Crystal structure of a Trypanosoma brucei metacaspase.
McLuskey K Rudolf J Proto WR Isaacs NW Coombs GH Moss CX Mottram JC
Jana Rudolf
Rudolf Jana
ORCID: 0000-0003-1134-2340
Loss of Epidermal HIF-1α Blocks UVB-Induced Tumorigenesis by Affecting DNA Repair Capacity and Oxidative Stress 10.1016/j.jid.2019.01.035
The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway 10.1093/nar/gkp1058
Structure of the DNA Repair Helicase XPD 10.1016/j.cell.2008.04.029
Structure of the heterotrimeric PCNA from Sulfolobus solfataricus. 10.1107/S1744309106034075
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains. 10.1016/j.molcel.2006.07.019
Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition. 10.1038/sj.emboj.7600581
Crystal structure of a Trypanosoma brucei metacaspase. 10.1073/pnas.1200885109
Design and evaluation of Trypanosoma brucei metacaspase inhibitors. 10.1016/j.bmcl.2010.01.099
ERp18 regulates activation of ATF6α during unfolded protein response. 10.15252/embj.2018100990
Proteolytic processing of QSOX1A ensures efficient secretion of a potent disulfide catalyst. 10.1042/BJ20130360
NADPH Oxidases and Their Roles in Skin Homeostasis and Carcinogenesis. 10.1089/ars.2017.7282
Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium 10.1083/jcb.201506065
671 Cross-talk between covalent DNA modifications and chromatin architecture: DNA dioxygenase Tet2 mediates the effects of chromatin architectural protein CTCF on epidermal barrier maintenance, inflammation and tumorigenesis 10.1016/j.jid.2018.03.680
076 Chromatin architectural protein CTCF controls terminal keratinocyte differentiation, epidermal barrier maintenance and suppresses inflammatory responses in the skin 10.1016/j.jid.2017.07.386
098 Chromatin architectural protein CTCF controls keratinocyte differentiation, barrier maintenance and suppresses inflammation and tumorigenesis in the epidermis 10.1016/j.jid.2016.06.116
679 Spatial trans-interactions between lineage-specific gene loci are required for differentiation of the stratified epithelium 10.1038/jid.2015.78
238 ATP-dependent chromatin remodeler Brg1 regulates the establishment of the topological lineage-specific interactome for the Loricrin gene in keratinocytes during epidermal development 10.1038/jid.2014.104
Jeremy Mottram
Mottram Jeremy / Jeremy C. Mottram
ORCID: 0000-0001-5574-3766
High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a. 10.1099/mic.0.059428-0
ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major. 10.1371/journal.ppat.1002695
Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation. 10.1111/j.1462-5822.2012.01798.x
Crystal structure of a Trypanosoma brucei metacaspase. 10.1073/pnas.1200885109
Cytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin. 10.1371/journal.pone.0030367
Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenella. 10.1128/AAC.05528-11
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance. 10.1101/gr.123430.111
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. 10.1101/gr.122945.111
Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor. 10.1074/jbc.M111.292334
Morphological events during the cell cycle of Leishmania major. 10.1128/EC.05118-11
Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3. 10.1002/cmdc.201100344
Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression. 10.1016/j.molimm.2011.05.013
High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase. 10.1371/journal.pntd.0001033
Autophagy in protists. 10.4161/auto.7.2.13310
Trypanosoma brucei brucei: endocytic recycling is important for mouse infectivity. 10.1016/j.exppara.2011.01.001
Trichomonas vaginalis pathobiology new insights from the genome sequence. 10.1016/B978-0-12-391429-3.00006-X
Leishmania inhibitor of serine peptidase 2 prevents TLR4 activation by neutrophil elastase promoting parasite survival in murine macrophages. 10.4049/jimmunol.1002175
Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. 10.1074/jbc.M110.156679
α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB. 10.1002/cmdc.201000265
Oligopeptidase B deficient mutants of Leishmania major. 10.1016/j.molbiopara.2010.09.003
Cathepsin B-like and cell death in the unicellular human pathogen Leishmania. 10.1038/cddis.2010.51
Inhibition of Eimeria tenella CDK-related kinase 2: From target identification to lead compounds. 10.1002/cmdc.201000157
Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210. 10.1186/s13071-015-0974-3
Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. 10.1371/journal.pntd.0003714
An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei. 10.1371/journal.pone.0123241
Comparative structural analysis of the caspase family with other clan CD cysteine peptidases. 10.1042/BJ20141324
The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite. 10.4137/EBO.S13759
Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNFα and IFNβ. 10.1096/fj.13-245126
The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. 10.1371/journal.pgen.1004007
Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen. 10.1371/journal.ppat.1003886
Purification, characterization, and crystallization of Trypanosoma metacaspases. 10.1007/978-1-4939-0357-3_13
Glycosome turnover in Leishmania major is mediated by autophagy. 10.4161/auto.36438
Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase. 10.1371/journal.pntd.0002571
Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB. 10.1371/journal.pone.0077460
Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation. 10.4161/auto.25832
In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. 10.1371/journal.pntd.0002384
Mechanism of Trypanosoma brucei gambiense resistance to human serum. 10.1038/nature12516
Trypanosoma brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. 10.1093/cvr/cvt187
Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei. 10.1371/journal.pone.0067327
Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2. 10.1111/febs.12248
Biochemical and immunological characterization of Toxoplasma gondii macrophage migration inhibitory factor. 10.1074/jbc.M112.419911
Functional analysis of Leishmania cyclopropane fatty acid synthetase. 10.1371/journal.pone.0051300
Cell death in parasitic protozoa: regulated or incidental? 10.1038/nrmicro2929
Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of Leishmania major. 10.1074/jbc.M112.415372
Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells. 10.1038/cddis.2012.113
Imaging of the host/parasite interplay in cutaneous leishmaniasis. 10.1016/j.exppara.2010.05.014
Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions. 10.1128/IAI.00812-09
Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178. 10.1016/j.molbiopara.2010.03.002
Design and evaluation of Trypanosoma brucei metacaspase inhibitors. 10.1016/j.bmcl.2010.01.099
Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response. 10.1128/IAI.00558-08
Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis. 10.1603/033.046.0327
Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen. 10.1186/1756-0500-2-46
Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. 10.4161/auto.5.2.7328
Structures of Leishmania major orthologues of macrophage migration inhibitory factor. 10.1016/j.bbrc.2009.01.030
Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages with Leishmania major. 10.1111/j.1462-5822.2008.01243.x
Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis. 10.1016/j.molbiopara.2008.06.005
The AP3 adaptor is involved in the transport of membrane proteins to acidocalcisomes of Leishmania. 10.1242/jcs.022574
The role of conserved residues of chagasin in the inhibition of cysteine peptidases. 10.1016/j.febslet.2008.01.008
Cytokinesis in trypanosomatids. 10.1016/j.mib.2007.10.005
Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing. 10.1016/j.febslet.2007.11.009
Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases. 10.1016/j.bmcl.2007.09.075
Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence. 10.1111/j.1365-2958.2007.05970.x
An essential role for the Leishmania major metacaspase in cell cycle progression. 10.1038/sj.cdd.4402232
Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. 10.1016/j.febslet.2007.07.072
Trypanosoma brucei Polo-like kinase is essential for basal body duplication, kDNA segregation and cytokinesis. 10.1111/j.1365-2958.2007.05866.x
Comparative genomic analysis of three Leishmania species that cause diverse human disease. 10.1038/ng2053
Protein turnover and differentiation in Leishmania. 10.1016/j.ijpara.2007.03.008
Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. 10.1126/science.1132894
Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5. 10.1186/1471-2199-7-42
Leishmania major metacaspase can replace yeast metacaspase in programmed cell death and has arginine-specific cysteine peptidase activity. 10.1016/j.ijpara.2006.10.004
The SNARE protein family of Leishmania major. 10.1186/1471-2164-7-250
Differentiation of Leishmania major is impaired by over-expression of pyroglutamyl peptidase I. 10.1016/j.molbiopara.2006.09.004
PFPI-like genes are expressed in Leishmania major but are pseudogenes in other Leishmania species. 10.1111/j.1574-6968.2006.00303.x
Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana. 10.1111/j.1365-2958.2006.05274.x
Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine. 10.1074/jbc.M600688200
Bloodstream form Trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes. 10.1242/jcs.02809
Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major. 10.1074/jbc.M512307200
Vaccination with a preparation based on recombinant cysteine peptidases and canine IL-12 does not protect dogs from infection with Leishmania infantum. 10.1016/j.vaccine.2005.12.039
Chemical shift assignments of Leishmania mexicana ICP, a novel cysteine peptidase inhibitor. 10.1007/s10858-005-4739-8
The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors. 10.1074/jbc.M510868200
Specific negative charges in cysteine protease isoforms of Leishmaniamexicana are highly influential on the substrate binding and hydrolysis. 10.1016/j.molbiopara.2005.07.004
Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models. 10.1016/j.vaccine.2005.05.045
Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi. 10.1186/1471-2164-6-127
Protein kinases as drug targets in trypanosomes and Leishmania. 10.1016/j.bbapap.2005.08.018
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. 10.1126/science.1112631
The genome of the kinetoplastid parasite, Leishmania major. 10.1126/science.1112680
Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis. 10.1111/j.1365-2958.2005.04542.x
A potential role for ICP, a Leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite. 10.1111/j.1365-2958.2004.04355.x
Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway. 10.4049/jimmunol.173.5.3297
Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes. 10.1111/j.1432-1033.2004.04311.x
Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity. 10.1128/AAC.48.8.3033-3042.2004
Cysteine peptidases as virulence factors of Leishmania. 10.1016/j.mib.2004.06.010
Generation of Leishmania mutants lacking antibiotic resistance genes using a versatile hit-and-run targeting strategy. 10.1111/j.1574-6968.2004.tb09571.x
Combinatorial library of peptidotriazoles: identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease. 10.1021/cc020085v
The Trypanosoma brucei cyclin, CYC2, is required for cell cycle progression through G1 phase and for maintenance of procyclic form cell morphology. 10.1074/jbc.M401276200
The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system. 10.1074/jbc.M304359200
Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. 10.4049/jimmunol.171.7.3711
The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active site. 10.1074/jbc.M307187200
Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo. 10.1128/IAI.71.6.3190-3195.2003
Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens. 10.1016/S0014-5793(03)00327-2
Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin. 10.1074/jbc.M300813200
Clan CD cysteine peptidases of parasitic protozoa. 10.1016/S1471-4922(03)00038-2
Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8. 10.1091/mbc.E02-03-0167
The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses. 10.4049/jimmunol.170.4.1746
3-Mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism. 10.1074/jbc.M209395200
Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein. 10.1042/BJ20020386
Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis? 10.1038/sj.cdd.4401071
Protein kinases as drug targets in parasitic protozoa. 10.1016/S1471-4922(02)02321-8
Characterisation of the QM gene of Trypanosoma brucei. 10.1111/j.1574-6968.2002.tb11213.x
Processing and trafficking of Leishmania mexicana GP63. Analysis using GP18 mutants deficient in glycosylphosphatidylinositol protein anchoring. 10.1074/jbc.M202047200
Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B. 10.1021/jm0110901
Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor. 10.1074/jbc.M202651200
Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets. 10.1016/S1471-4922(01)02037-2
The stage-regulated expression of Leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element. 10.1074/jbc.M108498200
Analysis of the S(2) subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids. 10.1016/S0166-6851(01)00340-1
Combinatorial library of peptide isosters based on Diels-Alder reactions: identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana. 10.1021/cc0001102
Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana. 10.1016/S0166-6851(01)00290-0
Trifluoromethionine, a prodrug designed against methionine gamma-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalis. 10.1128/AAC.45.6.1743-1745.2001
The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana. 10.1016/S0166-6851(01)00220-1
Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana. 10.1016/S0166-6851(01)00239-0
S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids. 10.1046/j.1432-1327.2001.01973.x
The CYC3 gene of trypanosoma brucei encodes a cyclin with a short half-life. 10.1016/S0166-6851(00)00318-2
Soluble GPI8 restores glycosylphosphatidylinositol anchoring in a trypanosome cell-free system depleted of lumenal endoplasmic reticulum proteins. 10.1042/0264-6021:3510717
Trypanosoma brucei CYC1 does not have characteristics of a mitotic cyclin. 10.1016/S0166-6851(00)00308-X
Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction. 10.1017/S0031182099006435
The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach. 10.1002/1439-7633(20000818)1:2<115::AID-CBIC115>3.3.CO;2-#
Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. 10.1016/S1074-5521(00)00124-1
Stable transformation of trypanosomatids through targeted chromosomal integration of the selectable marker gene encoding blasticidin S deaminase. 10.1111/j.1574-6968.2000.tb09119.x
Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins. 10.1091/mbc.11.4.1183
Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana. 10.1042/0264-6021:3470383
Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leishmania amastigotes. 10.1016/S0166-6851(00)00195-X
Isolation of Trypanosoma brucei CYC2 and CYC3 cyclin genes by rescue of a yeast G(1) cyclin mutant. Functional characterization of CYC2. 10.1074/jbc.275.12.8315
Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif. 10.1074/jbc.274.23.16249
Recent advances in identifying and validating drug targets in trypanosomes and leishmanias. 10.1016/S0966-842X(98)01433-4
Leishmania cysteine proteinases: virulence factors in quest of a function-reply. 10.1016/S0169-4758(98)01251-4
Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions. 10.1016/S1369-5274(98)80065-9
Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus. 10.1046/j.1365-2958.1998.00968.x
The crk3 gene of Leishmania mexicana encodes a stage-regulated cdc2-related histone H1 kinase that associates with p12. 10.1074/jbc.273.17.10153
The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes. 10.1074/jbc.273.10.5549
Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana. 10.1016/S0166-6851(97)00072-8
The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences. 10.1074/jbc.272.22.14285
Plasmodium cdc2-related kinases: Do they regulate stage differentiation? 10.1016/S0169-4758(96)20058-4
Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana. 10.1046/j.1365-2958.1996.00136.x
Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. 10.1073/pnas.93.12.6008
A family of trypanosome cdc2-related protein kinases. 10.1016/0378-1119(95)00350-F
Isolation of lmcpc, a gene encoding a Leishmania mexicana cathepsin-B-like cysteine proteinase. 10.1016/0166-6851(95)00113-F
Antigen presentation by Leishmania mexicana-infected macrophages: activation of helper T cells specific for amastigote cysteine proteinases requires intracellular killing of the parasites. 10.1002/eji.1830250435
cdc2-related protein kinases and cell cycle control in trypanosomatids. 10.1016/0169-4758(94)90136-8
Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana. 10.1016/0166-6851(94)90057-4
Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana. 10.1016/0014-5793(92)81382-V
Characterisation of a gene for a cysteine protease from Theileria annulata. 10.1016/0166-6851(92)90100-X
A developmentally regulated cysteine proteinase gene of Leishmania mexicana. 10.1111/j.1365-2958.1992.tb01365.x
Sequence of a tRNA gene cluster in Trypanosoma brucei. 10.1093/nar/19.14.3995
Conservation of cation-transporting ATPase genes in Leishmania. 10.1016/0166-6851(91)90024-Z
Cysteine proteinases of parasitic protozoa. 10.1016/0169-4758(90)90189-B
Bloodstream and metacyclic variant surface glycoprotein gene expression sites of Trypanosoma brucei gambiense. 10.1016/0166-6851(90)90101-Q
A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension. 10.1016/0014-5793(89)81655-2
A transcriptional analysis of the Trypanosoma brucei hsp83 gene cluster. 10.1016/0166-6851(89)90108-4
Two variant surface glycoprotein genes distinguish between different substrains of Trypanosoma brucei gambiense. 10.1016/0166-6851(89)90005-4
Leishmania mexicana: subcellular distribution of enzymes in amastigotes and promastigotes. 10.1016/0014-4894(85)90081-5
Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals. 10.1016/0014-4894(85)90067-0
Purification of particulate malate dehydrogenase and phosphoenolpyruvate carboxykinase from Leishmania mexicana mexicana. 10.1016/0167-4838(85)90216-X
Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome 10.1074/jbc.M115.706143
RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse 10.1038/s41598-017-06501-8
Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei 10.1371/journal.ppat.1006477
Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects 10.1021/acsinfecdis.7b00244
Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis 10.12688/wellcomeopenres.14867.1
Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification 10.1128/mBio.01399-18
Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis 10.12688/wellcomeopenres.14867.2
TLR2 signaling in skin non-hematopoietic cells induces early neutrophil recruitment in response to Leishmania major infection. 10.1016/j.jid.2018.12.012
Drug Discovery for Kinetoplastid Diseases: Future Directions. 10.1021/acsinfecdis.8b00298
Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania. 10.1093/nar/gky1017
The ATR kinase of Trypanosoma brucei links DNA damage signalling and monoallelic control of surface antigen gene expression during antigenic variation 10.1101/435198
A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis. 10.1016/j.ebiom.2018.09.029
Drug candidate and target for leishmaniasis. 10.1038/d41586-018-05765-y
New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8. 10.1016/j.ejmech.2018.07.012
Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells. 10.1096/fj.201700797R
A DiCre recombinase-based system for inducible expression in Leishmania major. 10.1016/j.molbiopara.2017.06.006
Recent advances in Leishmania reverse genetics: Manipulating a manipulative parasite. 10.1016/j.molbiopara.2017.06.005
The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei. 10.1371/journal.pntd.0005626
Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis. 10.1371/journal.pone.0168074
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness. 10.1038/nature19339
Reduction of Tubulin Expression in Angomonas deanei by RNAi Modifies the Ultrastructure of the Trypanosomatid Protozoan and Impairs Division of Its Endosymbiotic Bacterium. 10.1111/jeu.12326
Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression. 10.1371/journal.ppat.1005658
Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation. 10.1111/mmi.13375
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast. 10.1074/jbc.M116.714972
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 10.1080/15548627.2015.1100356
Tracking autophagy during proliferation and differentiation of Trypanosoma brucei. 10.15698/mic2014.01.120
Leishmaniaflagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the host 10.1073/pnas.1812462116
Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis 10.12688/wellcomeopenres.15606.1
New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story 10.3390/tropicalmed5010029
Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis 10.3390/tropicalmed5010028
Essential roles for deubiquitination in Leishmania life cycle progression 10.1101/2020.03.05.978528
Role for the flagellum attachment zone in the resolution of cell membrane morphogenesis during Leishmania cell division 10.1101/2020.03.26.009928
Essential roles for deubiquitination in Leishmania life cycle progression 10.1371/journal.ppat.1008455
Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex 10.1101/2020.07.09.195024
Role for the flagellum attachment zone in Leishmania anterior cell tip morphogenesis 10.1371/journal.ppat.1008494
Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex 10.1371/journal.ppat.1008784
Chromosomal assembly of the nuclear genome of the endosymbiont-bearing trypanosomatid Angomonas deanei 10.1093/g3journal/jkaa018
Multiple targets of balancing selection in Leishmania donovani complex parasites 10.1101/2021.03.02.433528
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. 10.1038/s41564-020-0745-6
Divergent Cytochrome c Maturation System in Kinetoplastid Protists 10.1128/mBio.00166-21
17-AAG-Induced Activation of the Autophagic Pathway in Leishmania Is Associated with Parasite Death 10.3390/microorganisms9051089
A CLK1-KKT2 Signaling Pathway Regulating Kinetochore Assembly in Trypanosoma brucei 10.1128/mBio.00687-21
Protein kinase signalling at the Leishmania kinetochore captured by XL-BioID 10.1101/2021.07.08.451598
Widespread roles of Trypanosoma brucei ATR in nuclear genome function and transmission are linked to R-loops 10.1101/2021.09.09.459654
Karen McLuskey
McLuskey Karen
ORCID: 0000-0002-9841-4943
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast 10.1074/jbc.M116.714972
Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome 10.1074/jbc.M115.706143
Crystal structures of all-alpha type membrane proteins. 10.1007/s00249-009-0546-6
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. 10.1073/pnas.0704384105
Crystallization and preliminary x-ray crystallographic analysis of the B800-820 light-harvesting complex from Rhodopseudomonas acidophila strain 7050. 10.1107/s0907444998016059
Comparative structural analysis of the caspase family with other clan CD cysteine peptidases. 10.1042/bj20141324
Purification, characterization, and crystallization of Trypanosoma metacaspases. 10.1007/978-1-4939-0357-3_13
Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2. 10.1111/febs.12248
Crystal structure of a Trypanosoma brucei metacaspase. 10.1073/pnas.1200885109
Oligopeptidase B deficient mutants of Leishmania major. 10.1016/j.molbiopara.2010.09.003
The crystal structure of the periplasmic domain of the type II secretion system protein EpsM from Vibrio cholerae: the simplest version of the ferredoxin fold. 10.1016/j.jmb.2004.01.064
Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. 10.1074/jbc.m110.156679
Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensis. 10.1107/s1744309105012376
Insight into the role of Escherichia coli MobB in molybdenum cofactor biosynthesis based on the high resolution crystal structure. 10.1074/jbc.m301485200
Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism. 10.1073/pnas.0504314102
A protocol for high throughput methods for the expression and purification of inner membrane proteins. 10.1080/09687680802510289
High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins. 10.3109/09687688.2011.628954
High-throughput methods for the detection of protein overexpression using fluorescence markers. 10.1016/b978-0-12-407239-8.00010-0
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate. 10.1111/j.1365-2958.2006.05332.x
How purple photosynthetic bacteria harvest solar energy 10.1016/j.crci.2005.03.035
Structural factors which control the position of the Qy absorption band of bacteriochlorophyll a in purple bacterial antenna complexes 10.1023/a:1020995224156
Inhibition ofLeishmania majorpteridine reductase by 2,4,6-triaminoquinazoline: structure of the NADPH ternary complex 10.1107/s0907444904018955
Ranking Metabolite Sets by Their Activity Levels 10.3390/metabo11020103
The crystallographic structure of the B800-820 LH3 light-harvesting complex from the purple bacteria Rhodopseudomonas acidophila strain 7050. 10.1021/bi010309a