GAD2 on chromosome 10p12 is a candidate gene for human obesity
Boutin, P. Dina, C. Vasseur, F. Dubois, S. Corset, L. Seron, K. Bekris, L. Cabellon, J. Neve, B. Vasseur-Delannoy, V. Chikri, M. Charles, M. A. Clement, K. Lernmark, A. Froguel, P.
Plos Biology, 2003
https://doi.org/10.1371/journal.pbio.0000068
Karin Seron
Seron Karin
ORCID: 0000-0002-9667-133X
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Abnormal glucose tolerance during pregnancy in Pima Indian women. Long-term effects on offspring. 10.2337/diab.40.2.s126
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To which extent social withdrawal at the age of 1 year is associated with IQ at 5-6 years old? Results of the EDEN mother-child cohort. 10.1007/s00787-017-0988-9
Joint Bayesian weight and height postnatal growth model to study the effects of maternal smoking during pregnancy 10.1002/sim.7407
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Mediation and modification of genetic susceptibility to obesity by eating behaviors. 10.17863/CAM.12336
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Additional file 1: of Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania 10.6084/m9.figshare.7300868
Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania 10.6084/m9.figshare.c.4291475
Additional file 1: of Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania 10.6084/m9.figshare.7300868.v1
Additional file 1: Figure S1. of Early determinants of food liking among 5y-old children: a longitudinal study from the EDEN mother-child cohort 10.6084/m9.figshare.c.3605687_d1.v1
Additional file 2: Figure S2. of Early determinants of food liking among 5y-old children: a longitudinal study from the EDEN mother-child cohort 10.6084/m9.figshare.c.3605687_d2.v1
Night-waking trajectories and behavior in preschool-aged children from the EDEN birth-cohort 10.13140/rg.2.2.25459.53283
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Early determinants of food liking among 5y-old children: a longitudinal study from the EDEN mother-child cohort 10.6084/m9.figshare.c.3605687
Additional file 1: Figure S1. of Early determinants of food liking among 5y-old children: a longitudinal study from the EDEN mother-child cohort 10.6084/m9.figshare.c.3605687_d1
Implication of the Pro12Ala polymorphism of the gene in type 2 diabetes and obesity in the French population-1 10.6084/m9.figshare.50867.v1
Implication of the Pro12Ala polymorphism of the gene in type 2 diabetes and obesity in the French population-1 10.6084/m9.figshare.50867
Allelic frequency of the Pro12Ala polymorphism in non diabetic and type 2 diabetic subjects (T2D) stratified according to obesity status 10.6084/m9.figshare.34283.v1
Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research 10.7892/boris.41062
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Association between genetic obesity susceptibility and mother-reported eating behaviour in children up to 5 years. 10.17863/cam.36640
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Infant feeding practices and sleep development in pre-schoolers from the EDEN mother-child cohort. 10.1111/jsr.12859
Frequency of Use of Added Sugar, Salt, and Fat in Infant Foods up to 10 Months in the Nationwide ELFE Cohort Study: Associated Infant Feeding and Caregiving Practices. 10.3390/nu11040733
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Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American, and Australian cohorts. 10.1111/1471-0528.15661
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Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood. 10.1111/pai.12998
Are selection criteria for healthy pregnancies responsible for the gap between fetal growth in the French national Elfe birth cohort and the Intergrowth-21st fetal growth standards? 10.1111/ppe.12526
The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers. 10.1111/ppe.12519
Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania. 10.1186/s12916-018-1189-1
Breastfeeding initiation and duration in France: The importance of intergenerational and previous maternal breastfeeding experiences - results from the nationwide ELFE study. 10.1016/j.midw.2018.10.020
Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort. 10.1016/j.sleep.2018.09.017
Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis. 10.1016/S2352-4642(18)30273-6
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Use of partially hydrolysed formula in infancy and incidence of eczema, respiratory symptoms or food allergies in toddlers from the ELFE cohort 10.1111/pai.13094
An association between maternal weight change in the year before pregnancy and infant birth weight: ELFE, a French national birth cohort study 10.1371/journal.pmed.1002871
Cohort Profile: The French national cohort of children (ELFE): birth to 5 years 10.1093/ije/dyz227
Reply to J. Heinrich 10.1111/pai.13146
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GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. 10.17863/cam.48335
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Diet during pregnancy: Influence of social characteristics and migration in the ELFE cohort 10.1111/mcn.13140
Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study. 10.1186/s12879-021-05864-8
Characterization of Infant Feeding Practices and Related-Family Characteristics in the French Nationwide ELFE Birth Cohort. 10.3390/nu13010033
Characteristics associated with feeding organic foods during complementary feeding: the nationwide Étude Longitudinale Française depuis l'Enfance (ELFE) birth cohort. 10.1017/s0007114520005097
Pregnancy outcomes in women with preexisting thyroid diseases: a French cohort study. 10.1017/s2040174420001051
Seroprevalence of SARS-CoV-2 Among Adults in Three Regions of France Following the Lockdown and Associated Risk Factors: A Multicohort Study 10.2139/ssrn.3696820
Incidence and Risk Factors of Illnesses Presumably Caused by A SARS-CoV-2 Infection in The General Population During The Lockdown Period: A Multi-Cohort Study. 10.21203/rs.3.rs-90873/v1
Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions. 10.1186/s12916-020-01736-1
Seroprevalence of SARS-CoV-2 among adults in three regions of France following the lockdown and associated risk factors: a multicohort study. 10.1101/2020.09.16.20195693
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. 10.1371/journal.pgen.1008718
Infant feeding practices and sleep at 1 year of age in the nationwide ELFE cohort. 10.1111/mcn.13072
Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births. 10.1371/journal.pmed.1003182
The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents. 10.1007/s10654-020-00662-z
Night-sleep Duration Trajectories and Behavior in Preschoolers: Results from a Prospective Birth Cohort Study. 10.1080/15402002.2020.1773467
Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood. 10.1038/s41598-020-62576-w
Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry. 10.3390/nu12030838
Measuring Child Socio-Economic Position in Birth Cohort Research: The Development of a Novel Standardized Household Income Indicator. 10.3390/ijerph17051700
Does cord blood leptin level mediate the association between neonatal body size and postnatal growth? Results from the EDEN mother-child cohort study. 10.1080/03014460.2020.1748712
Clusters of diet, physical activity, television exposure and sleep habits and their association with adiposity in preschool children: the EDEN mother-child cohort. 10.1186/s12966-020-00927-6
Breastfeeding initiation or duration and longitudinal patterns of infections up to 2 years and skin rash and respiratory symptoms up to 8 years in the EDEN mother-child cohort. 10.1111/mcn.12935
Postpartum psychological distress associated with anal incontinence in the EDEN mother-child cohort. 10.1111/1471-0528.16075
Maternal cumulative exposure to extremely low frequency electromagnetic fields, prematurity and small for gestational age: a pooled analysis of two birth cohorts. 10.1136/oemed-2019-105785
Sleep habits and sleep characteristics at age one year in the ELFE birth cohort study. 10.1016/j.sleep.2019.11.1255
Maternal exposure to cigarette smoking induces immediate and durable changes in placental DNA methylation affecting enhancer and imprinting control regions 10.1101/852186
Multiple pesticides in mothers' hair samples and children's measurements at birth: Results from the French national birth cohort (ELFE). 10.1016/j.ijheh.2019.10.010
A big-data approach to producing descriptive anthropometric references: a feasibility and validation study of paediatric growth charts. 10.1016/s2589-7500(19)30149-9
Exposure to Bisphenol A and Bisphenol S and Incident Type 2 Diabetes: A Case-Cohort Study in the French Cohort D.E.S.I.R. 10.1289/ehp5159
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. 10.1126/sciadv.aaw3095
Which modifiable prenatal factors mediate the relation between socio-economic position and a child's weight and length at birth? 10.1111/mcn.12878
Residential sources of pesticide exposure during pregnancy and the risks of hypospadias and cryptorchidism: the French ELFE birth cohort. 10.1136/oemed-2019-105801
Maternity or parental leave and breastfeeding duration: Results from the ELFE cohort. 10.1111/mcn.12872
Benefits of cooperation among large-scale cohort studies and human biomonitoring projects in environmental health research: An exercise in blood lead analysis of the Environment and Child Health International Birth Cohort Group. 10.1016/j.ijheh.2019.07.005
Breastfeeding Status and Duration and Infections, Hospitalizations for Infections, and Antibiotic Use in the First Two Years of Life in the ELFE Cohort. 10.3390/nu11071607
Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth 10.1101/663567
Night sleep duration trajectories and associated factors among preschool children from the EDEN cohort. 10.1016/j.sleep.2018.03.030
Associations between Children’s Genetic Susceptibility to Obesity, Infant’s Appetite and Parental Feeding Practices in Toddlerhood 10.3390/nu13051468
Associations between Children's Genetic Susceptibility to Obesity, Infant's Appetite and Parental Feeding Practices in Toddlerhood. 10.17863/cam.69676
Ake Lernmark
Lernmark Ake
ORCID: 0000-0003-1735-0499
Etiopathogenesis of Insulin Autoimmunity 10.1155/2012/457546
HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes 10.1007/s00592-017-1063-1
First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age 10.1016/j.jri.2018.02.004
Metabolite-related dietary patterns and the development of islet autoimmunity 10.1038/s41598-019-51251-4
Autoimmunity in insulin-dependent diabetes mellitus 10.1016/0002-9343(81)90420-4
EFFECTS ON THE ENDOCRINE PANCREAS IN CHINESE HAMSTERS FED ZINC DEFICIENT DIETS 10.1111/j.1699-0463.1969.tb03252.x
Effect of epinephrine and mannoheptulose on early and late phases of glucose-stimulated insulin release 10.1016/0026-0495(70)90018-1
Effects of phlorizin on metabolism and function of pancreatic β-cell 10.1016/0026-0495(72)90020-0
Flow injection fluorescence microscopy applied to a rapid cell surface immunoassay 10.1002/cyto.990190109
Flow-injection immunoassays: Present and future 10.1016/0026-265X(92)90003-L
Humoral immunity in the spontaneously diabetic BB rat 10.1016/S0026-0495(83)80018-3
ISLET AUTOANTIBODIES IN HUMAN PANCREATIC TRANSPLANT RECIPIENTS 10.1016/S0140-6736(79)91407-7
Immunology of the beta cell 10.1016/S1056-8727(00)00116-1
Immunomodulation with human recombinant autoantigens 10.1016/j.it.2005.08.015
Low-Dose Streptozotocin Induces Sustained Hyperglycemia in Macaca nemestrina 10.3109/08916930108995995
Multiple sclerosis and type 1 diabetes: an unlikely alliance 10.1016/S0140-6736(02)08464-7
Rapid-Onset Type 1 Diabetes with Pancreatic Exocrine Dysfunction 10.1056/NEJM200002033420508
The genetics of susceptibility to diabetes 10.1016/0090-1229(89)90002-0
The pancreatic β-cell recognition of insulin secretagogues—III 10.1016/0006-2952(73)90251-7
The β-cell capacity for insulin secretion in microdissected pancreatic islets from obese-hyperglycemic mice 10.1016/0024-3205(69)90117-9
Type 1 Diabetes — Does Suppressing T Cells Increase Insulin? 10.1056/NEJMe058114
Åke Lernmark - Co-Editor-in-Chief 10.1055/s-2007-978996
Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study 10.2337/DB20-0696
Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes 10.2337/DB20-0374
Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort 10.1007/S11306-020-01730-X
Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study 10.2337/DC19-2547
Immunocyte single cell analysis of vaccine-induced narcolepsy 10.1002/EJI.202048633
Motifs of Three HLA-DQ Amino Acid Residues (alpha 44, beta 57, beta 135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children 10.2337/DB20-0075
Periodontal conditions, retinopathy, and serum markers in individuals with type 1 diabetes 10.1002/JPER.19-0641
Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates 10.1007/S00125-019-05066-7
Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study 10.2337/DB19-0756
Screening for autoantibody targets in post-vaccination narcolepsy using proteome arrays 10.1111/SJI.12864
Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study 10.1007/S00125-019-05028-Z
Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study 10.2337/DC19-0747
Autoimmune (Type 1) Diabetes 10.1016/B978-0-12-812102-3.00041-5
Prospective virome analyses in young children at increased genetic risk for type 1 diabetes 10.1038/S41591-019-0667-0
HLA high-resolution typing by next-generation sequencing in Pandemrix-induced narcolepsy 10.1371/JOURNAL.PONE.0222882
Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study 10.1136/JMEDGENET-2018-105532
Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes 10.2337/DB19-0273
Autoantibodies in Pandemrix (R)-induced narcolepsy: Nine candidate autoantigens fail the conformational autoantibody test 10.1080/08916934.2019.1643843
Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes 10.2337/DB18-1128
A Combined Method Improves Risk Prediction for Childhood Type 1 Diabetes in the TEDDY Study 10.2337/DB19-210-OR
Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report 10.2337/DC18-2282
Presymptomatic and Clinical T1D in The US, Sweden, and Finland: Joint Analysis of Four Birth Cohort Studies 10.2337/DB19-1345-P
A Rule-Based Discovery of Gene-Environment Interactions on Risk of Islet Autoimmunity: TEDDY Study 10.2337/DB19-1682-P
Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes 10.1007/S00125-019-4811-7
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families 10.2337/DB18-0882
Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study 10.1111/PEDI.12794
Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children 10.2337/DB18-0594
The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update 10.1007/S11892-018-1113-2
Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes 10.2337/DB18-0355
Temporal development of the gut microbiome in early childhood from the TEDDY study 10.1038/S41586-018-0617-X
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Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort 10.1016/J.JAUT.2017.12.008
Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats 10.1007/S00125-017-4512-Z
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Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study 10.1097/MPG.0000000000001682
GAD2 on chromosome 10p12 is a candidate gene for human obesity 10.1371/JOURNAL.PBIO.0000068
Pandemrix (R) vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children 10.1007/S00125-017-4448-3
Early Infant Diet and Islet Autoimmunity in the TEDDY Study 10.2337/DC17-1983
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Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity 10.2337/DB17-0802
Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident beta-cell autoantibodies 10.1016/J.JAUT.2017.09.005
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D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus 10.1007/S00125-005-0011-8
Understanding and preventing type 1 diabetes through the unique working model of TrialNet (Pg 2139, Vol 60, 2017) 10.1007/S00125-017-4446-5
Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls 10.1111/PEDI.12485
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Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity 10.1001/JAMAPEDIATRICS.2017.2905
Understanding and preventing type 1 diabetes through the unique working model of TrialNet 10.1007/S00125-017-4384-2
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Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity 10.1542/PEDS.2017-2424
Building and validating a prediction model for paediatric type 1 diabetes risk using next generation targeted sequencing of class II HLA genes 10.1002/DMRR.2921
Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study 10.1007/S00125-017-4365-5
Antibody Affinity Against 2009 A/H1N1 Influenza and Pandemrix Vaccine Nucleoproteins Differs Between Childhood Narcolepsy Patients and Controls 10.1089/VIM.2017.0066
Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study 10.2337/DC17-0238
Early prediction of autoimmune (type 1) diabetes 10.1007/S00125-017-4308-1
The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study 10.1002/DEV.21523
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Thyroid and Islet Autoantibodies Predict Autoimmune Thyroid Disease at Type 1 Diabetes Diagnosis 10.1210/JC.2016-2335
Type 1 diabetes mellitus 10.1038/NRDP.2017.16
An Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type I Diabetes May Be Related to I-ILA-DQ8 10.2337/DB16-0891
First Infant Formula Type and Risk of Islet Autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study 10.2337/DC16-1624
Longitudinal analysis of hepatic transcriptome and serum metabolome demonstrates altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic biobreeding rats 10.1371/JOURNAL.PONE.0171372
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Islet autoantibodies present in association with Ljungan virus infection in bank voles (Myodes glareolus) in northern Sweden 10.1002/JMV.24597
Islet cell autoantibody levels after the diagnosis of young adult diabetic patients 10.1111/J.1464-5491.2007.02235.X
Are Perinatal Events Risk Factors for Childhood Thyroid Autoimmunity? 10.1159/000479964
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types 10.1038/NCOMMS13555
Pancreas volume and fat fraction in children with Type 1 diabetes 10.1111/DME.13115
The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes 10.3109/08916934.2010.540604
Altered regulatory T cell phenotype in latent autoimmune diabetes of the adults (LADA) 10.1111/CEI.12834
A NOVEL RADIOLIGAND BINDING ASSAY TO DETERMINE DIAGNOSTIC-ACCURACY OF ISOFORM-SPECIFIC GLUTAMIC-ACID DECARBOXYLASE ANTIBODIES IN CHILDHOOD IDDM 10.1007/S001250050115
Association between HLA and islet cell antibodies in diabetic patients with a mitochondrial DNA mutation at base pair 3243 10.1007/BF02658506
Reversion of beta-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study 10.2337/DC16-0181
Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study 10.2337/DB15-1180
Environmental factors in the etiology of type 1 diabetes, celiac disease, and narcolepsy 10.1111/PEDI.12390
Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study 10.1038/SREP27887
Genetic risk factors for type 1 diabetes 10.1016/S0140-6736(16)30582-7
Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes 10.1007/S00125-008-1074-0
An Object-Oriented Regression for Building Disease Predictive Models with Multiallelic HLA Genes 10.1002/GEPI.21968
Factors associated with longitudinal food record compliance in a paediatric cohort study 10.1017/S1368980015001883
Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort 10.1016/J.CGH.2015.09.030
Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes 10.2337/DB15-1115
Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents 10.1007/S00125-013-2934-9
Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment 10.1007/S00125-015-3789-Z
Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study 10.1001/JAMAPEDIATRICS.2015.2757
Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients 10.1111/PEDI.12222
Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies 10.1038/GENE.2015.43
Prevalence of celiac disease autoimmunity in children with type 1 diabetes: regional variations across the Oresund strait between Denmark and southernmost Sweden 10.1111/PEDI.12200
Doubly Reactive INS-IGF2 Autoantibodies in Children with Newly Diagnosed Autoimmune (type 1) Diabetes 10.1111/SJI.12325
Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association 10.2337/DC15-1419
Determination of 21-hydroxylase autoantibodies: inter-laboratory concordance in the Euradrenal International Serum Exchange Program 10.1515/CCLM-2014-1106
Magnetic resonance imaging reveals altered distribution of hepatic fat in children with type 1 diabetes compared to controls 10.1016/J.METABOL.2015.04.002
Dietary intake of soluble fiber and risk of islet autoimmunity by 5 y of age: results from the TEDDY study 10.3945/AJCN.115.108159
IMPROVED SPECIFICITY OF ICA ASSAYS IN THE 4TH INTERNATIONAL-IMMUNOLOGY-OF-DIABETES-SERUM-EXCHANGE-WORKSHOP 10.2337/DIABETES.41.12.1570
Serological Evaluation of Possible Exposure to Ljungan Virus and Related Parechovirus in Autoimmune (Type 1) Diabetes in Children 10.1002/JMV.24127
Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome 10.1038/SREP11196
