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Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence

Brodin, P. Majlessi, L. Marsollier, L. de Jonge, M. I. Bottai, D. Demangel, C. Hinds, J. Neyrolles, O. Butcher, P. D. Leclerc, C. Cole, S. T. Brosch, R.

Infection and Immunity, 2006

https://doi.org/10.1128/iai.74.1.88-98.2006

Philip Butcher

Butcher Philip

ORCID: 0000-0003-1223-9097

Intracellular Microbe Whole-Genome Expression Profiling: Methodological Considerations and Biological Inferences 10.1002/9783527629176.ch9

Investigation of mycobacteria in Crohn's disease tissue by Southern blotting and DNA hybridisation with cloned mycobacterial genomic DNA probes from a Crohn's disease isolated mycobacteria 10.1136/gut.29.9.1222

Fidelity and reproducibility of antisense RNA amplification for the study of gene expression in human CD34 ⁺ haemopoietic stem and progenitor cells 10.1046/j.1365-2141.2003.04440.x

Analysis of whole-genome microarray replicates using mixed models 10.1093/bioinformatics/19.1.53

Evidence for a role for interleukin-17, Th17 cells and iron homeostasis in protective immunity against tuberculosis in cynomolgus macaques 10.1371/journal.pone.0088149

Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv 10.1111/j.1472-765X.2005.01659.x

Use of Genome Level-Informed PCR as a New Investigational Approach for Analysis of Outbreak-Associated Mycobacterium tuberculosis Isolates 10.1128/JCM.42.5.1890-1896.2004

Characterization of a haemolysin from Mycobacterium tuberculosis with homology to a virulence factor of Serpulina hyodysenteriae 10.1099/00221287-144-5-1205

Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family 10.1084/jem.190.5.717

Molecular epidemiology of tuberculosis in London 1995-7 showing low rate of active transmission 10.1136/mp.56.2.121

Application of the polymerase chain reaction to the diagnosis of human toxoplasmosis 10.1016/0163-4453(93)92788-X

Whole-genome sequencing illuminates the evolution and spread of multidrug-resistant tuberculosis in Southwest Nigeria 10.1371/journal.pone.0184510

DNA microarrays for virus detection in cases of central nervous system infection 10.1128/JCM.42.12.5811-5818.2004

Antibodies to gut protozoa in commercial immunoglobulin preparations 10.1016/0035-9203(91)90163-S

cDNA-RNA subtractive hybridization reveals increased expression of mycocerosic acid synthase in intracellular Mycobacterium bovis BCG 10.1099/00221287-147-8-2293

Benzothiazinones Kill Mycobacterium tuberculosis by blocking Arabinan synthesis 10.1126/science.1171583

Methionine sulfoximine resistance in mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1 10.1089/mdr.2010.0125

Whole genome analysis using microarrays 10.1007/978-1-59745-207-6_6

Genome sequencing and characterization of an extensively drug-resistant sequence type 111 serotype O12 hospital outbreak strain of Pseudomonas aeruginosa 10.1111/1469-0691.12528

Detection of mRNA transcripts and active transcription in persistent Mycobacterium tuberculosis induced by exposure to rifampin or pyrazinamide 10.1128/JB.182.22.6358-6365.2000

A polymerase chain reaction to detect a spliced late transcript of human cytomegalovirus in the blood of bone marrow transplant recipients 10.1016/0166-0934(95)01900-6

Differential expression of mycobacterial proteins following phagocytosis by macrophages 10.1099/00221287-147-2-459

Mycobacterial P 1-Type ATPases mediate resistance to Zinc poisoning in human macrophages 10.1016/j.chom.2011.08.006

Advanced significance analysis of microarray data based on weighted resampling: A comparative study and application to gene deletions in Mycobacterium bovis 10.1093/bioinformatics/btg417

BμG@Sbase - A microbial gene expression and comparative genomic database 10.1093/nar/gkr796

Genetic Composition of Mycobacterium bovis BCG Substrain Sofia [2] 10.1128/JCM.41.11.5349.2003

A comparative study of haemoglobins from the artiodactyla by isoelectric focusing 10.1016/0305-0491(77)90025-6

XDR-TB transmission in London: Case management and contact tracing investigation assisted by early whole genome sequencing 10.1016/j.jinf.2016.04.037

Haemoglobins and erythrocyte sickling in the artiodactyla: A survey 10.1016/0300-9629(77)90134-7

Cytokine mRNA expression in Mycobacteriam ulcerans-infected human skin and correlation with local inflammatory response 10.1128/IAI.74.5.2917-2924.2006

Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases 10.1128/JCM.02993-14

High-dose rifapentine with moxifloxacin for pulmonary tuberculosis 10.1056/NEJMoa1314210

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum 10.1371/journal.pmed.0050075

Performance evaluation of automated urine microscopy as a rapid, non-invasive approach for the diagnosis of non-gonococcal urethritis 10.1136/sextrans-2014-051761

The nature of erythrocyte sickling in sheep 10.1016/0300-9629(79)90462-6

Serodiagnosis of giardiasis 10.1016/0888-0786(87)90001-1

Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages 10.1371/journal.pone.0001403

Comparative studies on the glycoprotein composition of mammalian platelets 10.1016/0305-0491(77)90240-1

Design, validation, and application of a seven-strain Staphylococcus aureus PCR product microarray for comparative genomics 10.1128/AEM.71.11.7504-7514.2005

Drug resistant TB: UK multicentre study (DRUMS): Treatment, management and outcomes in London and West Midlands 2008–2014 10.1016/j.jinf.2016.12.005

Comparison of human low-molecular-weight RNA from normal and Crohn's disease derived blood and mesenteric, lymph node leucocytes 10.1042/bst0121112

Microarrays for microbes: The BμGΣ approach 10.1002/cfg.187

Gene expression during host—pathogen interactions: Approaches to bacterial mRNA extraction and labelling for microarray analysis 10.1016/S0580-9517(02)33009-5

Whole genome comparison of Campylobacter jejuni human isolates using a low-cost microarray reveals extensive genetic diversity 10.1101/gr.185801

Microarray-based comparative genomics: Genome plasticity in Mycobacterium bovis 10.1002/cfg.182

The heat shock response of Mycobacterium tuberculosis: Linking gene expression, immunology and pathogenesis 10.1002/cfg.183

Prevalence of giardia in dogs and cats in the United Kingdom: Survey of an essex veterinary clinic 10.1016/0035-9203(89)90330-1

Potassium availability triggers Mycobacterium tuberculosis transition to, and resuscitation from, non-culturable (dormant) states 10.1098/rsob.140106

The 1st Symposium of the Wellcome Trust-funded Multi-collaborative Microbial Pathogen Microarray Facility - BμGΣ 2002: 'Bacterial pathogens, microarrays and functional genomics' 10.1002/cfg.189

Human cytomegalovirus genome sequences in lymph nodes 10.1016/S1286-4579(99)80023-9

Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial 10.1186/s12916-017-0834-4

The electrophoretic analysis of low molecular weight nucleic acids from Crohn's disease tissues in the search for an unconventional small infections agent 10.1007/BF01310895

Modulation of pristane-induced arthritis by mycobacterial antigens 10.3109/08916939108994706

Association of cytomegalovirus infection with post‐transplantation cardiac rejection as studied using the polymerase chain reaction 10.1002/jmv.1890420412

Gene markers in 40 Przewalski horses: Equus przewahkii 10.1111/j.1748-1090.1979.tb00570.x

Clinical use of whole genome sequencing for Mycobacterium tuberculosis 10.1186/s12916-016-0598-2

Early detection of cytomegalovirus (CMV) infection in bone marrow transplant patients by reverse transcription-PCR for CMV spliced late gene UL21.5: A two site evaluation 10.1016/S1386-6532(01)00209-8

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/IAI.74.1.88-98.2006

Molecular epidemiology of tuberculosis in London 1995-7 showing low rate of active transmission 10.1136/thorax.57.7.617

Development of an in vitro model of Toxoplasma gondii cyst formation 10.1111/j.1574-6968.1993.tb06593.x

Quantification of cytomegalovirus DNA in blood specimens from bone marrow transplant recipients by the polymerase chain reaction 10.1016/0166-0934(94)90077-9

Microarray analysis of whole genome expression of intracellular Mycobacterium tuberculosis 10.2174/156652407780598548

Increased transcription of a potential sigma factor regulatory gene Rv1364c in Mycobacterium bovis BCG while residing in macrophages indicates use of alternative promoters 10.1016/j.femsle.2004.02.028

Genomic analysis of Mycobacterium tuberculosis complex strains used for production of purified protein derivative 10.1128/JCM.41.8.3929-3932.2003

Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: Identification of a novel wax ester 10.1099/mic.0.2006/004317-0

Minisatellites corresponding to the human polycore probes 33.6 and 33.15 in the genome of the most 'primitive' known eukaryote Giardia lamblia 10.1016/0378-1119(95)00572-5

Determination of Mycobacterium leprae Viability by Polymerase Chain Reaction Amplification of 71-kDa Heat-Shock Protein mRNA 10.1093/infdis/168.3.799

Microarrays reveal that each of the ten dominant lineages of Staphylococcus aureus has a unique combination of surface-associated and regulatory genes 10.1128/JB.188.2.669-676.2006

Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment 10.1084/jem.20030846

Point-of-care antibiotic susceptibility testing for gonorrhoea: Improving therapeutic options and sparing the use of cephalosporins 10.1136/sti.2010.044230

Kinetics of the in vitro gelation of a sickling haemoglobin from hog deer (Axis porcinus) 10.1016/0005-2795(79)90070-9

Evolutionary relationships among strains of Mycobacterium tuberculosis with few copies of IS6110 10.1128/JB.185.8.2555-2562.2003

Mycobacterium tuberculosis expresses two chaperonin-60 homologs 10.1073/pnas.90.7.2608

Microarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies 10.1186/1471-2164-9-94

Efficient translation and polyribosome binding of ¹²⁵I-labelled rabbit globin messenger ribonucleoprotein 10.1016/0014-5793(83)80130-6

Microarrays for Mycobacterium tuberculosis 10.1016/j.tube.2004.01.002

Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting 10.1017/S0950268810000208

RNA profiling in host-pathogen interactions 10.1016/j.mib.2007.05.013

The in vitro model of tissue cyst formation in Toxoplasma gondii 10.1016/0169-4758(94)90148-1

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy 10.1186/s12916-016-0609-3

Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin 10.1093/jac/dkn387

Professor D A Mitchison: 60 years of contributions to the chemotherapy of tuberculosis 10.1016/j.tube.2010.03.004

Accurate detection of Neisseria gonorrhoeae ciprofloxacin susceptibility directly from genital and extragenital clinical samples: Towards genotype-guided antimicrobial therapy 10.1093/jac/dkv432

High prevalence of antibiotic-resistant mycoplasma genitalium in nongonococcal urethritis: The need for routine testing and the inadequacy of current treatment options 10.1093/cid/cit752

An effective method of RNA extraction from bacteria refractory to disruption, including mycobacteria 10.1093/nar/25.3.675

Protein synthesis is shutdown in dormant Mycobacterium tuberculosis and is reversed by oxygen or heat shock 10.1016/S0378-1097(97)00514-4

Genomic diversity among Beijing and non-Beijing Mycobacterium tuberculosis isolates from Myanmar 10.1371/journal.pone.0001973

Polyribosome binding of rabbit globin messenger RNA and messenger ribonucleoprotein labelled with bacteriophage-T4 RNA ligase and 5′-[³²P] phosphocytidine 3′-phosphate 10.1093/nar/11.1.1

Recognition of tissue cyst-specific antigens in reactivating toxoplasmosis 10.1099/00222615-46-7-587

Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages 10.1371/journal.pone.0011066

New strategies in microbiological diagnosis 10.1016/0195-6701(91)90017-3

Characterisation of bovine leukocyte ig-like receptors 10.1371/journal.pone.0034291

Quantitation of Toxoplasma gondii DNA in a competitive nested polymerase chain reaction 10.1136/jcp.52.1.61

Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever 10.1128/AAC.00645-08

Estimation of the rate of unrecognized cross-contamination with Mycobacterium tuberculosis in London Microbiology Laboratories 10.1128/JCM.40.11.4100-4104.2002

Use of DNA arrays to study transcriptional responses to antimycobacterial compounds. 10.1007/978-1-60327-279-7_6

DNA probes for the faecal diagnosis of Giardia lamblia infections in man 10.1042/bst0170363

The influence of reduced oxygen availability on pathogenicity and gene expression in Mycobacterium tuberculosis 10.1016/j.tube.2003.12.011

Oleoyl coenzyme a regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria 10.1074/jbc.M114.577338

Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: A model for persistent organisms? 10.1016/j.tube.2003.12.010

Examining the basis of isoniazid tolerance in nonreplicating Mycobacterium tuberculosis using transcriptional profiling 10.4155/fmc.10.219

Characterization of the heat shock response in Mycobacterium bovis BCG 10.1128/jb.173.24.7982-7987.1991

Diagnosis of Pneumocystis carinii pneumonia: Immunofluorescence staining, simple PCR or nPCR 10.1016/S0163-4453(99)90106-8

Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions 10.1128/AAC.02774-13

Extraction and characterization of mRNA from mycobacteria: implication for virulence gene identification 10.1016/0167-7012(91)90010-N

The use of DNA probes identifying restriction‐fragment‐length polymorphisms to examine the Mycobacterium avium complex 10.1111/j.1365-2958.1987.tb01934.x

An integrated whole genome analysis of Mycobacterium tuberculosis reveals insights into relationship between its genome, transcriptome and methylome 10.1038/s41598-019-41692-2

Platelet shape change: Induction by trypsin and release of an acidic macroglycopeptide from washed human platelets and from those of three cases of glanzmann’s thrombasthenia 10.1159/000214057

Diagnostic accuracy of a prototype rapid chlamydia and gonorrhoea recombinase polymerase amplification assay: a multicentre cross-sectional preclinical evaluation 10.1016/j.cmi.2018.06.003

Priscille Brodin

Brodin Priscille

ORCID: 0000-0003-0991-7344

Email: priscille.brodin@inserm.fr

How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011

Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227 10.3390/toxins9070227.

Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections 10.2217/nnm-2016-0364

Cyclodextrin-based nanocarriers containing a synergic drug combination: a potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030 10.1016/j.ijpharm.2017.05.030.

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z

Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005 10.1016/j.drudis.2017.05.005.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535

Impact of pe_ pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis 10.3389/fcimb.2017.00137

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619

Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129 10.1002/cyto.a.23129.

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j

Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5

Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization 10.1016/j.str.2016.07.009

Mycolactone The amazing analgesic mycobacterial toxin 10.1051/medsci/20163202007

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297

2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650

High content screening in chemical biology: overview and main challenges 10.1051/medsci/20153102016

High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis 10.1128/aac.03705-14

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15

Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays 10.1007/978-1-4939-2450-9_24

A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening 10.3791/51114

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/jm500422b

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040

Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022

A novel specific edge effect correction method for RNA interference screenings 10.1093/bioinformatics/btr648

Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779

Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u

The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence 10.1371/journal.pone.0047573

Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis 10.1371/journal.pone.0026675

Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200076a

High-content screening in infectious diseases 10.1016/j.cbpa.2011.05.023

Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ 10.1099/mic.0.038133-0

High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100

High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery 10.4155/fmc.10.223

Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting 10.1016/j.biomaterials.2009.09.044

Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure 10.1177/1087057108328762

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis 10.1126/science.1171583

High Content Screening Identifies Decaprenyl-Phosphoribose 2 ' Epimerase as a Target for Intracellular Antimycobacterial Inhibitors 10.1371/journal.ppat.1000645

Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507

Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033

Aquatic insects and transmission of Mycobacterium ulcerans 10.1051/medsci/20072367572

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 10.1128/jb.00469-07

Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis 10.1371/journal.ppat.0030062

Protection against mycobacterium ulcerans lesion development by exposure to aquatic insect saliva 10.1371/journal.pmed.0040064

Support vector machines for automatic detection of tuberculosis bacteria in confocal microscopy images 10.1109/isbi.2007.356794

Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues 10.1016/j.bmc.2006.12.009

An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis 10.1128/iai.74.4.2128-2137.2006

Benzofuro 3,2-f 1 benzopyrans: A new class of antitubercular agents 10.1016/j.bmc.2006.03.033

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/iai.74.1.88-98.2006

High frequency of CD4(+) T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection 10.1128/iai.02086-05

Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence 10.1128/jb.00631-06

Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis 10.1016/j.tube.2004.09.009

Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200

Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics 10.1099/mic.0.27799-0

Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions 10.1016/j.jmb.2005.05.049

Tuberculosis: from genome to vaccine 10.1586/14760584.4.4.541

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6 10.1128/iai.72.4.2170-2176.2004

Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468

ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007

Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex 10.1099/mic.0.26662-0

CD8(+)-T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family 10.1128/iai.71.12.7173-7177.2003

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/nm859

A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299

Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant 10.1128/iai.70.10.5568-5578.2002

Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides 10.1021/bi015732y

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x

6-Oxocytidine containing oligonucleotides inhibit the HIV-1 integrase in vitro 10.1081/ncn-100002322

Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase 10.1021/bi000398b

Inhibition of the human immunodeficiency virus type 1 DNA integration by modified oligonucleotides 10.1023/a:1026631910681

Branched oligonucleotide-intercalator conjugate forming a parallel stranded structure inhibits HIV-1 integrase 10.1016/s0014-5793(99)01350-2

Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides 10.1080/07328319908044831

Optimization of alternate-strand triple helix formation at the 5 '-TpA-3 ' and 5 '-ApT-3 ' junctions 10.1093/nar/27.15.3029

A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus 10.1074/jbc.272.25.16010

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371 10.15252/embr.201744371.

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091

Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017 10.1016/j.mib.2017.11.017.

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101 10.1016/j.celrep.2017.08.101.

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114 10.1073/pnas.1707840114.

Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry 10.1128/jvi.01982-17

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125

Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025

Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation 10.3389/fimmu.2018.00086

Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis 10.1128/aac.00359-18

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4

Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030

Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101

Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129

A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening 10.1002/cyto.a.20627

Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360

Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation 10.1074/mcp.RA119.001316

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902

Mitochondrial Dynamics and Activity in Legionella-Infected Cells 10.1007/978-1-4939-9048-1_13

Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258

Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication 10.1128/jvi.02009-18

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Type VII Secretion Systems in Gram-Positive Bacteria 10.1007/82_2015_5015

Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: ‘Aethiops vetus’ 10.1099/mgen.0.000063

Leprosy in red squirrels 10.1126/science.aal0145

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection 10.1371/journal.ppat.1005770

pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence 10.1038/nmicrobiol.2015.19

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence ofMycobacterium marinumin multiple hosts 10.1111/cmi.12606

The PE and PPE Protein Families of Mycobacterium tuberculosis 10.1002/9783527611614.ch7

Influence of ESAT-6 Secretion System 1 (RD1) of Mycobacterium tuberculosis on the Interaction between Mycobacteria and the Host Immune System 10.4049/jimmunol.174.6.3570

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125

ESAT-6–dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo 10.1172/jci84978

Cutting-edge science and the future of tuberculosis control 10.2471/blt.06.035386

ESAT-6 and the Mycobacterial ESX Secretion Systems 10.1128/9781555815783.ch13

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection 10.1371/journal.ppat.1007139

Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity 10.1093/gbe/evy145

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach 10.1016/j.jprot.2018.09.013

Update on the virulence factors of the obligate pathogen Mycobacterium tuberculosis and related tuberculosis-causing mycobacteria 10.1016/j.meegid.2018.12.013

Shared Pathogenomic Patterns Characterize a New Phylotype, Revealing Transition toward Host-Adaptation Long before Speciation of Mycobacterium tuberculosis 10.1093/gbe/evz162

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis. 10.1021/acsnano.8b07902

Mycobacterial virulence: impact on immunogenicity and vaccine research 10.12688/f1000research.20572.1

TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages 10.1038/s41467-020-14508-5

Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis 10.1038/s41598-020-58967-8

ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins 10.1128/microbiolspec.psib-0029-2019

ESX-4, un système de sécrétion mycobactérien ancestral, essentiel pour la croissance de Mycobacterium abscessus dans les phagocytes environnementaux et humains 10.1051/medsci/2018196

Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages 10.1371/journal.ppat.1008069

A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies 10.1126/sciadv.aaz1767

Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential 10.1016/j.ebiom.2020.102761

Mucosal delivery of ESX-1–expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes 10.1073/pnas.2003235117

Le BCG : histoire moléculaire et nouvelles perspectives 10.1016/s0761-8425(08)56032-3

Breaching the phagosome, the case of the tuberculosis agent 10.1111/cmi.13344

Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505

The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection 10.7554/elife.55692

IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo 10.1128/mSphere.00153-21

ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains 10.1128/mBio.00965-21

Evolution of Mycobacterium tuberculosis : New Insights into Pathogenicity and Drug Resistance 10.1128/microbiolspec.tbtb2-0020-2016

Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors 10.3389/fcimb.2020.00420

Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli 10.1038/s41564-021-00938-4

Caroline Demangel

Demangel Caroline

ORCID: 0000-0001-7848-586X

https://research.pasteur.fr/en/team/immunobiology-of-infection/

Recombinant Antibodies against Mycolactone 10.3390/toxins11060346

Shaping mycolactone for therapeutic use against inflammatory disorders 10.1126/SCITRANSLMED.AAB0458

Synthetic Variants of Mycolactone Bind and Activate Wiskott-Aldrich Syndrome Proteins 10.1021/JM5008819

Adhesion of the ulcerative pathogen Mycobacterium ulcerans to DACC-coated dressings 10.12968/JOWC.2014.23.8.417

Understanding Buruli Ulcer (Mycobacterium ulcerans Disease) 10.1128/9781555816803.CH12

Ipomoeassin F Binds Sec61 alpha to Inhibit Protein Translocation 10.1021/JACS.8B13506

Mycolactone subverts immunity by selectively blocking the Sec61 translocon 10.1084/JEM.20160662

Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli 10.1016/J.IMMUNI.2014.03.002

Proteomic Analysis of the SH2Domain-containing Leukocyte Protein of 76 kDa (SLP76) Interactome 10.1074/MCP.M112.025908

Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens 10.1007/S00018-014-1561-Z

Buruli ulcer disease: prospects for a vaccine 10.1007/S00430-009-0109-6

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease 10.1371/JOURNAL.PNTD.0002786

Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production 10.1002/1521-4141(200204)32:4<994::AID-IMMU994>3.3.CO;2-Y

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans 10.1038/NRMICRO2077

Mycolactone Diffuses into the Peripheral Blood of Buruli Ulcer Patients - Implications for Diagnosis and Disease Monitoring 10.1371/JOURNAL.PNTD.0001237

Molecular Mimicry between a Monoclonal Antibody and One Subunit of Crotoxin, a Heterodimeric Phospholipase A2 Neurotoxin 10.1515/BC.1999.071

Antigen Discovery: a Postgenomic Approach to Leprosy Diagnosis 10.1128/IAI.74.1.175-182.2006

Zika virus induces massive cytoplasmic vacuolization and paraptosis‐like death in infected cells 10.15252/EMBJ.201695597

Comparison of various methods for monitoring hybridoma cell proliferation 10.1016/0022-1759(90)90379-A

Immunosuppressive Signature of Cutaneous Mycobacterium ulcerans Infection in the Peripheral Blood of Patients with Buruli Ulcer Disease 10.1086/646615

Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer 10.1126/SCITRANSLMED.3003586

Mycobacterial Phenolic Gycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages 10.3389/FIMMU.2018.00002

A Diverted Total Synthesis of Mycolactone Analogues: An Insight into Buruli Ulcer Toxins 10.1002/CHEM.201102542

Mycobacterium leprae Phenolglycolipid-1 Expressed by Engineered M. bovis BCG Modulates Early Interaction with Human Phagocytes 10.1371/JOURNAL.PPAT.1001159

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone 10.1084/JEM.20070234

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export 10.1073/PNAS.1705242114

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin 10.1111/J.1462-5822.2005.00546.X

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6 10.1128/IAI.72.4.2170-2176.2004

Mycolactone displays anti-inflammatory effects on the nervous system 10.1371/JOURNAL.PNTD.0006058

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression 10.1073/PNAS.1016496108

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering 10.1002/CBIC.200700411

Targeting Dendritic Cells with Antigen-Containing Liposomes 10.1158/0008-5472.CAN-04-0138

Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature 10.1074/MCP.RA118.000824

Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8(+) T cells with specificity for a novel mycobacterial epitope 10.1093/INTIMM/13.4.451

Modular total syntheses of mycolactone A/B and its [ ² H]-isotopologue 10.1039/C7OB01943B

TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection 10.4049/JIMMUNOL.168.9.4620

Factors controlling cell proliferation and antibody production in mouse hybridoma cells: I. Influence of the amino acid supply 10.1002/BIT.260380602

Differential Effects of Prior Exposure to Environmental Mycobacteria on Vaccination with Mycobacterium bovis BCG or a Recombinant BCG Strain Expressing RD1 Antigens 10.1128/IAI.73.4.2190-2196.2005

Phage-displayed and soluble mouse scFv fragments neutralize rabies virus 10.1016/S0166-0934(97)00099-2

Towards an immunodiagnostic test for leprosy 10.1016/J.MICINF.2006.04.002

Interaction of dendritic cells with mycobacteria: Where the action starts 10.1046/J.1440-1711.2000.00935.X

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation 10.1172/JCI66576

Stimulation of Dendritic Cells via CD40 Enhances Immune Responses to Mycobacterium tuberculosis Infection 10.1128/IAI.69.4.2456-2461.2001

Role of Metabolic Waste Products in the Control of Cell Proliferation and Antibody Production by Mouse Hybridoma Cells 10.1089/HYB.1992.11.311

Inactivation of Rv2525c, a Substrate of the Twin Arginine Translocation (Tat) System of Mycobacterium tuberculosis, Increases -Lactam Susceptibility and Virulence 10.1128/JB.00631-06

Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guerin-infected dendritic cells 10.1002/(SICI)1521-4141(199906)29:06<1972::AID-IMMU1972>3.3.CO;2-T

Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism 10.1099/0022-1317-82-8-1885

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events 10.4049/JIMMUNOL.0902854

Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs 10.1371/JOURNAL.PNTD.0000325

Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence 10.1128/IAI.74.1.88-98.2006

Tuberculosis: from genome to vaccine 10.1586/14760584.4.4.541

Single chain antibody fragments for the selective targeting of antigens to dendritic cells 10.1016/J.MOLIMM.2004.09.034

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses 10.1016/J.CELREP.2016.08.011

Lipids of Pathogenic Mycobacteria: Contributions to Virulence and Host Immune Suppression 10.1111/J.1865-1682.2009.01072.X

Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library 10.1016/S1380-2933(97)00068-7

Combining phage display and molecular modeling to map the epitope of a neutralizing antitoxin antibody 10.1046/J.1432-1327.2000.01244.X

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/NM859

Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease 10.1038/SREP17693

Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library 10.1016/S0161-5890(96)00058-2

Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer 10.1016/J.MICINF.2006.03.009

Lactate dehydrogenase (LDH) activity of the number of dead cells in the medium of cultured eukaryotic cells as marker 10.1016/0168-1656(92)90158-6

Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures 10.1016/J.CHOM.2010.10.009

Priming by DNA Immunization Augments Protective Efficacy of Mycobacterium bovis Bacille Calmette-Guerin against Tuberculosis 10.1128/IAI.69.6.4174-4176.2001

Proteomic Analysis of the SH2 Domain-containing Leukocyte Protein of 76 kDa (SLP76) Interactome in Resting and Activated Primary Mast Cells 10.1074/MCP.A112.025908

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria 10.1039/B803101K

Pathogenic and immunosuppressive properties of mycobacterial phenolic glycolipids 10.1016/J.BIOCHI.2017.03.012

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria 10.1111/J.1462-5822.2012.01799.X

Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease 10.1111/BOC.201800030

HOST IMMUNOMODULATION BY MYCOLACTONE, THE MYCOBACTERIUM ULCERANS TOXIN 10.1016/J.TOXICON.2017.12.018

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges 10.1073/PNAS.1714765115

Parallel derivation of isogenic human primed and naive induced pluripotent stem cells 10.1038/S41467-017-02107-W

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors 10.1038/S41590-018-0049-7

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines 10.1186/S13073-018-0568-8

Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis 10.1093/EMBOJ/19.7.1525

Jason Hinds

Hinds Jason

ORCID: 0000-0002-2739-1908

Pneumococcal carriage in vaccine-eligible children and unvaccinated infants in Lao PDR two years following the introduction of the 13-valent pneumococcal conjugate vaccine. 10.1016/j.vaccine.2018.10.077

Effect of ten-valent pneumococcal conjugate vaccine introduction on pneumococcal carriage in Fiji: results from four annual cross-sectional carriage surveys. 10.1016/S2214-109X(18)30383-8

Carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in Indonesian children: A cross-sectional study. 10.1371/journal.pone.0195098

The PneuCarriage Project: A Multi-Centre Comparative Study to Identify the Best Serotyping Methods for Examining Pneumococcal Carriage in Vaccine Evaluation Studies 10.1371/journal.pmed.1001903

Comparison of two-dose priming plus 9-month booster with a standard three-dose priming schedule for a ten-valent pneumococcal conjugate vaccine in Nepalese infants: a randomised, controlled, open-label, non-inferiority trial. 10.1016/S1473-3099(15)70007-1

Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries: a protocol for a prospective observational study. 10.1136/bmjopen-2018-021512

A novel genetic variant of Streptococcus pneumoniae serotype 11A discovered in Fiji. 10.1016/j.cmi.2017.06.031

Discovery of a Streptococcus pneumoniae serotype 33F capsular polysaccharide locus that lacks wcjE and contains a wcyO pseudogene. 10.1371/journal.pone.0206622

Pneumococcal Serotypes Colonise the Nasopharynx in Children at Different Densities. 10.1371/journal.pone.0163435

Impact of the 13-valent pneumococcal conjugate vaccine on Streptococcus pneumoniae multiple serotype carriage. 10.1016/j.vaccine.2016.06.017

Serotype-Specific Correlates of Protection for Pneumococcal Carriage: An Analysis of Immunity in 19 Countries. 10.1093/cid/cix895

Identification of Streptococcus suis Meningitis through Population-Based Surveillance, Togo, 2010-2014. 10.3201/eid2207.151511

Accurate detection of Neisseria gonorrhoeae ciprofloxacin susceptibility directly from genital and extragenital clinical samples: towards genotype-guided antimicrobial therapy. 10.1093/jac/dkv432

XDR-TB transmission in London: Case management and contact tracing investigation assisted by early whole genome sequencing. 10.1016/j.jinf.2016.04.037

Clinical use of whole genome sequencing for Mycobacterium tuberculosis. 10.1186/s12916-016-0598-2

The blp Locus of Streptococcus pneumoniae Plays a Limited Role in the Selection of Strains That Can Cocolonize the Human Nasopharynx. 10.1128/AEM.01048-16

Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases. 10.1128/JCM.02993-14

DIAGNOSTIC AND CLINICAL IMPLICATIONS OF GENOTYPIC FLUOROQUINOLONE SUSCEPTIBILITY DETECTION FOR NEISSERIA GONORRHOEAE 10.1136/sextrans-2015-052270.104

Multi-serotype pneumococcal nasopharyngeal carriage prevalence in vaccine naïve Nepalese children, assessed using molecular serotyping. 10.1371/journal.pone.0114286

High multiple carriage and emergence of Streptococcus pneumoniae vaccine serotype variants in Malawian children. 10.1186/s12879-015-0980-2

A point mutation in cpsE renders Streptococcus pneumoniae nonencapsulated and enhances its growth, adherence and competence. 10.1186/s12866-014-0210-x

Genome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expression. 10.1186/1471-2164-14-710

A cross-sectional observational study of pneumococcal carriage in children, their parents, and older adults following the introduction of the 7-valent pneumococcal conjugate vaccine. 10.1097/MD.0000000000000335

Genome sequencing and characterization of an extensively drug-resistant sequence type 111 serotype O12 hospital outbreak strain of Pseudomonas aeruginosa. 10.1111/1469-0691.12528

Multiple Streptococcus pneumoniae serotypes in aural discharge samples from children with acute otitis media with spontaneous otorrhea. 10.1128/JCM.01303-13

Mycobacterium leprae genomes from a British medieval leprosy hospital: towards understanding an ancient epidemic. 10.1186/1471-2164-15-270

Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection. 10.1371/journal.pgen.1003868

Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization. 10.1093/cid/cis842

Rotating wall vessel exposure alters protein secretion and global gene expression in Staphylococcus aureus 10.1017/S1473550411000346

Resurgence of serotype 19F carriage in preschool children in Portugal in the context of continuing moderate conjugate pneumococcal vaccine uptake. 10.1093/cid/cit233

Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase. 10.1021/bi300645n

Pneumococcal sequence type replacement among American Indian children: a comparison of pre- and routine-PCV7 eras. 10.1016/j.vaccine.2011.11.004

Decrease in pneumococcal co-colonization following vaccination with the seven-valent pneumococcal conjugate vaccine. 10.1371/journal.pone.0030235

Comparative phylogenomics of Streptococcus pneumoniae isolated from invasive disease and nasopharyngeal carriage from West Africans. 10.1186/1471-2164-13-569

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus. 10.1186/1752-0509-5-68

Nontypeable pneumococcal isolates among navajo and white mountain apache communities: are these really a cause of invasive disease? 10.1093/infdis/jis307

Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates. 10.1099/mic.0.056580-0

The distribution of mobile genetic elements (MGEs) in MRSA CC398 is associated with both host and country. 10.1093/gbe/evr092

BμG@Sbase--a microbial gene expression and comparative genomic database. 10.1093/nar/gkr796

Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages. 10.1371/journal.pone.0011066

Influence of tigecycline on expression of virulence factors in biofilm-associated cells of methicillin-resistant Staphylococcus aureus. 10.1128/AAC.00155-09

Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation. 10.1093/gbe/evq031

The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori. 10.1186/1471-2180-10-106

Low-shear modelled microgravity alters expression of virulence determinants of Staphylococcus aureus 10.1016/j.actaastro.2009.06.007

Detection of large numbers of pneumococcal virulence genes in streptococci of the mitis group. 10.1128/JCM.01746-09

Two distinct clones of methicillin-resistant Staphylococcus aureus (MRSA) with the same USA300 pulsed-field gel electrophoresis profile: a potential pitfall for identification of USA300 community-associated MRSA. 10.1128/JCM.00934-09

The pneumococcal response to oxidative stress includes a role for Rgg. 10.1099/mic.0.028282-0

Effect of FliK mutation on the transcriptional activity of the sigma54 sigma factor RpoN in Helicobacter pylori. 10.1099/mic.0.026062-0

Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer. 10.1093/jac/dkp325

Empirical Bayesian models for analysing molecular serotyping microarrays. 10.1186/1471-2105-12-88

Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes. 10.1111/j.1462-2920.2011.02461.x

Improved detection of nasopharyngeal cocolonization by multiple pneumococcal serotypes by use of latex agglutination or molecular serotyping by microarray. 10.1128/JCM.00157-11

The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus. 10.1093/jac/dkr044

High levels of recombination among Streptococcus pneumoniae isolates from the Gambia. 10.1128/mBio.00222-11

Transcriptional profiling of XdrA, a new regulator of spa transcription in Staphylococcus aureus. 10.1128/JB.00491-10

Genetic variation in spatio-temporal confined USA300 community-associated MRSA isolates: a shift from clonal dispersion to genetic evolution? 10.1371/journal.pone.0016419

Multiple colonization with S. pneumoniae before and after introduction of the seven-valent conjugated pneumococcal polysaccharide vaccine. 10.1371/journal.pone.0011638

Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. 10.1074/jbc.M110.114793

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. 10.1371/journal.pmed.0050075

Characterization of two in vivo-expressed methyltransferases of the Mycobacterium tuberculosis complex: antigenicity and genetic regulation. 10.1099/mic.0.2007/014548-0

Genomic diversity among Beijing and non-Beijing Mycobacterium tuberculosis isolates from Myanmar. 10.1371/journal.pone.0001973

Transcriptional signature following inhibition of early-stage cell wall biosynthesis in Staphylococcus aureus. 10.1128/AAC.01309-08

Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever. 10.1128/AAC.00645-08

Mycobacterial cells have dual nickel-cobalt sensors: sequence relationships and metal sites of metal-responsive repressors are not congruent. 10.1074/jbc.M703451200

Comparative transcriptomics reveals key gene expression differences between the human and bovine pathogens of the Mycobacterium tuberculosis complex. 10.1099/mic.0.2007/009894-0

Discovery of Stable and Variable Differences in the Mycobacterium avium subsp. paratuberculosis Type I, II, and III Genomes by Pan-Genome Microarray Analysis (vol 75, pg 676, 2008) 10.1128/AEM.00293-09

Genome analysis shows a common evolutionary origin for the dominant strains of Mycobacterium tuberculosis in a UK South Asian community. 10.1016/j.tube.2007.05.017

Deletion of a previously uncharacterized flagellar-hook-length control gene fliK modulates the sigma54-dependent regulon in Campylobacter jejuni. 10.1099/mic.0.2007/007401-0

Quantification of global transcription patterns in prokaryotes using spotted microarrays. 10.1186/gb-2007-8-12-r265

Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains. 10.1128/JB.00664-06

Whole genome analysis using microarrays. 10.1007/978-1-59745-207-6_6

Discovery of stable and variable differences in the Mycobacterium avium subsp. paratuberculosis type I, II, and III genomes by pan-genome microarray analysis. 10.1128/AEM.01683-08

A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. 10.1186/1757-4749-1-25

Posttranscriptional regulation of flagellin synthesis in Helicobacter pylori by the RpoN chaperone HP0958. 10.1128/JB.00879-08

Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux. 10.1186/1471-2180-8-177

The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications. 10.1371/journal.pone.0004344

Genome analysis shows a common evolutionary origin for the dominant strains of Mycobacterium tuberculosis in a UK South Asian community (vol 87, pg 426, 2007) 10.1016/j.tube.2008.02.001

Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin. 10.1093/jac/dkn387

Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species. 10.1099/mic.0.28099-0

Construction and analysis of chromosomal Clostridium difficile mutants. 10.1111/j.1365-2958.2006.05315.x

The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as virulence genes: response. 10.1186/1471-2164-7-129

Application of comparative phylogenomics to study the evolution of Yersinia enterocolitica and to identify genetic differences relating to pathogenicity. 10.1128/JB.188.10.3645-3653.2006

Genomic diversity between strains of the same serotype and multilocus sequence type among pneumococcal clinical isolates. 10.1128/IAI.00079-06

Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source. 10.1073/pnas.0503252102

NssR, a member of the Crp-Fnr superfamily from Campylobacter jejuni, regulates a nitrosative stress-responsive regulon that includes both a single-domain and a truncated haemoglobin. 10.1111/j.1365-2958.2005.04723.x

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. 10.1128/IAI.74.1.88-98.2006

Campylobacter jejuni gene expression in the chick cecum: evidence for adaptation to a low-oxygen environment. 10.1128/IAI.73.8.5278-5285.2005

A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor (vol 56, pg 1274, 2005) 10.1111/j.1365-2958.2005.04719.x

Identification of genetic markers for Mycobacterium pinnipedii through genome analysis. 10.1016/j.femsle.2005.05.034

Design, validation, and application of a seven-strain Staphylococcus aureus PCR product microarray for comparative genomics. 10.1128/AEM.71.11.7504-7514.2005

Microarrays reveal that each of the ten dominant lineages of Staphylococcus aureus has a unique combination of surface-associated and regulatory genes. 10.1128/JB.188.2.669-676.2006

A novel CRP-dependent regulon controls expression of competence genes in Haemophilus influenzae. 10.1016/j.jmb.2005.01.012

Phenotypic and transcriptional characterization of the meningococcal PhoPQ system, a magnesium-sensing two-component regulatory system that controls genes involved in remodeling the meningococcal cell surface. 10.1128/JB.187.14.4967-4975.2005

DNA microarrays for virus detection in cases of central nervous system infection. 10.1128/JCM.42.12.5811-5818.2004

Explorative multifactor approach for investigating global survival mechanisms of Campylobacter jejuni under environmental conditions. 10.1128/AEM.71.4.2086-2094.2005

The influence of reduced oxygen availability on pathogenicity and gene expression in Mycobacterium tuberculosis. 10.1016/j.tube.2003.12.011

Gene expression profile of Mycobacterium tuberculosis in a non-replicating state. 10.1016/j.tube.2003.12.006

Genome structure in the vole bacillus, Mycobacterium microti, a member of the Mycobacterium tuberculosis complex with a low virulence for humans. 10.1099/mic.0.26660-0

Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms? 10.1016/j.tube.2003.12.010

Advanced significance analysis of microarray data based on weighted resampling: a comparative study and application to gene deletions in Mycobacterium bovis. 10.1093/bioinformatics/btg417

Microarray analysis of Mycobacterium microti reveals deletion of genes encoding PE-PPE proteins and ESAT-6 family antigens. 10.1016/j.tube.2003.12.002

Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis. 10.1101/gr.1507303

Genetic composition of Mycobacterium bovis BCG substrain sofia 10.1128/JCM.41.11.5349.2003

Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays. 10.1099/00221287-148-10-3129

The heat shock response of Mycobacterium tuberculosis: linking gene expression, immunology and pathogenesis. 10.1002/cfg.183

Construction of a Yersinia pestis microarray. 10.1007/0-306-48416-1_9

Separated at birth? Microarray analysis of two strikingly similar yersinia species. 10.1002/cfg.195

Microarrays for Microbes: the BmuG@S Approach. 10.1002/cfg.187

Microarray-based comparative genomics: genome plasticity in Mycobacterium bovis. 10.1002/cfg.182

BmuG@Sbase--a microarray database and analysis tool. 10.1002/cfg.197

Enhanced gene replacement in mycobacteria. 10.1099/13500872-145-3-519

Whole genome comparison of Campylobacter jejuni human isolates using a low-cost microarray reveals extensive genetic diversity. 10.1101/gr.185801

Evaluation of pneumococcal serotyping in nasopharyngeal carriage isolates by latex agglutination, whole genome sequencing (PneumoCaT) and DNA microarray in a high pneumococcal carriage prevalence population in Malawi. 10.1128/JCM.02103-20

Insights into pneumococcal pneumonia using lung aspirates and nasopharyngeal swabs collected from pneumonia patients in The Gambia. 10.1093/infdis/jiaa186

Persistent Circulation of Vaccine Serotypes and Serotype Replacement After 5 Years of Infant Immunization With 13-Valent Pneumococcal Conjugate Vaccine in the United Kingdom. 10.1093/infdis/jiz178

Impact of 13-Valent Pneumococcal Conjugate Vaccine on Colonization and Invasive Disease in Cambodian Children. 10.1093/cid/ciz481

Pneumococcal carriage, density, and co-colonization dynamics: A longitudinal study in Indonesian infants. 10.1016/j.ijid.2019.06.024

Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010-2017. 10.1093/infdis/jiz034

Pneumococcal carriage in children in Ulaanbaatar, Mongolia before and one year after the introduction of the 13-valent pneumococcal conjugate vaccine. 10.1016/j.vaccine.2019.05.078

The Challenges of Using Oropharyngeal Samples To Measure Pneumococcal Carriage in Adults. 10.1128/mSphere.00478-20

Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System. 10.1128/mBio.00445-20

Identification of Streptococcus pneumoniae by a real-time PCR assay targeting SP2020. 10.1038/s41598-019-39791-1

High levels of recombination among Streptococcus pneumoniae isolates from the Gambia. 10.1128/mBio.00040-11

A Hidden Markov model web application for analysing bacterial genomotyping DNA microarray experiments. 10.2165/00822942-200605040-00003

Using a DNA microarray to investigate the distribution of insect virulence factors in strains of photorhabdus bacteria. 10.1128/jb.185.15.4648-4656.2003

A two-component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae. 10.1111/j.1365-2958.2003.03917.x

Use of genome level-informed PCR as a new investigational approach for analysis of outbreak-associated Mycobacterium tuberculosis isolates. 10.1128/jcm.42.5.1890-1896.2004

The majority of inducible DNA repair genes in Mycobacterium tuberculosis are induced independently of RecA. 10.1046/j.1365-2958.2003.03765.x

Genomic analysis of Mycobacterium tuberculosis complex strains used for production of purified protein derivative. 10.1128/jcm.41.8.3929-3932.2003

Analysis of whole-genome microarray replicates using mixed models. 10.1093/bioinformatics/19.1.53

Marsollier Laurent

Laurent Marsollier

ORCID: 0000-0001-5497-5995

High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice. 10.7717/peerj.9659

Genome-wide association study of Buruli ulcer in rural Benin highlights role of two LncRNAs and the autophagy pathway. 10.1038/s42003-020-0920-6

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model. 10.1128/iai.00753-19

Senegal, a new potential endemic country for Buruli ulcer? 10.1016/j.ijid.2019.09.020

Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls. 10.3390/toxins11090516

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters. 10.3389/fphar.2019.00378

Microdeletion on chromosome 8p23.1 in a familial form of severe Buruli ulcer. 10.1371/journal.pntd.0006429

The potent effect of mycolactone on lipid membranes. 10.1371/journal.ppat.1006814

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. 10.3390/toxins9070227

Mouse model of colonization of the digestive tract with Acinetobacter baumannii and subsequent pneumonia. 10.2217/fmb-2016-0203

Ecology and Feeding Habits Drive Infection of Water Bugs with Mycobacterium ulcerans. 10.1007/s10393-017-1228-y

Draft Genome Sequence of Mycobacterium ulcerans S4018 Isolated from a Patient with an Active Buruli Ulcer in Benin, Africa. 10.1128/genomea.00248-17

An Optimized Method for Extracting Bacterial RNA from Mouse Skin Tissue Colonized by Mycobacterium ulcerans. 10.3389/fmicb.2017.00512

Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa. 10.1093/gbe/evx003

Deforestation-driven food-web collapse linked to emerging tropical infectious disease, Mycobacterium ulcerans. 10.1126/sciadv.1600387

Chitin promotes Mycobacterium ulcerans growth. 10.1093/femsec/fiw067

Molecular Species Delimitation and Morphology of Aquatic and Sub-Aquatic Bugs (Heteroptera) in Cameroon. 10.1371/journal.pone.0154905

FVB/N Mice Spontaneously Heal Ulcerative Lesions Induced by Mycobacterium ulcerans and Switch M. ulcerans into a Low Mycolactone Producer. 10.4049/jimmunol.1502194

[Mycolactone: the amazing analgesic mycobacterial toxin]. 10.1051/medsci/20163202007

Clinical Features of Spontaneous Partial Healing During Mycobacterium ulcerans Infection. 10.1093/ofid/ofw013

Seasonal Patterns of Buruli Ulcer Incidence, Central Africa, 2002-2012. 10.3201/eid2108.141336

Mycobacterium ulcerans dynamics in aquatic ecosystems are driven by a complex interplay of abiotic and biotic factors. 10.7554/elife.07616

Development of a dry-reagent-based qPCR to facilitate the diagnosis of Mycobacterium ulcerans infection in endemic countries. 10.1371/journal.pntd.0003606

Extrahuman epidemiology of Acinetobacter baumannii in Lebanon. 10.1128/aem.03824-14

Mycobacterium ulcerans disease (Buruli ulcer) in Mali: A new potential African endemic country. 10.2340/00015555-1942

Buruli ulcer in South Western Nigeria: a retrospective cohort study of patients treated in Benin. 10.1371/journal.pntd.0003443

[Detection of the IS2404 insertion sequence and ketoreductase produced by Mycobacterium ulcerans in the aquatic Heteroptera in the health districts of Dabou and Tiassalé in Côte d'Ivoire]. 10.1684/mst.2014.0363

Topography and land cover of watersheds predicts the distribution of the environmental pathogen Mycobacterium ulcerans in aquatic insects. 10.1371/journal.pntd.0003298

Defining and targeting high-risk populations in Buruli ulcer--authors' reply. 10.1016/s2214-109x(14)70312-2

Buruli ulcer acquired in Mali: a rare and atypical situation. 10.1016/j.tmaid.2014.09.009

Findings in patients from Benin with osteomyelitis and polymerase chain reaction-confirmed Mycobacterium ulcerans infection. 10.1093/cid/ciu584

HIV infection and Buruli ulcer in Africa. 10.1016/s1473-3099(14)70882-5

Clinical epidemiology of laboratory-confirmed Buruli ulcer in Benin: a cohort study. 10.1016/s2214-109x(14)70223-2

Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways. 10.1016/j.cell.2014.04.040

A case of guilt by association: Water bug bite incriminated in M. ulcerans infection. 10.1016/j.ijmyco.2014.01.004

Buruli ulcer disease in Republic of the Congo. 10.3201/eid2006.131498

Mycobacterium ulcerans ecological dynamics and its association with freshwater ecosystems and aquatic communities: results from a 12-month environmental survey in Cameroon. 10.1371/journal.pntd.0002879

First detection of Mycobacterium ulcerans DNA in environmental samples from South America. 10.1371/journal.pntd.0002660

[Buruli ulcer: a dynamic transversal research model performed through the international network of Pasteur Institutes]. 10.1051/medsci/20132910021

Photodegradation of the Mycobacterium ulcerans toxin, mycolactones: considerations for handling and storage. 10.1371/journal.pone.0033600

Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon. 10.1371/journal.pntd.0001392

Geographic expansion of Buruli ulcer disease, Cameroon. 10.3201/eid1703.091859

Oral treatment for Mycobacterium ulcerans infection: results from a pilot study in Benin. 10.1093/cid/ciq072

Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics. 10.1371/journal.pntd.0000872

Use of fine-needle aspiration for diagnosis of Mycobacterium ulcerans infection. 10.1128/jcm.00558-10

Buruli ulcer, Central African Republic. 10.3201/eid1604.090195

Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer. 10.1371/journal.pntd.0000553

High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. 10.1371/journal.ppat.1000645

Buruli ulcer in long-term traveler to Senegal. 10.3201/eid1501.080123

Optimized method for preparation of DNA from pathogenic and environmental mycobacteria. 10.1128/aem.01358-08

Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv. 10.1074/jbc.m802115200

Comprehensive proteome analysis of Mycobacterium ulcerans and quantitative comparison of mycolactone biosynthesis. 10.1002/pmic.200701018

Risk factors for buruli ulcer: a case control study in Cameroon. 10.1371/journal.pntd.0000101

[Aquatic insects and transmission of Mycobacterium ulcerans]. 10.1051/medsci/20072367572

Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis. 10.1371/journal.ppat.0030062

Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva. 10.1371/journal.pmed.0040064

Early trafficking events of Mycobacterium ulcerans within Naucoris cimicoides. 10.1111/j.1462-5822.2006.00790.x

Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence. 10.1128/jb.00631-06

Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer. 10.1016/j.micinf.2006.03.009

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. 10.1128/iai.74.1.88-98.2006

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin. 10.1111/j.1462-5822.2005.00546.x

Colonization of the salivary glands of Naucoris cimicoides by Mycobacterium ulcerans requires host plasmatocytes and a macrolide toxin, mycolactone. 10.1111/j.1462-5822.2005.00521.x

[Diagnosis of Mycobacterium ulcerans infections in French Guiana]. 10.1016/s0755-4982(04)98974-9

Aquatic snails, passive hosts of Mycobacterium ulcerans. 10.1128/aem.70.10.6296-6298.2004

Aquatic plants stimulate the growth of and biofilm formation by Mycobacterium ulcerans in axenic culture and harbor these bacteria in the environment. 10.1128/aem.70.2.1097-1103.2004

Susceptibility of Mycobacterium ulcerans to a combination of amikacin/rifampicin. 10.1016/s0924-8579(03)00240-1

[Ecology and transmission of Mycobacterium ulcerans]. 10.1016/s0369-8114(03)00151-2

Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice. 10.1128/aac.47.4.1228-1232.2003

Aquatic insects as a vector for Mycobacterium ulcerans. 10.1128/aem.68.9.4623-4628.2002