Paperbase

Graham W Knott

Knott Graham W

ORCID: 0000-0002-2956-9052

http://bioem.epfl.ch

http://neuromorph.epfl.ch

Improving 3D em data segmentation by joint optimization over boundary evidence and biological priors 10.1109/ISBI.2015.7163929

Focussed ion beam milling and scanning electron microscopy of brain tissue 10.3791/2588

Multi-Modal Optical Imaging of the Cerebellum in Animals 10.1007/s12311-015-0730-4

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window 10.1038/nprot.2009.89

Pansynaptic enlargement at adult cortical connections strengthened by experience 10.1093/cercor/bhs334

SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in C. elegans 10.1371/journal.pgen.1004777

PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein 10.1186/s40478-015-0200-8

Erratum: NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro (Chemical Communications (2015) DOI: 10.1039/c5cc06983a) 10.1039/c5cc90487k

The differential distribution of RAPTA-T in non-invasive and invasive breast cancer cells correlates with its anti-invasive and anti-metastatic effects 10.3390/ijms18091869

Globally optimal closed-surface segmentation for connectomics 10.1007/978-3-642-33712-3_56

Learning context cues for synapse segmentation 10.1109/TMI.2013.2267747

Correlative In Vivo 2 Photon and Focused Ion Beam Scanning Electron Microscopy of Cortical Neurons 10.1371/journal.pone.0057405

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro 10.1039/c5cc06983a

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration 10.1016/j.nbd.2014.08.027

A single epidermal stem cell strategy for safe ex vivo gene therapy 10.15252/emmm.201404353

A novel automated approach to serial block face dualbeam electron microscopy for the exploration of cortical circuits 10.1017/S1431927606065275

Multiphoton microscopy in brain imaging 10.1117/12.2084183

Rapid Functional Maturation of Nascent Dendritic Spines 10.1016/j.neuron.2008.10.054

Automated segmentation of synapses in 3D em data 10.1109/ISBI.2011.5872392

Glial glutamate transporters and maturation of the mouse somatosensory cortex 10.1093/cercor/13.10.1110

In vivo imaging of neural reactive plasticity after laser axotomy in cerebellar cortex 10.1117/12.2037276

In vivo two-photon imaging of climbing fibers plasticity after laser axotomy 10.1117/12.2032180

Growth of axons through a lesion in the intact CNS of fetal rat maintained in long-term culture 10.1098/rspb.1992.0146

Flash scanning electron microscopy 10.1007/978-3-642-40760-4_52

Synapse formation in adult barrel cortex following naturalistic environmental enrichment 10.1016/j.neuroscience.2011.10.040

NeuroMorph: A Toolset for the Morphometric Analysis and Visualization of 3D Models Derived from Electron Microscopy Image Stacks 10.1007/s12021-014-9242-5

Semiautomated correlative 3D electron microscopy of in vivo-imaged axons and dendrites 10.1038/nprot.2014.101

Imaging green fluorescent protein-labeled neurons using light and electron microscopy 10.1101/pdb.prot075127

Increasing depth resolution of electron microscopy of neural circuits using sparse tomographic reconstruction 10.1109/CVPR.2010.5539846

Modeling brain circuitry over a wide range of scales 10.3389/fnana.2015.00042

Learning structured models for segmentation of 2-D and 3-D imagery 10.1109/TMI.2014.2376274

Altered Synapse Formation in the Adult Somatosensory Cortex of Brain-Derived Neurotrophic Factor Heterozygote Mice 10.1523/JNEUROSCI.4040-03.2004

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity 10.1007/s00401-012-0963-y

In-vivo single neuron axotomy triggers axon regeneration to restore synaptic density in specific cortical circuits 10.1038/ncomms3038

Spine growth precedes synapse formation in the adult neocortex in vivo 10.1038/nn1747

High-throughput 3d cellular imaging 10.1017/S1431927609097037

The nature of the decrease in blood‐cerebrospinal fluid barrier exchange during postnatal brain development in the rat. 10.1113/jphysiol.1993.sp019760

Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period 10.1523/JNEUROSCI.1851-04.2004

Mitonuclear protein imbalance as a conserved longevity mechanism 10.1038/nature12188

Cell division by longitudinal scission in the insect endosymbiont Spiroplasma poulsonii 10.1128/mBio.00881-16

DualBeam slice & view: Practical aspects for collecting 3D cortex image data 10.1017/S1431927606065901

REPAIR AND RECOVERY FOLLOWING SPINAL CORD INJURY IN A NEONATAL MARSUPIAL (MONODELPHIS DOMESTICA) 10.1111/j.1440-1681.1995.tb02060.x

Serial section scanning electron microscopy of adult brain tissue using focused ion beam milling 10.1523/JNEUROSCI.3189-07.2008

GAD67-Mediated GABA Synthesis and Signaling Regulate Inhibitory Synaptic Innervation in the Visual Cortex 10.1016/j.neuron.2007.05.015

Supervoxel-based segmentation of mitochondria in em image stacks with learned shape features 10.1109/TMI.2011.2171705

FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra 10.1093/hmg/ddt530

Automated detection and segmentation of synaptic contacts in nearly isotropic serial electron microscopy images 10.1371/journal.pone.0024899

Analysis of centriole elimination during C. elegans oogenesis 10.1242/dev.075440

Development of thalamocortical projections in the South American gray short-tailed opossum (Monodelphis domestica) 10.1002/(SICI)1096-9861(19980907)398:4<491::AID-CNE3>3.0.CO;2-Y

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion 10.1038/nn.3662

GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons 10.1523/JNEUROSCI.3189-11.2012

Primary sensory afferent innervation of the developing superficial dorsal horn in the South American opossum Monodelphis domestica 10.1002/cne.20864

TGF-β receptor type II and fetuin in the developing sheep neocortex 10.1007/s004410050958

Plasticity of astrocytic coverage and glutamate transporter expression in adult mouse cortex 10.1371/journal.pbio.0040343

Response: Use-dependent inhibition of dendritic spines 10.1016/S0166-2236(02)02262-2

Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo 10.1523/JNEUROSCI.0302-06.2006

Multicut brings automated neurite segmentation closer to human performance 10.1038/nmeth.4151

Fetuin expression in the dorsal root ganglia and trigeminal ganglia of perinatal rats 10.1016/S0736-5748(97)00030-0

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation 10.7554/eLife.05793

Increased axonal bouton dynamics in the aging mouse cortex 10.1073/pnas.1218731110

Neurodegeneration: Cold shock protects the brain 10.1038/nature14195

The nature and composition of the internal environment of the developing brain 10.1023/A:1006943926765

Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice 10.1016/S0896-6273(02)00663-3

Neural plasticity explored by correlative two-photon and electron/SPIM microscopy 10.1117/12.2032505

Imaging liver and brain glycogen metabolism at the nanometer scale 10.1016/j.nano.2014.09.007

In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex 10.1073/pnas.1219256110

The relationship between PSD-95 clustering and spine stability In Vivo 10.1523/JNEUROSCI.3353-13.2014

A protocol for preparing GFP-labeled neurons previously imaged in vivo and in slice preparations for light and electron microscopic analysis 10.1038/nprot.2009.114

BMP signaling specifies the development of a large and fast CNS synapse 10.1038/nn.3414

Is EM dead? 10.1242/jcs.124123

Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs 10.1038/nn1334

Seeded watershed cut uncertainty estimators for guided interactive segmentation 10.1109/CVPR.2012.6247747

PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling 10.1083/jcb.200805132

Experience-dependent and cell-type-specific spine growth in the neocortex 10.1038/nature04783

Transient and persistent dendritic spines in the neocortex in vivo 10.1016/j.neuron.2005.01.003

Dendritic spine plasticity-Current understanding from in vivo studies 10.1016/j.brainresrev.2008.01.002

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex 10.1038/nature01273

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons 10.1093/hmg/ddw418

In vivo reactive neural plasticity investigation by means of correlative two photon: Electron microscopy 10.1117/12.2005953

Delayed and temporally imprecise neurotransmission in reorganizing cortical microcircuits 10.1523/JNEUROSCI.4583-14.2015

Altered synaptic dynamics during normal brain aging 10.1523/JNEUROSCI.4825-12.2013

Development of motoneurons and primary sensory afferents in the thoracic and lumbar spinal cord of the South American opossum Monodelphis domestica 10.1002/(SICI)1096-9861(19991129)414:4<423::AID-CNE1>3.0.CO;2-J

Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton 10.1016/j.neuron.2004.09.022

Carving: Scalable interactive segmentation of neural volume electron microscopy images 10.1007/978-3-642-23623-5_82

Imaging of experience-dependent structural plasticity in the mouse neocortex in vivo 10.1016/j.bbr.2008.04.005

Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex 10.1016/j.neuron.2006.02.017

Morphological and molecular heterogeneity in release sites of single neurons 10.1046/j.1460-9568.2003.02572.x

Correlative in vivo 2-photon imaging and focused ion beam scanning electron microscopy: 3D analysis of neuronal ultrastructure 10.1016/B978-0-12-801075-4.00016-1

Barriers in the immature brain 10.1023/A:1006991809927

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from ¹³C-glucose 10.1016/j.jchemneu.2015.09.003

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535

Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics 10.1038/nmeth.3292

Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images 10.7554/eLife.29315

Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions 10.1038/s41467-018-05976-x

The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63 10.1101/431106

Block face scanning electron microscopy of fluorescently labeled axons without using near infra-red branding 10.3389/fnana.2018.00088

In vivo modeling of human neuron dynamics and down syndrome 10.1126/science.aau1810

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity 10.1186/s13024-017-0220-x

The effects of aging on neuropil structure in mouse somatosensory cortex—A 3D electron microscopy analysis of layer 1 10.1371/journal.pone.0198131

NeuroMorph: A Software Toolset for 3D Analysis of Neurite Morphology and Connectivity 10.3389/fnana.2018.00059

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency 10.1038/s41380-018-0132-3

Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: A TEM/NanoSIMS study 10.1039/c7mt00153c

Locally coordinated synaptic plasticity of visual cortex neurons in vivo 10.1126/science.aao0862

Ultrastructural basis of strong unitary inhibition in a binaural neuron 10.1113/JP276015

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects 10.1038/s41598-017-13786-2

Cellular Uptake and Intracellular Trafficking of Poly(N-(2-Hydroxypropyl) Methacrylamide) 10.1021/acs.biomac.8b01372

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments 10.1038/s41380-018-0226-y

Neuron Segmentation with High-Level Biological Priors 10.1109/TMI.2017.2712360

Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution 10.1038/s41592-019-0641-2

Publisher Correction: Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution 10.1038/s41592-019-0695-1

Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation 10.1101/2020.03.02.972695

Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1 10.1126/sciadv.aaz0517

Maturation of complex synaptic connections of layer 5 cortical axons in the posterior thalamic nucleus requires SNAP25 10.1101/2020.05.20.093070

Nano-imaging trace elements at organelle levels in substantia nigra overexpressing α-synuclein to model Parkinson’s disease 10.1038/s42003-020-1084-0

Early invasion of uropathogenic Escherichia coli into the bladder wall by solitary bacteria that are protected from antibiotics and neutrophil swarms in an organoid model 10.1101/2020.10.29.358622

Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation 10.7554/eLife.56384

Maturation of Complex Synaptic Connections of Layer 5 Cortical Axons in the Posterior Thalamic Nucleus Requires SNAP25 10.1093/cercor/bhaa379

Dynamic persistence of intracellular bacterial communities of uropathogenic Escherichia coli in a human bladder-chip model of urinary tract infections 10.1101/2021.01.03.424836

NeuroMechFly, a neuromechanical model of adult Drosophila melanogaster 10.1101/2021.04.17.440214

Vincent Delorme

Delorme Vincent

ORCID: 0000-0001-5235-7069

Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent. 10.1016/j.bmc.2020.115797

Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. 10.1016/j.stemcr.2019.10.002

Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis. 10.1016/j.bioorg.2018.08.025

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains. 10.3389/fcimb.2018.00114

Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-018-25177-2

Mycobacterium tuberculosis Infection and Innate Responses in a New Model of Lung Alveolar Macrophages. 10.3389/fimmu.2018.00438

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. 10.1038/s41598-017-11843-4

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 10.1016/j.celrep.2017.08.101

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-017-05453-3

Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis. 10.1128/aac.02637-16

Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. 10.1021/acschembio.7b00091

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. 10.1126/science.aag1006

High-Content Screening of Raw Actinomycete Extracts for the Identification of Antituberculosis Activities. 10.1177/1087057116675887

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. 10.1039/c5ob02630j

Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays. 10.1007/978-1-4939-2450-9_24

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1. 10.1021/cb5007163

Supported inhibitor for fishing lipases in complex biological media and mass spectrometry identification. 10.1016/j.biochi.2014.07.015

A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114

Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones. 10.1016/j.ejmech.2012.10.040

MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth. 10.1371/journal.pone.0046493

Inhibition of phospholipase A1, lipase and galactolipase activities of pancreatic lipase-related protein 2 by methyl arachidonyl fluorophosphonate (MAFP). 10.1016/j.bbalip.2012.07.014

Effects of surfactants on lipase structure, activity, and inhibition. 10.1007/s11095-010-0362-9

CO2 binding by dynamic combinatorial chemistry: an environmental selection. 10.1021/ja909975q

Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function. 10.1096/fj.09-144766

Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases. 10.1021/jm301216x

Phenotypic Screening for Drug Discovery in Tuberculosis https://doi.org/10.1039/9781839160721-00198

Neeraj Dhar

Dhar Neeraj

ORCID: 0000-0002-5887-8137

Dynamic Persistence of Antibiotic-Stressed Mycobacteria 10.1126/science.1229858

Mycobacterium tuberculosisEspB binds phospholipids and mediates EsxA-independent virulence 10.1111/mmi.12336

Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria 10.1038/ncomms3470

EspD Is Critical for the Virulence-Mediating ESX-1 Secretion System in Mycobacterium tuberculosis 10.1128/JB.06417-11

Malachite Green Interferes with Postantibiotic Recovery of Mycobacteria 10.1128/AAC.00406-12

Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis 10.1128/AAC.01125-12

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis 10.1126/scitranslmed.3004395

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis 10.1016/j.vaccine.2011.07.039

Development of a repressible mycobacterial promoter system based on two transcriptional repressors 10.1093/nar/gkq235

Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice 10.1073/pnas.1003219107

Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis 10.1128/AAC.00821-10

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis 10.1126/science.1171583

Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacterium tuberculosis infection in guinea pigs 10.1016/j.vaccine.2009.09.121

Enhanced and Enduring Protection against Tuberculosis by Recombinant BCG-Ag85C and Its Association with Modulation of Cytokine Profile in Lung 10.1371/journal.pone.0003869

Microbial phenotypic heterogeneity and antibiotic tolerance 10.1016/j.mib.2006.12.007

Elicitation of efficient, protective immune responses by using DNA vaccines against tuberculosis 10.1016/j.vaccine.2005.03.056

Increased expression of Mycobacterium tuberculosis 19 kDa lipoprotein obliterates the protective efficacy of BCG by polarizing host immune responses to the Th2 subtype 10.1111/j.1365-3083.2005.01569.x

Immunogenicity of recombinant BCG vaccine strains overexpressing components of the antigen 85 complex of Mycobacterium tuberculosis 10.1007/s00430-002-0170-x

Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs 10.1046/j.1365-2958.2003.03712.x

Modulation of host immune responses by overexpression of immunodominant antigens of Mycobacterium tuberculosis in bacille Calmette-Guerin 10.1046/j.1365-3083.2003.01321.x

Skewing of the Th1/Th2 responses in mice due to variation in the level of expression of an antigen in a recombinant BCG system 10.1016/S0165-2478(03)00043-9

4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity 10.1021/jm5005978

Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants 10.1111/mmi.12546

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism 10.1038/ncomms4369

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations 10.1039/c4lc00109e

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis 10.1128/AAC.02410-14

Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion In Vitro Does Not Always Correlate with Attenuation of Virulence 10.1128/JB.00967-13

Bioluminescence for assessing drug potency against nonreplicating Mycobacterium tuberculosis 10.1128/AAC.00528-15

2-carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1 10.1021/cb5007163

Rapid cytolysis of mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic 10.1128/AAC.03461

Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells 10.1016/j.chom.2014.12.008

Stress and host immunity amplify mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms 10.1016/j.chom.2014.11.016

Single-cell analysis of mycobacteria using microfluidics and time-lapse microscopy 10.1007/978-1-4939-2450-9_14

Simple and rapid method to determine antimycobacterial potency of compounds by using autoluminescent mycobacterium tuberculosis 10.1128/AAC.03205-14

The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo 10.1128/JB.01346-13

EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis 10.1111/mmi.12718

Recombinant BCG approach for development of vaccines: Cloning and expression of immunodominant antigens of M. tuberculosis 10.1016/S0378-1097(00)00353-0

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β- d -ribose Oxidase 10.1021/acsinfecdis.5b00065

Combinations of β-lactam antibiotics currently in clinical trials are efficacious in a dhp-i-deficient mouse model of tuberculosis infection 10.1128/AAC.01063-15

Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic 10.1128/AAC.03461-14

Erratum to The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo [Journal of Bacteriology, 196, 19, (2014) 3441-3451] DOI: 10.1128/JB.02332-14 10.1128/JB.02332-14

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor 10.1016/j.ebiom.2016.05.006

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535

An Amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase is required for mycobacterial cell division 10.1038/s41598-017-01184-7

Division site selection linked to inherited cell surface wave troughs in mycobacteria 10.1038/nmicrobiol.2017.94

Elucidating the role of (p)ppGpp in mycobacterial persistence against antibiotics 10.1002/iub.1888

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress 10.15252/embj.2019101876

Computational Analysis of the Mutual Constraints between Single‐Cell Growth and Division Control Models 10.1002/adbi.201900103

A lung-on-chip model reveals an essential role for alveolar epithelial cells in controlling bacterial growth during early tuberculosis 10.1101/2020.02.03.931170

Driving polar growth 10.7554/eLife.57043

Dielectrophoresis as a single cell characterization method for bacteria 10.1088/2057-1976/3/1/015005

Early invasion of uropathogenic Escherichia coli into the bladder wall by solitary bacteria that are protected from antibiotics and neutrophil swarms in an organoid model 10.1101/2020.10.29.358622

A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth 10.7554/eLife.59961

Dynamic persistence of intracellular bacterial communities of uropathogenic Escherichia coli in a human bladder-chip model of urinary tract infections 10.1101/2021.01.03.424836

Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model 10.15252/embr.202152744

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection 10.7554/eLife.66481

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model 10.1016/j.celrep.2021.109351

Jana Korduláková

Korduláková Jana

ORCID: 0000-0003-2834-0165

New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action 10.1016/j.ejmech.2018.04.017

Impact of the epoxide hydrolase EphD on the metabolism of mycolic acids in mycobacteria. 10.1074/jbc.ra117.000246

Mechanochemical synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity 10.3390/molecules22091457

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression 10.1038/srep43495

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535

Pyrrolidinone and pyrrolidine derivatives: Evaluation as inhibitors of InhA and Mycobacterium tuberculosis 10.1016/j.ejmech.2016.07.028

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA 10.1038/ncomms10906

Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth 10.1016/j.ejmech.2015.06.035

DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization 10.1021/acschembio.5b00237

Lead selection and characterization of antitubercular compounds using the Nested Chemical Library 10.1016/j.tube.2015.02.028

Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone 10.1021/id500032q

Erratum for Ang et al., An ethA-ethR-Deficient Mycobacterium bovis BCG Mutant Displays Increased Adherence to Mammalian Cells and Greater Persistence In Vivo, Which Correlate with Altered Mycolic Acid Composition. 10.1128/IAI.02884-14

Erratum for Boldrin et al., The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo. 10.1128/JB.02332-14

The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo 10.1128/JB.01346-13

Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid--monoacylated phosphatidylinositol dimannoside. 10.1016/j.pep.2014.04.014

An ethA-ethR-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo, which correlate with altered mycolic acid composition 10.1128/IAI.01332-13

A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria 10.1074/jbc.M112.400986

A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone 10.1074/jbc.M112.400994

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane 10.1038/nchembio.794

Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster 10.4149/gpb_2011_03_239

The structure-activity relationship of urea derivatives as anti-tuberculosis agents 10.1016/j.bmc.2011.07.034

Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring 10.1016/j.ejmech.2010.09.048

Molecular Basis of Phosphatidyl-myo-inositol Mannoside Biosynthesis and Regulation in Mycobacteria 10.1074/jbc.R110.168328

AftD, a novel essential arabinofuranosyltransferase from mycobacteria 10.1093/glycob/cwp116

Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria. Implications for catalysis 10.1074/jbc.M109.003947

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Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of Mycobacterium species 10.1074/jbc.M303639200

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The Two-Component Locus MSMEG_0244/0246 Together With MSMEG_0243 Affects Biofilm Assembly in M. smegmatis Correlating With Changes in Phosphatidylinositol Mannosides Acylation 10.3389/fmicb.2020.570606

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Fragment-based design of mycobacterium tuberculosis inha inhibitors 10.1021/acs.jmedchem.0c00007

Trehalose Conjugation Enhances Toxicity of Photosensitizers against Mycobacteria 10.1021/acscentsci.8b00962

Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents 10.1016/j.chembiol.2019.02.013

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria 10.1074/jbc.M702087200

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β- d -ribofuranose 2′-Oxidase 10.1021/acs.jmedchem.9b00912

Benzothiazinones Kill Mycobacterium tuberculosis by blocking Arabinan synthesis 10.1126/science.1171583

Alkylamino derivatives of N-benzylpyrazine-2-carboxamide: synthesis and antimycobacterial evaluation 10.1039/c5md00178a

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis 10.1128/AAC.00433-07

New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053 10.1021/acsinfecdis.9b00388

Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis: PimA is essential for growth of mycobacteria 10.1074/jbc.M204060200

Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis 10.1371/journal.ppat.0030062

Identification of a novel galactosyl transferase involved in biosynthesis of the mycobacterial cell wall 10.1128/JB.00489-06

A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis 10.1021/acsinfecdis.0c00325

Design and Synthesis of Pyrano[3,2-b]indolones Showing Antimycobacterial Activity 10.1021/acsinfecdis.0c00622

p-hydroxybenzoic acid synthesis in Mycobacterium tuberculosis 10.1074/jbc.M508332200

Priscille Brodin

Brodin Priscille

ORCID: 0000-0003-0991-7344

Email: priscille.brodin@inserm.fr

How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011

Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227

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Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections 10.2217/nnm-2016-0364

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Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z

Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005 10.1016/j.drudis.2017.05.005.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535

Impact of pe_ pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis 10.3389/fcimb.2017.00137

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619

Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129 10.1002/cyto.a.23129.

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j

Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5

Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization 10.1016/j.str.2016.07.009

Mycolactone The amazing analgesic mycobacterial toxin 10.1051/medsci/20163202007

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297

2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650

High content screening in chemical biology: overview and main challenges 10.1051/medsci/20153102016

High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis 10.1128/aac.03705-14

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15

Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays 10.1007/978-1-4939-2450-9_24

A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening 10.3791/51114

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/jm500422b

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040

Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022

A novel specific edge effect correction method for RNA interference screenings 10.1093/bioinformatics/btr648

Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779

Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u

The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence 10.1371/journal.pone.0047573

Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis 10.1371/journal.pone.0026675

Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200076a

High-content screening in infectious diseases 10.1016/j.cbpa.2011.05.023

Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ 10.1099/mic.0.038133-0

High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100

High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery 10.4155/fmc.10.223

Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting 10.1016/j.biomaterials.2009.09.044

Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure 10.1177/1087057108328762

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis 10.1126/science.1171583

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Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507

Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033

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Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis 10.1371/journal.ppat.0030062

Protection against mycobacterium ulcerans lesion development by exposure to aquatic insect saliva 10.1371/journal.pmed.0040064

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An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis 10.1128/iai.74.4.2128-2137.2006

Benzofuro 3,2-f 1 benzopyrans: A new class of antitubercular agents 10.1016/j.bmc.2006.03.033

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High frequency of CD4(+) T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection 10.1128/iai.02086-05

Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence 10.1128/jb.00631-06

Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis 10.1016/j.tube.2004.09.009

Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200

Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics 10.1099/mic.0.27799-0

Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions 10.1016/j.jmb.2005.05.049

Tuberculosis: from genome to vaccine 10.1586/14760584.4.4.541

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6 10.1128/iai.72.4.2170-2176.2004

Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468

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CD8(+)-T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family 10.1128/iai.71.12.7173-7177.2003

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A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299

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Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides 10.1021/bi015732y

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x

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Inhibition of the human immunodeficiency virus type 1 DNA integration by modified oligonucleotides 10.1023/a:1026631910681

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Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides 10.1080/07328319908044831

Optimization of alternate-strand triple helix formation at the 5 '-TpA-3 ' and 5 '-ApT-3 ' junctions 10.1093/nar/27.15.3029

A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus 10.1074/jbc.272.25.16010

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371

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Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091

Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017 10.1016/j.mib.2017.11.017.

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101 10.1016/j.celrep.2017.08.101.

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114 10.1073/pnas.1707840114.

Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry 10.1128/jvi.01982-17

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125

Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025

Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation 10.3389/fimmu.2018.00086

Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis 10.1128/aac.00359-18

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4

Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030

Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101

Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129

A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening 10.1002/cyto.a.20627

Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360

Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation 10.1074/mcp.RA119.001316

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902

Mitochondrial Dynamics and Activity in Legionella-Infected Cells 10.1007/978-1-4939-9048-1_13

Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258

Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication 10.1128/jvi.02009-18

A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J

Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls 10.3390/toxins11090516

Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies. 10.3389/fimmu.2020.569127

Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity. 10.1021/acsinfecdis.9b00277

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds. 10.1371/journal.pone.0227224

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis. 10.1016/j.vaccine.2019.11.085

IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551

Worms' Antimicrobial Peptides. 10.3390/md17090512

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Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. 10.1371/journal.pone.0198226

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g

Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38

Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82

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Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505

José Antonio Aínsa Claver

Aínsa Claver José Antonio / José Antonio Aínsa

ORCID: 0000-0003-2076-844X

Selective Targeting of Human and Animal Pathogens of the Helicobacter Genus by Flavodoxin Inhibitors: Efficacy, Synergy, Resistance and Mechanistic Studies 10.3390/ijms221810137

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone 10.1016/j.ejmech.2010.09.056

Transcriptional analysis of and resistance level conferred by the aminoglycoside acetyltransferase gene aac(2')-Id from Mycobacterium smegmatis. 10.1093/jac/dkm440

Aminoglycoside 2'-N-acetyltransferase genes are universally present in mycobacteria: Characterization of the aac(2')-lc gene from Mycobacterium tuberculosis and the aac(2')-ld gene from Mycobacterium smegmatis 10.1046/j.1365-2958.1997.3471717.x

Construction of a family of Mycobacterium/Escherichia coli shuttle vectors derived from pAL5000 and pACYC184: Their use for cloning an antibiotic-resistance gene from Mycobacterium fortuitum 10.1016/0378-1119(96)00202-8

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux 10.1038/nm.3458

Analysis of Mutations in Streptomycin-Resistant Strains Reveals a Simple and Reliable Genetic Marker for Identification of the Mycobacterium tuberculosis Beijing Genotype 10.1128/JCM.01944-12

Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages 10.1016/j.jep.2013.01.013

Role of the Mmr Efflux Pump in Drug Resistance in Mycobacterium tuberculosis 10.1128/AAC.01482-12

Mycobacterial Shuttle Vectors Designed for High-Level Protein Expression in Infected Macrophages 10.1128/AEM.01674-12

Functional and Genetic Characterization of the Tap Efflux Pump in Mycobacterium bovis BCG 10.1128/AAC.05946-11

A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors 10.1021/jm2006063

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique 10.1016/j.jep.2011.04.062

The complex whiJ locus mediates environmentally sensitive repression of development of Streptomyces coelicolor A3(2) 10.1007/s10482-010-9443-3

Role of the Mycobacterium tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth 10.1128/AAC.00550-09

Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG 10.1093/jac/dkl510

Novel streptomycin resistance gene from Mycobacterium fortuitum 10.1128/AAC.00223-06

Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitum 10.1093/jac/dki436

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Characterization of P55, a multidrug efflux pump in Mycobacterium bovis and Mycobacterium tuberculosis 10.1128/AAC.45.3.800-804.2001

WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2) 10.1128/JB.182.19.5470-5478.2000

A response regulator-like protein that functions at an intermediate stage of sporulation in Streptomyces coelicolor A3(2) 10.1046/j.1365-2958.1999.01630.x

Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs. 10.1586/eri.12.89

Lipid transport in Mycobacterium tuberculosis and its implications in virulence and drug development 10.1016/j.bcp.2015.05.001

Measuring efflux and permeability in mycobacteria. 10.1007/978-1-4939-2450-9_13

Antituberculosis drugs: reducing efflux = increasing activity 10.1016/j.drudis.2017.01.002

Discovery of antimicrobial compounds targeting bacterial type FAD synthetases 10.1080/14756366.2017.1411910

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase. 10.1016/j.tube.2018.08.004

Total Synthesis of Ripostatin B and Structure-Activity Relationship Studies on Ripostatin Analogs. 10.1021/acs.joc.8b00193

Ionophore A23187 shows anti-tuberculosis activity and synergy with tebipenem. 10.1016/j.tube.2017.09.001

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. 10.1021/acs.jmedchem.7b01570

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535

Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions. 10.1021/acsinfecdis.6b00158

How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011

Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis. 10.3389/fmicb.2018.01659

Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis. 10.1128/aac.00359-18

Inhibition of drug efflux in mycobacteria with phenothiazines and other putative efflux inhibitors. 10.2174/157489111796064579

Isolation by genetic labeling of a new mycobacterial plasmid, pJAZ38, from Mycobacterium fortuitum. 10.1128/jb.179.13.4115-4122.1997

New active formulations against M. tuberculosis: Bedaquiline encapsulation in lipid nanoparticles and chitosan nanocapsules https://doi.org/10.1016/j.cej.2017.12.110

Polypeptidic Micelles Stabilized with Sodium Alginate Enhance the Activity of Encapsulated Bedaquiline 10.1002/mabi.201800397

Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant Staphylococcus aureus (MRSA) 10.1371/journal.pone.0220684

In silico discovery and biological validation of ligands of FAD synthase, a promising new antimicrobial target 10.1371/journal.pcbi.1007898

Nanotechnology‐Based Targeted Drug Delivery: An Emerging Tool to Overcome Tuberculosis 10.1002/adtp.202000113

Nathalie deboosere

deboosere Nathalie

ORCID: 0000-0002-2873-5485

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 10.1016/j.celrep.2017.08.101

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. 10.3390/toxins9070227

Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. 10.1021/acschembio.7b00091

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. 10.1111/cmi.12619

A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114

Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces. 10.1016/j.fm.2012.04.007

Viral elution and concentration method for detection of influenza A viruses in mud by real-time RT-PCR. 10.1016/j.jviromet.2011.10.013

Comparison of chlorine and peroxyacetic-based disinfectant to inactivate Feline calicivirus, Murine norovirus and Hepatitis A virus on lettuce. 10.1016/j.ijfoodmicro.2011.08.011

Direct detection of highly pathogenic avian influenza A/H5N1 virus from mud specimens. 10.1016/j.jviromet.2011.06.002

Development and validation of a concentration method for the detection of influenza a viruses from large volumes of surface water. 10.1128/aem.02484-10

A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries. 10.1016/j.fm.2010.05.018

Assessment of the removal and inactivation of influenza viruses H5N1 and H1N1 by drinking water treatment. 10.1016/j.watres.2010.01.013

Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables. 10.1016/j.ijfoodmicro.2005.11.007

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Host-pathogen systems for early drug discovery against tuberculosis. 10.1016/j.mib.2017.11.017

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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262

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Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens. 10.1086/421468

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Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. 10.1046/j.1365-2958.2002.03237.x

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Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483

Vinayak Singh

Singh Vinayak / Vin

ORCID: 0000-0001-9002-2489

Identification and validation of novel drug targets in Mycobacterium tuberculosis 10.1016/j.drudis.2016.09.010

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis 10.1021/acsinfecdis.6b00102

Overexpression of Rv3097c in Mycobacterium bovis BCG abolished the efficacy of BCG vaccine to protect against Mycobacterium tuberculosis infection in mice 10.1016/j.vaccine.2011.04.086

Downregulation of Rv0189c, encoding a dihydroxyacid dehydratase, affects growth of Mycobacterium tuberculosis in vitro and in mice 10.1099/mic.0.042358-0

3D-QSAR and molecular modeling studies on 2,3-dideoxy hexenopyranosid-4-uloses as anti-tubercular agents targeting alpha-mannosidase 10.1016/j.bioorg.2015.02.001

Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis 10.1038/srep27792

Deoxysugars as antituberculars and alpha-mannosidase inhibitors 10.1128/AAC.02715-13

Biochemical and transcription analysis of acetohydroxyacid synthase isoforms in Mycobacterium tuberculosis identifies these enzymes as potential targets for drug development 10.1099/mic.0.041343-0

Identification of Aminopyrimidine-Sulfonamides as Potent Modulators of Wag31-mediated Cell Elongation in Mycobacteria 10.1111/mmi.13535

The complex mechanism of antimycobacterial action of 5-fluorouracil 10.1016/j.chembiol.2014.11.006

Genome-Wide Transposon Mutagenesis in Mycobacterium tuberculosis and Mycobacterium smegmatis 10.1007/978-1-4939-6472-7_21

N-Acetylglucosamine-1-phosphate transferase, WecA, as a validated drug target in Mycobacterium tuberculosis. 10.1128/aac.01310-17

Detection of Mycobacterium tuberculosis bacilli in bio-aerosols from untreated TB patients 10.12688/gatesopenres.12758.1

Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis 10.1021/acs.jmedchem.7b01622

Hit discovery of Mycobacterium tuberculosis inosine 5′-monophosphate dehydrogenase, GuaB2, inhibitors 10.1016/j.bmcl.2018.04.045

Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents 10.1021/acs.jmedchem.7b01839

Detection of Mycobacterium tuberculosis bacilli in bio-aerosols from untreated TB patients 10.12688/gatesopenres.12758.2

Synthesis and Structure–Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH 10.1016/j.ejmech.2019.04.027

Drug-resistance in Mycobacterium tuberculosis: where we stand 10.1039/c9md00057g

Synergistic enhancement of beta-lactam antibiotics by modified tunicamycin analogs TunR1 and TunR2 10.1038/s41429-019-0220-x

Real-time investigation of tuberculosis transmission: Developing the respiratory aerosol sampling chamber (RASC) 10.1371/journal.pone.0146658

The quest for the holy grail: new antitubercular chemical entities, targets and strategies 10.1016/j.drudis.2020.02.003

Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity 10.1021/acsinfecdis.0c00252

Design, synthesis and characterization of novel 2-(2, 3-dichlorophenyl)-5-aryl-1,3,4-oxadiazole derivatives for their anti-tubercular activity against Mycobacterium tuberculosis 10.1016/j.cdc.2020.100431

Current Scenario and Future Prospect in the Management of COVID-19 10.2174/0929867327666200908113642

6,11-Dioxobenzo[f]pyrido[1,2-a]indoles Kill Mycobacterium tuberculosis by Targeting Iron–Sulfur Protein Rv0338c (IspQ), A Putative Redox Sensor 10.1021/acsinfecdis.0c00531

Current advances in the clinical development of anti-tubercular agents. 10.1016/j.tube.2020.101989

Antitubercular 2-Pyrazolylpyrimidinones: Structure–Activity Relationship and Mode-of-Action Studies 10.1021/acs.jmedchem.0c01727

Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host-Di-rected Therapies. 10.2174/1568026621999201211200447

Developing Synergistic Drug Combinations To Restore Antibiotic Sensitivity in Drug-Resistant Mycobacterium tuberculosis 10.1128/AAC.02554-20

An ABC transporter Wzm–Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria 10.1073/pnas.2023663118

Strategies to Combat Multi-Drug Resistance in Tuberculosis 10.1021/acs.accounts.0c00878

Rv0684/fusA1, an Essential Gene, Is the Target of Fusidic Acid and Its Derivatives in Mycobacterium tuberculosis 10.1021/acsinfecdis.1c00195

Current strategies in targeted anticancer drug delivery systems to brain 10.1016/b978-0-323-85503-7.00038-9

Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure–Activity Relationship, Metabolism, and Biology Triaging 10.1021/acs.jmedchem.1c00707

Perspectives on RNA Vaccine Candidates for COVID-19 10.3389/fmolb.2021.635245

Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiatric Adverse Events in COVID-19 Patients: Navigating the Uncharted 10.3389/fmolb.2021.627723

Joanna Evans

Evans Joanna

ORCID: 0000-0002-4139-9527

Email: Joanna.evans@crick.ac.uk

Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus 10.1128/aac.00978-21

A novel insertion sequence, ISPA26, in oprD of Pseudomonas aeruginosa is associated with carbapenem resistance. 10.1128/AAC.00837-07

Recent and rapid emergence of W-Beijing strains of Mycobacterium tuberculosis in Cape Town, South Africa. 10.1086/592575

Rapid genotypic assays to identify drug-resistant Mycobacterium tuberculosis in South Africa. 10.1093/jac/dkn433

Novel multiplex allele-specific PCR assays for the detection of resistance to second-line drugs in Mycobacterium tuberculosis. 10.1093/jac/dkq047

Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase. 10.1016/j.bmc.2014.01.017

The complex mechanism of antimycobacterial action of 5-fluorouracil. 10.1016/j.chembiol.2014.11.006

Nucleotide Metabolism and DNA Replication. 10.1128/microbiolspec.mgm2-0001-2013

The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis. 10.3389/fmicb.2015.00812

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis. 10.1021/acsinfecdis.6b00150

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535

The Influence of HIV on the Evolution of Mycobacterium tuberculosis. 10.1093/molbev/msx107

Priming the tuberculosis drug pipeline: new antimycobacterial targets and agents. 10.1016/j.mib.2018.02.006

In vitro efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against Mycobacterium tuberculosis. 10.1128/aac.01010-19

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site. 10.1038/s41467-020-20224-x

Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-L-cysteine Synthetase (CoaB) Activity 10.1021/acsinfecdis.0c00904

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference 10.1101/2020.09.04.280388

Ruben Hartkoorn

Hartkoorn Ruben / Ruben C. Hartkoorn

ORCID: 0000-0001-7315-1553

A druggable secretory protein maturase of Toxoplasma essential for invasion and egress 10.7554/eLife.27480

Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis 10.1021/jacs.7b03382

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535

MoS2/TiO2/SiNW surface as an effective substrate for LDI-MS detection of glucose and glutathione in real samples 10.1016/j.talanta.2017.04.061

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis 10.1021/acsinfecdis.6b00102

Micrococcin P1-A bactericidal thiopeptide active against Mycobacterium tuberculosis 10.1016/j.tube.2016.07.011

2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163

Bioluminescence for Assessing Drug Potency against Nonreplicating Mycobacterium tuberculosis 10.1128/aac.00528-15

Lead selection and characterization of antitubercular compounds using the Nested Chemical Library 10.1016/j.tube.2015.02.028

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis 10.1128/aac.00778-15

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG 10.1016/j.chembiol.2015.05.016

Whole cell screen based identification of spiropiperidines with potent antitubercular properties 10.1016/j.bmcl.2015.05.087

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion 10.1016/j.chom.2014.09.008

Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants 10.1111/mmi.12546

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis 10.1128/aac.00037-14

Mechanism of Action of 5-Nitrothiophenes against Mycobacterium tuberculosis 10.1128/aac.02693-13

Rv2466c Mediates the Activation of TP053 To Kill Replicating and Non-replicating Mycobacterium tuberculosis 10.1021/cb500149m

Towards a new combination therapy for tuberculosis with next generation benzothiazinones 10.1002/emmm.201303575

Synthesis and Antimycobacterial Activity of 2,1 '-Dihydropyridomycins 10.1021/ml300385q

Genome-Wide Definition of the SigF Regulon in Mycobacterium tuberculosis 10.1128/jb.06692-11

In Vitro Combination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis 10.1128/aac.01476-12

Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis 10.1128/aac.01125-12

Towards a new tuberculosis drug: pyridomycin - nature's isoniazid 10.1002/emmm.201201689

Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein 10.1371/journal.ppat.1002621

Tuberculosis drugs: new candidates and how to find more 10.2217/fmb.11.46

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms 10.1097/FPC.0b013e328335b02d

Leads for antitubercular compounds from kinase inhibitor library screens 10.1016/j.tube.2010.09.001

Sigma Factor F Does Not Prevent Rifampin Inhibition of RNA Polymerase or Cause Rifampin Tolerance in Mycobacterium tuberculosis 10.1128/jb.00687-10

Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis 10.1128/aac.00821-10

Intracellular 'boosting' of darunavir using known transport inhibitors in primary PBMC 10.1111/j.1365-2125.2009.03462.x

Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes 10.1093/jac/dkp335

Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir 10.1038/bjp.2008.320

A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin 10.1016/j.jchromb.2007.07.005

Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein 10.1016/j.tube.2006.12.001

Tacrine-induced liver damage: an analysis of 19 candidate genes 10.1097/FPC.0b013e3282f1f12b

Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug 10.1136/ard.2005.049189

Low levels of pyrazinamide and ethambutol in children with tuberculosis and impact of age, nutritional status, and human immunodeficiency virus infection 10.1128/aac.50.2.407-413.2006

In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine 10.1124/jpet..105.086272

Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP 10.1097/01.aids.0000194793.36175.40

Expression of P-glycoprotein, multidrug-resistance proteins 1 and 2 in CEM, CEMVBL, CEME1000, MDCKIIMRP1 and MDCKIIMRP2 cell lines 10.1097/01.aids.0000088212.77946.65

Pyrrolomycins Are Potent Natural Protonophores 10.1128/AAC.01450-19

Intragenic Distribution of IS 6110 in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic Resistance 10.1128/Spectrum.00019-21

Liliana Rodrigues

Rodrigues Liliana

ORCID: 0000-0002-2094-2666

Measuring efflux and permeability in mycobacteria. 10.1007/978-1-4939-2450-9_13

Role of the Mmr efflux pump in drug resistance in Mycobacterium tuberculosis. 10.1128/aac.01482-12

Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs. 10.1586/eri.12.89

Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. 10.1371/journal.pone.0034538

Genetic response of Salmonella enterica serotype Enteritidis to thioridazine rendering the organism resistant to the agent. 10.1016/j.ijantimicag.2011.08.013

Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex. 10.1016/j.meegid.2011.08.009

Inhibition of drug efflux in mycobacteria with phenothiazines and other putative efflux inhibitors. 10.2174/157489111796064579

Ethidium bromide transport across Mycobacterium smegmatis cell-wall: correlation with antibiotic resistance. 10.1186/1471-2180-11-35

Physiological characterisation of the efflux pump system of antibiotic-susceptible and multidrug-resistant Enterobacter aerogenes. 10.1016/j.ijantimicag.2010.06.036

Molecular tools for rapid identification and novel effective therapy against MDRTB/XDRTB infections. 10.1586/eri.10.20

Evaluation of efflux activity of bacteria by a semi-automated fluorometric system. 10.1007/978-1-60327-279-7_12

Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli. 10.1186/1754-1611-3-18

Identification of nontuberculous mycobacteria in clinical samples using molecular methods: a 3-year study. 10.1111/j.1469-0691.2009.03076.x

The role of efflux pumps in macrolide resistance in Mycobacterium avium complex. 10.1016/j.ijantimicag.2009.07.010

An AcrAB-mediated multidrug-resistant phenotype is maintained following restoration of wild-type activities by efflux pump genes and their regulators. 10.1016/j.ijantimicag.2009.06.029

pH Modulation of efflux pump activity of multi-drug resistant Escherichia coli: protection during its passage and eventual colonization of the colon. 10.1371/journal.pone.0006656

New methods for the identification of efflux mediated MDR bacteria, genetic assessment of regulators and efflux pump constituents, characterization of efflux systems and screening for inhibitors of efflux pumps. 10.2174/138945008785747734

Demonstration of intrinsic efflux activity of Escherichia coli K-12 AG100 by an automated ethidium bromide method. 10.1016/j.ijantimicag.2007.12.015

Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis. 10.1093/jac/dkn070

Antibiotic stress, genetic response and altered permeability of E. coli. 10.1371/journal.pone.0000365

Direct application of the INNO-LiPA Rif.TB line-probe assay for rapid identification of Mycobacterium tuberculosis complex strains and detection of rifampin resistance in 360 smear-positive respiratory specimens from an area of high incidence of multidrug-resistant tuberculosis. 10.1128/jcm.43.9.4880-4884.2005

Antituberculosis drugs: reducing efflux=increasing activity. 10.1016/j.drudis.2017.01.002

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535

Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis. 10.1128/aac.00359-18

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase. 10.1016/j.tube.2018.08.004

Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis. 10.3389/fmicb.2018.01659

Total Synthesis of Ripostatin B and Structure-Activity Relationship Studies on Ripostatin Analogs. 10.1021/acs.joc.8b00193

Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles. 10.3389/fmicb.2019.00046

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice 10.1021/acs.jmedchem.9b00355

O contributo dos serviços de diagnóstico laboratorial para o acesso universal à saúde nos países da Comunidade de Língua Portuguesa 10.25761/ANAISIHMT.337

Katarina Mikusova

Mikusova Katarina

ORCID: 0000-0002-0100-4877

Time-adjusted Analysis Shows Weak Associations Between BCG Vaccination Policy and COVID-19 Disease Progression 10.1101/2020.05.01.20087809

Synthesis, docking study and biological evaluation of ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones as potential inhibitors of the mycobacterial galactan synthesis targeting the galactofuranosyltransferase GlfT2 10.3762/bjoc.16.152

Synthesis of the Arabinose Donor .beta.-D-Arabinofuranosyl-1-monophosphoryldecaprenol, Development of a Basic Arabinosyl-Transferase Assay, and Identification of Ethambutol as an Arabinosyl Transferase Inhibitor 10.1021/ja00153a002

Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors 10.1021/acs.jmedchem.0c00007

Development of Macozinone for TB treatment: An Update 10.3390/app10072269

Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents 10.1016/j.ejmech.2020.112773

Biosynthesis of Galactan in Mycobacterium tuberculosis as a Viable TB Drug Target? 10.3390/antibiotics9010020

New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053 10.1021/acsinfecdis.9b00388

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase 10.1021/acs.jmedchem.9b00912

Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents 10.1016/j.chembiol.2019.02.013

New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action 10.1016/j.ejmech.2018.04.017

Copper-related toxicity in replicating and dormantMycobacterium tuberculosiscaused by 1-hydroxy-5-R-pyridine-2(1H)-thiones 10.1039/c8mt00067k

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK 10.1038/s41598-018-21614-4

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535

Learning from the past for TB drug discovery in the future 10.1016/j.drudis.2016.09.025

N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis 10.1128/aac.01310-17

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors 10.1021/acsinfecdis.7b00006

Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043 10.1021/acsmedchemlett.5b00424

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis 10.1021/acs.jmedchem.5b00608

Assembling of theMycobacterium tuberculosisCell Wall Core 10.1074/jbc.m116.739227

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA 10.1038/ncomms10906

Lead selection and characterization of antitubercular compounds using the Nested Chemical Library 10.1016/j.tube.2015.02.028

The Complex Mechanism of Antimycobacterial Action of 5-Fluorouracil 10.1016/j.chembiol.2014.11.006

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG 10.1016/j.chembiol.2015.05.016

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis 10.1128/aac.00778-15

GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis 10.1128/jb.00628-15

DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization 10.1021/acschembio.5b00237

Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid – Monoacylated phosphatidylinositol dimannoside 10.1016/j.pep.2014.04.014

DprE1 - from the Discovery to the Promising Tuberculosis Drug Target 10.2174/138161282027140630122724

The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo 10.1128/jb.01346-13

AnethA-ethR-Deficient Mycobacterium bovis BCG Mutant Displays Increased Adherence to Mammalian Cells and Greater PersistenceIn Vivo, Which Correlate with Altered Mycolic Acid Composition 10.1128/iai.01332-13

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis 10.1073/pnas.1309171110

Novel synthetic (1 → 6)-α-d-mannodisaccharide substrates support processive mannosylation catalysed by the mycobacterial cell envelope enzyme fraction 10.1039/c3ra43575j

Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1 10.1021/ja211042r

A Small Multidrug Resistance-like Transporter Involved in the Arabinosylation of Arabinogalactan and Lipoarabinomannan in Mycobacteria 10.1074/jbc.m112.400986

Protein Separation and Enzyme Purification by Preparative Capillary Isotachophoresis 10.1007/s10337-012-2348-8

Synthesis of 1,2,3-Triazolo-Linked Octyl (1→6)-α-d-Oligomannosides and Their Evaluation in Mycobacterial Mannosyltransferase Assay 10.1021/bc100421g

Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster 10.4149/gpb_2011_03_239

Biosynthetic Origin of the Galactosamine Substituent of Arabinogalactan inMycobacterium tuberculosis 10.1074/jbc.m110.188110

Synthesis of alkyl and cycloalkyl α-d-mannopyranosides and derivatives thereof and their evaluation in the mycobacterial mannosyltransferase assay 10.1016/j.carres.2010.03.011

Synthetic UDP-Furanoses as Potent Inhibitors of Mycobacterial Galactan Biogenesis 10.1016/j.chembiol.2010.10.014

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance 10.1111/j.1365-2958.2010.07277.x

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis 10.1126/science.1171583

Stereoselective syntheses of heptaprenylphosphoryl β-d-arabino-and β-d-ribo-furanoses 10.1016/j.tetlet.2009.02.188

Galactosyl Transferases in Mycobacterial Cell Wall Synthesis 10.1128/jb.01326-07

Identification of promoters recognized by RNA polymerase containing Mycobacterium tuberculosis stress-response sigma factor σF 10.1007/s00203-006-0185-6

Molecular Recognition and Interfacial Catalysis by the Essential Phosphatidylinositol Mannosyltransferase PimA from Mycobacteria 10.1074/jbc.m702087200

Identification of a Novel Galactosyl Transferase Involved in Biosynthesis of the Mycobacterial Cell Wall 10.1128/jb.00489-06

Decaprenylphosphoryl Arabinofuranose, the Donor of the d-Arabinofuranosyl Residues of Mycobacterial Arabinan, Is Formed via a Two-Step Epimerization of Decaprenylphosphoryl Ribose 10.1128/jb.187.23.8020-8025.2005

Polymerization of Mycobacterial Arabinogalactan and Ligation to Peptidoglycan 10.1074/jbc.m302216200

Identification of the Required Acyltransferase Step in the Biosynthesis of the Phosphatidylinositol Mannosides ofMycobacteriumSpecies 10.1074/jbc.m303639200

Definition of the First Mannosylation Step in Phosphatidylinositol Mannoside Synthesis 10.1074/jbc.m204060200

Biosynthesis of the Galactan Component of the Mycobacterial Cell Wall 10.1074/jbc.m006875200

Interaction of Human Mannose‐Binding Protein withMycobacterium avium 10.1086/520354

Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds 10.1039/D0MD00390E

Design and Synthesis of Pyrano[3,2-b]indolones Showing Antimycobacterial Activity 10.1021/acsinfecdis.0c00622

An ABC transporter Wzm-Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria. 10.1073/pnas.2023663118

Digby Warner

Warner Digby

ORCID: 0000-0002-4146-0930

Antimycobacterial, cytotoxic, and antioxidant activities of abietane diterpenoids isolated from plectranthus madagascariensis 10.3390/plants10010175

Easy-to-access quinolone derivatives exhibiting antibacterial and anti-parasitic activities 10.3390/molecules26041141

Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosis 10.1093/jac/dkt364

Detection of Mycobacterium tuberculosis bacilli in bio-aerosols from untreated TB patients [version 1; referees: awaiting peer review] 10.12688/gatesopenres.12758.1

Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery 10.1128/AAC.01178-16

Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes 10.1039/C7DT01952A

Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c 10.1128/AAC.01338-17

Detection of Mycobacterium tuberculosis bacilli in bio-aerosols from untreated TB patients [version 2; referees: 2 approved, 1 approved with reservations] 10.12688/gatesopenres.12758.2

Drug permeation and metabolism in Mycobacterium tuberculosis: Prioritising local exposure as essential criterion in new TB drug development 10.1002/iub.1866

CRISPRi-Seq for the Identification and Characterisation of Essential Mycobacterial Genes and Transcriptional Units 10.1101/358275

Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents 10.20944/preprints201709.0070.v1

Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity 10.3390/molecules23082038

Death of Mycobacterium tuberculosis by l-arginine starvation 10.1073/pnas.1813587115

Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation 10.1039/C8MD00480C

New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis 10.3390/molecules24091740

Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications 10.1183/13993003.02302-2018

Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives 10.1111/cbdd.13534

Targeting DNA replication and repair for the development of novel therapeutics against tuberculosis 10.3389/fmolb.2017.00075

Erratum: Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization (Bioorg. Med. Chem. (2015) 23 (7240-7250)) 10.1016/j.bmc.2015.12.015

Diversity and disease pathogenesis in mycobacterium tuberculosis 10.1016/j.tim.2014.10.005

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization 10.1021/acsinfecdis.7b00275

Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery 10.1016/j.bmc.2014.06.012

Mono- and polynuclear ferrocenylthiosemicarbazones: Synthesis, characterisation and antimicrobial evaluation 10.1016/j.jorganchem.2016.06.032

Nucleotide metabolism and DNA replication 10.1128/microbiolspec.MGM2-0001-2013

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A novel antimycobacterial class targeting mycobacterial respiration 10.1021/acs.jmedchem.5b01542

Targeted gene knockout and essentiality testing by homologous recombination 10.1007/978-1-4939-2450-9_8

Synthesis and biological evaluation of (E)-cinnamic acid, (E)-2-styrylthiazole and (E)-2-[2-(naphthalen-1-yl)vinyl]thiazole derivatives 10.24820/ark.5550190.p009.905

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies 10.1021/acs.jmedchem.7b01347

DNA replication fidelity in the mycobacterium tuberculosis complex 10.1007/978-3-319-64371-7_13

DNA Replication in Mycobacterium tuberculosis 10.1128/microbiolspec.TBTB2-0027-2016

Mycobacterium tuberculosis metabolism 10.1101/cshperspect.a021121

The complex mechanism of antimycobacterial action of 5-fluorouracil 10.1016/j.chembiol.2014.11.006

Editorial overview: Tuberculosis, malaria and schistosomiasis; understanding resistance and development of new drugs 10.1016/j.coph.2018.09.002

The Influence of HIV on the Evolution of Mycobacterium tuberculosis 10.1093/molbev/msx107

Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones 10.1016/j.bmcl.2019.05.001

Synthesis and biological evaluation of (E)-cinnamic acid, (E)-2-styrylthiazole and (E)-2-[2-(naphthalen-1-yl)vinyl]thiazole derivatives 10.3998/ark.5550190.p009.905

Expanding the anti-TB arsenal 10.1126/science.aaw5224

Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagar™STEC media 10.1016/j.jprot.2017.09.003

Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB 10.1002/cmdc.201900289

Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis 10.1021/acsinfecdis.6b00111

Genome-wide transposon mutagenesis in Mycobacterium tuberculosis and Mycobacterium smegmatis 10.1007/978-1-4939-6472-7_21

Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization 10.1016/j.bmc.2015.10.021

Beyond the lab: Eh!woza and knowing tuberculosis 10.1136/medhum-2018-011479

Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights 10.1016/j.ejmech.2019.06.069

Real-time investigation of tuberculosis transmission: Developing the respiratory aerosol sampling chamber (RASC) 10.1371/journal.pone.0146658

Effective visualization of tuberculosis three-drug assays: A design study 10.1145/2987491.2987501

Defining a diagnostic gene signature for tuberculosis 10.1016/S2213-2600(16)00063-1

Versatility of 7-substituted coumarin molecules as antimycobacterial agents, neuronal enzyme inhibitors and neuroprotective agents 10.3390/molecules22101644

Synthesis, characterization and antimicrobial evaluation of mono- and polynuclear ferrocenyl-derived amino and imino complexes 10.1016/j.jorganchem.2016.02.033

Synthesis and biological screening of diethyl [N-(thiazol-2-yl)carbamoyl]methylphosphonates 10.24820/ark.5550190.p010.534

The inosine monophosphate dehydrogenase, GuaB2, is a vulnerable new bactericidal drug target for tuberculosis 10.1021/acsinfecdis.6b00102

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535

In Vitro Efficacies, ADME, and Pharmacokinetic Properties of Phenoxazine Derivatives Active against Mycobacterium tuberculosis 10.1128/AAC.01010-19

Synthesis and antimycobacterial activity of disubstituted benzyltriazoles 10.1007/s00044-019-02458-7

Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant Mycobacterium tuberculosis 10.1101/860288

Arrayed CRISPRi and Quantitative Imaging Describe the Morphotypic Landscape of Essential Mycobacterial Genes 10.1101/2020.03.20.000372

Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues 10.1016/j.bioorg.2020.103587

Novel South African Rare Actinomycete Kribbella speibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners 10.3390/molecules25132979

Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes 10.1016/j.ejmech.2020.112694

Synthesis and in vitro antimycobacterial and antileishmanial activities of hydroquinone-triazole hybrids https://doi.org/10.1007/s00044-020-02553-0

Novel approach to estimate tuberculosis transmission in primary care clinics in sub-Saharan Africa: protocol of a prospective study 10.1136/bmjopen-2019-036214

Sensitivity optimisation of tuberculosis bioaerosol sampling 10.1371/journal.pone.0238193

Bioaerosol sampling of patients with suspected pulmonary tuberculosis: a study protocol 10.1186/s12879-020-05278-y

Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes 10.7554/eLife.60083

De novo cobalamin biosynthesis, transport and assimilation and cobalamin-mediated regulation of methionine biosynthesis in Mycobacterium smegmatis 10.1101/2020.11.04.369181

Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds 10.3390/ijms21228854

Synthesis and antimicrobial study of organoiridium amido-sulfadoxine complexes 10.1016/j.ica.2020.120175

Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis 10.3389/fcimb.2020.582416

De Novo Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in Mycobacterium smegmatis 10.1128/JB.00620-20

Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents doi.org/10.1016/j.bmcl.2019.126911

Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols 10.1371/journal.ppat.1009262

Developing Synergistic Drug Combinations To Restore Antibiotic Sensitivity in Drug-Resistant Mycobacterium tuberculosis 10.1128/AAC.02554-20

Translating genomics research into control of tuberculosis: lessons learned and future prospects 10.1186/s13059-014-0514-z

Physiology of Mycobacterium tuberculosis 10.1002/9783527611614.ch3

The impact of drug resistance onMycobacterium tuberculosisphysiology: what can we learn from rifampicin? 10.1038/emi.2014.17

Shortening Treatment for Tuberculosis Back to Basics 10.1056/nejme1410977

Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolites 10.1039/c3md00387f

Vitamin B12metabolism inMycobacterium tuberculosis 10.2217/fmb.13.113

A vitamin B 12 transporter in Mycobacterium tuberculosis 10.1098/rsob.120175

DNA Metabolism in Mycobacterial Pathogenesis 10.1007/82_2013_328

Detection and treatment of subclinical tuberculosis 10.1016/j.tube.2012.06.004

Tuberculosis Drug Discovery: Target Identification and Validation 10.1007/978-3-642-28175-4_3

Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis 10.1073/pnas.1002614107

The role of DNA repair in M. tuberculosis pathogenesis 10.1016/j.ddmec.2010.08.002

A Riboswitch Regulates Expression of the Coenzyme B12-Independent Methionine Synthase in Mycobacterium tuberculosis: Implications for Differential Methionine Synthase Function in Strains H37Rv and CDC1551 10.1128/jb.00040-07

Tuberculosis Chemotherapy: the Influence of Bacillary Stress and Damage Response Pathways on Drug Efficacy 10.1128/cmr.00060-05

Mechanisms of stationary-phase mutagenesis in bacteria and their relevance to antibiotic resistance 10.1017/cbo9780511546242.006

Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria 10.1101/2021.05.01.442251

Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis 10.1155/2021/5583342

Arylquinolinecarboxamides: Synthesis, in vitro and in silico studies against Mycobacterium tuberculosis 10.1002/jhet.4340

Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B 10.3762/bjoc.17.156

Kai Johnsson

Johnsson Kai

ORCID: 0000-0002-8002-1981

https://www.mr.mpg.de/13943495/chemical_biology

A synergistic strategy to develop photostable and bright dyes with long Stokes shift for super-resolution microscopy 10.21203/rs.3.rs-885436/v1

Fluorescence microscopy: strategic blinking. 10.1038/nchem.2020

Fluorogenic probes for live-cell imaging of the cytoskeleton. 10.1038/nmeth.2972

Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring. 10.1038/nchembio.1554

A fluorogenic probe for SNAP-tagged plasma membrane proteins based on the solvatochromic molecule Nile Red. 10.1021/cb400819c

Sensing acetylcholine and anticholinesterase compounds. 10.1002/anie.201307754

Yeast three-hybrid screening for identifying anti-tuberculosis drug targets. 10.1002/cbic.201300472

Computational design of ligand-binding proteins with high affinity and selectivity. 10.1038/nature12443

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. 10.1073/pnas.1309171110

Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs. 10.1126/science.1232972

Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex. 10.1016/j.cub.2012.12.030

A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. 10.1038/nchem.1546

Investigating endocytic pathways to the endoplasmic reticulum and to the cytosol using SNAP-trap. 10.1111/tra.12018

Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation. 10.1016/j.nbt.2012.05.005

Substrates for improved live-cell fluorescence labeling of SNAP-tag. 10.2174/1381612811319300011

A fluorescent sensor for GABA and synthetic GABA(B) receptor ligands. 10.1021/ja306320s

Liver-specific ablation of Kruppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma. 10.1002/hep.25767

WhiB5, a transcriptional regulator that contributes to Mycobacterium tuberculosis virulence and reactivation. 10.1128/IAI.06328-11

A semisynthetic fluorescent sensor protein for glutamate. 10.1021/ja3002277

A caged, localizable rhodamine derivative for superresolution microscopy. 10.1021/cb2002889

Directed evolution of the suicide protein O⁶-alkylguanine-DNA alkyltransferase for increased reactivity results in an alkylated protein with exceptional stability. 10.1021/bi2016537

Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5). 10.1007/978-1-4614-1566-4_39

Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1. 10.1021/ja211042r

Exploiting ligand-protein conjugates to monitor ligand-receptor interactions. 10.1371/journal.pone.0037598

Switchable fluorophores for protein labeling in living cells. 10.1016/j.cbpa.2011.10.015

Semisynthesis of fluorescent metabolite sensors on cell surfaces. 10.1021/ja206915m

Development of SNAP-tag fluorogenic probes for wash-free fluorescence imaging. 10.1002/cbic.201100173

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis. 10.1038/nchembio.557

Measuring in vivo protein half-life. 10.1016/j.chembiol.2011.03.014

Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method. 10.1021/ja200225m

Labelling cell structures and tracking cell lineage in zebrafish using SNAP-tag. 10.1002/dvdy.22574

Reflections on chemical biology. 10.1021/cb100405m

NCCR Chemical Biology: Interdisciplinary Research Excellence, Outreach, Education, and New Tools for Switzerland. 10.2533/chimia.2011.832

Visualizing biochemical activities in living cells through chemistry. 10.2533/chimia.2011.868

Chemical biology approaches to membrane homeostasis and function. 10.2533/chimia.2011.849

How to obtain labeled proteins and what to do with them. 10.1016/j.copbio.2010.09.011

Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis. 10.1021/ja106357w

Fura-2FF-based calcium indicator for protein labeling. 10.1039/c000158a

Localizable and highly sensitive calcium indicator based on a BODIPY fluorophore. 10.1021/ac100741t

Targeted photoswitchable probe for nanoscopy of biological structures. 10.1002/cbic.201000189

Phosphopantetheinyl transferase-catalyzed formation of bioactive hydrogels for tissue engineering. 10.1021/ja9098164

Photoactivatable and photoconvertible fluorescent probes for protein labeling. 10.1021/cb1000229

Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5). 10.1016/j.bpj.2009.10.006

Using peptide loop insertion mutagenesis for the evolution of proteins. 10.1007/978-1-60761-652-8_16

Selective cross-linking of interacting proteins using self-labeling tags. 10.1021/ja907818q

Semisynthetic fluorescent sensor proteins based on self-labeling protein tags. 10.1021/ja900149e

Indo-1 derivatives for local calcium sensing. 10.1021/cb800258g

Visualizing biochemical activities in living cells. 10.1038/nchembio0209-63

Regulation of glutamate metabolism by protein kinases in mycobacteria. 10.1111/j.1365-2958.2008.06489.x

Subunit-specific surface mobility of differentially labeled AMPA receptor subunits. 10.1016/j.ejcb.2008.02.014

A designed protein for the specific and covalent heteroconjugation of biomolecules. 10.1021/bc800268j

Investigative reporters. 10.1021/cb800134q

A split-protein sensor for studying protein-protein interaction in mycobacteria. 10.1016/j.mimet.2008.02.008

An engineered protein tag for multiprotein labeling in living cells. 10.1016/j.chembiol.2008.01.007

Caged substrates for protein labeling and immobilization. 10.1002/cbic.200700472

A covalent chemical genotype-phenotype linkage for in vitro protein evolution. 10.1002/cbic.200700459

Chemical probes shed light on protein function. 10.1016/j.sbi.2007.07.005

Inducing and sensing protein--protein interactions in living cells by selective cross-linking. 10.1002/anie.200700408

Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling. 10.1093/protein/gzl014

Post-translational covalent labeling reveals heterogeneous mobility of individual G protein-coupled receptors in living cells. 10.1002/cbic.200500477

Chimeric streptavidins with reduced valencies. 10.1038/nmeth0406-247

Covalent labeling of cell-surface proteins for in-vivo FRET studies. 10.1016/j.febslet.2006.02.007

FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells. 10.1073/pnas.0507686103

Protein function microarrays based on self-immobilizing and self-labeling fusion proteins. 10.1002/cbic.200500278

The laboratory in a droplet. 10.1016/j.chembiol.2005.11.006

Multicolor imaging of cell surface proteins. 10.1021/ja0533850

Adding value to fusion proteins through covalent labelling. 10.1016/j.copbio.2005.06.001

Engineering substrate specificity of O6-alkylguanine-DNA alkyltransferase for specific protein labeling in living cells. 10.1002/cbic.200400431

Fast directed evolution of non-immunoglobulin proteins by somatic hypermutation in immune cells. 10.1002/cbic.200500011

Protein chemistry on the surface of living cells. 10.1002/cbic.200400290

Protein-functionalized polymer brushes. 10.1021/bm050016n

Specific labeling of cell surface proteins with chemically diverse compounds. 10.1021/ja048396s

Labeling of fusion proteins with synthetic fluorophores in live cells. 10.1073/pnas.0401923101

Synthesis and characterization of bifunctional probes for the specific labeling of fusion proteins. 10.1016/j.bmcl.2004.03.078

Labeling of fusion proteins of O6-alkylguanine-DNA alkyltransferase with small molecules in vivo and in vitro. 10.1016/j.ymeth.2003.10.007

Induced protein dimerization in vivo through covalent labeling. 10.1021/ja037883p

DNA repair protein O6-methylguanine-DNA methyltransferase in testis and testicular tumors as determined by a novel nonradioactive assay. 10.1016/S0003-2697(03)00432-9

A fusion of disciplines: chemical approaches to exploit fusion proteins for functional genomics. 10.1002/cbic.200200603

Covalent and selective immobilization of fusion proteins. 10.1021/ja034145s

Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo. 10.1016/S1074-5521(03)00068-1

A general method for the covalent labeling of fusion proteins with small molecules in vivo. 10.1038/nbt765

Examining reactivity and specificity of cytochrome c peroxidase by using combinatorial mutagenesis. 10.1002/1439-7633(20021104)3:11<1097::AID-CBIC1097>3.0.CO;2-4

Towards the generation of artificial O6-alkylguanine-DNA alkyltransferases: in vitro selection of antibodies with reactive cysteine residues. 10.1002/1439-7633(20020603)3:6<573::AID-CBIC573>3.0.CO;2-F

Inter- and intramolecular domain interactions of the catalase-peroxidase KatG from M. tuberculosis. 10.1016/S0014-5793(01)03179-9

Changing the substrate specificity of cytochrome c peroxidase using directed evolution. 10.1006/bbrc.2001.5366

Synthesis and applications of chemical probes for human O6-alkylguanine-DNA alkyltransferase. 10.1002/1439-7633(20010401)2:4<285::AID-CBIC285>3.3.CO;2-E

Directed molecular evolution of cytochrome c peroxidase. 10.1021/bi001121e

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