Baseline heterogeneity in glucose metabolism marks the risk for type 1 diabetes and complicates secondary prevention 10.1007/S00592-014-0680-1
Plasma GAD65, a Marker for Early beta-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients 10.1210/JC.2015-1216
The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study 10.1007/S00125-015-3514-Y
Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study 10.2337/DB14-1497
The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus 10.1007/S00125-009-1351-6
Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY) 10.2337/DC14-2426
The Streetlight Effect-Is There Light at the End of the Tunnel? 10.2337/DB15-0011
A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY 10.1186/S12887-015-0333-8
Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients 10.1111/CEI.12448
The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus 10.1007/S001250050774
Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes 10.2337/DC14-0850
Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index 10.1007/S001250051194
Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA 10.1172/JCI74961
A Functional Polymorphism of Ptpn22 Is Associated with Type 1 Diabetes in the BioBreeding Rat 10.4049/JIMMUNOL.1302689
Reduced morbidity at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up 10.1111/PEDI.12151
Lack of Evidence for a Role of Islet Autoimmunity in the Aetiology of Canine Diabetes Mellitus 10.1371/JOURNAL.PONE.0105473
Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies 10.1111/PEDI.12093
Stability of disease-associated antibody titers in pregnant women with type 1 diabetes with or without residual beta-cell function 10.2337/DIACARE.23.7.1019
Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study 10.1002/DMRR.2510
GAD Autoantibody Affinity in Adult Patients With Latent Autoimmune Diabetes, the Study Participants of a GAD65 Vaccination Trial 10.2337/DC13-1719
A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010 10.1016/J.JAUT.2014.01.031
Carl-David Agardh, 1946-2013 IN MEMORIAM 10.1007/S00125-014-3182-3
Variability in the CIITA gene interacts with HLA in multiple sclerosis 10.1038/GENE.2013.71
High Plasma Levels of Islet Amyloid Polypeptide in Young with New-Onset of Type 1 Diabetes Mellitus 10.1371/JOURNAL.PONE.0093053
Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease 10.1111/PEDI.12066
Antibodies to Influenza Virus A/H1N1 Hemagglutinin in Type 1 Diabetes Children Diagnosed Before, During and After the SWEDISH A(H1N1)pdm09 Vaccination Campaign 2009-2010 10.1111/SJI.12138
Is there evidence for post-translational modification of beta cell autoantigens in the aetiology and pathogenesis of type 1 diabetes? 10.1007/S00125-013-3041-7
Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1(star)0602 genotypes and islet cell autoantibodies 10.1111/J.1464-5491.2011.03359.X
Depleting T Cells in Newly Diagnosed Autoimmune (Type 1) Diabetes-Are We Getting Anywhere? 10.2337/DB13-1207
Decreased Cord-Blood Phospholipids in Young Age-at-Onset Type 1 Diabetes 10.2337/DB13-0215
Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy 10.1016/J.JDIACOMP.2013.06.007
Autoimmunity against INS-IGF2 Protein Expressed in Human Pancreatic Islets 10.1074/JBC.M113.478222
Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY 10.1002/DMRR.2427
Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes 10.1007/S00125-013-2924-Y
Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study 10.1111/PEDI.12023
GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoinimune diabetes 10.2337/DIACARE.25.8.1481
Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset 10.1080/08916930500407238
Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression 10.2337/DB12-1273
Decline in Titers of Anti-Idiotypic Antibodies Specific to Autoantibodies to GAD65 (GAD65Ab) Precedes Development of GAD65Ab and Type 1 Diabetes 10.1371/JOURNAL.PONE.0065173
The BioBreeding rat diabetes model is infected with Ljungan virus 10.1007/S00125-007-0659-3
Relationship Between Ljungan Virus Antibodies, HLA-DQ8, and Insulin Autoantibodies in Newly Diagnosed Type 1 Diabetes Children 10.1089/VIM.2013.0008
Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents 10.1016/J.DIABRES.2013.03.003
Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes 10.1111/J.1399-5448.2012.00916.X
The environment and the origins of islet autoimmunity and Type 1 diabetes 10.1111/DME.12099
The BioBreeding rat diabetes model is infected with Ljungan virus (vol 50, pg 1559, 2007) 10.1007/S00125-007-0780-3
Immune therapy in type 1 diabetes mellitus 10.1038/NRENDO.2012.237
Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes 10.1530/JOE-12-0385
RISK FOR DEVELOPING TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS AND THE PRESENCE OF ISLET 64K ANTIBODIES 10.1007/BF00401518
Antigenicity and Epitope Specificity of ZnT8 Autoantibodies in Type 1 Diabetes 10.1111/SJI.12008
Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season 10.1002/DMRR.2365
Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes 10.1038/GENE.2012.44
Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans 10.1101/GR.134304.111
Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings 10.1016/J.HUMIMM.2012.07.337
Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study 10.2337/DB11-1659
Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes 10.1111/J.1399-5448.2012.00857.X
Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy 10.1089/VIM.2012.0022
Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years 10.1016/J.DIABRES.2011.12.013
Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden 10.1038/IJO.2011.122
HTR1A a Novel Type 1 Diabetes Susceptibility Gene on Chromosome 5p13-q13 10.1371/JOURNAL.PONE.0035439
BLUEPRINT to decode the epigenetic signature written in blood 10.1038/NBT.2153
C-peptide in the classification of diabetes in children and adolescents 10.1111/J.1399-5448.2011.00807.X
HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus 10.1016/J.DIABRES.2011.10.037
Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM 10.1007/BF00400659
High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes 10.1016/J.HUMIMM.2011.10.019
Serum metabolite signature predicts the acute onset of diabetes in spontaneously diabetic congenic BB rats 10.1007/S11306-011-0278-3
Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes 10.3109/08916934.2011.576724
Diabetes-associated HLA genotypes affect birthweight in the general population 10.1007/S00125-005-1813-4
Early-Pregnancy Cytokines in Mothers to Children Developing Multiple, Persistent Islet Autoantibodies, Type 1 Diabetes, or Both Before 7 Years of Age 10.1111/J.1600-0897.2011.01057.X
DIFFERENTIAL DETECTION OF RAT ISLET AND BRAIN GLUTAMIC-ACID DECARBOXYLASE (GAD) ISOFORMS WITH SEQUENCE-SPECIFIC PEPTIDE ANTIBODIES 10.1177/43.1.7822765
Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics 10.1038/JP.2011.26
The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants 10.1111/J.1399-5448.2011.00774.X
BB rat Gimap gene expression in sorted lymphoid T and B cells 10.1016/J.LFS.2011.08.016
A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes 10.1016/J.JIM.2011.06.011
Editorial Comment on type 1 diabetes and antigen-specific immunotherapy 10.1111/J.1365-2796.2011.02412.X
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus 10.2337/DC10-0415
Vaccination against type 1 diabetes 10.1111/J.1365-2796.2011.02386.X
Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus 10.1373/CLINCHEM.2011.163634
Position Statement Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus 10.2337/DC11-9997
Sustained glucagon-like peptide 1 expression from encapsulated transduced cells to treat obese diabetic rats 10.1016/J.JBIOSC.2010.12.008
HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus and the Risk of Retinopathy 15 Years Later 10.1371/JOURNAL.PONE.0017569
Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes 10.3109/08916934.2010.509120
High-titer GAD65 autoantibodies detected in adult diabetes patients using a high efficiency expression vector and cold GAD65 displacement 10.3109/08916934.2010.482117
Danish children born with glutamic acid decarboxylase-65 and islet antigen-2 autoantibodies at birth had an increased risk to develop type 1 diabetes 10.1530/EJE-10-0792
Seroconversion to islet autoantibodies between early pregnancy and delivery in non-diabetic mothers 10.1016/J.JRI.2010.10.002
Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates 10.1016/J.MOLIMM.2010.08.005
Does immune-tolerance treatment with alum-formulated GAD65 protect insulin-production in the pancreatic islet beta-cells? 10.4161/HV.7.1.14488
ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset 10.3109/08916930903555927
Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies 10.1111/J.1399-5448.2010.00637.X
Changes in GAD65Ab-Specific Antiidiotypic Antibody Levels Correlate with Changes in C-Peptide Levels and Progression to Islet Cell Autoimmunity 10.1210/JC.2010-0785
Identification of a Serum-Induced Transcriptional Signature Associated With Type 1 Diabetes in the BioBreeding Rat 10.2337/DB10-0372
Altered natural killer (NK) cell frequency and phenotype in latent autoimmune diabetes in adults (LADA) prior to insulin deficiency 10.1111/J.1365-2249.2010.04114.X
The association between the PTPN22 1858C > T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies 10.1038/GENE.2010.12
Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model 10.1007/S00125-006-0339-8
Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1 10.1002/JGM.1466
Comparison of Radioimmunoprecipitation With Luciferase Immunoprecipitation for Autoantibodies to GAD65 and IA-2 beta 10.2337/DC09-1938
Differential effects of leptin receptor mutation on male and female BBDR.(Gimap5-/Gimap5-) spontaneously diabetic rats 10.1152/PHYSIOLGENOMICS.00186.2009
ISLET CELL CYTOPLASMIC ANTIBODIES (ICA) IN DIABETES AND DISORDERS OF GLUCOSE-TOLERANCE 10.1111/J.1464-5491.1991.TB02118.X
Immunology of beta-Cell Destruction 10.1007/978-90-481-3271-3_24
Comparison of three assays for the detection of GAD65Ab-specific anti-idiotypic antibodies 10.1016/J.JIM.2009.09.004
Low agreement between radio binding assays in analyzing glutamic acid decarboxylase (GAD65Ab) autoantibodies in patients classified with type 2 diabetes 10.1080/08916930902911720
GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes 10.1007/S00125-009-1371-2
Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene 10.1152/PHYSIOLGENOMICS.00015.2009
Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus 10.1007/S00335-009-9172-Y
Sequence Variation and Expression of the Gimap Gene Family in the BB Rat 10.1155/2009/835650
The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes 10.1111/J.1744-313X.2008.00802.X
Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5 10.1182/BLOOD-2008-03-146555
Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk 10.1007/S00592-008-0048-5
Treatment of diabetic rats with encapsulated islets 10.1111/J.1582-4934.2008.00322.X
A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2 10.2337/DC08-0286
Annual screening detects celiac disease in children with type 1 diabetes 10.1111/J.1399-5448.2008.00367.X
Increased lipid oxidation heralds diabetes onset in DR.lyp/lyp rats 10.1055/S-2008-1062713
Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens 10.1016/J.CLIM.2008.01.018
HLA class II alleles specify phenotypes of ketosis-prone diabetes 10.2337/DC07-1971
Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein 10.1016/J.JIM.2008.02.006
Cutaneous microvascular dysfunction is associated with human leukocyte antigen-DQ in youths with type 1 diabetes 10.1203/PDR.0B013E318165BFD4
Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birth 10.1111/J.1399-5448.2007.00349.X
Gene candidates for the diabetes susceptibility locus Iddm 14 identified in inbred and recombinant congenic rats 10.1016/J.CLIM.2008.03.306
GAD65 Autoimmunity-Clinical Studies 10.1016/S0065-2776(08)00803-1
Risk Conferred by HLA-DR and DQ for Type 1 Diabetes in 0-35-Year Age Group in Sweden 10.1196/ANNALS.1447.061
Type 1 Diabetes Onset with Ketoacidosis and Suspected Cerebral Edema 10.1007/978-1-60327-103-5_35
En Passant Diagnosis of Type 1 Diabetes in Infancy 10.1007/978-1-60327-103-5_36
Type 1 Diabetes and Comorbidity of Addison's Disease 10.1007/978-1-60327-103-5_37
Islet Cell Autoantigens 10.1007/978-1-59745-517-6_11
Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age 10.1155/2008/271958
Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study 10.1111/J.1365-3016.2007.00846.X
Atherogenic vascular and lipid phenotypes in young patients with Type 1 diabetes are associated with diabetes high-risk HLA genotype 10.1152/AJPHEART.00795.2007
Enitope analysis of GAD65 binding in both cord blood and at the time of clinical diagnosis of childhood type 1 diabetes 10.1055/S-2007-992128
Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat 10.1189/JLB.0407213
IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5 10.1038/SJ.GENE.6364413
Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis 10.1111/J.1399-0039.2007.00867.X
The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children 10.1111/J.1399-5448.2007.00245.X
Decreased core temperature and Increased beta(3)-Adrenergic sensitivity in diabetes-prone BB rats 10.1089/DIA.2006.0036
Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjects 10.1016/J.JDIACOMP.2006.01.004
GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination 10.1111/J.1464-5491.2007.02091.X
Antibodies to GAD65 and peripheral nerve function in the DCCT 10.1016/J.JNEUROIM.2007.01.009
Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels 10.1055/S-2007-970574
Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations 10.1155/2007/574363
Evidence for immunological priming and increased frequency of CD4(+) CD25(+) cord blood T cells in children born to mothers with type 1 diabetes 10.1111/J.1365-2249.2006.03243.X
Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats 10.2337/DB06-0715
Accuracy and predictive value of classification schemes for ketosis-prone diabetes 10.2337/DC06-0749
Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice 10.1016/J.CLIM.2006.08.002
Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden 10.1086/507876
Islet autoantibodies in cord blood from children who developed Type I (insulin-dependent) diabetes mellitus before 15 years of age 10.1007/S001250051137
Glucose-regulated insulin expression in diabetic rats 10.1089/104303401750061195
Reduction of tissue transglutaminase autoantibody levels by gluten-free diet is associated with changes in subsets of peripheral blood lymphocytes in children with newly diagnosed coeliac disease 10.1111/J.1365-2249.2006.03036.X
Increased galanin expression in the celiac ganglion of BB diabetic rats 10.1016/J.NPEP.2005.08.005
Association of Foxp3 polymorphism with GAD65 autoantibodies in type 1 diabetes 10.1016/J.CLIM.2006.04.454
MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus 10.1196/ANNALS.1375.036
TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial 10.1196/ANNALS.1375.049
Cord blood islet autoantibodies are related to stress in the mother during pregnancy 10.1196/ANNALS.1375.053
DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats 10.1016/J.JAUT.2005.06.003
Autoantibodies in diabetes 10.2337/DIABETES.54.SUPPL_2.S52
Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age 10.1111/J.1464-5491.2005.01694.X
Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat 10.1016/J.JAUT.2005.05.002
Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background 10.1016/J.JAUT.2005.03.008
Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes 10.1016/J.JDIACOMP.2004.12.003
Epitope analysis of insulin autoantibodies using recombinant Fab 10.1111/J.1365-2249.2005.02802.X
GLUCAGON AND INSULIN RELEASE FROM ALLOGRAFTED CANINE PANCREAS 10.1159/000127803
The HLA component of type I diabetes 10.1086/302854
Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat 10.4049/JIMMUNOL.173.11.6993
Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes 10.1210/JC.2004-0864
Genetic and perinatal factors as risk for childhood type 1 diabetes 10.1002/DMRR.506
Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat 10.1152/PHYSIOLGENOMICS.00126.2004
A high prevalence of organ-specific autoimmunity in patients with bipolar disorder 10.1016/J.BIOPSYCH.2004.07.003
Conformation-dependent GAD65 autoantibodies in diabetes 10.1007/S00125-004-1495-3
Type I diabetes as a model for prediction and diagnosis 10.1080/08916930410001726012
HLA-DRB1,-DQA1, and-DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for severe retinopathy in younger Type 1 diabetic patients 10.1016/S1056-8727(03)00040-0
Systematic screening of potential beta-cell imaging agents 10.1016/J.BBRC.2003.12.182
Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy 10.1152/AJPENDO.00136.2003
Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat 10.1016/S0896-8411(03)00138-0
Studies on the biosynthesis of the other peptide hormones of the rat islets of Langerhans 10.1042/BST0080411
Ketosis-prone diabetes: Dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes 10.1210/JC.2003-030180
Follow-up report on the diagnosis of diabetes mellitus 10.2337/DIACLIN.22.2.71
Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes 10.1210/JC.2002-021529
Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay 10.1016/S0168-1656(03)00125-1
High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INSVNTR 10.1046/J.1365-2796.2003.01115.X
Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden 10.1016/S0198-8859(03)00035-1
Animal models of endocrine/organ-specific autoimmune diseases: do they really help us to understand human autoimmunity? 10.1007/S00281-002-0110-2
Macrophages from high-risk HLA-DQBI*0201/*0302 type 1 diabetes mellitus patients are hypersensitive to lipopolysaccharide stimulation 10.1046/J.1365-3083.2002.01150.X
Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats 10.2337/DIABETES.51.10.2997
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (lan)-related gene 10.1101/GR.412702
ISLET CELL AND OTHER ORGAN-SPECIFIC AUTOANTIBODIES IN ALL CHILDREN DEVELOPING TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS IN SWEDEN DURING ONE YEAR AND IN MATCHED CONTROL CHILDREN 10.1007/BF00277264
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes 10.2337/DIABETES.51.5.1346
Protein-free diets do not protect high-incidence diabetes-prone BioBreeding rats from diabetes 10.1053/META.2002.31979
Controlling the controls: GAD65 autoreactive T cells in type 1 diabetes 10.1172/JCI200215381
GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families 10.1016/S0168-8227(01)00348-5
The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats 10.1111/J.1574-695X.2002.TB00555.X
Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset 10.1006/JAUT.2001.0564
Tissue transglutaminase autoantibodies and human leucocyte antigen in Down's syndrome patients with coeliac disease 10.1080/080352502753457914
HLA and glutamic acid decarboxylase in human insulin-dependent diabetes mellitus 10.1002/(SICI)1096-9136(199603)13:3<209::AID-DIA39>3.0.CO;2-2
Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients 10.2337/DIABETES.48.3.484
Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding 10.1016/S0014-5793(00)02429-7
SPECIFIC HUMAN PANCREATIC-ISLET CELL-PROTEINS RECOGNIZED BY ANTIBODIES IN DIABETIC CHILDREN 10.1111/J.1749-6632.1982.TB36124.X
Streptozotocin induced diabetes in minipig: A case report of a possible model for type 1 diabetes? 10.1080/0891693021000010703
Islet cell autoantibodies in cord blood from children with blood group incompatibility or hyperbilirubinemia 10.1080/0891693031000073109
Islet autoantibodies in cord blood from patients who developed type 1 diabetes mellitus at 15-30 years of age 10.1080/089193031000141040
SEQUENTIAL INJECTION IMMUNOASSAY UTILIZING IMMUNOMAGNETIC BEADS 10.1021/AC00037A010
Context and disease when disease risk is low: the case of type 1 diabetes in Sweden 10.1136/JECH.2008.083667
SPONTANEOUS INVITRO IMMUNOGLOBULIN SECRETION AT THE DIAGNOSIS OF INSULIN-DEPENDENT DIABETES 10.1530/ACTA.0.1050521
LOCUS-SPECIFIC DETECTION OF HLA-DQ AND HLA-DR ANTIGENS BY ANTIBODIES AGAINST SYNTHETIC N-TERMINAL OCTAPEPTIDES OF THE BETA-CHAIN 10.1016/0014-5793(85)81050-4
MULTIPLE GROWTH HORMONE-BINDING PROTEINS ARE EXPRESSED ON INSULIN-PRODUCING CELLS 10.1210/MEND-3-8-1173
PATHOGENESIS OF INSULIN-DEPENDENT DIABETES-MELLITUS 10.1016/S0950-351X(95)80803-5
Tolerance to kidney allograft transplanted into Type I diabetic patients persists after in vivo challenge with pancreatic islet allografts that express repeated mismatches 10.1007/S001250051456
IMMUNOLOGY AND DIABETES WORKSHOPS - REPORT OF THE 2ND INTERNATIONAL WORKSHOP ON THE STANDARDIZATION OF CYTOPLASMIC ISLET CELL ANTIBODIES - SUMMARY OF A WORKSHOP ORGANIZED BY THE IMMUNOLOGY-AND-DIABETES-WORKSHOPS-COMMITTEE, SUPPORTED IN PART BY THE JUVENILE-DIABETES-FOUNDATION-INTERNATIONAL, AND HELD AT THE SCIENCE AT SEA-1987 MEETING IN PERTH, WESTERN-AUSTRALIA, FROM 20-22 JANUARY 1987T 10.1007/BF00270427
ISLET CELL ANTIBODIES AND FASTING C-PEPTIDE PREDICT INSULIN REQUIREMENT AT DIAGNOSIS OF DIABETES-MELLITUS 10.1007/BF00404145
Influence of heredity on the appearance of islet autoantibodies in cordblood from children developing Type I diabetes before 15 years of age 10.1007/PL00002932
GAD65-specific antoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65 10.2337/DIABETES.49.10.1621
The World Health Organization International Collaborative Study for Islet Cell Antibodies 10.1007/S001250051524
Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression 10.1126/scitranslmed.abd5666
Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes 10.1099/jgv.0.001602
Etiology of Autoimmune Islet Disease: Timing Is Everything 10.2337/dbi18-0034
Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study 10.1007/s00125-021-05514-3
Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample 10.1007/s00125-021-05523-2
Philippe Froguel
Froguel Philippe
ORCID: 0000-0003-2972-0784
Transmission of Type 2 diabetes to sons and daughters: the D.E.S.I.R. cohort. 10.1111/dme.13446
Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis 10.1183/13993003.02314-2016
Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles 10.1371/journal.pone.0179583
Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis 10.1371/journal.pone.0176396
Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults 10.1371/journal.pgen.1006528
Early metabolic markers identify potential targets for the prevention of type 2 diabetes 10.1007/s00125-017-4325-0
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. 10.2337/db16-1253
Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion. 10.1016/j.molmet.2017.03.011
8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3-5 October 2016. 10.1515/dmpt-2017-0011
Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children 10.1155/2017/2432957
Erratum: Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population. 10.1002/oby.21803
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 10.1038/ncomms14977
The case for too little melatonin signalling in increased diabetes risk. 10.1007/s00125-017-4255-x
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 10.2337/db16-1329
Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach. 10.1186/s12916-017-0784-x
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. 10.1016/j.ajhg.2017.01.011
Hepatic DPP4 DNA Methylation Associates With Fatty Liver 10.2337/db15-1716
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. 10.1016/S2213-8587(16)30396-5
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. 10.1073/pnas.1611243113
Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. 10.1016/j.molmet.2016.09.011
Genome-wide analysis identifies 12 loci influencing human reproductive behavior. 10.1038/ng.3698
Detection of human adaptation during the past 2000 years. 10.1126/science.aag0776
Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. 10.1016/j.molmet.2016.08.011
Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL. 10.1371/journal.pone.0163046
The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm. 10.1016/j.cmet.2016.08.015
Associations Between Type 2 Diabetes-Related Genetic Scores and Metabolic Traits, in Obese and Normal-Weight Youths. 10.1210/jc.2016-2432
Comment on Beltrand et al. Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations. Diabetes Care 2015;38:2033-2041. 10.2337/dc15-2703
Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. 10.1002/oby.21593
[Not Available]. 10.2515/therapie/2014230
Genomic insights into the origin of farming in the ancient Near East. 10.1038/nature19310
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 10.1038/ng.3667
The genetic architecture of type 2 diabetes. 10.1038/nature18642
Monogenic diabetes: Implementation of translational genomic research towards precision medicine. 10.1111/1753-0407.12446
DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes. 10.2337/db16-0014
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 10.1371/journal.pgen.1006166
Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis 10.1371/journal.pone.0158051
Eating Behavior, Low-Frequency Functional Mutations in the Melanocortin-4 Receptor (MC4R) Gene, and Outcomes of Bariatric Operations: A 6-Year Prospective Study 10.2337/dc16-0115
Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study. 10.1016/j.numecd.2016.04.010
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. 10.1038/mp.2016.71
KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response 10.1016/j.celrep.2016.03.079
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. 10.1093/hmg/ddw048
Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity. 10.4137/IJTR.S11717
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk 10.1038/ncomms10495
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function 10.1038/ncomms10023
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index 10.1093/hmg/ddv472
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci 10.1038/ng.3437
What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity? 10.1371/journal.pone.0143373
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 10.1371/journal.pgen.1005378
Genetic association analyses highlight biological pathways underlying mitral valve prolapse 10.1038/ng.3383
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation 10.1002/oby.21199
Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population 10.1002/oby.21142
Directional dominance on stature and cognition in diverse human populations 10.1038/nature14618
A girl with incomplete Prader-Willi syndrome and negative MS-PCR, found to have mosaic maternal UPD-15 at SNP array 10.1002/ajmg.a.37222
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study 10.1016/S2213-8587(15)00127-8
The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis 10.1007/s00125-015-3659-8
Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels 10.1136/jmedgenet-2015-103065
Association of gene variants with susceptibility to type 2 diabetes among Omanis 10.4239/wjd.v6.i2.358
Genetic studies of body mass index yield new insights for obesity biology 10.1038/nature14177
New genetic loci link adipose and insulin biology to body fat distribution 10.1038/nature14132
Rare and Common Genetic Events in Type 2 Diabetes: What Should Biologists Know? 10.1016/j.cmet.2014.12.020
Genetic Determinants of Leucocyte Telomere Length in Children: a Neglected and Challenging Field 10.1111/ppe.12173
Biological interpretation of genome-wide association studies using predicted gene functions 10.1038/ncomms6890
RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human beta Cells 10.1016/j.celrep.2014.11.010
Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children 10.1007/s00125-014-3441-3
Defining the role of common variation in the genomic and biological architecture of adult human height 10.1038/ng.3097
Identification of Two Novel Loss-of-Function SIM1 Mutations in Two Overweight Children with Developmental Delay 10.1002/oby.20886
Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients 10.1016/j.soard.2013.12.016
Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes 10.1371/journal.pgen.1004517
Fine-scale human genetic structure in Western France 10.1038/ejhg.2014.175
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index 10.1371/journal.pgen.1004508
Placental antiangiogenic prolactin fragments are increased in human and rat maternal diabetes 10.1016/j.bbadis.2014.06.026
Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study 10.1007/s00125-014-3277-x
A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity 10.1038/ijo.2014.96
Common Genetic Variants and Risk of Brain Injury After Preterm Birth 10.1542/peds.2013-3011
Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study 10.1371/journal.pmed.1001647
Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2 10.1042/BJ20131618
Role of the Unfolded Protein Response in beta Cell Compensation and Failure during Diabetes 10.1155/2014/795171
Quality control and conduct of genome-wide association meta-analyses 10.1038/nprot.2014.071
Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice 10.1371/journal.pone.0092684
Multi-ethnic fine-mapping of 14 central adiposity loci 10.1093/hmg/ddu183
A Central Role for GRB10 in Regulation of Islet Function in Man 10.1371/journal.pgen.1004235
Low copy number of the salivary amylase gene predisposes to obesity 10.1038/ng.2939
Comment On: Valette et al. Melanocortin-4 Receptor Mutations and Polymorphisms Do Not Affect Weight Loss after Bariatric Surgery. PLOS ONE 2012; 7(11):E48221 10.1371/journal.pone.0093324
CDKN2B expression and subcutaneous adipose tissue expandability: Possible influence of the 9p21 atherosclerosis locus 10.1016/j.bbrc.2014.03.075
Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions 10.1155/2014/873679
Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study 10.1016/S2213-8587(13)70059-7
Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes 10.1007/s12015-014-9503-6
Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4 alpha at the protein level 10.1007/s00125-013-3154-z
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility 10.1038/ng.2897
Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. 10.1155/2013/139239
Direct Estimates of Natural Selection in Iberia Indicate Calcium Absorption Was Not the Only Driver of Lactase Persistence in Europe 10.1093/molbev/msu049
Novel LEPR Mutations in Obese Pakistani Children Identified by PCR-Based Enrichment and Next Generation Sequencing 10.1002/oby.20667
Leveraging Cross- Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms 10.1016/j.cell.2013.10.058
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity 10.2337/db13-0949
Coffee and tea consumption, genotype- based CYP1A2 and NAT2 activity and colorectal cancer risk- Results from the EPIC cohort study 10.1002/ijc.28655
Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates 10.1371/journal.pgen.1003919
Peroxisome Proliferator-activated Receptor gamma Regulates Genes Involved in Insulin/Insulin-like Growth Factor Signaling and Lipid Metabolism during Adipogenesis through Functionally Distinct Enhancer Classes 10.1074/jbc.M113.526996
The SH2B1 obesity locus and abnormal glucose homeostasis: Lack of evidence for association from a meta-analysis in individuals of European ancestry 10.1016/j.numecd.2013.05.001
Highly Sensitive Diagnosis of 43 Monogenic Forms of Diabetes or Obesity Through One-Step PCR-Based Enrichment in Combination With Next-Generation Sequencing 10.2337/dc13-0698
Meal Frequencies Modify the Effect of Common Genetic Variants on Body Mass Index in Adolescents of the Northern Finland Birth Cohort 1986 10.1371/journal.pone.0073802
GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm 10.1371/journal.pgen.1003657
Genome-wide association study identifies three novel loci for type 2 diabetes 10.1093/hmg/ddt399
Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts 10.1007/s00125-013-3021-y
Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck 10.1186/gb-2013-14-7-309
Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics 10.1016/j.ajhg.2013.06.011
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death 10.1038/ng.2712
Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications 10.1038/ng.2700
Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes 10.1186/1742-4682-10-45
Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore? 10.1371/journal.pone.0067650
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features 10.1172/JCI68035
Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects 10.1007/s12020-013-0009-9
Evidence for tuning adipocytes ICER levels for obesity care. 10.4161/adip.20000
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits 10.1371/journal.pgen.1003500
Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations 10.1007/s00109-013-1027-z
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders 10.1038/ng.2610
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture 10.1038/ng.2606
Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci 10.1101/gr.155127.113
Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family 10.1016/j.diabet.2013.02.007
Rare Genomic Structural Variants in Complex Disease: Lessons from the Replication of Associations with Obesity 10.1371/journal.pone.0058048
From obesity genetics to the future of personalized obesity therapy 10.1038/nrendo.2013.57
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity,Weight loss and resting metabolic rate 10.1016/j.bbrc.2013.03.031
Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity 10.1002/oby.20443
Integration of clinical data with a genome-scale metabolic model of the human adipocyte 10.1038/msb.2013.5
What Is the Contribution of Two Genetic Variants Regulating VEGF Levels to Type 2 Diabetes Risk and to Microvascular Complications? 10.1371/journal.pone.0055921
Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels 10.1007/s00125-013-2875-3
Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts 10.1371/journal.pmed.1001383
Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children 10.1186/1471-2350-14-21
Blood Microbiota Dysbiosis Is Associated with the Onset of Cardiovascular Events in a Large General Population: The DESIR Study 10.1371/journal.pone.0054461
Improved Protocol For Laser Microdissection Of Human Pancreatic Islets From Surgical Specimens 10.3791/50231
Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India 10.2337/db12-1077
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 10.1038/ng.2500
Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men 10.1210/jc.2012-2764
Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes 10.1007/s00125-012-2794-8
Seventy-five genetic loci influencing the human red blood cell 10.1038/nature11677
Estimation of Newborn Risk for Child or Adolescent Obesity: Lessons from Longitudinal Birth Cohorts 10.1371/journal.pone.0049919
Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21 10.2337/db12-0406/-/DC1
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism 10.1038/ng.2477
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes 10.1007/s00125-012-2756-1
Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population 10.1038/ijo.2012.175
A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site 10.1182/blood-2012-01-401893
Response to comment on: Marquez et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes 2012;61:524-530. 10.2337/db12-0800
A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans 10.2337/db12-0454
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways 10.1038/ng.2385
TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals 10.1007/s00125-012-2660-8
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes 10.1038/ng.2383
GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes 10.1007/s00125-012-2645-7
Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms 10.1371/journal.pone.0040351
Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers 10.1093/nar/gks595
Whole-Exome Sequencing and High Throughput Genotyping Identified KCNJ11 as the Thirteenth MODY Gene 10.1371/journal.pone.0037423
Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits 10.2337/db11-1515
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases 10.1371/journal.pgen.1002741
The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size 10.1371/journal.pone.0038216
Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity 10.1371/journal.pone.0035810
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity 10.1093/hmg/dds187
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone 10.1152/ajpregu.00373.2011
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance 10.1038/ng.2274
Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women 10.1371/journal.pgen.1002695
The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis 10.1016/j.beem.2011.12.001
Circadian Gene Variants and Susceptibility to Type 2 Diabetes: A Pilot Study 10.1371/journal.pone.0032670
A genome-wide association meta-analysis identifies new childhood obesity loci 10.1038/ng.2247
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals 10.1371/journal.pgen.1002607
High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families 10.1016/j.ymgme.2012.03.001
European genetic variants associated with type 2 diabetes in North African Arabs 10.1016/j.diabet.2012.02.003
Loss-of-Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population 10.1038/oby.2012.77
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations 10.1093/hmg/dds113
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels 10.2337/db11-0973
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis 10.1038/ng.2232
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron 10.1038/ng.2218
A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels 10.1371/journal.pone.0032327
Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations 10.1371/journal.pgen.1002490
Multicohort Genomewide Association Study Reveals a New Signal of Protection Against HIV-1 Acquisition 10.1093/infdis/jis028
Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study 10.1111/j.1365-2796.2012.02532.x
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma 10.1038/ng.1085
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human 10.1038/nature10798
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes 10.1038/ng.1053
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans 10.1371/journal.pone.0029202
Parent-Offspring Correlations in Pedometer-Assessed Physical Activity 10.1371/journal.pone.0029195
Clinical and Metabolic Features of Adult-Onset Diabetes Caused by ABCC8 Mutations 10.2337/dc11-1469
Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk 10.2337/db11-0728
Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity 10.2337/db11-0305
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians 10.1038/ng.1019
New gene functions in megakaryopoiesis and platelet formation 10.1038/nature10659
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children 10.1371/journal.pmed.1001116
Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion 10.1074/jbc.M111.254995
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma 10.1038/ng.970
Low Water Intake and Risk for New-Onset Hyperglycemia 10.2337/dc11-0652
Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene 10.1371/journal.pone.0025470
The Lin28/let-7 Axis Regulates Glucose Metabolism 10.1016/j.cell.2011.08.033
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus 10.1038/nature10406
Effects of Genetic Susceptibility for Type 2 Diabetes on the Evolution of Glucose Homeostasis Traits Before and After Diabetes Diagnosis Data From the DESIR Study 10.2337/db10-1442
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes 10.2337/db11-0415
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci 10.1038/ng.921
ITIH-5 Expression in Human Adipose Tissue Is Increased in Obesity 10.1038/oby.2011.268
Characterization of the human SLC30A8 promoter and intronic enhancer 10.1530/JME-11-0055
A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes 10.1007/s00125-011-2261-y
Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes 10.1186/1471-2350-12-99
Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity 10.1038/oby.2011.200
Systems medicine and integrated care to combat chronic noncommunicable diseases 10.1186/gm259
Common Variants in FTO, MC4R, TMEM18, PRL, AIF1 and PCSK1 Show Evidence of Association With Adult Obesity in the Greek Population 10.1038/oby.2011.177
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study 10.1007/s00125-011-2182-9
Number of children and change in markers of metabolic health over 9-years in men and women. Data from the DESIR study 10.1016/j.diabet.2011.04.006
Accurate Single-Nucleotide Polymorphism Allele Assignment in Trisomic or Duplicated Regions by Using a Single Base-Extension Assay with MALDI-TOF Mass Spectrometry 10.1373/clinchem.2010.159558
Disruption of a Novel Kruppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus 10.1074/jbc.M110.215822
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes 10.1038/ng.833
famCNV: copy number variant association for quantitative traits in families 10.1093/bioinformatics/btr264
Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations 10.1038/ijo.2011.86
Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study 10.1038/ijo.2011.91
Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children 10.2337/db10-1575
Chromosome 19p13.3 Deletion in a Patient With Macrocephaly, Obesity, Mental Retardation, and Behavior Problems 10.1002/ajmg.a.33986
Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway 10.1074/jbc.M111.224857
Dairy Consumption and the Incidence of Hyperglycemia and the Metabolic Syndrome Results from a French prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) 10.2337/dc10-1772
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits 10.1371/journal.pgen.1001324
Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue 10.1038/ijo.2011.22
Metabolic health, obesity and 9-year incidence of peripheral arterial disease: The DESIR study 10.1016/j.atherosclerosis.2011.02.032
Investigation of the HIN200 Locus in UK SLE Families Identifies Novel Copy Number Variants 10.1111/j.1469-1809.2011.00641.x
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease 10.1038/ng.782
Bio-Repository of DNA in stroke (BRAINS): A study protocol 10.1186/1471-2350-12-34
Childhood Obesity Is Associated with Shorter Leukocyte Telomere Length 10.1210/jc.2010-2924
TCF7L2 splice variants have distinct effects on beta-cell turnover and function 10.1093/hmg/ddr072
Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals 10.3945/ajcn.110.000828
Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations 10.1111/j.1399-5448.2010.00719.x
Influence of blood glucose on heart rate and cardiac autonomic function. The DESIR study 10.1111/j.1464-5491.2010.03222.x
Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine 10.1111/j.1749-6632.2010.05880.x
Screening Low-Frequency SNPS From Genome-Wide Association Study Reveals a New Risk Allele for Progression to AIDS 10.1097/QAI.0b013e318204982b
Molecular Diagnosis of Neonatal Diabetes Mellitus Using Next-Generation Sequencing of the Whole Exome 10.1371/journal.pone.0013630
Lack of Association of CD36 SNPs With Early Onset Obesity: A Meta-Analysis in 9,973 European Subjects 10.1038/oby.2010.226
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 10.1038/ng.686
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution 10.1038/ng.685
Mean and yearly changes in blood pressure with age in the metabolic syndrome: the DESIR study 10.1038/hr.2010.180
Common Variants at 10 Genomic Loci Influence Hemoglobin A(1C) Levels via Glycemic and Nonglycemic Pathways 10.2337/db10-0502
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B 10.1038/ng.660
Evaluation of A2BP1 as an Obesity Gene 10.2337/db09-1604
The emerging genetics of type 2 diabetes 10.1016/j.molmed.2010.06.004
Multiple-Cohort Genetic Association Study Reveals CXCR6 as a New Chemokine Receptor Involved in Long-Term Nonprogression to AIDS 10.1086/655782
Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies 10.2337/dc10.1150
Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the G6PC2 Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels 10.2337/db10-0389
Expression of the selenoprotein S (SELS) gene m subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors 10.1016/j.metabol.2010.05.011
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis 10.1038/ng.609
Monogenic forms of diabetes mellitus: an update. 10.1016/S1575-0922(09)73513-2
cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs 10.1038/NMETH.1466
Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups 10.1371/journal.pgen.1000916
Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study 10.1097/HJH.0b013e328338a901
Inferring combined CNV/SNP haplotypes from genotype data 10.1093/bioinformatics/btq157
Genetic Variability at the Six Transmembrane Protein of Prostate 2 Locus and the Metabolic Syndrome: The Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study 10.1210/jc.2010-0026
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight 10.1038/ng.567
Evidence for leptin receptor isoforms heteromerization at the cell surface 10.1016/j.febslet.2010.03.033
Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue 10.1155/2010/823486
MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans 10.2337/db09-1757
High Baseline Insulin Levels Associated With 6-Year Incident Observed Sleep Apnea 10.2337/dc09-1901
Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population 10.1038/jhg.2010.10
Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets 10.1016/j.ymgme.2010.01.001
Study of TNF alpha-308G/A and IL6-174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population 10.1016/j.clinbiochem.2010.01.008
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2 10.1038/nature08727
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk 10.1038/ng.520
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge 10.1038/ng.521
Analysis of the SIM1 Contribution to Polygenic Obesity in the French Population 10.1038/oby.2009.468
Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population 10.1159/000178157
TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet 10.3945/ajcn.2009.27947
PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women 10.1186/1471-2350-10-145
Parental origin of sequence variants associated with complex diseases 10.1038/nature08625
Insulin Gene Mutations Resulting in Early-Onset Diabetes: Marked Differences in Clinical Presentation, Metabolic Status, and Pathogenic Effect Through Endoplasmic Reticulum Retention 10.2337/db09-1091
Genome-wide association study identifies five loci associated with lung function 10.1038/ng.501
Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY) 10.2337/dc09-0681
Early Detrimental Metabolic Outcomes of rs17300539-A Allele of ADIPOQ Gene Despite Higher Adiponectinemia 10.1038/oby.2009.403
Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study 10.1038/oby.2009.377
Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? 10.1371/journal.pgen.1000694
The Imprinted Gene Neuronatin Is Regulated by Metabolic Status and Associated With Obesity 10.1038/oby.2009.361
MODY7 Gene, KLF11, Is a Novel p300-dependent Regulator of Pdx-1 (MODY4) Transcription in Pancreatic Islet beta Cells 10.1074/jbc.M109.028852
Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals 10.2337/db09-0703
Genomewide Association Study of a Rapid Progression Cohort Identifies New Susceptibility Alleles for AIDS (ANRS Genomewide Association Study 03) 10.1086/605892
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia 10.1038/ng.443
Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians 10.2337/db08-1805
Genetic Variant m HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control-Related Traits 10.2337/009-0652
Tenomodulin Is Highly Expressed in Adipose Tissue, Increased in Obesity, and Down-Regulated during Diet-Induced Weight Loss 10.1210/jc.2009-0292
Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations 10.1016/j.ajhg.2009.06.002
Improved donor/acceptor BRET couples for monitoring beta-arrestin recruitment to G protein-coupled receptors. 10.1002/biot.200900016
Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants 10.2337/db09-0551
The genetic contribution to non-syndromic human obesity 10.1038/nrg2594
A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism 10.1093/hmg/ddp263
The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes 10.1530/EJE-09-0122
Sex hormone-binding globulin predicts the incidence of hyperglycemia in women: interactions with adiponectin levels 10.1530/EJE-09-0202
Center Effect on Ankle-Brachial Index Measurement when Using the Reference Method (Doppler and Manometer): Results From a Large Cohort Study 10.1038/ajh.2009.78
Common Variation in SIM1 Is Reproducibly Associated With BMI in Pima Indians 10.2337/db09-0028
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study 10.1038/ijo.2009.59
Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q 10.2337/db09-0081
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects 10.1093/hmg/ddp169
Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study 10.1186/1471-2350-10-33
Regulation of carboxylesterase 1 (CES1) in human adipose tissue 10.1016/j.bbrc.2009.03.120
G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release Studies Involving 19,605 Europeans 10.2337/db08-1660
A Rare Variant in the Visfatin Gene (NAMPT/PBEF1) Is Associated With Protection From Obesity 10.1038/oby.2009.75
Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles - a cohort study 10.1186/1471-2350-10-27
Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease 10.1159/000184688
TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia 10.1016/j.patbio.2009.01.003
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease 10.1016/j.bbrc.2009.03.014
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations 10.1007/s00109-009-0451-6
Mutations in G6PC2 do not contribute to monogenic forms of early infancy diabetes and beta cell dysfunction 10.1007/s00125-009-1299-6
Evaluating the association of common APOA2 variants with type 2 diabetes 10.1186/1471-2350-10-13
Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans 10.1007/s00439-009-0626-9
Common genetic variation near MC4R is associated with eating behaviour patterns in European populations 10.1038/ijo.2008.279
Association Studies on Ghrelin and Ghrelin Receptor Gene Polymorphisms With Obesity 10.1038/oby.2008.589
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations 10.1038/ng.301
Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height 10.1530/EJE-08-0794
Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02) 10.1086/596067
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk 10.1038/ng.277
Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population 10.1016/j.diabet.2008.06.005
Is Obesity Our Genetic Legacy? 10.1210/jc.2008-1676
The Q121 Variant of ENPP1 May Protect From Childhood Overweight/obesity in the Italian Population 10.1038/oby.2008.470
Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose 10.1097/FPC.0b013e32831101ef
A Genetic Study of the Ghrelin and Growth Hormone Secretagogue Receptor (GHSR) Genes and Stature 10.1111/j.1469-1809.2008.00484.x
Small Deletion Variants Have Stable Breakpoints Commonly Associated with Alu Elements 10.1371/journal.pone.0003104
The FTO gene is associated with adulthood obesity in the Mexican population 10.1038/oby.2008.367
Predicting Diabetes: Clinical, Biological, and Genetic Approaches Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) 10.2337/dc08-0368
Effect of ENPP1/PC-1-K121Q and PPAR gamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population 10.1016/j.diabres.2008.06.004
Common nonsynonymous variants in PCSK1 confer risk of obesity 10.1038/ng.177
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees 10.2337/db08-0153
The common P446L polymorphism in GCAR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population 10.2337/db07-1807
Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: Potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant-1659G \textgreater C 10.1210/jc.2007-2504
The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies 10.1186/1471-2350-9-45
Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value 10.1371/journal.pone.0002031
Common variants near MC4R are associated with fat mass, weight and risk of obesity 10.1038/ng.140
Common genetic variation near MC4R is associated with waist circumference and insulin resistance 10.1038/ng.156
Inflammation is associated with a decrease of lipogenic factors in omental fat in women 10.1152/ajpregu.00926.2007
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels 10.1126/science.1156849
Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes 10.1210/er.2007-0024
Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2) 10.2337/dc07-2017
Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians 10.2337/db07-1789
Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans 10.1038/ejhg.2008.64
INS VNTR is not associated with childhood obesity in 1,023 families: A family-based study 10.1038/oby.2008.209
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations 10.1093/hmg/ddn089
Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids 10.1007/s00125-008-0973-4
A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults 10.2337/db07-1547
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population 10.1093/hmg/ddn070
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity 10.1093/hmg/ddn072
Evaluating the association of common PBX1 variants with type 2 diabetes 10.1186/1471-2350-9-14
Neonatal hyperglycaemia and abnormal development of the pancreas 10.1016/j.beem.2007.08.003
Effects of TCF7L2 polymorphisms on obesity in European populations 10.1038/oby.2007.77
Meta-analysis of 23 type 2 diabetes linkage studies from the international type 2 diabetes linkage analysis consortium 10.1159/000114164
Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: A report from the French ND (Neonatal Diabetes) Study Group 10.2337/db07-1358
Analysis of novel risk loci for type 2 diabetes in a general French population: the DESIR study 10.1007/s00109-007-0295-x
The EBPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: Evidence from an updated meta-analysis in 42,042 subjects 10.2337/db07-1336
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations 10.1007/s00125-007-0887-6
Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids 10.1007/s00125-007-0857-z
Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children 10.2337/db07-1273
Lack of association between the Pro(12)Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population 10.1007/s00592-007-0013-8
A single-nucleotide polymorphism in the p110 beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents 10.1210/jc.2007-1822
Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study (vol 272, pg 358, 2012) 10.1111/joim.12059
High prevalence of leptin and melanocotin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families (vol 106, pg 121, 2012) 10.1016/j.ymgme.2013.05.015
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron (vol 44, pg 458, 2012) 10.1038/ng0512-609
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (vol 42, pg 579, 2010) 10.1038/ng0411-388b
Response to the letter to the editor: "HIF-1 alpha protein rather than mRNA as a marker of hypoxia in adipose tissue in obesity," by Trayhurn et al. 10.1152/ajpregu.90722.2008
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (vol 42, pg 105, 2010) 10.1038/ng0510-464a
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia (vol 41, pg 1110, 2009) 10.1038/ng1009-1156c
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity 10.1073/pnas.0706671104
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population 10.1007/s00125-007-0827-5
Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online. 10.1002/humu.9511
Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes 10.1016/j.diabet.2007.06.002
40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. 10.1007/BF03375463
Neonatal diabetes: a disease linked to multiple mechanisms 10.1016/j.arcped.2007.08.010
ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study 10.1007/s00125-007-0787-9
Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity 10.1210/jc.2006-2316
Analysis of KLF transcription factor family gene variants in type 2 diabetes 10.1186/1471-2350-8-53
Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases 10.1093/hmg/ddm208
Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium 10.1086/520599
Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity 10.1186/1471-2350-8-44
TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population 10.1186/1471-2350-8-37
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TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis 10.1007/s00109-007-0203-4
Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes 10.1210/jc.2006-2657
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Coexistence in the same family of both focal and diffuse forms of hyperinsulinism 10.2337/dc06-2327
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Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits 10.2337/db06-1305
Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects 10.2337/db06-0930
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Two Caucasian families with the hepatocyte nuclear factor-1 alpha mutation Tyr218Cys 10.1055/s-2007-955099
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Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects 10.1007/s00125-006-0555-2
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No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases 10.1038/sj.ejhg.5201754
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No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects 10.1007/s00125-006-0505-z
Genotype-by-nutrient interactions assessed in European obese women - A case-only study 10.1007/s00394-006-0619-6
TCF7L2 variation predicts hyperglycentia incidence in a French general population - The Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study 10.2337/db06-0692
Epistasis between type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans 10.1111/j.1469-1809.2006.00289.x
Impact of a CART promoter genetic variation on plasma lipid profile in a general population 10.1016/j.ymgme.2006.08.012
Transcription factor TCF7L2 genetic study in the French population - Expression in human beta-cells and adipose tissue and strong association with type 2 diabetes 10.2337/db06-0474
Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians 10.2337/db06-0337
Genetics of obesity and the prediction of risk for health 10.1093/hmg/ddl215
Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q 10.2337/db06-0088
Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes 10.2337/db05-1369
Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women 10.1016/j.bbrc.2006.07.068
Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets 10.1371/journal.pctr.0010012
Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses 10.1016/j.ymgme.2006.05.013
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Hepatocyte nuclear factor-4 alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population 10.2337/db05-0620
Genetic basis of maturity-onset diabetes of the young 10.1016/j.ecl.2006.02.009
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Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women 10.1007/s00198-005-2022-1
Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1 10.1007/s00439-005-0036-6
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes 10.1038/ng1604
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Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes 10.1007/s00125-005-1806-3
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Implication of the Pro 12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population 10.1186/1471-2350-6-11
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Effect of common polymorphisms in the HNF4 alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population 10.1007/s00125-004-1665-3
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The EIF2AK3 gene region and type 1 diabetes in subjects from South India 10.1038/sj.gene.6364139
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Understanding the rising incidence of type 2 diabetes in adolescence 10.1136/adc.2003.028548
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A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population 10.1016/j.atherosclerosis.2003.12.029
GAD2 on chromosome 10p12 is a candidate gene for human obesity 10.1371/journal.pbio.0000068
Dissection of an inverted X(p21.3q27.1) chromosome associated with mental retardation 10.1159/000074167
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A meta-analysis of four European genome screens (GIFT consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes 10.1093/hmg/ddg195
PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population 10.1007/s00125-003-1170-0
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects 10.1038/nature01705
Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease 10.1038/sj.mp.4001344
Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians 10.1007/s00125-003-1083-y
Does the-11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families? 10.1007/s00125-003-1050-7
Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations 10.1093/hmg/ddg016
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis 10.1074/jbc.M209033200
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase 10.1038/nm788
Rare variants identified in the HNF-4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes 10.1007/s00125-002-0913-7
Genetic approaches to the molecular understanding of type 2 diabetes 10.1152/ajpendo.00099.2002
Disruption of adiponectin causes insulin resistance and neointimal formation. 10.1074/jbc.C200251200
Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children 10.1067/mpd.2001.116284
Nd2Ba2CaZn2Ti3O14.4: A new high dielectric constant oxide having a disordered (cubic) perovskite structure 10.1021/cm030043p
Let science speak for itself 10.1038/446850a
A Novel Rare Missense Variation of the Gene: Evidencesof Implication in Crohn's Disease. 10.3390/ijms20040835
A novel NEUROG3 mutation in neonatal diabetes associated with a neuro-intestinal syndrome 10.1111/pedi.12576
ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers 10.1002/lipd.12087
Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults 10.1016/j.ebiom.2018.10.066
Cdkn2a deficiency promotes adipose tissue browning 10.1016/j.molmet.2017.11.012
CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability 10.1016/j.molmet.2018.05.005
Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS 10.1371/journal.pone.0204861
Epigenome-wide association study of adiposity and future risk of obesity-related diseases 10.1038/s41366-018-0064-7
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes 10.2337/dc18-1032
Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation 10.1016/j.scr.2018.02.017
Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes 10.1002/oby.22064
High Prevalence of Rare Monogenic Forms of Obesity in Obese Guadeloupean Afro-Caribbean Children 10.1210/jc.2017-01956
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes 10.2337/db17-1539
Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose 10.3389/fgene.2018.00210
Loss-of-function mutations in ADCY3 cause monogenic severe obesity 10.1038/s41588-017-0023-6
MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue 10.1016/j.jacl.2018.07.009
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes 10.1007/s00125-017-4500-3
The unique clinical spectrum of maturity onset diabetes of the young type 3 10.1016/j.diabres.2017.10.024
Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling 10.1126/scisignal.aan6622
Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease 10.3389/fendo.2017.00304
Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? 10.1007/s11892-017-0957-1
Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect 10.1186/s13148-020-00858-w
Clustering for a better prediction of type 2 diabetes mellitus 10.1038/s41574-021-00475-4
Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran