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Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway

Seron, K. Couturier, C. Belouzard, S. Bacart, J. Monte, D. Corset, L. Bocquet, O. Dam, J. Vauthier, V. Lecoeur, C. Bailleul, B. Hoflack, B. Froguel, P. Jockers, R. Rouille, Y.

Journal of Biological Chemistry, 2011

https://doi.org/10.1074/jbc.M111.224857

Sandrine Belouzard

Belouzard Sandrine

ORCID: 0000-0002-9972-4054

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Identification of class II ADP-ribosylation factors as cellular factors required for hepatitis C virus replication 10.1111/cmi.12572

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Characterization of Hepatitis C Virus Interaction with Heparan Sulfate Proteoglycans 10.1128/JVI.03647-14

Claudin-6 and Occludin Natural Variants Found in a Patient Highly Exposed but Not Infected with Hepatitis C Virus (HCV) Do Not Confer HCV Resistance In Vitro 10.1371/journal.pone.0142539

New Insights into the Understanding of Hepatitis C Virus Entry and Cell-to-Cell Transmission by Using the Ionophore Monensin A 10.1128/JVI.00192-15

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/JVI.01473-15

Regulation of core expression during the hepatitis C virus life cycle 10.1099/vir.0.070433-0

Successful Anti-Scavenger Receptor Class B Type I (SR-BI) Monoclonal Antibody Therapy in Humanized Mice After Challenge With HCV Variants With In Vitro Resistance to SR-BI-Targeting Agents 10.1002/hep.27196

Hepatitis C Virus Replication and Golgi Function in Brefeldin A-Resistant Hepatoma-Derived Cells 10.1371/journal.pone.0074491

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Role of low-density lipoprotein receptor in the hepatitis C virus life cycle 10.1002/hep.25501

Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway 10.1074/jbc.M111.224857

Griffithsin Has Antiviral Activity against Hepatitis C Virus 10.1128/AAC.00633-11

Hepatitis C virus entry into the hepatocyte 10.2478/s11535-011-0076-y

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Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway. 10.1074/jbc.m400508200

Regulation of hepatitis C virus polyprotein processing by signal peptidase involves structural determinants at the p7 sequence junctions. 10.1074/jbc.m406315200

Bovine viral diarrhea virus entry is dependent on clathrin-mediated endocytosis. 10.1128/jvi.79.16.10826-10829.2005

Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis. 10.1038/sj.emboj.7600989

Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus. 10.1128/jvi.80.6.2832-2841.2006

Entry and release of hepatitis C virus in polarized human hepatocytes. 10.1128/JVI.00478-17

Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes 10.1053/j.gastro.2018.03.020

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Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483

Secretory Vesicles Are the Principal Means of SARS-CoV-2 Egress. 10.3390/cells10082047

Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral Replication. 10.1128/aac.00097-21

didier monte

monte didier

ORCID: 0000-0002-0613-6203

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Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway 10.1074/jbc.M111.224857

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ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease 10.1007/s00109-007-0299-6

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Take Your PIC 10.1016/j.tibs.2021.05.008

Yves Rouillé

Rouillé Yves

ORCID: 0000-0003-0788-9271

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EVOLUTIONARY SPECIFICITY OF HYDRINS, NEW HYDROOSMOTIC NEUROPEPTIDES - OCCURRENCE OF HYDRIN-2 (VASOTOCINYL-GLY) IN THE TOAD BUFO-MARINUS BUT NOT IN THE VIPER VIPERA-ASPIS 10.1016/0014-5793(90)80783-f

IDENTIFICATION OF 2 TYPES OF NEUROPHYSINS IN XENOPUS-LAEVIS NEUROINTERMEDIATE PITUITARY HOMOLOGOUS TO MAMMALIAN MSEL-NEUROPHYSIN AND VLDV-NEUROPHYSIN 10.1016/0143-4179(90)90142-l

OCCURRENCE OF HYDRIN-2 (VASOTOCINYL-GLY), A NEW HYDROOSMOTIC NEUROHYPOPHYSEAL PEPTIDE, IN SECRETORY GRANULES ISOLATED FROM THE FROG (RANA-ESCULENTA) NEUROINTERMEDIATE PITUITARY 10.1159/000125343

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PARTICULAR PROCESSING OF PRO-OPIOMELANOCORTIN IN XENOPUS-LAEVIS INTERMEDIATE PITUITARY - SEQUENCING OF ALPHA-MELANOCYTE-STIMULATING, AND BETA-MELANOCYTE-STIMULATING HORMONES 10.1016/0014-5793(89)80224-8

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Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal 10.1210/me.2015-1211

Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus 10.1128/jvi.00404-16

Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5

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New Insights into the Understanding of Hepatitis C Virus Entry and Cell-to-Cell Transmission by Using the Ionophore Monensin A 10.1128/jvi.00192-15

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15

Regulation of core expression during the hepatitis C virus life cycle 10.1099/vir.0.070433-0

FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver 10.1186/1478-811x-12-4

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Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022

Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors 10.1016/j.bmcl.2014.07.051

Hepatitis C Virus Replication and Golgi Function in Brefeldin A-Resistant Hepatoma-Derived Cells 10.1371/journal.pone.0074491

(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry 10.1002/hep.24803

Hepatitis C Virus and Natural Compounds: A New Antiviral Approach? 10.3390/v4102197

Role of low-density lipoprotein receptor in the hepatitis C virus life cycle 10.1002/hep.25501

Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway 10.1074/jbc.M111.224857

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Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity 10.1073/pnas.0706671104

Hepatitis C virus entry depends on clathrin-mediated endocytosis 10.1128/jvi.00024-06

Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus 10.1128/jvi.80.6.2832-2841.2006

Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis 10.1038/sj.emboj.7600989

Bovine viral diarrhea virus entry is dependent on clathrin-mediated endocytosis 10.1128/jvi.79.16.10826-10829.2005

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Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483

Secretory Vesicles Are the Principal Means of SARS-CoV-2 Egress 10.3390/cells10082047

Karin Seron

Seron Karin

ORCID: 0000-0002-9667-133X

Identification of class II ADP-ribosylation factors as cellular factors required for hepatitis C virus replication 10.1111/cmi.12572

Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5

Characterization of Hepatitis C Virus Interaction with Heparan Sulfate Proteoglycans 10.1128/jvi.03647-14

Claudin-6 and Occludin Natural Variants Found in a Patient Highly Exposed but Not Infected with Hepatitis C Virus (HCV) Do Not Confer HCV Resistance In Vitro 10.1371/journal.pone.0142539

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15

Identification of Conserved Residues in Hepatitis C Virus Envelope Glycoprotein E2 That Modulate Virus Dependence on CD81 and SRB1 Entry Factors 10.1128/jvi.01402-14

Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022

Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors 10.1016/j.bmcl.2014.07.051

(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry 10.1002/hep.24803

Hepatitis C Virus and Natural Compounds: A New Antiviral Approach? 10.3390/v4102197

Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway 10.1074/jbc.M111.224857

Identification of a dominant endoplasmic reticulum-retention signal in yellow fever virus pre-membrane protein 10.1099/vir.0.015339-0

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity 10.1073/pnas.0706671104

ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity 10.2337/diabetes.55.02.06.db05-0971

Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women 10.1016/j.bbrc.2006.07.068

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GAD2 on chromosome 10p12 is a candidate gene for human obesity 10.1371/journal.pbio.0000068

Molecular cloning, functional complementation in Saccharomyces cerevisiae and enzymatic properties of phosphatidylinositol synthase from the protozoan parasite Toxoplasma gondii 10.1046/j.1432-1327.2000.01749.x

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Efficient transcription obtained by a new procedure of the tRNA-like structure of turnip yellow mosaic virus by a template-dependent and specific viral RNA polymerase 10.1016/s0166-0934(96)02166-0

Efficient transcription obtained by a new procedure of the tRNA-like structure of turnip yellow mosaic virus by a template-dependent and specific viral RNA polymerase (vol 64, pg 181, 1997) 10.1016/s0166-0934(96)02249-5

Expression of the 69K movement protein of turnip yellow mosaic virus in insect cells 10.1006/viro.1996.0246

Gene expression from viral RNA genomes 10.1007/bf00039391

Vascular movement of plant viruses 10.1094/mpmi-9-0435

IN-VITRO TRANSCRIPTS OF TURNIP YELLOW MOSAIC-VIRUS ENCOMPASSING A LONG 3' EXTENSION OR PRODUCED FROM A FULL-LENGTH CDNA CLONE HARBORING A 2 KB-LONG PCR-AMPLIFIED SEGMENT ARE INFECTIOUS 10.1016/s0923-2516(06)80049-x

Entry and release of hepatitis C virus in polarized human hepatocytes. 10.1128/jvi.00478-17

An ecological approach to discover new bioactive extracts and products: the case of extremophile plants. 10.1111/jphp.12728

Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus. 10.1128/jvi.00404-16

Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin. 10.1016/j.antiviral.2016.07.011

Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus 10.1101/325126

Viral hepatitis in the Peruvian Amazon: Ethnomedical context and phytomedical resource. 10.1016/j.jep.2020.112735

Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus. 10.1021/acsami.9b15032

Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication. 10.1128/jvi.02009-18

Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. 10.1371/journal.pone.0198226

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Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488

A yeast t-SNARE involved in endocytosis. 10.1091/mbc.9.10.2873

Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483

Julie Dam

Dam Julie

ORCID: 0000-0001-6871-2678

Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain 10.1016/j.cmet.2013.12.015

Anti-obesity phenotypic screening looking to increase OBR cell surface expression 10.1177/1087057113499185

New pharmacological perspectives for the leptin receptor in the treatment of obesity 10.3389/fendo.2014.00167

Endospanin 1 silencing in the hypothalamic arcuate nucleus contributes to sustained weight loss of high fat diet obese mice 10.1038/gt.2014.36

Hunting for the functions of short leptin receptor isoforms 10.1016/j.molmet.2013.09.001

Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression 10.1074/jbc.M113.462218

Design and validation of a homogeneous time-resolved fluorescence-based leptin receptor binding assay 10.1016/j.ab.2012.12.013

Homozygous deletion of an 80kb region comprising part of DNAJC6 and LEPR genes on chromosome 1P31.3 is associated with early onset obesity, mental retardation and epilepsy 10.1016/j.ymgme.2012.04.026

A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor 10.1016/j.cub.2011.11.043

Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway 10.1074/jbc.M111.224857

Improving leptin sensitivity in the search for a therapy for obesity | Améliorer la sensibilité à la leptine vers un remède contre l'obésité 10.1007/s11690-008-0151-3

Molecular architecture of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors 10.1074/jbc.M801526200

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity 10.1073/pnas.0706671104

Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers 10.1038/sj.embor.7400838

Variable Dimerization of the Ly49A Natural Killer Cell Receptor Results in Differential Engagement of its MHC Class I Ligand 10.1016/j.jmb.2006.07.005

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization 10.1038/sj.emboj.7601193

Techniques: New pharmacological perspectives for the leptin receptor 10.1016/j.tips.2006.02.009

Sedimentation velocity analysis of heterogeneous protein-protein interactions: Lamm equation modeling and sedimentation coefficient distributions c(s) 10.1529/biophysj.105.059568

Sedimentation velocity analysis of heterogeneous protein-protein interactions: Sedimentation coefficient distributions c(s) and asymptotic boundary profiles from Gilbert-Jenkins theory 10.1529/biophysj.105.059584

Calculating Sedimentation Coefficient Distributions by Direct Modeling of Sedimentation Velocity Concentration Profiles 10.1016/S0076-6879(04)84012-6

Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition 10.1016/j.ab.2003.12.014

Effect of multiple symmetries on the association of R67 DHFR subunits bearing interfacial complementing mutations 10.1110/ps.03309504

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb 10.1038/ni1006

A growing family of natural killers 10.1016/S0969-2126(03)00105-9

Complementation between dimeric mutants as a probe of dimer-dimer interactions in tetrameric dihydrofolate reductase encoded by R67 plasmid of E. coli 10.1006/jmbi.2000.4051

Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling. 10.1016/j.molmet.2016.10.009

Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice. 10.1155/2015/965056

Leptin receptors and mechanism of action 10.1007/978-3-319-09915-6

Améliorer la sensibilité à la leptine vers un remède contre l’obésité https://doi.org/10.1007/s11690-008-0151-3

Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity 10.1111/jpi.12462

The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development. DOI: 10.1038/s41467-018-03609-x

Hypothalamic endospanin 1 dissociates obesity from type 2 diabetes DOI: 10.1051/medsci/20183404003

Gain of affinity for VEGF165 binding within the VEGFR2/NRP1 cellular complex detected by an HTRF-based binding assay. DOI: 10.1016/j.bcp.2018.09.014

Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor. 10.1111/bph.14688

β-Arrestin-2 BRET Biosensors Detect Different β-Arrestin-2 Conformations in Interaction with GPCRs. 10.1021/acssensors.9b01414

GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors. 10.1007/s00018-019-03440-7

Amyloid beta peptide is an endogenous negative allosteric modulator of leptin receptor. 10.1159/000508105

SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET. 10.1016/j.chembiol.2021.06.008

Ralf Jockers

Jockers Ralf

ORCID: 0000-0002-4354-1750

http://www.institutcochin.fr/departments/emd/team-jockers

Melatonin receptors: molecular pharmacology and signalling in the context of system bias 10.1111/bph.13950

Herbicide biosensor based on photobleacing of the reaction centre of Rhodobacter sphaeroides 10.1016/0003-2670(93)80464-V

Understanding melatonin receptor pharmacology: Latest insights from mouse models, and their relevance to human disease 10.1002/bies.201400017

Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis 10.1210/me.2002-0222

Tandem affinity purification and identification of GPCR-associated protein complexes 10.1007/978-1-61779-126-0_23

Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers 10.1038/sj.embor.7400838

GPCR-Interacting Proteins, Major Players of GPCR Function 10.1016/B978-0-12-385952-5.00001-4

Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer's disease 10.1016/S0304-3940(01)01967-X

MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation 10.1111/j.1600-079X.2007.00525.x

Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function 10.1126/scisignal.2004302

Differential effects of melatonin and its downstream effector PKCα on subcellular localization of RGS proteins 10.1111/j.1600-079X.2005.00290.x

New pharmacological perspectives for the leptin receptor in the treatment of obesity 10.3389/fendo.2014.00167

Specific binding of photosynthetic reaction centres to herbicide-modified grating couplers 10.1016/0003-2670(93)80241-C

Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence 10.1111/j.1600-079X.2010.00750.x

The melatonergic agonist and clinically active antidepressant, agomelatine, is a neutral antagonist at 5-HT2C receptors 10.1017/S1461145710001045

Novel isoforms of Mel(1c) melatonin receptors modulating intracellular cyclic guanosine 3',5'- monophosphate levels 10.1210/me.11.8.1070

Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways 10.1111/j.1600-079X.2010.00784.x

Differential expression of high-affinity melatonin receptors (MT1) in normal and malignant human breast tissue 10.1309/1T4V-CT1G-UBJP-3EHP

On the presence of a putative fourth β-adrenoceptor in human adipose tissue. Pharmacological evidence for the existence of a fourth β- adrenoceptor in adipose tissue and in heart [1] (multiple letters) 10.1016/S0165-6147(98)01199-7

Oligomerization of human and viral 7TM proteins: A new viral strategy to manipulate host cells | Oligomérisation des protéines humaines et virales à sept domaines transmembranaires Nouvelle stratégie virale pour manipuler la cellule hôte 10.1051/medsci/20122810015

β2-Adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis 10.1074/jbc.274.41.28900

Update on melatonin receptors: IUPHAR Review 20 10.1111/bph.13536

Homozygous deletion of an 80 kb region comprising part of DNAJC6 and LEPR genes on chromosome 1P31.3 is associated with early onset obesity, mental retardation and epilepsy (vol 106, pg 345, 2012) 10.1016/j.ymgme.2015.03.004

Desensitization of the β-adrenergic response in human brown adipocytes 10.1210/en.139.6.2676

Influence of cell confluence on the cAMP signalling pathway in vascular smooth muscle cells 10.1016/j.cellsig.2017.03.025

Leptin receptors and mechanism of action 10.1007/978-3-319-09915-6_2

Stereospecific synthesis and bio-activity of novel β3-adrenoceptor agonists and inverse agonists 10.1016/j.bmc.2007.11.060

A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors 10.1074/mcp.M700435-MCP200

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells 10.1038/srep25765

N1-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors 10.1039/c4md00079j

Two transmembrane Cys residues are involved in 5-HT4 receptor dimerization 10.1016/j.bbrc.2007.03.030

Synthesis of Long-Chain Triazine Aldehydes - Substrates of BacterialM Luciferase and Photosynthetic Inhibitors 10.1515/znc-1992-7-814

Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease 10.1016/j.neurobiolaging.2006.06.002

Asymmetry of GPCR oligomers supports their functional relevance 10.1016/j.tips.2011.05.006

Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population 10.1371/journal.pone.0011495

A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor 10.1016/j.cub.2011.11.043

Improved donor/acceptor BRET couples for monitoring β-arrestin recruitment to G protein-coupled receptors 10.1002/biot.200900016

Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT 2 homodimers 10.1124/mol.104.000398

Peptide affinity purification for the isolation and identification of GPCR-associated protein complexes 10.1007/978-1-61779-126-0_22

Homozygous deletion of an 80kb region comprising part of DNAJC6 and LEPR genes on chromosome 1P31.3 is associated with early onset obesity, mental retardation and epilepsy 10.1016/j.ymgme.2012.04.026

BRET analysis of GPCR oligomerization: Newer does not mean better [1] 10.1038/nmeth0107-3

Cloning and functional analysis of a polymorphic variant of the ovine Mel 1a melatonin receptor 10.1016/S0167-4889(96)00179-6

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons 10.1111/jpi.12294

Multivalent-based drug design applied to serotonin 5-HT4 receptor oligomers 10.2174/138161209787315602

Modulation of melatonin receptors and G-protein function by microtubules 10.1111/j.1600-079X.2006.00371.x

Techniques: New pharmacological perspectives for the leptin receptor 10.1016/j.tips.2006.02.009

Past and Future Strategies for GPCR Deorphanization 10.1002/9780470627327.ch7

Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity 10.1182/blood-2011-08-372516

Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer 10.1074/jbc.M200729200

Heteromerization of human cytomegalovirus encoded chemokine receptors 10.1016/j.bcp.2011.06.009

Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain 10.1016/j.cmet.2013.12.015

Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression 10.1016/j.jad.2012.12.025

S32212, a novel serotonin type 2C receptor inverse agonist/α 2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization 10.1124/jpet.111.187468

Design and validation of a homogeneous time-resolved fluorescence-based leptin receptor binding assay 10.1016/j.ab.2012.12.013

Using quantitative BRET to assess G protein-coupled receptor homo- and heterodimerization 10.1007/978-1-61779-160-4_9

Gi and RGS proteins provide biochemical control of androgen receptor nuclear exclusion 10.1007/BF02686113

Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern 10.1016/j.eurpsy.2011.02.011

Anti-obesity phenotypic screening looking to increase OBR cell surface expression 10.1177/1087057113499185

Detection of herbicides via a bacterial photoreaction centre and bacterial luciferase 10.1016/0956-5663(93)85008-C

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization 10.1038/sj.emboj.7601193

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes 10.1038/ng.1053

Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients 10.1034/j.1600-079x.2002.00841.x

Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway 10.1096/fj.14-265678

G protein-coupled receptor oligomerization revisited: Functional and pharmacological perspectives 10.1124/pr.113.008052

Hunting for the functions of short leptin receptor isoforms 10.1016/j.molmet.2013.09.001

Techniques for the discovery of GPCR-associated protein complexes 10.1016/B978-0-12-391862-8.00018-1

Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: Implication for the understanding of metabolic syndrome 10.1096/fj.11-181792

Age-related decline in melatonin and Its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth 10.2174/1874609811306010016

Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease 10.1111/j.1600-079X.2004.00169.x

Frontiers Commentary on Tallet et al. Investigation of prolactin receptor activation and blockade using time-resolved fluorescence resonance energy transfer 10.3389/fendo.2014.00088

Suprachiasmatic nucleus neuropeptide expression in patients with Huntington's disease 10.5665/sleep.2314

Melatonin receptors, heterodimerization, signal transduction and binding sites: What's new? 10.1038/bjp.2008.184

Integrated optical immunosensor for s-triazine determination: Regeneration, calibration and limitations 10.1039/AN9941900437

G protein-coupled receptors in the spot light 10.1051/jbio/2013014

History and biological significance of GPCR heteromerization in the neuroendocrine system 10.1159/000330000

Bivalent ligands as specific pharmacological tools for G protein-coupled receptor dimers 10.2174/157016308786733591

Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains 10.1111/j.1365-2826.2012.02274.x

Melatonin MT-1-receptor immunoreactivity in the human eye 10.1136/bjo.86.9.1053

Molecular organization and dynamics of the melatonin MT 1 receptor/RGS20/G i protein complex reveal asymmetry of receptor dimers for RGS and G i coupling 10.1038/emboj.2010.236

Systematic protein–protein interaction mapping for clinically relevant human GPCRs 10.15252/msb.20167430

Design and validation of the first cell-impermeant melatonin receptor agonist 10.1111/bph.13856

The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm 10.1016/j.cmet.2016.08.015

Identification of Mel(1a) melatonin receptors in the human embryonic kidney cell line HEK293: Evidence of G protein-coupled melatonin receptors which do not mediate the inhibition of stimulated cyclic AMP levels 10.1016/S0014-5793(97)00315-3

Evidence for leptin receptor isoforms heteromerization at the cell surface 10.1016/j.febslet.2010.03.033

Cellular signaling by an agonist-activated receptor/G(s)α fusion protein 10.1073/pnas.91.19.8827

Are G protein-coupled receptor heterodimers of physiological relevance? - Focus on melatonin receptors 10.1080/07420520500521863

The BRET technology and its application to screening assays 10.1002/biot.200700222

Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: Association of melatonin mt2 receptor variants with type 2 diabetes 10.1210/me.2013-1101

MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential 10.1021/jm401343c

Biological significance of GPCR heteromerization in the neuro-endocrine system 10.3389/fendo.2011.00002

Detection of the human GPR50 orphan seven transmembrane protein by polyclonal antibodies mapping different epitopes 10.1111/j.1600-079X.2007.00437.x

Synthesis of specific bivalent probes that functionally interact with 5-HT4 receptor dimers 10.1021/jm070552t

Recent methodological advances in the discovery of GPCR-associated protein complexes 10.1016/j.tips.2008.10.009

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity 10.1073/pnas.0706671104

Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders 10.1111/j.1600-079X.2011.00902.x

Declining melatonin levels and MT1 receptor expression in aging rats is associated with enhanced mammary tumor growth and decreased sensitivity to melatonin 10.1007/s10549-010-0958-0

Differential signaling of human Mel1a and Mel1b melatonin receptors through the cyclic guanosine 3'-5'-monophosphate pathway 10.1016/S0006-2952(99)00134-3

The PDZ protein Mupp1 promotes Gi coupling and signaling of the Mt1 melatonin receptor 10.1074/jbc.M802069200

Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers 10.1074/jbc.M114.559542

Immunohistochemical localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampus 10.1097/01.pai.0000129054.16071.2f

Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway 10.1074/jbc.M111.224857

The 7-transmembrane protein homologue UL78 of the human cytomegalovirus forms oligomers and traffics between the plasma membrane and different intracellular compartments 10.1007/s00705-012-1246-6

The use of resonance energy transfer in high-throughput screening: BRET versus FRET 10.1016/S0165-6147(02)02062-X

Coupling of heterotrimeric Gi proteins to the erythropoietin receptor 10.1074/jbc.M003527200

Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand 10.1111/bph.12942

Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers 10.1074/jbc.M302002200

Expanding the concept of G protein-coupled receptor (GPCR) dimer asymmetry towards GPCR-interacting proteins 10.3390/ph4020273

Endospanin 1 silencing in the hypothalamic arcuate nucleus contributes to sustained weight loss of high fat diet obese mice 10.1038/gt.2014.36

Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling 10.1016/j.molmet.2016.10.009

Enhancement of immunoassay sensitivity by molecular modification of competitors 10.1016/0022-1759(93)90118-Q

Constitutive dimerization of human serotonin 5-HT4 receptors in living cells 10.1016/j.febslet.2005.04.040

The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease 10.2174/156720507779939823

Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes 10.1210/en.142.10.4264

Involvement of melatonin MT2 receptor mutants in type 2 diabetes development | Implication des mutations du récepteur de la mélatonine MT2 dans la survenue du diabète de type 2 10.1051/medsci/2013298018

Alternative drug discovery approaches for orphan GPCRs 10.1016/j.drudis.2007.09.011

Improving leptin sensitivity in the search for a therapy for obesity | Améliorer la sensibilité à la leptine vers un remède contre l'obésité 10.1007/s11690-008-0151-3

Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50 10.1111/bph.14029

Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure 10.1007/s00018-018-2876-y

Melatonin in type 2 diabetes mellitus and obesity 10.1038/s41574-018-0130-1

Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor 10.1038/s41598-018-26113-0

Gain of affinity for VEGF165 binding within the VEGFR2/NRP1 cellular complex detected by an HTRF-based binding assay 10.1016/j.bcp.2018.09.014

GPR50 in TGFbeta signaling and breast cancer 10.18632/oncoscience.433

Hypothalamic endospanin 1 dissociates obesity from type 2 diabetes 10.1051/medsci/20183404003

Melatonin Receptor Signaling: Impact of Receptor Oligomerization on Receptor Function 10.1016/bs.ircmb.2018.02.002

Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity 10.1111/jpi.12462

The orphan GPR50 receptor promotes constitutive TGF beta receptor signaling and protects against cancer development 10.1038/s41467-018-03609-x

Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling 10.1126/scisignal.aan6622

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release 10.1073/pnas.1705768114

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions 10.1038/s41598-017-08996-7

Comment on "The use of BRET to study receptor-protein interactions" 10.3389/fendo.2014.00003

Exon Sequencing of G Protein-Coupled Receptor Genes and Perspectives for Disease Treatment 10.1007/978-1-62703-779-2_17

Leptin induces breast cancer metastasis through a Neuropilin-1 (NRP-1)/OBR complex 10.1158/1538-7445.am2014-3293

Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor 10.1111/bph.14688

Melatonin receptor structures shed new light on melatonin research 10.1111/jpi.12606

Melatonin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database 10.2218/gtopdb/F39/2019.4

β-Arrestin-2 BRET Biosensors Detect Different β-Arrestin-2 Conformations in Interaction with GPCRs 10.1021/acssensors.9b01414

Melatonin MT 1 and MT 2 receptor ERK signaling is differentially dependent on G i/o and G q/11 proteins 10.1111/jpi.12641

Melatonin promotes regeneration of injured motor axons via MT 1 receptors 10.1111/jpi.12695

Melatonin controversies, an update 10.1111/jpi.12702

Pharmacological evidence for transactivation within melatonin MT 2 and serotonin 5‐HT 2C receptor heteromers in mouse brain 10.1096/fj.202000305R

Journal of pineal research guideline for authors: Defining and characterizing melatonin targets 10.1111/jpi.12712

Philippe Froguel

Froguel Philippe

ORCID: 0000-0003-2972-0784

Transmission of Type 2 diabetes to sons and daughters: the D.E.S.I.R. cohort. 10.1111/dme.13446

Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis 10.1183/13993003.02314-2016

Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles 10.1371/journal.pone.0179583

Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis 10.1371/journal.pone.0176396

Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults 10.1371/journal.pgen.1006528

Early metabolic markers identify potential targets for the prevention of type 2 diabetes 10.1007/s00125-017-4325-0

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. 10.2337/db16-1253

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion. 10.1016/j.molmet.2017.03.011

8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3-5 October 2016. 10.1515/dmpt-2017-0011

Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children 10.1155/2017/2432957

Erratum: Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population. 10.1002/oby.21803

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 10.1038/ncomms14977

The case for too little melatonin signalling in increased diabetes risk. 10.1007/s00125-017-4255-x

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 10.2337/db16-1329

Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach. 10.1186/s12916-017-0784-x

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. 10.1016/j.ajhg.2017.01.011

Hepatic DPP4 DNA Methylation Associates With Fatty Liver 10.2337/db15-1716

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KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. 10.1073/pnas.1611243113

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Detection of human adaptation during the past 2000 years. 10.1126/science.aag0776

Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. 10.1016/j.molmet.2016.08.011

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The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm. 10.1016/j.cmet.2016.08.015

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Genomic insights into the origin of farming in the ancient Near East. 10.1038/nature19310

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DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes. 10.2337/db16-0014

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Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis 10.1371/journal.pone.0158051

Eating Behavior, Low-Frequency Functional Mutations in the Melanocortin-4 Receptor (MC4R) Gene, and Outcomes of Bariatric Operations: A 6-Year Prospective Study 10.2337/dc16-0115

Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study. 10.1016/j.numecd.2016.04.010

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. 10.1038/mp.2016.71

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response 10.1016/j.celrep.2016.03.079

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. 10.1093/hmg/ddw048

Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity. 10.4137/IJTR.S11717

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk 10.1038/ncomms10495

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function 10.1038/ncomms10023

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index 10.1093/hmg/ddv472

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci 10.1038/ng.3437

What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity? 10.1371/journal.pone.0143373

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 10.1371/journal.pgen.1005378

Genetic association analyses highlight biological pathways underlying mitral valve prolapse 10.1038/ng.3383

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation 10.1002/oby.21199

Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population 10.1002/oby.21142

Directional dominance on stature and cognition in diverse human populations 10.1038/nature14618

A girl with incomplete Prader-Willi syndrome and negative MS-PCR, found to have mosaic maternal UPD-15 at SNP array 10.1002/ajmg.a.37222

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study 10.1016/S2213-8587(15)00127-8

The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis 10.1007/s00125-015-3659-8

Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels 10.1136/jmedgenet-2015-103065

Association of gene variants with susceptibility to type 2 diabetes among Omanis 10.4239/wjd.v6.i2.358

Genetic studies of body mass index yield new insights for obesity biology 10.1038/nature14177

New genetic loci link adipose and insulin biology to body fat distribution 10.1038/nature14132

Rare and Common Genetic Events in Type 2 Diabetes: What Should Biologists Know? 10.1016/j.cmet.2014.12.020

Genetic Determinants of Leucocyte Telomere Length in Children: a Neglected and Challenging Field 10.1111/ppe.12173

Biological interpretation of genome-wide association studies using predicted gene functions 10.1038/ncomms6890

RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human beta Cells 10.1016/j.celrep.2014.11.010

Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children 10.1007/s00125-014-3441-3

Defining the role of common variation in the genomic and biological architecture of adult human height 10.1038/ng.3097

Identification of Two Novel Loss-of-Function SIM1 Mutations in Two Overweight Children with Developmental Delay 10.1002/oby.20886

Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients 10.1016/j.soard.2013.12.016

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes 10.1371/journal.pgen.1004517

Fine-scale human genetic structure in Western France 10.1038/ejhg.2014.175

Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index 10.1371/journal.pgen.1004508

Placental antiangiogenic prolactin fragments are increased in human and rat maternal diabetes 10.1016/j.bbadis.2014.06.026

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study 10.1007/s00125-014-3277-x

A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity 10.1038/ijo.2014.96

Common Genetic Variants and Risk of Brain Injury After Preterm Birth 10.1542/peds.2013-3011

Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study 10.1371/journal.pmed.1001647

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2 10.1042/BJ20131618

Role of the Unfolded Protein Response in beta Cell Compensation and Failure during Diabetes 10.1155/2014/795171

Quality control and conduct of genome-wide association meta-analyses 10.1038/nprot.2014.071

Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice 10.1371/journal.pone.0092684

Multi-ethnic fine-mapping of 14 central adiposity loci 10.1093/hmg/ddu183

A Central Role for GRB10 in Regulation of Islet Function in Man 10.1371/journal.pgen.1004235

Low copy number of the salivary amylase gene predisposes to obesity 10.1038/ng.2939

Comment On: Valette et al. Melanocortin-4 Receptor Mutations and Polymorphisms Do Not Affect Weight Loss after Bariatric Surgery. PLOS ONE 2012; 7(11):E48221 10.1371/journal.pone.0093324

CDKN2B expression and subcutaneous adipose tissue expandability: Possible influence of the 9p21 atherosclerosis locus 10.1016/j.bbrc.2014.03.075

Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions 10.1155/2014/873679

Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study 10.1016/S2213-8587(13)70059-7

Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes 10.1007/s12015-014-9503-6

Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4 alpha at the protein level 10.1007/s00125-013-3154-z

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility 10.1038/ng.2897

Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. 10.1155/2013/139239

Direct Estimates of Natural Selection in Iberia Indicate Calcium Absorption Was Not the Only Driver of Lactase Persistence in Europe 10.1093/molbev/msu049

Novel LEPR Mutations in Obese Pakistani Children Identified by PCR-Based Enrichment and Next Generation Sequencing 10.1002/oby.20667

Leveraging Cross- Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms 10.1016/j.cell.2013.10.058

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity 10.2337/db13-0949

Coffee and tea consumption, genotype- based CYP1A2 and NAT2 activity and colorectal cancer risk- Results from the EPIC cohort study 10.1002/ijc.28655

Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates 10.1371/journal.pgen.1003919

Peroxisome Proliferator-activated Receptor gamma Regulates Genes Involved in Insulin/Insulin-like Growth Factor Signaling and Lipid Metabolism during Adipogenesis through Functionally Distinct Enhancer Classes 10.1074/jbc.M113.526996

The SH2B1 obesity locus and abnormal glucose homeostasis: Lack of evidence for association from a meta-analysis in individuals of European ancestry 10.1016/j.numecd.2013.05.001

Highly Sensitive Diagnosis of 43 Monogenic Forms of Diabetes or Obesity Through One-Step PCR-Based Enrichment in Combination With Next-Generation Sequencing 10.2337/dc13-0698

Meal Frequencies Modify the Effect of Common Genetic Variants on Body Mass Index in Adolescents of the Northern Finland Birth Cohort 1986 10.1371/journal.pone.0073802

GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm 10.1371/journal.pgen.1003657

Genome-wide association study identifies three novel loci for type 2 diabetes 10.1093/hmg/ddt399

Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts 10.1007/s00125-013-3021-y

Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck 10.1186/gb-2013-14-7-309

Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics 10.1016/j.ajhg.2013.06.011

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death 10.1038/ng.2712

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications 10.1038/ng.2700

Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes 10.1186/1742-4682-10-45

Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore? 10.1371/journal.pone.0067650

Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features 10.1172/JCI68035

Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects 10.1007/s12020-013-0009-9

Evidence for tuning adipocytes ICER levels for obesity care. 10.4161/adip.20000

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits 10.1371/journal.pgen.1003500

Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations 10.1007/s00109-013-1027-z

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders 10.1038/ng.2610

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture 10.1038/ng.2606

Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci 10.1101/gr.155127.113

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family 10.1016/j.diabet.2013.02.007

Rare Genomic Structural Variants in Complex Disease: Lessons from the Replication of Associations with Obesity 10.1371/journal.pone.0058048

From obesity genetics to the future of personalized obesity therapy 10.1038/nrendo.2013.57

The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity,Weight loss and resting metabolic rate 10.1016/j.bbrc.2013.03.031

Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity 10.1002/oby.20443

Integration of clinical data with a genome-scale metabolic model of the human adipocyte 10.1038/msb.2013.5

What Is the Contribution of Two Genetic Variants Regulating VEGF Levels to Type 2 Diabetes Risk and to Microvascular Complications? 10.1371/journal.pone.0055921

Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels 10.1007/s00125-013-2875-3

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts 10.1371/journal.pmed.1001383

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children 10.1186/1471-2350-14-21

Blood Microbiota Dysbiosis Is Associated with the Onset of Cardiovascular Events in a Large General Population: The DESIR Study 10.1371/journal.pone.0054461

Improved Protocol For Laser Microdissection Of Human Pancreatic Islets From Surgical Specimens 10.3791/50231

Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India 10.2337/db12-1077

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 10.1038/ng.2500

Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men 10.1210/jc.2012-2764

Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes 10.1007/s00125-012-2794-8

Seventy-five genetic loci influencing the human red blood cell 10.1038/nature11677

Estimation of Newborn Risk for Child or Adolescent Obesity: Lessons from Longitudinal Birth Cohorts 10.1371/journal.pone.0049919

Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21 10.2337/db12-0406/-/DC1

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism 10.1038/ng.2477

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes 10.1007/s00125-012-2756-1

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population 10.1038/ijo.2012.175

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site 10.1182/blood-2012-01-401893

Response to comment on: Marquez et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes 2012;61:524-530. 10.2337/db12-0800

A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans 10.2337/db12-0454

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways 10.1038/ng.2385

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals 10.1007/s00125-012-2660-8

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes 10.1038/ng.2383

GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes 10.1007/s00125-012-2645-7

Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms 10.1371/journal.pone.0040351

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers 10.1093/nar/gks595

Whole-Exome Sequencing and High Throughput Genotyping Identified KCNJ11 as the Thirteenth MODY Gene 10.1371/journal.pone.0037423

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits 10.2337/db11-1515

Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases 10.1371/journal.pgen.1002741

The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size 10.1371/journal.pone.0038216

Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity 10.1371/journal.pone.0035810

Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity 10.1093/hmg/dds187

Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone 10.1152/ajpregu.00373.2011

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance 10.1038/ng.2274

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women 10.1371/journal.pgen.1002695

The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis 10.1016/j.beem.2011.12.001

Circadian Gene Variants and Susceptibility to Type 2 Diabetes: A Pilot Study 10.1371/journal.pone.0032670

A genome-wide association meta-analysis identifies new childhood obesity loci 10.1038/ng.2247

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals 10.1371/journal.pgen.1002607

High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families 10.1016/j.ymgme.2012.03.001

European genetic variants associated with type 2 diabetes in North African Arabs 10.1016/j.diabet.2012.02.003

Loss-of-Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population 10.1038/oby.2012.77

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations 10.1093/hmg/dds113

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels 10.2337/db11-0973

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis 10.1038/ng.2232

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron 10.1038/ng.2218

A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels 10.1371/journal.pone.0032327

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations 10.1371/journal.pgen.1002490

Multicohort Genomewide Association Study Reveals a New Signal of Protection Against HIV-1 Acquisition 10.1093/infdis/jis028

Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study 10.1111/j.1365-2796.2012.02532.x

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma 10.1038/ng.1085

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human 10.1038/nature10798

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes 10.1038/ng.1053

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans 10.1371/journal.pone.0029202

Parent-Offspring Correlations in Pedometer-Assessed Physical Activity 10.1371/journal.pone.0029195

Clinical and Metabolic Features of Adult-Onset Diabetes Caused by ABCC8 Mutations 10.2337/dc11-1469

Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk 10.2337/db11-0728

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity 10.2337/db11-0305

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians 10.1038/ng.1019

New gene functions in megakaryopoiesis and platelet formation 10.1038/nature10659

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children 10.1371/journal.pmed.1001116

Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion 10.1074/jbc.M111.254995

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma 10.1038/ng.970

Low Water Intake and Risk for New-Onset Hyperglycemia 10.2337/dc11-0652

Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene 10.1371/journal.pone.0025470

The Lin28/let-7 Axis Regulates Glucose Metabolism 10.1016/j.cell.2011.08.033

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus 10.1038/nature10406

Effects of Genetic Susceptibility for Type 2 Diabetes on the Evolution of Glucose Homeostasis Traits Before and After Diabetes Diagnosis Data From the DESIR Study 10.2337/db10-1442

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes 10.2337/db11-0415

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci 10.1038/ng.921

ITIH-5 Expression in Human Adipose Tissue Is Increased in Obesity 10.1038/oby.2011.268

Characterization of the human SLC30A8 promoter and intronic enhancer 10.1530/JME-11-0055

A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes 10.1007/s00125-011-2261-y

Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes 10.1186/1471-2350-12-99

Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity 10.1038/oby.2011.200

Systems medicine and integrated care to combat chronic noncommunicable diseases 10.1186/gm259

Common Variants in FTO, MC4R, TMEM18, PRL, AIF1 and PCSK1 Show Evidence of Association With Adult Obesity in the Greek Population 10.1038/oby.2011.177

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study 10.1007/s00125-011-2182-9

Number of children and change in markers of metabolic health over 9-years in men and women. Data from the DESIR study 10.1016/j.diabet.2011.04.006

Accurate Single-Nucleotide Polymorphism Allele Assignment in Trisomic or Duplicated Regions by Using a Single Base-Extension Assay with MALDI-TOF Mass Spectrometry 10.1373/clinchem.2010.159558

Disruption of a Novel Kruppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus 10.1074/jbc.M110.215822

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes 10.1038/ng.833

famCNV: copy number variant association for quantitative traits in families 10.1093/bioinformatics/btr264

Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations 10.1038/ijo.2011.86

Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study 10.1038/ijo.2011.91

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children 10.2337/db10-1575

Chromosome 19p13.3 Deletion in a Patient With Macrocephaly, Obesity, Mental Retardation, and Behavior Problems 10.1002/ajmg.a.33986

Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway 10.1074/jbc.M111.224857

Dairy Consumption and the Incidence of Hyperglycemia and the Metabolic Syndrome Results from a French prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) 10.2337/dc10-1772

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits 10.1371/journal.pgen.1001324

Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue 10.1038/ijo.2011.22

Metabolic health, obesity and 9-year incidence of peripheral arterial disease: The DESIR study 10.1016/j.atherosclerosis.2011.02.032

Investigation of the HIN200 Locus in UK SLE Families Identifies Novel Copy Number Variants 10.1111/j.1469-1809.2011.00641.x

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease 10.1038/ng.782

Bio-Repository of DNA in stroke (BRAINS): A study protocol 10.1186/1471-2350-12-34

Childhood Obesity Is Associated with Shorter Leukocyte Telomere Length 10.1210/jc.2010-2924

TCF7L2 splice variants have distinct effects on beta-cell turnover and function 10.1093/hmg/ddr072

Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals 10.3945/ajcn.110.000828

Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations 10.1111/j.1399-5448.2010.00719.x

Influence of blood glucose on heart rate and cardiac autonomic function. The DESIR study 10.1111/j.1464-5491.2010.03222.x

Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine 10.1111/j.1749-6632.2010.05880.x

Screening Low-Frequency SNPS From Genome-Wide Association Study Reveals a New Risk Allele for Progression to AIDS 10.1097/QAI.0b013e318204982b

Molecular Diagnosis of Neonatal Diabetes Mellitus Using Next-Generation Sequencing of the Whole Exome 10.1371/journal.pone.0013630

Lack of Association of CD36 SNPs With Early Onset Obesity: A Meta-Analysis in 9,973 European Subjects 10.1038/oby.2010.226

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 10.1038/ng.686

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution 10.1038/ng.685

Mean and yearly changes in blood pressure with age in the metabolic syndrome: the DESIR study 10.1038/hr.2010.180

Common Variants at 10 Genomic Loci Influence Hemoglobin A(1C) Levels via Glycemic and Nonglycemic Pathways 10.2337/db10-0502

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B 10.1038/ng.660

Evaluation of A2BP1 as an Obesity Gene 10.2337/db09-1604

The emerging genetics of type 2 diabetes 10.1016/j.molmed.2010.06.004

Multiple-Cohort Genetic Association Study Reveals CXCR6 as a New Chemokine Receptor Involved in Long-Term Nonprogression to AIDS 10.1086/655782

Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies 10.2337/dc10.1150

Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the G6PC2 Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels 10.2337/db10-0389

Expression of the selenoprotein S (SELS) gene m subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors 10.1016/j.metabol.2010.05.011

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis 10.1038/ng.609

Monogenic forms of diabetes mellitus: an update. 10.1016/S1575-0922(09)73513-2

cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs 10.1038/NMETH.1466

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups 10.1371/journal.pgen.1000916

Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study 10.1097/HJH.0b013e328338a901

Inferring combined CNV/SNP haplotypes from genotype data 10.1093/bioinformatics/btq157

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High Baseline Insulin Levels Associated With 6-Year Incident Observed Sleep Apnea 10.2337/dc09-1901

Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population 10.1038/jhg.2010.10

Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets 10.1016/j.ymgme.2010.01.001

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Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population 10.1159/000178157

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Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia 10.1038/ng.443

Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians 10.2337/db08-1805

Genetic Variant m HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control-Related Traits 10.2337/009-0652

Tenomodulin Is Highly Expressed in Adipose Tissue, Increased in Obesity, and Down-Regulated during Diet-Induced Weight Loss 10.1210/jc.2009-0292

Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations 10.1016/j.ajhg.2009.06.002

Improved donor/acceptor BRET couples for monitoring beta-arrestin recruitment to G protein-coupled receptors. 10.1002/biot.200900016

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants 10.2337/db09-0551

The genetic contribution to non-syndromic human obesity 10.1038/nrg2594

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism 10.1093/hmg/ddp263

The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes 10.1530/EJE-09-0122

Sex hormone-binding globulin predicts the incidence of hyperglycemia in women: interactions with adiponectin levels 10.1530/EJE-09-0202

Center Effect on Ankle-Brachial Index Measurement when Using the Reference Method (Doppler and Manometer): Results From a Large Cohort Study 10.1038/ajh.2009.78

Common Variation in SIM1 Is Reproducibly Associated With BMI in Pima Indians 10.2337/db09-0028

Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study 10.1038/ijo.2009.59

Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q 10.2337/db09-0081

The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects 10.1093/hmg/ddp169

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Regulation of carboxylesterase 1 (CES1) in human adipose tissue 10.1016/j.bbrc.2009.03.120

G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release Studies Involving 19,605 Europeans 10.2337/db08-1660

A Rare Variant in the Visfatin Gene (NAMPT/PBEF1) Is Associated With Protection From Obesity 10.1038/oby.2009.75

Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles - a cohort study 10.1186/1471-2350-10-27

Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease 10.1159/000184688

TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia 10.1016/j.patbio.2009.01.003

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease 10.1016/j.bbrc.2009.03.014

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations 10.1007/s00109-009-0451-6

Mutations in G6PC2 do not contribute to monogenic forms of early infancy diabetes and beta cell dysfunction 10.1007/s00125-009-1299-6

Evaluating the association of common APOA2 variants with type 2 diabetes 10.1186/1471-2350-10-13

Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans 10.1007/s00439-009-0626-9

Common genetic variation near MC4R is associated with eating behaviour patterns in European populations 10.1038/ijo.2008.279

Association Studies on Ghrelin and Ghrelin Receptor Gene Polymorphisms With Obesity 10.1038/oby.2008.589

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations 10.1038/ng.301

Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height 10.1530/EJE-08-0794

Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02) 10.1086/596067

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk 10.1038/ng.277

Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population 10.1016/j.diabet.2008.06.005

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The Q121 Variant of ENPP1 May Protect From Childhood Overweight/obesity in the Italian Population 10.1038/oby.2008.470

Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose 10.1097/FPC.0b013e32831101ef

A Genetic Study of the Ghrelin and Growth Hormone Secretagogue Receptor (GHSR) Genes and Stature 10.1111/j.1469-1809.2008.00484.x

Small Deletion Variants Have Stable Breakpoints Commonly Associated with Alu Elements 10.1371/journal.pone.0003104

The FTO gene is associated with adulthood obesity in the Mexican population 10.1038/oby.2008.367

Predicting Diabetes: Clinical, Biological, and Genetic Approaches Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) 10.2337/dc08-0368

Effect of ENPP1/PC-1-K121Q and PPAR gamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population 10.1016/j.diabres.2008.06.004

Common nonsynonymous variants in PCSK1 confer risk of obesity 10.1038/ng.177

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees 10.2337/db08-0153

The common P446L polymorphism in GCAR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population 10.2337/db07-1807

Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: Potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant-1659G \textgreater C 10.1210/jc.2007-2504

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies 10.1186/1471-2350-9-45

Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value 10.1371/journal.pone.0002031

Common variants near MC4R are associated with fat mass, weight and risk of obesity 10.1038/ng.140

Common genetic variation near MC4R is associated with waist circumference and insulin resistance 10.1038/ng.156

Inflammation is associated with a decrease of lipogenic factors in omental fat in women 10.1152/ajpregu.00926.2007

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels 10.1126/science.1156849

Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes 10.1210/er.2007-0024

Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2) 10.2337/dc07-2017

Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians 10.2337/db07-1789

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans 10.1038/ejhg.2008.64

INS VNTR is not associated with childhood obesity in 1,023 families: A family-based study 10.1038/oby.2008.209

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations 10.1093/hmg/ddn089

Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids 10.1007/s00125-008-0973-4

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults 10.2337/db07-1547

R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population 10.1093/hmg/ddn070

Genome-wide association scans identified CTNNBL1 as a novel gene for obesity 10.1093/hmg/ddn072

Evaluating the association of common PBX1 variants with type 2 diabetes 10.1186/1471-2350-9-14

Neonatal hyperglycaemia and abnormal development of the pancreas 10.1016/j.beem.2007.08.003

Effects of TCF7L2 polymorphisms on obesity in European populations 10.1038/oby.2007.77

Meta-analysis of 23 type 2 diabetes linkage studies from the international type 2 diabetes linkage analysis consortium 10.1159/000114164

Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: A report from the French ND (Neonatal Diabetes) Study Group 10.2337/db07-1358

Analysis of novel risk loci for type 2 diabetes in a general French population: the DESIR study 10.1007/s00109-007-0295-x

The EBPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: Evidence from an updated meta-analysis in 42,042 subjects 10.2337/db07-1336

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations 10.1007/s00125-007-0887-6

Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids 10.1007/s00125-007-0857-z

Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children 10.2337/db07-1273

Lack of association between the Pro(12)Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population 10.1007/s00592-007-0013-8

A single-nucleotide polymorphism in the p110 beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents 10.1210/jc.2007-1822

Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study (vol 272, pg 358, 2012) 10.1111/joim.12059

High prevalence of leptin and melanocotin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families (vol 106, pg 121, 2012) 10.1016/j.ymgme.2013.05.015

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron (vol 44, pg 458, 2012) 10.1038/ng0512-609

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (vol 42, pg 579, 2010) 10.1038/ng0411-388b

Response to the letter to the editor: "HIF-1 alpha protein rather than mRNA as a marker of hypoxia in adipose tissue in obesity," by Trayhurn et al. 10.1152/ajpregu.90722.2008

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (vol 42, pg 105, 2010) 10.1038/ng0510-464a

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia (vol 41, pg 1110, 2009) 10.1038/ng1009-1156c

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity 10.1073/pnas.0706671104

Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population 10.1007/s00125-007-0827-5

Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online. 10.1002/humu.9511

Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes 10.1016/j.diabet.2007.06.002

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Neonatal diabetes: a disease linked to multiple mechanisms 10.1016/j.arcped.2007.08.010

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study 10.1007/s00125-007-0787-9

Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity 10.1210/jc.2006-2316

Analysis of KLF transcription factor family gene variants in type 2 diabetes 10.1186/1471-2350-8-53

Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases 10.1093/hmg/ddm208

Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium 10.1086/520599

Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity 10.1186/1471-2350-8-44

TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population 10.1186/1471-2350-8-37

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity 10.1038/ng2046

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene 10.1093/hmg/ddm132

Variation in FTO contributes to childhood obesity and severe adult obesity 10.1038/ng2048

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis 10.1007/s00109-007-0203-4

Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes 10.1210/jc.2006-2657

New ABCC8 mutations in relapsing neonatal diabetes and clinical features 10.2337/db-1540

Coexistence in the same family of both focal and diffuse forms of hyperinsulinism 10.2337/dc06-2327

Preadipocyte response and impairment of differentiation in an inflammatory environment 10.1016/j.bbrc.2007.03.053

Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits 10.2337/db06-1305

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects 10.2337/db06-0930

A genome-wide association study identifies novel risk loci for type 2 diabetes 10.1038/nature05616

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions 10.1038/nm1557

Two Caucasian families with the hepatocyte nuclear factor-1 alpha mutation Tyr218Cys 10.1055/s-2007-955099

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population 10.1007/s00125-006-0588-6

Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women 10.1356/JBMR.070114

Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects 10.1007/s00125-006-0555-2

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No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases 10.1038/sj.ejhg.5201754

Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies. 10.1017/S1462399406000147

No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects 10.1007/s00125-006-0505-z

Genotype-by-nutrient interactions assessed in European obese women - A case-only study 10.1007/s00394-006-0619-6

TCF7L2 variation predicts hyperglycentia incidence in a French general population - The Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study 10.2337/db06-0692

Epistasis between type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans 10.1111/j.1469-1809.2006.00289.x

Impact of a CART promoter genetic variation on plasma lipid profile in a general population 10.1016/j.ymgme.2006.08.012

Transcription factor TCF7L2 genetic study in the French population - Expression in human beta-cells and adipose tissue and strong association with type 2 diabetes 10.2337/db06-0474

Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians 10.2337/db06-0337

Genetics of obesity and the prediction of risk for health 10.1093/hmg/ddl215

Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q 10.2337/db06-0088

Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes 10.2337/db05-1369

Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women 10.1016/j.bbrc.2006.07.068

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Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses 10.1016/j.ymgme.2006.05.013

Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population 10.1186/1471-2350-7-44

Hepatocyte nuclear factor-4 alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population 10.2337/db05-0620

Genetic basis of maturity-onset diabetes of the young 10.1016/j.ecl.2006.02.009

The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults 10.1210/jc.2005-2245

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance 10.1016/j.cmet.2006.01.006

Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women 10.1007/s00198-005-2022-1

Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1 10.1007/s00439-005-0036-6

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes 10.1038/ng1604

GAD2: A polygenic contribution to genetic susceptibility for common obesity? 10.1016/j.patbio.2004.09.008

Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes 10.1007/s00125-005-1806-3

Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity 10.1007/s00125-005-1729-z

Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population 10.1186/1471-2156-6-19

Implication of the Pro 12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population 10.1186/1471-2350-6-11

Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function 10.1073/pnas.0409177102

The genetics of human obesity 10.1038/nrg1556

Effect of common polymorphisms in the HNF4 alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population 10.1007/s00125-004-1665-3

Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children? 10.1210/jc.2004-1468

The EIF2AK3 gene region and type 1 diabetes in subjects from South India 10.1038/sj.gene.6364139

Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects 10.1007/s00125-004-1432-5

A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. 10.1002/humu.9256

Understanding the rising incidence of type 2 diabetes in adolescence 10.1136/adc.2003.028548

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity 10.1074/jbc.M402367200

A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population 10.1016/j.atherosclerosis.2003.12.029

GAD2 on chromosome 10p12 is a candidate gene for human obesity 10.1371/journal.pbio.0000068

Dissection of an inverted X(p21.3q27.1) chromosome associated with mental retardation 10.1159/000074167

Impaired multimerization of human adiponectin mutants associated with diabetes - Molecular structure and multimer formation of adiponectin 10.1074/jbc.M300365200

A meta-analysis of four European genome screens (GIFT consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes 10.1093/hmg/ddg195

PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population 10.1007/s00125-003-1170-0

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects 10.1038/nature01705

Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease 10.1038/sj.mp.4001344

Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians 10.1007/s00125-003-1083-y

Does the-11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families? 10.1007/s00125-003-1050-7

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations 10.1093/hmg/ddg016

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis 10.1074/jbc.M209033200

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase 10.1038/nm788

Rare variants identified in the HNF-4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes 10.1007/s00125-002-0913-7

Genetic approaches to the molecular understanding of type 2 diabetes 10.1152/ajpendo.00099.2002

Disruption of adiponectin causes insulin resistance and neointimal formation. 10.1074/jbc.C200251200

Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children 10.1067/mpd.2001.116284

Nd2Ba2CaZn2Ti3O14.4: A new high dielectric constant oxide having a disordered (cubic) perovskite structure 10.1021/cm030043p

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A Novel Rare Missense Variation of the Gene: Evidencesof Implication in Crohn's Disease. 10.3390/ijms20040835

A novel NEUROG3 mutation in neonatal diabetes associated with a neuro-intestinal syndrome 10.1111/pedi.12576

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers 10.1002/lipd.12087

Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults 10.1016/j.ebiom.2018.10.066

Cdkn2a deficiency promotes adipose tissue browning 10.1016/j.molmet.2017.11.012

CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability 10.1016/j.molmet.2018.05.005

Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS 10.1371/journal.pone.0204861

Epigenome-wide association study of adiposity and future risk of obesity-related diseases 10.1038/s41366-018-0064-7

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes 10.2337/dc18-1032

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation 10.1016/j.scr.2018.02.017

Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes 10.1002/oby.22064

High Prevalence of Rare Monogenic Forms of Obesity in Obese Guadeloupean Afro-Caribbean Children 10.1210/jc.2017-01956

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes 10.2337/db17-1539

Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose 10.3389/fgene.2018.00210

Loss-of-function mutations in ADCY3 cause monogenic severe obesity 10.1038/s41588-017-0023-6

MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue 10.1016/j.jacl.2018.07.009

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes 10.1007/s00125-017-4500-3

The unique clinical spectrum of maturity onset diabetes of the young type 3 10.1016/j.diabres.2017.10.024

Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling 10.1126/scisignal.aan6622

Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease 10.3389/fendo.2017.00304

Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? 10.1007/s11892-017-0957-1

Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect 10.1186/s13148-020-00858-w

Clustering for a better prediction of type 2 diabetes mellitus 10.1038/s41574-021-00475-4