-0
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. 10.1016/j.tube.2004.09.009
ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens. 10.1086/421468
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6. 10.1128/iai.72.4.2170-2176.2004
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex. 10.1099/mic.0.26662-0
CD8+-T-cell responses of Mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family. 10.1128/iai.71.12.7173-7177.2003
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. 10.1038/nm859
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. 10.1046/j.1365-2958.2002.03237.x
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. 10.1128/iai.70.10.5568-5578.2002
Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides. 10.1021/bi015732y
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551
Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483
Wilbert Bitter
Bitter Wilbert
ORCID: 0000-0001-8347-6511
Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507
Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. 10.1371/journal.ppat.1000794
PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5 10.1111/j.1365-2958.2009.06783.x
Characterization of five novel Pseudomonas aeruginosa cell-surface signalling systems 10.1111/j.1365-2958.2007.06061.x
Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. 10.1016/j.molimm.2003.10.003
The heterologous siderophores ferrioxamine B and ferrichrome activate signaling pathways in Pseudomonas aeruginosa 10.1128/JB.188.5.1882-1891.2006
Type VII secretion in mycobacteria: classification in line with cell envelope structure. 10.1016/j.tim.2009.05.007
Zebrafish development and regeneration: new tools for biomedical research 10.1387/ijdb.082615sb
Role of calcium ion and the disulfide bond in the Burkholderia glumae lipase. 10.1016/S1381-1177(03)00047-X
Tubercle bacilli rely on a type VII army for pathogenicity. 10.1016/j.tim.2012.07.001
The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response 10.4049/jimmunol.181.10.7166
Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish 10.1016/j.dci.2007.04.003
Identification of a substrate domain that determines system specificity in mycobacterial type VII secretion systems 10.1038/srep42704
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection 10.1016/j.celrep.2017.02.057
Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity 10.1111/cmi.12175
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria. 10.1111/j.1462-5822.2012.01799.x
Mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence. 10.1128/IAI.72.11.6306-6312.2004
Take five - Type VII secretion systems of Mycobacteria 10.1016/j.bbamcr.2013.11.003
Molecular patchwork: Chromosomal recombination between two Helicobacter pylori strains during natural colonization. 10.1128/IAI.71.5.2907-2910.2003
Do mycobacteria produce endospores? 10.1073/pnas.0911299107
The Prc and RseP proteases control bacterial cell-surface signalling activity. 10.1111/1462-2920.12371
Complete genome sequence of Mycobacterium xenopi type strain RIVM700367 10.1128/JB.00482-12
Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations. 10.1038/srep15443
The Dienes Phenomenon: Competition and Territoriality in Swarming Proteus mirabilis 10.1128/JB.00975-08
iniBAC induction is vitamin B12- and MutAB-dependent in mycobacterium. 10.1074/jbc.M116.724088
Complete Genome Sequence of Mycobacterium fortuitum subsp. fortuitum Type Strain DSM46621 10.1128/JB.01461-12
A general secretion signal for the mycobacterial type VII secretion pathway 10.1073/pnas.1119453109
The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity. 10.1074/jbc.M115.654756
Type VII secretion-mycobacteria show the way. 10.1038/nrmicro1773
Composition of the type VII secretion system membrane complex. 10.1111/j.1365-2958.2012.08206.x
A star with stripes: zebrafish as an infection model. 10.1016/j.tim.2004.08.001
Type VII secretion: a highly versatile secretion system. 10.1128/microbiolspec.VMBF-0011-2015
A Novel Extracytoplasmic Function (ECF) Sigma Factor Regulates Virulence in Pseudomonas aeruginosa 10.1371/journal.ppat.1000572
Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components 10.1016/j.molimm.2009.03.024
SecB-like chaperone controls a toxin-antitoxin stress-responsive system in Mycobacterium tuberculosis 10.1073/pnas.1101189108
Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium 10.1016/j.jinorgbio.2017.12.003
Transmission of Mycobacterium marinum from fish to a very young child 10.1097/INF.0b013e318151415c
Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan 10.1099/mic.0.037507-0
Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector. 10.1111/cmi.12221
Specific Chaperones for the Type VII Protein Secretion Pathway 10.1074/jbc.M112.397596
Towards a new combination therapy for tuberculosis with next generation benzothiazinones 10.1002/emmm.201303575
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG(5) in complex with PE25-PPE41 dimer 10.1111/mmi.12770
Functional Dissection of the PE Domain Responsible for Translocation of PE_PGRS33 across the Mycobacterial Cell Wall 10.1371/journal.pone.0027713
ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish. 10.1111/j.1462-5822.2012.01755.x
Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infections. 10.1046/j.1462-5822.2003.00303.x
Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death. 10.1371/journal.ppat.1002507
Targeting bacterial virulence: the coming out of type VII secretion inhibitors. 10.1016/j.chom.2014.09.010
Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis 10.1038/nmicrobiol.2017.47
Role for Escherichia coli YidD in Membrane Protein Insertion 10.1128/JB.05429-11
Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model 10.1186/s12974-016-0655-y
Secretins of Pseudomonas aeruginosa: large holes in the outer membrane. 10.1007/s00203-003-0541-8
Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) Protein Domains Target LipY Lipases of Pathogenic Mycobacteria to the Cell Surface via the ESX-5 Pathway 10.1074/jbc.M110.204966
Identification of a novel conjugative plasmid in mycobacteria that requires both type IV and type VII secretion. 10.1128/mBio.01744-14
Role of Pseudomonas putida tol-oprL gene products in uptake of solutes through the cytoplasmic membrane. 10.1128/JB.185.16.4707-4716.2003
Complete genome sequence of Mycobacterium vaccae type strain ATCC 25954 10.1128/JB.01462-12
Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component 10.1242/dmm.006676
Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum. 10.1242/dmm.015453
Processing of cell-surface signalling anti-sigma factors prior to signal recognition is aconserved autoproteolytic mechanism that produces two functional domains. 10.1111/1462-2920.12776
Inorganic phosphate limitation modulates capsular polysaccharide composition in Micobacteria. 10.1074/jbc.M116.722454
Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum. 10.1074/jbc.M111.336461
A specific secretion system mediates PPE41 transport in pathogenic mycobacteria 10.1111/j.1365-2958.2006.05409.x
The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction 10.1111/j.1462-5822.2007.01097.x
Genome-wide transposon mutagenesis indicates that Mycobacterium marinum customizes its virulence mechanisms for survival and replication in different hosts. 10.1128/IAI.03050-14
The Ag85B protein of the BCG vaccine facilitates macrophage uptake but is dispensable for protection against aerosol Mycobacterium tuberculosis infection. 10.1016/j.vaccine.2016.03.089
Differential Detergent Extraction of Mycobacterium marinum Cell Envelope Proteins Identifies an Extensively Modified Threonine-Rich Outer Membrane Protein with Channel Activity 10.1128/JB.02236-12
A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection. 10.1038/s41598-017-10944-4
Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis 10.1016/j.jsb.2013.09.022
Fine-mapping the contact sites of the Escherichia coli cell division proteins FtsB and FtsL on the FtsQ protein 10.1074/jbc.M113.485888
Self-cleavage of the Pseudomonas aerugginosa cell-surface signaling anti-sigma factor FoxR occurs through an N-O acyl rearrangement. 10.1074/jbc.M115.643098
Getting across the Cell Envelope: Mycobacterial Protein Secretion 10.1007/82_2012_298
Complete genome sequence of Mycobacterium phlei type strain RIVM601174 10.1128/JB.00485-12
The ESX-5 system of pathogenic mycobacteria is involved in capsule integrity and virulence through its substrate PPE10 10.1371/journal.ppat.1005696
Impact of protein domains on PE_PGRS30 polar localization in Mycobacteria. 10.1371/journal.pone.0112482
Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria. 10.1371/journal.pgen.1005190
Mycosins are required for the stabilization of the ESX-1 and ESX-5 type VII secretion membrane complexes. 10.1128/mBio.01471-16
Mycobacterial Secretion Systems ESX-1 and ESX-5 Play Distinct Roles in Host Cell Death and Inflammasome Activation 10.4049/jimmunol.1101457
Pathogens under stress. 10.1111/1574-6976.12090
The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity 10.1371/journal.ppat.1006876
Sulfur cave (Romania), an extreme environment with microbial mats in a Co2-H2S/O2 gas chemocline dominated by mycobacteria 10.5038/1827-806X.47.2.2164
Environmental Mycobacterium avium subsp. hominissuis have a higher probability to act as a recipient in conjugation than clinical strains 10.1016/j.plasmid.2018.01.003
Accelerating early antituberculosis drug discovery by creating mycobacterial indicator strains that predict mode of action 10.1128/AAC.00083-18
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection 10.1371/journal.ppat.1007139
Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners 10.1007/s00253-018-9299-4
EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF 10.1371/journal.ppat.1007247
Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis 10.1038/s41564-017-0090-6
Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria 10.1021/acschembio.8b00790
Mycobacteria employ two different mechanisms to cross the blood-brain barrier 10.1111/cmi.12858
Protease domain and transmembrane domain of the type VII secretion mycosin protease determine system-specific functioning in mycobacteria 10.1074/jbc.RA118.007090
Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose 10.1371/journal.pgen.1007131
Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator 10.1371/journal.pone.0211003
Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? 10.1007/s00253-019-09697-z
Optimization of secretion and surface localization of heterologous OVA protein in mycobacteria by using LipY as a carrier 11 Medical and Health Sciences 1107 Immunology 10.1186/s12934-019-1093-1
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. 10.1111/j.1365-2958.2012.08001.x
Mutagenesis-Based Characterization and Improvement of a Novel Inclusion Body Tag 10.3389/fbioe.2019.00442
Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease 10.1128/mBio.01951-19
Role of Mycobacterium avium lysate INF-γ, IL-17, and IL-2 ELISPOT assays in diagnosing nontuberculous mycobacteria lymphadenitis in children 10.1007/s10096-019-03506-1
Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system 10.1074/jbc.RA119.011682
