ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining
Mehmet Direnç Mungan Mohammad Alanjary Kai Blin Tilmann Weber Marnix H. Medema Nadine Ziemert
Kai Blin
Blin Kai
ORCID: 0000-0003-3764-6051
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Proteomic approach to reveal the regulatory function of aconitase AcnA in oxidative stress response in the antibiotic producer Streptomyces viridochromogenes Tu494. 10.1371/journal.pone.0087905
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plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters 10.1093/nar/gkx305
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The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes 10.1093/nar/gkaa978
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A Regulator Based “Semi-Targeted” Approach to Activate Silent Biosynthetic Gene Clusters 10.3390/ijms22147567
Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260 10.1021/acschembio.1c00318
Tilmann Weber
Weber Tilmann
ORCID: 0000-0002-8260-5120
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Designing sgRNAs for CRISPR-BEST base editing applications with CRISPy-web 2.0 10.1016/j.synbio.2020.05.005
CRISPR–Cas9, CRISPRi and CRISPR-BEST-mediated genetic manipulation in streptomycetes 10.1038/s41596-020-0339-z
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Marnix H. Medema
Medema Marnix H.
ORCID: 0000-0002-2191-2821
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BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters 10.1093/gigascience/giaa154
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases 10.1039/D0NP00090F
Do size and shape matter? Exploring the interactions and the metabolome of the soil isolate Hylemonella gracilis 10.1101/2021.02.11.430889
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Omics-based strategies to discover novel classes of RiPP natural products 10.1016/j.copbio.2020.12.008
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The Surfactin-Like Lipopeptides From Bacillus spp.: Natural Biodiversity and Synthetic Biology for a Broader Application Range 10.3389/fbioe.2021.623701
Mining metagenomes for natural product biosynthetic gene clusters: unlocking new potential with ultrafast techniques 10.1101/2021.01.20.427441
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antiSMASH 6.0: improving cluster detection and comparison capabilities 10.1093/nar/gkab335
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Mining genomes to illuminate the specialized chemistry of life 10.1038/s41576-021-00363-7
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A global survey of specialized metabolic diversity encoded in bacterial genomes 10.1101/2021.08.11.455920
cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters 10.1093/bioadv/vbab016
Nadine Ziemert
Ziemert Nadine
ORCID: 0000-0002-7264-1857
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Antibiotic drug discovery 10.1111/1751-7915.12388
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Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules 10.1073/pnas.1315492110
Challenges and triumphs to genomics-based natural product discovery 10.1007/s10295-013-1353-8
The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity 10.1371/journal.pone.0034064
Phylogenetic approaches to natural product structure prediction 10.1016/b978-0-12-404634-4.00008-5
Leader peptide and a membrane protein scaffold guide the biosynthesis of the tricyclic peptide microviridin 10.1016/j.chembiol.2011.09.011
Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides 10.1128/aem.02858-09
Highly plastic genome of Microcystis aeruginosa PCC 7806, a ubiquitous toxic freshwater cyanobacterium 10.1186/1471-2164-9-274
Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa 10.1128/aem.02392-07
Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria 10.1002/anie.200802730
Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species 10.1186/s12864-018-4809-4
Applied evolution: phylogeny-based approaches in natural products research 10.1039/C9NP00027E
ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining 10.1093/nar/gkaa374
Comparative Genomics and Metabolomics in the Genus Nocardia 10.1128/mSystems.00125-20
The genus Micromonospora as a model microorganism for bioactive natural product discovery 10.1039/D0RA04025H
Modular Fragment Synthesis and Bioinformatic Analysis Propose a Revised Vancoresmycin Stereoconfiguration 10.1021/acs.orglett.0c03957
SYN-View: A Phylogeny-Based Synteny Exploration Tool for the Identification of Gene Clusters Linked to Antibiotic Resistance 10.3390/molecules26010144
Understanding condensation domain selectivity in non-ribosomal peptide biosynthesis: structural characterization of the acceptor bound state 10.21203/rs.3.rs-125509/v1
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline 10.1093/nar/gkz310
Analysis of the Genome and Metabolome of Marine Myxobacteria Reveals High Potential for Biosynthesis of Novel Specialized Metabolites 10.1038/s41598-018-34954-y
The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery 10.1093/nar/gkx360
Genomic insights into specialized metabolism in the marine actinomycete Salinispora 10.1111/1462-2920.13867
New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406 10.1002/cbic.202000062
Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics 10.1038/s41467-019-10384-w
The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor 10.1128/aem.01292-19
AutoMLST: an automated web server for generating multi-locus species trees highlighting natural product potential 10.1093/nar/gkz282
Recovery of the Peptidoglycan Turnover Product Released by the Autolysin Atl in Staphylococcus aureus Involves the Phosphotransferase System Transporter MurP and the Novel 6-phospho-N-acetylmuramidase MupG 10.3389/fmicb.2018.02725
Identification of a novel aminopolycarboxylic acid siderophore gene cluster encoding the biosynthesis of ethylenediaminesuccinic acid hydroxyarginine (EDHA) 10.1039/c8mt00009c
Assessing the Efficiency of Cultivation Techniques To Recover Natural Product Biosynthetic Gene Populations from Sediment 10.1021/acschembio.8b00254
Function-related replacement of bacterial siderophore pathways 10.1038/ismej.2017.137
An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria 10.1128/msystems.00028-15
Mining Bacterial Genomes for Secondary Metabolite Gene Clusters 10.1007/978-1-4939-6634-9_2
Mining Indonesian Microbial Biodiversity for Novel Natural Compounds by a Combined Genome Mining and Molecular Networking Approach 10.20944/preprints202105.0308.v1
Mining Indonesian Microbial Biodiversity for Novel Natural Compounds by a Combined Genome Mining and Molecular Networking Approach 10.3390/md19060316
A global survey of specialized metabolic diversity encoded in bacterial genomes 10.1101/2021.08.11.455920
The confluence of big data and evolutionary genome mining for the discovery of natural products 10.1039/D1NP00013F