Paperbase

Convergent evolution of pain-inducing defensive venom components in spitting cobras

Kazandjian, T.D. Petras, D. Robinson, S.D. van Thiel, J. Greene, H.W. Arbuckle, K. Barlow, A. Carter, D.A. Wouters, R.M. Whiteley, G. Wagstaff, S.C. Arias, A.S. Albulescu, L.-O. Plettenberg Laing, A. Hall, C. Heap, A. Penrhyn-Lowe, S. McCabe, C.V. Ainsworth, S. da Silva, R.R. Dorrestein, P.C. Richardson, M.K. Gutiérrez, J.M. Calvete, J.J. Harrison, R.A. Vetter, I. Undheim, E.A.B. Wüster, W. Casewell, N.R.

Science (New York, N.Y.), 2021

https://doi.org/10.1126/science.abb9303

Juan Calvete

Calvete Juan / Juanjo Calvete

ORCID: 0000-0001-5026-3122

http://scholar.google.com/citations?user=3J6y5bkAAAAJ&hl=en

http://www.journals.elsevier.com/journal-of-proteomics

http://www.ncbi.nlm.nih.gov/pubmed/?term=Calvete+JJ

http://www.proteomicsresearch.org/labs.php

http://www.researchgate.net/profile/Juan_Calvete2?ev=hdr_xprf

http://www3.ibv.csic.es/index.php/es/investigacion/genomica/upr

Next-generation snake venomics: Protein-locus resolution through venom proteome decomplexation 10.1586/14789450.2014.900447

Understanding structural and functional aspects of PII snake venom metalloproteinases: Characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis 10.1016/j.biochi.2014.01.008

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms 10.1073/pnas.1405484111

Two color morphs of the pelagic yellow-bellied sea snake, Pelamis platura, from different locations of Costa Rica: Snake venomics, toxicity, and neutralization by antivenom 10.1016/j.jprot.2014.03.034

Characterization and cDNA sequence of Bothriechis schlegeliil-amino acid oxidase with antibacterial activity. 10.1016/j.ijbiomac.2014.05.039

Inhibitory effects of recombinant RTS-jerdostatin on integrin α1β1 function during adhesion, migration and proliferation of rat aortic smooth muscle cells and angiogenesis 10.1016/j.toxicon.2013.12.006

Venomous snakes of Costa Rica: Biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics 10.1016/j.jprot.2014.02.020

Immunological profile of antivenoms: Preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays 10.1016/j.jprot.2014.02.021

Putting value in biomarker research and reporting 10.1016/j.jprot.2013.12.002

Venomics of new world pit vipers: Genus-wide comparisons of venom proteomes across agkistrodon 10.1016/j.jprot.2013.10.036

The expanding universe of mass analyzer configurations for biological analysis 10.1007/978-1-62703-631-3_6

Snake venomics: From the inventory of toxins to biology 10.1016/j.toxicon.2013.03.020

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system 10.1073/pnas.1314702110

Amino acid sequence and biological characterization of BlatPLA₂, a non-toxic acidic phospholipase A₂ from the venom of the arboreal snake Bothriechis lateralis from Costa Rica. 10.1016/j.toxicon.2013.07.008

Cytotoxic activities of [Ser⁴⁹]phospholipase A₂ from the venom of the saw-scaled vipers Echis ocellatus, Echis pyramidum leakeyi, Echis carinatus sochureki, and Echis coloratus. 10.1016/j.toxicon.2013.05.017

Protein profile of Lupinus texensis phloem sap exudates: Searching for Fe- and Zn-containing proteins 10.1002/pmic.201200515

Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis 10.1016/j.jprot.2013.05.028

Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics 10.1016/j.toxicon.2012.11.016

Identification of inhibitors of α2β1 integrin, members of C-lectin type proteins, in Echis sochureki venom 10.1016/j.taap.2013.03.002

Cloning and characterization of an antibacterial l-amino acid oxidase from Crotalus durissus cumanensis venom 10.1016/j.toxicon.2012.11.027

Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays 10.1016/j.toxicon.2012.12.024

The continuing saga of snake venom disintegrins 10.1016/j.toxicon.2012.09.005

PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells 10.1016/j.matbio.2012.11.015

The Need for Full Integration of Snakebite Envenoming within a Global Strategy to Combat the Neglected Tropical Diseases: The Way Forward 10.1371/journal.pntd.0002162

Phylogeny-Based Comparative Analysis of Venom Proteome Variation in a Clade of Rattlesnakes (Sistrurus sp.) 10.1371/journal.pone.0067220

Integrated "omics" profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus 10.1186/1471-2164-14-234

Updating JPROT's publication standards for large-scale proteomic studies: Towards hypothesis-driven interpretation of predictive biological models 10.1016/j.jprot.2012.08.022

Snake venomics across genus Lachesis. Ontogenetic changes in the venom composition of Lachesis stenophrys and comparative proteomics of the venoms of adult Lachesis melanocephala and Lachesis acrochorda 10.1016/j.jprot.2012.09.003

Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses 10.1016/j.jprot.2012.08.008

First draft of the genomic organization of a PIII-SVMP gene 10.1016/j.toxicon.2012.04.331

Venomics, what else? 10.1016/j.toxicon.2012.05.012

Recombinant expression of mutants of the Frankenstein disintegrin, RTS-ocellatusin. Evidence for the independent origin of RGD and KTS/RTS disintegrins 10.1016/j.toxicon.2012.05.010

Second generation snake antivenomics: Comparing immunoaffinity and immunodepletion protocols 10.1016/j.toxicon.2012.04.342

Snake venomics of two poorly known Hydrophiinae: Comparative proteomics of the venoms of terrestrial Toxicocalamus longissimus and marine Hydrophis cyanocinctus 10.1016/j.jprot.2012.05.026

Identification of new snake venom metalloproteinase inhibitors using compound screening and rational peptide design 10.1021/ml300068r

Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from Southern Arizona 10.1016/j.jprot.2012.02.035

Combined snake venomics and venom gland transcriptomic analysis of Bothropoides pauloensis 10.1016/j.jprot.2012.03.028

Snake venomics of Macrovipera mauritanica from Morocco, and assessment of the para-specific immunoreactivity of an experimental monospecific and a commercial antivenoms 10.1016/j.jprot.2012.02.022

Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity 10.1016/j.jprot.2012.01.006

Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica 10.1016/j.toxicon.2012.01.005

Venomics and antivenomics profiles of North African Cerastes cerastes and C. vipera populations reveals a potentially important therapeutic weakness 10.1016/j.jprot.2012.02.021

Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: Toxicological and taxonomical insights 10.1016/j.jprot.2011.12.016

Snake venomics of Crotalus tigris: The minimalist toxin arsenal of the deadliest neartic rattlesnake venom. Evolutionary clues for generating a pan-specific antivenom against crotalid type II venoms 10.1021/pr201021d

Resurrexit, sicut dixit, alleluia. Snake venomics from a 26-year old polyacrylamide focusing gel 10.1016/j.jprot.2011.09.021

Unusual stability of messenger RNA in snake venom reveals gene expression dynamics of venom replenishment 10.1371/journal.pone.0041888

Proteomic tools against the neglected pathology of snake bite envenoming 10.1586/epr.11.61

Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom 10.1016/j.toxicon.2011.08.018

JPROT=∑3Y>1017m5.074IF2Tu. 10.1016/j.jprot.2011.06.030

Proteomic analysis of ontogenetic and diet-related changes in venom composition of juvenile and adult Dusky Pigmy rattlesnakes (Sistrurus miliarius barbouri) 10.1016/j.jprot.2011.06.013

Omic technologies to fight the neglect 10.1016/j.jprot.2011.07.004

NMR structure and dynamics of recombinant wild type and mutated jerdostatin, a selective inhibitor of integrin α1β1. 10.1002/prot.23076

Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa 10.1016/j.jprot.2011.05.027

Snake venomics and venom gland transcriptomic analysis of Brazilian coral snakes, Micrurus altirostris and M. corallinus 10.1016/j.jprot.2011.04.003

Seminal plasma proteins: what role do they play? 10.1111/j.1600-0897.2011.01033.x

Quality of boar spermatozoa from the sperm-peak portion of the ejaculate after simplified freezing in MiniFlatpacks compared to the remaining spermatozoa of the sperm-rich fraction 10.1016/j.theriogenology.2010.11.024

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management 10.1016/j.jprot.2011.01.003

Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae) 10.1021/pr101091a

Snake venomics of African spitting cobras: Toxin composition and assessment of congeneric cross-reactivity of the Pan-African EchiTAb-Plus-ICP antivenom by antivenomics and neutralization approaches 10.1021/pr101040f

Protein Composition of Seminal Plasma in Fractionated Stallion Ejaculates 10.1111/j.1439-0531.2010.01641.x

Crystal structure of the zinc-, cobalt-, and iron-containing adenylate kinase from Desulfovibrio gigas: A novel metal-containing adenylate kinase from Gram-negative bacteria 10.1007/s00775-010-0700-8

Profiling the venom gland transcriptomes of costa rican snakes by 454 pyrosequencing 10.1186/1471-2164-12-259

Antivenomics and venom phenotyping: A marriage of convenience to address the performance and range of clinical use of antivenoms 10.1016/j.toxicon.2009.12.015

Recombinant expression in human cells of active integrin alpha 1 beta 1-blocking RTS-disintegrin jerdostatin. 10.1016/j.toxicon.2010.07.013

Isolation and biological characterization of Batx-I, a weak hemorrhagic and fibrinogenolytic PI metalloproteinase from Colombian Bothrops atrox venom 10.1016/j.toxicon.2010.06.016

Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: Assessment of geographic variation and its implication on snakebite management 10.1016/j.jprot.2010.06.001

Snake venomics of bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: Different evolutionary solutions for the same trophic purpose 10.1021/pr100545d

Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa 10.4269/ajtmh.2010.09-0733

Exploring the venom proteome of the African puff adder, Bitis arietans, using a combinatorial peptide ligand library approach at different pHs 10.1016/j.jprot.2009.12.006

Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization. 10.1016/j.biochi.2009.12.006

Crystal structure and statistical coupling analysis of highly glycosylated peroxidase from royal palm tree (Roystonea regia) 10.1016/j.jsb.2009.10.009

Spermadhesin PSP-I/PSP-II heterodimer induces migration of polymorphonuclear neutrophils into the uterine cavity of the sow 10.1016/j.jri.2009.10.007

Impact of regional variation in Bothrops asper snake venom on the design of antivenoms: Integrating antivenomics and neutralization approaches 10.1021/pr9009518

Snake venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America 10.1021/pr9008749

Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa. 10.1016/j.toxicon.2009.08.010

Studies on the venom proteome of Bothrops asper: Perspectives and applications 10.1016/j.toxicon.2009.06.011

Proteomic analysis of phosphorylated nuclear proteins underscores novel roles for rapid actions of retinoic acid in the regulation of mRNA splicing and translation 10.1210/me.2009-0165

Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism 10.1016/j.jprot.2009.07.013

PSP-I/PSP-II spermadhesin exert a decapacitation effect on highly extended boar spermatozoa 10.1111/j.1365-2605.2008.00887.x

Isolation and characterization of a new Cu-Fe protein from Desulfovibrio aminophilus DSM12254 10.1016/j.jinorgbio.2009.04.014

Effect of VP12 and viperistatin on inhibition of collagen-receptor-dependent melanoma metastasis. 10.4161/cbt.8.15.8999

Mitochondrial and nuclear localization of a novel pea thioredoxin: identification of its mitochondrial target proteins. 10.1104/pp.109.138073

Exploring the venom proteome of the western diamondback rattlesnake, Crotalus atrox, via snake venomics and combinatorial peptide ligand library approaches 10.1021/pr900249q

Venoms, venomics, antivenomics 10.1016/j.febslet.2009.03.029

Distinct effects of boar seminal plasma fractions exhibiting different protein profiles on the functionality of highly diluted boar spermatozoa 10.1111/j.1439-0531.2007.01028.x

Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management 10.1016/j.jprot.2009.01.005

Venomics: Digging into the evolution of venomous systems and learning to twist nature to fight pathology 10.1016/j.jprot.2009.01.018

Exposure to the seminal plasma of different portions of the boar ejaculate modulates the survival of spermatozoa cryopreserved in MiniFlatPacks 10.1016/j.theriogenology.2008.09.037

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming 10.1016/j.jprot.2009.01.008

Snake population venomics: Proteomics-based analyses of individual variation reveals significant gene regulation effects on venom protein expression in sistrurus rattlesnakes 10.1007/s00239-008-9186-1

Structural requirements of KTS-disintegrins for inhibition of alpha(1)beta(1) integrin. 10.1042/BJ20081403

Analysis of chronic lymphotic leukemia transcriptomic profile: Differences between molecular subgroups 10.1080/10428190802541807

Combined snake venomics and venom gland transcriptomic analysis of the ocellated carpet viper, Echis ocellatus 10.1016/j.jprot.2008.10.003

Major proteins of boar seminal plasma as a tool for biotechnological preservation of spermatozoa 10.1016/j.theriogenology.2008.07.013

Evolution of snake venom disintegrins by positive Darwinian selection 10.1093/molbev/msn179

Snake venomics of the Brazilian pitvipers Bothrops cotiara and Bothrops fonsecai. Identification of taxonomy markers 10.1016/j.jprot.2008.07.007

Snake venomics of the lesser antillean pit vipers bothrops caribbaeus and Bothrops lanceolatus: Correlation with toxicological activities and immunoreactivity of a heterologous antivenom 10.1021/pr8003826

Localization and expression of spermadhesin PSP-I/PSP-II subunits in the reproductive organs of the boar 10.1111/j.1365-2605.2007.00784.x

Snake venomics of the lancehead pitviper bothrops asper. Geographic, individual, and ontogenetic variations 10.1021/pr800332p

Snake venomics of the Armenian mountain vipers Macrovipera lebetina obtusa and Vipera raddei 10.1016/j.jprot.2008.05.003

Snake venomics and antivenomics of the arboreal neotropical pitvipers bothriechis lateralis and bothriechis schlegelii 10.1021/pr8000139

Point mutations abolishing the mannose-binding capability of boar spermadhesin AQN-1 10.1016/j.bbapap.2008.02.015

Journal of Proteomics - An evolving star in the expanding proteomics galaxy 10.1016/j.jprot.2008.03.003

Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis 10.1016/j.jprot.2007.10.004

Meeting report MPSA 2007 10.1016/j.jprot.2008.03.001

Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins 10.1128/JB.01349-07

Mucin-type O-glycosylation in Mesocestoides vogae (syn. corti) 10.1016/j.ijpara.2007.07.015

Snake venomics of Central American pitvipers: Clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi 10.1021/pr700610z

Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper. 10.1590/S0100-879X2006005000189

Insights into the structural basis of the pH-dependent dimer-tetramer equilibrium through crystallographic analysis of recombinant Diocleinae lectins 10.1042/BJ20070942

Analysis of O-glycosylation. 10.1007/978-1-60327-084-7_20

Acid-base disarrangement and gastric intramucosal acidosis predict outcome from major trauma. 10.1590/S0104-42302008000200012

Thermodynamic characterization of the palm tree Roystonea regia peroxidase stability 10.1016/j.biochi.2008.07.010

A new type of metal-binding site in cobalt- and zinc-containing adenylate kinases isolated from sulfate-reducers Desulfovibrio gigas and Desulfovibrio desulfuricans ATCC 27774 10.1016/j.jinorgbio.2008.01.023

Isolation and characterization of the main small heat shock proteins induced in tomato pericarp by thermal treatment 10.1111/j.1742-4658.2007.06162.x

Complement regulation in murine and human hypercholesterolemia and role in the control of macrophage and smooth muscle cell proliferation 10.1016/j.cardiores.2007.06.028

Snake venomics. Strategy and applications 10.1002/jms.1242

Improving the fertilizing ability of sex sorted boar spermatozoa 10.1016/j.theriogenology.2007.06.006

Snake venomics of Bitis species reveals large intragenus venom toxin composition variation: Application to taxonomy of congeneric taxa 10.1021/pr0701714

Proteomic identification of actin-derived oligopeptides in dry-cured ham 10.1021/jf061911g

VEGF-related protein isolated from Vipera palestinae venom, promotes angiogenesis 10.1080/08977190701532385

Crystal structures of Cratylia floribunda seed lectin at acidic and basic pHs. Insights into the structural basis of the pH-dependent dimer-tetramer transition 10.1016/j.jsb.2006.08.014

Proteomic Profiling of a Snake Venom Using High Mass Detection MALDI-TOF Mass Spectrometry 10.1016/j.jasms.2006.11.007

Loss of introns along the evolutionary diversification pathway of snake venom disintegrins evidenced by sequence analysis of genomic DNA from Macrovipera lebetina transmediterranea and Echis ocellatus 10.1007/s00239-006-0161-4

Snake venomics of Bitis gabonica gabonica. Protein family composition, subunit organization of venom toxins, and characterization of dimeric disintegrins bitisgabonin-1 and bitisgabonin-2 10.1021/pr060494k

KTS and RTS-disintegrins: anti-angiogenic viper venom peptides specifically targeting the alpha 1 beta 1 integrin. 10.2174/138161207782023766

Cryosurvival and in vitro fertilizing capacity postthaw is improved when boar spermatozoa are frozen in the presence of seminal plasma from good freezer boars 10.2164/jandrol.107.002725

Venom proteomes of closely related Sistrurus rattlesnakes with divergent diets 10.1021/pr0602500

cDNA cloning and 1.75 Å crystal structure determination of PPL2, an endochitinase and N-acetylglucosamine-binding hemagglutinin from Parkia platycephala seeds 10.1111/j.1742-4658.2006.05400.x

Molecular cloning of Echis ocellatus disintegrins reveals non-venom-secreted proteins and a pathway for the evolution of ocellatusin 10.1007/s00239-005-0269-y

Characterizing the tick carboxypeptidase inhibitor: Molecular basis for its two-domain nature 10.1074/jbc.M602301200

Molecular cloning of disintegrin-like transcript BA-5A from a Bitis arietans venom gland cDNA library: A putative intermediate in the evolution of the long-chain disintegrin bitistatin 10.1007/s00239-005-0268-z

Zinc ions induce the unfolding and self-association of boar spermadhesin PSP-I, a protein with a single CUB domain architecture, and promote its binding to heparin 10.1021/bi052621g

Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: Insight into the evolution of the snake venom integrin-inhibition system 10.1042/BJ20051678

Conformational diversity of the Goodpasture antigen, the noncollagenous-1 domain of the alpha3 chain of collagen IV. 10.1002/pmic.200500495

Out of Cordoba. 10.1002/pmic.200690050

Production and characterisation of recombinant forms of human pulmonary surfactant protein C (SP-C): Structure and surface activity 10.1016/j.bbamem.2006.03.005

Analysis of porcine peripheral blood mononuclear cells proteome by 2-DE and MS: analytical and biological variability in the protein expression level and protein identification. 10.1002/pmic.200500386

Isolation and characterization of a new agglutinin from the red marine alga Hypnea cervicornis J. Agardh 10.1139/o05-152

The nitrate/nitrite ABC transporter of Phormidium laminosum: Phosphorylation state of NrtA is not involved in its substrate binding activity 10.1016/j.bbagen.2005.12.011

Dissecting the protective effect of the seminal plasma spermadhesin PSP-I/PSP-II on boar sperm functionality 10.2164/jandrol.05170

Immunolocalization and possible functional role of PSP-I/PSP-II heterodimer in highly extended boar spermatozoa 10.2164/jandrol.106.000539

cDNA cloning and functional expression of jerdostatin, a novel RTS-disintegrin from Trimeresurus jerdonii and a specific antagonist of the alpha1beta1 integrin. 10.1074/jbc.M509738200

Analysis of the stability of the spermadhesin PSP-I/PSP-II heterodimer. Effects of Zn2+ and acidic pH. 10.1111/j.1742-4658.2005.04974.x

Snake venomics: Comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina 10.1002/pmic.200402024

Crystallization and preliminary X-ray diffraction analysis of HML, a lectin from the red marine alga Hypnea musciformis 10.1107/S1744309105033671

The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain 10.1016/j.jmb.2005.08.055

Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death 10.1111/j.1471-4159.2005.03235.x

HCA and HML isolated from the red marine algae Hypnea cervicornis and Hypnea musciformis define a novel lectin family 10.1110/ps.051498505

Report on the first congress of the Spanish Proteomics Society 10.1002/pmic.200500425

Hydrodynamic liver gene transfer mechanism involves transient sinusoidal blood stasis and massive hepatocyte endocytic vesicles 10.1038/sj.gt.3302469

Snake venom disintegrins: Evolution of structure and function 10.1016/j.toxicon.2005.02.024

Conformation and concerted dynamics of the integrin-binding site and the C-terminal region of echistatin revealed by homonuclear NMR 10.1042/BJ20041343

Energetics of 5-bromo-4-chloro-3-indolyl-α-D-mannose binding to the Parkia platycephala seed lectin and its use for MAD phasing 10.1107/S1744309105004835

Boar spermatozoa in the oviduct 10.1016/j.theriogenology.2004.09.028

Structure-function correlations of snake venom disintegrins 10.2174/1381612053381783

Structural determinants of the selectivity of KTS-disintegrins for the α1β1 integrin 10.1016/j.febslet.2004.10.050

Crystallization and preliminary X-ray diffraction analysis of the lectin from Canavalia gladiata seeds 10.1107/S0907444904014489

Lebectin, a novel C-type lectin from Macrovipera lebetina venom inhibits integrin-adhesion, migration and invasion of human tumour cells 10.1038/labinvest.3700088

Increased protein kinase A regulatory subunit content and cGMP binding in erythrocyte membranes in liver cirrhosis 10.1016/j.jhep.2004.01.023

Antagonists Mo and Cu in a heterometallic cluster present on a novel protein (orange protein) isolated from Desulfovibrio gigas 10.1016/j.jinorgbio.2003.12.002

Expression of a plant serine O-acetyltransferase in Saccharomyces cerevisiae confers osmotic tolerance and creates an alternative pathway for cysteine biosynthesis 10.1002/yea.1076

Structural Requirements of MLD-Containing Disintegrins for Functional Interaction with α4/β1 and α9β1 Integrins 10.1021/bi035853t

Monoclonal Antibodies against the Tn-Specific Isolectin B4 from Vicia villosa Seeds: Characterization of the Epitope of the Blocking Antibody VV34 10.1089/153685904322772015

Snake venomics: Characterization of protein families in Sistrurus barbouri venom by cysteine mapping, N-terminal sequencing, and tandem mass spectrometry analysis 10.1002/pmic.200300628

Seed lectin from Pisum arvense: Isolation, biochemical characterization and amino acid sequence 10.2174/0929866033478591

Concerted Motions of the Integrin-binding Loop and the C-terminal Tail of the Non-RGD Disintegrin Obtustatin 10.1074/jbc.M307030200

Influence of porcine spermadhesins on the susceptibility of boar spermatozoa to high dilution 10.1095/biolreprod.103.016527

Isolation of two novel mannan- and L-fucose-binding lectins from the green alga Enteromorpha prolifera: Biochemical characterization of EPL-2 10.1016/S0003-9861(03)00232-7

Snake venom disintegrins: Novel dimeric disintegrins and structural diversification by disulphide bond engineering 10.1042/BJ20021739

NMR solution structure of the non-RGD disintegrin obtustatin 10.1016/S0022-2836(03)00371-1

Porcine spermadhesin PSP-I/PSP-II stimulates macrophages to release a neutrophil chemotactic substance: Modulation by mast cells 10.1095/biolreprod.102.013425

Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa 10.1110/ps.0230203

Role of an intrasubunit disulfide in the association state of the cytosolic homo-oligomer methionine adenosyltransferase 10.1074/jbc.M210177200

Spermadhesin PSP-I/PSP-II heterodimer and its isolated subunits induced neutrophil migration into the peritoneal cavity of rats 10.1095/biolreprod.102.007013

Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: A homologue of human PSA 10.1016/S0022-2836(02)00705-2

Sperm coating mechanism from the 1.8 Å crystal structure of PDC-109-phosphorylcholine complex 10.1016/S0969-2126(02)00751-7

Purification and characterization of a new lectin from the red marine alga Hypnea musciformis. 10.2174/0929866023408931

The presence of the WGD motif in CC8 heterodimeric disintegrin increases its inhibitory effect on αIIbβ3, αvβ3, and α5β1 integrins 10.1021/bi015627o

Characterization of a monomeric disintegrin, ocellatusin, present in the venom of the Nigerian carpet viper, Echis ocellatus 10.1016/S0014-5793(02)02233-0

Expression and purification of the recombinant ConBr (Canavalia brasiliensis lectin) produced in Escherichia coli cells 10.2174/0929866023408968

Purification and partial characterization of a lectin from Canavalia grandiflora benth. seeds 10.2174/0929866023409002

Purification, crystallization and identification by X-ray analysis of a prostate kallikrein from horse seminal plasma 10.1107/S0907444901009805

The amino-acid sequence of the glucose/mannose-specific lectin isolated from Parkia platycephala seeds reveals three tandemly arranged jacalin-related domains 10.1046/j.1432-1327.2001.02368.x

Crystal structure of native and Cd/Cd-substituted Dioclea guianensis seed lectin. A novel manganese-binding site and structural basis of dimer-tetramer association 10.1006/jmbi.2001.4814

Characterization of the sugar-binding specificity of the toxic lectins isolated from Abrus pulchellus seeds 10.1023/A:1014812114450

Purification, chemical, and immunochemical properties of a new lectin from Mimosoideae (Parkia discolor). 10.1080/10826060008544966

Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin. 10.1074/jbc.M003209200

The disulfide bond pattern of catrocollastatin C, a disintegrin-like/cysteine-rich protein isolated from Crotalus atrox venom. 10.1110/ps.9.7.1365

Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds 10.1046/j.1432-1327.2000.01141.x

Disulphide-bond pattern and molecular modelling of the dimeric disintegrin EMF-10, a potent and selective integrin alpha5beta1 antagonist from Eristocophis macmahoni venom. 10.1042/0264-6021:3450573

Biophysical study of the perturbation of model membrane structure caused by seminal plasma protein PDC-109 10.1006/abbi.1999.1593

The amino acid sequence of the agglutinin isolated from the red marine alga Bryothamnion triquetrum defines a novel lectin structure. 10.1007/PL00000696

Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins. 10.1074/jbc.274.53.37809

Structural characterization of the oligosaccharide chains of native and crystallized boar seminal plasma spermadhesin PSP-I and PSP-II glycoforms 10.1046/j.1432-1327.1999.00766.x

Platelet integrin GPIIb/IIIa: structure-function correlations. An update and lessons from other integrins. 10.1111/j.1525-1373.1999.09993.x

Structural and functional characterization of EMF10, a heterodimeric disintegrin from Eristocophis macmahoni venom that selectively inhibits α5β1 integrin 10.1021/bi9906930

The N-terminus of collagenase MMP-8 determines superactivity and inhibition: A relation of structure and function analyzed by biomolecular interaction analysis 10.1021/bi982618f

EC3, a novel heterodimeric disintegrin from Echis carinatus venom, inhibits α4 and α5 integrins in an RGD-independent manner 10.1074/jbc.274.18.12468

Molecular characterization and crystallization of Diocleinae lectins 10.1016/S0167-4838(99)00020-5

Characterisation of the conformational and quaternary structure-dependent heparin-binding region of bovine seminal plasma protein PDC-109 10.1016/S0014-5793(99)00099-X

Crystal structure of the first dissimilatory nitrate reductase at 1.9 Å solved by MAD methods 10.1016/S0969-2126(99)80010-0

ATP sulfurylases from sulfate-reducing bacteria of the genus Desulfovibrio. A novel metalloprotein containing cobalt and zinc 10.1021/bi9816709

Purification and characterization of a lectin from seeds of Vatairea macrocarpa duke 10.1016/S0031-9422(98)00144-7

Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor 10.1093/emboj/17.17.5238

Binding of mannose-6-phosphate and heparin by boar seminal plasma PSP-II, a member of the spermadhesin protein family 10.1016/S0014-5793(98)00772-8

Thermodynamic stability of two variants of xylanase (Xys1) from Streptomyces halstedii JM8. 10.1046/j.1432-1327.1998.2530462.x

Molecular cloning and characterization of P47, a novel boar sperm-associated zona pellucida-binding protein homologous to a family of mammalian secretory proteins. 10.1095/biolreprod58.4.1057

Amino acid sequence, glycan structure, and proteolytic processing of the lectin of Vatairea macrocarpa seeds 10.1016/S0014-5793(98)00243-9

Biophysical characterization of the interaction of bovine seminal plasma protein PDC-109 with phospholipid vesicles 10.1007/s002490050108

Immunoelectronmicroscopic imaging of spermadhesin AWN epitopes on boar spermatozoa bound in vivo to the zona pellucida 10.1071/RD98111

The 2.4 Å resolution crystal structure of boar seminal plasma PSP-I/PSP-II: A zona pellucida-binding glycoprotein heterodimer of the spermadhesin family built by a CUB domain architecture 10.1006/jmbi.1997.1424

Crystal structure of acidic seminal fluid protein (aSFP) at 1.9 Å resolution: A bovine polypeptide of the spermadhesin family 10.1006/jmbi.1997.1423

Conformational features and thermal stability of bovine seminal plasma protein PDC-109 oligomers and phosphorylcholine-bound complexes. 10.1111/j.1432-1033.1997.00735.x

Biochemical and conformational characterisation of HSP-3, a stallion seminal plasma protein of the cysteine-rich secretory protein (CRISP) family 10.1016/S0014-5793(97)01514-7

The crystal structures of two spermadhesins reveal the CUB domain fold. 10.1038/nsb1097-783

The disulphide bond pattern of bitistatin, a disintegrin isolated from the venom of the viper Bitis arietans 10.1016/S0014-5793(97)01203-9

Monoclonal antibodies against boar sperm zona pellucida-binding protein awn-1. Characterization of a continuous antigenic determinant and immunolocalization of AWN epitopes in inseminated sows 10.1095/biolreprod57.4.735

Molecular cloning and characterization of ConBr, the lectin of Canavalia brasiliensis seeds. 10.1111/j.1432-1033.1997.00043.x

Crystallization and preliminary x-ray diffraction analysis of bovine seminal plasma PCD-109, a protein composed of two fibronectin type II domains 10.1002/(SICI)1097-0134(199707)28:3<454::AID-PROT14>3.0.CO;2-G

Isolation and characterization of heparin- and phosphorylcholine-binding proteins of boar and stallion seminal plasma. Primary structure of porcine pB1 10.1016/S0014-5793(97)00344-X

The crystal structure of Canavalia brasiliensis lectin suggests a correlation between its quaternary conformation and its distinct biological properties from Concanavalin A 10.1016/S0014-5793(97)00137-3

Identification of bovine zona pellucida glycoproteins. 10.1002/(SICI)1098-2795(199703)46:3<344::AID-MRD13>3.3.CO;2-B

Crystallization and preliminary X-ray diffraction studies of aSFP, a bovine seminal plasma protein with a single CUB domain architecture. 10.1002/pro.5560060323

Fractionation and characterization of boar seminal plasma spermadhesin PSP-II glycoforms reveal the presence of uncommon N-acetylgalactosamine-containing N-linked oligosaccharides 10.1023/A:1018506208616

Chemical cross-linking detects different conformational arrangements of platelet integrin α(IIb)β(III) (gpIIb/IIIa) 10.1006/bbrc.1996.1825

The primary structure of BSP-30K, a major lipid-, gelatin-, and heparin-binding glycoprotein of bovine seminal plasma 10.1016/S0014-5793(96)01310-5

Primary structure of stallion seminal plasma protein HSP-7, a zona-pellucida-binding protein of the spermadhesin family. 10.1111/j.1432-1033.1996.0636r.x

Importance of the structure of the RGD-containing loop in the disintegrins echistatin and eristostatin for recognition of αIIbβ3 and αvβ3 integrins 10.1016/0014-5793(96)00716-8

A procedure for the large-scale isolation of major bovine seminal plasma proteins 10.1006/prep.1996.0073

The structure of the O-linked carbohydrate chain of bovine seminal plasma protein PDC-109 revised by H-NMR spectroscopy A correction. 10.1016/0014-5793(96)00448-6

Characterization of representative enzymes from a sulfate reducing bacterium implicated in the corrosion of steel 10.1006/bbrc.1996.0610

Crystallization and preliminary X-ray diffraction analysis of boar seminal plasma spermadhesin PSP-I/PSP-II, a heterodimer of two CUB domains 10.1016/0014-5793(96)00133-0

Mapping the heparin-binding domain of boar spermadhesins 10.1016/0014-5793(95)01513-2

Analysis of the structural organization and thermal stability of two spermadhesins. Calorimetric, circular dichroic and Fourier-transform infrared spectroscopic studies. 10.1111/j.1432-1033.1995.887_a.x

Identification by Affinity Chromatography of Boar Sperm Membrane-Associated Proteins Bound to Immobilized Porcine Zona Pellucida. Mapping of the Phosphorylethanolamine-Binding Region of Spermadhesin AWN 10.1515/bchm3.1995.376.12.733

Advanced ovulation in gilts by the intrauterine application of a low molecular mass pronase-sensitive fraction of boar seminal plasma. 10.1530/jrf.0.1050247

Immunohistochemical localization of spermadhesin AWN in the porcine male genital tract 10.1007/BF00319144

Effect of glycosylation on the heparin-binding capability of boar and stallion seminal plasma proteins 10.1016/0021-9673(95)00011-B

Boar spermadhesin AWN-1. Oligosaccharide and zona pellucida binding characteristics. 10.1111/j.1432-1033.1995.tb20567.x

Boar spermadhesin PSP-II: Location of posttranslational modifications, heterodimer formation with PSP-I glycoforms and effect of dimerization on the ligand-binding capabilities of the subunits 10.1016/0014-5793(95)00452-F

Interaction of Non-Aggregated Boar AWN-1 and AQN-3 with Phospholipid Matrices. A Model for Coating of Spermadhesins to the Sperm Surface 10.1515/bchm3.1995.376.4.237

On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor. 10.3181/00379727-208-43863A

Immunocytochemical characterization of porcine zona pellucida during follicular development 10.1007/BF00215296

Mass spectrometric analysis of the phosphorylation state of human platelet glycoprotein IIIa 10.3109/09537109509023565

Localization and structural characterization of an oligosaccharide O-linked to bovine PDC-109 Quantitation of the glycoprotein in seminal plasma and on the surface of ejaculated and capacitated spermatozoa 10.1016/0014-5793(94)00768-3

Characterization of the cross-linking site of disintegrins albolabrin, bitistatin, echistatin, and eristostatin on isolated human platelet integrin GPIIb/IIIa 10.1006/bbrc.1994.1903

Immunolocalization and Quantitation of Acidic Seminal Fluid Protein (aSFP) in Ejaculated, Swim-up, and Capacitated Bull Spermatozoa 10.1515/bchm3.1994.375.7.457

Bovine seminal plasma ASFP: Localization of disulfide bridges and detection of three different isoelectric forms 10.1016/0014-5793(94)00362-9

Primary sequence, oxidation-reduction potentials and tertiary-structure prediction of Desulfovibrio desulfuricans ATCC 27774 flavodoxin. 10.1111/j.1432-1033.1994.tb18703.x

Characterization of two glycosylated boar spermadhesins 10.1111/j.1432-1033.1993.tb18426.x

Characterization of AWN-1 glycosylated isoforms helps define the zona pellucida and serine proteinase inhibitor-binding region on boar spermadhesins 10.1016/0014-5793(93)81675-P

Glycoprotein lib peptide 656-667 mimics the fibrinogen γ chain 402-411 binding site on platelet integrin GPIIb/IIIa 10.1016/0014-5793(93)80454-3

Localization of an O-glycosylation site in the α-subunit of the human platelet integrin GPIIb/IIIa involved in Baka (HPA-3a) alloantigen expression 10.1016/0014-5793(93)80959-X

Isolation and biochemical characterization of heparin-binding proteins from boar seminal plasma: a dual role for spermadhesins in fertilization. 10.1002/mrd.1080350107

The disulfide bridge pattern of snake venom disintegrins, flavoridin and echistatin 10.1016/0014-5793(92)80797-K

Localization of the cross-linking sites of RGD and KQAGDV peptides to the isolated fibrinogen receptor, the human platelet integrin glicoprotein IIb/IIIa. Influence of peptide length 10.1111/j.1432-1033.1992.tb16982.x

The complete primary structure of the boar spermadhesin AQN-1, a carbohydrate-binding protein involved in fertilization. 10.1111/j.1432-1033.1992.tb16822.x

The complete primary structure of the spermadhesin AWN, a zona pellucida-binding protein isolated from boar spermatozoa 10.1016/0014-5793(92)80848-B

Boar spermadhesins AQN-1 and AWN are sperm-associated acrosin inhibitor acceptor proteins 10.1016/0014-5793(92)80164-C

Isolation and biochemical characterization of two isoforms of a boar sperm zona pellucida-binding protein 10.1016/0167-4838(92)90382-N

Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L 10.1016/0014-5793(92)80339-I

The complete primary structure of three isoforms of a boar sperm-associated acrosin inhibitor 10.1016/0014-5793(92)80347-J

Characterisation of the N-linked oligosaccharides of the light chain of human glycoprotein IIb by f.a.b.-m.s. 10.1016/0008-6215(91)80054-Q

The amino acid sequence of AQN-3, a carbohydrate-binding protein isolated from boar sperm Location of disulphide bridges 10.1016/0014-5793(91)81097-R

Arg-Gly-Asp constrained within cyclic pentapoptides Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1 10.1016/0014-5793(91)81101-D

A large-scale procedure for the isolation of integrin GPIIb/IIIa, the human platelet fibrinogen receptor 10.1016/1046-5928(91)90080-3

Identification of the disulfide bond pattern in albolabrin, an RGD-containing peptide from the venom of Trimeresurus albolabris: significance for the expression of platelet aggregation inhibitory activity. 10.1021/bi00235a016

Isolation and biochemical characterization of a zona pellucida-binding glycoprotein of boar spermatozoa 10.1016/0014-5793(91)80233-S

Complete localization of the disulfide bridges and glycosylation sites in boar sperm acrosin 10.1016/0014-5793(90)81458-Z

Characterization of the β-chain N-terminus heterogeneity and the α-chain C-terminus of human platelet GPIIb. Posttranslational cleavage sites 10.1016/0014-5793(90)80443-M

C-terminal amino acid determination of the transmembrane subunits of the human platelet fibrinogen receptor, the GPIIb/IIIa complex 10.1016/0014-5793(90)80701-J

Molecular characterization of human platelet glycoproteins IIIa and IIb and the subunits of the latter 10.1007/BF00256354

Omics meets biology: Application to the design and preclinical assessment of antivenoms 10.3390/toxins6123388

First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis 10.1016/j.toxicon.2014.11.235

Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil 10.1016/j.jprot.2014.11.011

NMR structure of bitistatin - A missing piece in the evolutionary pathway of snake venom disintegrins 10.1111/febs.13138

Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka 10.1016/j.jprot.2014.07.019

The magic of words 10.1016/j.jprot.2014.06.018

Preclinical efficacy of Australian antivenoms against the venom of the small-eyed snake, Micropechis ikaheka, from Papua New Guinea: An antivenomics and neutralization study 10.1016/j.jprot.2014.06.016

Challenges and prospects of proteomics of non-model organisms 10.1016/j.jprot.2014.04.034

A multicomponent strategy to improve the availability of antivenom for treating snakebite envenoming 10.2471/BLT.13.132431

Book review 10.1016/j.jprot.2014.05.020

Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii 10.1016/j.biochi.2016.03.004

Ecological proteomics: is the fi eld ripe for integrating proteomics into evolutionary ecology research? 10.1016/j.jprot.2016.01.020

Snake venomics and antivenomics of bothrops diporus, a medically important pitviper in northeastern Argentina 10.3390/toxins8010009

A bright future for integrative venomics 10.1016/j.toxicon.2015.10.024

Computational proteomics: Integrating mass spectral data into a biological context 10.1016/j.jprot.2015.10.013

Constructing comprehensive venom proteome reference maps for integrative venomics 10.1586/14789450.2015.1073590

Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria 10.1016/j.toxicon.2015.09.027

A Call for Incorporating Social Research in the Global Struggle against Snakebite 10.1371/journal.pntd.0003960

The proteome quest to understand biology and disease (HUPO 2014) 10.1016/j.jprot.2015.09.025

Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids 10.1016/j.toxicon.2015.08.016

Quaternary structure of Dioclea grandiflora lectin assessed by equilibrium sedimentation and crystallographic analysis of recombinant mutants 10.1016/j.febslet.2015.07.020

Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest 10.1016/j.jprot.2015.04.029

Venom proteomics of indonesian king cobra, ophiophagus hannah: Integrating top-down and bottom-up approaches 10.1021/acs.jproteome.5b00305

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage 10.1371/journal.pntd.0003731

Comparative venomics of the Prairie Rattlesnake (Crotalus viridis viridis) from Colorado: Identification of a novel pattern of ontogenetic changes in venom composition and assessment of the immunoreactivity of the commercial antivenom CroFab® 10.1016/j.jprot.2015.03.015

Structures of integrin domains and concerted conformational changes in the bidirectional signaling mechanism of αIIbβ3 10.1177/153537020422900805

Micro-heterogeneity and molecular assembly of the haemagglutinins from the red algae Bryothamnion seaforthii and B. triquetrum from the Caribbean Sea 10.1080/09670260601012438

Influence of seminal plasma PSP-I/PSP-II spermadhesin on pig gamete interaction 10.1017/S0967199405003072

Immobilization-stabilization of enzymes; variables that control the intensity of the trypsin (amine)-agarose (aldehyde) multipoint attachment 10.1016/0141-0229(89)90019-7

Erratum: Snake venomics of crotalus tigris: The minimalist toxin arsenal of the deadliest nearctic rattlesnake venom. Evolutionary clues for generating a pan-specific antivenom against crotalid type II venoms (Journal of Proteome Research (2012) 11:2 (1382-1390) DOI: 10.1021/pr201021d) 10.1021/pr5009543

Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus 10.1016/j.biochi.2014.10.010

Crystallization and preliminary X-ray diffraction analysis of the seed lectin from Parkia platycephala 10.1107/S0907444901018236

Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki 10.1016/j.bbagen.2015.02.002

Identification of bovine zona pellucida glycoproteins 10.1002/(SICI)1098-2795(199703)46:3<344::AID-MRD13>3.0.CO;2-Z

Substrate specificity of the Chamaerops excelsa palm tree peroxidase. A steady-state kinetic study 10.1016/j.molcatb.2011.09.005

Formulation and delivery of proteins and peptides: Cleland J.L. and Langer R. (Eds). ACS Symposium Series 567. Washington, DC: American Chemical Society (1994) 10.1016/0041-0101(95)90084-5

Analysis of O-glycosylation 10.1007/978-1-60327-84-7_20

Brief history and molecular determinants of snake venom disintegrin evolution 10.1007/978-90-481-9295-3_18

Journal of Proteomics - The first nine months and 6 issues after its Big Bang 10.1016/j.jprot.2008.11.013

SEProt-EuPA joint meeting 'Proteomics and Pathology: Linking both sides of the Atlantic Ocean' 10.1002/jms.1338

Varia 10.1007/BF00325734

Identification of Porcine Oocyte 55 kDa α and β Proteins within the Zona Pellucida Glycoprotein Families Indicates that Oocyte Sperm Receptor Activity is Associated with Different Zona Pellucida Proteins in Different Mammalian Species 10.1515/bchm3.1993.374.7-12.411

Snake venomics, antivenomics, and venom phenotyping: The ménage à trois of proteomic tools aimed at understanding the biodiversity of venoms 10.1007/978-90-481-9295-3_4

Glycosylated Boar Spermadhesin AWN-1 Isoforms. Biological Origin, Structural Characterization by Lectin Mapping, Localization of O-Glycosylation Sites, and Effect of Glycosylation on Ligand Binding 10.1515/bchm3.1994.375.10.667

Arid environments: Opportunities for studying co-evolutionary patterns of scorpion venoms in predator-prey systems 10.1016/j.jaridenv.2014.02.013

Quantitation of boar spermadhesins in accessory sex gland fluids and on the surface of epididymal, ejaculated and capacitated spermatozoa 10.1016/0304-4165(94)90026-4

Conformational diversity of the Goodpasture antigen, the noncollagenous-1 domain of the α3 chain of collagen IV (Proteomics 6 (S1) (S237-S244) DOI: 10.1002/pmic.200500495) 10.1002/pmic.200790107

Venomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venoms 10.3390/toxins8060178

Top-down venomics of the East African green mamba, Dendroaspis angusticeps, and the black mamba, Dendroaspis polylepis, highlight the complexity of their toxin arsenals 10.1016/j.jprot.2016.06.018

Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics 10.1016/j.toxicon.2016.06.022

Is hybridization a source of adaptive venom variation in rattlesnakes? A test, using a crotalus scutulatus × viridis hybrid zone in Southwestern New Mexico 10.3390/toxins8060188

Identification of the major proteins present in the seminal plasma of European eel, and how hormonal treatment affects their evolution. Correlation with sperm quality 10.1016/j.cbpa.2016.06.025

Insights into the evolution of a snake venom multi-gene family from the genomic organization of Echis ocellatus SVMP genes 10.3390/toxins8070216

Isolation and Biochemical Characterization of Stallion Seminal‐plasma Proteins 10.1111/j.1439-0531.1994.tb00588.x

Proteomics and antivenomics of Papuan black snake (Pseudechis papuanus) venom with analysis of its toxicological profile and the preclinical efficacy of Australian antivenoms 10.1016/j.jprot.2016.09.007

Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses 10.1016/j.toxicon.2016.09.008

Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis) 10.1016/j.jprot.2016.10.006

Selection for higher fertility reflects in the seminal fluid proteome of modern domestic chicken 10.1016/j.cbd.2016.10.006

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus 10.1016/j.bbagen.2017.01.020

Third Generation Antivenomics: Pushing the Limits of the In Vitro Preclinical Assessment of Antivenoms 10.3390/toxins9050158

Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead 10.3390/toxins9050163

Venom On-a-Chip: A Fast and Efficient Method for Comparative Venomics 10.3390/toxins9060179

Absolute venomics: Absolute quantification of intact venom proteins through elemental mass spectrometry 10.1016/j.jprot.2017.06.001

Integrated Venomics and Venom Gland Transcriptome Analysis of Juvenile and Adult Mexican Rattlesnakes Crotalus simus, C. tzabcan, and C. culminatus Revealed miRNA-modulated Ontogenetic Shifts 10.1021/acs.jproteome.7b00414

Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms 10.1186/s40409-017-0117-8

Antivenomics: A Proteomics Tool for Studying the Immunoreactivity of Antivenoms 10.1002/9783527673391.ch7

Venomics: Integrative venom proteomics and beyond 10.1042/BCJ20160577

Protein-species quantitative venomics: Looking through a crystal ball 10.1186/s40409-017-0116-9

Elemental Mass Spectrometry for Absolute Intact Protein Quantification without Protein-Specific Standards: Application to Snake Venomics 10.1021/acs.analchem.6b02585

Distribution of RPTLN Genes Across Reptilia: Hypothesized Role for RPTLN in the Evolution of SVMPs 10.1093/icb/icw031

The challenge of integrating proximate and ultimate causes to reconstruct the natural histories of venoms: the evolutionary link 10.1080/14789450.2017.1242416

Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif 10.3390/toxins8100292

Drought tolerance in pinus halepensis seed sources as identified by distinctive physiological and molecular markers 10.3389/fpls.2017.01202

Erratum to “Absolute venomics: Absolute quantification of intact venom proteins through elemental mass spectrometry” (Journal of Proteomics (2017) 164 (33–42), (S187439191730204X), (10.1016/j.jprot.2017.06.001)) 10.1016/j.jprot.2017.07.009

Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms 10.1371/journal.pntd.0005793

Examination of biochemical and biological activities of Bothrops jararaca (Serpentes: Viperidae; Wied-Neuwied 1824) snake venom after up to 54 years of storage 10.1016/j.toxicon.2017.11.011

Snakebite envenoming. 10.1038/nrdp.2017.79

A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins 10.1111/pbi.12823

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms 10.1016/j.jprot.2017.08.016

Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam 10.1016/j.jprot.2017.12.020

Snakebite envenoming 10.1038/nrdp.2017.63

Toxin-resolved antivenomics-guided assessment of the immunorecognition landscape of antivenoms 10.1016/j.toxicon.2018.04.015

A novel pentameric phospholipase A2 myotoxin (PophPLA2) from the venom of the pit viper Porthidium ophryomegas 10.1016/j.ijbiomac.2018.06.028

Translational venomics: Third-Generation Antivenomics of Anti-Siamese Russell’s Viper, Daboia siamensis, Antivenom Manufactured in Taiwan CDC’s Vaccine Center 10.3390/tropicalmed3020066

Snake venomics–from low-resolution toxin-pattern recognition to toxin-resolved venom proteomes with absolute quantification 10.1080/14789450.2018.1500904

Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis 10.1038/s41598-018-29791-y

Venom gland transcriptomics and microRNA profiling of juvenile and adult yellow-bellied sea snake, Hydrophis platurus, from Playa del Coco (Guanacaste, Costa Rica) 10.1016/j.toxicon.2018.08.016

Defining the pathogenic threat of envenoming by South African shield-nosed and coral snakes (genus Aspidelaps), and revealing the likely efficacy of available antivenom 10.1016/j.jprot.2018.09.019

When one phenotype is not enough - divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species 10.1101/413831

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms 10.1038/s42003-018-0039-1

The Harderian gland transcriptomes of Caraiba andreae, Cubophis cantherigerus and Tretanorhinus variabilis, three colubroid snakes from Cuba 10.1016/j.ygeno.2018.11.026

Enhanced Universal Quantification of Biomolecules Using Element MS and Generic Standards: Application to Intact Protein and Phosphoprotein Determination 10.1021/acs.analchem.8b04731

Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards Bothrops lanceolatus venom 10.1016/j.toxcx.2018.100004

Vipera berus berus Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom 10.3390/toxins11020090

Journal of Proteomics turns 10: Happy anniversary! and beyond 10.1016/j.jprot.2019.03.002

New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America 10.1016/j.jprot.2019.03.014

When one phenotype is not enough: Divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species 10.1098/rspb.2018.2735

Comparative venomics of Brazilian coral snakes: Micrurus frontalis, Micrurus spixii spixii, and Micrurus surinamensis 10.1016/j.toxicon.2019.05.001

Phylovenomics of Daboia russelii across the Indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of antivenoms against venoms from India, Bangladesh and Sri Lanka 10.1016/j.jprot.2019.103443

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite 10.1101/717280

Glycobiology of Fertilization 10.1002/9783527614738.ch35

Toxinology 10.1007/978-94-007-6649-5

Estrategias proteómicas para hacer frente a la mordedura de serpiente 10.18567/sebbmdiv_rpc.2010.03.1

Analysis of O-Glycosylation 10.1385/1-59259-181-7:089

Towards an integrated omics approach to understand venom evolution 10.1016/j.toxicon.2013.08.011

Venomics and antivenomics of the poorly studied Brazil’s lancehead, Bothrops brazili (Hoge, 1954), from the Brazilian State of Pará 10.1590/1678-9199-jvatitd-2019-0103

Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite 10.1126/scitranslmed.aay8314

Venomics and biochemical analysis of the black-tailed horned pitviper, Mixcoatlus melanurus, and characterization of Melanurutoxin, a novel crotoxin homolog 10.1016/j.jprot.2020.103865

Comparative characterization of Viperidae snake venoms from Perú reveals two compositional patterns of phospholipase A2 expression. 10.1016/j.toxcx.2020.100044

Dagestan blunt-nosed viper, Macrovipera lebetina obtusa (Dwigubsky, 1832), venom. Venomics, antivenomics, and neutralization assays of the lethal and toxic venom activities by anti-Macrovipera lebetina turanica and anti-Vipera berus berus antivenoms 10.1016/j.toxcx.2020.100035

Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae) 10.1016/j.toxcx.2020.100030

The molecular basis of venom resistance in a rattlesnake-squirrel predator-prey system 10.1111/mec.15529

Venomics of the Duvernoy's gland secretion of the false coral snake Rhinobothryum bovallii (Andersson, 1916) and assessment of venom lethality towards synapsid and diapsid animal models 10.1016/j.jprot.2020.103882

Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras 10.1101/2020.07.08.192443

Danger in the Canopy. Comparative Proteomics and Bioactivities of the Venoms of the South American Palm Pit Viper Bothrops bilineatus Subspecies bilineatus and smaragdinus and Antivenomics of B. b. bilineatus (Rondônia) Venom against the Brazilian Pentabothropic Antivenom 10.1021/acs.jproteome.0c00337

Comparative proteomic profiling and functional characterization of venom pooled from captive crotalus durissus terrificus specimens and the Brazilian crotalic reference venom 10.1016/j.toxicon.2020.07.001

An evolutionary framework for venom variation patterns in terciopelo pitvipers (Bothrops asper), a model organism in toxinology 10.1016/j.toxicon.2019.10.029

The molecular basis of venom resistance in a rattlesnake-squirrel predator-prey system 10.1016/j.toxicon.2019.12.090

Convergent evolution of defensive venom components in spitting cobras 10.1016/j.toxicon.2019.12.059

Implications of snake venom variation on antivenom neutralization: The case of North American vipers 10.1016/j.toxicon.2019.12.014

Repurposing DMPS, a metal chelator, as a rapid field intervention for treating hemotoxic snakebite 10.1016/j.toxicon.2019.10.248

Comparative venomics of Brazilian coral snakes: Micrurus frontalis, Micrurus spixii spixii, and Micrurus surinamensis 10.1016/j.toxicon.2019.10.086

Snake venomics at the crossroads between ecological and clinical toxinology 10.1042/bio04106028

Venom variation in Bothrops asper lineages from North-Western South America 10.1016/j.jprot.2020.103945

The earless monitor lizard Lanthanotus borneensis - A venomous animal? 10.1016/j.toxicon.2020.11.013

Convergent evolution of pain-inducing defensive venom components in spitting cobras. 10.1126/science.abb9303

Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms 10.1371/journal.pntd.0009073

Seminal Plasma: Relevant for Fertility? 10.3390/ijms22094368

What's in a mass? 10.1042/BST20210288

Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance 10.1016/j.toxcx.2021.100070

Wolfgang Wüster

Wüster Wolfgang

ORCID: 0000-0002-4890-4311

Email: w.wuster@bangor.ac.uk

http://mefgl.bangor.ac.uk/staff/wuster.php

Complex cocktails: the evolutionary novelty of venoms 10.1016/j.tree.2012.10.020

Phylogeography of the widespread African puff adder (Bitis arietans) reveals multiple Pleistocene refugia in southern Africa 10.1111/mec.12157

Anonymous nuclear markers for the African adders (Serpentes: Viperidae: Bitis) 10.1007/s12686-012-9684-8

Dynamic evolution of venom proteins in squamate reptiles 10.1038/ncomms2065

The Origin and Evolution of Metalloproteinases in the Venom of Snakes 10.1016/j.toxicon.2012.04.050

The structural and functional diversification of the Toxicofera reptile venom system 10.1016/j.toxicon.2012.02.013

Venom lethality and diet: Differential responses of natural prey and model organisms to the venom of the saw-scaled vipers (Echis) 10.1016/j.toxicon.2011.10.015

Domain Loss Facilitates Accelerated Evolution and Neofunctionalization of Duplicate Snake Venom Metalloproteinase Toxin Genes 10.1093/molbev/msr091

Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa 10.1016/j.jprot.2011.05.027

Gene Tree Parsimony of Multilocus Snake Venom Protein Families Reveals Species Tree Conflict as a Result of Multiple Parallel Gene Loss 10.1093/molbev/msq302

On the generic classification of the rattlesnakes, with special reference to the Neotropical Crotalus durissus complex (Squamata: Viperidae) 10.1590/S1984-46702011000400001

Pre-Clinical Assays Predict Pan-African Echis Viper Efficacy for a Species-Specific Antivenom 10.1371/journal.pntd.0000851

What's your poison? 10.1038/hdy.2009.142

Coevolution of diet and prey-specific venom activity supports the role of selection in snake venom evolution 10.1098/rspb.2009.0048

Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts 10.1186/1471-2164-10-564

When continents collide: Phylogeny, historical biogeography and systematics of the medically important viper genus Echis (Squamata: Serpentes: Viperidae) 10.1016/j.ympev.2009.08.002

A nesting of vipers: Phylogeny and historical biogeography of the Viperidae (Squamata: Serpentes) 10.1016/j.ympev.2008.08.019

Multi-locus phylogeny and species delimitation of Australo-Papuan blacksnakes (Pseudechis Wagler, 1830: Elapidae: Serpentes) 10.1016/j.ympev.2016.09.005

Is Hybridization a Source of Adaptive Venom Variation in Rattlesnakes? A Test, Using a Crotalus scutulatus x viridis Hybrid Zone in Southwestern New Mexico 10.3390/toxins8060188

Phylogeny and diversification of mountain vipers (Montivipera, Nilson et al., 2001) triggered by multiple Plio-Pleistocene refugia and high-mountain topography in the Near and Middle East 10.1016/j.ympev.2016.04.025

Widespread convergence in toxin resistance by predictable molecular evolution 10.1073/pnas.1511706112

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms 10.1073/pnas.1405484111

Phylogeography of the Central American lancehead Bothrops asper (SERPENTES: VIPERIDAE). 10.1371/journal.pone.0187969

Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies 10.1016/j.toxlet.2017.08.020

Venom On-a-Chip: A Fast and Efficient Method for Comparative Venomics 10.3390/toxins9060179

Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis 10.1038/s41598-018-29791-y

Widespread vulnerability of Malagasy predators to the toxins of an introduced toad 10.1016/j.cub.2018.04.024

Integration of nuclear and mitochondrial gene sequences and morphology reveals unexpected diversity in the forest cobra (Naja melanoleuca) species complex in Central and West Africa (Serpentes: Elapidae) 10.11646/zootaxa.4455.1.3

When one phenotype is not enough – divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species 10.1101/413831

Taxonomy based on science is necessary for global conservation 10.1371/journal.pbio.2005075

Ancient habitat shifts and organismal diversification are decoupled in the African viper genusBitis(Serpentes: Viperidae) 10.1111/jbi.13578

When one phenotype is not enough: divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species 10.1098/rspb.2018.2735

Deconstructing compassionate conservation 10.1111/cobi.13366

Fangs for the Memories? A Survey of Pain in Snakebite Patients Does Not Support a Strong Role for Defense in the Evolution of Snake Venom Composition 10.3390/toxins12030201

Convergent evolution of pain-inducing defensive venom components in spitting cobras. 10.1126/science.abb9303

Crowdsourcing snake identification with online communities of professional herpetologists and avocational snake enthusiasts. 10.1098/rsos.201273

Evaluating taxonomic inflation: towards evidence-based species delimitation in Eurasian vipers (Serpentes: Viperinae) 10.1163/15685381-bja10007

Unexpected lack of specialisation in the flow properties of spitting cobra venom 10.1242/jeb.229229

Confronting taxonomic vandalism in biology: conscientious community self-organization can preserve nomenclatural stability 10.1093/biolinnean/blab009

An evaluation of the nomina for death adders (Acanthophis Daudin, 1803) proposed by Wells & Wellington (1985), and confirmation of A. cryptamydros Maddock et al., 2015 as the valid name for the Kimberley death adder 10.11646/zootaxa.4995.1.9

How do King Cobras move across a major highway? Unintentional wildlife crossing structures may facilitate movement 10.1101/2021.07.30.454480

Genome-wide data implicate terminal fusion automixis in king cobra facultative parthenogenesis 10.1038/s41598-021-86373-1

Citizen science and online data: Opportunities and challenges for snake ecology and action against snakebite 10.1016/j.toxcx.2021.100071

Jory van Thiel

van Thiel Jory

ORCID: 0000-0002-5187-7342

Convergent evolution of pain-inducing defensive venom components in spitting cobras 10.1126/science.abb9303

Samuel Robinson

Robinson Samuel / S. D. Robinson

ORCID: 0000-0002-3518-0377

https://scholar.google.com.au/citations?user=Klri8DgAAAAJ&hl=en

http://researchers.uq.edu.au/researcher/17592

Insulin as a weapon 10.1016/j.toxicon.2016.10.010

Stereoselective synthesis and structural elucidation of dicarba peptides 10.1039/c5cc10540d

A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold 10.1016/j.str.2015.11.015

Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons 10.3389/fncel.2015.00404

Hormone-like peptides in the venoms of marine cone snails 10.1016/j.ygcen.2015.07.012

Specialized insulin is used for chemical warfare by fish-hunting cone snails 10.1073/pnas.1423857112

Conotoxin gene superfamilies 10.3390/md12126058

Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets 10.1021/jm501126u

Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom 10.1016/j.jprot.2014.11.003

Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3 10.1111/febs.12835

Diversity of conotoxin gene superfamilies in the venomous snail, conus victoriae 10.1371/journal.pone.0087648

Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: Identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3 10.1124/jpet.109.156448

Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. 10.1021/cb4002393

The venom repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea 10.3390/md15050145

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering 10.1021/acs.biochem.7b00120

Structure and activity of contryphan-Vc2: Importance of the D-amino acid residue 10.1016/j.toxicon.2017.02.012

Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery 10.1080/14789450.2017.1377613

Venom peptides as pharmacological tools and therapeutics for diabetes 10.1016/j.neuropharm.2017.07.001

Discovery of novel conotoxin candidates using machine learning 10.3390/toxins10120503

Buzz kill: Function and proteomic composition of venom from the giant assassin fly Dolopus genitalis (Diptera: Asilidae) 10.3390/toxins10110456

Entomo-venomics: The evolution, biology and biochemistry of insect venoms 10.1016/j.toxicon.2018.09.004

Conopeptides promote itch through human itch receptor hMgprX1 10.1016/j.toxicon.2018.09.002

A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family 10.1126/sciadv.aau4640

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor 10.7554/eLife.41574

Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago 10.3390/md17080432

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework. 10.1074/jbc.ra119.007491

NaV 1.6 regulates excitability of mechanosensitive sensory neurons. 10.1113/jp278148

Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug platymeris rhadamanthus 10.3390/toxins11110673

An integrated proteomic and transcriptomic analysis reveals the venom complexity of the bullet ant Paraponera clavata 10.3390/toxins12050324

Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe 10.3390/BIOMEDICINES8060155

Pharmacology and therapeutic potential of venom peptides 10.1016/j.bcp.2020.114207

It takes two: Dimerization is essential for the broad-spectrum predatory and defensive activities of the venom peptide Mp1a from the jack jumper ant Myrmecia pilosula 10.3390/BIOMEDICINES8070185

Neurotoxic peptides from the venom of the giant Australian stinging tree 10.1126/sciadv.abb8828

Convergent evolution of pain-inducing defensive venom components in spitting cobras 10.1126/science.abb9303

High-Throughput Fluorescence Assays for Ion Channels and GPCRs 10.1007/978-3-030-12457-1_3

Deadly Proteomes: A Practical Guide to Proteotranscriptomics of Animal Venoms 10.1002/pmic.201900324

Transcriptomic Profiling Reveals Extraordinary Diversity of Venom Peptides in Unexplored Predatory Gastropods of the Genus Clavus 10.1093/gbe/evaa083

Roel Wouters

Wouters Roel / Roel M Wouters

ORCID: 0000-0002-2320-3412

Convergent evolution of pain-inducing defensive venom components in spitting cobras 10.1126/science.abb9303

Ricardo da Silva

da Silva Ricardo

ORCID: 0000-0001-6378-0479

http://ccbl.fcfrp.usp.br

Computational Removal of Undesired Mass Spectral Features Possessing Repeat Units via a Kendrick Mass Filter 10.1007/s13361-018-2069-9

Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome 10.1186/s40168-019-0636-3

A comparative venomic fingerprinting approach reveals that galling and non-galling fig wasp species have different venom profiles 10.1371/journal.pone.0207051

American Gut: an Open Platform for Citizen Science Microbiome Research 10.1128/mSystems.00031-18

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation 10.1021/acs.jnatprod.7b00737

Chemical profiling of two congeneric sea mat corals along the Brazilian coast: adaptive and functional patterns 10.1039/c7cc08411k

Niche partitioning of a pathogenic microbiome driven by chemical gradients 10.1126/sciadv.aau1908

Propagating annotations of molecular networks using in silico fragmentation 10.1371/journal.pcbi.1006089

Targeted Isolation of Neuroprotective Dicoumaroyl Neolignans and Lignans from Sageretia theezans Using in Silico Molecular Network Annotation Propagation-Based Dereplication 10.1021/acs.jnatprod.8b00292

Coupling Targeted and Untargeted Mass Spectrometry for Metabolome-Microbiome-Wide Association Studies of Human Fecal Samples 10.1021/acs.analchem.7b01381

Global chemical analysis of biology by mass spectrometry 10.1038/s41570-017-0054

High-Resolution Liquid Chromatography Tandem Mass Spectrometry Enables Large Scale Molecular Characterization of Dissolved Organic Matter 10.3389/fmars.2017.00405

Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols 10.1021/acsjnatprod.6b00722

Three-Dimensional Microbiome and Metabolome Cartography of a Diseased Human Lung 10.1016/j.chom.2017.10.001

Application of MALDI Mass Spectrometry in Natural Products Analysis 10.1055/s-0042-104800

From Sample to Multi-Omics Conclusions in under 48 Hours 10.1128/mSystems.00038-16

Lifestyle chemistries from phones for individual profiling 10.1073/pnas.1610019113

A metabolomic protocol for plant systematics by matrix-assisted laser-desorption/ionization time-of flight mass spectrometry 10.1016/j.aca.2015.01.002

Illuminating the dark matter in metabolomics 10.1073/pnas.1516878112

Mass spectrometry in plant metabolomics strategies: from analytical platforms to data acquisition and processing 10.1039/c3np70086k

ProbMetab: an R package for Bayesian probabilistic annotation of LC-MS-based metabolomics 10.1093/bioinformatics/btu019

Queen signals in a stingless bee: suppression of worker ovary activation and spatial distribution of active compounds 10.1038/srep07449

Comprehensive mass spectrometry-guided phenotyping of plant specialized metabolites reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1111/tpj.14292

Molecular and Microbial Microenvironments in Chronically Diseased Lungs Associated with Cystic Fibrosis 10.1128/MSYSTEMS.00375-19

Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/J.FOODCHEM.2019.125290

In silico annotation of discriminative markers of three Zanthoxylum species using molecular network derived annotation propagation 10.1016/J.FOODCHEM.2019.05.099

Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation 10.1021/ACS.JNATPROD.8B00916

The impact of skin care products on skin chemistry and microbiome dynamics 10.1186/S12915-019-0660-6

Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L 10.3389/FPLS.2019.00846

Initial Development toward Non-Invasive Drug Monitoring via Untargeted Mass Spectrometric Analysis of Human Skin 10.1021/ACS.ANALCHEM.8B05854

Mass spectrometry searches using MASST 10.1038/s41587-019-0375-9

Differences in Cystic Fibrosis-Associated Burkholderia spp. Bacteria Metabolomes after Exposure to the Antibiotic Trimethoprim 10.1021/acsinfecdis.9b00513

Global chemical effects of the microbiome include new bile-acid conjugations 10.1038/s41586-020-2047-9

Assessing specialized metabolite diversity of Alnus species by a digitized LC–MS/MS data analysis workflow 10.1016/j.phytochem.2020.112292

Feature-based molecular networking in the GNPS analysis environment 10.1038/s41592-020-0933-6

Time-Scale Shifting of Volatile Semiochemical Levels in Wild Type Lychnophora ericoides (Brazilian arnica) and Pollinator Records 10.1055/a-1320-4556

Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells 10.1038/s41419-020-03275-2

A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria 10.3390/md19010020

Convergent evolution of pain-inducing defensive venom components in spitting cobras 10.1126/science.abb9303

Chemical Gradients of Plant Substrates in an Atta texana Fungus Garden 10.1128/msystems.00601-21

REDES MOLECULARES: UMA ANÁLISE SOBRE ANOTAÇÕES E DESCOBERTA DE NOVOS ATIVOS 10.21577/0100-4042.20170777

CHAPTER 10. Perspectives for the Future 10.1039/9781788010399-00264

CHAPTER 3. Metabolomics 10.1039/9781788010399-00057

Mass Spectrometry in Chemical Biology 10.1039/9781788010399

Taline Kazandjian

Kazandjian Taline

ORCID: 0000-0002-5383-0505

https://www.researchgate.net/profile/Taline_Kazandjian

https://twitter.com/TalineKaz

Snake Venom Gland Organoids 10.1016/j.cell.2019.11.038

Venomics of the asp viper Vipera aspis aspis from France 10.1016/j.jprot.2020.103707

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite 10.3389/fphar.2019.00848

Convergent evolution of pain-inducing defensive venom components in spitting cobras 10.1126/science.abb9303

Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib 10.3390/toxins13050302

Irina Vetter

Vetter Irina

ORCID: 0000-0002-3594-9588

Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells 10.1016/j.bcp.2012.02.022

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling 10.1038/emboj.2012.207

Conus Venom Peptide Pharmacology 10.1124/pr.111.005322

Development of High Throughput Calcium Channel Assays to Accelerate the Discovery of Novel Toxins Targeting Human Cav2.2 Channels 10.1016/j.toxicon.2012.04.033

Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels 10.1016/j.bcp.2012.05.008

Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): An atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors 10.1016/j.bcp.2012.06.024

Natural Product Ligands of TRP Channels 10.1007/978-94-007-0265-3_3

Venomics: A new paradigm for natural products-based drug discovery 10.1007/s00726-010-0516-4

α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure 10.1021/ja206408q

Characterization of endogenous calcium responses in neuronal cell lines 10.1016/j.bcp.2009.10.020

Chemical Synthesis and Structure of the Prokineticin Bv8 10.1002/cbic.201000330

Golgi Calcium Pump Secretory Pathway Calcium ATPase 1 (SPCA1) Is a Key Regulator of Insulin-like Growth Factor Receptor (IGF1R) Processing in the Basal-like Breast Cancer Cell Line MDA-MB-231 10.1074/jbc.M110.163329

The Response of Dorsal Root Ganglion Axons to Nerve Growth Factor Gradients Depends on Spinal Level 10.1089/neu.2010.1279

A Bayesian model predicts the response of axons to molecular gradients 10.1073/pnas.0900715106

Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol 10.1016/j.ejpain.2007.07.001

The Effects of pH on Beta-Endorphin and Morphine Inhibition of Calcium Transients in Dorsal Root Ganglion Neurons 10.1016/j.jpain.2006.01.456

The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway 10.1186/1744-8069-2-22

Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom 10.1002/pmic.201500220

α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors 10.1016/j.bcp.2015.01.011

Amplified cold transduction in native nociceptors by M-channel inhibition 10.1523/JNEUROSCI.1473-13.2013

Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2 10.1002/cbin.10508

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom 10.1021/bi5004475

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors 10.1021/jacs.5b00244

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1. 6 in peripheral pain pathways 10.1016/j.pain.2013.05.032

Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives 10.3390/md13042030

ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Cav2. 2 ion channels 10.3390/md10102349

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases 10.1038/nm.3806

Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization 10.1074/jbc.M707865200

MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors 10.1021/bi400882s

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain 10.1038/ncomms4165

Evolution of separate predation-and defence-evoked venoms in carnivorous cone snails 10.1038/ncomms4521

Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus 10.1021/acs.jproteome.5b00630

Imported tropical fish causes ciguatera fish poisoning in Germany 10.1055/s-0040-100439

Subcutaneous ω-Conotoxins Alleviate Mechanical Pain in Rodent Models of Acute Peripheral Neuropathy 10.3390/md19020106

Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors 10.1016/j.bcp.2013.07.016

Therapeutic opportunities for targeting cold pain pathways 10.1016/j.bcp.2014.09.024

Analgesic treatment of ciguatoxin-induced cold allodynia 10.1016/j.pain.2013.06.015

Development and optimization of FLIPR high throughput calcium assays for ion channels and GPCRs 10.1007/978-94-007-2888-2_3

δ-conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails 10.1098/rspb.2015.0817

Multiple actions of f-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins 10.1073/pnas.1214062110

Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia 10.1021/acschemneuro.5b00113

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high‐throughput venom‐based discovery approach 10.1111/bph.13081

Venom Peptides as a Rich Source of Ca(v)2.2 Channel Blockers 10.3390/toxins5020286

2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin 10.1002/chem.201403574

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin 10.1093/neuonc/nou048

Design, synthesis and biological evaluation of two opioid agonist and Cav2. 2 blocker multitarget ligands 10.1111/cbdd.12479

No gain, no pain: Nav1.7 as an analgesic target 10.1021/cn500171p

Differential evolution and neofunctionalization of snake venom metalloprotease domains 10.1074/mcp.M112.023135

Ciguatera fish poisoning: A first epidemic in Germany highlights an increasing risk for European countries 10.1016/j.toxicon.2014.10.016

Axon guidance by growth-rate modulation 10.1073/pnas.0909254107

Expression and Pharmacology of Endogenous Cav Channels in SH-SY5Y Human Neuroblastoma Cells 10.1371/journal.pone.0059293

Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens 10.1124/mol.115.098178

A ray of venom: Combined proteomic and transcriptomic investigation of fish venom composition using barb tissue from the blue-spotted stingray (Neotrygon kuhlii) 10.1016/j.jprot.2014.06.004

Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1 10.1021/cb400012k

Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1. 7-mediated pain 10.3390/toxins8030078

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities 10.1002/anie.201703360

Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay 10.1016/j.bmc.2016.11.007

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus 10.1111/bph.13865

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1 10.1038/srep42810

NaV1. 7 as a pain target–from gene to pharmacology 10.1016/j.pharmthera.2016.11.015

Optimization and In Vivo Profiling of a Refined Rat Model of Walker 256 Breast Cancer Cell-Induced Bone Pain Using Behavioral, Radiological, Histological, Immunohistochemical and Pharmacological Methods 10.3389/fphar.2017.00442

Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy 10.3389/fnmol.2017.00174

Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a 10.1038/srep40883

Synthesis of Multivalent [Lys(8)]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses 10.1071/CH16407

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes 10.1016/j.cub.2017.02.067

The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states 10.1038/srep40127

The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant 10.1371/journal.pone.0173551

Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica 10.1371/journal.pone.0156291

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia 10.1097/j.pain.0000000000000669

Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic sodium channel NaV1. 8 10.1074/jbc.M116.721662

Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay 10.1016/j.bmc.2016.11.007 10.1016/j.bmc.2016.11.007. Epub 2016 Nov 7.

Feeling hot, feeling cold: TRP channels-a great story unfolds 10.1080/23328940.2015.1047721 10.1080/23328940.2015.1047721. eCollection 2015 Apr-Jun.

Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV 1.7 10.1074/jbc.M116.729095

NaV1.7 as a pain target - From gene to pharmacology 10.1016/j.pharmthera.2016.11.015 10.1016/j.pharmthera.2016.11.015.

Neuronal cell lines as model dorsal root ganglion neurons: A transcriptomic comparison 10.1177/1744806916646111

New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives 10.1523/JNEUROSCI.2327-16.2016

Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay 10.1371/journal.pone.0160006

Release of neuropeptides from a neuro-cutaneous co-culture model: A novel in vitro model for studying sensory effects of ciguatoxins 10.1016/j.toxicon.2015.11.004

The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus) 10.3390/toxins8100303

The thermal probe test: A novel behavioral assay to quantify thermal paw withdrawal thresholds in mice 10.1080/23328940.2016.1157668

The Walker 256 Breast Cancer Cell-Induced Bone Pain Model in Rats 10.3389/fphar.2016.00286

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target 10.1177/1744806916665366

Antiallodynic effects of the selective NaV1. 7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen 10.1097/j.pain.0000000000001567

Release of neuropeptides from a neuro-cutaneous co-culture model: A novel in vitro model for studying sensory effects of ciguatoxins 10.1016/j.toxicon.2015.11.004 10.1016/j.toxicon.2015.11.004. Epub 2015 Nov 10.

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi 10.1371/journal.pone.0182848

Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors 10.1016/j.neuropharm.2017.04.008

Pharmacological screening technologies for venom peptide discovery 10.1016/j.neuropharm.2017.03.038

Sodium Channels and Venom Peptide Pharmacology 10.1016/bs.apha.2017.01.004

The pharmacology of voltage-gated sodium channel activators 10.1016/j.neuropharm.2017.04.014

Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology 10.3390/toxins10010015

Ciguatoxin Detection Methods and High-Throughput Assays 10.1002/9781118992685.ch15

Voltage-Gated Sodium Channels as Therapeutic Targets 10.1002/9781118185537.ch3

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain 10.1016/j.molimm.2017.12.016

Toxins in Neurobiology: New tools from old molecules 10.1016/j.neulet.2018.05.008

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species 10.1126/scisignal.aan3398

Role of the NLRP3 inflammasome in a model of acute burn-induced pain 10.1016/j.burns.2016.09.001

An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay 10.1016/j.bmc.2018.05.012

Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels 10.1016/j.lfs.2018.02.030

The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain 10.3389/fphar.2018.00495

A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family 10.1126/sciadv.aau4640

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides 10.1038/s41598-018-31245-4

The E15R point mutation in scorpion toxin Cn2 uncouples its depressant and excitatory activities on human NaV1. 6 10.1021/acs.jmedchem.7b01609

Chemotactic responses of growing neurites to precisely controlled gradients of nerve growth factor 10.1038/sdata.2018.183

Therapeutic potential of cone snail venom peptides (conopeptides) 10.2174/156802612802652457

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity 10.1002/anie.201708927

Transcriptomics in pain research: insights from new and old technologies 10.1039/c8mo00181b

Development of a high-throughput fluorescent no-wash sodium influx assay 10.1371/journal.pone.0213751

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels 10.1016/j.bcp.2019.04.025

Missiles of mass disruption: composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus 10.3390/toxins11110673

Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of NaV1.7 10.3390/biomedicines8020037

Mapping the Molecular Surface of the Analgesic NaV1.7-Selective Peptide Pn3a Reveals Residues Essential for Membrane and Channel Interactions 10.1021/acsptsci.0c00002

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7 10.1074/jbc.RA119.012281

Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe 10.3390/biomedicines8060155

It Takes Two: Dimerization Is Essential for the Broad-Spectrum Predatory and Defensive Activities of the Venom Peptide Mp1a from the Jack Jumper Ant Myrmecia pilosula 10.3390/biomedicines8070185

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor 10.3390/biomedicines8100391

Characterization of three venom peptides from the spitting spider Scytodes thoracica doi:10.1371/journal.pone.0156291

An Integrated Proteomic and Transcriptomic Analysis Reveals the Venom Complexity of the Bullet Ant Paraponera clavata doi: 10.3390/toxins12050324.

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions 10.1021/acsptsci.9b00081

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases doi:10.1038/nm.3806

A Centipede Toxin Family Defines an Ancient Class of CSalphabeta Defensins 10.1016/j.str.2018.10.022

Methods used to evaluate pain behaviors in rodents 10.3389/fnmol.2017.00284

Neurotoxic peptides from the venom of the giant Australian stinging tree 10.1126/sciadv.abb8828.

Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators 10.1073/pnas.2004516117

Seeing the woods for the trees: understanding venom evolution as a guide for biodiscovery 10.1039/9781849737876-00001

Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1. 7 0.1074/jbc.RA119.012281.

Animal toxins—Nature’s evolutionary-refined toolkit for basic research and drug discovery 10.1016/j.bcp.2020.114096

NaV1. 6 regulates excitability of mechanosensitive sensory neurons 10.1113/JP278148

Convergent evolution of pain-inducing defensive venom components in spitting cobras 10.1126/science.abb9303

Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment 10.1093/pm/pnx228

Development of an N-acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain 10.1021/acs.jmedchem.8b01775

Ciguatoxin and ciguatera https://doi.org/10.1007/978-94-007-6419-4_13

Pharmacological activity and NMR solution structure of the leech peptide HSTX-I 10.1016/j.bcp.2020.114082

Recombinant production, bioconjugation and membrane binding studies of Pn3a, a selective NaV1. 7 inhibitor 10.1016/j.bcp.2020.114148

Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell‐induced bone pain 10.1111/1440-1681.13165

How hot is it Down Under? 10.1080/23328940.2016.1218991

Small cyclic sodium channel inhibitors 10.1016/j.bcp.2020.114291

Pharmacology and therapeutic potential of venom peptides 10.1016/j.bcp.2020.114207

Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1. 7 10.1016/j.bcp.2020.114080

Venom peptides as a rich source of cav2. 2 channel blockers doi: 10.3390/toxins5020286.

Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. 10.1084/jem.20201452

Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy 10.3389/fnins.2019.00653

The NLRP3 Inflammasome: Role and Therapeutic Potential in Pain Treatment 10.3389/fphys.2020.01016

Inflammatory and neuropathic gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin, and oxaliplatin in C57BL/6J mice 10.1016/j.jpain.2019.06.008

Enzymatic ligation of a pore blocker toxin and a gating modifier toxin: creating double-knotted peptides with improved sodium channel NaV1. 7 inhibition 10.1021/acs.bioconjchem.9b00744

High-Throughput Fluorescence Assays for Ion Channels and GPCRs 10.1007/978-3-030-12457-1_3

Buzz kill: Function and proteomic composition of venom from the giant assassin fly Dolopus genitalis (Diptera: Asilidae) 10.3390/toxins10110456

Synthesis of Multivalent [Lys8]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses doi.org/10.1071/CH16407

NaV1. 1 and NaV1. 6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome 10.1371/journal.pone.0219106

Characterisation of a novel A-superfamily conotoxin 10.3390/biomedicines8050128

Feeling hot, feeling cold: TRP channels-a great story unfolds 10.1080/23328940.2015.1047721

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling doi:10.1038/emboj.2012.207

Multipurpose peptides: The venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities 10.1016/j.bcp.2021.114693

The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site 10.3390/toxins13080555

Nicholas Casewell

Casewell Nicholas

ORCID: 0000-0002-8035-4719

Firing the sting: chemically induced discharge of cnidae reveals novel proteins and peptides from box jellyfish (Chironex fleckeri) venom. 10.3390/toxins7030936

Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki. 10.1016/j.bbagen.2015.02.002

Venom-related transcripts from Bothrops jararaca tissues provide novel molecular insights into the production and evolution of snake venom. 10.1093/molbev/msu337

VTBuilder: a tool for the assembly of multi isoform transcriptomes. 10.1186/s12859-014-0389-8

Expression of venom gene homologs in diverse python tissues suggests a new model for the evolution of snake venom. 10.1093/molbev/msu294

Extreme venom variation in Middle Eastern vipers: a proteomics comparison of Eristicophis macmahonii, Pseudocerastes fieldi and Pseudocerastes persicus. 10.1016/j.jprot.2014.09.003

Immunological cross-reactivity and neutralisation of European viper venoms with the monospecific Vipera berus antivenom ViperaTAb. 10.3390/toxins6082471

A ray of venom: Combined proteomic and transcriptomic investigation of fish venom composition using barb tissue from the blue-spotted stingray (Neotrygon kuhlii). 10.1016/j.jprot.2014.06.004

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms. 10.1073/pnas.1405484111

Production and assessment of ovine antisera for the manufacture of a veterinary adder antivenom. 10.1136/vr.102286

Snake antivenom trial. 10.1136/vr.g1178

Vintage venoms: proteomic and pharmacological stability of snake venoms stored for up to eight decades. 10.1016/j.jprot.2014.01.004

The Burmese python genome reveals the molecular basis for extreme adaptation in snakes. 10.1073/pnas.1314475110

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system. 10.1073/pnas.1314702110

Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf. 10.1371/journal.pone.0081827

Single-reagent one-step procedures for the purification of ovine IgG, F(ab')2 and Fab antivenoms by caprylic acid. 10.1016/j.jim.2013.11.001

Long-term physicochemical and immunological stability of a liquid formulated intact ovine immunoglobulin-based antivenom. 10.1016/j.toxicon.2012.12.022

Response to "Replies to Fry et al. (Toxicon 2012, 60/4, 434-448). Part B. Analyses of squamate reptile oral glands and their products: A call for caution in formal assignment of terminology designating biological function". 10.1016/j.toxicon.2012.12.023

Differential evolution and neofunctionalization of snake venom metalloprotease domains. 10.1074/mcp.M112.023135

Complex cocktails: the evolutionary novelty of venoms. 10.1016/j.tree.2012.10.020

Response to "Replies to Fry et al. (Toxicon 2012, 60/4, 434-448). Part A. Analyses of squamate reptile oral glands and their products: A call for caution in formal assignment of terminology designating biological function". 10.1016/j.toxicon.2012.11.006

Novel transcripts in the maxillary venom glands of advanced snakes. 10.1016/j.toxicon.2012.03.005

Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise 10.1111/bjh.14591

Venom Evolution: Gene Loss Shapes Phenotypic Adaptation. 10.1016/j.cub.2016.07.082

Visual Pigments, Ocular Filters and the Evolution of Snake Vision. 10.1093/molbev/msw148

Widespread convergence in toxin resistance by predictable molecular evolution. 10.1073/pnas.1511706112

Stabilising the Integrity of Snake Venom mRNA Stored under Tropical Field Conditions Expands Research Horizons. 10.1371/journal.pntd.0004615

On the ancestral recruitment of metalloproteinases into the venom of snakes. 10.1016/j.toxicon.2012.02.006

The structural and functional diversification of the Toxicofera reptile venom system. 10.1016/j.toxicon.2012.02.013

Dynamic evolution of venom proteins in squamate reptiles. 10.1038/ncomms2065

Research strategies to improve snakebite treatment: challenges and progress. 10.1016/j.jprot.2011.06.019

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa. 10.1016/j.jprot.2011.05.027

Domain loss facilitates accelerated evolution and neofunctionalization of duplicate snake venom metalloproteinase toxin genes. 10.1093/molbev/msr091

Gene tree parsimony of multilocus snake venom protein families reveals species tree conflict as a result of multiple parallel gene loss. 10.1093/molbev/msq302

Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom. 10.1371/journal.pntd.0000851

Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts. 10.1186/1471-2164-10-564

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes. 10.1016/j.cub.2017.05.009

Coagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus). 10.3390/toxins9050171

Evolution: Gene Co-option Underpins Venom Protein Evolution. 10.1016/j.cub.2017.05.091

Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies. 10.1016/j.toxlet.2017.08.020

Multipurpose HTS Coagulation Analysis: Assay Development and Assessment of Coagulopathic Snake Venoms 10.3390/toxins9120382

Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis 10.1038/s41598-018-29791-y

Evaluation of the geographical utility of Eastern Russell’s viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity 10.1101/591305

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite 10.1101/717280

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite. 10.3389/fphar.2019.00848

Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation. 10.1021/acs.analchem.9b01261

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals. 10.1016/j.toxicon.2017.10.026

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms. 10.1038/s42003-018-0039-1

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. 10.1016/j.toxicon.2018.04.022

Widespread vulnerability of Malagasy predators to the toxins of an introduced toad. 10.1016/j.cub.2018.04.024

Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins. 10.1016/j.toxicon.2018.06.080

Molecular Adaptations for Sensing and Securing Prey and Insight into Amniote Genome Diversity from the Garter Snake Genome. 10.1093/gbe/evy157

Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms. 10.1007/s00216-018-1253-x

Defining the pathogenic threat of envenoming by South African shield-nosed and coral snakes (genus Aspidelaps), and revealing the likely efficacy of available antivenom. 10.1016/j.jprot.2018.09.019

Community venomics reveals intra-species variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey 10.1101/503276

Friends or Foes? Emerging Impacts of Biological Toxins. 10.1016/j.tibs.2018.12.004

The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims. 10.1093/trstmh/try134

Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey. 10.1016/j.jprot.2019.02.004

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals 10.1073/pnas.1906117116

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging 10.1002/anie.201911390

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging 10.1002/ange.201911390

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics 10.3390/toxins12010053

Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes 10.3390/biomedicines8060165

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity 10.1371/journal.pntd.0008366

Venom Systems as Models for Studying the Origin and Regulation of Evolutionary Novelties 10.1093/molbev/msaa133

Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy 10.3390/toxins12090528

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins 10.3390/biomedicines8090297

An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management 10.1371/journal.pntd.0008579

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms 10.1016/j.apsb.2020.09.005

In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms 10.3390/toxins12120766

Derivation of snake venom gland organoids for in vitro venom production 10.1038/s41596-020-00463-4

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy 10.1371/journal.pntd.0009150

Small Molecule Drug Discovery for Neglected Tropical Snakebite 10.1016/j.tips.2021.02.005

Biogeographic venom variation in Russell’s viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots 10.1371/journal.pntd.0009247

Unexpected lack of specialisation in the flow properties of spitting cobra venom 10.1242/jeb.229229

Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib 10.3390/toxins13050302

Pharmacological Characterisation of Pseudocerastes and Eristicophis Viper Venoms Reveal Anticancer (Melanoma) Properties and a Potentially Novel Mode of Fibrinogenolysis 10.3390/ijms22136896

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming 10.3390/toxins13070451

Convergent evolution of pain-inducing defensive venom components in spitting cobras. 10.1126/science.abb9303

Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms 10.1371/journal.pntd.0009659

Kevin Arbuckle

Arbuckle Kevin

ORCID: 0000-0002-9171-5874

https://swansea.academia.edu/KevinArbuckle

http://www.swansea.ac.uk/staff/science/biosciences/arbucklek/

Evolutionary Context of Venom in Animals 10.1007/978-94-007-6727-0_16-1

Analysing Convergent Evolution: A Practical Guide to Methods 10.1007/978-3-319-41324-2_2

Tempo and Mode of the Evolution of Venom and Poison in Tetrapods 10.3390/toxins8070193

Antipredator defenses predict diversification rates 10.1073/pnas.1509811112

Quantification provides a conceptual basis for convergent evolution 10.1111/brv.12257

Does chemical defence increase niche space? A phylogenetic comparative analysis of the Musteloidea 10.1007/s10682-013-9629-z

A simple measure of the strength of convergent evolution 10.1111/2041-210x.12195

Widespread convergence in toxin resistance by predictable molecular evolution 10.1073/pnas.1511706112

Are mixed diets beneficial for the welfare of captive axolotls (Ambystoma mexicanum)? Effects of feeding regimes on growth and behavior 10.1016/j.jveb.2014.09.004

windex: Analyzing Convergent Evolution Using the Wheatsheaf Index in R 10.4137/ebo.s20968

Patterns of philopatry and longevity contribute to the evolution of post-reproductive lifespan in mammals 10.1098/rsbl.2015.0992

Suitability of day-old chicks as food for captive snakes 10.1111/j.1439-0396.2010.01011.x

Chemical antipredator defence is linked to higher extinction risk 10.1098/rsos.160681

How the Cobra Got Its Flesh-Eating Venom: Cytotoxicity as a Defensive Innovation and Its Co-Evolution with Hooding, Aposematic Marking, and Spitting 10.3390/toxins9030103

Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (Pseudonaja). 10.1016/j.cbpc.2017.04.007

The biology of color 10.1126/science.aan0221

The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom. 10.1007/s12640-017-9771-4

Catch a tiger snake by its tail: differential toxicity, co-factor dependence and antivenom efficacy in a procoagulant clade of Australian venomous snakes. 10.1016/j.cbpc.2017.07.005

Enter the Dragon: The Dynamic and Multifunctional Evolution of Anguimorpha Lizard Venoms 10.3390/toxins9080242

Evolutionary Context of Venom in Animals 10.1007/978-94-007-6458-3_16

Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies. 10.1016/j.toxlet.2017.08.020

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals 10.1016/j.toxicon.2017.10.026

Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis ) 10.1016/j.cbpc.2018.01.001

Factor X activating Atractaspis snake venoms and the relative coagulotoxicity neutralising efficacy of African antivenoms 10.1016/j.toxlet.2018.02.020

A new species of bandy-bandy (Vermicella: Serpentes: Elapidae) from the Weipa region, Cape York, Australia 10.11646/zootaxa.4446.1.1

Harden up: metal acquisition in the weaponized ovipositors of aculeate hymenoptera 10.1007/s00435-018-0403-1

Phylogenetic Comparative Methods can Provide Important Insights into the Evolution of Toxic Weaponry 10.3390/toxins10120518

Coagulotoxic effects by brown snake (Pseudonaja) and taipan (Oxyuranus) venoms, and the efficacy of a new antivenom 10.1016/j.tiv.2019.03.031

The functional convergence of antibiotic resistance in β‐lactamases is not conferred by a simple convergent substitution of amino acid 10.1111/eva.12835

Coevolution of Snake Venom Toxic Activities and Diet: Evidence that Ecological Generalism Favours Toxicological Diversity 10.3390/toxins11120711

Why don’t long-finned pilot whales have a widespread postreproductive lifespan? Insights from genetic data 10.1093/beheco/arz211

Fangs for the Memories? A Survey of Pain in Snakebite Patients Does Not Support a Strong Role for Defense in the Evolution of Snake Venom Composition 10.3390/toxins12030201

From molecules to macroevolution: Venom as a model system for evolutionary biology across levels of life 10.1016/j.toxcx.2020.100034

Convergent evolution of pain-inducing defensive venom components in spitting cobras 10.1126/science.abb9303

Coevolution of group-living and aposematism in caterpillars: warning colouration may facilitate the evolution from group-living to solitary habits 10.1186/s12862-020-01738-w

Special Issue: Evolutionary Ecology of Venom 10.3390/toxins13050310

A double pedigree reveals genetic but not cultural inheritance of cooperative personalities in wild banded mongooses 10.1111/ele.13833

Radiating pain: venom has contributed to the diversification of the largest radiations of vertebrate and invertebrate animals 10.1186/s12862-021-01880-z

Cooperatively breeding banded mongooses do not avoid inbreeding through familiarity-based kin recognition 10.1007/s00265-021-03076-3