Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways
Jacob M. Wozniak Carlos A. Buscaglia Tatiana Araújo Silva Diane Thomas Jair L. Siqueira-Neto James H. McKerrow David J. Gonzalez Claudia M. Calvet
Jair Siqueira-Neto
Siqueira-Neto Jair
ORCID: 0000-0001-9574-8174
Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi 10.1016/j.bmc.2016.07.013
Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis 10.1371/journal.ppat.1005519
Open drug discovery for the Zika virus 10.12688/f1000research.8013.1
Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain 10.1021/acsmedchemlett.5600336
Current and Future Chemotherapy for Chagas Disease 10.2174/0929867322666151015120804
Drug Discovery for Human African Trypanosomiasis: Identification of Novel Scaffolds by the Newly Developed HTS SYBR Green Assay for Trypanosoma brucei 10.1177/1087057114556236
Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei 10.1021/acschembio.5b00308
Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease 10.1177/1087057114553103
Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery 10.1371/journal.pntd.0003878
Proteomic-Based Approach To Gain Insight into Reprogramming of THP-1 Cells Exposed to Leishmania donovani over an Early Temporal Window 10.1128/iai.02833-14
Shedding Light on Synergistic Chemical Genetic Connections with Machine Learning 10.1016/j.cels.2015.12.005
Synthesis and Evaluation of DNA Based Quantum Dot Fluorescence In Situ Hybridization (FISH) Probe for Telomere Detection 10.1166/jnn.2015.9500
Synthesis of a Sugar-Based Thiosemicarbazone Series and Structure-Activity Relationship versus the Parasite Cysteine Proteases Rhodesain, Cruzain, and Schistosoma mansoni Cathepsin B1 10.1128/aac.04601-14
Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase 10.1371/journal.pntd.0003588
4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency 10.1021/jm500448u
An Image-Based Algorithm for Precise and Accurate High Throughput Assessment of Drug Activity against the Human Parasite Trypanosoma cruzi 10.1371/journal.pone.0087188
Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 10.1021/jm501568b
Diversity-Oriented Synthesis Yields a New Drug Lead for Treatment of Chagas Disease 10.1021/ml400403u
RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain 10.1016/j.febslet.2014.11.005
Synthesis and biological evaluation of 2,3-dihydroimidazo 1,2-a benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi 10.1016/j.ejmech.2014.07.038
Synthesis and biological evaluation of 2-acetamidothiophene-3-carboxamide derivatives against Leishmania donovani 10.1039/c3md00299c
An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages 10.1371/journal.pntd.0001671
Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it? 10.1016/j.ijpddr.2012.01.003
Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds e675 10.1371/journal.pntd.0000675
The Leishmania amazonensis TRF ( TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeres 136 10.1186/1471-2180-10-136
Automated Nuclear Analysis of Leishmania major Telomeric Clusters Reveals Changes in Their Organization during the Parasite's Life Cycle e2313 10.1371/journal.pone.0002313
LaRbp38: A Leishmania amazonensis protein that binds nuclear and kinetoplast DNAs 10.1016/j.bbrc.2007.05.005
LaTBP1: A Leishmania amazonensis DNA-binding protein that associates in vivo with telomeres and GT-rich DNA using a Myb-like domain 10.1016/
Leishmania replication protein A-1 binds in vivo single-stranded telomeric DNA 10.1016/j.bbrc.2007.04.144
Telomere biology of trypanosomatids: beginning to answer some questions 10.1016/
The putative telomerase reverse transcriptase component of Leishmania amazonensis: gene cloning and characterization 10.1007/s00436-005-0036-4
Cysteine proteases in protozoan parasites 10.1371/journal.pntd.0006512
Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity 10.3390/molecules25071604
Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways 10.1371/journal.pntd.0007980
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole 10.1371/journal.pntd.0008726
Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi 10.1371/journal.pntd.0008728
Claudia Magalhães Calvet Alvarez
Magalhães Calvet Alvarez Claudia / Claudia M Calvet Alvarez / Claudia Magalhães Calvet
ORCID: 0000-0003-1275-1226
Trypanosoma cruzi infection of human induced pluripotent stem cell-derived cardiomyocytes: an in vitro model for drug screening for Chagas disease 10.1016/j.micinf.2018.03.002
Differential Role of TGF-β in Extracellular Matrix Regulation During Trypanosoma cruzi-Host Cell Interaction. 10.3390/ijms20194836
Synthesis, structure-activity relationship and trypanocidal activity of pyrazole-imidazoline and new pyrazole-tetrahydropyrimidine hybrids as promising chemotherapeutic agents for Chagas disease 10.1016/j.ejmech.2019.111610
Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity. 10.1021/acs.jmedchem.9b02078
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. 10.1021/acsmedchemlett.9b00453
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents. 10.1021/acs.jmedchem.8b01464
Natural products from marine red and brown algae against Trypanosoma cruzi 10.1016/j.bjp.2019.08.003
Molecular dissection of chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways 10.1371/journal.pntd.0007980
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents. 10.1016/j.ejmech.2018.06.063
Efficacy of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinone derivatives against different Trypanosoma cruzi discrete type units: Identification of a promising hit compound. 10.1016/j.ejmech.2017.12.052
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole 10.1371/journal.pntd.0008726
Jacob Wozniak
Wozniak Jacob
ORCID: 0000-0002-2453-0861
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function 10.1073/pnas.1917295117
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules 10.1016/j.cell.2017.12.032
American Gut: an Open Platform for Citizen Science Microbiome Research 10.1128/msystems.00031-18
Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr 10.1074/mcp.m116.066019
Defining Host Responses during Systemic Bacterial Infection through Construction of a Murine Organ Proteome Atlas 10.1016/j.cels.2018.04.010
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290
Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry 10.1074/mcp.tir118.001099
Optimization of carbon and energy utilization through differential translational efficiency 10.1038/s41467-018-06993-6
EGFR is required for Wnt9a–Fzd9b signalling specificity in haematopoietic stem cells 10.1038/s41556-019-0330-5
Organ-level protein networks as a reference for the host effects of the microbiome 10.1101/gr.256875.119
Quantitative analysis of Mycobacterium avium subsp. hominissuis proteome in response to antibiotics and during exposure to different environmental conditions 10.1186/s12014-019-9260-2
AssessORF: combining evolutionary conservation and proteomics to assess prokaryotic gene predictions 10.1093/bioinformatics/btz714
PTMphinder: an R package for PTM site localization and motif extraction from proteomic datasets 10.7717/peerj.7046
Functional and Proteomic Analysis of Streptococcus pyogenes Virulence Upon Loss of Its Native Cas9 Nuclease 10.3389/fmicb.2019.01967
Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways 10.1371/journal.pntd.0007980
Mortality Risk Profiling of Staphylococcus aureus Bacteremia by Multi-omic Serum Analysis Reveals Early Predictive and Pathogenic Signatures 10.1016/j.cell.2020.07.040
CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly 10.1073/pnas.2018251118
Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption 10.1126/scisignal.abc1044