luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria
Carolyn A. Brotherton Marnix H. Medema E. Peter Greenberg Pieter C. Dorrestein
mSystems, 2018
Everett Greenberg
Greenberg Everett
ORCID: 0000-0001-9474-8041
Positive Autoregulation of an Acyl-Homoserine Lactone Quorum-Sensing Circuit Synchronizes the Population Response 10.1128/mBio.01079-17
Gene Duplication in Pseudomonas aeruginosa Improves Growth on Adenosine 10.1128/JB.00261-17
Quorum sensing control of Type VI secretion factors restricts the proliferation of quorum-sensing mutants 10.7554/eLife.14712
Production of β-defensins by human airway epithelia 10.1073/pnas.95.25.14961
The involvement of cell-to-cell signals in the development of a bacterial biofilm 10.1126/science.280.5361.295
Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor 10.1073/pnas.1112398108
A new class of homoserine lactone quorum-sensing signals 10.1038/nature07088
Activity of abundant antimicrobials of the human airway 10.1165/ajrcmb.20.5.3572
Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis 10.1128/JB.00200-09
Isolation of the outer membrane and characterization of the major outer membrane protein from Spirochaeta aurantia 10.1128/jb.169.1.172-179.1987
A mutational analysis defines Vibrio fischeri LuxR binding sites 10.1128/JB.01443-07
Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid 10.1016/S0092-8674(00)81099-5
Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: A signaling mechanism involved in associations with higher organisms 10.1073/pnas.97.16.8789
Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases 10.1371/journal.pone.0112464
Tiny teamwork 10.1038/424134a
Intragenic suppression of a luxR mutation: Characterization of an autoinducer-independent LuxR 10.1016/0378-1097(95)00145-U
Microwave synthesis and evaluation of phenacylhomoserine lactones as anticancer compounds that minimally activate quorum sensing pathways in Pseudomonas Aeruginosa 10.1021/jm8015377
A distinct QscR regulon in the Pseudomonas aeruginosa quorum-sensing circuit 10.1128/JB.188.9.3365-3370.2006
Intragenic suppression of a luxR mutation: Characterization of an autoinducer‐independent LuxR 10.1111/j.1574-6968.1995.tb07563.x
The Pseudomonas aeruginosa RpoS regulon and its relationship to quorum sensing 10.1046/j.1365-2958.2003.03886.x
Pseudomonas aeruginosa Biofilms Exposed to Imipenem Exhibit Changes in Global Gene Expression and β-Lactamase and Alginate Production 10.1128/AAC.48.4.1175-1187.2004
RsaL provides quorum sensing homeostasis and functions as a global regulator of gene expression in Pseudomonas aeruginosa 10.1111/j.1365-2958.2007.06029.x
The genetic basis for the commitment to chronic versus acute infection in Pseudomonas aeruginosa 10.1016/j.molcel.2004.11.009
Early activation of quorum sensing in Pseudomonas aeruginosa reveals the architecture of a complex regulon 10.1186/1471-2164-8-287
Census and consensus in bacterial ecosystems: The LuxR-LuxI family of quorum-sensing transcriptional regulators 10.1146/annurev.micro.50.1.727
Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus 10.1128/JB.182.24.6921-6926.2000
The two-component response regulator PprB modulates quorum-sensing signal production and global gene expression in Pseudomonas aeruginosa (Molecular Microbiology (2005) 56, 5 (1287-1301) DOI: 10.1111/j.1365-2958.2005.04612.x) 10.1111/j.1365-2958.2008.06351.x
Quorum Sensing in Staphylococcus aureus Biofilms 10.1128/JB.186.6.1838-1850.2004
Pump up the versatility 10.1038/35023203
Quorum sensing in a methane-oxidizing bacterium 10.1128/JB.00773-16
A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases 10.1073/pnas.1313098110
Global analysis of the Burkholderia thailandensis quorum sensing-controlled regulon 10.1128/JB.01405-13
A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa 10.1073/pnas.92.5.1490
