Paperbase

Joanne Lemieux

Lemieux Joanne

ORCID: 0000-0003-4745-9153

High yield expression and purification of equilibrative nucleoside transporter 7 (ENT7) from Arabidopsis thaliana 10.1016/j.bbagen.2015.06.003

Production of Recombinant Rhomboid Proteases. 10.1016/bs.mie.2016.10.031

Activity Assays for Rhomboid Proteases. 10.1016/bs.mie.2016.11.002

Probing catalytic rate enhancement during intramembrane proteolysis 10.1515/hsz-2016-0124

Reversible Unfolding of Rhomboid Intramembrane Proteases 10.1016/j.bpj.2016.01.032

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory 10.1007/s00232-015-9802-0

Purification and properties of recombinant Brassica napus diacylglycerol acyltransferase 1 10.1016/j.febslet.2015.02.008

Functional implications of domain organization within prokaryotic rhomboid proteases 10.1007/978-3-319-23603-2_6

Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana 10.1016/j.bbamem.2014.08.013

Allosteric regulation of rhomboid intramembrane proteolysis 10.15252/embj.201488149

Expression and purification of Haemophilus influenzae rhomboid intramembrane protease GlpG for structural studies 10.1002/0471140864.ps2909s76

Structure-function relationship of a plant NCS1 member--homology modeling and mutagenesis identified residues critical for substrate specificity of PLUTO, a nucleobase transporter from Arabidopsis. 10.1371/journal.pone.0091343

Untangling structure-function relationships in the rhomboid family of intramembrane proteases 10.1016/j.bbamem.2013.05.003

A perspective on the structural studies of inner membrane electrochemical potential-driven transporters 10.1016/j.bbamem.2008.01.009

Insights into substrate gating in H. influenzae rhomboid 10.1016/j.jmb.2011.01.046

Crystal structure of the N-lobe of lactoferrin binding protein B from Moraxella bovis. 10.1139/o11-078

Oligomeric state study of prokaryotic rhomboid proteases 10.1016/j.bbamem.2012.08.004

Domain swapping in the cytoplasmic domain of the escherichia coli rhomboid protease 10.1016/j.jmb.2013.01.019

Rapid expression screening of eukaryotic membrane proteins in Pichia pastoris 10.1002/pro.2223

Eukaryotic major facilitator superfamily transporter modeling based on the prokaryotic GlpT crystal structure. 10.1080/09687680701496507

The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane porteolysis 10.1073/pnas.0609981104

Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. 10.1016/j.jmb.2006.04.004

Crystal structure and mechanism of GlpT, the glycerol-3-phosphate transporter from E. coli 10.1093/jmicro/54.suppl_1.i43

Glycerol-3-phosphate transporter of Escherichia coli: Structure, function and regulation 10.1016/j.resmic.2004.05.016

The structural basis of substrate translocation by the Escherichia coli glycerol-3-phosphate transporter: A member of the major facilitator superfamily 10.1016/j.sbi.2004.06.003

Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli 10.1126/science.1087619

Three-dimensional crystallization of the Escherichia coli glycerol-3-phosphate transporter: A member of the major facilitator superfamily 10.1110/ps.03276603

Importance of detergent and phospholipid in the crystallization of the human erythrocyte anion-exchanger membrane domain. 10.1016/s1047-8477(02)00010-2

High-yield expression and functional analysis of Escherichia coli glycerol-3-phosphate transporter 10.1021/bi010138+

Secretion and processing of apolipoprotein A-I in the avian sciatic nerve during development. 10.1002/(sici)1097-4547(19960615)44:6<594::aid-jnr10>3.0.co;2-z

Identification of key residues for urate specific transport in human glucose transporter 9 (hSLC2A9) 10.1038/srep41167

The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis 10.1007/s10969-005-9004-6

Biosynthesis and compartmentalization of Po, apolipoprotein A-I, and lipids in the myelinating chick sciatic nerve 10.1007/BF00995389

The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences 10.1107/S2053230X14019372

Structural comparison of substrate entry gate for rhomboid intramembrane peptidases 10.1139/O10-161

Critical roles of two hydrophobic residues within human glucose transporter 9 (hSLC2A9) in substrate selectivity and urate transport 10.1074/jbc.M114.611178

Practical aspects of overexpressing bacterial secondary membrane transporters for structural studies 10.1016/S0005-2736(02)00709-5

Regulation of 2′,3′-cyclic nucleotide phosphodiesterase gene expression in experimental peripheral neuropathies 10.1016/0169-328X(92)90149-6

Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1 10.1042/BJ20030884

Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides 10.1021/acschembio.6b01101

Post-translational modifications of apolipoprotein A-I and Po proteins in the avian peripheral nerve 10.1007/BF00969542

Diacylglycerol Acyltransferase 1 Is Regulated by Its N-Terminal Domain in Response to Allosteric Effectors 10.1104/pp.17.00934

Multiple mechanisms contribute to increased neutral lipid accumulation in yeast producing recombinant variants of plant diacylglycerol acyltransferase 1. 10.1074/jbc.m117.811489

Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry 10.1074/mcp.TIR118.001099

Reactions at Biomembrane Interfaces 10.1021/acs.chemrev.8b00596

PARL Protease: A Glimpse at Intramembrane Proteolysis in the Inner Mitochondrial Membrane. 10.1016/j.jmb.2020.04.006

Interaction of a Sarcolipin Pentamer and Monomer with the Sarcoplasmic Reticulum Calcium Pump, SERCA. 10.1016/j.bpj.2019.11.3385

Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR. 10.1093/nar/gkz891

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. 10.1038/s41598-019-48826-6

Targeting B7-1 in immunotherapy. 10.1002/med.21632

Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f. 10.1002/1873-3468.13565

Sarcolambans are phospholamban- and sarcolipin-like regulators of the sarcoplasmic reticulum calcium pump SERCA 10.1101/2020.07.19.211243

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. 10.1038/s41467-020-18096-2

Structure and function of proteins in membranes and nanodiscs. 10.1016/j.bbamem.2020.183445

Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel. 10.1113/jp279961

Photocleavable proteins that undergo fast and efficient dissociation 10.1039/D1SC01059J

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability. 10.1021/acs.jmedchem.1c00616

Improved SARS-CoV-2 M^pro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies. 10.1016/j.ejmech.2021.113584

Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA. 10.7554/elife.65545

N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 M^pro Dimer. 10.1016/j.jmb.2021.167003

Expression and Purification of Human Mitochondrial Intramembrane Protease PARL. 10.1007/978-1-0716-1394-8_1

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL. 10.1016/j.jbc.2021.100383

Anthony O'Donoghue

O'Donoghue Anthony

ORCID: 0000-0001-5695-0409

Validation of Babesia proteasome as a drug target 10.1016/j.ijpddr.2018.08.001

A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro 10.1021/acschembio.8b00420

Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology 10.1021/acs.jmedchem.8b01536

Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry 10.1074/mcp.TIR118.001099

20S Proteasome as a Drug Target in Trichomonas vaginalis 10.1128/AAC.00448-19

Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant 10.1021/acsomega.9b02491

Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses 10.1074/mcp.RA120.002079

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma 10.3390/molecules25184071

A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding 10.1126/science.abb7709

Activatable Carbocyanine Dimers for Photoacoustic and Fluorescent Detection of Protease Activity 10.1021/acssensors.1c00518

Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing 10.1021/acschemneuro.1c00133

Steven Wang

Wang Steven

ORCID: 0000-0001-5126-9577

Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis. 10.1002/cmdc.201800404

Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry. 10.1074/mcp.tir118.001099

Zhenze Jiang

Jiang Zhenze

ORCID: 0000-0001-9570-1739

Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry 10.1074/mcp.TIR118.001099

The Pseudomonas aeruginosa protease LasB directly activates IL-1 beta 10.1016/J.EBIOM.2020.102984

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma 10.3390/MOLECULES25184071

Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses 10.1074/MCP.RA120.002079

Engineering of multiple trypsin/chymotrypsin sites in Cry3A to enhance its activity against Monochamus alternatus Hope larvae 10.1002/PS.5866

20S Proteasome as a Drug Target in Trichomonas vaginalis 10.1128/AAC.00448-19

The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni 10.1021/ACSINFECDIS.9B00237

Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoascus destructans, the causal agent of White-nose Syndrome 10.1515/HSZ-2018-0240

An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases 10.1515/HSZ-2018-0255

A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro 10.1021/ACSCHEMBIO.8B00420

Skin Commensal Malassezia globosa Secreted Protease Attenuates Staphylococcus aureus Biofilm Formation 10.1016/J.JID.2017.11.034

Targeting proteasomes in infectious organisms to combat disease 10.1111/FEBS.14029

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties 10.1371/JOURNAL.PNTD.0006446

An enzyme-free signal amplification strategy for sensitive detection of microRNA via catalyzed hairpin assembly 10.1039/C4AY02142H

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL 10.1016/J.JBC.2021.100383

Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing 10.1021/acschemneuro.1c00133

Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions 10.1021/acschembio.1c00138

Jacob Wozniak

Wozniak Jacob

ORCID: 0000-0002-2453-0861

Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function 10.1073/pnas.1917295117

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules 10.1016/j.cell.2017.12.032

American Gut: an Open Platform for Citizen Science Microbiome Research 10.1128/msystems.00031-18

Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr 10.1074/mcp.m116.066019

Defining Host Responses during Systemic Bacterial Infection through Construction of a Murine Organ Proteome Atlas 10.1016/j.cels.2018.04.010

Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290

Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry 10.1074/mcp.tir118.001099

Optimization of carbon and energy utilization through differential translational efficiency 10.1038/s41467-018-06993-6

EGFR is required for Wnt9a–Fzd9b signalling specificity in haematopoietic stem cells 10.1038/s41556-019-0330-5

Organ-level protein networks as a reference for the host effects of the microbiome 10.1101/gr.256875.119

Quantitative analysis of Mycobacterium avium subsp. hominissuis proteome in response to antibiotics and during exposure to different environmental conditions 10.1186/s12014-019-9260-2

AssessORF: combining evolutionary conservation and proteomics to assess prokaryotic gene predictions 10.1093/bioinformatics/btz714

PTMphinder: an R package for PTM site localization and motif extraction from proteomic datasets 10.7717/peerj.7046

Functional and Proteomic Analysis of Streptococcus pyogenes Virulence Upon Loss of Its Native Cas9 Nuclease 10.3389/fmicb.2019.01967

Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways 10.1371/journal.pntd.0007980

Mortality Risk Profiling of Staphylococcus aureus Bacteremia by Multi-omic Serum Analysis Reveals Early Predictive and Pathogenic Signatures 10.1016/j.cell.2020.07.040

CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly 10.1073/pnas.2018251118

Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption 10.1126/scisignal.abc1044