A yeast t-SNARE involved in endocytosis.
K Séron V Tieaho C Prescianotto-Baschong T Aust M O Blondel P Guillaud G Devilliers Olivia Rossanese B S Glick H Riezman S Keränen R Haguenauer-Tsapis
Karin Seron
Seron Karin
ORCID: 0000-0002-9667-133X
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Howard Riezman
Riezman Howard
ORCID: 0000-0003-4680-9422
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1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding 10.1038/s42255-019-0123-y
Patches and Blebs: A Comparative Study of the Composition and Biophysical Properties of Two Plasma Membrane Preparations from CHO Cells 10.3390/ijms21072643
CHO/LY-B cell growth under limiting sphingolipid supply: correlation between lipid composition and biophysical properties of sphingolipid-restricted cell membranes+ 10.1101/2020.07.05.188474
HaloFlippers: A General Tool for the Fluorescence Imaging of Precisely Localized Membrane Tension Changes in Living Cells 10.1021/acscentsci.0c00666
Phosphatidylcholines from Pieris brassicae eggs activate an immune response in Arabidopsis 10.7554/eLife.60293
Establishment of a highly efficient gene disruption strategy to analyze and manipulate lipid co-regulatory networks 10.1101/2020.11.24.395632
Receptor-linked environment-sensitive probe monitors the local membrane environment surrounding the insulin receptor 10.1101/2020.12.23.424145
Genetically Encoded Supramolecular Targeting of Fluorescent Membrane Tension Probes within Live Cells: Precisely Localized Controlled Release by External Chemical Stimulation 10.1021/jacsau.0c00069
Short Photoswitchable Ceramides Enable Optical Control of Apoptosis 10.1021/acschembio.0c00823
Luciferase Controlled Protein Interactions 10.1021/jacs.0c11016
Vacuole-specific lipid release for tracking intracellular lipid metabolism and transport in Saccharomyces cerevisiae 10.1101/2021.05.04.442581
Patched regulates lipid homeostasis by controlling cellular cholesterol levels 10.1038/s41467-021-24995-9
Olivia Rossanese
Rossanese Olivia
ORCID: 0000-0002-1262-9522
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. 10.1021/acs.jmedchem.9b02076
Role for the Histone Demethylase KDM4B in Rhabdomyosarcoma via CDK6 and CCNA2: Compensation by KDM4A and Apoptotic Response of Targeting Both KDM4B and KDM4A. 10.3390/cancers13071734
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. 10.1016/j.ejmech.2019.05.041
Assessing histone demethylase inhibitors in cells: lessons learned. 10.1186/s13072-017-0116-6
Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A. 10.1002/cmdc.201500479
Diphenylpyrazoles as replication protein a inhibitors. 10.1021/ml5003629
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design. 10.1021/jm501984f
Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods. 10.1021/acs.jmedchem.5b01660
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. 10.1002/anie.201201358
Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors. 10.1021/ml4000063
Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. 10.1021/jm401333u
A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae. 10.1083/jcb.153.1.47
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer. 10.1186/s13059-016-1042-9
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. 10.1016/j.ab.2018.01.025
Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors. 10.1002/1873-3468.12497
Investigating mechanisms of tolerance to APOBEC3B upregulation in cancer 10.1158/1538-7445.AM2020-2384
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. 10.1021/acs.jmedchem.9b01411
Small molecule-mediated modulation of Ras elicits inhibition of phospho ERK signaling through negative feedback on SOS1 10.1158/1538-7445.AM2018-865
Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS. 10.1021/acsmedchemlett.8b00296
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. 10.1021/acs.jmedchem.8b01108
Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. 10.1021/acs.jmedchem.8b00375
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling. 10.1021/acs.jmedchem.8b00360
Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1. 10.1158/1535-7163.MCT-17-0666
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design. 10.1021/acs.jmedchem.7b01155
Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines 10.1158/1538-7445.AM2016-3551
Discovery of potent 2-Indole-acylsulfonamide Mcl-1 inhibitors using structure guided fragment-based methods 10.1158/1538-7445.AM2016-4331
Stapled helix peptides as probes to evaluate targeted disruption of protein-protein interactions mediated by RPA70N. 10.1158/1538-7445.AM2013-3340
Discovery of probes to evaluate the disruption of the protein-protein interactions mediated by RPA70N 10.1158/1538-7445.AM2015-3695
Evaluation of TBK1 as a novel cancer target in the K -Ras pathway 10.1158/1538-7445.AM2012-1813
Targeting Ras with small molecules that activate SOS-mediated nucleotide exchange 10.1158/1538-7445.AM2014-4417
Optimization of a potent stapled helix peptide that binds to Replication Protein A 10.1158/1538-7445.AM2014-3232
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange 10.1158/1535-7163.TARG-13-PR01
A yeast t-SNARE involved in endocytosis. 10.1091/mbc.9.10.2873
A versatile set of vectors for constitutive and regulated gene expression in Pichia pastoris. 10.1002/(SICI)1097-0061(19980615)14:8<783::AID-YEA272>3.0.CO;2-Y
Golgi structure correlates with transitional endoplasmic reticulum organization in Pichia pastoris and Saccharomyces cerevisiae. 10.1083/jcb.145.1.69
Deconstructing Golgi inheritance. 10.1034/j.1600-0854.2001.20901.x
The functional interface between Salmonella and its host cell: opportunities for therapeutic intervention. 10.1016/j.tips.2005.09.005
The related effector proteins SopD and SopD2 from Salmonella enterica serovar Typhimurium contribute to virulence during systemic infection of mice. 10.1111/j.1365-2958.2004.04344.x
Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling. 10.1128/MCB.00567-07
A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A. 10.1016/j.ab.2011.11.025
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. 10.1016/j.bmcl.2011.06.021
Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. 10.1021/ml400032y
Golgi enlargement in Arf-depleted yeast cells is due to altered dynamics of cisternal maturation. 10.1242/jcs.140996
Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. 10.1021/jm401730y
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. 10.1073/pnas.1315798111
Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer. 10.1038/cdd.2015.73
Fragment-based discovery of inhibitors of replication protein A protein-protein interactions. 10.1158/1538-7445.AM2013-2473