Bacterial biofilms: A common cause of persistent infections 10.1126/science.284.5418.1318
Generation of cell-to-cell signals in quorum sensing: Acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein 10.1073/pnas.93.18.9505
Contribution of the RsaL global regulator to Pseudomonas aeruginosa virulence and biofilm formation 10.1111/j.1574-6968.2009.01817.x
Spirochete chemotaxis, motility, and the structure of the spirochetal periplasmic flagella 10.1016/0923-2508(92)90117-7
AHL Signals Induce Rubrifacine Production in a bruI Mutant of Brenneria rubrifaciens 10.1094/PHYTO-04-11-0111
The influence of human respiratory epithelia on Pseudomonas aeruginosa gene expression 10.1016/j.micpath.2006.10.004
Reversible Acyl-Homoserine Lactone Binding to Purified Vibrio fischeri LuxR Protein 10.1128/JB.186.3.631-637.2004
LuxR homolog-independent gene regulation by acylhomoserine lactones in Pseudomonas aeruginosa 10.1073/pnas.1005909107
Global position analysis of the Pseudomonas aeruginosa quorum-sensing transcription factor LasR 10.1111/j.1365-2958.2009.06832.x
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression 10.1073/pnas.1200243109
Acyl-homoserine lactone binding to and stability of the orphan pseudomonas aeruginosa quorum-sensing signal receptor qscr 10.1128/JB.01041-10
Bacterial quorum sensing and metabolic incentives to cooperate 10.1126/science.1227289
Listening in on bacteria: Acyl-homoserine lactone signalling 10.1038/nrm907
Self perception in bacteria: Quorum sensing with acylated homoserine lactones 10.1016/S1369-5274(98)80009-X
Bactobolin A binds to a site on the 70S ribosome distinct from previously seen antibiotics 10.1016/j.jmb.2014.12.018
Identity gene expression in Proteus mirabilis 10.1128/JB.01167-10
Reversible signal binding by the Pseudomonas aeruginosa quorum-sensing signal receptor LasR 10.1128/mBio.00011-11
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa 10.1073/pnas.96.20.11229
Anaerobic p-coumarate degradation by Rhodopseudomonas palustris and identification of couR, a MarR repressor protein that binds p-coumaroyl coenzyme A 10.1128/JB.06817-11
Activity of the Rhodopseudomonas palustris p-coumaroyl-homoserine lactone-responsive transcription factor RpaR 10.1128/JB.01479-10
Quorum sensing signals in development of Pseudomonas aeruginosa biofilms 10.1016/S0076-6879(99)10005-3
Pseudomonas aeruginosa quorum sensing: A target for antipa thogenic drug discovery 10.1016/S0165-7208(02)80021-6
The two-component response regulator PprB modulates quorum-sensing signal production and global gene expression in Pseudomonas aeruginosa 10.1111/j.1365-2958.2005.04612.x
Gene expression in Pseudomonas aeruginosa biofilms 10.1038/35101627
Bacterial communication and group behavior 10.1172/JCI200320099
Increase in rhamnolipid synthesis under iron-limiting conditions influences surface motility and biofilm formation in Pseudomonas aeruginosa 10.1128/JB.01601-09
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes 10.1128/JB.183.19.5529-5534.2001
Induction of luciferase synthesis in Beneckea harveyi by other marine bacteria 10.1007/BF00409093
“Hot stuff”: The many uses of a radiolabel assay in detecting acyl-homoserine lactone quorum-sensing signals 10.1007/978-1-4939-7309-5_3
Linear osmoregulated periplasmic glucans are encoded by the opgGH locus of Pseudomonas aeruginosa 10.1099/mic.0.2007/008953-0
Vibrio parahaemolyticus ScrC modulates cyclic dimeric GMP regulation of gene expression relevant to growth on surfaces 10.1128/JB.01462-07
Regulation of gene expression by cell-to-cell communication: Acyl-homoserine lactone quorum sensing 10.1146/annurev.genet.35.102401.090913
Acyl-homoserine lactone quorum sensing: From evolution to application 10.1146/annurev-micro-092412-155635
Cross-species comparison of the Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei quorum-sensing regulons 10.1128/JB.01974-14
