Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant
Brodin, P. Eiglmeier, K. Marmiesse, M. Billault, A. Garnier, T. Niemann, S. Cole, S. T. Brosch, R.
Infection and immunity, 2002-10
https://doi.org/10.1128/iai.70.10.5568-5578.2002
Priscille Brodin
Brodin Priscille
ORCID: 0000-0003-0991-7344
Email: priscille.brodin@inserm.fr
How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011
Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227 10.3390/toxins9070227.
Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections 10.2217/nnm-2016-0364
Cyclodextrin-based nanocarriers containing a synergic drug combination: a potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030 10.1016/j.ijpharm.2017.05.030.
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z
Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005 10.1016/j.drudis.2017.05.005.
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535
Impact of pe_ pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis 10.3389/fcimb.2017.00137
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129 10.1002/cyto.a.23129.
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5
Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization 10.1016/j.str.2016.07.009
Mycolactone The amazing analgesic mycobacterial toxin 10.1051/medsci/20163202007
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650
High content screening in chemical biology: overview and main challenges 10.1051/medsci/20153102016
High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis 10.1128/aac.03705-14
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438
Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15
Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays 10.1007/978-1-4939-2450-9_24
A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening 10.3791/51114
Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/jm500422b
Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040
Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022
A novel specific edge effect correction method for RNA interference screenings 10.1093/bioinformatics/btr648
Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779
Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u
The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence 10.1371/journal.pone.0047573
Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis 10.1371/journal.pone.0026675
Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200076a
High-content screening in infectious diseases 10.1016/j.cbpa.2011.05.023
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ 10.1099/mic.0.038133-0
High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100
High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery 10.4155/fmc.10.223
Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting 10.1016/j.biomaterials.2009.09.044
Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure 10.1177/1087057108328762
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis 10.1126/science.1171583
High Content Screening Identifies Decaprenyl-Phosphoribose 2 ' Epimerase as a Target for Intracellular Antimycobacterial Inhibitors 10.1371/journal.ppat.1000645
Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507
Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033
Aquatic insects and transmission of Mycobacterium ulcerans 10.1051/medsci/20072367572
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 10.1128/jb.00469-07
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis 10.1371/journal.ppat.0030062
Protection against mycobacterium ulcerans lesion development by exposure to aquatic insect saliva 10.1371/journal.pmed.0040064
Support vector machines for automatic detection of tuberculosis bacteria in confocal microscopy images 10.1109/isbi.2007.356794
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues 10.1016/j.bmc.2006.12.009
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis 10.1128/iai.74.4.2128-2137.2006
Benzofuro 3,2-f 1 benzopyrans: A new class of antitubercular agents 10.1016/j.bmc.2006.03.033
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/iai.74.1.88-98.2006
High frequency of CD4(+) T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection 10.1128/iai.02086-05
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence 10.1128/jb.00631-06
Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis 10.1016/j.tube.2004.09.009
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200
Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics 10.1099/mic.0.27799-0
Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions 10.1016/j.jmb.2005.05.049
Tuberculosis: from genome to vaccine 10.1586/14760584.4.4.541
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6 10.1128/iai.72.4.2170-2176.2004
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468
ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex 10.1099/mic.0.26662-0
CD8(+)-T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family 10.1128/iai.71.12.7173-7177.2003
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/nm859
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant 10.1128/iai.70.10.5568-5578.2002
Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides 10.1021/bi015732y
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x
6-Oxocytidine containing oligonucleotides inhibit the HIV-1 integrase in vitro 10.1081/ncn-100002322
Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase 10.1021/bi000398b
Inhibition of the human immunodeficiency virus type 1 DNA integration by modified oligonucleotides 10.1023/a:1026631910681
Branched oligonucleotide-intercalator conjugate forming a parallel stranded structure inhibits HIV-1 integrase 10.1016/s0014-5793(99)01350-2
Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides 10.1080/07328319908044831
Optimization of alternate-strand triple helix formation at the 5 '-TpA-3 ' and 5 '-ApT-3 ' junctions 10.1093/nar/27.15.3029
A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus 10.1074/jbc.272.25.16010
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371 10.15252/embr.201744371.
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017 10.1016/j.mib.2017.11.017.
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101 10.1016/j.celrep.2017.08.101.
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114 10.1073/pnas.1707840114.
Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry 10.1128/jvi.01982-17
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025
Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation 10.3389/fimmu.2018.00086
Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis 10.1128/aac.00359-18
The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101
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Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation 10.1074/mcp.RA119.001316
Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902
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Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258
Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication 10.1128/jvi.02009-18
A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J
Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls 10.3390/toxins11090516
Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies. 10.3389/fimmu.2020.569127
Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity. 10.1021/acsinfecdis.9b00277
Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds. 10.1371/journal.pone.0227224
Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis. 10.1016/j.vaccine.2019.11.085
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551
Worms' Antimicrobial Peptides. 10.3390/md17090512
Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. 10.1371/journal.pone.0198226
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570
Cell microbiology interview 10.1111/cmi.13288
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505
Nathalie deboosere
deboosere Nathalie
ORCID: 0000-0002-2873-5485
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 10.1016/j.celrep.2017.08.101
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. 10.3390/toxins9070227
Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. 10.1021/acschembio.7b00091
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. 10.1111/cmi.12619
A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114
Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces. 10.1016/j.fm.2012.04.007
Viral elution and concentration method for detection of influenza A viruses in mud by real-time RT-PCR. 10.1016/j.jviromet.2011.10.013
Comparison of chlorine and peroxyacetic-based disinfectant to inactivate Feline calicivirus, Murine norovirus and Hepatitis A virus on lettuce. 10.1016/j.ijfoodmicro.2011.08.011
Direct detection of highly pathogenic avian influenza A/H5N1 virus from mud specimens. 10.1016/j.jviromet.2011.06.002
Development and validation of a concentration method for the detection of influenza a viruses from large volumes of surface water. 10.1128/aem.02484-10
A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries. 10.1016/j.fm.2010.05.018
Assessment of the removal and inactivation of influenza viruses H5N1 and H1N1 by drinking water treatment. 10.1016/j.watres.2010.01.013
Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables. 10.1016/j.ijfoodmicro.2005.11.007
Modelling effect of physical and chemical parameters on heat inactivation kinetics of hepatitis A virus in a fruit model system. 10.1016/j.ijfoodmicro.2003.10.015
Host-pathogen systems for early drug discovery against tuberculosis. 10.1016/j.mib.2017.11.017
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids. 10.1073/pnas.1707840114
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. 10.1038/s41598-017-11843-4
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages. 10.1016/j.chom.2017.07.020
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-017-05453-3
Host-directed therapies offer novel opportunities for the fight against tuberculosis. 10.1016/j.drudis.2017.05.005
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs. 10.1016/j.ijpharm.2017.05.030
Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis. 10.3389/fcimb.2017.00137
Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections. 10.2217/nnm-2016-0364
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. 10.1126/science.aag1006
How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 10.1007/s00401-016-1652-z
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535
Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization. 10.1016/j.str.2016.07.009
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro. 10.1007/s00705-016-2771-5
[Mycolactone: the amazing analgesic mycobacterial toxin]. 10.1051/medsci/20163202007
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. 10.1039/c5ob02630j
Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action. 10.1128/jvi.01473-15
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system. 10.1016/j.vaccine.2015.03.083
Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo. 10.1371/journal.ppat.1004650
[High content screening in chemical biology: overview and main challenges]. 10.1051/medsci/20153102016
Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays. 10.1007/978-1-4939-2450-9_24
2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1. 10.1021/cb5007163
High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis. 10.1128/aac.03705-14
Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways. 10.1016/j.cell.2014.04.040
Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches. 10.1021/jm500422b
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262
The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence. 10.1371/journal.pone.0047573
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors. 10.1021/jm200825u
A novel specific edge effect correction method for RNA interference screenings. 10.1093/bioinformatics/btr648
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis. 10.1371/journal.pone.0026675
High-content screening in infectious diseases. 10.1016/j.cbpa.2011.05.023
Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors. 10.1021/jm200076a
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. 10.1371/journal.ppat.1001100
High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery. 10.4155/fmc.10.223
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ. 10.1099/mic.0.038133-0
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. 10.1371/journal.ppat.1000645
Systematic genetic nomenclature for type VII secretion systems. 10.1371/journal.ppat.1000507
Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. 10.1016/j.biomaterials.2009.09.044
Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. 10.1126/science.1171583
Automated high-throughput siRNA transfection in raw 264.7 macrophages: a case study for optimization procedure. 10.1177/1087057108328762
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. 10.1371/journal.ppat.0040033
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. 10.1128/jb.00469-07
[Aquatic insects and transmission of Mycobacterium ulcerans]. 10.1051/medsci/20072367572
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis. 10.1371/journal.ppat.0030062
Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva. 10.1371/journal.pmed.0040064
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues. 10.1016/j.bmc.2006.12.009
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence. 10.1128/jb.00631-06
High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection. 10.1128/iai.02086-05
Benzofuro[3,2-f][1]benzopyrans: a new class of antitubercular agents. 10.1016/j.bmc.2006.03.033
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis. 10.1128/iai.74.4.2128-2137.2006
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. 10.1128/iai.74.1.88-98.2006
Tuberculosis: from genome to vaccine. 10.1586/14760584.4.4.541
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity. 10.1074/jbc.m503515200
Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics. 10.1099/mic.0.27799-0
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. 10.1016/j.tube.2004.09.009
ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens. 10.1086/421468
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6. 10.1128/iai.72.4.2170-2176.2004
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex. 10.1099/mic.0.26662-0
CD8+-T-cell responses of Mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family. 10.1128/iai.71.12.7173-7177.2003
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. 10.1038/nm859
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. 10.1046/j.1365-2958.2002.03237.x
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. 10.1128/iai.70.10.5568-5578.2002
Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides. 10.1021/bi015732y
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551
Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483
Stefan Niemann
Niemann Stefan
ORCID: 0000-0002-6604-0684
A snapshot of the predominant single nucleotide polymorphism cluster groups of Mycobacterium tuberculosis clinical isolates in Delhi, India 10.1016/j.tube.2016.07.007
Mycobacterium abscessus, a taxonomic puzzle 10.1099/ijsem.0.002457
rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains 10.1128/AAC.06227-11
Evaluation and strategy for use of MIRU-VNTRplus, a multifunctional database for online analysis of genotyping data and phylogenetic identification of Mycobacterium tuberculosis complex isolates 10.1128/JCM.00540-08
Whole genome sequencing for M/XDR tuberculosis surveillance and for resistance testing 10.1016/j.cmi.2016.10.014
Impact of genetic diversity on the biology of Mycobacterium tuberculosis complex strains 10.1128/microbiolspec.TBTB2-0022-2016
Advances in the molecular epidemiology of tuberculosis,Fortschritte in der molekularen epidemiologie der tuberkulose 10.1007/s10405-013-0694-3
Erratum: Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis (Nature Communications (2015) 6 (10063) DOI: 10.1038/ncomms10063) 10.1038/ncomms11465
Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development 10.1371/journal.pone.0214088
Consensus numbering system for the rifampicin resistance-associated rpoB gene mutations in pathogenic mycobacteria 10.1016/j.cmi.2016.09.006
Tuberculosis outbreak in 13 people in Saxony-Anhalt: Indications of an infection chain by spoligotyping,Tuberkulose-ausbruch bei 13 personen in Sachsen-Anhalt: Hinweis auf die infektkette durch spoligotyping 10.1055/S-0031-1285862
The Beijing genotype and drug resistant tuberculosis in the Aral Sea region of Cental Asia 10.1186/1465-9921-6-134
Characteristics of drug-resistant tuberculosis in Abkhazia (Georgia), a high-prevalence area in Eastern Europe 10.1016/j.tube.2009.04.002
Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study 10.1016/S1473-3099(18)30073-2
Online tools for polyphasic analysis of Mycobacterium tuberculosis complex genotyping data: Now and next 10.1016/j.meegid.2012.01.021
Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints 10.1371/journal.pone.0007407
Reply: Call for regular susceptibility testing of bedaquiline and delamanid 10.1164/rccm.201605-1065LE
Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: Comparison of automated analysis tools 10.1038/srep46327
Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: A prospective study 10.1016/S2213-2600(15)00466-X
Whole genome sequencing reveals complex evolution patterns of multidrug-resistant Mycobacterium tuberculosis Beijing strains in patients 10.1371/journal.pone.0082551
Mycobacterium bovis persistence in two different captive wild animal populations in Germany: A longitudinal molecular epidemiological study revealing pathogen transmission by whole-genome sequencing 10.1128/JCM.00302-18d
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis 10.1038/nature13591
Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex 10.1128/AAC.00555-11
Lab-on-chip-based platform for fast molecular diagnosis of multidrug-resistant tuberculosis 10.1128/JCM.01824-15
Emergence of extensive drug resistance during treatment for multidrug-resistant tuberculosis 10.1056/NEJMc0805644
Delamanid susceptibility testing of Mycobacterium tuberculosis using the resazurin microtitre assay and the BACTEC™ MGIT™ 960 system 10.1093/jac/dkw044
CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population 10.1371/journal.pone.0006307
Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates 10.1016/j.meegid.2011.06.011
No Evidence for Acquired Mutations Associated with Cytochrome bc1 Inhibitor Resistance in 13,559 Clinical Mycobacterium tuberculosis Complex Isolates 10.1128/AAC.01317-18
Detection of drug-resistant tuberculosis by xpert MTB/RIF in Swaziland 10.1056/NEJMc1413930
Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment 10.1128/AAC.00050-09
New developments in molecular epidemiology of tuberculosis,Neue Entwicklungen in der molekularen Epidemiologie der Tuberkulose 10.1007/s10405-010-0400-7
Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays 10.1128/AAC.02169-16
A novel multiplex real-time pcr for the identification of mycobacteria associated with zoonotic tuberculosis 10.1371/journal.pone.0023481
Current issues of latent tuberculosis infection and contact investigation,Aktuelle Aspekte zur latenten Tuberkuloseinfektion und zur Umgebungsuntersuchung 10.5414/ATX02145
MIRU-VNTRplus: A web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria 10.1093/nar/gkq351
Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains 10.1371/journal.ppat.1000577
A joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: Lessons learnt 10.2807/1560-7917.ES.2017.22.2.30439
Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee 10.3201/eid1906.121012
Mycobacterium tuberculosis pyrazinamide resistance determinants: A multicenter study 10.1128/mBio.01819-14
Revised interpretation of the hain lifescience genotype mtbc to differentiate mycobacterium canettii and members of the mycobacterium tuberculosis complex 10.1128/AAC.00159-19
New Mycobacterium tuberculosis complex sublineage, Brazzaville, Congo 10.3201/eid2303.160679
Whole-genome-based Mycobacterium tuberculosis surveillance: A standardized, portable, and expandable approach 10.1128/JCM.00567-14
Transmission dynamics of pulmonary tuberculosis between autochthonous and immigrant sub-populations 10.1186/1471-2334-9-197
High genetic diversity among Mycobacterium tuberculosis complex strains from Sierra Leone 10.1186/1471-2180-8-103
Significance of mutations in embB Codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates 10.1128/AAC.50.5.1900-1902.2006
Evaluation of molecular-beacon, TaqMan, and fluorescence resonance energy transfer probes for detection of antibiotic resistance-conferring single nucleotide polymorphisms in mixed Mycobacterium tuberculosis DNA extracts 10.1128/JCM.00225-06
First worldwide proficiency study on variable-number tandem-repeat typing of Mycobacterium tuberculosis complex strains 10.1128/JCM.00607-11
Special Issue on Molecular evolution, epidemiology and pathogenesis of Mycobacterium tuberculosis and other mycobacteria 10.1016/j.meegid.2012.02.016
Molecular epidemiology of drug-resistant tuberculosis in Hungary 10.1128/JCM.01254-06
embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation 10.1093/jac/dkq120
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase 10.1038/s41598-018-33731-1
Joint Statement on the New WHO Recommendations for Treatment of Multidrug- and Rifampicin-Resistant Tuberculosis,Gemeinsame Stellungnahme zur neuen Empfehlung der WHO zur Behandlung der multiresistenten und Rifampicin-resistenten Tuberkulose 10.1055/a-0880-9987
Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance 10.1128/AAC.01575-17
Replacing reverse line blot hybridization spoligotyping of the Mycobacterium tuberculosis complex 10.1128/JCM.02299-09
Risk of tuberculosis transmission among healthcare workers 10.1183/23120541.00161-2017
Rapid detection of Mycobacterium tuberculosis Beijing genotype strains by real-time PCR 10.1128/JCM.44.2.302-306.2006
Mycobacterium tuberculosis Beijing lineage favors the spread of multidrug-resistant tuberculosis in the Republic of Georgia 10.1128/JCM.00715-10
First Molecular Epidemiology Study of Mycobacterium tuberculosis in Kiribati 10.1371/journal.pone.0055423
High resolution discrimination of clinical mycobacterium tuberculosis complex strains based on single nucleotide polymorphisms 10.1371/journal.pone.0039855
Second worldwide proficiency study on variable number of tandem repeats typing of Mycobacterium tuberculosis complex 10.5588/ijtld.13.0531
Characterization of Mycobacterium caprae isolates from Europe by mycobacterial interspersed repetitive unit genotyping 10.1128/JCM.43.10.4984-4992.2005
Isoniazid resistance in mycobacterium tuberculosis is a heterogeneous phenotype composed of overlapping mic distributions with different underlying resistance mechanisms 10.1128/AAC.00092-19
Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved 10.1038/ng.590
Mycobacterium tuberculosis drug resistance, Ghana [7] 10.3201/eid1207.051028
Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones: results from a multicountry surveillance project 10.1016/S1473-3099(16)30190-6
IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB 10.1371/journal.pone.0005420
Genetic diversity within Mycobacterium tuberculosis complex impacts on the accuracy of genotypic pyrazinamide drug-susceptibility assay 10.1016/j.tube.2014.04.002
Importance of the genetic diversity within the Mycobacterium tuberculosis complex for the development of novel antibiotics and diagnostic tests of drug resistance 10.1128/AAC.01641-12
The role of IS6110 in micro- and macroevolution of Mycobacterium tuberculosis lineage 2 10.1016/j.ympev.2019.106559
Tracing Mycobacterium tuberculosis transmission by whole genome sequencing in a high incidence setting: A retrospective population-based study in East Greenland 10.1038/srep33180
Pyrazinamide resistance in multidrug-resistant strains of Mycobacterium tuberculosis isolated in Abkhazia [2] 10.1179/joc.2007.19.1.106
MTBseq: A comprehensive pipeline for whole genome sequence analysis of Mycobacterium tuberculosis complex isolates 10.7717/peerj.5895
Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis 10.1038/ncomms10063
Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis 10.1128/JCM.01392-06
Unequal distribution of resistance-conferring mutations among Mycobacterium tuberculosis and Mycobacterium africanum strains from Ghana 10.1016/j.ijmm.2010.04.019
SNP-IT tool for identifying subspecies and associated lineages of Mycobacterium tuberculosis complex 10.3201/eid2503.180894
Harmonized Genome Wide Typing of Tubercle Bacilli Using a Web-Based Gene-By-Gene Nomenclature System 10.1016/j.ebiom.2018.07.030
Whole genome sequencing of Mycobacterium tuberculosis for detection of recent transmission and tracing outbreaks: A systematic review 10.1016/j.tube.2016.02.009
Drug susceptibility profiles of pulmonary Mycobacterium tuberculosis isolates from patients in informal urban settlements in Nairobi, Kenya 10.1186/s12879-016-1920-5
Single-nucleotide polymorphisms in Rv2629 are specific for mycobacterium tuberculosis genotypes Beijing and Ghana but Not associated with rifampin resistance 10.1128/JCM.01237-08
High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography 10.1371/journal.pbio.0060311
Outbreak of multidrug-resistant tuberculosis in South Africa undetected by WHO-endorsed commercial tests: an observational study 10.1016/S1473-3099(18)30496-1
High interlaboratory reproducibility and accuracy of next-generation-sequencing-based bacterial genotyping in a ring trial 10.1128/JCM.02242-16
Phylogenetic polymorphisms in antibiotic resistance genes of the mycobacterium tuberculosis complex 10.1093/jac/dkt535
Tuberculosis treatment outcome and drug resistance in lambaréné, Gabon: A prospective cohort study 10.4269/ajtmh.15-0668
Assessment of an optimized mycobacterial interspersed repetitive-unit- variable-number tandem-repeat typing system combined with spoligotyping for population-based molecular epidemiology studies of tuberculosis 10.1128/JCM.01393-06
Application of machine learning techniques to tuberculosis drug resistance analysis 10.1093/bioinformatics/bty949
Aortic endograft infection with mycobacterium chimaera and Granulicatella adiacens, Switzerland, 2014 10.3201/eid2409.180247
Direct DNA extraction from Mycobacterium tuberculosis frozen stocks as a reculture-independent approach to whole-genome sequencing 10.1128/JCM.00662-15
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages 10.1038/ng.3704
Tuberculosis ethambutol resistance: Concordance between phenotypic and genotypic test results 10.1016/j.tube.2009.09.001
Ascertaining in vivo virulence of Mycobacterium tuberculosis lineages in patients in Mbeya, Tanzania 10.5588/ijtld.14.0403
No associations of human pulmonary tuberculosis with Sp110 variants. 10.1136/jmg.2005.037960
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis 10.1016/S2213-2600(17)30079-6
Landouzy septicemia (sepsis tuberculosa acutissima) due to Mycobacterium microti in an immunocompetent man 10.1007/s15010-005-5075-3
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans 10.1038/ng.2744
Chasing Koch's chimera 10.1016/S1473-3099(13)70041-0
Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies 10.1371/journal.pone.0007815
Erratum: Rapid detection of Mycobacterium tuberculosis Beijing genotype strains by real-time PCR (Journal of Clinical Microbiology (2006) 44, 2 (302-306)) 10.1128/JCM.01491-06
Tracing the spread of clostridium difficile ribotype 027 in Germany based on bacterial genome sequences 10.1371/journal.pone.0139811
Prediction of susceptibility to first-line tuberculosis drugs by DNA sequencing 10.1056/NEJMoa1800474
TB sequel: Incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB - A study protocol 11 Medical and Health Sciences 1117 Public Health and Health Services 10.1186/s12890-018-0777-3
Mycobacterium tuberculosis wears what it eats 10.1016/j.chom.2010.06.002
Rapid Microarray-Based Detection of Rifampin, Isoniazid, and Fluoroquinolone Resistance in Mycobacterium tuberculosis by Use of a Single Cartridge 10.1128/JCM.01249-17
Molecular drug susceptibility testing and strain typing of tuberculosis by DNA hybridization 10.1371/journal.pone.0212064
Impact of fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824 10.1128/AAC.05500-11
Variant G57E of Mannose Binding Lectin associated with protection against tuberculosis caused by mycobacterium africanum but not by M. tuberculosis 10.1371/journal.pone.0020908
Origin, spread and demography of the Mycobacterium tuberculosis complex 10.1371/journal.ppat.1000160
In vivo virulence of Mycobacterium tuberculosis depends on a single homologue of the LytR-CpsA-Psr proteins 10.1038/s41598-018-22012-6
Mycobacterium canettii is intrinsically resistant to both pyrazinamide and pyrazinoic acid 10.1093/jac/dkt042
Multiplex detection of extensively drug resistant tuberculosis using binary deoxyribozyme sensors 10.1016/j.bios.2017.02.051
Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues 10.1038/s41579-019-0214-5
A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study 10.1016/S1473-3099(18)30004-5
Rapid microarray-based assay for detection of pyrazinamide resistant Mycobacterium tuberculosis 10.1016/j.diagmicrobio.2018.12.011
The validity of Mycobacterium tuberculosis complex species identification. Comments on the article: "Differentiation of species within the Mycobacterium tuberculosis complex by molecular techniques",Sobre la validez de la identificación de especies del complejo Mycobacterium tuberculosis. Comentarios al artículo: « aplicación de métodos moleculares para la identificación de las especies del complejo Mycobacterium tuberculosis» 10.1016/j.eimc.2010.10.008
Comparative genomics of Mycobacterium africanum Lineage 5 and Lineage 6 from Ghana suggests distinct ecological niches 10.1038/s41598-018-29620-2
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis 10.1093/hmg/ddm378
Nosocomial transmission of multidrug-resistant tuberculosis 10.5588/ijtld.15.0327
Clade-specific virulence patterns of Mycobacterium tuberculosis complex strains in human primary macrophages and aerogenically infected mice 10.1128/mBio.00250-13
Whole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular Epidemiological Study 10.1371/journal.pmed.1001387
Negative and positive predictive value of a whole-blood interferon-γ release assay for developing active tuberculosis: An update 10.1164/rccm.201006-0974OC
Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea 10.1186/1471-2180-12-191
What is resistance? Impact of phenotypic versus molecular drug resistance testing on therapy for multi-and extensively drug-resistant tuberculosis 10.1128/AAC.01550-17
Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis 10.1111/joim.12780
Novel rapid PCR for the detection of Ile491Phe rpoB mutation of Mycobacterium tuberculosis, a rifampicin-resistance-conferring mutation undetected by commercial assays 10.1016/j.cmi.2016.12.009
Treatment of tuberculosis in a region with high drug resistance: Outcomes, drug resistance amplification and re-infection 10.1371/journal.pone.0023081
Whole genome sequencing of tuberculosis: Application for molecular epidemiology and diagnostics,Gesamtgenomsequenzierung der Tuberkulose: Anwendungen für molekulare Epidemiologie und Diagnostik 10.1007/s10405-017-0156-4
An application of competitive reporter monitored amplification (CMA) for rapid detection of single nucleotide polymorphisms (SNPs) 10.1371/journal.pone.0183561
Mycobacterium tuberculosis complex genetic diversity: Mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology 10.1186/1471-2180-6-23
Multicentre study to establish interpretive criteria for clofazimine drug susceptibility testing 10.5588/ijtld.18.0417
Predictive value of a whole blood IFN-γ assay for the development of active tuberculosis disease after recent infection with Mycobacterium tuberculosis 10.1164/rccm.200711-1613OC
Predominant Mycobacterium tuberculosis families and high rates of recent transmission among new cases are not associated with primary multidrug resistance in Lima, Peru 10.1128/JCM.03585-14
Mycobacterium tuberculosis embB codon 306 mutations confer moderately increased resistance to ethambutol in vitro and in vivo 10.1128/AAC.00007-10
Tuberculous lymphadenitis in Ethiopia predominantly caused by strains belonging to the Delhi/CAS lineage and newly identified Ethiopian clades of the mycobacterium tuberculosis complex 10.1371/journal.pone.0137865
Analysis of phylogenetic variation of Stenotrophomonas maltophilia reveals human-specific branches 10.3389/fmicb.2018.00806
High sequence variability of the PPE18 gene of clinical Mycobacterium tuberculosis complex strains potentially impacts effectivity of vaccine candidate M72/AS01E 10.1371/journal.pone.0152200
Emergence of Low-level Delamanid and Bedaquiline Resistance during Extremely Drug-resistant Tuberculosis Treatment 10.1093/cid/ciz074
Whole-genome sequencing for risk assessment of long-term shiga toxin-producing Escherichia coli 10.3201/eid2004.131782
Drug-resistance profiling and transmission dynamics of multidrug-resistant Mycobacterium tuberculosis in Saudi Arabia revealed by whole genome sequencing 10.2147/IDR.S181124
A Diagnostic Algorithm To Investigate Pyrazinamide and Ethambutol Resistance in Rifampin-Resistant Mycobacterium tuberculosis Isolates in a Low-Incidence Setting 10.1128/AAC.01798-18
Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: Delineation of conserved core and lineage-specific transcriptomes during intracellular survival 10.1371/journal.ppat.1000988
Risk of acquired drug resistance during short-course directly observed treatment of tuberculosis in an area will high levels of drug resistance 10.1086/517536
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis 10.1183/13993003.01354-2017
Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage 10.1038/ng.3195
Sequence analysis for detection of first-line drug resistance in Mycobacterium tuberculosis strains from a high-incidence setting 10.1186/1471-2180-12-90
Evaluation of Mycobacterium tuberculosis typing methods in a 4-year study in Schleswig-Holstein, Northern Germany 10.1128/JCM.05293-11
SeekTB, a two-stage multiplex real-time-PCR-based method for differentiation of the Mycobacterium tuberculosis complex 10.1128/JCM.00718-12
Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: A retrospective cohort study 10.1016/S1473-3099(15)00062-6
The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis 10.1016/S2213-2600(19)30263-2
Genetic Diversity of Multi-and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates in the Capital of Iran, Revealed by Whole-Genome Sequencing 10.1128/JCM.01477-18
Whole genome sequencing of Mycobacterium tuberculosis 10.1183/13993003.01163-2018
The genetic transformation of Chlamydia pneumoniae 10.1128/mSphere.00412-18
Delamanid and bedaquiline resistance in mycobacterium tuberculosis ancestral Beijing genotype causing extensively drug-resistant tuberculosis in a tibetan refugee 10.1164/rccm.201502-0372LE
PhyResSE: A web tool delineating Mycobacterium tuberculosis antibiotic resistance and lineage from whole-genome sequencing data 10.1128/JCM.00025-15
Drug-resistance mechanisms and tuberculosis drugs 10.1016/S0140-6736(14)62450-8
Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in Northwest Ethiopia: New phylogenetic lineages found in Northwest Ethiopia 10.1186/1471-2334-13-131
Integration of molecular typing results into tuberculosis surveillance in Germany - A pilot study 10.1371/journal.pone.0188356
Mycobacterium bovis isolates with M. tuberculosis specific characteristics 10.3201/eid1205.050200
Drug resistance and population structure of M.tuberculosis isolates from prisons and communities in Ethiopia 10.1186/s12879-016-2041-x
New approaches and therapeutic options for mycobacterium tuberculosis in a dormant state 10.1128/CMR.00060-17
Usefulness of the BACTEC MGIT 960 system for isolation of Mycobacterium tuberculosis from sputa subjected to long-term storage 10.1128/JCM.01985-06
Molecular clues of a microepidemy among homeless tuberculosis patients in Budapest due to a new and local Mycobacterium tuberculosis clade 10.1016/j.meegid.2007.06.003
The evolution of strain typing in the mycobacterium tuberculosis complex 10.1007/978-3-319-64371-7_3
Compensatory evolution drives multidrug-resistant tuberculosis in central Asia 10.7554/eLife.38200
New World Health Organization treatment recommendations for multidrug-resistant tuberculosis: Are we well enough prepared? 10.1164/rccm.201902-0260LE
Fast update of undetected Mycobacterium chimaera infections to reveal unsuspected cases 10.1016/j.jhin.2018.08.018
Reply to Dookie et al., “Whole-Genome Sequencing To Guide the Selection of Treatment for Drug-Resistant Tuberculosis” 10.1128/AAC.00616-18
European 1: A globally important clonal complex of Mycobacterium bovis 10.1016/j.meegid.2011.04.027
Avoiding the effect of BCG vaccination in detecting Mycobacterium tuberculosis infection with a blood test 10.1183/09031936.06.00107005
Extent of transmission captured by contact tracing in a tuberculosis high endemic setting 10.1183/13993003.01851-2016
Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes 10.1038/ng.1038
Molecular epidemiology and drug resistance patterns of mycobacterium tuberculosis complex isolates from university students and the local community in Eastern Ethiopia 10.1371/journal.pone.0198054
Comment on: Characterization of the embB gene in Mycobacterium tuberculosis isolates from Barcelona and rapid detection of main mutations related to ethambutol resistance using a low-density DNA array 10.1093/jac/dku101
Thr202Ala in thyA is a marker for the Latin American mediterranean lineage of the Mycobacterium tuberculosis complex rather than Para-aminosalicylic acid resistance 10.1128/AAC.00738-10
Integration of published information into a resistance-associated mutation database for mycobacterium tuberculosis 10.1093/infdis/jiu816
Proposal of a consensus set of hypervariable mycobacterial interspersed repetitive-unit-variable-number tandem-repeat loci for subtyping of mycobacterium tuberculosis Beijing isolates 10.1128/JCM.02519-13
Genetic diversity of Mycobacterium tuberculosis in Madang, Papua New Guinea 10.5588/ijtld.11.0779
Same meat, different gravy: Ignore the new names of mycobacteria 10.1183/13993003.00795-2019
Mycobacterium abscessus in patients with cystic fibrosis: Low impact of inter-human transmission in Italy 10.1183/13993003.02525-2016
Longitudinal outbreak of multidrug-resistant tuberculosis in a hospital setting, Serbia 10.3201/eid2503.181220
Tuberculosis recurrence and mortality after successful treatment: Impact of drug resistance 10.1371/journal.pmed.0030384
Emended description of mycobacterium abscessus mycobacterium abscessus subsp. Abscessus and mycobacterium abscessus subsp. bolletii and designation of mycobacterium abscessus subsp. massiliense comb. nov. 10.1099/ijsem.0.001376
Diversity and evolution of Mycobacterium tuberculosis: Moving to whole-genome- based approaches 10.1101/cshperspect.a021188
Variable host-pathogen compatibility in Mycobacterium tuberculosis 10.1073/pnas.0511240103
Aiming for zero tuberculosis transmission in low-burden countries 10.1016/S2213-2600(17)30382-X
Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study 10.1016/S1473-3099(17)30324-9
The relationship between transmission time and clustering methods in Mycobacterium tuberculosis epidemiology 10.1016/j.ebiom.2018.10.013
On the mutation rates of spoligotypes and variable numbers of tandem repeat loci of Mycobacterium tuberculosis 10.1016/j.meegid.2010.12.009
On the mutation rates of spoligotypes and variable numbers of tandem repeat loci of Mycobacterium tuberculosis: Continued-When tuning matters 10.1016/j.meegid.2011.03.012
Distinct genotypic profiles of the two major clades of Mycobacterium africanum 10.1186/1471-2334-10-80
Pathogen-based precision medicine for drug-resistant tuberculosis 10.1371/journal.ppat.1007297
Pulmonary tuberculosis: Virulence of Mycobacterium africanum and relevance in HIV co-infection 10.1016/j.tube.2008.05.004
Role and value of whole genome sequencing in studying tuberculosis transmission 10.1016/j.cmi.2019.03.022
Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: A TBNET/RESIST-TB consensus statement 10.5588/ijtld.15.0221
MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era. 10.1186/s13073-020-00793-8
Antimicrobial Susceptibility and Phylogenetic Relations in a German Cohort Infected with Mycobacterium abscessus. 10.1016/j.ijid.2020.02.059
In silico secretome characterization of clinical Mycobacterium abscessus isolates provides insights into antigenic differences 10.1101/2020.10.22.349720
Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical Strains. 10.1128/jcm.01304-20
Population Structure of Mycobacterium bovis in Germany: a Long-Term Study Using Whole-Genome Sequencing Combined with Conventional Molecular Typing Methods. 10.1128/jcm.01573-20
Perspective for Precision Medicine for Tuberculosis. 10.3389/fimmu.2020.566608
Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak. 10.1371/journal.ppat.1008357
Population structure, biogeography and transmissibility of Mycobacterium tuberculosis 10.1101/2020.09.29.293274
Two Pandemics, One Challenge-Leveraging Molecular Test Capacity of Tuberculosis Laboratories for Rapid COVID-19 Case-Finding. 10.3201/eid2611.202602
Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs. 10.1183/13993003.02338-2020
Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine. 10.3389/fimmu.2020.01938
Rapid genomic first- and second-line drug resistance prediction from clinical Mycobacterium tuberculosis specimens using Deeplex®-MycTB. 10.1183/13993003.01796-2020
GenomegaMap: Within-Species Genome-Wide dN/dS Estimation from over 10,000 Genomes. 10.1093/molbev/msaa069
Use of a Whole Genome Sequencing-based approach for Mycobacterium tuberculosis surveillance in Europe in 2017-2019: an ECDC pilot study. 10.1183/13993003.02272-2020
A multi-phenotype genome-wide association study of clades causing tuberculosis in a Ghanaian- and South African cohort 10.1101/2020.07.27.20162925
A publicly accessible database for Clostridioides difficile genome sequences supports tracing of transmission chains and epidemics. 10.1099/mgen.0.000410
WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by M. tuberculosis 10.1101/2020.06.26.174110
Mycobacterium tuberculosis complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to the type strain H37Rv 10.1101/2020.06.22.164186
Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history 10.1101/2020.06.10.141788
Bedaquiline-Resistant Tuberculosis: Dark Clouds on the Horizon. 10.1164/rccm.201909-1819le
Characterization of genomic variants associated with resistance to bedaquiline and delamanid in naïve Mycobacterium tuberculosis clinical strains 10.1101/2020.05.27.120451
Detection of low-frequency resistance-mediating SNPs in next-generation sequencing data of Mycobacterium tuberculosis complex strains with binoSNP. 10.1038/s41598-020-64708-8
The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia. 10.1038/s41467-020-15123-0
Library preparation for next generation sequencing: A review of automation strategies. 10.1016/j.biotechadv.2020.107537
Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex. 10.1186/s13073-020-00726-5
Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015. 10.3201/eid2603.190525
Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan1. 10.3201/eid2603.191145
A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic. 10.1186/s12916-019-1487-2
Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak 10.1101/2020.01.28.922765
Towards standardisation: comparison of five whole genome sequencing (WGS) analysis pipelines for detection of epidemiologically linked tuberculosis cases. 10.2807/1560-7917.es.2019.24.50.1900130
Accuracy of whole-genome sequencing to determine recent tuberculosis transmission: an 11-year population-based study in Hamburg, Germany. 10.1183/13993003.01154-2019
International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass. 10.1016/j.jhin.2019.10.009
Population structure of drug-resistant Mycobacterium tuberculosis in Central Asia. 10.1186/s12879-019-4480-7
Phenotypic and Transcriptomic Analyses of Seven Clinical Stenotrophomonas maltophilia Isolates Identify a Small Set of Shared and Commonly Regulated Genes Involved in the Biofilm Lifestyle. 10.1128/aem.02038-20
The relationship between transmission time and clustering methods inMycobacterium tuberculosisepidemiology 10.1101/302232
EUSeqMyTB to set standards and build capacity for whole genome sequencing for tuberculosis in the EU. 10.1016/s1473-3099(18)30132-4
A novel multi SNP based method for the identification of subspecies and associated lineages and sub-lineages of theMycobacterium tuberculosiscomplex by whole genome sequencing 10.1101/213850
Comparative genomics ofMycobacterium africanumLineage 5 and Lineage 6 from Ghana suggests different ecological niches 10.1101/202234
Mycobacterium bovis Persistence in Two Different Captive Wild Animal Populations in Germany: a Longitudinal Molecular Epidemiological Study Revealing Pathogen Transmission by Whole-Genome Sequencing. 10.1128/jcm.00302-18
Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis. 10.1128/aac.00344-18
Reference Set ofMycobacterium tuberculosisClinical Strains: A tool for research and product development 10.1101/399709
Smear Microscopy for Diagnosis of Pulmonary Tuberculosis in Eastern Sudan. 10.1155/2018/8038137
Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia 10.1101/334599
Molecular epidemiology and drug resistance patterns ofMycobacterium tuberculosiscomplex isolates from university students and the local community in Eastern Ethiopia 10.1101/322958
The global phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia 10.1101/748954
DeepAMR for predicting co-occurrent resistance of Mycobacterium tuberculosis. 10.1093/bioinformatics/btz067
Global genomic population structure of Clostridioides difficile 10.1101/727230
Isoniazid resistance in Mycobacterium tuberculosis is a heterogeneous phenotype comprised of overlapping MIC distributions with different underlying resistance mechanisms 10.1101/524157
Systematic rifampicin resistance errors with Xpert® MTB/RIF Ultra: implications for regulation of genotypic assays. 10.5588/ijtld.20.0396
Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe. 10.12688/wellcomeopenres.15603.1
Molecular surveillance of multi- and extensively drug-resistant tuberculosis transmission in the European Union from 2003 to 2011. 10.2807/1560-7917.es2014.19.11.20742
Common patterns and disease-related signatures in tuberculosis and sarcoidosis. 10.1073/pnas.1121072109
Use of the genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis complex isolates. 10.1128/jcm.43.8.3699-3703.2005
A Pyrosequencing assay for rapid recognition of SNPs in Mycobacterium tuberculosis embB306 region. 10.1016/j.mimet.2005.02.004
Identification and characterization of genomic variations between Mycobacterium bovis and M. tuberculosis H37Rv. 10.1128/jcm.43.5.2481-2484.2005
Occupational risk of tuberculosis transmission in a low incidence area. 10.1186/1465-9921-6-35
Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany. 10.1128/aac.49.3.1229-1231.2005
Conventional and molecular epidemiology of tuberculosis in homeless patients in Budapest, Hungary. 10.1128/jcm.42.12.5931-5934.2004
Definition of the Beijing/W lineage of Mycobacterium tuberculosis on the basis of genetic markers. 10.1128/jcm.42.9.4040-4049.2004
The species Mycobacterium africanum in the light of new molecular markers. 10.1128/jcm.42.9.3958-3962.2004
Genomic analysis distinguishes Mycobacterium africanum. 10.1128/jcm.42.8.3594-3599.2004
Molecular epidemiology of tuberculosis among immigrants in Hamburg, Germany. 10.1128/jcm.42.7.2952-2960.2004
Molecular characterization of rifampin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Poland. 10.1128/jcm.42.6.2425-2431.2004
Prospective molecular epidemiological study on transmission of pulmonary Tuberculosis and Migration (MuT study) -- an interim report. 10.1055/s-0038-1633901
[Spread of a drug-resistant strain of mycobacterium tuberculosis among homeless people in a German city] 10.1055/s-2003-812442
Simultaneous detection and differentiation of Theileria and Babesia parasites infecting small ruminants by reverse line blotting. 10.1007/s00436-003-0980-9
RIDOM: comprehensive and public sequence database for identification of Mycobacterium species. 10.1186/1471-2334-3-26
Pulmonary tuberculosis due to Mycobacterium bovis subsp. caprae in captive Siberian tiger. 10.3201/eid0911.030297
Phylogeny of sheep and goat Theileria and Babesia parasites. 10.1007/s00436-003-0979-2
Molecular epidemiology of pulmonary tuberculosis in belgrade, central serbia. 10.1128/jcm.41.9.4372-4377.2003
Mycobacterium bovis subsp. caprae caused one-third of human M. bovis-associated tuberculosis cases reported in Germany between 1999 and 2001. 10.1128/jcm.41.7.3070-3077.2003
Evaluation of genotype MTBC assay for differentiation of clinical Mycobacterium tuberculosis complex isolates. 10.1128/jcm.41.6.2672-2675.2003
Mycobacterium holsaticum sp. nov. 10.1099/00207713-52-6-1991
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. 10.1128/iai.70.10.5568-5578.2002
Mycobacterium africanum subtype II is associated with two distinct genotypes and is a major cause of human tuberculosis in Kampala, Uganda. 10.1128/jcm.40.9.3398-3405.2002
Biochemical and genetic evidence for the transfer of Mycobacterium tuberculosis subsp. caprae Aranaz et al. 1999 to the species Mycobacterium bovis Karlson and Lessel 1970 (approved lists 1980) as Mycobacterium bovis subsp. caprae comb. nov. 10.1099/00207713-52-2-433
Epidemiology of tuberculosis in Hamburg, Germany: long-term population-based analysis applying classical and molecular epidemiological techniques. 10.1128/jcm.40.2.532-539.2002
Description of Mycobacterium heckeshornense sp. nov. 10.1128/jcm.39.8.3023-3024.2001
Mycobacterium microti llama-type infection presenting as pulmonary tuberculosis in a human immunodeficiency virus-positive patient. 10.1128/jcm.39.1.406-407.2001
Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates. 10.1128/jcm.39.1.107-110.2001
Double infection with a resistant and a multidrug-resistant strain of Mycobacterium tuberculosis. 10.3201/eid0605.000518