A Chimeric EccB-MycP Fusion Protein is Functional and a Stable Component of the ESX-5 Type VII Secretion System Membrane Complex 10.1016/j.jmb.2019.12.040
Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis 10.1016/j.bcp.2020.113938
Structure and Function of the Mycobacterial Type VII Secretion Systems 10.1146/annurev-micro-012420-081657
Species-specific secretion of ESX-5 type VII substrates is determined by the linker 2 of EccC5 10.1111/mmi.14496
Zebrafish embryo model for assessment of drug efficacy on mycobacterial persisters 10.1128/AAC.00801-20
Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9 10.1016/j.tube.2020.101983
Comparative Genomic and Transcriptomic Analyses of Mycobacterium kansasii Subtypes Provide New Insights Into Their Pathogenicity and Taxonomy 10.3389/fcimb.2020.00122
The extracytoplasmic function sigma factor σVreI is active during infection and contributes to phosphate starvation-induced virulence of Pseudomonas aeruginosa 10.1038/s41598-020-60197-x
Mycobacterium tuberculosis toxin cpnt is an esx-5 substrate and requires three type vii secretion systems for intracellular secretion 10.1128/mBio.02983-20
A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline 10.1038/s42003-021-01809-8
Heterologous Expression of ethA and katG in Mycobacterium marinum Enables the Rapid Identification of New Prodrugs Active against Mycobacterium tuberculosis 10.1128/AAC.01445-20
Surface Labeling with Adhesion Protein FimH Improves Binding of Immunotherapeutic Agent Salmonella Ty21a to the Bladder Epithelium 10.3233/BLC-200382
Structure and dynamics of a mycobacterial type VII secretion system 10.1038/s41586-021-03517-z
IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo 10.1128/mSphere.00153-21
PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages 10.3389/fimmu.2021.702359
Eric Rubin
Rubin Eric
ORCID: 0000-0001-5120-962X
Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX 10.1016/j.bbrc.2014.04.163
Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c 10.1073/pnas.1315883111
Troubles with tuberculosis prevention 10.1056/NEJMe1312301
Binding of MgtR, a Salmonella transmembrane regulatory peptide, to MgtC, a Mycobacterium tuberculosis virulence factor: A structural study 10.1016/j.jmb.2013.10.014
Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance 10.1073/pnas.1317580111/-/DCSupplemental
Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis 10.1371/journal.ppat.1003994
Tryptophan biosynthesis protects mycobacteria from CD4 T-Cell-mediated Killing 10.1016/j.cell.2013.10.045
High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria 10.1371/journal.pone.0077844
Erratum: Para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase inMycobacterium tuberculosis (Journal of Biological Chemistry (2013) 288 (23447-23456)) 10.1074/jbc.A113.475798
Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis 10.1038/ng.2747
High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data 10.1093/nar/gkt654
Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis 10.1371/journal.pone.0075245
Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis 10.1074/jbc.M113.475798
Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32 10.1073/pnas.1302114110
Feast or famine: The host-pathogen battle over amino acids 10.1111/cmi.12140
Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries 10.1093/bioinformatics/btt043
Protein Complexes and Proteolytic Activation of the Cell Wall Hydrolase RipA Regulate Septal Resolution in Mycobacteria 10.1371/journal.ppat.1003197
Mycobacterium tuberculosis ESAT-6 exhibits a unique membrane-interacting activity that is not found in its ortholog from non-pathogenic Mycobacterium smegmatis 10.1074/jbc.M112.420869
Detection and treatment of subclinical tuberculosis 10.1016/j.tube.2012.06.004
Bacterial proteolytic complexes as therapeutic targets 10.1038/nrd3846
Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis 10.1371/journal.ppat.1002946
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring 10.1038/emboj.2012.5
Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection 10.1371/journal.ppat.1002511
A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria 10.1126/scisignal.2002525
Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis 10.1073/pnas.1109958109
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 10.1128/AAC.05270-11
Characterization and transcriptome analysis of mycobacterium tuberculosis persisters 10.1128/mBio.00100-11
Latent tuberculosis infection in the United States 10.1056/NEJMcp1005750
Depletion of antibiotic targets has widely varying effects on growth 10.1073/pnas.1018301108
Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase 10.1093/nar/gkq1149
Letting sleeping dos lie: Does dormancy play a role in tuberculosis? 10.1146/annurev.micro.112408.134043
Host transcription in active and latent tuberculosis 10.1186/gb-2010-11-9-135
The Abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis 10.1016/j.tube.2010.08.002
Structural characterization of the mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase 10.1021/bi902097j
Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria 10.1371/journal.ppat.1001020
Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories 10.1128/JB.00166-10
Relics of selection in the mycobacterial genome 10.1038/ng0610-476
Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin 10.1073/pnas.0912952107
Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition 10.1073/pnas.0900589106
Systematic genetic nomenclature for type VII secretion systems 10.1371/journal.ppat.1000507
Phthiocerol dimycocerosate transport is required for resisting interferon-γ-independent immunity 10.1086/605128
HIV-1 replication is differentially regulated by distinct clinical strains of Mycobacterium tuberculosis 10.1371/journal.pone.0006116
The granuloma in tuberculosis - Friend or foe? 10.1056/NEJMcibr0902539
Nitrile-inducible gene expression in mycobacteria 10.1016/j.tube.2008.07.007
Phage transposon mutagenesis 10.1007/978-1-59745-207-6_21
The many roads to essential genes 10.1016/S1472-9792(08)70033-7
Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis 10.1016/j.cbpa.2007.12.005
Bacterial growth and cell division: A mycobacterial perspective 10.1128/MMBR.00028-07
Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein 10.1128/JB.01046-07
ESCRT factors restrict mycobacterial growth 10.1073/pnas.0707206105
A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor 10.1371/journal.ppat.1000001
Mycobacterium tuberculosis Rv2224c modulates innate immune responses 10.1073/pnas.0710601105
Drugs versus bugs: In pursuit of the persistent predator Mycobacterium tuberculosis 10.1038/nrmicro1816
A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis 10.1111/j.1365-2958.2007.05945.x
The Complex Relationship between Mycobacteria and Macrophages: It's Not All Bliss 10.1016/j.chom.2007.06.008
Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis 10.1371/journal.ppat.0030084
A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity 10.1128/IAI.01789-06
The open book of infectious diseases 10.1038/nm0307-279
Characterization of mycobacterial virulence genes through genetic interaction mapping 10.1073/pnas.0603179103
Chemical biology and bacteria: not simply a matter of life or death 10.1016/j.cbpa.2006.06.016
Scaling down: A PCR-based method to efficiently screen for desired knockouts in a high density Mycobacterium tuberculosis picked mutant library 10.1016/j.tube.2006.01.015
Dividing oceans into pools: strategies for the global analysis of bacterial genes 10.1016/j.micinf.2005.11.015
Detecting genetic variability among different Mycobacterium tuberculosis strains using DNA microarrays technology 10.1016/j.tube.2006.01.002
Once upon a time . . . Improved intermittent therapy for tuberculosis - Fact or fable? 10.1164/rccm.2509003
Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates 10.1128/AAC.49.11.4778-4780.2005
A new site-specific integration system for mycobacteria 10.1016/j.tube.2005.08.016
Genome-wide RNAi screen for host factors required for intracellular bacterial infection 10.1126/science.1116008
Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection 10.1126/science.1116006
New genetic approaches shed light on TB virulence 10.1016/j.tim.2005.06.003
Mutually dependent secretion of proteins required for mycobacterial virulence 10.1073/pnas.0504922102
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages 10.1073/pnas.0503272102
Mycobacterium tuberculosis and the host response 10.1084/jem.20050842
Toward a new therapy for tuberculosis 10.1056/NEJMcibr044438
The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria 10.1111/j.1365-2958.2004.04120.x
Genetic requirements for mycobacterial survival during infection 10.1073/pnas.2134250100
Bacterial genomics and vaccine design 10.1586/14760584.2.3.437
Genes required for mycobacterial growth defined by high density mutagenesis 10.1046/j.1365-2958.2003.03425.x
Construction of a mariner-based transposon for epitope-tagging and genomic targeting 10.1016/S0378-1119(02)00856-9
Genomic analyses of microbial virulence 10.1016/S1369-5274(02)00281-3
A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae 10.1073/pnas.012602299
Comprehensive identification of conditionally essential genes in mycobacteria 10.1073/pnas.231275498
A 25-year old woman with fever and abnormal liver function 10.1056/NEJM200107193450308
Hyperactive transposase mutants of the Himar1 mariner transposon 10.1073/pnas.96.20.11428
In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria 10.1073/pnas.96.4.1645
Mobile genetic elements and the evolution of new epidemic strains of Vibrio cholerae 10.1016/S1874-5326(07)80028-7
Systematic identification of essential genes by in vitro mariner mutagenesis 10.1073/pnas.95.15.8927
Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage 10.1046/j.1365-2958.1998.00889.x
Cholera: Molecular basis for emergence and pathogenesis 10.1016/S0928-8244(97)00054-0
A 71-year-old woman with confusion, hemianopia, and an occipital mass 10.1056/NEJM199310283291809
A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis 10.7554/eLife.14590
Global assessment of Mycobacterium avium subspecies hominissuis genetic requirement for growth and virulence 10.1101/568477
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair 10.1126/science.aay0934
The mycobacterial cell envelope — a moving target 10.1038/s41579-019-0273-7
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis 10.1038/s41467-020-15876-8
Prophage-encoded phage defense proteins with cognate self-immunity 10.1101/2020.07.13.199331
6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis 10.1016/j.ejmech.2021.113843
Jun Liu
Liu Jun
ORCID: 0000-0002-0522-6733
The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation 10.1111/j.1462-5822.2006.00721.x
Targeting the global regulator Lsr2 as a novel approach for anti-tuberculosis drug development 10.1586/eri.12.86
Lsr2 of Mycobacterium Represents a Novel Class of H-NS-Like Proteins 10.1128/jb.00733-08
Roles of Lsr2 in Colony Morphology and Biofilm Formation of Mycobacterium smegmatis 10.1128/jb.188.2.633-641.2006
Mechanism of DNA organization by Mycobacterium tuberculosis protein Lsr2 10.1093/nar/gkt249
Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis 10.1073/pnas.0913551107
Lsr2 of Mycobacterium tuberculosis is a DNA-bridging protein 10.1093/nar/gkm1162
Differential productions of lipid virulence factors among BCG vaccine strains and implications on BCG safety 10.1016/j.vaccine.2007.09.041
BCG Vaccines: Their mechanisms of attenuation and impact on safety and protective efficacy 10.4161/hv.5.2.7210
Loss of Lipid Virulence Factors Reduces the Efficacy of the BCG Vaccine 10.1038/srep29076
Variable Virulence and Efficacy of BCG Vaccine Strains in Mice and Correlation With Genome Polymorphisms 10.1038/mt.2015.216
Novel genome polymorphisms in BCG vaccine strains and impact on efficacy 10.1186/1471-2164-9-413
Structural basis for targeting the ribosomal protein S1 of M ycobacterium tuberculosis by pyrazinamide 10.1111/mmi.12892
Hiding behind the mycobacterial cell wall 10.1016/j.tim.2014.01.004
Genome Sequencing and Analysis of BCG Vaccine Strains 10.1371/journal.pone.0071243
PhoY2 of Mycobacteria Is Required for Metabolic Homeostasis and Stress Response 10.1128/jb.01556-12
Silencing of foreign DNA in bacteria 10.1016/j.mib.2011.12.014
Both Phthiocerol Dimycocerosates and Phenolic Glycolipids Are Required for Virulence of Mycobacterium marinum 10.1128/iai.06370-11
PPE38 Modulates the Innate Immune Response and Is Required for Mycobacterium marinum Virulence 10.1128/iai.05249-11
Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease 10.1016/j.chembiol.2011.07.023
Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins 10.1073/pnas.1102544108
Whole-Genome Sequences of Four Mycobacterium bovis BCG Vaccine Strains 10.1128/jb.00405-11
MMAR_2770, a new enzyme involved in biotin biosynthesis, is essential for the growth of Mycobacterium marinum in macrophages and zebrafish 10.1016/j.micinf.2010.08.010
Malaria exacerbates experimental mycobacterial infection in vitro and in vivo 10.1016/j.micinf.2010.05.013
CD36 deficiency attenuates experimental mycobacterial infection 10.1186/1471-2334-10-299
Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507
MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium 10.1186/1471-2180-9-40
Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole 10.1128/iai.00614-08
Spontaneous transposition of IS1096 or ISMsm3 leads to glycopeptidolipid overproduction and affects surface properties in Mycobacterium smegmatis 10.1016/j.tube.2008.02.005
Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum 10.1111/j.1365-2958.2007.05603.x
Tuberculosis: Current Treatment and New Drug Development 10.2174/187152106778520433
AsnB Is Involved in Natural Resistance of Mycobacterium smegmatis to Multiple Drugs 10.1128/aac.50.1.250-255.2006
LosA, a Key Glycosyltransferase Involved in the Biosynthesis of a Novel Family of Glycosylated Acyltrehalose Lipooligosaccharides from Mycobacterium marinum 10.1074/jbc.m507500200
Impact of Methoxymycolic Acid Production by Mycobacterium bovis BCG Vaccines 10.1128/iai.72.5.2803-2809.2004
Acquisition of Hrs, an Essential Component of Phagosomal Maturation, Is Impaired by Mycobacteria 10.1128/mcb.24.10.4593-4604.2004
PimF, a Mannosyltransferase of Mycobacteria, Is Involved in the Biosynthesis of Phosphatidylinositol Mannosides and Lipoarabinomannan 10.1074/jbc.m400791200
pH-induced Conformational Changes of AcrA, the Membrane Fusion Protein of Escherichia coli Multidrug Efflux System 10.1074/jbc.m305152200
Mechanism of SMRT Corepressor Recruitment by the BCL6 BTB Domain 10.1016/s1097-2765(03)00454-4
A Rifampin-Hypersensitive Mutant Reveals Differences between Strains of Mycobacterium smegmatis and Presence of a Novel Transposon, IS1623 10.1128/aac.47.10.3208-3213.2003
Mycobacterium bovis BCG Vaccines Exhibit Defects in Alanine and Serine Catabolism 10.1128/iai.71.2.708-716.2003
Binding of ATP as Well as Tetrahydrofolate Induces Conformational Changes inLactobacillus caseiFolylpolyglutamate Synthetase in Solution† 10.1021/bi027024y
Central Region of the Human Splicing Factor Hprp3p Interacts with Hprp4p 10.1074/jbc.m111461200
Nramp1Modifies the Fusion ofSalmonella typhimurium-containing Vacuoles with Cellular Endomembranes in Macrophages 10.1074/jbc.m105508200
Cell Wall Structure of a Mutant of Mycobacterium smegmatis Defective in the Biosynthesis of Mycolic Acids 10.1074/jbc.275.10.7224
A mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids accumulates meromycolates 10.1073/pnas.96.7.4011
Two Modes of Ligand Binding in Maltose-binding Protein ofEscherichia coli: ELECTRON PARAMAGNETIC RESONANCE STUDY OF LIGAND-INDUCED GLOBAL CONFORMATIONAL CHANGES BY SITE-DIRECTED SPIN LABELING 10.1074/jbc.272.28.17610
Mycolic Acid Structure Determines the Fluidity of the Mycobacterial Cell Wall 10.1074/jbc.271.47.29545
Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump. 10.1128/jb.178.13.3791-3795.1996
Fluidity of the lipid domain of cell wall from Mycobacterium chelonae. 10.1073/pnas.92.24.11254
Denaturant Unfolding of the Ferric Enterobactin Receptor and Ligand-Induced Stabilization Studied by Site-Directed Spin Labeling 10.1021/bi00043a030
A Site-Directed Spin-Labeling Study of Ligand-Induced Conformational Change in the Ferric Enterobactin Receptor, FepA 10.1021/bi00249a014
Permeability properties of a large gated channel within the ferric enterobactin receptor, FepA. 10.1073/pnas.90.22.10653
Formation of a gated channel by a ligand-specific transport protein in the bacterial outer membrane 10.1126/science.1411544
Cell Wall: Physical Structure and Permeability 10.1002/9781444311433.ch12
Mycobacterial Genomes 10.1007/978-1-59745-152-9_9
A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaT 10.1371/journal.ppat.1004967
Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosis 10.1038/srep44826
The Impact of Genome Region of Difference 4 (RD4) on Mycobacterial Virulence and BCG Efficacy 10.3389/fcimb.2017.00239
Immunogenicity and Protective Efficacy of a Fusion Protein Tuberculosis Vaccine Combining Five Esx Family Proteins 10.3389/fcimb.2017.00226
WhiB4 Regulates the PE/PPE Gene Family and is Essential for Virulence of Mycobacterium marinum 10.1038/s41598-017-03020-4
A Mycobacterium smegmatis mutant with a defective inositol monophosphate phosphatase gene homolog has altered cell envelope permeability. 10.1128/jb.179.24.7827-7833.1997
Transcription factors Rv0081 and Rv3334 connect the early and the enduring hypoxic response of Mycobacterium tuberculosis 10.1080/21505594.2018.1514237
How bacterial xenogeneic silencer rok distinguishes foreign from self DNA in its resident genome 10.1093/nar/gky836
Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia 10.1038/s41426-018-0112-3
Recombinant BCG Overexpressing phoP-phoR Confers Enhanced Protection against Tuberculosis 10.1016/j.ymthe.2018.08.023
Mycobacterium tuberculosis 6C sRNA binds multiple mRNA targets via C-rich loops independent of RNA chaperones 10.1093/nar/gkz149
Transcriptome Changes of Mycobacterium marinum in the Process of Resuscitation From Hypoxia-Induced Dormancy. 10.3389/fgene.2019.01359
Mycobacterial Virulence Factors: Surface-Exposed Lipids and Secreted Proteins. 10.3390/ijms21113985
Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline 10.1038/s41586-020-3004-3
Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection 10.1016/j.immuni.2021.01.003
1H, 13C, and 15N resonance assignments of reduced apo-WhiB4 from Mycobacterium tuberculosis. 10.1007/s12104-020-09989-w
Xenogeneic Silencing and Bacterial Genome Evolution: Mechanisms for DNA Recognition Imply Multifaceted Roles of Xenogeneic Silencers. 10.1093/molbev/msab136
Preclinical Progress of Subunit and Live Attenuated Mycobacterium tuberculosis Vaccines: A Review following the First in Human Efficacy Trial. 10.3390/pharmaceutics12090848
Intranasal HD-Ad Vaccine Protects the Upper and Lower Respiratory Tracts of hACE2 Mice against SARS-CoV-2 10.1101/2021.04.08.439006
Roland Brosch
Brosch Roland
ORCID: 0000-0003-2587-3863
Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity. 10.1016/j.chom.2015.05.017
Insights on the emergence of Mycobacterium tuberculosis from the analysis of Mycobacterium kansasii 10.1093/gbe/evv035
Mycobacterial Pathogenomics and Evolution. 10.1128/microbiolspec.MGM2-0025-2013
Release of mycobacterial antigens 10.1111/imr.12251
Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice 10.1128/IAI.02032-14
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083
Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations 10.1038/srep15443
ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection 10.1016/j.tube.2015.02.019
Developing whole mycobacteria cell vaccines for tuberculosis: Workshop proceedings, Max Planck Institute for Infection Biology, Berlin, Germany, July 9, 2014 10.1016/j.vaccine.2015.03.056
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650
Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans | Les bacilles de la tuberculose bovine - Une évolution aux dépens de la transmissibilité chez l'homme 10.1051/medsci/20153102003
Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection 10.1371/journal.ppat.1003928
Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development 10.2217/fmb.14.70
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator 10.1073/pnas.1406693111
Bacillus calmette-guérin strain differences have an impact on clinical outcome in bladder cancer immunotherapy 10.1016/j.eururo.2014.02.061
A Specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies whiB6 as a novel ESX-1 component 10.1128/IAI.01824-14
A glimpse into the past and predictions for the future: The molecular evolution of the tuberculosis agent 10.1111/mmi.12720
TBCAP; Tuberculosis annotation project 10.1016/j.tube.2012.11.013
Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus 10.1111/mmi.12387
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis 10.1038/ng.2517
ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis 10.1111/cmi.12169
Characterization of Mycobacterium orygis 10.3201/eid1903.121005
The ESX-5 Associated eccB5-eccC5 Locus Is Essential for Mycobacterium tuberculosis Viability 10.1371/journal.pone.0052059
Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion-encoded PE-PPE proteins predicts vaccine potential 10.1016/j.chom.2012.03.003
Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death 10.1371/journal.ppat.1002507
Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh 10.1371/journal.pone.0040545
Molecular epidemiology of tuberculosis in rural Matlab, Bangladesh 10.5588/ijtld.11.0426
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria 10.1111/j.1462-5822.2012.01799.x
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells 10.4161/auto.20881
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation 10.1111/j.1365-2958.2012.08001.x
Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies 10.3201/eid1804.110888
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis 10.1002/eji.201141548
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways 10.1074/jbc.M111.223610
Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants 10.1111/j.1462-5822.2010.01565.x
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG 1on virulence of Mycobacterium tuberculosis 10.1093/infdis/jiq089
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237 10.1016/j.tube.2010.12.007
Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring 10.1016/j.ejmech.2010.09.048
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling 10.1371/journal.ppat.1001100
Entrapment of intracytosolic bacteria by septin cage-like structures 10.1016/j.chom.2010.10.009
Systematic genetic nomenclature for type VII secretion systems 10.1371/journal.ppat.1000507
Pathogenomics of mycobacteria 10.1159/000235772
Pathogenicity in the tubercle bacillus: Molecular and evolutionary determinants 10.1002/bies.200800191
Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus 10.1371/journal.pone.0005660
Myths and misconceptions: The origin and evolution of Mycobacterium tuberculosis 10.1038/nrmicro2165
Mycobacterial PE, PPE and ESX clusters: Novel insights into the secretion of these most unusual protein families 10.1111/j.1365-2958.2009.06784.x
High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors 10.1371/journal.ppat.1000645
ESX/type VII secretion systems and their role in host-pathogen interaction 10.1016/j.mib.2008.11.003
Benzothiazinones Kill Mycobacterium tuberculosis by blocking Arabinan synthesis 10.1126/science.1171583
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis 10.1101/gr.075069.107
Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism 10.1099/mic.0.2008/022269-0
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033
BCG: Molecular history and new perspectives | Le BCG: Histoire moléculaire et nouvelles perspectives RMR-06-2008-25-00-01761-8425-101019-200806495
Genome plasticity of BCG and impact on vaccine efficacy 10.1073/pnas.0700869104
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 10.1128/JB.00469-07
Pathogenomics: Insights into Tuberculosis and Related Mycobacterial Diseases 10.1002/352760801X.ch10
Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis 10.1093/molbev/msj120
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/IAI.74.1.88-98.2006
Contribution of mycobacterial genomics to the development of innovative strategies against tuberculosis | Apports de la génomique des mycobactéries a la définition de nouvelles stratégies thérapeutiques et vaccinales anti-tuberculeuses 10.1016/S1773-035X(06)80148-6
"A re-evaluation of M. prototuberculosis": Continuing the debate 10.1371/journal.ppat.0020095
Tuberculosis: From genome to vaccine 10.1586/14760584.4.4.541
Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against Oxidative Stress 10.1074/jbc.M503076200
Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: The contribution of endogenous mycolactone toxin 10.1111/j.1462-5822.2005.00546.x
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200
Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans 10.1128/JB.187.5.1668-1676.2005
Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis 10.1371/journal.ppat.0010005
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans 10.1073/pnas.0305877101
Genotypic Analysis of Mycobacterium tuberculosis in Bangladesh and Prevalence of the Beijing Strain 10.1128/JCM.42.2.674-682.2004
ESAT-6 proteins: Protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468
Cell Envelope Protein PPE68 Contributes to Mycobacterium tuberculosis RD1 Immunogenicity Independently of A 10-Kilodalton Culture Filtrate Protein and ESAT-6 10.1128/IAI.72.4.2170-2176.2004
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/nm859
Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex? [3] (multiple letters) 10.1128/JCM.41.3.1345-1348.2003
Royal society of tropical medicine and hygiene meeting at Manson house, London, 18 January 2001: Pathogen genomes and human health. Mycobacterial genomics 10.1016/S0035-9203(02)90222-1
Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysis 10.1128/JCM.40.7.2339-2345.2002
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant 10.1128/IAI.70.10.5568-5578.2002
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
The evolution of mycobacterial pathogenicity: Clues from comparative genomics 10.1016/S0966-842X(01)02131-X
Genomics of Mycobacterium bovis 10.1054/tube.2000.0269
Tools for the population genomics of the tubercle bacilli 10.1101/gr.169200
Comparative genomics of the leprosy and tubercle bacilli 10.1016/S0923-2508(00)00117-0
Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays 10.1046/j.1365-2958.1999.01383.x
Analysis of the proteome of Mycobacterium tuberculosis in silico 10.1054/tuld.1999.0220
The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes 10.1046/j.1365-2958.1998.01124.x
Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence 10.1038/31159
Genomic fingerprinting of 80 strains from the WHO multicenter international typing study of Listeria monocytogenes via pulsed-field gel electrophoresis (PFGE) 10.1016/S0168-1605(96)01147-6
Characterization of Listeria strains isolated from soft cheese 10.1016/0168-1605(93)90220-B
Listeriosis outbreak in France in 1992. Microbial data | Epidémie de listériose en France en 1992 aspects microbiologiques 10.1016/S0399-077X(05)81214-4
Use of pulsed field gel electrophoresis to compare large DNA-restriction fragments of Listeria monocytogenes strains belonging to serogroups 1/2 and 3 10.1016/0168-1605(91)90121-5
Subtyping of Listeria monocytogenes serovar 4b by use of low-frequency-cleavage restriction endonucleases and pulsed-field gel electrophoresis 10.1016/0923-2508(91)90080-T
Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions 10.1038/srep17078
Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis 10.1038/srep16918
Drug-resistant tuberculosis in the European Union: opportunities and challenges for control. 10.1016/j.tube.2010.03.008
The BCG Strain Pool: Diversity Matters. 10.1038/mt.2016.18
Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications. 10.1186/s12864-016-2448-1
Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access. 10.1111/cmi.12622
Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria 10.1073/pnas.1604921113
Comparative Genomics and Evolution of Mycobacterium bovis BCG 10.1128/9781555817657.ch10
The Mycobacteria: a Postgenomic View 10.1128/9781555815530.ch3
Genomics ofMycobacterium Tuberculosis and Mycobacterium Leprae 10.1002/9781444311433.ch5
Genomics of the Mycobacterium tuberculosis complex and Mycobacterium leprae 10.1002/047001153x.g205204
ESX secretion systems: mycobacterial evolution to counter host immunity 10.1038/nrmicro.2016.131
Resistance to thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384 10.1128/aac.02509-16
ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis. 10.1111/cmi.12726
Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis 10.1038/mi.2016.140
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection 10.1016/j.celrep.2017.02.057
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis 10.1371/journal.ppat.1006399
Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells 10.1038/s41598-017-05878-w
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101
Evolution of virulence in the Mycobacterium tuberculosis complex 10.1016/j.mib.2017.11.021
The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis 10.3389/fmicb.2017.02284
Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis 10.1038/s41564-017-0090-6
Discovery of the type VII ESX-1 secretion needle? 10.1111/mmi.13579
Identification of genes required forMycobacterium abscessusgrowth in vivo with a prominent role of the ESX-4 locus 10.1073/pnas.1713195115
Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions 10.1073/pnas.1620133114
Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation 10.1371/journal.ppat.1006752
The Biology and Epidemiology of Mycobacterium canettii 10.1007/978-3-319-64371-7_2
Targeting Type VII/ESX Secretion Systems for Development of Novel Antimycobacterial Drugs 10.2174/1381612819666131118170717
Taxonomic Diversity of Pseudomonads Revealed by Computer-interpretation of Ribotyping Data 10.1016/s0723-2020(96)80026-9
Comparative genomics of the mycobacteria 10.1016/s1438-4221(00)80083-1
Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens 10.3791/50116
Type VII Secretion Systems in Gram-Positive Bacteria 10.1007/82_2015_5015
Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: ‘Aethiops vetus’ 10.1099/mgen.0.000063
Leprosy in red squirrels 10.1126/science.aal0145
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection 10.1371/journal.ppat.1005770
pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence 10.1038/nmicrobiol.2015.19
A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence ofMycobacterium marinumin multiple hosts 10.1111/cmi.12606
The PE and PPE Protein Families of Mycobacterium tuberculosis 10.1002/9783527611614.ch7
Influence of ESAT-6 Secretion System 1 (RD1) of Mycobacterium tuberculosis on the Interaction between Mycobacteria and the Host Immune System 10.4049/jimmunol.174.6.3570
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125
ESAT-6–dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo 10.1172/jci84978
Cutting-edge science and the future of tuberculosis control 10.2471/blt.06.035386
ESAT-6 and the Mycobacterial ESX Secretion Systems 10.1128/9781555815783.ch13
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection 10.1371/journal.ppat.1007139
Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity 10.1093/gbe/evy145
New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach 10.1016/j.jprot.2018.09.013
Update on the virulence factors of the obligate pathogen Mycobacterium tuberculosis and related tuberculosis-causing mycobacteria 10.1016/j.meegid.2018.12.013
Shared Pathogenomic Patterns Characterize a New Phylotype, Revealing Transition toward Host-Adaptation Long before Speciation of Mycobacterium tuberculosis 10.1093/gbe/evz162
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis. 10.1021/acsnano.8b07902
Mycobacterial virulence: impact on immunogenicity and vaccine research 10.12688/f1000research.20572.1
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages 10.1038/s41467-020-14508-5
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis 10.1038/s41598-020-58967-8
ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins 10.1128/microbiolspec.psib-0029-2019
ESX-4, un système de sécrétion mycobactérien ancestral, essentiel pour la croissance de Mycobacterium abscessus dans les phagocytes environnementaux et humains 10.1051/medsci/2018196
Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages 10.1371/journal.ppat.1008069
A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies 10.1126/sciadv.aaz1767
Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential 10.1016/j.ebiom.2020.102761
Mucosal delivery of ESX-1–expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes 10.1073/pnas.2003235117
Le BCG : histoire moléculaire et nouvelles perspectives 10.1016/s0761-8425(08)56032-3
Breaching the phagosome, the case of the tuberculosis agent 10.1111/cmi.13344
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection 10.7554/elife.55692
IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo 10.1128/mSphere.00153-21
ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains 10.1128/mBio.00965-21
Evolution of Mycobacterium tuberculosis : New Insights into Pathogenicity and Drug Resistance 10.1128/microbiolspec.tbtb2-0020-2016
Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors 10.3389/fcimb.2020.00420
Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli 10.1038/s41564-021-00938-4
Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran