Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication
Heather Hulme Lynsey M. Meikle Nicole Strittmatter Justin J. J. van der Hooft John Swales Ryan A. Bragg Victor H. Villar Michael J. Ormsby Stephanie Barnes Sheila L. Brown Alex Dexter Maya T. Kamat Jasper C. Komen Daniel Walker Simon Milling Emily K. Osterweil Andrew S. MacDonald Chris J. Schofield Saverio Tardito Josephine Bunch Gillian Douce Julia M. Edgar RuAngelie Edrada-Ebel Richard J. A. Goodwin Richard Burchmore Daniel M. Wall
VICTOR H. VILLAR
VILLAR VICTOR H. / Villar VH / Villar VH
ORCID: 0000-0003-2837-5018
Oleanolic and maslinic acid Sensitize soft tissue sarcoma Cells to Doxorubicin by inhibiting the multidrug resistance protein mrp-1, but not p-glycoprotein 10.1016/j.jnutbio.2013.12.003
Glutaminolysis and autophagy in cancer 10.1080/15548627.2015.1053680
mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. 10.1038/ncomms14124
Glutamoptosis: A new cell death mechanism inhibited by autophagy during nutritional imbalance. 10.1080/15548627.2017.1299315
Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR 10.1080/23723556.2017.1297284
Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma 10.1371/journal.pone.0155946
Down-regulation of the AKT/GSK3β/β-catenin signalling pathway by the triterpene ursolic acid induced intrinsic apoptosis in human soft tissue sarcomas 10.1016/j.chemphyslip.2010.05.083
Nilotinib as Coadjuvant Treatment with Doxorubicin in Patients with Sarcomas: A Phase I Trial of the Spanish Group for Research on Sarcoma 10.1158/1078-0432.CCR-18-0851
Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas 10.1371/journal.pone.0037735
ROS-NFκΒ mediates TGF-β1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion 10.1007/s11010-010-0418-5
SKIP is required for TGF-β1-induced epithelial mesenchymal transition and migration in transformed keratinocytes 10.1016/j.febslet.2010.10.020
Spred2 inhibits TGF-β1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition 10.1002/ijc.25045
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication 10.1126/sciadv.aax6328
Skip Regulates TGF-β1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells 10.1155/2013/398253
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis 10.1038/s41467-021-25079-4
The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? 10.1155/2021/5523055
Maya Kamat
Kamat Maya
ORCID: 0000-0002-7792-2084
Rapid in-country sequencing of whole virus genomes to inform rabies elimination programmes [version 1; peer review: 3 approved] 10.12688/wellcomeopenres.15518.1
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication 10.1126/sciadv.aax6328
Michael Ormsby
Ormsby Michael
ORCID: 0000-0002-3991-2336
Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori 10.1038/s41417-018-0039-9
Correction: Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori 10.1038/s41417-018-0047-9
Author Correction: Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori 10.1038/s41417-019-0086-x
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication 10.1126/sciadv.aax6328
Justin van der Hooft
van der Hooft Justin / Justin J.J. van der Hooft
ORCID: 0000-0002-9340-5511
Structural elucidation of low abundant metabolites in complex sample matrices 10.1007/s11306-013-0519-8
Non-smoky GLYCOSYLTRANSFERASE1 prevents the release of smoky aroma from tomato fruit 10.1105/tpc.113.114231
Automatic chemical structure annotation of an LC-MSn based metabolic profile from green tea 10.1021/ac400861a
Substructure-based annotation of high-resolution multistage MSn spectral trees 10.1002/rcm.6364
Structural annotation and elucidation of conjugated phenolic compounds in black, green, and white tea extracts 10.1021/jf300297y
Structural elucidation and quantification of phenolic conjugates present in human urine after tea intake 10.1021/ac3017339
Spectral trees as a robust annotation tool in LC-MS based metabolomics 10.1007/s11306-011-0363-7
Metabolite identification using automated comparison of high-resolution multistage mass spectral trees 10.1021/ac2034216
Inhibitory activity of plumbagin produced by Drosera intermedia on food spoilage fungi 10.1002/jsfa.5522
A strategy for fast structural elucidation of metabolites in small volume plant extracts using automated MS-guided LC-MS-SPE-NMR 10.1002/mrc.2833
Thermal diffusivity of periderm from tomatoes of different maturity stages as determined by the concept of the frequency-domain open photoacoustic cell 10.1063/1.3530735
Polyphenol identification based on systematic and robust high-resolution accurate mass spectrometry fragmentation 10.1021/ac102546x
Iridoid and caffeoyl phenylethanoid glycosides of the endangered carnivorous plant Pinguicula lusitanica L. (Lentibulariaceae) 10.1016/j.bse.2009.05.003
Topic modeling for untargeted substructure exploration in metabolomics 10.1073/pnas.1608041113
Propagating annotations of molecular networks using in silico fragmentation 10.1371/journal.pcbi.1006089
Did a plant-herbivore arms race drive chemical diversity in Euphorbia? 10.1101/323014
Automatic Compound Annotation from Mass Spectrometry Data Using MAGMa. 10.5702/massspectrometry.S0033
Interactions of blacktea polyphenols with human gut microbiota: implications for gut and cardiovascular health 10.3945/ajcn.113.058263
Identification of a drimenol synthase and drimenol oxidase from Persicaria hydropiper, involved in the biosynthesis of insect deterrent drimanes 10.1111/tpj.13527
Enhanced Acylcarnitine Annotation in High-Resolution Mass Spectrometry Data: Fragmentation Analysis for the Classification and Annotation of Acylcarnitines 10.3389/fbioe.2015.00026
Rapid and sustained systemic circulation of conjugated gut microbiol catabolites after single-dose black tea extract consumption 10.1021/pr5001253
In Silico Prediction and Automatic LC–MSn Annotation of Green Tea Metabolites in Urine 10.1021/ac403875b
Unexpected differential metabolic responses of Campylobacter jejuni to the abundant presence of glutamate and fucose 10.1007/s11306-018-1438-5
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1101/463620
Deciphering complex metabolite mixtures by unsupervised and supervised substructure discovery and semi-automated annotation from MS/MS spectra 10.1101/491506
Accelerating metabolite identification in natural product research: toward an ideal combination of LC-HRMS/MS and NMR profiling, in silico databases and chemometrics 10.1021/acs.analchem.8b05112
Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages 10.1101/347716
Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings https://doi.org/10.1016/j.mam.2017.11.002
Metabolite Identification in Complex Mixtures Using Nuclear Magnetic Resonance Spectroscopy 10.1007/978-3-319-28275-6_6-2
Ms2lda.org: web-based topic modelling for substructure discovery in mass spectrometry 10.1093/bioinformatics/btx582
A comprehensive evaluation of the [2-14C](–)-epicatechin metabolome in rats https://doi.org/10.1016/j.freeradbiomed.2016.08.001
The food metabolome: a window over dietary exposure 10.3945/ajcn.113.076133
Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols 10.3945/ajcn.113.058958
Unsupervised Discovery and Comparison of Structural Families Across Multiple Samples in Untargeted Metabolomics 10.1021/acs.analchem.7b01391
A community-driven paired data platform to accelerate natural product mining by combining structural information from genomes and metabolomes 10.18174/FAIRdata2018.16286
Implementations of the chemical structural and compositional similarity metric in R and Python 10.1101/546150
Comprehensive mass spectrometry-guided phenotyping of plant specialized metabolites reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1111/tpj.14292
A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters 10.1186/s13104-019-4222-3
The Metabolomics Society—Current State of the Membership and Future Directions 10.3390/metabo9050089
Deciphering complex metabolite mixtures by unsupervised and supervised substructure discovery and semi-automated annotation from MS/MS spectra 10.1039/C8FD00235E
MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools 10.1101/654459
Substantial extracellular metabolic differences found between phylogenetically closely related probiotic and pathogenic strains of Escherichia coli 10.3389/fmicb.2019.00252
Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia l. 10.3389/fpls.2019.00846
Molnetenhancer: Enhanced molecular networks by integrating metabolome mining and annotation tools 10.3390/metabo9070144
In Silico Optimization of Mass Spectrometry Fragmentation Strategies in Metabolomics 10.3390/metabo9100219
MIBiG 2.0: a repository for biosynthetic gene clusters of known function 10.1093/nar/gkz882
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery 10.1021/acscentsci.9b00806
Mass spectrometry searches using MASST 10.1038/s41587-019-0375-9
Assessing specialized metabolite diversity of Alnus species by a digitized LC–MS/MS data analysis workflow 10.1016/j.phytochem.2020.112292
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication 10.1126/sciadv.aax6328
Chemically-informed Analyses of Metabolomics Mass Spectrometry Data with Qemistree 10.1101/2020.05.04.077636
Linking genomics and metabolomics to chart specialized metabolic diversity 10.1039/D0CS00162G
Reproducible molecular networking of untargeted mass spectrometry data using GNPS 10.1038/s41596-020-0317-5
Decomposing metabolite set activity levels with PALS 10.1101/2020.06.07.138974
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions 10.1101/2020.06.12.148205
Phenylpropane as an Alternative Dearomatizing Unit of Indoles: Discovery of Inaequalisines A and B Using Substructure-Informed Molecular Networking 10.1021/acs.orglett.0c02153
matchms - processing and similarity evaluation of mass spectrometry data 10.1101/2020.08.06.239244
Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships 10.1101/2020.08.11.245928
BiG-SLiCE: A Highly Scalable Tool Maps the Diversity of 1.2 Million Biosynthetic Gene Clusters 10.1101/2020.08.17.240838
matchms - processing and similarity evaluation of mass spectrometry data. 10.21105/joss.02411
ReDU: a framework to find and reanalyze public mass spectrometry data 10.1038/s41592-020-0916-7
Feature-based molecular networking in the GNPS analysis environment 10.1038/s41592-020-0933-6
Rapid Development of Improved Data-dependent Acquisition Strategies 10.1101/2020.09.11.293092
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree 10.1038/s41589-020-00677-3
Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data 10.1038/s41587-020-0700-3
The ant fungus garden acts as an external digestive system 10.1101/2020.11.18.389361
BiG-MAP: an automated pipeline to profile metabolic gene cluster abundance and expression in microbiomes 10.1101/2020.12.14.422671
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters 10.1093/gigascience/giaa154
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs 10.1371/journal.ppat.1008932
Comparative Metabologenomics Analysis of Polar Actinomycetes 10.3390/md19020103
Ranking Metabolite Sets by Their Activity Levels 10.3390/metabo11020103
Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships 10.1371/journal.pcbi.1008724
Rapid Development of Improved Data-Dependent Acquisition Strategies 10.1021/acs.analchem.0c03895
MS2DeepScore - a novel deep learning similarity measure for mass fragmentation spectrum comparisons 10.1101/2021.04.18.440324
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions 10.1371/journal.pcbi.1008920
Metabolomics-Guided Elucidation of Plant Abiotic Stress Responses in the 4IR Era: An Overview 10.3390/metabo11070445
Chemical Gradients of Plant Substrates in an Atta texana Fungus Garden 10.1128/mSystems.00601-21
Comprehensive Large-Scale Integrative Analysis of Omics Data To Accelerate Specialized Metabolite Discovery 10.1128/mSystems.00726-21
Nicole Strittmatter
Strittmatter Nicole
ORCID: 0000-0003-1277-9608
Analysis of intact bacteria using rapid evaporative ionisation mass spectrometry 10.1039/c3cc42015a
Characterization and Identification of Clinically Relevant Microorganisms Using Rapid Evaporative Ionization Mass Spectrometry 10.1021/ac501075f
Mass Spectrometry Imaging of Cassette-Dosed Drugs for Higher Throughput Pharmacokinetic and Biodistribution Analysis 10.1021/ac502217r
Chemo-informatic strategy for imaging mass spectrometry-based hyperspectral profiling of lipid signatures in colorectal cancer 10.1073/pnas.1310524111
Discrimination of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging 10.1039/c3cc48927b
Unique metabolites protect earthworms against plant polyphenols 10.1038/ncomms8869
Network analysis of mass spectrometry imaging data from colorectal cancer identifies key metabolites common to metastatic development 10.1101/230052
Rapid Evaporative Ionization Mass Spectrometry Imaging Platform for Direct Mapping from Bulk Tissue and Bacterial Growth Media 10.1021/ac5046752
Repeatability and reproducibility of desorption electrospray ionization-mass spectrometry (DESI-MS) for the imaging analysis of human cancer tissue: a gateway for clinical applications 10.1039/c4ay01770f
Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry 10.1186/s13742-015-0059-4
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo 10.1126/scitranslmed.aad2355
Shotgun Lipidomic Profiling of the NCI60 Cell Line Panel Using Rapid Evaporative Ionization Mass Spectrometry 10.1021/acs.analchem.6b00187
Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry 10.1016/j.neuroimage.2016.05.004
Imaging of Esophageal Lymph Node Metastases by Desorption Electrospray Ionization Mass Spectrometry 10.1158/0008-5472.can-16-0699
Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging 10.1038/srep39219
Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers 10.1016/j.jconrel.2016.12.034
Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection 10.1038/s41598-017-03100-5
Translational utility of a hierarchical classification strategy in biomolecular data analytics 10.1038/s41598-017-14092-7
Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging 10.1021/acs.analchem.7b05239
A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability 10.1016/j.neuroimage.2018.01.013
Uncovering the regional localization of inhaled salmeterol retention in the lung 10.1080/10717544.2018.1455762
Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice 10.3389/fmolb.2018.00028
Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging 10.1007/s11306-019-1531-4
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication 10.1126/sciadv.aax6328
High-resolution 3D visualization of nanomedicine distribution in tumors 10.7150/thno.37178
Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging 10.1089/jamp.2019.1536
De novo lipogenesis alters the phospholipidome of esophageal adenocarcinoma 10.1158/0008-5472.can-19-4035
Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry 10.1158/0008-5472.can-14-2258
Analysis of wastewater samples by direct combination of thin-film microextraction and desorption electrospray ionization mass spectrometry 10.1039/c2an35411j
Universal Sample Preparation Unlocking Multimodal Molecular Tissue Imaging 10.1021/acs.analchem.0c00826
Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds 10.1021/jasms.0c00166
Ambient Mass Spectrometry in Cancer Research 10.1016/bs.acr.2016.11.011
Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging 10.1038/srep37648
Correction to: Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging (Metabolomics, (2019), 15, 5, (68), 10.1007/s11306-019-1531-4) 10.1007/s11306-019-1540-3
Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs 10.1158/1078-0432.ccr-19-1871
Evaluation of UV-C Decontamination of Clinical Tissue Sections for Spatially Resolved Analysis by Mass Spectrometry Imaging (MSI) 10.1021/acs.analchem.0c03430
Deep Learning-Based Annotation Transfer between Molecular Imaging Modalities: An Automated Workflow for Multimodal Data Integration 10.1021/acs.analchem.0c02726
Method to Investigate the Distribution of Water-Soluble Drug-Delivery Systems in Fresh Frozen Tissues Using Imaging Mass Cytometry 10.1021/acs.analchem.0c03908
Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging 10.1038/s41596-021-00538-w
Saverio Tardito
Tardito Saverio
ORCID: 0000-0002-5294-8683
Synthesis, solution equilibria and antiproliferative activity of copper(II) aminomethyltriazole and aminomethylthioxotriazoline complexes. 10.1016/j.jinorgbio.2005.04.017
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. 10.1016/j.ccell.2014.12.002
Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts. 10.1038/bjc.2014.425
Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification. 10.1016/j.stem.2014.06.002
Polyphenon E(R), a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis. 10.1093/carcin/bgt481
Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation. 10.1021/jm301053a
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids. 10.1038/onc.2012.465
Glutamine stimulates mTORC1 independent of the cell content of essential amino acids. 10.1007/s00726-012-1312-0
Expanding targets for a metabolic therapy of cancer: L-asparaginase. 10.2174/157489212798358001
L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of β-catenin-mutated human hepatocellular carcinoma cells. 10.2174/156800911797264725
The non-proteinogenic amino acids L-methionine sulfoximine and DL-phosphinothricin activate mTOR. 10.1007/s00726-011-0981-4
Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells. 10.1021/ja109413c
Platelet gel in the treatment of cutaneous ulcers: the experience of the Immunohaematology and Transfusion Centre of Parma. 10.2450/2009.0118-09
The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. 10.1074/jbc.M109.026583
TOE1 interacts with p53 to modulate its transactivation potential. 10.1016/j.febslet.2009.06.004
Synthesis, structural characterisation and solution chemistry of ruthenium(III) triazole-thiadiazine complexes. 10.1039/b823271g
Copper compounds in anticancer strategies. 10.2174/092986709787846532
Thioamido coordination in a thioxo-1,2,4-triazole copper(II) complex enhances nonapoptotic programmed cell death associated with copper accumulation and oxidative stress in human cancer cells. 10.1021/jm061174f
The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase. 10.1007/s00280-007-0421-z
Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. 10.1007/s00418-006-0183-4
Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways. 10.15252/emmm.201707729
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells. 10.1038/nm.4399
Cancer metabolism at a glance. 10.1242/jcs.181016
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. 10.1038/ncb3272
Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth 10.3390/ijms19041099
Improving the metabolic fidelity of cancer models with a physiological cell culture medium 10.1126/sciadv.aau7314
Cell Culture Medium Formulation and Its Implications in Cancer Metabolism 10.1016/j.trecan.2019.05.004
Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells 10.1038/s42255-019-0084-1
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication 10.1126/sciadv.aax6328
Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer 10.1158/0008-5472.can-19-1684
A map of the altered glioma metabolism 10.1016/j.molmed.2021.07.011
Julia Edgar
Edgar Julia
ORCID: 0000-0002-3869-0962
A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination 10.1038/nn.4425
An in vitro model for studying CNS white matter: functional properties and experimental approaches [version 1; referees: 2 approved] 10.12688/f1000research.16802.1
The Axon-Myelin Unit in Development and Degenerative Disease 10.3389/fnins.2018.00467
Reduced axonal diameter of peripheral nerve fibers in a mouse model of Rett syndrome 10.1016/j.neuroscience.2017.06.061
Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected 10.1186/s40478-017-0450-8
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain 10.1038/ncomms14241
Time-Lapse Imaging of Glial-Axonal Interactions 10.1002/0471142301.ns0223s72
Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9 10.1093/brain/awv102
In vivo labeling of peroxisomes by photoconvertible mEos2 in myelinating glia of mice 10.1016/j.biochi.2013.10.022
Progesterone Antagonist Therapy in a Pelizaeus-Merzbacher Mouse Model 10.1016/j.ajhg.2014.03.001
Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2 10.1002/glia.22561
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity 10.1038/nature11007
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue 10.1016/j.cell.2013.11.044
Interactions among mitochondrial proteins altered in glioblastoma 10.1007/s11060-014-1430-5
Neuronal Expression of GalNAc Transferase Is Sufficient to Prevent the Age-Related Neurodegenerative Phenotype of Complex Ganglioside-Deficient Mice 10.1523/jneurosci.3996-13.2014
Time-Lapse Imaging of the Dynamics of CNS Glial-Axonal Interactions In Vitro and Ex Vivo 10.1371/journal.pone.0030775
High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology 10.1002/nbm.1700
Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease 10.1111/j.1469-7580.2011.01363.x
PLP/DM20 Expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease 10.1002/glia.21043
Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus‐Merzbacher disease 10.1002/emmm.200900057
The role of CNS glia in preserving axon function 10.1016/j.conb.2009.08.003
Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression ofCnp1 10.1002/glia.20893
Distribution of mitochondria along small‐diameter myelinated central nervous system axons 10.1002/jnr.21672
PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. 10.1002/glia.20465
Murine spinal cord explants: a model for evaluating axonal growth and myelination in vitro. 10.1002/jnr.21084
Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. 10.1007/s11064-006-9122-y
Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. 10.1002/jnr.20859
Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. 10.1002/glia.20325
Characterization of the murine splice variant Mobp155: developmental CNS expression pattern and subcellular localization of epitope-tagged protein. 10.1002/glia.20155
Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. 10.1083/jcb.200312012
The myelinated axon is dependent on the myelinating cell for support and maintenance: molecules involved. 10.1002/jnr.20063
Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. 10.1007/s00401-003-0808-9
Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. 10.1002/glia.10103
Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. 10.1083/jcb.200202124
The proteolipid protein gene and myelin disorders in man and animal models. 10.1093/hmg/9.6.987
The fates of cells generated at the end of neurogenesis in developing mouse cortex. 10.1002/neu.1056
Radial migration in the cerebral cortex is enhanced by signals from thalamus. 10.1046/j.0953-816x.2001.01554.x
Transmission Electron Microscopy and Morphometry of the CNS White Matter 10.1007/978-1-0716-0585-1_18
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication 10.1126/sciadv.aax6328
Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease 10.1093/brain/awaa080