The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters
Kai Blin Victòria Pascal Andreu Emmanuel L C de Los Santos Francesco Del Carratore Sang Yup Lee Marnix H. Medema Tilmann Weber
Nucleic Acids Research, 2019-1-8
https://doi.org/10.1093/nar/gky1060
Kai Blin
Blin Kai
ORCID: 0000-0003-3764-6051
antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers. 10.1093/nar/gkt449
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antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. 10.1093/nar/gkr466
NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity. 10.1093/nar/gkr323
DoRiNA 2.0-upgrading the doRiNA database of RNA interactions in post-transcriptional regulation. 10.1093/nar/gku1180
Improved lanthipeptide detection and prediction for antiSMASH. 10.1371/journal.pone.0089420
Proteomic approach to reveal the regulatory function of aconitase AcnA in oxidative stress response in the antibiotic producer Streptomyces viridochromogenes Tu494. 10.1371/journal.pone.0087905
Complete genome sequence of the kirromycin producer Streptomyces collinus Tu 365 consisting of a linear chromosome and two linear plasmids. 10.1016/j.jbiotec.2013.10.004
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters 10.1093/nar/gkv437
Minimum Information about a Biosynthetic Gene cluster 10.1038/nchembio.1890
The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters 10.1093/nar/gkw960
Ten Simple Rules for Taking Advantage of Git and GitHub 10.1371/journal.pcbi.1004947
Dissemination of antibiotic resistance genes from antibiotic producers to pathogens 10.1038/ncomms15784
plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters 10.1093/nar/gkx305
antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification 10.1093/nar/gkx319
The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery 10.1093/nar/gkx360
Engineering of actinomycetes using CRISPR/Cas9 technologies 10.1055/s-0036-1596147
Recent development of computational resources for new antibiotics discovery 10.1016/j.mib.2017.10.027
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Bioconda: sustainable and comprehensive software distribution for the life sciences 10.1038/s41592-018-0046-7
The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters 10.1093/nar/gky1060
CRISPR-BEST: a highly efficient DSB-free base editor for filamentous actinomycetes 10.1101/582403
Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH 10.1007/s10295-018-02131-9
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline 10.1093/nar/gkz310
MIBiG 2.0: a repository for biosynthetic gene clusters of known function 10.1093/nar/gkz882
Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters 10.1093/bib/bbx146
Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST 10.1073/pnas.1913493116
Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast 10.1016/j.synbio.2020.01.004
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ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining 10.1093/nar/gkaa374
BiG-FAM: the biosynthetic gene cluster families database 10.1093/nar/gkaa812
The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes 10.1093/nar/gkaa978
antiSMASH 6.0: improving cluster detection and comparison capabilities 10.1093/nar/gkab335
A Regulator Based “Semi-Targeted” Approach to Activate Silent Biosynthetic Gene Clusters 10.3390/ijms22147567
Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260 10.1021/acschembio.1c00318
Sang Yup Lee
Lee Sang Yup
ORCID: 0000-0003-0599-3091
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AntiSMASH 3.0-A comprehensive resource for the genome mining of biosynthetic gene clusters 10.1093/nar/gkv437
Recent advances in systems metabolic engineering tools and strategies 10.1016/j.copbio.2017.06.007
Highly selective production of succinic acid by metabolically engineered Mannheimia succiniciproducens and its efficient purification 10.1002/bit.25988
Efficient gene knockdown in Clostridium acetobutylicum by synthetic small regulatory RNAs 10.1002/bit.26077
Biosynthesis of poly(2-hydroxybutyrate-co-lactate) in metabolically engineered Escherichia coli 10.1007/s12257-015-0749-x
Production of Bacillus thuringiensis spores in total cell retention culture and two‐stage continuous culture using an internal ceramic filter system 10.1002/bit.260420913
Label-free and real-time detection of avian influenza using nanowire field effect transistors 10.1166/jbn.2015.1501
Metabolic engineering of Escherichia coli for the production of four-, five- and six-carbon lactams 10.1016/j.ymben.2017.04.001
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Production of poly(3‐hydroxybutyric acid) by fed‐batch culture of Alcaligenes eutrophus with glucose concentration control 10.1002/bit.260430908
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Comparison of recombinant Escherichia coli strains for synthesis and accumulation of poly‐(3‐hydroxybutyric acid) and morphological changes 10.1002/bit.260441110
Biosynthesis of poly(2-hydroxyisovalerate-co-lactate) by metabolically engineered Escherichia coli 10.1002/biot.201600420
Engineering the xylose-catabolizing Dahms pathway for production of poly(d-lactate-co-glycolate) and poly(d-lactate-co-glycolate-co-d-2-hydroxybutyrate) in Escherichia coli 10.1111/1751-7915.12721
Systems metabolic engineering as an enabling technology in accomplishing sustainable development goals 10.1111/1751-7915.12766
Biosynthesis of 2-hydroxyacid-containing polyhydroxyalkanoates by employing butyryl-CoA transferases in metabolically engineered Escherichia coli 10.1002/biot.201700116
Charge and dielectric effects of biomolecules on electrical characteristics of nanowire FET biosensors 10.1063/1.5003106
Formic acid as a secondary substrate for succinic acid production by metabolically engineered Mannheimia succiniciproducens 10.1002/bit.26435
Framework and resource for more than 11,000 gene-transcript-protein-reaction associations in human metabolism 10.1073/pnas.1713050114
Toward Systems Metabolic Engineering of Streptomycetes for Secondary Metabolites Production 10.1002/biot.201700465
Metabolic Engineering of Microorganisms for the Production of Natural Compounds 10.1002/adbi.201700190
Characterisation of the antibacterial properties of the recombinant phage endolysins AP50-31 and LysB4 as potent bactericidal agents against Bacillus anthracis 10.1038/s41598-017-18535-z
One-step fermentative production of aromatic polyesters from glucose by metabolically engineered Escherichia coli strains 10.1038/s41467-017-02498-w
Engineering tunable biosensors for monitoring putrescine in Escherichia coli 10.1002/bit.26521
Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation 10.1038/s41467-018-02881-1
Membrane engineering via trans-unsaturated fatty acids production improves succinic acid production in Mannheimia succiniciproducens 10.1007/s10295-018-2016-6
Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions 10.1038/s41598-018-21507-6
Recent Trends in Nanomaterials-Based Colorimetric Detection of Pathogenic Bacteria and Viruses 10.1002/smtd.201700351
Developing a piggyBac Transposon System and Compatible Selection Markers for Insertional Mutagenesis and Genome Engineering in Yarrowia lipolytica 10.1002/biot.201800022
Genome Variations of Evolved Escherichia coli ET8 With a Rhodopsin-Based Phototrophic Metabolism 10.1002/biot.201700497
Deep learning improves prediction of drug–drug and drug–food interactions 10.1073/pnas.1803294115
Recombinant Escherichia coli as a biofactory for various single- and multi-element nanomaterials 10.1073/pnas.1804543115
Metabolomics for industrial fermentation 10.1007/s00449-018-1967-3
Synthetic Biology for Natural Compounds 10.1021/acs.biochem.8b00569
Production of ethylene glycol from xylose by metabolically engineered Escherichia coli 10.1002/aic.16339
Metabolic engineering of Escherichia coli for the enhanced production of l ‐tyrosine 10.1002/bit.26797
Metabolic Engineering of Escherichia coli for Efficient Production of 2-Pyrone-4,6-dicarboxylic Acid from Glucose 10.1021/acssynbio.8b00281
Metabolic engineering of Escherichia coli for secretory production of free haem 10.1038/s41929-018-0126-1
Revisiting Statistical Design and Analysis in Scientific Research 10.1002/smll.201802604
Genome-Scale Metabolic Reconstruction of Actinomycetes for Antibiotics Production 10.1002/biot.201800377
Assimilation of formic acid and CO2by engineeredEscherichia coliequipped with reconstructed one-carbon assimilation pathways 10.1073/pnas.1810386115
Repurposing type III polyketide synthase as a malonyl-CoA biosensor for metabolic engineering in bacteria 10.1073/pnas.1808567115
CRISPR/Cas-based genome engineering in natural product discovery 10.1039/C8NP00089A
A comprehensive metabolic map for production of bio-based chemicals 10.1038/s41929-018-0212-4
Engineering Clostridial Aldehyde/Alcohol Dehydrogenase for Selective Butanol Production 10.1128/mBio.02683-18
Protocols for Rec ET ‐based markerless gene knockout and integration to express heterologous biosynthetic gene clusters in Pseudomonas putida 10.1111/1751-7915.13374
Metabolic engineering of microorganisms for production of aromatic compounds 10.1186/s12934-019-1090-4
Reconstruction of context-specific genome-scale metabolic models using multiomics data to study metabolic rewiring 10.1016/j.coisb.2019.02.009
Synthetic biology and metabolic engineering of actinomycetes for natural product discovery 10.1016/j.biotechadv.2019.03.005
Systems Metabolic Engineering Strategies for Non‐Natural Microbial Polyester Production 10.1002/biot.201800426
CRISPR-BEST: a highly efficient DSB-free base editor for filamentous actinomycetes 10.1101/582403
Rational Protein Engineering of Thermo-Stable PETase from Ideonella sakaiensis for Highly Efficient PET Degradation 10.1021/acscatal.9b00568
Advances in CRISPR-Cas systems for RNA targeting, tracking and editing 10.1016/j.biotechadv.2019.03.016
Microbial production of methyl anthranilate, a grape flavor compound 10.1073/pnas.1903875116
Shape-controlled assemblies of graphitic carbon nitride polymer for efficient sterilization therapies of water microbial contamination via 2D g-C3N4 under visible light illumination 10.1016/j.msec.2019.109846
Broad-Spectrum Gene Repression Using Scaffold Engineering of Synthetic sRNAs 10.1021/acssynbio.9b00165
Current status and applications of genome-scale metabolic models 10.1186/s13059-019-1730-3
Engineering of an oleaginous bacterium for the production of fatty acids and fuels 10.1038/s41589-019-0295-5
Deep learning enables high-quality and high-throughput prediction of enzyme commission numbers 10.1073/pnas.1821905116
Genomic and metabolic analysis of Komagataeibacter xylinus DSM 2325 producing bacterial cellulose nanofiber 10.1002/bit.27150
Inside Front Cover: Biotechnology Journal 9/2019 10.1002/biot.201970092
Author Correction: A comprehensive metabolic map for production of bio-based chemicals 10.1038/s41929-019-0358-8
Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST 10.1073/pnas.1913493116
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Enhanced production of cellulose in Komagataeibacter xylinus by preventing insertion of IS element into cellulose synthesis gene 10.1016/j.bej.2020.107527
Systematic and Comparative Evaluation of Software Programs for Template‐Based Modeling of Protein Structures 10.1002/biot.201900343
MEMOTE for standardized genome-scale metabolic model testing 10.1038/s41587-020-0446-y
Metabolic engineering for the synthesis of polyesters: A 100-year journey from polyhydroxyalkanoates to non-natural microbial polyesters 10.1016/j.ymben.2019.05.009
Metabolic engineering for the production of dicarboxylic acids and diamines 10.1016/j.ymben.2019.03.005
Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast 10.1016/j.synbio.2020.01.004
Development of Metabolically Engineered Corynebacterium glutamicum for Enhanced Production of Cadaverine and Its Use for the Synthesis of Bio-Polyamide 510 10.1021/acssuschemeng.9b04693
Current status of pan-genome analysis for pathogenic bacteria 10.1016/j.copbio.2019.12.001
Machine learning applications in systems metabolic engineering 10.1016/j.copbio.2019.08.010
The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters 10.1093/nar/gky1060
Separation and purification of three, four, and five carbon diamines from fermentation broth 10.1016/j.ces.2018.11.018
Microbial production of butyl butyrate, a flavor and fragrance compound 10.1007/s00253-018-09603-z
Expanded synthetic small regulatory RNA expression platforms for rapid and multiplex gene expression knockdown 10.1016/j.ymben.2019.04.003
The urgent need for microbiology literacy in society 10.1111/1462-2920.14611
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline 10.1093/nar/gkz310
Systems Metabolic Engineering Strategies: Integrating Systems and Synthetic Biology with Metabolic Engineering 10.1016/j.tibtech.2019.01.003
Microbial production of 2,3-butanediol for industrial applications 10.1007/s10295-019-02231-0
A safe and sustainable bacterial cellulose nanofiber separator for lithium rechargeable batteries 10.1073/pnas.1905527116
Biocatalytic synthesis of polylactate and its copolymers by engineered microorganisms 10.1016/bs.mie.2019.04.032
Metabolic Engineering of Escherichia coli for the Production of Hyaluronic Acid From Glucose and Galactose 10.3389/fbioe.2019.00351
High‐level production of 3‐hydroxypropionic acid from glycerol as a sole carbon source using metabolically engineered Escherichia coli 10.1002/bit.27344
Synthesis, Characterization, and Application of Fully Biobased and Biodegradable Nylon-4,4 and -5,4 10.1021/acssuschemeng.0c00007
Microbial Polyhydroxyalkanoates and Nonnatural Polyesters 10.1002/adma.201907138
Biosynthesis and characterization of poly( d ‐lactate‐ co ‐glycolate‐ co ‐4‐hydroxybutyrate) 10.1002/bit.27354
A Novel Biosynthetic Pathway for the Production of Acrylic Acid through β-Alanine Route in Escherichia coli 10.1021/acssynbio.0c00019
Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase 10.1038/s41467-020-15839-z
Modeling regulatory networks using machine learning for systems metabolic engineering 10.1016/j.copbio.2020.02.014
Metabolic engineering strategies toward production of biofuels 10.1016/j.cbpa.2020.02.009
Cell Surface Display of Poly(3-hydroxybutyrate) Depolymerase and its Application 10.4014/jmb.2001.01042
Microbial production of 4‐amino‐1‐butanol, a four‐carbon amino alcohol 10.1002/bit.27438
Metabolic Engineering of Escherichia coli for Natural Product Biosynthesis 10.1016/j.tibtech.2019.11.007
Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production 10.1039/D0CS00155D
Formation and functionalization of membraneless compartments in Escherichia coli 10.1038/s41589-020-0579-9
CRISPR–Cas9, CRISPRi and CRISPR-BEST-mediated genetic manipulation in streptomycetes 10.1038/s41596-020-0339-z
Distribution of Epsilon-Polylysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin 10.1101/2020.07.24.220772
CRISPR-nRAGE, a Cas9 nickase-reverse transcriptase assisted versatile genetic engineering toolkit for E. coli 10.1101/2020.09.02.279141
Escherichia coli is engineered to grow on CO2 and formic acid 10.1038/s41564-020-00793-9
Biosynthesis of inorganic nanomaterials using microbial cells and bacteriophages 10.1038/s41570-020-00221-w
Metabolic engineering of Escherichia coli for the production of benzoic acid from glucose 10.1016/j.ymben.2020.10.002
Tunable Gene Expression System Independent of Downstream Coding Sequence 10.1021/acssynbio.0c00029
Characterization and Engineering of Streptomyces griseofuscus DSM 40191 as a Potential Host for Heterologous Expression of Biosynthetic Gene Clusters 10.1101/2020.11.06.372458
Glutaric acid production by systems metabolic engineering of an l-lysine–overproducingCorynebacterium glutamicum 10.1073/pnas.2017483117
Automating Cloning by Natural Transformation 10.1021/acssynbio.0c00240
Transcriptional analysis of immune modulatory genes in melanoma treated with PD-1 blockade 10.1101/2020.12.20.397000
DeepTFactor: A deep learning-based tool for the prediction of transcription factors 10.1073/pnas.2021171118
A deep learning approach to evaluate the feasibility of enzymatic reactions generated by retrobiosynthesis 10.1002/biot.202000605
Microbial production of multiple short-chain primary amines via retrobiosynthesis 10.1038/s41467-020-20423-6
Adapting educational experiences for the chemists of tomorrow 10.1038/s41570-021-00258-5
Machine learning applications in genome-scale metabolic modeling 10.1016/j.coisb.2021.03.001
Distribution of ε-Poly- l -Lysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin 10.1128/AEM.01841-20
Production of Carminic Acid by Metabolically Engineered Escherichia coli 10.1021/jacs.0c12406
High-Level Production of the Natural Blue Pigment Indigoidine from Metabolically Engineered Corynebacterium glutamicum for Sustainable Fabric Dyes 10.1021/acssuschemeng.0c09341
Comparative multi-omics systems analysis of Escherichia coli strains B and K-12 10.1186/gb-2012-13-5-r37
Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches 10.1016/j.biotechadv.2011.08.015
Flux variability scanning based on enforced objective flux for identifying gene amplification targets 10.1186/1752-0509-6-106
Genome-scale metabolic model of the fission yeast Schizosaccharomyces pombe and the reconciliation of in silico/in vivo mutant growth 10.1186/1752-0509-6-49
Label-Free Electrochemical Diagnosis of Viral Antigens with Genetically Engineered Fusion Protein 10.3390/s120810097
Metabolic engineering of Escherichia coli for the production of 1-propanol 10.1016/j.ymben.2012.07.006
Recent advances in reconstruction and applications of genome-scale metabolic models 10.1016/j.copbio.2011.10.007
Characterization of a Bacterial Self-Assembly Surface Layer Protein and Its Application as an Electrical Nanobiosensor 10.1166/jnn.2011.3264
Combining a Nanowire SERRS Sensor and a Target Recycling Reaction for Ultrasensitive and Multiplex Identification of Pathogenic Fungi smll.201100633
Complete Genome Sequence of the Metabolically Versatile Plant Growth-Promoting Endophyte Variovorax paradoxus S110 10.1128/JB.00925-10
Development of Reflective Biosensor Using Fabrication of Functionalized Photonic Nanocrystals 10.1166/jnn.2011.3269
Graph-theoretic approach for identifying catalytic or metabolic pathways 10.1080/02533839.2005.9671080
Combined deterministic-stochastic approach for pharmacokinetic modeling 10.1021/ie0305364
Enhanced production of succinic acid by metabolically engineered Escherichia coli with amplified activities of malic enzyme and fumarase 10.1007/BF02942339
High level production of supra molecular weight poly(3-hydroxybutyrate) by metabolically engineered Escherichia coli 10.1007/BF02942292
Comparative proteomic analysis of four biotechnologically important Escherichia coli strains for rational host selection 10.1016/j.jbiosc.2009.08.473
Identification of sucrose uptake system in Mannheimia succiniciproducens 10.1016/j.nbt.2009.06.617
Improved prediction of metabolic fluxes through genomic context analysis across organisms and stoichiometric analysis of carbon fluxes 10.1016/j.jbiosc.2009.08.471
In silico perturbation of the effects of H(2) and CO(2) on the metabolism of a capnophilic bacterium, Mannheimia succiniciproducens 10.1016/j.jbiosc.2009.08.477
Label-free electrochemical biosensor in highly conductive carbon nanotube and gold nanocomplexes 10.1016/j.jbiosc.2009.08.428
Label-free optical biosensors for the detection of food toxin and pathogen using multi-spot nanoparticle array chip and fusion proteins 10.1016/j.jbiosc.2009.08.429
Metabolic engineering of Escherichia coli for the production of L-isoleucine 10.1016/j.jbiosc.2009.08.472
Metabolic engineering of Escherichia coli for the production of large spider dragline silk proteins 10.1016/j.jbiosc.2009.08.451
Metabolite-centric approach using genome-scale metabolic network for drug targeting of pathogens 10.1016/j.nbt.2009.06.827
Polyhydroxybutyrate microarray for immunodiagnostics and pathogen detections by immobilizing fusion proteins 10.1016/j.nbt.2009.06.078
Synthetic Formatotrophs for One‐Carbon Biorefinery 10.1002/advs.202100199
Escherichia coli as a platform microbial host for systems metabolic engineering 10.1042/EBC20200172
Production of Diversified Polyketides by Metabolic Engineering 10.1021/acs.biochem.1c00290
Production of Rainbow Colorants by Metabolically Engineered Escherichia coli 10.1002/advs.202100743
Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay 10.1073/pnas.2024302118
Three-dimensional label-free visualization and quantification of polyhydroxyalkanoates in individual bacterial cell in its native state 10.1073/pnas.2103956118
In Situ Biosynthesis of a Metal Nanoparticle Encapsulated in Alginate Gel for Imageable Drug-Delivery System 10.1021/acsami.1c02286
Applications of artificial intelligence to enzyme and pathway design for metabolic engineering 10.1016/j.copbio.2021.07.024
Microbial food: microorganisms repurposed for our food 10.1111/1751-7915.13911
A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing 10.1038/s41467-021-25541-3
Tilmann Weber
Weber Tilmann
ORCID: 0000-0002-8260-5120
Die Struktur des Cyclodecatriens Collinolacton, seine Biosynthese und semisynthetische Derivate: monopolare Spindeln und Schutz vor intrazellulärem oxidativem Stress 10.1002/ange.202106802
The Structure of Cyclodecatriene Collinolactone, its Biosynthesis, and Semisynthetic Analogues: Effects of Monoastral Phenotype and Protection from Intracellular Oxidative Stress 10.1002/anie.202106802
Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a 35-Module Type I Polyketide Synthase 10.1128/MRA.00805-21
antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters. 10.1093/nar/gkv437
CRISPR-Cas9 Based Engineering of Actinomycetal Genomes. 10.1021/acssynbio.5b00038
Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes. 10.1016/j.tibtech.2014.10.009
Elucidating the molecular physiology of lantibiotic NAI-107 production in Microbispora ATCC-PTA-5024. 10.1186/s12864-016-2369-z
Bioinformatics Tools for the Discovery of New Nonribosomal Peptides. 10.1007/978-1-4939-3375-4_14
The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ("Penicillium islandicum"). 10.1111/1462-2920.13294
CLUSEAN, Overview 10.1007/978-1-4899-7478-5_706
Antibiotics: Biosynthesis, Generation of Novel Compounds 10.1002/9780470054581.eib040
Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites 10.1039/c6np00019c
The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production 10.1016/j.synbio.2015.12.002
Introduction to the Special Issue “Bioinformatic tools and approaches for Synthetic Biology of natural products” 10.1016/j.synbio.2016.04.001
CRISPy-web: An online resource to design sgRNAs for CRISPR applications 10.1016/j.synbio.2016.01.003
The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters 10.1093/nar/gkw960
Polyketide bio-derivatization using the promiscuous acyltransferase KirCII. 10.1021/acssynbio.6b00341
The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery 10.1093/nar/gkx360
antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification 10.1093/nar/gkx319
Cyanodermella asteris sp. nov. (Ostropales) from the inflorescence axis of Aster tataricus 10.5248/132.107
Dissemination of antibiotic resistance genes from antibiotic producers to pathogens 10.1038/ncomms15784
Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters 10.1093/bib/bbx146
Toward Systems Metabolic Engineering of Streptomycetes for Secondary Metabolites Production. 10.1002/biot.201700465
Linking secondary metabolites to biosynthesis genes in the fungal endophyte Cyanodermella asteris: The anti-cancer bisanthraquinone skyrin. 10.1016/j.jbiotec.2017.06.410
CRISPR-Cas9 Toolkit for Actinomycete Genome Editing. 10.1007/978-1-4939-7295-1_11
Recent development of computational resources for new antibiotics discovery. 10.1016/j.mib.2017.10.027
Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions 10.1038/s41598-018-21507-6
Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms 10.1016/j.mib.2018.03.004
Patscanui: an intuitive web interface for searching patterns in DNA and protein data 10.1093/nar/gky321
Lysoquinone-TH1, a New Polyphenolic Tridecaketide Produced by Expressing the Lysolipin Minimal PKS II in Streptomyces albus 10.3390/antibiotics7030053
Discrete acyltransferases involved in polyketide biosynthesis 10.1039/c2md20048a
Improved Lanthipeptide Detection and Prediction for antiSMASH 10.1371/journal.pone.0089420
Genome-Scale Metabolic Reconstruction of Actinomycetes for Antibiotics Production 10.1002/biot.201800377
The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters 10.1093/nar/gky1060
CRISPR/Cas-based genome engineering in natural product discovery 10.1039/C8NP00089A
Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH 10.1007/s10295-018-02131-9
Synthetic biology and metabolic engineering of actinomycetes for natural product discovery 10.1016/j.biotechadv.2019.03.005
Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001 10.1101/577817
CRISPR-BEST: a highly efficient DSB-free base editor for filamentous actinomycetes 10.1101/582403
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline 10.1093/nar/gkz310
Genome Mining Approaches to Bacterial Natural Product Discovery 10.1016/b978-0-12-409547-2.14627-x
Engineering of cell factories for the production of natural products 10.1039/C9NP90036E
Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST 10.1073/pnas.1913493116
Pangenome Analysis of Enterobacteria Reveals Richness of Secondary Metabolite Gene Clusters and their Associated Gene Sets 10.1101/781328
Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001. 10.1016/j.synbio.2019.08.002
The Draft Whole-Genome Sequence of the Antibiotic Producer Empedobacter haloabium ATCC 31962 Provides Indications for Its Taxonomic Reclassification. 10.1128/mra.01120-19
MIBiG 2.0: a repository for biosynthetic gene clusters of known function. 10.1093/nar/gkz882
Versatile polyketide biosynthesis platform for production of aromatic compounds in yeast 10.1101/618751
Antitumor astins originate from the fungal endophyteCyanodermella asterisliving within the medicinal plantAster tataricus 10.1073/pnas.1910527116
Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast. 10.1016/j.synbio.2020.01.004
Complete Genome Sequences of 13 Bacillus subtilis Soil Isolates for Studying Secondary Metabolite Diversity. 10.1128/MRA.01406-19
ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining 10.1093/nar/gkaa374
Designing sgRNAs for CRISPR-BEST base editing applications with CRISPy-web 2.0 10.1016/j.synbio.2020.05.005
CRISPR–Cas9, CRISPRi and CRISPR-BEST-mediated genetic manipulation in streptomycetes 10.1038/s41596-020-0339-z
Distribution of Epsilon-Polylysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin 10.1101/2020.07.24.220772
Genomic and chemical diversity of Bacillus subtilis secondary metabolites against plant pathogenic fungi 10.1101/2020.08.05.238063
CRISPR-nRAGE, a Cas9 nickase-reverse transcriptase assisted versatile genetic engineering toolkit for E. coli 10.1101/2020.09.02.279141
BiG-FAM: the biosynthetic gene cluster families database 10.1093/nar/gkaa812
Phylogenetic distribution of secondary metabolites in the Bacillus subtilis species complex 10.1101/2020.10.28.358507
The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes 10.1093/nar/gkaa978
Characterization and Engineering of Streptomyces griseofuscus DSM 40191 as a Potential Host for Heterologous Expression of Biosynthetic Gene Clusters 10.1101/2020.11.06.372458
High-Quality Sequencing, Assembly, and Annotation of the Streptomyces griseofuscus DSM 40191 Genome 10.1128/MRA.01100-20
Automating Cloning by Natural Transformation 10.1021/acssynbio.0c00240
Genomic and Chemical Diversity of Bacillus subtilis Secondary Metabolites against Plant Pathogenic Fungi 10.1128/mSystems.00770-20
Distribution of ε-Poly- l -Lysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin 10.1128/AEM.01841-20
Phylogenetic Distribution of Secondary Metabolites in the Bacillus subtilis Species Complex 10.1128/mSystems.00057-21
Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines 10.1007/s12257-020-0265-5
The Design-Build-Test-Learn cycle for metabolic engineering of Streptomycetes 10.1042/EBC20200132
antiSMASH 6.0: improving cluster detection and comparison capabilities 10.1093/nar/gkab335
Complete Genome Sequence of Streptomyces sp. Strain CA-256286 10.1128/MRA.00290-21
A Regulator Based “Semi-Targeted” Approach to Activate Silent Biosynthetic Gene Clusters 10.3390/ijms22147567
Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp. Strain CA-103260 10.1128/MRA.00499-21
Towards the sustainable discovery and development of new antibiotics 10.1038/s41570-021-00313-1
A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing 10.1038/s41467-021-25541-3
Computational Applications in Secondary Metabolite Discovery (CAiSMD): an online workshop. 10.1186/s13321-021-00546-8
Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260. 10.1021/acschembio.1c00318
Emmanuel de los Santos
de los Santos Emmanuel / Emmanuel LC de los Santos / Emzo de los Santos
ORCID: 0000-0002-9496-9407
Engineering Transcriptional Regulator Effector Specificity Using Computational Design and In Vitro Rapid Prototyping: Developing a Vanillin Sensor 10.1021/acssynbio.5b00090
Design and Implementation of a Biomolecular Concentration Tracker 10.1021/sb500024b
Design and implementation of a biomolecular circuit for tracking protein concentration 10.1109/ACC.2013.6580175
Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis 10.1039/c6sc02803a
Mechanistic insights into class B radical-S-adenosylmethionine methylases: ubiquitous tailoring enzymes in natural product biosynthesis 10.1016/j.cbpa.2016.08.021
Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor 10.1186/s13036-017-0071-6
AntiSMASH 4.0 - improvements in chemistry prediction and gene cluster boundary identification 10.1093/nar/gkx319
Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis 10.1039/c8np00004b
clusterTools: Proximity Searches For Functional Elements To Identify Putative Biosynthetic Gene Clusters 10.1101/119214
Engineering Transcriptional Regulator Effector Specificity using Computational Design and In Vitro Rapid Prototyping: Developing a Vanillin Sensor 10.1101/015438
Design and implementation of a synthetic biomolecular concentration tracker 10.1101/000448
Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group 10.1021/acschembio.9b00270
The antiSMASH database version 2: A comprehensive resource on secondary metabolite biosynthetic gene clusters 10.1093/nar/gky1060
NeuRiPP: Neural network identification of RiPP precursor peptides 10.1101/616060
Francesco Del Carratore
Del Carratore Francesco
ORCID: 0000-0003-1647-7818
Output Ordering and Prioritisation System (OOPS) 10.1007/s10295-017-1993-1
Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters 10.1038/s42003-019-0333-6
The antiSMASH database version 2: A comprehensive resource on secondary metabolite biosynthetic gene clusters 10.1093/nar/gky1060
1H NMR spectroscopy-based metabolomics analysis for the diagnosis of symptomatic E. coli-associated urinary tract infection (UTI) 10.1186/s12866-017-1108-1
Translation stress positively regulates mscl-dependent excretion of cytoplasmic proteins 10.1128/mBio.02118-17
Metabolomics as a Tool for the characterization of Drug-resistant epilepsy 10.3389/fneur.2017.00459
1H-NMR analysis provides a metabolomic profile of patients with multiple sclerosis 10.1212/NXI.0000000000000185
Statistical Health Monitoring Applied to a Metabolomic Study of Experimental Hepatocarcinogenesis: An Alternative Approach to Supervised Methods for the Identification of False Positives 10.1021/acs.analchem.5b03078
RankProd 2.0: a refactored bioconductor package for detecting differentially expressed features in molecular profiling datasets 10.1093/bioinformatics/btx292
Integrated Probabilistic Annotation (IPA) 10.1021/acs.analchem.9b02354
Synthetic biology approaches to actinomycete strain improvement 10.1093/femsle/fnab060
Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation 10.1096/fj.201901501R
Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation 10.1096/fj.201901501R PDF
Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor 10.3389/fbioe.2020.595552
Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A 10.1128/mSystems.00341-21
Marnix H. Medema
Medema Marnix H.
ORCID: 0000-0002-2191-2821
Bioinformatics Approaches and Software for Detection of Secondary Metabolic Gene Clusters 10.1007/978-1-62703-122-6_2
Synthetic Biology in Streptomyces Bacteria 10.1016/b978-0-12-385075-1.00021-4
Computational approaches to natural product discovery 10.1038/nchembio.1884
Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms 10.1038/nrmicro2478
A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis 10.1371/journal.pcbi.1004016
Comparative genome-scale metabolic modeling of actinomycetes: The topology of essential core metabolism 10.1016/j.febslet.2011.06.014
MultiMetEval: Comparative and Multi-Objective Analysis of Genome-Scale Metabolic Models 10.1371/journal.pone.0051511
The future of industrial antibiotic production: From random mutagenesis to synthetic biology 10.4161/bbug.2.4.16114
Metabolomics methods for the synthetic biology of secondary metabolism 10.1016/j.febslet.2012.02.008
Computational tools for the synthetic design of biochemical pathways 10.1038/nrmicro2717
A predicted physicochemically distinct sub-proteome associated with the intracellular organelle of the anammox bacterium Kuenenia stuttgartiensis 10.1186/1471-2164-11-299
Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus 10.1111/j.1751-7915.2010.00226.x
Denitrifying bacteria anaerobically oxidize methane in the absence of Archaea 10.1111/j.1462-2920.2008.01724.x
Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters 10.1016/j.cell.2014.06.034
Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products 10.1371/journal.pcbi.1003822
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters 10.1093/nar/gkv437
Design-based re-engineering of biosynthetic gene clusters: plug-and-play in practice 10.1016/j.copbio.2013.03.006
Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block 10.1021/sb500368w
antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers 10.1093/nar/gkt449
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences 10.1093/nar/gkr466
The Sequence of a 1.8-Mb Bacterial Linear Plasmid Reveals a Rich Evolutionary Reservoir of Secondary Metabolic Pathways 10.1093/gbe/evq013
MS/MS networking guided analysis of molecule and gene cluster families 10.1073/pnas.1303471110
Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast 10.1093/molbev/mst025
Complete Genome Sequence of the Frog Pathogen Mycobacterium ulcerans Ecovar Liflandii 10.1128/jb.02132-12
NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity 10.1093/nar/gkr323
Mechanisms and Evolution of Control Logic in Prokaryotic Transcriptional Regulation 10.1128/mmbr.00037-08
Genomic mutational analysis of the impact of the classical strain improvement program on β-lactam producing Penicillium chrysogenum. 10.1186/s12864-015-2154-4
Leucanicidin and endophenasides result from methyl-rhamnosylation by the same tailoring enzymes in Kitasatospora sp. MBT66 10.1021/acschembio.5b00801
Computational strategies for genome-based natural product discovery and engineering in fungi 10.1016/j.fgb.2016.01.006
The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters 10.1093/nar/gkw960
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides 10.1038/nmicrobiol.2016.197
Editorial: Synthetic biology and bioinformatics 10.1039/c6np90031c
plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters 10.1093/nar/gkx305
Genome-based exploration of the specialized metabolic capacities of the genus Rhodococcus 10.1186/s12864-017-3966-1
Mining prokaryotes for antimicrobial compounds: from diversity to function 10.1093/femsre/fux014
Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters 10.1093/bib/bbx146
Standardization for natural product synthetic biology 10.1039/c6np00030d
Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways 10.1039/c6np00035e
Draft Genome Sequence of a Porcine Commensal, Rothia nasimurium , Encoding a Nonribosomal Peptide Synthetase Predicted To Produce the Ionophore Antibiotic Valinomycin 10.1128/genomea.00453-17
SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria 10.1093/bioinformatics/btx400
Collaborating with Undergraduates To Contribute to Biochemistry Community Resources 10.1021/acs.biochem.7b00872
Road MAPs to engineer host microbiomes. 10.1016/j.mib.2017.11.023
Genome-wide analysis of bacterial determinants of plant growth promotion and induced systemic resistance by Pseudomonas fluorescens. 10.1111/1462-2920.13927
Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveals convergent evolution. 10.1073/pnas.1705567114
antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification. 10.1093/nar/gkx319
Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products. 10.1016/j.fgb.2016.01.012
Exploration and exploitation of the environment for novel specialized metabolites. 10.1016/j.copbio.2018.01.017
Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology 10.1128/mSystems.00182-17
Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics. 10.1016/j.chembiol.2018.02.008
HEx: A heterologous expression platform for the discovery of fungal natural products. 10.1126/sciadv.aar5459
luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria. 10.1128/msystems.00208-17
A Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology. 10.1021/jacs.7b13292
Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium. 10.3389/fmicb.2018.01158
Involvement of Burkholderiaceae and sulfurous volatiles in disease-suppressive soils. 10.1038/s41396-018-0186-x
Genomic Identification and Analysis of Specialized Metabolite Biosynthetic Gene Clusters in Plants Using PlantiSMASH. 10.1007/978-1-4939-7874-8_15
A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene cluster (MIBiG) repository: prospects for research-based educational experiences 10.1186/s40793-018-0318-y
The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters 10.1093/nar/gky1060
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1101/463620
Mining bacterial genomes to reveal secret synergy 10.1074/jbc.H118.006669
Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters 10.1038/s42003-019-0333-6
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1111/tpj.14292
A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters 10.1186/s13104-019-4222-3
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline 10.1093/nar/gkz310
MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools 10.1101/654459
BiosyntheticSPAdes: Reconstructing Biosynthetic Gene Clusters From Assembly Graphs 10.1101/gr.243477.118
Genome Mining Approaches to Bacterial Natural Product Discovery 10.1016/b978-0-12-409547-2.14627-x
Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines 10.1039/C9NP00021F
PlantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters 10.1101/083535
MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools 10.3390/metabo9070144
Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L. 10.3389/fpls.2019.00846
Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome 10.1126/science.aaw9285
MIBiG 2.0: a repository for biosynthetic gene clusters of known function 10.1093/nar/gkz882
A metabolic pathway for bile acid dehydroxylation by the gut microbiome 10.1101/758557
Coevolution-based prediction of protein-protein interactions in polyketide biosynthetic assembly lines 10.1101/669291
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery 10.1021/acscentsci.9b00806
Cultivation and functional characterization of 79 planctomycetes uncovers their unique biology 10.1038/s41564-019-0588-1
Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia 10.1101/856955
Drivers of metabolic diversification: how dynamic genomic neighbourhoods generate new biosynthetic pathways in the Brassicaceae 10.1111/nph.16338
Microbial and volatile profiling of soils suppressive to Fusarium culmorum of wheat 10.1098/rspb.2019.2527
Computational genomic discovery of diverse gene clusters harboring Fe-S flavoenzymes in anaerobic gut microbiota 10.1101/2020.03.06.976126
RRE-Finder: A Genome-Mining Tool for Class-Independent RiPP Discovery 10.1101/2020.03.14.992123
Linking genomics and metabolomics to chart specialized metabolic diversity 10.1039/D0CS00162G
Computational genomic discovery of diverse gene clusters harbouring Fe-S flavoenzymes in anaerobic gut microbiota 10.1099/mgen.0.000373
ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining 10.1093/nar/gkaa374
Integration of machine learning and pan-genomics expands the biosynthetic landscape of RiPP natural products 10.1101/2020.05.19.104752
Ecology and genomics of Actinobacteria: new concepts for natural product discovery 10.1038/s41579-020-0379-y
The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms 10.1038/s42003-020-0993-2
BiG-SLiCE: A Highly Scalable Tool Maps the Diversity of 1.2 Million Biosynthetic Gene Clusters 10.1101/2020.08.17.240838
Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia 10.1074/jbc.RA120.013528
Microbial natural product databases: moving forward in the multi-omics era 10.1039/D0NP00053A
Author Correction: The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms 10.1038/s42003-020-01228-1
RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery 10.1128/mSystems.00267-20
Author Correction: The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms 10.1038/s42003-020-01271-y
BiG-FAM: the biosynthetic gene cluster families database 10.1093/nar/gkaa812
Coevolution-based prediction of protein–protein interactions in polyketide biosynthetic assembly lines 10.1093/bioinformatics/btaa595
The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes 10.1093/nar/gkaa978
Pan-genome analysis and ancestral state reconstruction of class halobacteria: probability of a new super-order 10.1038/s41598-020-77723-6
BiG-MAP: an automated pipeline to profile metabolic gene cluster abundance and expression in microbiomes 10.1101/2020.12.14.422671
Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides 10.1371/journal.pbio.3001026
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters 10.1093/gigascience/giaa154
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases 10.1039/D0NP00090F
Do size and shape matter? Exploring the interactions and the metabolome of the soil isolate Hylemonella gracilis 10.1101/2021.02.11.430889
A systematic analysis of metabolic pathways in the human gut microbiota 10.1101/2021.02.25.432841
Omics-based strategies to discover novel classes of RiPP natural products 10.1016/j.copbio.2020.12.008
Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria 10.1038/s41467-021-21163-x
The Surfactin-Like Lipopeptides From Bacillus spp.: Natural Biodiversity and Synthetic Biology for a Broader Application Range 10.3389/fbioe.2021.623701
Mining metagenomes for natural product biosynthetic gene clusters: unlocking new potential with ultrafast techniques 10.1101/2021.01.20.427441
Extracting the GEMs: Genotype, Environment, and Microbiome Interactions Shaping Host Phenotypes 10.3389/fmicb.2020.574053
A mammalian commensal of the oropharyngeal cavity produces antibiotic and antiviral valinomycin in vivo 10.21203/rs.3.rs-126949/v1
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters 10.1016/j.chembiol.2020.11.009
cblaster: a remote search tool for rapid identification and visualisation of homologous gene clusters 10.1101/2020.11.08.370601
antiSMASH 6.0: improving cluster detection and comparison capabilities 10.1093/nar/gkab335
The gutSMASH web server: automated identification of primary metabolic gene clusters from the gut microbiota 10.1093/nar/gkab353
Mining genomes to illuminate the specialized chemistry of life 10.1038/s41576-021-00363-7
Dominant drivers of the human plasma metabolome 10.21203/rs.3.rs-688716/v1
A global survey of specialized metabolic diversity encoded in bacterial genomes 10.1101/2021.08.11.455920
cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters 10.1093/bioadv/vbab016
Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran