Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms
Christopher Fernandez-Prada
Isabel M. Vincent
Marie-Christine Brotherton
Mathew Roberts
Gaétan Roy
Luis Rivas
Philippe Leprohon
Terry K. Smith
Marc Ouellette
Louis Maes
Luis Rivas
Rivas Luis
ORCID: 0000-0002-2958-3233
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Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms
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Functional analysis and complex gene rearrangements of the folate/biopterin transporter (FBT) gene family in the protozoan parasite Leishmania
10.1016/j.molbiopara.2008.08.007
Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species
10.1186/1471-2164-9-255
Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors
10.1086/592280
Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy
10.1186/gb-2008-9-7-r115
Modulation of gene expression in human macrophages treated with the anti-leishmania pentavalent antimonial drug sodium stibogluconate
10.1128/AAC.01183-07
A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death
10.1074/mcp.M600319-MCP200
A recombinant non-pathogenic Leishmania vaccine expressing human immunodeficiency virus 1 (HIV-1) Gag elicits cell-mediated immunity in mice and decreases HIV-1 replication in human tonsillar tissue following exposure to HIV-1 infection
10.1099/vir.0.81995-0
Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis
10.1111/j.1365-2958.2007.05845.x
Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains
10.1021/pr070521m
Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs
10.1007/s00436-007-0638-0
HIV-1 replication is stimulated by sodium stibogluconate, the therapeutic mainstay in the treatment of leishmaniasis
10.1086/510398
Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani
10.1093/jac/dkl494
Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes
10.1128/AAC.00404-07
A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum
10.1002/pmic.200500853
Identification of developmentally-regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes
10.1016/j.molbiopara.2006.01.008
In primary human monocyte-derived macrophages exposed to Human immunodeficiency virus type 1, does the increased intracellular growth of Leishmania infantum rely on its enhanced uptake?
10.1099/vir.0.81647-0
Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites
10.1128/EC.00152-06
Prefractionation by digitonin extraction increases representation of the cytosolic and intracellular proteome of Leishmania infantum
10.1021/pr060081j
Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase
10.1128/AAC.50.1.88-95.2006
Resistance to antimony and treatment failure in human Leishmania (Viannia) infection
10.1086/503371
Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania
10.1016/j.molbiopara.2006.06.009
Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites
10.1371/journal.pmed.0030162
A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter
10.1111/j.1365-2958.2005.04914.x
Live nonpathogenic parasitic vector as a candidate vaccine against visceral leishmaniasis
10.1128/IAI.73.10.6372-6382.2005
Microfluidic device for rapid (<15 min) automated microarray hybridization
10.1373/clinchem.2005.052845
Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania
10.1111/j.1365-2958.2005.04782.x
Phylogeny of the Enterobacteriaceae based on genes encoding elongation factor Tu and F-ATPase beta-subunit
10.1099/ijs.0.63539-0
Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes
10.1128/AAC.49.5.1988-1993.2005
Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance
10.1074/jbc.M405183200
Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin
10.1074/jbc.M403959200
Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistance
10.1074/jbc.M409264200
Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate
10.1074/jbc.M400652200
Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam
10.1074/jbc.M404383200
Leishmaniasis: drugs in the clinic, resistance and new developments
10.1016/j.drup.2004.07.002
Use of tuf sequences for genus-specific PCR detection and phylogenetic analysis of 28 streptococcal species
10.1128/JCM.42.8.3686-3695.2004
Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance
10.1074/jbc.M308352200
Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms
10.1074/mcp.M200085-MCP200
[Studies on the parasite Leishmania in the post-genomic era]
10.1051/medsci/20031910900
A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells
10.1074/jbc.M204796200
A proteomic approach to identify developmentally regulated proteins in Leishmania infantum
10.1002/1615-9861(200208)2:8<1007::AID-PROT1007>3.0.CO;2-G
Involvement of zinc in the binding of Mycoplasma arthritidis-derived mitogen to the proximity of the HLA-DR binding groove regardless of histidine 81 of the beta chain
10.1002/1521-4141(200201)32:1<50::AID-IMMU50>3.0.CO;2-A
Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin
10.1006/expr.2001.4595
Development of a PCR assay for identification of staphylococci at genus and species levels
10.1128/JCM.39.7.2541-2547.2001
DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening
10.1128/AAC.45.4.1168-1173.2001
Gene amplification in amphotericin B-resistant Leishmania tarentolae
10.1006/expr.2001.4663
The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase
10.1074/jbc.M102351200
Binding of Mycoplasma arthritidis-derived mitogen to human MHC class II molecules via its N terminus is modulated by invariant chain expression and its C terminus is required for T cell activation
10.1002/1521-4141(200006)30:6<1748::AID-IMMU1748>3.0.CO;2-J
Rapid detection of group B streptococci in pregnant women at delivery
10.1056/NEJM200007203430303
ATP-binding cassette transporters: from multidrug resistance to genetic disease, Gosau, Austria, 20-27 February 1999
10.1054/drup.1999.0072
Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae
10.1093/emboj/18.9.2342
Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae
10.1093/emboj/16.11.3057
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages
10.1093/emboj/16.10.2590
Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania
10.1006/expr.1997.4222
Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1
10.1006/abbi.1997.0126
Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene
10.1006/expr.1996.4115
Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae
10.1006/bbrc.1996.1098
New mechanisms of drug resistance in parasitic protozoa
10.1146/annurev.mi.49.100195.002235
Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei
10.1038/348174a0
Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
10.1371/journal.pntd.0009377
Christopher Fernandez-Prada
Fernandez-Prada Christopher
/ Christopher F Prada
ORCID: 0000-0003-4834-4956
Drug resistance analysis by next generation sequencing in Leishmania
10.1016/j.ijpddr.2014.09.005
Trypanosomatids see the light: Recent advances in bioimaging research
10.1016/j.drudis.2014.09.012
Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery
10.1016/j.ijpddr.2014.07.006
Synthesis of marine α-methoxylated fatty acid analogs that effectively inhibit the topoisomerase IB from leishmania donovani with a mechanism different from that of camptothecin
10.3390/md11103661
Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB.
10.1371/journal.pone.0073565
Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect
10.1016/j.bcp.2013.02.024
A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity
10.1016/j.bbagen.2012.09.005
2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani
10.1016/j.bmcl.2012.08.019
Indotecan (LMP400) and AM13-55: Two novel indenoisoquinolines show potential for treating visceral leishmaniasis
10.1128/AAC.00499-12
First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme
10.1351/PAC-CON-11-10-21
Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis
10.1016/j.molbiopara.2011.10.007
Appraisal of a Leishmania major Strain Stably Expressing mCherry Fluorescent Protein for Both In Vitro and In Vivo Studies of Potential Drugs and Vaccine against Cutaneous Leishmaniasis
10.1371/journal.pntd.0001927
First total synthesis and antileishmanial activity of (Z)-16-methyl-11-heptadecenoic acid, a new marine fatty acid from the sponge Dragmaxia undata.
10.1016/j.chemphyslip.2010.11.006
DNA topoisomerases in apicomplexan parasites: Promising targets for drug discovery
10.1098/rspb.2009.2176
Total synthesis and antileishmanial activity of the natural occurring acetylenic fatty acids 6-heptadecynoic acid and 6-icosynoic acid
10.1007/s11745-009-3345-z
First total synthesis and antiprotozoal activity of (Z)-17-methyl-13-octadecenoic acid, a new marine fatty acid from the sponge Polymastia penicillus
10.1016/j.chemphyslip.2009.06.140
Novel findings on trypanosomatid chemotherapy using DNA topoisomerase inhibitors
10.2174/138955709788452775
Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania
10.1073/pnas.1520693113
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms
10.1371/journal.pntd.0005171
High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms
10.1016/j.ijpddr.2018.03.004
High-throughput identification and quantification of Haemonchus contortus in fecal samples
https://doi.org/10.1016/j.vetpar.2018.11.017
A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria
https://doi.org/10.1016/j.micpath.2019.03.025
Chapter 5 - Repurposed Molecules: A New Hope in Tackling Neglected Infectious Diseases
https://doi.org/10.1016/B978-0-12-816125-8.00005-5
Cos-Seq: A High-Throughput Gain-of-Function Screen for Drug Resistance Studies in Leishmania
10.1007/978-1-4939-9210-2_7
Leishmania and its exosomal pathway: a novel direction for vaccine development
10.2217/fmb-2019-0087
Innovative Solutions for the Control of Leishmaniases: Nanoscale Drug Delivery Systems
10.2174/1381612825666190621154552
Leishmania Viannia guyanensis
10.1016/j.pt.2019.06.008
High-throughput identification and quantification of Haemonchus contortus in fecal samples
10.1016/j.vetpar.2018.11.017
A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria
10.1016/j.micpath.2019.03.025
Chapter 6: Omics and Their Impact on the Development of Chemotherapy Against Leishmania
10.1039/9781788010177-00101
Effects of recycled manure solids bedding on the spread of gastrointestinal parasites in the environment of dairies and milk
10.3168/jds.2019-16866
MRPA-independent mechanisms of antimony resistance in Leishmania infantum
10.1016/j.ijpddr.2020.03.003
Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery
10.3390/genes11070722
Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites
10.1371/journal.pntd.0008439
Extracellular vesicles and leishmaniasis: Current knowledge and promising avenues for future development
10.1016/j.molimm.2021.04.003
Extracellular Vesicles in Trypanosomatids: Host Cell Communication.
10.3389/fcimb.2020.602502
Three Different Mutations in the DNA Topoisomerase 1B in Leishmania Infantum Contribute to Resistance to Antitumor Drug Topotecan
10.21203/rs.3.rs-527648/v1
Influence of N-Methylation and Conformation on Almiramide Anti-Leishmanial Activity
10.3390/molecules26123606
Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan
10.1186/s13071-021-04947-4
