Reversion of antibiotic resistance inMycobacterium tuberculosisby spiroisoxazoline SMARt-420
Blondiaux, Nicolas
Moune, Martin
Desroses, Matthieu
Frita, Rosangela
Flipo, Marion
Mathys, Vanessa
Soetaert, Karine
Kiass, Mehdi
Delorme, Vincent
Djaout, Kamel
Trebosc, Vincent
Kemmer, Christian
Wintjens, Rene
Wohlkonig, Alexandre
Antoine, Rudy
Huot, Ludovic
Hot, David
Coscolla, Mireia
Feldmann, Julia
Gagneux, Sebastien
Locht, Camille
Brodin, Priscille
Gitzinger, Marc
Deprez, Benoit
Willand, Nicolas
Baulard, Alain R.
Science (New York, N.Y.), 2017-3
Alexandre Wohlkonig
Wohlkonig Alexandre
/ Wohlkonig
ORCID: 0000-0003-3103-5022
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Kamel Djaout
Djaout Kamel
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Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis
10.1101/555763
Dispersal of Mycobacterium tuberculosis to indigenous populations driven by historical European trade in the South Pacific
10.1101/631937
Multiple merger genealogies in outbreaks of Mycobacterium tuberculosis
10.1101/2019.12.21.885723
Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis
10.1073/pnas.1915551117
Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution?
10.1371/journal.pgen.1008728
Mycobacterium tuberculosis complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to the type strain H37Rv
10.1101/2020.06.22.164186
Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history
10.1099/mgen.0.000477
Case-control, diagnostic accuracy study of a non-sputum CD38-based TAM-TB test from a single milliliter of blood
10.1101/2021.03.10.21253246
Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim [version 2; peer review: 3 approved]
10.12688/f1000research.28318.2
Melting the eis : Nondetection of Kanamycin Resistance Markers by Routine Diagnostic Tests and Identification of New eis Promoter Variants
10.1128/AAC.02502-20
Mycobacterium tuberculosis complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to the type strain H37Rv
10.1099/mgen.0.000437
A new nomenclature for the livestock-associated Mycobacterium tuberculosis complex based on phylogenomics
10.12688/openreseurope.14029.1
Vincent Delorme
Delorme Vincent
ORCID: 0000-0001-5235-7069
Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent.
10.1016/j.bmc.2020.115797
Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages.
10.1016/j.stemcr.2019.10.002
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis.
10.1016/j.bioorg.2018.08.025
Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.
10.3389/fcimb.2018.00114
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Mycobacterium tuberculosis Infection and Innate Responses in a New Model of Lung Alveolar Macrophages.
10.3389/fimmu.2018.00438
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton.
10.15252/embr.201744371
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis.
10.1038/s41598-017-11843-4
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
10.1016/j.celrep.2017.08.101
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.
10.1038/s41598-017-05453-3
Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis.
10.1128/aac.02637-16
Phenotypic assays for Mycobacterium tuberculosis infection.
10.1002/cyto.a.23129
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.
10.1021/acschembio.7b00091
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
10.1126/science.aag1006
High-Content Screening of Raw Actinomycete Extracts for the Identification of Antituberculosis Activities.
10.1177/1087057116675887
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.
10.1111/mmi.13535
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection.
10.1038/srep29297
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.
10.1039/c5ob02630j
Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays.
10.1007/978-1-4939-2450-9_24
2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.
10.1021/cb5007163
Supported inhibitor for fishing lipases in complex biological media and mass spectrometry identification.
10.1016/j.biochi.2014.07.015
A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening.
10.3791/51114
Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones.
10.1016/j.ejmech.2012.10.040
MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth.
10.1371/journal.pone.0046493
Inhibition of phospholipase A1, lipase and galactolipase activities of pancreatic lipase-related protein 2 by methyl arachidonyl fluorophosphonate (MAFP).
10.1016/j.bbalip.2012.07.014
Effects of surfactants on lipase structure, activity, and inhibition.
10.1007/s11095-010-0362-9
CO2 binding by dynamic combinatorial chemistry: an environmental selection.