Conversion of the Vibrio fischeri transcriptional activator, LuxR, to a repressor 10.1128/JB.182.3.805-811.2000
Bactobolin resistance is conferred by mutations in the L2 ribosomal protein 10.1128/mBio.00499-12
Timing and localization of rhamnolipid synthesis gene expression in Pseudomonas aeruginosa biofilms 10.1128/JB.187.1.37-44.2005
Genetic determinants of self identity and social recognition in bacteria 10.1126/science.1160033
Spirochaeta halophila sp. n., a facultative anaerobe from a high-salinity pond 10.1007/BF00690227
Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm 10.1128/AEM.72.3.2064-2069.2006
Bacterial quorum sensing, cooperativity, and anticipation of stationary-phase stress 10.1073/pnas.1218092109
Woody Hastings: 65 years of fun 10.1073/pnas.1415972111
Rifampin as a selective agent for the enumeration and isolation of spirochetes from salt marsh habitats 10.1007/BF01567923
Territoriality in Proteus: Advertisement and aggression 10.1021/cr100051v
Sources of diversity in bactobolin biosynthesis by burkholderia thailandensis E264 10.1021/ol200922s
A network of networks: Quorum-sensing gene regulation in Pseudomonas aeruginosa 10.1016/j.ijmm.2006.01.036
Molecular basis for the substrate specificity of quorum signal synthases 10.1073/pnas.1705400114
Regulation of quorum sensing by RpoS in Pseudomonas aeruginosa 10.1128/JB.182.15.4356-4360.2000
Strain-dependent diversity in the Pseudomonas aeruginosa quorum-sensing regulon 10.1073/pnas.1214128109
Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes 10.1073/pnas.91.1.197
Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen 10.1128/AAC.00665-06
Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: A transcriptome analysis 10.1128/JB.185.7.2066-2079.2003
Cell-to-cell communication in Escherichia coli and Salmonella typhimurium: They may be talking, but who's listening? 10.1073/pnas.95.12.6571
The polarity of myxobacterial gliding is regulated by direct interactions between the gliding motors and the Ras homolog MglA 10.1073/pnas.1421073112
Quorum sensing and policing of Pseudomonas aeruginosa social cheaters 10.1073/pnas.1500704112
Synergistic binding of the Vibrio fischeri LuxR transcriptional activator domain and RNA polymerase to the lux promoter region 10.1073/pnas.91.26.12619
Cell-to-cell signaling in the symbiotic nitrogen-fixing bacterium Rhizobium leguminosarum: Autoinduction of a stationary phase and rhizosphere-expressed genes 10.1128/jb.178.2.372-376.1996
Synthesis of N‐[3‐OXO‐(4,5‐3H2)‐hexanoyl] homoserine lactone: Biologically active tritium‐labelled vibrio fischeri autinducer 10.1002/jlcr.2580220411
Putative exopolysaccharide synthesis genes influence Pseudomonas aeruginosa biofilm development 10.1128/JB.186.14.4449-4456.2004
An evolving perspective on the Pseudomonas aeruginosa orphan quorum sensing regulator QscR 10.3389/fcimb.2014.00152
Quorum sensing in Vibrio fischeri: Analysis of the LuxR DNA binding region by alanine-scanning mutagenesis 10.1128/JB.183.1.382-386.2001
Sodium-coupled motility in a swimming cyanobacterium 10.1128/jb.169.8.3429-3434.1987
Influence of quorum sensing and iron on twitching motility and biofilm formation in Pseudomonas aeruginosa 10.1128/JB.01473-07
Hfq-dependent alterations of the transcriptome profile and effects on quorum sensing in Pseudomonas aeruginosa 10.1111/j.1365-2958.2006.05032.x
Microbial sciences: The superficial life of microbes 10.1038/441300a
Acyl homoserine-lactone quorum-sensing signal generation 10.1073/pnas.96.8.4360
Quorum sensing influences Burkholderia thailandensis biofilm development and matrix production 10.1128/JB.00047-16
Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum 10.1073/pnas.1114125108
LuxR- and luxI-type quorum-sensing circuits are prevalent in members of the populus deltoides microbiome 10.1128/AEM.01417-13