Two cases of Mycobacterium microti derived tuberculosis in HIV-negative immunocompetent patients. 10.3201/eid0605.000516
Differentiation of clinical Mycobacterium tuberculosis complex isolates by gyrB DNA sequence polymorphism analysis. 10.1128/jcm.38.9.3231-3234.2000
Detection, identification, and treatment of a novel, non-cultivable Mycobacterium species in an HIV patient. 10.1097/00002030-200007280-00028
Stability of IS6110 restriction fragment length polymorphism patterns of Mycobacterium tuberculosis strains in actual chains of transmission. 10.1128/jcm.38.7.2563-2567.2000
Genetic basis of enterobacterial repetitive intergenic consensus (ERIC)-PCR fingerprint pattern in Sinorhizobium meliloti and identification of S. meliloti employing PCR primers derived from an ERIC-PCR fragment. 10.1007/s002030050735
Identification of Mycobacterium kansasii by using a DNA probe (AccuProbe) and molecular techniques. 10.1128/jcm.37.4.964-970.1999
Stability of Mycobacterium tuberculosis IS6110 restriction fragment length polymorphism patterns and spoligotypes determined by analyzing serial isolates from patients with drug-resistant tuberculosis. 10.1128/jcm.37.2.409-412.1999
IS6110 fingerprinting of drug-resistant Mycobacterium tuberculosis strains isolated in Germany during 1995. 10.1128/jcm.35.12.3015-3020.1997
Evaluation of the resolving power of three different DNA fingerprinting methods to discriminate among isolates of a natural Rhizobium meliloti population. 10.1046/j.1365-2672.1997.00141.x
Biocontrol strain Pseudomonas fluorescens CHA0 and its genetically modified derivative with enhanced biocontrol capability exert comparable effects on the structure of a Sinorhizobium meliloti population in gnotobiotic systems. 10.1007/s003740050309
Characterization of two bioluminescent Rhizobium meliloti strains constructed for field releases. 10.1007/bf00578463
A biological containment system for Rhizobium meliloti based on the use of recombination-deficient (recA-) strains. 10.1016/0168-6496(94)00086-c
Roland Brosch
Brosch Roland
ORCID: 0000-0003-2587-3863
Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity. 10.1016/j.chom.2015.05.017
Insights on the emergence of Mycobacterium tuberculosis from the analysis of Mycobacterium kansasii 10.1093/gbe/evv035
Mycobacterial Pathogenomics and Evolution. 10.1128/microbiolspec.MGM2-0025-2013
Release of mycobacterial antigens 10.1111/imr.12251
Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice 10.1128/IAI.02032-14
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083
Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations 10.1038/srep15443
ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection 10.1016/j.tube.2015.02.019
Developing whole mycobacteria cell vaccines for tuberculosis: Workshop proceedings, Max Planck Institute for Infection Biology, Berlin, Germany, July 9, 2014 10.1016/j.vaccine.2015.03.056
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650
Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans | Les bacilles de la tuberculose bovine - Une évolution aux dépens de la transmissibilité chez l'homme 10.1051/medsci/20153102003
Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection 10.1371/journal.ppat.1003928
Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development 10.2217/fmb.14.70
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator 10.1073/pnas.1406693111
Bacillus calmette-guérin strain differences have an impact on clinical outcome in bladder cancer immunotherapy 10.1016/j.eururo.2014.02.061
A Specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies whiB6 as a novel ESX-1 component 10.1128/IAI.01824-14
A glimpse into the past and predictions for the future: The molecular evolution of the tuberculosis agent 10.1111/mmi.12720
TBCAP; Tuberculosis annotation project 10.1016/j.tube.2012.11.013
Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus 10.1111/mmi.12387
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis 10.1038/ng.2517
ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis 10.1111/cmi.12169
Characterization of Mycobacterium orygis 10.3201/eid1903.121005
The ESX-5 Associated eccB5-eccC5 Locus Is Essential for Mycobacterium tuberculosis Viability 10.1371/journal.pone.0052059
Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion-encoded PE-PPE proteins predicts vaccine potential 10.1016/j.chom.2012.03.003
Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death 10.1371/journal.ppat.1002507
Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh 10.1371/journal.pone.0040545
Molecular epidemiology of tuberculosis in rural Matlab, Bangladesh 10.5588/ijtld.11.0426
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria 10.1111/j.1462-5822.2012.01799.x
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells 10.4161/auto.20881
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation 10.1111/j.1365-2958.2012.08001.x
Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies 10.3201/eid1804.110888
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis 10.1002/eji.201141548
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways 10.1074/jbc.M111.223610
Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants 10.1111/j.1462-5822.2010.01565.x
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG 1on virulence of Mycobacterium tuberculosis 10.1093/infdis/jiq089
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237 10.1016/j.tube.2010.12.007
Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring 10.1016/j.ejmech.2010.09.048
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling 10.1371/journal.ppat.1001100
Entrapment of intracytosolic bacteria by septin cage-like structures 10.1016/j.chom.2010.10.009
Systematic genetic nomenclature for type VII secretion systems 10.1371/journal.ppat.1000507
Pathogenomics of mycobacteria 10.1159/000235772
Pathogenicity in the tubercle bacillus: Molecular and evolutionary determinants 10.1002/bies.200800191
Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus 10.1371/journal.pone.0005660
Myths and misconceptions: The origin and evolution of Mycobacterium tuberculosis 10.1038/nrmicro2165
Mycobacterial PE, PPE and ESX clusters: Novel insights into the secretion of these most unusual protein families 10.1111/j.1365-2958.2009.06784.x
High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors 10.1371/journal.ppat.1000645
ESX/type VII secretion systems and their role in host-pathogen interaction 10.1016/j.mib.2008.11.003
Benzothiazinones Kill Mycobacterium tuberculosis by blocking Arabinan synthesis 10.1126/science.1171583
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis 10.1101/gr.075069.107
Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism 10.1099/mic.0.2008/022269-0
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033
BCG: Molecular history and new perspectives | Le BCG: Histoire moléculaire et nouvelles perspectives RMR-06-2008-25-00-01761-8425-101019-200806495
Genome plasticity of BCG and impact on vaccine efficacy 10.1073/pnas.0700869104
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 10.1128/JB.00469-07
Pathogenomics: Insights into Tuberculosis and Related Mycobacterial Diseases 10.1002/352760801X.ch10
Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis 10.1093/molbev/msj120
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/IAI.74.1.88-98.2006
Contribution of mycobacterial genomics to the development of innovative strategies against tuberculosis | Apports de la génomique des mycobactéries a la définition de nouvelles stratégies thérapeutiques et vaccinales anti-tuberculeuses 10.1016/S1773-035X(06)80148-6
"A re-evaluation of M. prototuberculosis": Continuing the debate 10.1371/journal.ppat.0020095
Tuberculosis: From genome to vaccine 10.1586/14760584.4.4.541
Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against Oxidative Stress 10.1074/jbc.M503076200
Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: The contribution of endogenous mycolactone toxin 10.1111/j.1462-5822.2005.00546.x
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200
Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans 10.1128/JB.187.5.1668-1676.2005
Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis 10.1371/journal.ppat.0010005
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans 10.1073/pnas.0305877101
Genotypic Analysis of Mycobacterium tuberculosis in Bangladesh and Prevalence of the Beijing Strain 10.1128/JCM.42.2.674-682.2004
ESAT-6 proteins: Protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468
Cell Envelope Protein PPE68 Contributes to Mycobacterium tuberculosis RD1 Immunogenicity Independently of A 10-Kilodalton Culture Filtrate Protein and ESAT-6 10.1128/IAI.72.4.2170-2176.2004
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/nm859
Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex? [3] (multiple letters) 10.1128/JCM.41.3.1345-1348.2003
Royal society of tropical medicine and hygiene meeting at Manson house, London, 18 January 2001: Pathogen genomes and human health. Mycobacterial genomics 10.1016/S0035-9203(02)90222-1
Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysis 10.1128/JCM.40.7.2339-2345.2002
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant 10.1128/IAI.70.10.5568-5578.2002
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
The evolution of mycobacterial pathogenicity: Clues from comparative genomics 10.1016/S0966-842X(01)02131-X
Genomics of Mycobacterium bovis 10.1054/tube.2000.0269
Tools for the population genomics of the tubercle bacilli 10.1101/gr.169200
Comparative genomics of the leprosy and tubercle bacilli 10.1016/S0923-2508(00)00117-0
Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays 10.1046/j.1365-2958.1999.01383.x
Analysis of the proteome of Mycobacterium tuberculosis in silico 10.1054/tuld.1999.0220
The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes 10.1046/j.1365-2958.1998.01124.x
Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence 10.1038/31159
Genomic fingerprinting of 80 strains from the WHO multicenter international typing study of Listeria monocytogenes via pulsed-field gel electrophoresis (PFGE) 10.1016/S0168-1605(96)01147-6
Characterization of Listeria strains isolated from soft cheese 10.1016/0168-1605(93)90220-B
Listeriosis outbreak in France in 1992. Microbial data | Epidémie de listériose en France en 1992 aspects microbiologiques 10.1016/S0399-077X(05)81214-4
Use of pulsed field gel electrophoresis to compare large DNA-restriction fragments of Listeria monocytogenes strains belonging to serogroups 1/2 and 3 10.1016/0168-1605(91)90121-5
Subtyping of Listeria monocytogenes serovar 4b by use of low-frequency-cleavage restriction endonucleases and pulsed-field gel electrophoresis 10.1016/0923-2508(91)90080-T
Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions 10.1038/srep17078
Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis 10.1038/srep16918
Drug-resistant tuberculosis in the European Union: opportunities and challenges for control. 10.1016/j.tube.2010.03.008
The BCG Strain Pool: Diversity Matters. 10.1038/mt.2016.18
Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications. 10.1186/s12864-016-2448-1
Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access. 10.1111/cmi.12622
Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria 10.1073/pnas.1604921113
Comparative Genomics and Evolution of Mycobacterium bovis BCG 10.1128/9781555817657.ch10
The Mycobacteria: a Postgenomic View 10.1128/9781555815530.ch3
Genomics ofMycobacterium Tuberculosis and Mycobacterium Leprae 10.1002/9781444311433.ch5
Genomics of the Mycobacterium tuberculosis complex and Mycobacterium leprae 10.1002/047001153x.g205204
ESX secretion systems: mycobacterial evolution to counter host immunity 10.1038/nrmicro.2016.131
Resistance to thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384 10.1128/aac.02509-16
ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis. 10.1111/cmi.12726
Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis 10.1038/mi.2016.140
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection 10.1016/j.celrep.2017.02.057
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis 10.1371/journal.ppat.1006399
Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells 10.1038/s41598-017-05878-w
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101
Evolution of virulence in the Mycobacterium tuberculosis complex 10.1016/j.mib.2017.11.021
The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis 10.3389/fmicb.2017.02284
Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis 10.1038/s41564-017-0090-6
Discovery of the type VII ESX-1 secretion needle? 10.1111/mmi.13579
Identification of genes required forMycobacterium abscessusgrowth in vivo with a prominent role of the ESX-4 locus 10.1073/pnas.1713195115
Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions 10.1073/pnas.1620133114
Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation 10.1371/journal.ppat.1006752
The Biology and Epidemiology of Mycobacterium canettii 10.1007/978-3-319-64371-7_2
Targeting Type VII/ESX Secretion Systems for Development of Novel Antimycobacterial Drugs 10.2174/1381612819666131118170717
Taxonomic Diversity of Pseudomonads Revealed by Computer-interpretation of Ribotyping Data 10.1016/s0723-2020(96)80026-9
Comparative genomics of the mycobacteria 10.1016/s1438-4221(00)80083-1
Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens 10.3791/50116
Type VII Secretion Systems in Gram-Positive Bacteria 10.1007/82_2015_5015
Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: ‘Aethiops vetus’ 10.1099/mgen.0.000063
Leprosy in red squirrels 10.1126/science.aal0145
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection 10.1371/journal.ppat.1005770
pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence 10.1038/nmicrobiol.2015.19
A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence ofMycobacterium marinumin multiple hosts 10.1111/cmi.12606
The PE and PPE Protein Families of Mycobacterium tuberculosis 10.1002/9783527611614.ch7
Influence of ESAT-6 Secretion System 1 (RD1) of Mycobacterium tuberculosis on the Interaction between Mycobacteria and the Host Immune System 10.4049/jimmunol.174.6.3570
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125
ESAT-6–dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo 10.1172/jci84978
Cutting-edge science and the future of tuberculosis control 10.2471/blt.06.035386
ESAT-6 and the Mycobacterial ESX Secretion Systems 10.1128/9781555815783.ch13
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection 10.1371/journal.ppat.1007139
Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity 10.1093/gbe/evy145
New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach 10.1016/j.jprot.2018.09.013
Update on the virulence factors of the obligate pathogen Mycobacterium tuberculosis and related tuberculosis-causing mycobacteria 10.1016/j.meegid.2018.12.013
Shared Pathogenomic Patterns Characterize a New Phylotype, Revealing Transition toward Host-Adaptation Long before Speciation of Mycobacterium tuberculosis 10.1093/gbe/evz162
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis. 10.1021/acsnano.8b07902
Mycobacterial virulence: impact on immunogenicity and vaccine research 10.12688/f1000research.20572.1
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages 10.1038/s41467-020-14508-5
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis 10.1038/s41598-020-58967-8
ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins 10.1128/microbiolspec.psib-0029-2019
ESX-4, un système de sécrétion mycobactérien ancestral, essentiel pour la croissance de Mycobacterium abscessus dans les phagocytes environnementaux et humains 10.1051/medsci/2018196
Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages 10.1371/journal.ppat.1008069
A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies 10.1126/sciadv.aaz1767
Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential 10.1016/j.ebiom.2020.102761
Mucosal delivery of ESX-1–expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes 10.1073/pnas.2003235117
Le BCG : histoire moléculaire et nouvelles perspectives 10.1016/s0761-8425(08)56032-3
Breaching the phagosome, the case of the tuberculosis agent 10.1111/cmi.13344
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection 10.7554/elife.55692
IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo 10.1128/mSphere.00153-21
ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains 10.1128/mBio.00965-21
Evolution of Mycobacterium tuberculosis : New Insights into Pathogenicity and Drug Resistance 10.1128/microbiolspec.tbtb2-0020-2016
Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors 10.3389/fcimb.2020.00420
Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli 10.1038/s41564-021-00938-4
Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran