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LppM impact on the colonization of macrophages by Mycobacterium tuberculosis

Deboosere, N. Iantomasi, R. Queval, C. J. Song, O. R. Deloison, G. Jouny, S. Debrie, A. S. Chamaillard, M. Nigou, J. Cohen-Gonsaud, M. Locht, C. Brodin, P. Veyron-Churlet, R.

Cellular Microbiology, 2017

https://doi.org/10.1111/cmi.12619

Camille Locht

Locht Camille

ORCID: 0000-0001-7295-7336

HBHA-Induced Polycytotoxic CD4+ T Lymphocytes Are Associated with the Control of Mycobacterium tuberculosis Infection in Humans 10.4049/jimmunol.1800840

Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS 10.1371/journal.pone.0204861

Non-specific Effects of Live Attenuated Pertussis Vaccine Against Heterologous Infectious and Inflammatory Diseases 10.3389/fimmu.2018.02872

IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine 10.1038/s41385-018-0073-9

Rv0613c/MSMEG_1285 Interacts with HBHA and Mediates Its Proper Cell-Surface Exposure in Mycobacteria 10.3390/ijms19061673

Tuberculin skin test reaction is related to memory, but not naive CD4+ T cell responses to mycobacterial stimuli in BCG-vaccinated young adults 10.1016/j.vaccine.2018.05.068

Diversion of complement-mediated killing by Bordetella 10.1016/j.micinf.2018.02.002

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development 10.3389/fimmu.2017.01203

Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis 10.1371/journal.pone.0176396

Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258

In vivo imaging of bacterial colonization of the lower respiratory tract in a baboon model of Bordetella pertussis infection and transmission 10.1038/s41598-018-30896-7

Primary transcriptome analysis reveals importance of IS elements for the shaping of the transcriptional landscape of Bordetella pertussis 10.1080/15476286.2018.1462655

Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor 10.1038/s41426-018-0039-8

Construction and evaluation of Bordetella pertussis live attenuated vaccine strain BPZE1 producing Fim3 10.1016/j.vaccine.2018.02.017

Will we have new pertussis vaccines? 10.1016/j.vaccine.2017.11.055

Assessing the reactogenicity of Tdap vaccine administered during pregnancy and antibodies to Bordetella pertussis antigens in maternal and cord sera of Thai women 10.1016/j.vaccine.2018.01.059

Conformational Changes of an Interdomain Linker Mediate Mechanical Signal Transmission in Sensor Kinase BvgS 10.1128/JB.00114-17

Coiled-Coil Antagonism Regulates Activity of Venus Flytrap-Domain-Containing Sensor Kinases of the BvgS Family 10.1128/mBio.02052-17

The Role of Mucosal Immunity in Pertussis 10.3389/fimmu.2018.03068

Live Attenuated Pertussis Vaccine BPZE1 Protects Baboons Against Bordetella pertussis Disease and Infection 10.1093/infdis/jix254

BCG and protection against inflammatory and auto-immune diseases 10.1080/14760584.2017.1333906

Age-Stratified T Cell Responses in Children Infected with Mycobacterium tuberculosis 10.3389/fimmu.2017.01059

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006

Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development 10.1128/CVI.00388-16

Erratum for Carbonetti et al., "Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development" 10.1128/CVI.00071-17

Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis 10.15252/emmm.201606330

Live pertussis vaccines: will they protect against carriage and spread of pertussis? 10.1016/j.cmi.2016.05.029

The multifaceted RisA regulon of Bordetella pertussis 10.1038/srep32774

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619

Added Value of Long-Term Cytokine Release Assays to Detect Mycobacterium tuberculosis Infection in HIV-Infected Subjects in Uganda 10.1097/QAI.0000000000000980

[Tuberculosis, a story still relevant] 10.1051/medsci/20163206001

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297

Pertussis: Where did we go wrong and what can we do about it? 10.1016/j.jinf.2016.04.020

Pertussis: acellular, whole-cell, new vaccines, what to choose? 10.1586/14760584.2016.1161511

Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella 10.1128/mBio.02089-15

Reciprocal interference of maternal and infant immunization in protection against pertussis 10.1016/j.vaccine.2016.01.011

Signal transduction by BvgS sensor kinase. Binding of modulator nicotinate affects the conformation and dynamics of the entire periplasmic moiety 10.1074/jbc.A115.655720

Integrating knowledge of Mycobacterium tuberculosis pathogenesis for the design of better vaccines 10.1586/14760584.2015.1102638

Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults 10.1155/2015/359153

Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome 10.1371/journal.pone.0133924

Dynamic interplay of membrane-proximal POTRA domain and conserved loop L6 in Omp85 transporter FhaC 10.1111/mmi.13137

Signal Transduction by BvgS Sensor Kinase: BINDING OF MODULATOR NICOTINATE AFFECTS THE CONFORMATION AND DYNAMICS OF THE ENTIRE PERIPLASMIC MOIETY 10.1074/jbc.M115.655720

Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS 10.1371/journal.ppat.1004700

Investigating pertussis toxin and its impact on vaccination 10.2217/fmb.14.123

Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: comparison with the tuberculin skin test and the QuantiFERON-TB Gold In-tube 10.1186/s12879-015-0796-0

Early cellular immune response to a new candidate mycobacterial vaccine antigen in childhood tuberculosis 10.1016/j.vaccine.2014.12.011

Unconventional, adenosine-producing suppressor T cells induced by dendritic cells exposed to BPZE1 pertussis vaccine 10.1189/jlb.3a0315-101r

Translocation path of a substrate protein through its Omp85 transporter 10.1038/ncomms6271

Antigen-specific interferon-gamma responses and innate cytokine balance in TB-IRIS 10.1371/journal.pone.0113101

HBHA vaccination may require both Th1 and Th17 immune responses to protect mice against tuberculosis 10.1016/j.vaccine.2014.09.024

Toward Understanding the Essence of Post-Translational Modifications for the Mycobacterium tuberculosis Immunoproteome 10.3389/fimmu.2014.00361

Live attenuated B. pertussis BPZE1 rescues the immune functions of Respiratory Syncytial virus infected human dendritic cells by promoting Th1/Th17 responses 10.1371/journal.pone.0100166

Live attenuated vaccines against pertussis 10.1586/14760584.2014.942222

Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin 10.1016/j.micinf.2014.04.003

Conformational dynamics of protein transporter FhaC: large-scale motions of plug helix 10.1111/mmi.12585

B-cell responses after intranasal vaccination with the novel attenuated Bordetella pertussis vaccine strain BPZE1 in a randomized phase I clinical trial 10.1016/j.vaccine.2014.04.048

Possible options for new pertussis vaccines 10.1093/infdis/jit531

A phase I clinical study of a live attenuated Bordetella pertussis vaccine--BPZE1; a single centre, double-blind, placebo-controlled, dose-escalating study of BPZE1 given intranasally to healthy adult male volunteers 10.1371/journal.pone.0083449

Mucosal delivery of antigen-coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice 10.1002/eji.201343887

Pertussis toxin improves immune responses to a combined pneumococcal antigen and leads to enhanced protection against Streptococcus pneumoniae 10.1128/CVI.00134-14

Heterologous prime-boost immunization with live attenuated B. pertussis BPZE1 followed by acellular pertussis vaccine in mice 10.1016/j.vaccine.2014.06.019

Key role of effector memory CD4+ T lymphocytes in a short-incubation heparin-binding hemagglutinin gamma interferon release assay for the detection of latent tuberculosis 10.1128/CVI.00651-13

LPS-binding protein and IL-6 mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients 10.1371/journal.pone.0081856

Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism 10.1164/rccm.201307-1227OC

Protective role of adenylate cyclase in the context of a live pertussis vaccine candidate 10.1016/j.micinf.2013.10.002

Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination 10.1016/j.vaccine.2013.10.056

Heparin-binding haemagglutinin, a new tool for the detection of latent Mycobacterium tuberculosis infection in hemodialysis patients 10.1371/journal.pone.0071088

Novel feature of Mycobacterium avium subsp. paratuberculosis, highlighted by characterization of the heparin-binding hemagglutinin adhesin 10.1128/JB.00671-13

Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission 10.1186/1471-2180-13-172

Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome 10.1097/qad.0b013e328361648b

The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome 10.1016/j.imbio.2013.07.004

Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e 10.1371/journal.pone.0059198

Purification of native HBHA from Mycobacterium avium subsp. paratuberculosis 10.1186/1756-0500-6-55

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis 10.1038/ng.2517

Persistence at one year of age of antigen-induced cellular immune responses in preterm infants vaccinated against whooping cough: comparison of three different vaccines and effect of a booster dose 10.1016/j.vaccine.2013.02.004

Low prevalence of vitamin D deficiency in Ugandan HIV-infected patients with and without tuberculosis 10.5588/ijtld.11.0146

Broad heparin-binding haemagglutinin-specific cytokine and chemokine response in infants following Mycobacterium bovis BCG vaccination 10.1002/eji.201142297

Risk stratification of latent tuberculosis defined by combined interferon gamma release assays 10.1371/journal.pone.0043285

Attenuated Bordetella pertussis BPZE1 protects against allergic airway inflammation and contact dermatitis in mouse models 10.1111/j.1398-9995.2012.02884.x

Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice 10.1016/j.vaccine.2012.07.005

New pertussis vaccination approaches: en route to protect newborns? 10.1111/j.1574-695x.2012.00988.x

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis 10.1021/jm300377g

Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis 10.1371/journal.pone.0032421

Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection 10.3851/imp2108

Both CD4⁺ and CD8⁺ lymphocytes participate in the IFN-γ response to filamentous hemagglutinin from Bordetella pertussis in infants, children, and adults 10.1155/2012/795958

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands 10.1093/nar/gkr1113

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors 10.1021/jm200825u

The ins and outs of pertussis toxin 10.1111/j.1742-4658.2011.08237.x

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Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy 10.1097/qai.0b013e3182255dc2

[New antituberculosis vaccines] 10.1016/j.arcped.2011.05.003

Development of live attenuated Bordetella pertussis strains expressing the universal influenza vaccine candidate M2e 10.1016/j.vaccine.2011.05.052

Recombinant HBHA boosting effect on BCG-induced immunity against Mycobacterium tuberculosis infection 10.1155/2011/730702

Substrate recognition by the POTRA domains of TpsB transporter FhaC 10.1111/j.1365-2958.2011.07680.x

Membrane-associated DegP in Bordetella chaperones a repeat-rich secretory protein 10.1111/j.1365-2958.2011.07672.x

Detection of small RNAs in Bordetella pertussis and identification of a novel repeated genetic element 10.1186/1471-2164-12-207

The forest behind the tree: phylogenetic exploration of a dominant Mycobacterium tuberculosis strain lineage from a high tuberculosis burden country 10.1371/journal.pone.0018256

Attenuated Bordetella pertussis vaccine candidate BPZE1 promotes human dendritic cell CCL21-induced migration and drives a Th1/Th17 response 10.4049/jimmunol.1003765

Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors 10.1021/jm200076a

Characterization of the Mycobacterium avium subsp. paratuberculosis laminin-binding/histone-like protein (Lbp/Hlp) which reacts with sera from patients with Crohn's disease 10.1016/j.micinf.2011.02.002

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Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator 10.1021/cb100177g

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Long-term immunity against pertussis induced by a single nasal administration of live attenuated B. pertussis BPZE1 10.1016/j.vaccine.2010.08.017

Report of the 2nd "French Clinical Vaccinology Meeting Jean-Gerard Guillet": immunization and respiratory diseases 10.1016/j.vaccine.2010.07.038

Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism 10.1073/pnas.1006267107

Boosting BCG to protect against TB 10.1586/ers.10.25

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Boosting with mycobacterial heparin-binding haemagglutinin enhances protection of Mycobacterium bovis BCG-vaccinated newborn mice against M. tuberculosis 10.1016/j.vaccine.2010.04.062

T- and B-cell-mediated protection induced by novel, live attenuated pertussis vaccine in mice. Cross protection against parapertussis 10.1371/journal.pone.0010178

Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model 10.1111/j.1365-2222.2010.03459.x

Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans 10.1164/rccm.201001-0083oc

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Cellular immune responses of preterm infants after vaccination with whole-cell or acellular pertussis vaccines 10.1128/CVI.00328-09

Correction: Molecular Evolution of the Two-Component System BvgAS Involved in Virulence Regulation in Bordetella 10.1371/annotation/ae7f86ff-0aca-4411-aed3-3eeea9303abb

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Priscille Brodin

Brodin Priscille

ORCID: 0000-0003-0991-7344

Email: priscille.brodin@inserm.fr

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Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z

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LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619

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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j

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Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization 10.1016/j.str.2016.07.009

Mycolactone The amazing analgesic mycobacterial toxin 10.1051/medsci/20163202007

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297

2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163

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Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays 10.1007/978-1-4939-2450-9_24

A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening 10.3791/51114

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/jm500422b

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Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779

Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u

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Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125

Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025

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The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4

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Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101

Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129

A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening 10.1002/cyto.a.20627

Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360

Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation 10.1074/mcp.RA119.001316

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378

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Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258

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A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J

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Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g

Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38

Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82

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Anne-Sophie Debrie

Debrie Anne-Sophie

ORCID: 0000-0003-0570-4413

Construction and evaluation of Bordetella pertussis live attenuated vaccine strain BPZE1 producing Fim3. 10.1016/j.vaccine.2018.02.017

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STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. 10.1111/cmi.12619

HBHA vaccination may require both Th1 and Th17 immune responses to protect mice against tuberculosis. 10.1016/j.vaccine.2014.09.024

Heterologous prime-boost immunization with live attenuated B. pertussis BPZE1 followed by acellular pertussis vaccine in mice. 10.1016/j.vaccine.2014.06.019

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Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin. 10.1016/j.micinf.2014.04.003

Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e. 10.1371/journal.pone.0059198

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. 10.1038/ng.2517

Mycobacterial laminin-binding histone-like protein mediates collagen-dependent cytoadherence. 10.1590/s0074-02762012000900025

Seroprevalence of pertussis in Senegal: a prospective study. 10.1371/journal.pone.0048684

Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice. 10.1016/j.vaccine.2012.07.005

Attenuated Bordetella pertussis vaccine candidate BPZE1 promotes human dendritic cell CCL21-induced migration and drives a Th1/Th17 response. 10.4049/jimmunol.1003765

Chips from chips: application to the study of antibody responses to methylated proteins. 10.1021/pr100707t

Long-term immunity against pertussis induced by a single nasal administration of live attenuated B. pertussis BPZE1. 10.1016/j.vaccine.2010.08.017

Boosting with mycobacterial heparin-binding haemagglutinin enhances protection of Mycobacterium bovis BCG-vaccinated newborn mice against M. tuberculosis. 10.1016/j.vaccine.2010.04.062

Dose response of attenuated Bordetella pertussis BPZE1-induced protection in mice. 10.1128/cvi.00322-09

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Molecular evolution of the two-component system BvgAS involved in virulence regulation in Bordetella. 10.1371/journal.pone.0006996

Cytokine and antibody profiles in 1-year-old children vaccinated with either acellular or whole-cell pertussis vaccine during infancy. 10.1016/j.vaccine.2009.07.075

Subcutaneous boosting with heparin binding haemagglutinin increases BCG-induced protection against tuberculosis. 10.1016/j.micinf.2009.07.005

Heparin-binding hemagglutinin (HBHA) of Mycobacterium leprae is expressed during infection and enhances bacterial adherence to epithelial cells. 10.1111/j.1574-6968.2009.01488.x

Genetic stability of the live attenuated Bordetella pertussis vaccine candidate BPZE1. 10.1016/j.vaccine.2008.08.018

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The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis. 10.1128/iai.72.12.6799-6805.2004

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Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses. 10.4049/jimmunol.170.3.1504

Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis. 10.1073/pnas.162246899

Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin. 10.1099/00221287-148-4-1193

Nathalie deboosere

deboosere Nathalie

ORCID: 0000-0002-2873-5485

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 10.1016/j.celrep.2017.08.101

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. 10.3390/toxins9070227

Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. 10.1021/acschembio.7b00091

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. 10.1111/cmi.12619

A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114

Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces. 10.1016/j.fm.2012.04.007

Viral elution and concentration method for detection of influenza A viruses in mud by real-time RT-PCR. 10.1016/j.jviromet.2011.10.013

Comparison of chlorine and peroxyacetic-based disinfectant to inactivate Feline calicivirus, Murine norovirus and Hepatitis A virus on lettuce. 10.1016/j.ijfoodmicro.2011.08.011

Direct detection of highly pathogenic avian influenza A/H5N1 virus from mud specimens. 10.1016/j.jviromet.2011.06.002

Development and validation of a concentration method for the detection of influenza a viruses from large volumes of surface water. 10.1128/aem.02484-10

A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries. 10.1016/j.fm.2010.05.018

Assessment of the removal and inactivation of influenza viruses H5N1 and H1N1 by drinking water treatment. 10.1016/j.watres.2010.01.013

Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables. 10.1016/j.ijfoodmicro.2005.11.007

Modelling effect of physical and chemical parameters on heat inactivation kinetics of hepatitis A virus in a fruit model system. 10.1016/j.ijfoodmicro.2003.10.015

Host-pathogen systems for early drug discovery against tuberculosis. 10.1016/j.mib.2017.11.017

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids. 10.1073/pnas.1707840114

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. 10.1038/s41598-017-11843-4

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages. 10.1016/j.chom.2017.07.020

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-017-05453-3

Host-directed therapies offer novel opportunities for the fight against tuberculosis. 10.1016/j.drudis.2017.05.005

Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs. 10.1016/j.ijpharm.2017.05.030

Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis. 10.3389/fcimb.2017.00137

Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections. 10.2217/nnm-2016-0364

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. 10.1126/science.aag1006

How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 10.1007/s00401-016-1652-z

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535

Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization. 10.1016/j.str.2016.07.009

Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro. 10.1007/s00705-016-2771-5

[Mycolactone: the amazing analgesic mycobacterial toxin]. 10.1051/medsci/20163202007

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. 10.1039/c5ob02630j

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action. 10.1128/jvi.01473-15

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system. 10.1016/j.vaccine.2015.03.083

Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo. 10.1371/journal.ppat.1004650

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Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays. 10.1007/978-1-4939-2450-9_24

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1. 10.1021/cb5007163

High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis. 10.1128/aac.03705-14

Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways. 10.1016/j.cell.2014.04.040

Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches. 10.1021/jm500422b

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262

The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence. 10.1371/journal.pone.0047573

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors. 10.1021/jm200825u

A novel specific edge effect correction method for RNA interference screenings. 10.1093/bioinformatics/btr648

Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis. 10.1371/journal.pone.0026675

High-content screening in infectious diseases. 10.1016/j.cbpa.2011.05.023

Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors. 10.1021/jm200076a

Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38

High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. 10.1371/journal.ppat.1001100

High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery. 10.4155/fmc.10.223

Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ. 10.1099/mic.0.038133-0

High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. 10.1371/journal.ppat.1000645

Systematic genetic nomenclature for type VII secretion systems. 10.1371/journal.ppat.1000507

Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. 10.1016/j.biomaterials.2009.09.044

Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. 10.1126/science.1171583

Automated high-throughput siRNA transfection in raw 264.7 macrophages: a case study for optimization procedure. 10.1177/1087057108328762

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. 10.1371/journal.ppat.0040033

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. 10.1128/jb.00469-07

[Aquatic insects and transmission of Mycobacterium ulcerans]. 10.1051/medsci/20072367572

Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis. 10.1371/journal.ppat.0030062

Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva. 10.1371/journal.pmed.0040064

Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues. 10.1016/j.bmc.2006.12.009

Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence. 10.1128/jb.00631-06

High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection. 10.1128/iai.02086-05

Benzofuro[3,2-f][1]benzopyrans: a new class of antitubercular agents. 10.1016/j.bmc.2006.03.033

An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis. 10.1128/iai.74.4.2128-2137.2006

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. 10.1128/iai.74.1.88-98.2006

Tuberculosis: from genome to vaccine. 10.1586/14760584.4.4.541

Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics. 10.1099/mic.0.27799-0

Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. 10.1016/j.tube.2004.09.009

ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007

Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens. 10.1086/421468

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6. 10.1128/iai.72.4.2170-2176.2004

CD8+-T-cell responses of Mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family. 10.1128/iai.71.12.7173-7177.2003

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. 10.1038/nm859

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. 10.1046/j.1365-2958.2002.03237.x

Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. 10.1128/iai.70.10.5568-5578.2002

Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides. 10.1021/bi015732y

IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551

Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483

Mathias Chamaillard

Chamaillard Mathias

ORCID: 0000-0002-0243-9717

http://phycell.univ-lille.fr/team-2-inflammasome-and-ion-channels

CCL17 Production by Dendritic Cells Is Required for NOD1-mediated Exacerbation of Allergic Asthma 10.1164/rccm.201310-1827OC

Pancreatitis-Associated Protein Does Not Predict Disease Relapse in Inflammatory Bowel Disease Patients 10.1371/journal.pone.0084957

Pseudomonas aeruginosa Type-3 Secretion System Dampens Host Defense by Exploiting the NLRC4-coupled Inflammasome 10.1164/rccm.201307-1358OC

Dysbiosis, a new medical concept 10.1051/medsci/2013296011

Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin 10.1073/pnas.1218446110

Looking beyond histological healingin ulcerative colitis: towards the establishment of a molecular signature for quiescent but progressive disease 10.1136/gutjnl-2012-303765

Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice 10.1136/gutjnl-2011-301785

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer 10.1172/jci62236

The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption 10.1152/ajpgi.00491.2012

Intestinally Secreted C-Type Lectin Reg3b Attenuates Salmonellosis but Not Listeriosis in Mice 10.1128/iai.06165-11

Neutralizing responsiveness to Interleukin-33 abrogat1es experimental colitis through enhanced mucosal wound healing 10.1016/j.cyto.2012.06.183

Defensins couple dysbiosis to primary immunodeficiency in Crohn's disease 10.3748/wjg.v17.i5.567

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury 10.1073/pnas.1100981108

Familial Aggregation and Antimicrobial Response Dose-Dependently Affect the Risk for Crohn's Disease 10.1002/ibd.20985

Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease 10.1016/j.it.2010.01.007

Longest Form of CCTG Microsatellite Repeat in the Promoter of the CD2BP1/PSTPIP1 Gene Is Associated with Aseptic Abscesses and with Crohn Disease in French Patients 10.1007/s10620-009-0929-7

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon 10.1073/pnas.0905745107

Remote Control of Intestinal Tumorigenesis by Innate Immunity 10.1158/0008-5472.can-09-3401

Candida albicans Colonization and ASCA in Familial Crohn's Disease 10.1038/ajg.2009.225

Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease 10.1371/journal.pone.0004496

Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis 10.1136/gut.2008.168443

Detection of antisynthetic mannoside antibodies (A Sigma MA) reveals heterogeneity in the ASCA response of Crohn's disease patients and contributes to differential diagnosis, stratification, and prediction 10.1111/j.1572-0241.2007.01648.x

NOD2: a potential target for regulating liver injury 10.1038/labinvest.3700716

How NOD2 mutations predispose to Crohn's disease? 10.1016/j.micinf.2007.01.016

IBD serological panels: Facts and perspectives 10.1002/ibd.20226

Involvement of NOD2 signalling in hepatocyte and immune cells during hepatitis 10.1016/s0168-8278(07)61628-6

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors 10.1038/nm1521

Mesenteric fat in Crohn's disease: A pathogenetic hallmark or an innocent bystander? 10.1136/gut.2005.082925

mu-Opioid receptor activation prevents acute hepatic inflammation and cell death 10.1136/gut.2006.105122

Nod-like receptors: Cytosolic watchdogs for immunity against pathogens 10.1371/journal.ppat.0030152

NOD2 and defensins: translating innate to adaptive immunity in Crohn's disease 10.1177/0968051907080429

Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein 10.1053/j.gastro.2007.06.018

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Microbial induction of CARD15 expression in-intestinal epithelial cells via toll-like receptor 5 triggers an antibacterial response loop 10.1002/jcp.20739

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NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation 10.1016/j.tim.2006.08.008

PPAR gamma as a new therapeutic in inflammatory bowel diseases 10.1136/gut.2006.093484

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Regulatory role of Nod2 in intestinal immunity 10.1016/s0399-8320(04)95209-8

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid 10.1038/ni945

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CARD4/NOD1 is not involved in inflammatory bowel disease 10.1136/gut.52.1.71

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CARD15 mutations in Blau syndrome 10.1038/ng720

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Globin genes in Guadeloupe: vestige of slavery 10.1016/s0369-8114(01)00198-5

Genetic analyses of chromosome 12 loci in Crohn's disease 10.1136/gut.47.6.787

A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation 10.1038/mi.2017.87

Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence 10.1136/gutjnl-2017-314195

Integrin a6 loss promotes colitis-associated colorectal cancer. Response to: "Integrin a6 variants and colorectal cancer" by Beaulieu JF 10.1136/gutjnl-2017-315727 10.1136/gutjnl-2017-315727.

MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype 10.1073/pnas.1722372115

Understanding the Cellular Origin of the Mononuclear Phagocyte System Sheds Light on the Myeloid Postulate of immune Paralysis in Sepsis 10.3389/fimmu.2018.00823

Effects of enteral polymeric diet on gut microbiota in children with Crohn's disease 10.1136/gutjnl-2015-311058

Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota 10.1080/2162402x.2015.1132137

Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice 10.1053/j.gastro.2017.05.010

Hemidesmosome integrity protects the colon against colitis and colorectal cancer 10.1136/gutjnl-2015-310847

Intestinal microbiota: what to expect physiologically and therapeutically? 10.1016/j.therap.2017.01.001

Keeping the (S)toolbox Alive Outside of the Body for Drugs Discovery 10.1053/j.gastro.2017.10.022 10.1053/j.gastro.2017.10.022.

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619

The battlefield in the war against attaching-and-effacing bacterial pathogens: Monocytes, macrophages and dendritic cells in action 10.1016/j.vetmic.2016.09.007

The human gut microbiome as source of innovation for health: Which physiological and therapeutic outcomes could we expect? 10.1016/j.therap.2016.12.007

Type I interferons drive inflammasome-independent emergency monocytopoiesis during endotoxemia 10.1038/s41598-017-16869-2

A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies 10.1016/j.ajhg.2016.02.025

Defining dysbiosis threatens Koch's postulates and current dogma on the role of Paneth cells in Crohn's disease 10.1136/gutjnl-2015-309333

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects 10.1016/j.immuni.2016.09.009

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation 10.1016/j.celrep.2016.07.054

Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome 10.1158/0008-5472.can-16-0448

NOD2 gene variant is a risk factor for postoperative complications in patients with Crohn's disease: A genetic association study 10.1016/j.surg.2016.01.013

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors 10.1016/j.immuni.2016.06.001

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota 10.1126/science.aad1329

CARD8 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease 10.1016/j.dld.2015.07.013

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation 10.1093/jmcb/mjy012

Gut microbiome and anticancer immune response: really hot Sh(star)t! 10.1038/cdd.2014.56

Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth 10.1038/ncb3206

Photodynamic therapy as a new treatment modality for inflammatory and infectious conditions 10.1586/1744666x.2015.1032256

Photodynamic Therapy Relieves Colitis and Prevents Colitis-associated Carcinogenesis in Mice 10.1097/mib.0000000000000354

Time for epithelial sensing of vitamin D to step into the limelight 10.1136/gutjnl-2014-308119

Role of NLRs in the Regulation of Type I Interferon Signaling, Host Defense and Tolerance to Inflammation 10.3390/ijms22031301

Martin Cohen-Gonsaud

Cohen-Gonsaud Martin

ORCID: 0000-0002-0150-9912

Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the global transcriptional regulator Lsr2 10.1101/571406

Structural basis for chemically-induced homodimerization of a single domain antibody. 10.1038/s41598-019-38752-y

Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis. 10.1016/j.celrep.2018.09.004

Author Correction: Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia. 10.1038/s41467-018-03799-4

Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia. 10.1038/s41467-017-02749-w

A Modular Receptor Platform To Expand the Sensing Repertoire of Bacteria. 10.1021/acssynbio.7b00266

Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization. 10.1016/j.str.2016.07.009

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. 10.1111/cmi.12619

Phosphorylation-mediated regulation of the Staphylococcus aureus secreted tyrosine phosphatase PtpA. 10.1016/j.bbrc.2015.11.123

The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth. 10.1098/rsob.150025

Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system. 10.1371/journal.pone.0119907

Chromatin insulator factors involved in long-range DNA interactions and their role in the folding of the Drosophila genome. 10.1371/journal.pgen.1004544

The RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation-promoting factor catalytic domain. 10.1107/S2053230X1401317X

Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria. 10.1074/jbc.M114.577338

A novel mode of regulation of the Staphylococcus aureus Vancomycin-resistance-associated response regulator VraR mediated by Stk1 protein phosphorylation. 10.1016/j.bbrc.2014.03.128

Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions. 10.1128/AAC.02774-13

Equivalence between Euler angle conventions for the description of tensorial interactions in liquid NMR: application to different software programs. 10.1007/s10858-013-9790-2

Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation. 10.1016/j.bbrc.2012.11.038

A novel mode of regulation of the Staphylococcus aureus catabolite control protein A (CcpA) mediated by Stk1 protein phosphorylation. 10.1074/jbc.M112.418913

The C-terminal domain of the virulence factor MgtC is a divergent ACT domain. 10.1128/JB.01424-12

Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase. 10.1016/j.str.2011.07.011

The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation. 10.1016/j.str.2010.02.013

Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis. 10.1074/jbc.M110.105189

The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation. 10.1074/jbc.M109.019653

Dynamic and structural characterization of a bacterial FHA protein reveals a new autoinhibition mechanism. 10.1016/j.str.2009.02.012

The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c. 10.1002/pmic.200700442

Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies. 10.1107/s0907444907024158

Bacterial resuscitation factors: revival of viable but non-culturable bacteria. 10.1007/s00018-006-6188-2

Wake up! Peptidoglycan lysis and bacterial non-growth states. 10.1016/j.tim.2006.04.003

Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change. 10.1002/prot.20494

The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes. 10.1038/nsmb905

(1)H, (15)N, and (13)C chemical shift assignments of the resuscitation promoting factor domain of Rv1009 from Mycobacterium tuberculosis. 10.1007/s10858-004-3466-x

Resuscitation-promoting factors possess a lysozyme-like domain. 10.1016/j.tibs.2003.10.009

In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid. 10.1128/AAC.48.1.242-249.2004

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors. 10.1073/pnas.0304699101

Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis. 10.1016/s0022-2836(02)00463-1

Romain Veyron-Churlet

Veyron-Churlet Romain

ORCID: 0000-0001-6902-5917

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371

Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization. 10.1016/j.str.2016.07.009

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. 10.1111/cmi.12619

Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins. 10.1021/jm5008819

Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis. 10.1371/journal.ppat.1004115

A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. 10.1038/nchembio.1277

The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes. 10.1371/journal.pone.0029564

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation. 10.1172/jci66576

Expression of OmpATb is dependent on small membrane proteins in Mycobacterium bovis BCG. 10.1016/j.tube.2011.06.008

Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring. 10.1371/journal.pntd.0001237

Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. 10.1111/j.1365-2958.2010.07446.x

Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis. 10.1074/jbc.m110.105189

The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue. 10.1074/jbc.m806537200

The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions. 10.1016/j.jmb.2005.09.016

Protein-protein interactions within the Fatty Acid Synthase-II system of Mycobacterium tuberculosis are essential for mycobacterial viability. 10.1111/j.1365-2958.2004.04334.x

Rv0613c/MSMEG_1285 Interacts with HBHA and Mediates Its Proper Cell-Surface Exposure in Mycobacteria 10.3390/ijms19061673

In Vivo Methods to Study Protein-Protein Interactions as Key Players in Mycobacterium Tuberculosis Virulence. 10.3390/pathogens8040173

Protein scaffold involving MSMEG_1285 maintain cell wall organization and mediates penicillin sensitivity in mycobacteria. 10.1111/febs.15232

In Vivo Methods to Study Protein-Protein Interactions as Key Players in Mycobacterium tuberculosis Virulence 10.20944/preprints201908.0309.v1

Interconnection of the mycobacterial heparin-binding hemagglutinin with cholesterol degradation and heme/iron pathways identified by proximity-dependent biotin identification in Mycobacterium smegmatis. 10.1111/1462-2920.15547