Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ
Jang, J.
Stella, A.
Boudou, F.
Levillain, F.
Darthuy, E.
Vaubourgeix, J.
Wang, C.
Bardou, F.
Puzo, G.
Gilleron, M.
Burlet-Schiltz, O.
Monsarrat, B.
Brodin, P.
Gicquel, B.
Neyrolles, O.
Microbiology (Reading, England), 2010-6
Martine GILLERON
GILLERON Martine
ORCID: 0000-0002-2581-3302
Email: margilleron@gmail.com
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Priscille Brodin
Brodin Priscille
ORCID: 0000-0003-0991-7344
Email: priscille.brodin@inserm.fr
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Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
10.1021/jm300377g
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease.
10.1186/1753-6561-5-s1-p38
Automated HTS/HCS for antivirals using visual HIV full replication assays.
10.1186/1742-4690-6-s2-p82
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system.
10.4049/jimmunol.174.6.3570
Cell microbiology interview
10.1111/cmi.13288
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts
10.1099/mgen.0.000505
Odile Schiltz
Schiltz Odile
/ Burlet-Schiltz
/ Schiltz
ORCID: 0000-0002-3606-2356
The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation
10.1084/jem.20201011
Long non-coding RNA Neat1 is a key translational regulator in hypoxia
10.1101/2021.02.10.430272
Phosphoproteomic analysis of the mouse brain mu-opioid (MOP) receptor
10.1016/j.febslet.2015.07.025
MzDB: A file format using multiple indexing strategies for the efficient analysis of large LC-MS/MS and SWATH-MS data sets
10.1074/mcp.O114.039115
Comparative shotgun proteomic analysis of wild and domesticated Opuntia spp. species shows a metabolic adaptation through domestication
10.1016/j.jprot.2016.04.003
PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ
10.1073/pnas.1722299115
The production of a new MAGE-3 peptide presented to cytolytic T lymphocytes by HLA-B40 requires the immunoproteasome
10.1084/jem.20011974
Mechanistic insights into the impact of Cold Atmospheric Pressure Plasma on human epithelial cell lines
10.1038/srep41163
Detection of IgE-reactive proteins in hydrolysed dog foods
10.1111/vde.12473
CyclinD-CDK4/6 complexes phosphorylate CDC25A and regulate its stability
10.1038/onc.2016.506
Looking for Missing Proteins in the Proteome of Human Spermatozoa: An Update
10.1021/acs.jproteome.6b00400
Chronic ethanol feeding affects proteasome-interacting proteins
10.1002/pmic.200800959
Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism
10.1016/j.celrep.2019.12.089
Tyrosine-dependent capture of CAP-Gly domain-containing proteins in complex mixture by EB1 C-terminal peptidic probes
10.1016/j.jprot.2012.04.006
Mascot file parsing and quantification (MFPaQ), a new software to parse, validate, and quantify proteomics data generated by ICAT and SILAC mass spectrometric analyses: Application to the proteomics study of membrane proteins from primary human endothelial cells
10.1074/mcp.T600069-MCP200
Revisiting the timing of action of the PAG adaptor using quantitative proteomics analysis of primary t cells
10.4049/jimmunol.1501300
NanoLC-MS/MS Analysis Provides New Insights into the Phosphorylation Pattern of Cdc25B in Vivo: Full Overlap with Sites of Phosphorylation by Chk1 and Cdk1/cycB Kinases in Vitro
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DNA damage induce γ-tubulin-RAD51 nuclear complexes in mammalian cells
10.1038/sj.onc.1208723
Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells
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Computational and mass-spectrometry-based workflow for the discovery and validation of missing human proteins: Application to chromosomes 2 and 14
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Toward a full characterization of the human 20S proteasome subunits and their isoforms by a combination of proteomic approaches
10.1007/978-1-59745-398-1_8
Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response
10.1038/s41598-017-08489-7
Label-free quantification and shotgun analysis of complex proteomes by one-dimensional SDS-page/NanoLC-MS: Evaluation for the large scale analysis of inflammatory human endothelial cells
10.1074/mcp.M111.015230
Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development
10.1074/mcp.M112.020727
A quantitative proteomic approach using two-dimensional gel electrophoresis and isotope-coded affinity tag labeling for studying human 20S proteasome heterogeneity
10.1002/pmic.200401281
Proteasome inhibitor-induced apoptosis in acute myeloid leukemia: A correlation with the proteasome status
10.1016/j.leukres.2009.09.020
VisioProt-MS: Interactive 2D maps from intact protein mass spectrometry
10.1093/bioinformatics/bty680
Subcellular distribution and dynamics of active proteasome complexes unraveled by a workflow combining in vivo complex cross-linking and quantitative proteomics
10.1074/mcp.M112.023317
Proteomic analysis of anaplastic lymphoma cell lines: Identification of potential tumour markers
10.1002/pmic.200500647
Identification of proNeuropeptide FFA peptides processed in neuronal and non-neuronal cells and in nervous tissue
10.1046/j.1432-1033.2003.03816.x
The two-step cleavage activity of PI-TfuI intein endonuclease demonstrated by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
10.1074/jbc.M203507200
Determination of differentially regulated proteins upon proteasome inhibition in AML cell lines by the combination of large-scale and targeted quantitative proteomics
10.1002/pmic.201600089
Scaled-down purification protocol to access proteomic analysis of 20S proteasome from human tissue samples: Comparison of normal and tumor colorectal cells
10.1021/pr8000749
Insights into the Allergenic Potential of the Edible Yellow Mealworm (Tenebrio molitor)
10.3390/foods8100515
PKB/Akt phosphorylates the CDC25B phosphatase and regulates its intracellular localisation
10.1016/j.biolcel.2003.08.001
LYR3, a high-affinity LCO-binding protein of Medicago truncatula, interacts with LYK3, a key symbiotic receptor
10.1002/1873-3468.12191
Proteomics to study the diversity and dynamics of proteasome complexes: From fundamentals to the clinic
10.1586/epr.11.41
Analysis of 5000 year-old human teeth using optimized large-scale and targeted proteomics approaches for detection of sex-specific peptides
10.1016/j.jprot.2019.103548
Improved sensitivity of biomolecular interaction analysis mass spectrometry for the identification of interacting molecules
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GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF 2 ) receptors
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Affinity purification strategy to capture human endogenous proteasome complexes diversity and to identify proteasome-interacting proteins
10.1074/mcp.M800193-MCP200
Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis
10.1371/journal.pgen.1006932
The use of mass spectrometry to identify antigens from proteasome processing
10.1016/S0076-6879(05)05011-1
Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
10.1038/ncomms10230
The proteome of the human breast cancer cell line MDA-MB-231: Analysis by LTQ-Orbitrap mass spectrometry
10.1002/prca.200800083
Structural basis of extended spectrum TEM β-lactamases: Crystallographic, kinetic, and mass spectrometric investigations of enzyme mutants
10.1074/jbc.271.18.10482
Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1
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Label-free quantitative proteomic analysis of human plasma-derived microvesicles to find protein signatures of abdominal aortic aneurysms
10.1002/prca.201400010
The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae
10.4161/rna.8.6.17699
Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase
10.1016/j.bbrc.2011.05.110
Alloantibodies against MHC class I: A novel mechanism of neonatal pancytopenia linked to vaccination
10.4049/jimmunol.1102533
SILAC-based proteomic profiling of the human MDA-MB-231 metastatic breast cancer cell line in response to the two antitumoral lactoferrin isoforms: The secreted lactoferrin and the intracellular delta-lactoferrin
10.1371/journal.pone.0104563
Proteomic analysis of regulatory T cells reveals the importance of Themis1 in the control of their suppressive function
10.1074/mcp.M116.062745
HDX-Viewer: interactive 3D visualization of hydrogen-deuterium exchange data
10.1093/bioinformatics/btz550
Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation
10.15252/msb.20166837
Metabolome and proteome changes between biofilm and planktonic phenotypes of the marine bacterium Pseudoalteromonas lipolytica TC8
10.1080/08927014.2017.1413551
Identification of neuropeptide FF-related peptides in rodent spinal cord
10.1016/S0196-9781(01)00425-9
Purification and proteomic analysis of 20S proteasomes from human cells
10.1007/978-1-59745-28-7_21
Extracellular IL-33 cytokine, but not endogenous nuclear IL-33, regulates protein expression in endothelial cells
10.1038/srep34255
DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal
10.1093/nar/gku601
Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer
10.1158/0008-5472.CAN-16-0651
Label-free quantitative urinary proteomics identifies the arginase pathway as a new player in congenital obstructive nephropathy
10.1074/mcp.M114.040121
The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells
10.1126/scisignal.aar3083
Comparing 22 Popular Phosphoproteomics Pipelines for Peptide Identification and Site Localization
10.1021/acs.jproteome.9b00679
Asb2α-filamin a axis is essential for actin cytoskeleton remodeling during heart development
10.1161/CIRCRESAHA.117.312015
Deeper in the human cornea proteome using nanoLC-Orbitrap MS/MS: An improvement for future studies on cornea homeostasis and pathophysiology
10.1016/j.jprot.2011.09.020
Promoter-dependent translation controlled by p54nrb and hnRNPM during myoblast differentiation
10.1371/journal.pone.0136466
Extensive analysis of the cytoplasmic proteome of human erythrocytes using the peptide ligand library technology and advanced mass spectrometry
10.1074/mcp.M800037-MCP200
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease
10.1038/s41598-018-26282-y
TOM1 is a PI5P effector involved in the regulation of endosomal maturation
10.1242/jcs.166314
Mapping and structural dissection of human 20 S proteasome using proteomic approaches.
10.1074/mcp.M200030-MCP200
Analysis of durum wheat proteome changes under marine and fungal biostimulant treatments using large-scale quantitative proteomics: A useful dataset of durum wheat proteins
10.1016/j.jprot.2019.03.003
A screen for deubiquitinating enzymes involved in the G2 /M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability
10.4161/cc.9.18.13133
Deimination of human filaggrin-2 promotes its proteolysis by calpain
10.1074/jbc.M110.197400
The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis
10.1074/jbc.M109.006940
The asparagine to aspartic acid substitution at position 276 of TEM-35 and TEM-36 is involved in the β-lactamase resistance to clavulanic acid
10.1074/jbc.270.31.18240
Erratum: Label-free quantitative proteomics reveals the dynamics of proteasome complexes composition and stoichiometry in a wide range of human cell lines (Journal of Proteome Research (2014) 13:6 (3027-3037) DOI: 10.1021/pr500193k)
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Ser/Thr phosphorylation regulates the fatty Acyl-AMP ligase activity of FadD32, an essential enzyme in mycolic acid biosynthesis
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Quantitative proteomic analysis to decipher the differential apoptotic response of bortezomib-treated APL cells before and after retinoic acid differentiation reveals involvement of protein toxicity mechanisms
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Characterization of protein variants and post-translational modifications: ESI-MSn analyses of intact proteins eluted from polyacrylamide gels.
10.1074/mcp.T300003-MCP200
HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness
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Tipifarnib plus tamoxifen in tamoxifen-resistant metastatic breast cancer: A negative phase II and screening of potential therapeutic markers by proteomic analysis
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Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy
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Structural and functional identification of major histocompatibility complex class I-restricted self-peptides as naturally occurring molecular mimics of viral antigens: Possible role in CD8+ T cell-mediated, virus-induced autoimmune disease
10.1074/jbc.M008864200
Mass spectrometry-based absolute quantification of 20S proteasome status for controlled ex-vivo expansion of human adipose-derived mesenchymal stromal/stem cells
10.1074/mcp.RA118.000958
Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis
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Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells
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Proteomic evidence of specific IGKV1-8 association with cystic lung light chain deposition disease
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Label-free quantitative proteomics reveals the dynamics of proteasome complexes composition and stoichiometry in a wide range of human cell lines
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Identification of neuropeptide FF-related peptides in human cerebrospinal fluid by mass spectrometry
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Spiked proteomic standard dataset for testing label-free quantitative software and statistical methods
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Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
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Deciphering preferential interactions within supramolecular protein complexes: The proteasome case
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First structural insights into α-L-Arabinofuranosidases from the two GH62 glycoside hydrolase subfamilies
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Final antigenic Melan-A peptides produced directly by the proteasomes are preferentially selected for presentation by HLA-A*0201 in melanoma cells
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A transgenic mouse model reproduces human hereditary systemic amyloidosis
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Comparison of label-free quantification methods for the determination of protein complexes subunits stoichiometry
10.1016/j.euprot.2014.06.001
The intestinal glucose-apelin cycle controls carbohydrate absorption in mice
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Structure of the Mesorhizobium huakuii and Rhizobium galegae Nod factors: A cluster of phylogenetically related legumes are nodulated by rhizobia producing Nod factors with α,β-unsaturated N-acyl substitutions
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Scrutiny of Mycobacterium tuberculosis 19 kDa antigen proteoforms provides new insights in the lipoglycoprotein biogenesis paradigm
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Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane
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Clinical implications of recent advances in proteogenomics
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Benchmarking quantitative label-free LC-MS data processing workflows using a complex spiked proteomic standard dataset
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Identification and functional characterization of the phosphorylation sites of the neuropeptide FF2 receptor
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In-depth exploration of cerebrospinal fluid by combining peptide ligand library treatment and label-free protein quantification
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Identification of specific posttranslational O-mycoloylations mediating protein targeting to the mycomembrane
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Phosphorylation of CDC25A on SER283 in late S/G2 by CDK/cyclin complexes accelerates mitotic entry
10.1080/15384101.2016.1220455
Deciphering the ubiquitin proteome: Limits and advantages of high throughput global affinity purification-mass spectrometry approaches
10.1016/j.biocel.2013.05.031
The exerkine apelin reverses age-associated sarcopenia
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Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33
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Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling
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Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics
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Erratum: The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells (Science Signaling)
10.1126/scisignal.aaw0656
Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability
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Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
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Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ
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Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases
10.1016/j.jid.2016.09.030
The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors
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Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines
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Differential Effects of Phosphorylation on DNA Binding Properties of N Oct-3 Are Dictated by Protein/DNA Complex Structures
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Mass Spectral Kinetic Study of Acylation and Deacylation during the Hydrolysis of Penicillins and Cefotaxime by α-Lactamase TEM-1 and the G238S Mutant
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Eph-mediated tyrosine phosphorylation of citron kinase controls abscission
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Muscle wasting in patients with end-stage renal disease or early-stage lung cancer: common mechanisms at work
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Destructive cleavage of antigenic peptides either by the immunoproteasome or by the standard proteasome results in differential antigen presentation
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Dissociation of pharmacological pro- and anti-opioid effects by neuropeptide FF analogs
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Phosphorylation of serine 323 of ASB2α is pivotal for the targeting of filamin A to degradation
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Decompositions of cationized heterodimers of amino acids in relation to charge location in peptide ions
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Charge promotion of low‐energy fragmentations of peptide ions
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Determination of high-energy fragmentation of protonated peptides using a beqq hybrid mass spectrometer
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Influence of cysteine to cysteic acid oxidation on the collision-activated decomposition of protonated peptides: Evidence for intraionic interactions
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Tandem mass spectrometric characterization of a specific cysteic acid residue in oxidized human apoprotein B-100
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Julien Vaubourgeix
Vaubourgeix Julien
ORCID: 0000-0003-4872-0464
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition
10.1126/science.aau8959
Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.
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Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.
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Building Walls: Work That Never Ends.
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Targeting the Proteostasis Network for Mycobacterial Drug Discovery.
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Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.
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Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death.
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Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.
10.15252/embj.201695028
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
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Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.
10.1016/j.chom.2014.12.008
N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.
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A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone.
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Deciphering sulfoglycolipids of Mycobacterium tuberculosis.
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Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ.
10.1099/mic.0.038133-0
S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases.
10.1074/jbc.M809599200
Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence.
10.1371/journal.ppat.1000204
Biology of antimicrobial resistance and approaches to combat it
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Multiform antimicrobial resistance from a metabolic mutation
10.1126/sciadv.abh2037
Nathalie deboosere
deboosere Nathalie
ORCID: 0000-0002-2873-5485
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton.
10.15252/embr.201744371
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
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A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone.
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Phenotypic assays for Mycobacterium tuberculosis infection.
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Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.
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STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection.
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LppM impact on the colonization of macrophages by Mycobacterium tuberculosis.
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A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening.
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Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces.
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Viral elution and concentration method for detection of influenza A viruses in mud by real-time RT-PCR.
10.1016/j.jviromet.2011.10.013
Comparison of chlorine and peroxyacetic-based disinfectant to inactivate Feline calicivirus, Murine norovirus and Hepatitis A virus on lettuce.
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Direct detection of highly pathogenic avian influenza A/H5N1 virus from mud specimens.
10.1016/j.jviromet.2011.06.002
Development and validation of a concentration method for the detection of influenza a viruses from large volumes of surface water.
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A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries.
10.1016/j.fm.2010.05.018
Assessment of the removal and inactivation of influenza viruses H5N1 and H1N1 by drinking water treatment.
10.1016/j.watres.2010.01.013
Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables.
10.1016/j.ijfoodmicro.2005.11.007
Modelling effect of physical and chemical parameters on heat inactivation kinetics of hepatitis A virus in a fruit model system.
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Host-pathogen systems for early drug discovery against tuberculosis.
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Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids.
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Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis.
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Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages.
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Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.
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Host-directed therapies offer novel opportunities for the fight against tuberculosis.
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Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs.
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Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis.
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Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections.
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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
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How can nanoparticles contribute to antituberculosis therapy?
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Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
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Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.
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Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization.
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Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro.
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[Mycolactone: the amazing analgesic mycobacterial toxin].
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A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.
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Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action.
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Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro.
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Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system.
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Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo.
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Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays.
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2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.
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High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.
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Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.
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Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches.
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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.
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The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence.
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Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
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