The Single-Nucleotide Resolution Transcriptome of Pseudomonas aeruginosa Grown in Body Temperature 10.1371/journal.ppat.1002945
N-terminal amino acid sequences and amino acid compositions of the Spirochaeta aurantia flagellar filament polypeptides 10.1128/jb.173.3.1357-1359.1991
Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa 10.1016/j.bmcl.2007.11.095
Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor 10.1111/j.1365-2958.2005.04960.x
Complete genome sequence of Vibrio fischeri: A symbiotic bacterium with pathogenic congeners 10.1073/pnas.0409900102
Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing 10.1016/j.femsle.2005.09.023
Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264 10.1021/ol902751x
A LuxR homolog in a cottonwood tree endophyte that activates gene expression in response to a plant signal or specific peptides 10.1128/mBio.01101-16.
LasR variant cystic fibrosis isolates reveal an adaptable quorum-sensing hierarchy in Pseudomonas aeruginosa 10.1128/mBio.01513-16
A Burkholderia thailandensis acyl-homoserine lactone-independent orphan LuxR homolog that activates production of the cytotoxin malleilactone 10.1128/JB.00425-15
Microbiology: Plan B for quorum sensing 10.1038/nchembio.1233
Negative chemotaxis in Spirochaeta aurantia 10.1007/BF02092120
The basis of silver staining of bacterial lipopolysaccharides in polyacrylamide gels 10.1007/BF01568155
Rapid evolution of culture-impaired bacteria during adaptation to biofilm growth 10.1016/j.celrep.2013.12.019
Sociomicrobiology: The connections between quorum sensing and biofilms 10.1016/j.tim.2004.11.007
Sociality in Escherichia coli: Enterochelin is a private good at low cell density and can be shared at high cell density 10.1128/JB.02596-14
A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal 10.1073/pnas.0608348103
Virulence of Burkholderia mallei quorum-sensing mutants 10.1128/IAI.00048-13
Acylated homoserine lactone detection in Pseudomonas aeruginosa biofilms by radiolabel assay 10.1016/S0076-6879(01)36576-X
Glucose repression of luminescence and luciferase in vibrio fischeri 10.1007/BF00407937
Motility and chemotaxis of Spirochaeta aurantia: computer-assisted motion analysis. 10.1128/jb.170.4.1768-1774.1988
BadR and BadM proteins transcriptionally regulate two operons needed for anaerobic benzoate degradation by Rhodopseudomonas palustris 10.1128/AEM.00377-15
QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa 10.1073/pnas.051624298
The influence of iron on Pseudomonas aeruginosa physiology: A regulatory link between iron and quorum sensing 10.1074/jbc.M707840200
Long-chain acyl-homoserine lactone quorum-sensing regulation of Rhodobacter capsulatus gene transfer agent production 10.1128/JB.184.23.6515-6521.2002
Enhancement of antimicrobial activity against Pseudomonas aeruginosa by coadministration of G10KHc and tobramycin 10.1128/AAC.00509-06
Cloning and sequence analysis of flaA, a gene encoding a Spirochaeta aurantia flagellar filament surface antigen 10.1128/jb.171.3.1692-1697.1989
Role of flagella in virulence of the coral pathogen Vibrio coralliilyticus 10.1128/AEM.00198-09
Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia 10.1073/pnas.0308750101
The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent 10.1073/pnas.0808608105
Mutational analysis of Burkholderia thailandensis quorum sensing and self-aggregation 10.1128/JB.00591-09
Critical regions of the Vibrio fischeri LuxR protein defined by mutational analysis 10.1128/jb.172.7.3974-3979.1990
Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa 10.1073/pnas.96.24.13904
Transcriptome analysis of the Vibrio fischeri LuxR-LuxI regulon 10.1128/JB.00736-07
Quorum sensing in Vibrio fischeri: Elements of the luxl promoter 10.1046/j.1365-2958.1999.01261.x
Progress in and promise of bacterial quorum sensing research 10.1038/nature24624
Control of Vibrio fischeri lux gene transcription by a cyclic AMP receptor protein-luxR protein regulatory circuit. 10.1128/jb.170.9.4040-4046.1988
Nucleotide sequence and analysis of a gene encoding anthranilate synthase component I in Spirochaeta aurantia 10.1128/jb.173.2.541-548.1991
Bactericidal activity of mammalian cathelicidin-derived peptides 10.1128/IAI.68.5.2748-2755.2000
The Vibrio fischeri quorum-sensing systems ain and lux sequentially induce luminescence gene expression and are important for persistence in the squid host 10.1046/j.1365-2958.2003.t01-1-03585.x
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms 10.1038/35037627
Acyl-homoserine lactone-dependent eavesdropping promotes competition in a laboratory co-culture model 10.1038/ismej.2012.69
Promoter specificity in Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR 10.1073/pnas.0407229101
Iron and Pseudomonas aeruginosa biofilm formation 10.1073/pnas.0504266102
Quorum-sensing signals and quorum-sensing genes in Burkholderia vietnamiensis 10.1128/jb.184.4.1187-1191.2002
Delays in Pseudomonas aeruginosa quorum-controlled gene expression are conditional 10.1073/pnas.0503728102
Aryl-homoserine lactone quorum sensing in stem-nodulating photosynthetic bradyrhizobia 10.1073/pnas.1103821108
Complementation of a trpE deletion in Escherichia coli by Spirochaeta aurantia DNA encoding anthranilate synthetase component I activity. 10.1128/jb.169.8.3764-3769.1987
The intracellular polyglucose storage granules of Spirochaeta aurantia 10.1007/BF00407794
A component of innate immunity prevents bacterial biofilm development 10.1038/417552a
Octanoyl-homoserine lactone is the cognate signal for Burkholderia mallei BmaR1-BmaI1 quorum sensing 10.1128/JB.00317-07
Generation of virulence factor variants in Staphylococcus aureus biofilms 10.1128/JB.00789-07
Chemotaxis mutants of Spirochaeta aurantia. 10.1128/jb.171.1.606-611.1989
The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone 10.1128/JB.00246-08
Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism 10.1021/jacs.7b12240
luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria 10.1128/mSystems.00208-17
Hydrogel Effects Rapid Biofilm Debridement with ex situ Contact-Kill to Eliminate Multidrug Resistant Bacteria in vivo 10.1021/acsami.8b06262
An aryl-homoserine lactone quorum-sensing signal produced by a dimorphic prosthecate bacterium 10.1073/pnas.1808351115
The Pseudomonas aeruginosa Orphan Quorum Sensing Signal Receptor QscR Regulates Global Quorum Sensing Gene Expression by Activating a Single Linked Operon 10.1128/mBio.01274-18
A plant-responsive bacterial-signaling system senses an ethanolamine derivative 10.1073/pnas.1809611115
Modulation of Pseudomonas aeruginosa Quorum Sensing by Glutathione 10.1128/JB.00685-18
Quorum Sensing Signal Selectivity and the Potential for Interspecies Cross Talk 10.1128/mBio.00146-19
Social cheating in aPseudomonas aeruginosaquorum-sensing variant 10.1073/pnas.1819801116
Evolution of thePseudomonas aeruginosaquorum-sensing hierarchy 10.1073/pnas.1819796116
Virulence Factor Identification in the Banana Pathogen Dickeya zeae MS2 10.1128/AEM.01611-19
A rhlI 5′ UTR-Derived sRNA Regulates RhlR-Dependent Quorum Sensing in Pseudomonas aeruginosa 10.1128/mBio.02253-19
The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy 10.1021/acs.jnatprod.9b01237
Structural basis for a bacterial Pip system plant effector recognition protein 10.1073/pnas.2019462118
A covariation analysis reveals elements of selectivity in quorum sensing systems 10.1101/2021.03.25.437039
A covariation analysis reveals elements of selectivity in quorum sensing systems 10.7554/eLife.69169
Evolution of the quorum sensing regulon in cooperating populations of Pseudomonas aeruginosa 10.1101/2021.07.01.450773
Marnix H. Medema
Medema Marnix H.
ORCID: 0000-0002-2191-2821
Bioinformatics Approaches and Software for Detection of Secondary Metabolic Gene Clusters 10.1007/978-1-62703-122-6_2
Synthetic Biology in Streptomyces Bacteria 10.1016/b978-0-12-385075-1.00021-4
Computational approaches to natural product discovery 10.1038/nchembio.1884
Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms 10.1038/nrmicro2478
A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis 10.1371/journal.pcbi.1004016
Comparative genome-scale metabolic modeling of actinomycetes: The topology of essential core metabolism 10.1016/j.febslet.2011.06.014
MultiMetEval: Comparative and Multi-Objective Analysis of Genome-Scale Metabolic Models 10.1371/journal.pone.0051511
The future of industrial antibiotic production: From random mutagenesis to synthetic biology 10.4161/bbug.2.4.16114
Metabolomics methods for the synthetic biology of secondary metabolism 10.1016/j.febslet.2012.02.008
Computational tools for the synthetic design of biochemical pathways 10.1038/nrmicro2717
A predicted physicochemically distinct sub-proteome associated with the intracellular organelle of the anammox bacterium Kuenenia stuttgartiensis 10.1186/1471-2164-11-299
Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus 10.1111/j.1751-7915.2010.00226.x
Denitrifying bacteria anaerobically oxidize methane in the absence of Archaea 10.1111/j.1462-2920.2008.01724.x
Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters 10.1016/j.cell.2014.06.034
Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products 10.1371/journal.pcbi.1003822
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters 10.1093/nar/gkv437
Design-based re-engineering of biosynthetic gene clusters: plug-and-play in practice 10.1016/j.copbio.2013.03.006
Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block 10.1021/sb500368w
antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers 10.1093/nar/gkt449
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences 10.1093/nar/gkr466
The Sequence of a 1.8-Mb Bacterial Linear Plasmid Reveals a Rich Evolutionary Reservoir of Secondary Metabolic Pathways 10.1093/gbe/evq013
MS/MS networking guided analysis of molecule and gene cluster families 10.1073/pnas.1303471110
Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast 10.1093/molbev/mst025
Complete Genome Sequence of the Frog Pathogen Mycobacterium ulcerans Ecovar Liflandii 10.1128/jb.02132-12
NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity 10.1093/nar/gkr323
Mechanisms and Evolution of Control Logic in Prokaryotic Transcriptional Regulation 10.1128/mmbr.00037-08
Genomic mutational analysis of the impact of the classical strain improvement program on β-lactam producing Penicillium chrysogenum. 10.1186/s12864-015-2154-4
Leucanicidin and endophenasides result from methyl-rhamnosylation by the same tailoring enzymes in Kitasatospora sp. MBT66 10.1021/acschembio.5b00801
Computational strategies for genome-based natural product discovery and engineering in fungi 10.1016/j.fgb.2016.01.006
The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters 10.1093/nar/gkw960
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides 10.1038/nmicrobiol.2016.197
Editorial: Synthetic biology and bioinformatics 10.1039/c6np90031c
plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters 10.1093/nar/gkx305
Genome-based exploration of the specialized metabolic capacities of the genus Rhodococcus 10.1186/s12864-017-3966-1
Mining prokaryotes for antimicrobial compounds: from diversity to function 10.1093/femsre/fux014
Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters 10.1093/bib/bbx146
Standardization for natural product synthetic biology 10.1039/c6np00030d
Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways 10.1039/c6np00035e
Draft Genome Sequence of a Porcine Commensal, Rothia nasimurium , Encoding a Nonribosomal Peptide Synthetase Predicted To Produce the Ionophore Antibiotic Valinomycin 10.1128/genomea.00453-17
SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria 10.1093/bioinformatics/btx400
Collaborating with Undergraduates To Contribute to Biochemistry Community Resources 10.1021/acs.biochem.7b00872
Road MAPs to engineer host microbiomes. 10.1016/j.mib.2017.11.023
Genome-wide analysis of bacterial determinants of plant growth promotion and induced systemic resistance by Pseudomonas fluorescens. 10.1111/1462-2920.13927
Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveals convergent evolution. 10.1073/pnas.1705567114
antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification. 10.1093/nar/gkx319
Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products. 10.1016/j.fgb.2016.01.012
Exploration and exploitation of the environment for novel specialized metabolites. 10.1016/j.copbio.2018.01.017
Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology 10.1128/mSystems.00182-17
Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics. 10.1016/j.chembiol.2018.02.008
HEx: A heterologous expression platform for the discovery of fungal natural products. 10.1126/sciadv.aar5459
luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria. 10.1128/msystems.00208-17
A Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology. 10.1021/jacs.7b13292
Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium. 10.3389/fmicb.2018.01158
Involvement of Burkholderiaceae and sulfurous volatiles in disease-suppressive soils. 10.1038/s41396-018-0186-x
Genomic Identification and Analysis of Specialized Metabolite Biosynthetic Gene Clusters in Plants Using PlantiSMASH. 10.1007/978-1-4939-7874-8_15
A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene cluster (MIBiG) repository: prospects for research-based educational experiences 10.1186/s40793-018-0318-y
The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters 10.1093/nar/gky1060
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1101/463620
Mining bacterial genomes to reveal secret synergy 10.1074/jbc.H118.006669
Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters 10.1038/s42003-019-0333-6
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1111/tpj.14292
A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters 10.1186/s13104-019-4222-3
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline 10.1093/nar/gkz310
MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools 10.1101/654459
BiosyntheticSPAdes: Reconstructing Biosynthetic Gene Clusters From Assembly Graphs 10.1101/gr.243477.118
Genome Mining Approaches to Bacterial Natural Product Discovery 10.1016/b978-0-12-409547-2.14627-x
Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines 10.1039/C9NP00021F
PlantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters 10.1101/083535
MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools 10.3390/metabo9070144
Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L. 10.3389/fpls.2019.00846
Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome 10.1126/science.aaw9285
MIBiG 2.0: a repository for biosynthetic gene clusters of known function 10.1093/nar/gkz882
A metabolic pathway for bile acid dehydroxylation by the gut microbiome 10.1101/758557
Coevolution-based prediction of protein-protein interactions in polyketide biosynthetic assembly lines 10.1101/669291
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery 10.1021/acscentsci.9b00806
Cultivation and functional characterization of 79 planctomycetes uncovers their unique biology 10.1038/s41564-019-0588-1
Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia 10.1101/856955
Drivers of metabolic diversification: how dynamic genomic neighbourhoods generate new biosynthetic pathways in the Brassicaceae 10.1111/nph.16338
Microbial and volatile profiling of soils suppressive to Fusarium culmorum of wheat 10.1098/rspb.2019.2527
Computational genomic discovery of diverse gene clusters harboring Fe-S flavoenzymes in anaerobic gut microbiota 10.1101/2020.03.06.976126
RRE-Finder: A Genome-Mining Tool for Class-Independent RiPP Discovery 10.1101/2020.03.14.992123
Linking genomics and metabolomics to chart specialized metabolic diversity 10.1039/D0CS00162G
Computational genomic discovery of diverse gene clusters harbouring Fe-S flavoenzymes in anaerobic gut microbiota 10.1099/mgen.0.000373
ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining 10.1093/nar/gkaa374
Integration of machine learning and pan-genomics expands the biosynthetic landscape of RiPP natural products 10.1101/2020.05.19.104752
Ecology and genomics of Actinobacteria: new concepts for natural product discovery 10.1038/s41579-020-0379-y
The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms 10.1038/s42003-020-0993-2
BiG-SLiCE: A Highly Scalable Tool Maps the Diversity of 1.2 Million Biosynthetic Gene Clusters 10.1101/2020.08.17.240838
Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia 10.1074/jbc.RA120.013528
Microbial natural product databases: moving forward in the multi-omics era 10.1039/D0NP00053A
Author Correction: The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms 10.1038/s42003-020-01228-1
RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery 10.1128/mSystems.00267-20
Author Correction: The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms 10.1038/s42003-020-01271-y
BiG-FAM: the biosynthetic gene cluster families database 10.1093/nar/gkaa812
Coevolution-based prediction of protein–protein interactions in polyketide biosynthetic assembly lines 10.1093/bioinformatics/btaa595
The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes 10.1093/nar/gkaa978
Pan-genome analysis and ancestral state reconstruction of class halobacteria: probability of a new super-order 10.1038/s41598-020-77723-6
BiG-MAP: an automated pipeline to profile metabolic gene cluster abundance and expression in microbiomes 10.1101/2020.12.14.422671
Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides 10.1371/journal.pbio.3001026
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters 10.1093/gigascience/giaa154
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases 10.1039/D0NP00090F
Do size and shape matter? Exploring the interactions and the metabolome of the soil isolate Hylemonella gracilis 10.1101/2021.02.11.430889
A systematic analysis of metabolic pathways in the human gut microbiota 10.1101/2021.02.25.432841
Omics-based strategies to discover novel classes of RiPP natural products 10.1016/j.copbio.2020.12.008
Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria 10.1038/s41467-021-21163-x
The Surfactin-Like Lipopeptides From Bacillus spp.: Natural Biodiversity and Synthetic Biology for a Broader Application Range 10.3389/fbioe.2021.623701
Mining metagenomes for natural product biosynthetic gene clusters: unlocking new potential with ultrafast techniques 10.1101/2021.01.20.427441
Extracting the GEMs: Genotype, Environment, and Microbiome Interactions Shaping Host Phenotypes 10.3389/fmicb.2020.574053
A mammalian commensal of the oropharyngeal cavity produces antibiotic and antiviral valinomycin in vivo 10.21203/rs.3.rs-126949/v1
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters 10.1016/j.chembiol.2020.11.009
cblaster: a remote search tool for rapid identification and visualisation of homologous gene clusters 10.1101/2020.11.08.370601
antiSMASH 6.0: improving cluster detection and comparison capabilities 10.1093/nar/gkab335
The gutSMASH web server: automated identification of primary metabolic gene clusters from the gut microbiota 10.1093/nar/gkab353
Mining genomes to illuminate the specialized chemistry of life 10.1038/s41576-021-00363-7
Dominant drivers of the human plasma metabolome 10.21203/rs.3.rs-688716/v1
A global survey of specialized metabolic diversity encoded in bacterial genomes 10.1101/2021.08.11.455920
cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters 10.1093/bioadv/vbab016