Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research
Philip A. Verhoef Sujatha Kannan Jamie L. Sturgill Elizabeth W. Tucker Peter E. Morris Andrew C. Miller Travis R. Sexton Jay L. Koyner Rana Hejal Scott C. Brakenridge Lyle L. Moldawer Richard S. Hotchkiss Teresa M. Blood Monty B. Mazer Scott Bolesta Sheila A. Alexander Donna Lee Armaignac Steven L. Shein Christopher Jones Caroline D. Hoemann Allan Doctor Stuart H. Friess Robert I. Parker Alexandre T. Rotta Kenneth E. Remy
Andrew Miller
Miller Andrew
ORCID: 0000-0001-8474-5090
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Scott Brakenridge
Brakenridge Scott
ORCID: 0000-0002-7327-3718
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The authors reply 10.1097/CCM.0000000000002469
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LETTERS TO the EDITOR 10.1097/00005373-200306000-00047
Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol 10.1097/TA.0000000000001295
Editorial critique 10.1097/TA.0000000000000996
Pathophysiology and Treatment Strategies of Acute Myopathy and Muscle Wasting after Sepsis 10.3390/jcm10091874
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Biomarker Evidence of the Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness (CCI) after Surgical Sepsis 10.1097/sla.0000000000005067
Identification of Unique microRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells after Hemorrhagic Shock and Polytrauma in Young and Old Adult Mice 10.1097/ta.0000000000003350
Chronic critical illness after hypothermia in trauma patients 10.1136/tsaco-2021-000747
Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report 10.1097/cce.0000000000000500
The impact of sarcopenia and acute muscle mass loss on long‐term outcomes in critically ill patients with intra‐abdominal sepsis 10.1002/jcsm.12752
Transcriptomic Changes Within Human Bone Marrow After Severe Trauma 10.1097/shk.0000000000001826
In Vitro–Administered Dexamethasone Suppresses T Cell Function With Reversal by Interleukin-7 in Coronavirus Disease 2019 10.1097/cce.0000000000000378
Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis 10.1093/gerona/glab080
Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research 10.1097/cce.0000000000000374
Immunological Endotyping of Chronic Critical Illness After Severe Sepsis 10.3389/fmed.2020.616694
The Effect of Aging Physiology on Critical Care 10.1016/j.ccc.2020.08.006
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival 10.1093/geroni/igaa057.454
Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes 10.1016/j.amjsurg.2020.07.016
A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients 10.4049/jimmunol.2001088
Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study 10.1097/cce.0000000000000278
Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock 10.1097/ta.0000000000003029
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis 10.1097/sla.0000000000004360
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis 10.1096/fj.202002150r
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study 10.1097/shk.0000000000001671
Immunotherapies for COVID-19: lessons learned from sepsis 10.1016/s2213-2600(20)30217-4
Discovery and Validation of Urinary Molecular Signature of Early Sepsis 10.1097/cce.0000000000000195
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections 10.1172/jci.insight.140329
What's New in Shock, September 2020? 10.1097/shk.0000000000001588
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice 10.1097/shk.0000000000001648
Vitamin D status is associated with hepcidin and hemoglobin concentrations in patients with severe traumatic injury 10.1097/ta.0000000000002895
Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults 10.3389/fimmu.2020.01289
Enteral Nutrition Administration Record Prescribing Process Using Computerized Order Entry: A New Paradigm and Opportunities to Improve Outcomes in Critically Ill Patients 10.1002/jpen.1870
Evaluation and management of blunt cerebrovascular injury: A practice management guideline from the Eastern Association for the Surgery of Trauma 10.1097/ta.0000000000002668
Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study 10.1186/s13054-020-02917-3
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long‐Term Survival 10.1111/jgs.16435
Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness 10.1016/j.surg.2019.11.018
Artificial Intelligence and Surgical Decision-making 10.1001/jamasurg.2019.4917
Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress 10.1097/shk.0000000000001506
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis 10.1186/s13054-019-2628-x
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model* 10.1097/ccm.0000000000003926
Effect of β-Blockade on the Expression of Regulatory MicroRNAs after Severe Trauma and Chronic Stress 10.1016/j.jamcollsurg.2019.08.643
Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab 10.1007/s00134-019-05704-z
Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma 10.1038/s41598-019-50044-z
Current Epidemiology of Surgical Sepsis 10.1097/sla.0000000000003458
Delayed interhospital transfer of critically ill patients with surgical sepsis 10.1097/ta.0000000000002476
Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors 10.1186/s13054-019-2505-7
The authors reply 10.1097/ccm.0000000000003887
Kenneth Remy
Remy Kenneth
ORCID: 0000-0001-5222-9884
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To the editor 10.1056/NEJMc1508390
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Association of Interleukin 7 Immunotherapy with Lymphocyte Counts among Patients with Severe Coronavirus Disease 2019 (COVID-19) 10.1001/jamanetworkopen.2020.16485
Targeted immunosuppression distinguishes COVID-19 from influenza in moderate and severe disease 10.1101/2020.05.28.20115667
High-flow nasal cannula utilization in pediatric critical care 10.4187/respcare.05153
Mechanisms of red blood cell transfusion-related immunomodulation 10.1111/trf.14488
Role of granulocyte transfusions in invasive fusariosis: Systematic review and single-center experience 10.1111/trf.13099
An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis 10.1517/13543784.2015.1041587
In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome 10.1111/trf.13275
Haptoglobin improves shock, lung injury, and survival in canine pneumonia 10.1172/jci.insight.123013
Effects of platelet-sparing leukocyte reduction and agitation methods on in vitro measures of hemostatic function in cold-stored whole blood 10.1097/TA.0000000000001870
Transfused older stored red blood cells improve the clinical course and outcome in a canine lethal hemorrhage and reperfusion model 10.1111/trf.13213
Changes in Pediatric ICU Utilization and Clinical Trends During the Coronavirus Pandemic 10.1016/j.chest.2021.03.004
Red blood cell storage age – what we know from clinical trials 10.1080/17474086.2016.1243051
Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness 10.1111/trf.13855
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High-flow oxygen as noninvasive ventilation may complicate timely intubation in patients with acute respiratory distress syndrome 10.1097/CCM.0000000000001782
Consensus recommendations for rbc transfusion practice in critically Ill children from the pediatric critical care transfusion and Anemia expertise initiative 10.1097/PCC.0000000000001613
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections 10.1172/jci.insight.140329
Caring for Critically Ill Adults with Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists∗ 10.1097/PCC.0000000000002429
IL-10 has differential effects on the innate and adaptive immune systems of septic patients 10.4049/jimmunol.1900637
The influence of the storage lesion(s) on pediatric red cell transfusion 10.1097/MOP.0000000000000224
Coronavirus Disease 2019: A Pandemic Spawning an Infodemic∗ 10.1097/PCC.0000000000002782
Sedation protocol for critically ill pediatric patients 10.1001/jama.2015.3459
A Peptide-Based Checkpoint Immunomodulator Alleviates Immune Dysfunction in Murine Polymicrobial Sepsis 10.1097/SHK.0000000000001682
Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report. 10.1097/cce.0000000000000500
IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis. 10.1093/ofid/ofab256
In Vitro-Administered Dexamethasone Suppresses T Cell Function With Reversal by Interleukin-7 in Coronavirus Disease 2019. 10.1097/cce.0000000000000378
Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research. 10.1097/cce.0000000000000374
Dysregulation of the Leukocyte Signaling Landscape during Acute COVID-19 10.21203/
Delayed Development of Coronary Artery Dilitation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed. 10.1097/cce.0000000000000236
Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. 10.1097/pcc.0000000000002160
Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. 10.1001/jama.2019.17478
Implementation of the Recommendations for RBC Transfusions for Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 10.1097/pcc.0000000000001592
Recommendations on Selection and Processing of RBC Components for Pediatric Patients From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 10.1097/pcc.0000000000001625
Recommendations on the Indications for RBC Transfusion for the Critically Ill Child Receiving Support From Extracorporeal Membrane Oxygenation, Ventricular Assist, and Renal Replacement Therapy Devices From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 10.1097/pcc.0000000000001600
Recommendations on RBC Transfusion Support in Children With Hematologic and Oncologic Diagnoses From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 10.1097/pcc.0000000000001610
Recommendations on RBC Transfusion in Infants and Children With Acquired and Congenital Heart Disease From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 10.1097/pcc.0000000000001603
Recommendations on RBC Transfusion in Critically Ill Children With Acute Brain Injury From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 10.1097/pcc.0000000000001589
Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 10.1097/pcc.0000000000001605
Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 10.1097/pcc.0000000000001620
Recommendations on RBC Transfusions in Critically Ill Children With Acute Respiratory Failure From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. 10.1097/pcc.0000000000001619
The Pediatric Critical Care Transfusion and Anemia Expertise Initiative Consensus Conference Methodology. 10.1097/pcc.0000000000001593
Successful Surgical Repair and Perioperative Management of 6-Month-Old With Total Anomalous Pulmonary Venous Return in a Developing Country: Considerations for the Treatment of Pulmonary Hypertension. 10.14740/cr651w
Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support. 10.1186/s40635-017-0159-9
Outcomes of vagal nerve stimulation in a pediatric population: a single center experience. 10.1016/j.seizure.2013.10.002
Age-related differences in emotional reactivity, regulation, and rejection sensitivity in adolescence. 10.1037/a0028297
A place at the table for children in the ebola virus disease discussion 10.1097/PCC.0000000000000368
Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia 10.1182/blood-2013-11-539353
Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia 10.1111/trf.12607
Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle 10.1152/ajplung.00068.2013
B. anthracis associated cardiovascular dysfunction and shock: The potential contribution of both non-toxin and toxin components 10.1186/1741-7015-11-217
B. anthracis edema toxin increases cAMP levels and inhibits phenylephrinestimulated contraction in a rat aortic ring model 10.1152/ajpheart.00185.2013
Cerebellar metastatic papillary thyroid carcinoma in a pediatric patient with complex congenital heart disease 10.1515/jpem-2012-0162
Physiologic Foundations of Cardiopulmonary Resuscitation 10.1016/B978-0-323-07307-3.10033-3
Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines. 10.1186/s40635-015-0043-4
Immunizations (Adult) 10.1007/978-0-387-33754-8_240
Faculty of 1000 evaluation for Ventilator-associated pneumonia in pediatric trauma patients. 10.3410/f.1162712.624295
Faculty of 1000 evaluation for Association between ICU admission during morning rounds and mortality. 10.3410/f.1704956.2142056
Enterococcus Pseudoavium Sepsis In A 50 Year Old Male With B Cell Lymphoma 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4597
Granuloycte Therapy As Treatment For Candida Parapsilosis Sepsis In An Aplastic Anemia Patient 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4600
Faculty of 1000 evaluation for The role of intestinal colonization with gram-negative bacteria as a source for intensive care unit-acquired bacteremia. 10.3410/f.10436956.11268054
Faculty of 1000 evaluation for Cold aortic flush and chest compressions enable good neurologic outcome after 15 mins of ventricular fibrillation in cardiac arrest in pigs. 10.3410/f.5278957.5220056
Faculty of 1000 evaluation for Early exercise in critically ill patients enhances short-term functional recovery. 10.3410/f.1354956.1186054
Faculty of 1000 evaluation for Infectious risk associated with arterial catheters compared with central venous catheters. 10.3410/f.3285957.2971055
Faculty of 1000 evaluation for Influence of vasopressor agent in septic shock mortality. Results from the Portuguese Community-Acquired Sepsis Study (SACiUCI study). 10.3410/f.1148122.618516
Novel Expression Of The TMEM16 Family Of Calcium Activated Chloride Channels In Human Airway Epithelium And Smooth Muscle Cells 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6035