Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function
Ying Lin Jacob M. Wozniak Neil J. Grimsey Sravan Girada Anand Patwardhan Olivia Molinar-Inglis Thomas H. Smith John D. Lapek David J. Gonzalez JoAnn Trejo
JOANN TREJO
TREJO JOANN / Trejo J A
ORCID: 0000-0003-4405-6228
GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling 10.3390/ijms19071886
Endo-lysosomal sorting of G-protein-coupled receptors by ubiquitin: Diverse pathways for G-protein-coupled receptor destruction and beyond. 10.1111/tra.12619
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. 10.1016/j.celrep.2018.08.061
Faculty Equity, Diversity, Culture and Climate Change in Academic Medicine: A Longitudinal Study 10.1016/j.jnma.2018.05.004
G protein–coupled receptors activate p38 MAPK via a non-canonical TAB1–TAB2– and TAB1–TAB3–dependent pathway in endothelial cells 10.1074/jbc.ra119.007495
A modular laboratory course using planarians to study genes involved in tissue regeneration 10.1002/bmb.21259
The unfolded protein response regulator ATF6 promotes mesodermal differentiation 10.1126/scisignal.aan5785
The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein–coupled receptor lysosomal sorting and signaling 10.1074/jbc.ra117.001516
A reflection on faculty diversity in the 21st century 10.1091/mbc.e17-08-0505
Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin 10.1074/jbc.m117.782359
Challenges and Opportunities in Protease-Activated Receptor Drug Development 10.1146/annurev-pharmtox-011613-140016
Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins 10.1074/jbc.m116.729285
ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif 10.1371/journal.pone.0157587
Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin 10.1097/moh.0000000000000232
Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins 10.1074/jbc.m115.702993
The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein–coupled receptor lysosomal sorting 10.1091/mbc.e15-05-0284
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes 10.1083/jcb.201504007
GPCR sorting at multivesicular endosomes 10.1016/bs.mcb.2015.05.006
N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias 10.1073/pnas.1508838112
Group B Streptococcal Infection and Activation of Human Astrocytes 10.1371/journal.pone.0128431
Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development 10.1016/j.ydbio.2015.05.011
Characterization of Thrombin-Bound Dabigatran Effects on Protease-Activated Receptor-1 Expression and Signaling In Vitro 10.1124/mol.114.096446
Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination 10.1016/j.ceb.2013.11.004
A General Method for Site Specific Fluorescent Labeling of Recombinant Chemokines 10.1371/journal.pone.0081454
Endosomal Signaling by Protease-Activated Receptors 10.1016/b978-0-12-397925-4.00022-5
Regulation of Protease-activated Receptor 1 Signaling by the Adaptor Protein Complex 2 and R4 Subfamily of Regulator of G Protein Signaling Proteins 10.1074/jbc.m113.528273
Cofactoring and Dimerization of Proteinase-Activated Receptors 10.1124/pr.111.004747
The Chemokine Receptor CCR1 Is Constitutively Active, Which Leads to G Protein-independent, β-Arrestin-mediated Internalization 10.1074/jbc.m113.503797
Palmitoylation of Protease-activated Receptor-1 Regulates Adaptor Protein Complex-2 and -3 Interaction with Tyrosine-based Motifs and Endocytic Sorting 10.1074/jbc.m113.469866
Transactivation of the PAR1-PAR2 Heterodimer by Thrombin Elicits β-Arrestin-mediated Endosomal Signaling 10.1074/jbc.m112.439950
PAR-1 contributes to the innate immune response during viral infection 10.1172/jci66125
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function 10.1073/pnas.1917295117
GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes 10.1038/s41598-020-69913-z
Signal transduction by protease-activated receptors 10.1111/j.1476-5381.2010.00705.x
The burden of service for faculty of color to achieve diversity and inclusion: the minority tax 10.1091/mbc.e20-08-0567
Subcellular hot spots of GPCR signaling promote vascular inflammation 10.1016/j.coemr.2020.07.011
Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling 10.1016/j.cellsig.2012.11.024
Protease-activated receptor signaling: new roles and regulatory mechanisms 10.1097/moh.0b013e3280dce568
Ubiquitination of G Protein-Coupled Receptors: Functional Implications and Drug Discovery 10.1124/mol.112.079418
Regulation of protease-activated receptor signaling by post-translational modifications 10.1002/iub.442
Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time 10.1124/pharmrev.120.000082
G Protein–Coupled Receptor Sorting to Endosomes and Lysosomes 10.1146/annurev.pharmtox.48.113006.094646
Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer 10.1242/jcs.03409
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus 10.1038/s41467-020-19937-w
Clathrin-Dependent Mechanisms of G Protein-coupled Receptor Endocytosis 10.1111/j.1600-0854.2007.00551.x
Allosteric Modulation of Protease-Activated Receptor Signaling 10.2174/138955712800959116
Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics 10.7554/elife.57410
Phosphorylation of Protease-activated Receptor-2 Differentially Regulates Desensitization and Internalization 10.1074/jbc.m109.048942
Protease-Activated Receptors: New Concepts in Regulation of G Protein-Coupled Receptor Signaling and Trafficking 10.1124/jpet.103.052100
Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion 10.1038/onc.2008.84
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds 10.1073/pnas.1112482108
Caveolae are required for protease-selective signaling by protease-activated receptor-1 10.1073/pnas.0810687106
Protease-Activated Receptor-2 Is Essential for Factor VIIa and Xa–Induced Signaling, Migration, and Invasion of Breast Cancer Cells 10.1158/0008-5472.can-05-1735
AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway 10.1091/mbc.e12-03-0251
Novel Roles for the E3 Ubiquitin Ligase Atrophin-interacting Protein 4 and Signal Transduction Adaptor Molecule 1 in G Protein-coupled Receptor Signaling 10.1074/jbc.m111.336792
Proteases Display Biased Agonism at Protease-Activated Receptors: Location matters! 10.1124/mi.9.2.8
RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling 10.1152/ajpcell.00441.2009
A Tyrosine-based Sorting Signal Regulates Intracellular Trafficking of Protease-activated Receptor-1 10.1074/jbc.m401672200
Dynamic Regulation of Mammalian Numb by G Protein-coupled Receptors and Protein Kinase C Activation: Structural Determinants of Numb Association with the Cortical Membrane 10.1091/mbc.e06-02-0097
The Cloned Thrombin Receptor Is Necessary and Sufficient for Activation of Mitogen-activated Protein Kinase and Mitogenesis in Mouse Lung Fibroblasts 10.1074/jbc.271.35.21536
Multiple Independent Functions of Arrestins in the Regulation of Protease-Activated Receptor-2 Signaling and Trafficking 10.1124/mol.104.006072
ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting 10.1083/jcb.201110031
The Cytoplasmic Tails of Protease-activated Receptor-1 and Substance P Receptor Specify Sorting to LysosomesversusRecycling 10.1074/jbc.274.4.2216
β-Arrestins Regulate Protease-activated Receptor-1 Desensitization but Not Internalization or Down-regulation 10.1074/jbc.m109160200
Adaptor Protein Complex-2 (AP-2) and Epsin-1 Mediate Protease-activated Receptor-1 Internalization via Phosphorylation- and Ubiquitination-dependent Sorting Signals 10.1074/jbc.m111.299776
Internal PDZ Ligands: Novel Endocytic Recycling Motifs for G Protein-Coupled Receptors: TABLE 1 10.1124/mol.105.011288
Persistent Signaling by Dysregulated Thrombin Receptor Trafficking Promotes Breast Carcinoma Cell Invasion 10.1128/mcb.24.5.1990-1999.2004
Protease-activated Receptor-1 Down-regulation 10.1074/jbc.m003770200
A requirement for membrane cholesterol in the  -arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors 10.1242/jcs.02634
Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. 10.1128/mcb.12.10.4742
N-Linked Glycosylation of Protease-activated Receptor-1 Second Extracellular Loop 10.1074/jbc.m110.111088
Thrombin Promotes Release of ATP from Lung Epithelial Cells through Coordinated Activation of Rho- and Ca2+-dependent Signaling Pathways 10.1074/jbc.m109.004762
Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1 10.1083/jcb.200610154
A Role for Sorting Nexin 2 in Epidermal Growth Factor Receptor Down-regulation: Evidence for Distinct Functions of Sorting Nexin 1 and 2 in Protein Trafficking 10.1091/mbc.e03-09-0711
An Essential Role for SNX1 in Lysosomal Sorting of Protease-activated Receptor-1: Evidence for Retromer-, Hrs-, and Tsg101-independent Functions of Sorting Nexins 10.1091/mbc.e05-09-0899
Arrestin-2 Interacts with the Ubiquitin-Protein Isopeptide Ligase Atrophin-interacting Protein 4 and Mediates Endosomal Sorting of the Chemokine Receptor CXCR4 10.1074/jbc.m705085200
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway 10.1016/s0960-9822(02)00546-8
Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2 10.1073/pnas.0409558102
Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis 10.1093/nar/gkn115
Termination of Protease-activated Receptor-1 Signaling by β-Arrestins Is Independent of Receptor Phosphorylation 10.1074/jbc.m310590200
Role of the Thrombin Receptor's Cytoplasmic Tail in Intracellular Trafficking 10.1074/jbc.271.51.32874
Clathrin Adaptor AP2 Regulates Thrombin Receptor Constitutive Internalization and Endothelial Cell Resensitization 10.1128/mcb.26.8.3231-3242.2006
Down-Regulation of Protease-activated Receptor-1 Is Regulated by Sorting Nexin 1 10.1091/mbc.e01-11-0131
Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting 10.1073/pnas.95.23.13698
Cryptic messages: Is noncoagulant tissue factor reserved for cell signaling? 10.1073/pnas.0606888103
Chapter 3 Multiple pathways for signal transduction through the muscarinic cholinergic receptor 10.1016/s0079-6123(08)60885-7
Olivia Molinar-Inglis
Molinar-Inglis Olivia / Olivia Molinar
ORCID: 0000-0002-4974-9608
Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo. 10.1534/genetics.111.133280
Drosophila homologues of adenomatous polyposis coli (APC) and the formin diaphanous collaborate by a conserved mechanism to stimulate actin filament assembly. 10.1074/jbc.M113.462051
Bright Fluorescent Nanotags from Bottlebrush Polymers with DNA-Tipped Bristles. 10.1021/acscentsci.5b00259
APC2 associates with the actin cortex through a multipart mechanism to regulate cortical actin organization and dynamics in the Drosophila ovary. 10.1002/cm.21471
Signaling Diversity Enabled by Rap1-Regulated Plasma Membrane ERK with Distinct Temporal Dynamics 10.1101/781716
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function 10.1073/pnas.1917295117
Subcellular hot spots of GPCR signaling promote vascular inflammation 10.1016/j.coemr.2020.07.011
Jacob Wozniak
Wozniak Jacob
ORCID: 0000-0002-2453-0861
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function 10.1073/pnas.1917295117
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules 10.1016/j.cell.2017.12.032
American Gut: an Open Platform for Citizen Science Microbiome Research 10.1128/msystems.00031-18
Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr 10.1074/mcp.m116.066019
Defining Host Responses during Systemic Bacterial Infection through Construction of a Murine Organ Proteome Atlas 10.1016/j.cels.2018.04.010
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290
Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry 10.1074/mcp.tir118.001099
Optimization of carbon and energy utilization through differential translational efficiency 10.1038/s41467-018-06993-6
EGFR is required for Wnt9a–Fzd9b signalling specificity in haematopoietic stem cells 10.1038/s41556-019-0330-5
Organ-level protein networks as a reference for the host effects of the microbiome 10.1101/gr.256875.119
Quantitative analysis of Mycobacterium avium subsp. hominissuis proteome in response to antibiotics and during exposure to different environmental conditions 10.1186/s12014-019-9260-2
AssessORF: combining evolutionary conservation and proteomics to assess prokaryotic gene predictions 10.1093/bioinformatics/btz714
PTMphinder: an R package for PTM site localization and motif extraction from proteomic datasets 10.7717/peerj.7046
Functional and Proteomic Analysis of Streptococcus pyogenes Virulence Upon Loss of Its Native Cas9 Nuclease 10.3389/fmicb.2019.01967
Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways 10.1371/journal.pntd.0007980
Mortality Risk Profiling of Staphylococcus aureus Bacteremia by Multi-omic Serum Analysis Reveals Early Predictive and Pathogenic Signatures 10.1016/j.cell.2020.07.040
CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly 10.1073/pnas.2018251118
Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption 10.1126/scisignal.abc1044