10.1021/ja909975q
Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function.
10.1096/fj.09-144766
Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases.
10.1021/jm301216x
Phenotypic Screening for Drug Discovery in Tuberculosis
https://doi.org/10.1039/9781839160721-00198
Rosangela Frita
Frita Rosangela
ORCID: 0000-0001-9224-3197
Reversion of antibiotic resistance inMycobacterium tuberculosisby spiroisoxazoline SMARt-420
10.1126/science.aag1006
New active leads for tuberculosis booster drugs by structure-based drug discovery.
10.1039/c7ob00910k
Effects of Lipid-Lowering Drugs on Vancomycin Susceptibility of Mycobacteria.
10.1128/aac.00872-16
The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?
10.1016/j.pt.2013.07.005
In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice.
10.1155/2012/373086
A two-step strategy for the complementation of M. tuberculosis mutants.
10.1590/s1415-47572011000200020
Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing.
10.1186/1475-2875-10-74
Is flow cytometry better in counting malaria pigment-containing leukocytes compared to microscopy?
10.1186/1475-2875-8-255
Construction of targeted mycobacterial mutants by homologous recombination.
10.1007/978-1-59745-207-6_20
The case for hypervirulence through gene deletion in Mycobacterium tuberculosis.
10.1016/j.tim.2008.06.003
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis.
10.1111/j.1365-2958.2007.05827.x
Quantification of global transcription patterns in prokaryotes using spotted microarrays.
10.1186/gb-2007-8-12-r265
What do microarrays really tell us about M. tuberculosis?
10.1016/j.tim.2004.10.005
Camille Locht
Locht Camille
ORCID: 0000-0001-7295-7336
HBHA-Induced Polycytotoxic CD4+ T Lymphocytes Are Associated with the Control of Mycobacterium tuberculosis Infection in Humans
10.4049/jimmunol.1800840
Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS
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Non-specific Effects of Live Attenuated Pertussis Vaccine Against Heterologous Infectious and Inflammatory Diseases
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IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine
10.1038/s41385-018-0073-9
Rv0613c/MSMEG_1285 Interacts with HBHA and Mediates Its Proper Cell-Surface Exposure in Mycobacteria
10.3390/ijms19061673
Tuberculin skin test reaction is related to memory, but not naive CD4+ T cell responses to mycobacterial stimuli in BCG-vaccinated young adults
10.1016/j.vaccine.2018.05.068
Diversion of complement-mediated killing by Bordetella
10.1016/j.micinf.2018.02.002
TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development
10.3389/fimmu.2017.01203
Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis
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Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria
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In vivo imaging of bacterial colonization of the lower respiratory tract in a baboon model of Bordetella pertussis infection and transmission
10.1038/s41598-018-30896-7
Primary transcriptome analysis reveals importance of IS elements for the shaping of the transcriptional landscape of Bordetella pertussis
10.1080/15476286.2018.1462655
Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor
10.1038/s41426-018-0039-8
Construction and evaluation of Bordetella pertussis live attenuated vaccine strain BPZE1 producing Fim3
10.1016/j.vaccine.2018.02.017
Will we have new pertussis vaccines?
10.1016/j.vaccine.2017.11.055
Assessing the reactogenicity of Tdap vaccine administered during pregnancy and antibodies to Bordetella pertussis antigens in maternal and cord sera of Thai women
10.1016/j.vaccine.2018.01.059
Conformational Changes of an Interdomain Linker Mediate Mechanical Signal Transmission in Sensor Kinase BvgS
10.1128/JB.00114-17
Coiled-Coil Antagonism Regulates Activity of Venus Flytrap-Domain-Containing Sensor Kinases of the BvgS Family
10.1128/mBio.02052-17
The Role of Mucosal Immunity in Pertussis
10.3389/fimmu.2018.03068
Live Attenuated Pertussis Vaccine BPZE1 Protects Baboons Against Bordetella pertussis Disease and Infection
10.1093/infdis/jix254
BCG and protection against inflammatory and auto-immune diseases
10.1080/14760584.2017.1333906
Age-Stratified T Cell Responses in Children Infected with Mycobacterium tuberculosis
10.3389/fimmu.2017.01059
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
10.1126/science.aag1006
Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development
10.1128/CVI.00388-16
Erratum for Carbonetti et al., "Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development"
10.1128/CVI.00071-17
Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis
10.15252/emmm.201606330
Live pertussis vaccines: will they protect against carriage and spread of pertussis?
10.1016/j.cmi.2016.05.029
The multifaceted RisA regulon of Bordetella pertussis
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LppM impact on the colonization of macrophages by Mycobacterium tuberculosis
10.1111/cmi.12619
Added Value of Long-Term Cytokine Release Assays to Detect Mycobacterium tuberculosis Infection in HIV-Infected Subjects in Uganda
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[Tuberculosis, a story still relevant]
10.1051/medsci/20163206001
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection
10.1038/srep29297
Pertussis: Where did we go wrong and what can we do about it?
10.1016/j.jinf.2016.04.020
Pertussis: acellular, whole-cell, new vaccines, what to choose?
10.1586/14760584.2016.1161511
Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella
10.1128/mBio.02089-15
Reciprocal interference of maternal and infant immunization in protection against pertussis
10.1016/j.vaccine.2016.01.011
Signal transduction by BvgS sensor kinase. Binding of modulator nicotinate affects the conformation and dynamics of the entire periplasmic moiety
10.1074/jbc.A115.655720
Integrating knowledge of Mycobacterium tuberculosis pathogenesis for the design of better vaccines
10.1586/14760584.2015.1102638
Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults
10.1155/2015/359153
Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
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Dynamic interplay of membrane-proximal POTRA domain and conserved loop L6 in Omp85 transporter FhaC
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Signal Transduction by BvgS Sensor Kinase: BINDING OF MODULATOR NICOTINATE AFFECTS THE CONFORMATION AND DYNAMICS OF THE ENTIRE PERIPLASMIC MOIETY
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Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS
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Investigating pertussis toxin and its impact on vaccination
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Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: comparison with the tuberculin skin test and the QuantiFERON-TB Gold In-tube
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Early cellular immune response to a new candidate mycobacterial vaccine antigen in childhood tuberculosis
10.1016/j.vaccine.2014.12.011
Unconventional, adenosine-producing suppressor T cells induced by dendritic cells exposed to BPZE1 pertussis vaccine
10.1189/jlb.3a0315-101r
Translocation path of a substrate protein through its Omp85 transporter
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Antigen-specific interferon-gamma responses and innate cytokine balance in TB-IRIS
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HBHA vaccination may require both Th1 and Th17 immune responses to protect mice against tuberculosis
10.1016/j.vaccine.2014.09.024
Toward Understanding the Essence of Post-Translational Modifications for the Mycobacterium tuberculosis Immunoproteome
10.3389/fimmu.2014.00361
Live attenuated B. pertussis BPZE1 rescues the immune functions of Respiratory Syncytial virus infected human dendritic cells by promoting Th1/Th17 responses
10.1371/journal.pone.0100166
Live attenuated vaccines against pertussis
10.1586/14760584.2014.942222
Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin
10.1016/j.micinf.2014.04.003
Conformational dynamics of protein transporter FhaC: large-scale motions of plug helix
10.1111/mmi.12585
B-cell responses after intranasal vaccination with the novel attenuated Bordetella pertussis vaccine strain BPZE1 in a randomized phase I clinical trial
10.1016/j.vaccine.2014.04.048
Possible options for new pertussis vaccines
10.1093/infdis/jit531
A phase I clinical study of a live attenuated Bordetella pertussis vaccine--BPZE1; a single centre, double-blind, placebo-controlled, dose-escalating study of BPZE1 given intranasally to healthy adult male volunteers
10.1371/journal.pone.0083449
Mucosal delivery of antigen-coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice
10.1002/eji.201343887
Pertussis toxin improves immune responses to a combined pneumococcal antigen and leads to enhanced protection against Streptococcus pneumoniae
10.1128/CVI.00134-14
Heterologous prime-boost immunization with live attenuated B. pertussis BPZE1 followed by acellular pertussis vaccine in mice
10.1016/j.vaccine.2014.06.019
Key role of effector memory CD4+ T lymphocytes in a short-incubation heparin-binding hemagglutinin gamma interferon release assay for the detection of latent tuberculosis
10.1128/CVI.00651-13
LPS-binding protein and IL-6 mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients
10.1371/journal.pone.0081856
Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism
10.1164/rccm.201307-1227OC
Protective role of adenylate cyclase in the context of a live pertussis vaccine candidate
10.1016/j.micinf.2013.10.002
Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination
10.1016/j.vaccine.2013.10.056
Heparin-binding haemagglutinin, a new tool for the detection of latent Mycobacterium tuberculosis infection in hemodialysis patients
10.1371/journal.pone.0071088
Novel feature of Mycobacterium avium subsp. paratuberculosis, highlighted by characterization of the heparin-binding hemagglutinin adhesin
10.1128/JB.00671-13
Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission
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Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome
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The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome
10.1016/j.imbio.2013.07.004
Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e
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Purification of native HBHA from Mycobacterium avium subsp. paratuberculosis
10.1186/1756-0500-6-55
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis
10.1038/ng.2517
Persistence at one year of age of antigen-induced cellular immune responses in preterm infants vaccinated against whooping cough: comparison of three different vaccines and effect of a booster dose
10.1016/j.vaccine.2013.02.004
Low prevalence of vitamin D deficiency in Ugandan HIV-infected patients with and without tuberculosis
10.5588/ijtld.11.0146
Broad heparin-binding haemagglutinin-specific cytokine and chemokine response in infants following Mycobacterium bovis BCG vaccination
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Risk stratification of latent tuberculosis defined by combined interferon gamma release assays
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Attenuated Bordetella pertussis BPZE1 protects against allergic airway inflammation and contact dermatitis in mouse models
10.1111/j.1398-9995.2012.02884.x
Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice
10.1016/j.vaccine.2012.07.005
New pertussis vaccination approaches: en route to protect newborns?
10.1111/j.1574-695x.2012.00988.x
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis
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Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis
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Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection
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Both CD4⁺ and CD8⁺ lymphocytes participate in the IFN-γ response to filamentous hemagglutinin from Bordetella pertussis in infants, children, and adults
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Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands
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Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors
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The ins and outs of pertussis toxin
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Urinary lipoarabinomannan as predictor for the tuberculosis immune reconstitution inflammatory syndrome
10.1097/qai.0b013e31823801de
Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy
10.1097/qai.0b013e3182255dc2
[New antituberculosis vaccines]
10.1016/j.arcped.2011.05.003
Development of live attenuated Bordetella pertussis strains expressing the universal influenza vaccine candidate M2e
10.1016/j.vaccine.2011.05.052
Recombinant HBHA boosting effect on BCG-induced immunity against Mycobacterium tuberculosis infection
10.1155/2011/730702
Substrate recognition by the POTRA domains of TpsB transporter FhaC
10.1111/j.1365-2958.2011.07680.x
Membrane-associated DegP in Bordetella chaperones a repeat-rich secretory protein
10.1111/j.1365-2958.2011.07672.x
Detection of small RNAs in Bordetella pertussis and identification of a novel repeated genetic element
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The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country
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Attenuated Bordetella pertussis vaccine candidate BPZE1 promotes human dendritic cell CCL21-induced migration and drives a Th1/Th17 response
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Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors
10.1021/jm200076a
Characterization of the Mycobacterium avium subsp. paratuberculosis laminin-binding/histone-like protein (Lbp/Hlp) which reacts with sera from patients with Crohn's disease
10.1016/j.micinf.2011.02.002
Chips from chips: application to the study of antibody responses to methylated proteins
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Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator
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Functional importance of a conserved sequence motif in FhaC, a prototypic member of the TpsB/Omp85 superfamily
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Long-term immunity against pertussis induced by a single nasal administration of live attenuated B. pertussis BPZE1
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Report of the 2nd "French Clinical Vaccinology Meeting Jean-Gerard Guillet": immunization and respiratory diseases
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Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism
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Boosting BCG to protect against TB
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Attenuated Bordetella pertussis protects against highly pathogenic influenza A viruses by dampening the cytokine storm
10.1128/JVI.02542-09
Boosting with mycobacterial heparin-binding haemagglutinin enhances protection of Mycobacterium bovis BCG-vaccinated newborn mice against M. tuberculosis
10.1016/j.vaccine.2010.04.062
T- and B-cell-mediated protection induced by novel, live attenuated pertussis vaccine in mice. Cross protection against parapertussis
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Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model
10.1111/j.1365-2222.2010.03459.x
Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans
10.1164/rccm.201001-0083oc
Impact of HIV infection on the recurrence of tuberculosis in South India
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Dose response of attenuated Bordetella pertussis BPZE1-induced protection in mice
10.1128/CVI.00322-09
Cellular immune responses of preterm infants after vaccination with whole-cell or acellular pertussis vaccines
10.1128/CVI.00328-09
Correction: Molecular Evolution of the Two-Component System BvgAS Involved in Virulence Regulation in Bordetella
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Monocyte-derived interleukin-10 depresses the Bordetella pertussis- specific gamma interferon response in vaccinated infants
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In situ chemical modification of peptide microarrays: application to the study of the antibody responses to methylated antigens
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Molecular evolution of the two-component system BvgAS involved in virulence regulation in Bordetella
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Role of DegP for two-partner secretion in Bordetella
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Cytokine and antibody profiles in 1-year-old children vaccinated with either acellular or whole-cell pertussis vaccine during infancy
10.1016/j.vaccine.2009.07.075
Genomic island excisions in Bordetella petrii
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Subcutaneous boosting with heparin binding haemagglutinin increases BCG-induced protection against tuberculosis
10.1016/j.micinf.2009.07.005
Synthetic EthR inhibitors boost antituberculous activity of ethionamide
10.1038/nm.1950
A live attenuated Bordetella pertussis candidate vaccine does not cause disseminating infection in gamma interferon receptor knockout mice
10.1128/CVI.00082-09
Biomarkers for tuberculosis disease status and diagnosis
10.1097/mcp.0b013e328326f42c
Interaction of the mycobacterial heparin-binding hemagglutinin with actin, as evidenced by single-molecule force spectroscopy
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Origin, spread and demography of the Mycobacterium tuberculosis complex
10.1371/journal.ppat.1000160
Genetic stability of the live attenuated Bordetella pertussis vaccine candidate BPZE1
10.1016/j.vaccine.2008.08.018
The coiled-coil N-terminal domain of the heparin-binding haemagglutinin is required for the humoral and cellular immune responses in mice
10.1016/j.molimm.2008.07.009
Bordetella pertussis filamentous hemagglutinin delivered by mucosal routes enhances immunoglobulin levels in serum and mucosal fluids
10.1111/j.1574-695x.2008.00460.x
A common vaccination strategy to solve unsolved problems of tuberculosis and pertussis?
10.1016/j.micinf.2008.07.008
How a different look at latency can help to develop novel diagnostics and vaccines against tuberculosis
10.1517/14712598.7.11.1665
The peptidyl-prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulins
10.1016/j.jmb.2007.10.088
Highly attenuated Bordetella pertussis strain BPZE1 as a potential live vehicle for delivery of heterologous vaccine candidates
10.1128/IAI.00795-07
Structure-based mechanism of ligand binding for periplasmic solute-binding protein of the Bug family
10.1016/j.jmb.2007.08.006
Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis
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Single-molecule force spectroscopy of mycobacterial adhesin-adhesin interactions
10.1128/JB.01299-07
Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily
10.1126/science.1143860
In vitro expansion of CD4+CD25highFOXP3+CD127low/- regulatory T cells from peripheral blood lymphocytes of healthy Mycobacterium tuberculosis-infected humans
10.1016/j.micinf.2007.06.004
Regulatory T cells depress immune responses to protective antigens in active tuberculosis
10.1164/rccm.200701-084oc
Macrophage-specific Mycobacterium tuberculosis genes: identification by green fluorescent protein and kanamycin resistance selection
10.1099/mic.0.2006/000547-0
Enzymatic methylation of the Mycobacterium tuberculosis heparin-binding haemagglutinin
10.1111/j.1574-6968.2007.00636.x
Crystal structures of two Bordetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamily
10.1016/j.jmb.2007.04.047
IL-18 does not increase allergic airway disease in mice when produced by BCG
10.1155/2007/67276
Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis
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Mycobacterium smegmatis produces an HBHA homologue which is not involved in epithelial adherence
10.1016/j.micinf.2006.11.007
Combined RNAseq and ChIPseq Analyses of the BvgA Virulence Regulator of Bordetella pertussis
10.1128/mSystems.00208-20
Good old BCG – what a century‐old vaccine can contribute to modern medicine
10.1111/joim.13195
The History of Pertussis Toxin
10.3390/toxins13090623
Priscille Brodin
Brodin Priscille
ORCID: 0000-0003-0991-7344
Email: priscille.brodin@inserm.fr
How can nanoparticles contribute to antituberculosis therapy?
10.1016/j.drudis.2017.01.011
Host-directed therapies offer novel opportunities for the fight against tuberculosis
10.1016/j.drudis.2017.05.005
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone
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Mycolactone The amazing analgesic mycobacterial toxin
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Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo
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High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis
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Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system
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Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro
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Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action
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Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays
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Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways
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Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro
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A novel specific edge effect correction method for RNA interference screenings
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Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis
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Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors
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The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence
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Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis
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Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors
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High-content screening in infectious diseases
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Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ
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High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling
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High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery
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Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting
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Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure
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Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
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High Content Screening Identifies Decaprenyl-Phosphoribose 2 ' Epimerase as a Target for Intracellular Antimycobacterial Inhibitors
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Systematic Genetic Nomenclature for Type VII Secretion Systems
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Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP
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Aquatic insects and transmission of Mycobacterium ulcerans
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ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity
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Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis
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Protection against mycobacterium ulcerans lesion development by exposure to aquatic insect saliva
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Support vector machines for automatic detection of tuberculosis bacteria in confocal microscopy images
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Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues
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An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis
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Benzofuro 3,2-f 1 benzopyrans: A new class of antitubercular agents
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Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence
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High frequency of CD4(+) T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection
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Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence
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Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis
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Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity
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Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics
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Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions
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Tuberculosis: from genome to vaccine
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Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6
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Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens
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ESAT-6 proteins: protective antigens and virulence factors?
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Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex
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CD8(+)-T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family
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Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
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A new evolutionary scenario for the Mycobacterium tuberculosis complex
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Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant
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Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides
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Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
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6-Oxocytidine containing oligonucleotides inhibit the HIV-1 integrase in vitro
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Inhibition of the human immunodeficiency virus type 1 DNA integration by modified oligonucleotides
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Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides
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A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
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Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids
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ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton
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Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles
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Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis
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Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays
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Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages
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Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling
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Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids
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Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry
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Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors
10.1016/j.celrep.2018.03.125
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis
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Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation
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Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis
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The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase
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Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis
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Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs
10.1016/j.ijpharm.2017.05.030
Host-pathogen systems for early drug discovery against tuberculosis
10.1016/j.mib.2017.11.017
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages
10.1016/j.chom.2017.07.020
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling
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Phenotypic assays for Mycobacterium tuberculosis infection
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A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening
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Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections
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Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation
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Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters
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Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis
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Mitochondrial Dynamics and Activity in Legionella-Infected Cells
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Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria
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Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication
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A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation
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Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls
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Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies.
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Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity.
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Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds.
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Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis.
10.1016/j.vaccine.2019.11.085
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection
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Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture.
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Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro.
10.3389/fmicb.2015.00488
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.
10.1038/nm.3262
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
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Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease.
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Automated HTS/HCS for antivirals using visual HIV full replication assays.
10.1186/1742-4690-6-s2-p82
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system.
10.4049/jimmunol.174.6.3570
Cell microbiology interview
10.1111/cmi.13288
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts
10.1099/mgen.0.000505
Vincent Trebosc
Trebosc Vincent
ORCID: 0000-0002-8961-1371
Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects
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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
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A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism
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Engineering of a Synthetic Metabolic Pathway for the Assimilation of (D)-Xylose into Value-Added Chemicals
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In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms
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A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii.
10.1038/s41564-020-0737-6
Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates.
10.1128/mbio.01083-19
Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains.
10.1016/j.ebiom.2019.02.061
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nicolas willand
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Neuraminidase inhibitors and risk of H5 N1 influenza,Les inhibiteurs de neuraminidase face au risque de grippe aviaire
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Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands
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Water-based conditions for the microscale parallel synthesis of bicyclic lactams
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Exploring drug target flexibility using in situ click chemistry: Application to a mycobacterial transcriptional regulator
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Synthesis of N-(iodophenyl)-amides via an unprecedented Ullmann-Finkelstein tandem reaction
10.1016/j.tetlet.2005.12.022
Synthesis of functionalized 2-isoxazolines as three-dimensional fragments for fragment-based drug discovery
10.1016/j.tetlet.2015.05.035
Efficient, two-step synthesis of N-substituted nortropinone derivatives
10.1016/j.tetlet.2007.05.110
Natural compounds: Leads or ideas? Bioinspired molecules for drug discovery
10.1111/j.1747-0285.2008.00673.x
MALDI imaging techniques dedicated to drug-distribution studies
10.4155/bio.11.88
Solid and solution phase syntheses of the 2-cyanopyrrolidide DPP-IV inhibitor NVP-DPP728
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Original loading and Suzuki conditions for the solid-phase synthesis of biphenyltetrazoles. Application to the first solid-phase synthesis of irbesartan
10.1016/j.tetlet.2008.02.147
Application of Ullmann and Ullmann-Finkelstein reactions for the synthesis of N-aryl-N-(1H-pyrazol-3-yl) acetamide or N-(1-aryl-1H-pyrazol-3-yl) acetamide derivatives and pharmacological evaluation
10.1016/j.ejmech.2011.05.056
A simple reaction to produce small structurally complex and diverse molecules
10.1016/j.tetlet.2004.05.008
Efficient, protection-free Suzuki-Miyaura synthesis of ortho- biphenyltetrazoles
10.1016/j.tetlet.2005.07.082
Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands
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Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space
10.1016/j.tetlet.2016.05.065
Ethionamide boosters: Synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors
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Carbohydrate-protein interactions at interfaces: Synthesis of thiolactosyl glycolipids and design of a working model for surface plasmon resonance
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Structural and docking studies of potent ethionamide boosters
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A versatile solid-phase synthesis of 3-aryl-1,2,4-oxadiazolones and analogues
10.1016/j.tetlet.2006.12.050
UFU ('Ullmann-Finkelstein-Ullmann'): a new multicomponent reaction
10.1016/j.tetlet.2006.04.041
Palladium-free Sonogashira-type cross-coupling reaction of bromoisoxazolines or N-alkoxyimidoyl bromides and alkynes
10.1016/j.tetlet.2016.01.070
Tuberculosis: The drug development pipeline at a glance
10.1016/j.ejmech.2012.02.033
Synthesis and structural studies of a novel scaffold for drug discovery: A 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4′-piperidine]
10.1016/j.tetlet.2003.11.079
Synthetic EthR inhibitors boost antituberculous activity of ethionamide
10.1038/nm.1950
A facile and rapid synthesis of N-benzyl-2-substituted piperazines
10.1016/j.tetlet.2011.02.011
Ligand efficiency driven design of new inhibitors of mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches
10.1021/jm500422b
Discovery of novel N -phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis
10.1021/jm300377g
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors
10.1021/jm200825u
A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR
10.1016/j.bbapap.2018.12.003
A novel codrug made of the combination of ethionamide and its potentiating booster: Synthesis, self-assembly into nanoparticles and antimycobacterial evaluation
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Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2
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Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance
10.1016/bs.armc.2019.06.003
New active leads for tuberculosis booster drugs by structure-based drug discovery
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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
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Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis
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Intrinsic antibacterial activity of nanoparticles made of β-cyclodextrins potentiates their effect as drug nanocarriers against tuberculosis
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Combination therapy for tuberculosis treatment: Pulmonary administration of ethionamide and booster co-loaded nanoparticles
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Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity
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Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening
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Microwave-Assisted Suzuki-Miyaura Cross Coupling using Nickel as Catalyst to Rapidly Access to 3-Arylazetidine
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Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs
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A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2
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Nathalie deboosere
deboosere Nathalie
ORCID: 0000-0002-2873-5485
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton.
10.15252/embr.201744371
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
10.1016/j.celrep.2017.08.101
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone.
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Phenotypic assays for Mycobacterium tuberculosis infection.
10.1002/cyto.a.23129
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.
10.1021/acschembio.7b00091
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection.
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LppM impact on the colonization of macrophages by Mycobacterium tuberculosis.
10.1111/cmi.12619
A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening.
10.3791/51114
Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces.
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Viral elution and concentration method for detection of influenza A viruses in mud by real-time RT-PCR.
10.1016/j.jviromet.2011.10.013
Comparison of chlorine and peroxyacetic-based disinfectant to inactivate Feline calicivirus, Murine norovirus and Hepatitis A virus on lettuce.
10.1016/j.ijfoodmicro.2011.08.011
Direct detection of highly pathogenic avian influenza A/H5N1 virus from mud specimens.
10.1016/j.jviromet.2011.06.002
Development and validation of a concentration method for the detection of influenza a viruses from large volumes of surface water.
10.1128/aem.02484-10
A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries.
10.1016/j.fm.2010.05.018
Assessment of the removal and inactivation of influenza viruses H5N1 and H1N1 by drinking water treatment.
10.1016/j.watres.2010.01.013
Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables.
10.1016/j.ijfoodmicro.2005.11.007
Modelling effect of physical and chemical parameters on heat inactivation kinetics of hepatitis A virus in a fruit model system.
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Host-pathogen systems for early drug discovery against tuberculosis.
10.1016/j.mib.2017.11.017
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids.
10.1073/pnas.1707840114
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis.
10.1038/s41598-017-11843-4
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages.
10.1016/j.chom.2017.07.020
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.
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Host-directed therapies offer novel opportunities for the fight against tuberculosis.
10.1016/j.drudis.2017.05.005
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs.
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Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis.
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Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections.
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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
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Mireia Coscolla
Coscolla Mireia
ORCID: 0000-0003-0752-0538
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Consequences of genomic diversity in Mycobacterium tuberculosis
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KvarQ: targeted and direct variant calling from fastq reads of bacterial genomes
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Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis
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A New Method for Extracting Skin Microbes Allows Metagenomic Analysis of Whole-Deep Skin
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Does M. tuberculosis genomic diversity explain disease diversity?
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Tuberculosis outbreak investigation using phylodynamic analysis.
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Tuberculosis in Swiss captive Asian elephants: microevolution of Mycobacterium tuberculosis characterized by multilocus variable-number tandem-repeat analysis and whole-genome sequencing.
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Primary transcriptome analysis reveals importance of IS elements for the shaping of the transcriptional landscape of Bordetella pertussis.
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Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis.
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Assessment of Common and Emerging Bioinformatics Pipelines for Targeted Metagenomics.
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ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.
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Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2.
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Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
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Rudy Antoine
Antoine Rudy
ORCID: 0000-0002-7369-0626
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Detection of small RNAs in Bordetella pertussis and identification of a novel repeated genetic element.
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