A new evolutionary scenario for the Mycobacterium tuberculosis complex
Brosch, R. Gordon, S. V. Marmiesse, M. Brodin, P. Buchrieser, C. Eiglmeier, K. Garnier, T. Gutierrez, C. Hewinson, G. Kremer, K. Parsons, L. M. Pym, A. S. Samper, S. van Soolingen, D. Cole, S. T.
Proceedings of the National Academy of Sciences of the United States of America, 2002
https://doi.org/10.1073/pnas.052548299
Alexander Pym
Pym Alexander
ORCID: 0000-0002-6260-8180
Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis. 10.1016/S0140-6736(14)62002-X
Effective anti-tuberculosis therapy correlates with plasma small RNA. 10.1183/09031936.00221214
Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy. 10.1186/2050-6511-15-61
Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis. 10.1056/NEJMoa1407426
Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility. 10.1128/JCM.02438-14
Multidrug-resistant tuberculosis and culture conversion with bedaquiline. 10.1056/NEJMoa1313865
[In Process Citation]. 10.1016/S0399-077X(14)70062-9
Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX. 10.1016/j.bbrc.2014.04.163
Early versus delayed initiation of highly active antiretroviral therapy for HIV-positive adults with newly diagnosed pulmonary tuberculosis (TB-HAART): a prospective, international, randomised, placebo-controlled trial. 10.1016/S1473-3099(14)70733-9
High rates of potentially infectious tuberculosis and multidrug-resistant tuberculosis (MDR-TB) among hospital inpatients in KwaZulu Natal, South Africa indicate risk of nosocomial transmission. 10.1371/journal.pone.0090868
Randomised pharmacokinetic trial of rifabutin with lopinavir/ritonavir-antiretroviral therapy in patients with HIV-associated tuberculosis in Vietnam. 10.1371/journal.pone.0084866
Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study. 10.1016/S2213-2600(13)70231-5
High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria. 10.1371/journal.pone.0077844
Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial. 10.1016/S0140-6736(13)62073-5
Consensus standards for introductory e-learning courses in human participants research ethics. 10.1136/medethics-2013-101572
EDCTP regional networks of excellence: initial merits for planned clinical trials in Africa. 10.1186/1471-2458-13-258
Compassionate use of and expanded access to new drugs for drug-resistant tuberculosis. 10.5588/ijtld.12.0017
Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide. 10.1073/pnas.1203636109
Reduced antituberculosis drug concentrations in HIV-infected patients who are men or have low weight: implications for international dosing guidelines. 10.1128/AAC.05526-11
Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance. 10.1128/AAC.06126-11
International spread of MDR TB from Tugela Ferry, South Africa. 10.3201/eid1711.110291
Drug-Resistant tuberculosis, KwaZulu-Natal, South Africa, 2001-2007. 10.3201/eid1710.100952
Systematic genetic nomenclature for type VII secretion systems. 10.1371/journal.ppat.1000507
The diarylquinoline TMC207 for multidrug-resistant tuberculosis. 10.1056/NEJMoa0808427
Are survey-based estimates of the burden of drug resistant TB too low? Insight from a simulation study. 10.1371/journal.pone.0002363
Challenges in estimating the total burden of drug-resistant tuberculosis. 10.1164/rccm.200801-175PP
Safety of nevirapine in pregnancy. 10.1111/j.1468-1293.2007.00433.x
Evaluation of new antituberculosis drugs in mouse models. 10.1128/AAC.01246-06
Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis. 10.1371/journal.ppat.0020061
Genomic deletions classify the Beijing/W strains as a distinct genetic lineage of Mycobacterium tuberculosis. 10.1128/JCM.43.7.3185-3191.2005
Does resistance to pyrazinamide accurately indicate the presence of Mycobacterium bovis? 10.1128/JCM.43.7.3530-3532.2005
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. 10.1016/j.tube.2004.09.009
High-throughput method for detecting genomic-deletion polymorphisms. 10.1128/JCM.42.7.2913-2918.2004
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. 10.1038/nm859
Proteome analysis of the plasma membrane of Mycobacterium tuberculosis. 10.1002/cfg.211
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. 10.1046/j.1365-2958.2002.03237.x
Effect of katG mutations on the virulence of Mycobacterium tuberculosis and the implication for transmission in humans. 10.1128/IAI.70.9.4955-4960.2002
A new evolutionary scenario for the Mycobacterium tuberculosis complex. 10.1073/pnas.052548299
Inactivation of the Mycobacterium tuberculosis Nramp orthologue (mntH) does not affect virulence in a mouse model of tuberculosis. 10.1111/j.1574-6968.2002.tb11032.x
The evolution of mycobacterial pathogenicity: clues from comparative genomics. 10.1016/S0966-842X(01)02131-X
Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. 10.1046/j.1365-2958.2001.02427.x
Tools for the population genomics of the tubercle bacilli. 10.1101/gr.169200
Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur. 10.1002/1097-0061(20000630)17:2<111::AID-YEA17>3.0.CO;2-G
The rabbit study: ritonavir and saquinavir in combination in saquinavir-experienced and previously untreated patients. 10.1089/088922299310278
The in vivo effects of combination antiretroviral drug therapy on peripheral blood CD34+ cell colony-forming units from HIV type 1-infected patients. 10.1089/088922299311079
Post DOTS, post genomics: the next century of tuberculosis control. 10.1016/S0140-6736(99)02118-2
Disease progression and survival in HIV-1-infected Africans in London. 10.1097/00002030-199810000-00013
Disease progression and survival following specific AIDS-defining conditions: a retrospective cohort study of 2048 HIV-infected persons in London. 10.1097/00002030-199809000-00006
Pasteurella multocida abcess in an African patient with human immunodeficiency virus infection. 10.1111/j.1469-0691.1997.tb00484.x
Vancouver: optimism, but at a cost. 10.1258/0956462961918257
Reasons for increased incidence of tuberculosis. Audit suggests that undernotification is common. 10.1136/bmj.311.7004.570a
Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics. 10.1016/j.ebiom.2016.05.041
Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance. 10.1038/ng.3548
Assessing Local Risk of Rifampicin-Resistant Tuberculosis in KwaZulu-Natal, South Africa Using Lot Quality Assurance Sampling. 10.1371/journal.pone.0153143
Population pharmacokinetic drug-drug interaction pooled analysis of existing data for rifabutin and HIV PIs. 10.1093/jac/dkv470
Assessing the utility of Xpert(®) MTB/RIF as a screening tool for patients admitted to medical wards in South Africa. 10.1038/srep19391
Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis. 10.1183/13993003.00724-2015
Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis. 10.1128/aac.01195-15
Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal. 10.1371/journal.pmed.1001880
Completeness and Reliability of the Republic of South Africa National Tuberculosis (TB) Surveillance System. 10.1186/s12889-015-2117-3
Treatment of drug-resistant tuberculosis with bedaquiline in a high HIV prevalence setting: an interim cohort analysis. 10.5588/ijtld.14.0944
Test characteristics and potential impact of the urine LAM lateral flow assay in HIV-infected outpatients under investigation for TB and able to self-expectorate sputum for diagnostic testing. 10.1186/s12879-015-0967-z
Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study. 10.1186/s12879-015-0964-2
Fatal nosocomial MDR TB identified through routine genetic analysis and whole-genome sequencing. 10.3201/eid2106.141903
Biomarkers for Tuberculosis Based on Secreted, Species-Specific, Bacterial Small Molecules. 10.1093/infdis/jiv312
Impact of tuberculosis treatment and antiretroviral therapy on serial RD-1-specific quantitative T-cell readouts (QuantiFERON-TB Gold In-Tube), and relationship to treatment-related outcomes and bacterial burden. 10.1016/j.ijid.2015.05.006
A Novel Reporter Phage To Detect Tuberculosis and Rifampin Resistance in a High-HIV-Burden Population. 10.1128/jcm.03530-14
Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis. 10.1186/s12916-017-0947-9
Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance. 10.1128/aac.01461-17
A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide. 10.1038/s41467-017-00721-2
Clofazimine protects against Mycobacterium tuberculosis dissemination in the central nervous system following aerosol challenge in a murine model. 10.1016/j.ijantimicag.2017.08.020
Isoniazid-monoresistant tuberculosis is associated with poor treatment outcomes in Durban, South Africa. 10.5588/ijtld.16.0843
Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells. 10.7554/elife.22028
Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance. 10.1038/ng.3767
Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum. 10.1128/mbio.01023-16
Carmen Buchrieser
Buchrieser Carmen
ORCID: 0000-0003-3477-9190
IroT/mavN, a new iron-regulated gene involved in Legionella pneumophila virulence against amoebae and macrophages 10.1111/1462-2920.12604
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline 10.1038/ncomms5544
The Legionella pneumophila kai operon is implicated in stress response and confers fitness in competitive environments 10.1111/1462-2920.12223
Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell 10.1016/j.tcb.2014.06.002
Legionnaires' disease 10.1007/978-3-642-30144-5_94
Host epigenetic targeting by Legionella pneumophila | Reprogrammation épigénétique des cellules hôtes par Legionella pneumophila 10.1051/medsci/20132910010
Human single-chain urokinase is activated by the omptins PgtE of Salmonella enterica and Pla of Yersinia pestis despite mutations of active site residues 10.1111/mmi.12293
Genome dynamics in Legionella: The basis of versatility and adaptation to intracellular replication 10.1101/cshperspect.a009993
Legionella pneumophila effector RomA uniquely modifies host chromatin to repress gene expression and promote intracellular bacterial replication 10.1016/j.chom.2013.03.004
The Legionella pneumophila orphan sensor kinase LqsT regulates competence and pathogen-host interactions as a component of the LAI-1 circuit 10.1111/j.1462-2920.2012.02889.x
CDNA library construction for next-generation sequencing to determine the transcriptional landscape of legionella pneumophila 10.1007/978-1-62703-161-5-34
Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes 10.1186/1471-2164-13-144
Post-translational modifications of host proteins by Legionella pneumophila: A sophisticated survival strategy 10.2217/fmb.12.9
Legionella pneumophila transcriptional response to chlorine treatment 10.1016/j.watres.2011.11.059
Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection 10.1016/j.humimm.2011.10.014
Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions 10.3389/fmicb.2011.00208
Complete genome sequence of the animal pathogen Listeria ivanovii, which provides insights into host specificities and evolution of the genus Listeria 10.1128/JB.06120-11
Legionella: From protozoa to humans 10.3389/fmicb.2011.00182
Extensive recombination events and horizontal gene transfer shaped the Legionella pneumophila genomes 10.1186/1471-2164-12-536
Fatty acid composition modulates sensitivity of Legionella pneumophila to warnericin RK, an antimicrobial peptide 10.1016/j.bbamem.2010.12.011
Specific real-time PCR for simultaneous detection and identification of Legionella pneumophila serogroup 1 in water and clinical samples 10.1128/AEM.02261-10
GamA is a eukaryotic-like glucoamylase responsible for glycogen- and starch-degrading activity of Legionella pneumophila 10.1016/j.ijmm.2010.08.016
Circadian clock proteins in prokaryotes: Hidden rhythms? 10.3389/fmicb.2010.00130
The origins of eukaryotic-like proteins in Legionella pneumophila 10.1016/j.ijmm.2010.04.016
Listeria rocourtiae sp. nov. 10.1099/ijs.0.017376-0
The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication 10.1111/j.1462-5822.2010.01467.x
Isotopologue profiling of Legionella pneumophila: Role of serine and glucose as carbon substrates 10.1074/jbc.M110.128678
The autoinducer synthase LqsA and putative sensor kinase LqsS regulate phagocyte interactions, extracellular filaments and a genomic island of Legionella pneumophila 10.1111/j.1462-2920.2010.02167.x
Two Important Bacterial Pathogens Causing Community Acquired Pneumonia: Streptococcus pneumoniae and Legionella pneumophila 10.1002/9783527629664.ch6
Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease 10.1371/journal.pgen.1000851
Distinct roles of ppGpp and DksA in Legionella pneumophila differentiation 10.1111/j.1365-2958.2010.07094.x
Update on Legionnaires' disease: Pathogenesis, epidemiology, detection and control: MicroMeeting 10.1111/j.1365-2958.2010.07086.x
A trans-Acting Riboswitch Controls Expression of the Virulence Regulator PrfA in Listeria monocytogenes 10.1016/j.cell.2009.08.046
NeMeSys: A biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis 10.1186/gb-2009-10-10-r110
From functional genomics to systems (micro)biology 10.1016/j.mib.2009.09.001
Molecular mimicry: An important virulence strategy employed by Legionella pneumophila to subvert host functions 10.2217/fmb.09.47
Legionella pneumophila: Population genetics, phylogeny and genomics 10.1016/j.meegid.2009.05.004
Legionella pneumophila - Host interactions: Insights gained from comparative genomics and cell biology 10.1159/000235770
Genome sequence of Vibrio splendidus: An abundant planctonic marine species with a large genotypic diversity 10.1111/j.1462-2920.2009.01918.x
Listeria monocytogenes l-forms respond to cell wall deficiency by modifying gene expression and the mode of division 10.1111/j.1365-2958.2009.06774.x
Two small ncRNAs jointly govern virulence and transmission in Legionella pneumophila 10.1111/j.1365-2958.2009.06677.x
In vivo transcriptional profiling of Listeria monocytogenes and mutagenesis identify new virulence factors involved in infection 10.1371/journal.ppat.1000449
Significant role for ladC in initiation of Legionella pneumophila infection 10.1128/IAI.00209-08
Pathogenomics: An updated European Research Agenda 10.1016/j.meegid.2008.01.005
Multigenome analysis identifies a worldwide distributed epidemic Legionella pneumophila clone that emerged within a highly diverse species 10.1101/gr.7229808
Transcriptional profiling of Legionella pneumophila biofilm cells and the influence of iron on biofilm formation 10.1099/mic.0.2007/008698-0
The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA 10.1111/j.1462-5822.2007.01005.x
Pathogenomics of Listeria spp. 10.1016/j.ijmm.2007.03.016
Legionella pathogenicity: Genome structure, regulatory networks and the host cell response 10.1016/j.ijmm.2007.03.009
Comparative transcriptome analysis of Listeria monocytogenes strains of the two major lineages reveals differences in virulence, cell wall, and stress response 10.1128/AEM.02730-06
Biodiversity of the species Listeria monocytogenes and the genus Listeria 10.1016/j.micinf.2007.05.002
Legionella pneumophila adaptation to intracellular life and the host response: Clues from genomics and transcriptomics 10.1016/j.febslet.2007.05.026
Genetic diversity of Listeria monocytogenes recovered from infected persons and pork, seafood and dairy products on retail sale in France during 2000 and 2001 10.1016/j.ijfoodmicro.2006.09.011
The presence of the internalin gene in natural atypically hemolytic Listeria innocua strains suggests descent from L. monocytogenes 10.1128/AEM.01796-06
Legionella pneumophila - A human pathogen that co-evolved with fresh water protozoa 10.1007/s00018-006-6391-1
Listeria genomics 10.1007/978-0-387-49376-3-3
Specific regions of genome plasticity and genetic diversity of the commensal Escherichia coli A0 34/86 10.1016/j.ijmm.2006.06.007
Use of DNA arrays for the analysis of outbreak-related strains of Listeria monocytogenes 10.1016/j.ijmm.2006.06.002
Growth-phase-dependent mobility of the lvh-encoding region in Legionella pneumophila strain Paris 10.1099/mic.0.29227-0
Involvement of closely related strains of a new clonal group of Listeria monocytogenes in the 1998-99 and 2002 multistate outbreaks of foodborne listeriosis in the United States 10.1089/fpd.2006.3.292
How to become a uropathogen: Comparative genomic analysis of extraintestinal pathogenic Escherichia coli strains 10.1073/pnas.0603038103
Escherichia coli induces DNA double-strand breaks in eukaryotic cells 10.1126/science.1127059
Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila 10.1111/j.1462-5822.2006.00703.x
Genomic diversity and evolution within the species Streptococcus agalactiae 10.1016/j.micinf.2005.11.010
Adaptation of Legionella pneumophila to the host environment: Role of protein secretion, effectors and eukaryotic-like proteins 10.1016/j.mib.2005.12.009
How seryl-phosphorylated HPr inhibits PrfA, a transcription activator of Listeria monocytogenes virulence genes 10.1159/000089650
The genome of the social amoeba Dictyostelium discoideum 10.1038/nature03481
Characterization of the flexible genome complement of the commensal Escherichia coli strain A0 34/86 (O83:K24:H31) 10.1099/mic.0.27469-0
Growth inhibition of Listeria monocytogenes by a nonbacteriocinogenic Carnobacterium piscicola 10.1111/j.1365-2672.2004.02438.x
Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity 10.1038/ng1447
The pathogenicity island-associated K15 capsule determinant exhibits a novel genetic structure and correlates with virulence in uropathogenic Escherichia coli strain 536 10.1128/IAI.72.10.5993-6001.2004
DNA Macroarray for Identification and Typing of Staphylococcus aureus Isolates 10.1128/JCM.42.5.2054-2064.2004
Pathogenomics of mobile genetic elements of toxigenic bacteria 10.1078/1438-4221-00290
CAAT-Box, contigs-Assembly and Annotation Tool-Box for genome sequencing projects 10.1093/bioinformatics/btg490
New Aspects Regarding Evolution and Virulence of Listeria monocytogenes Revealed by Comparative Genomics and DNA Arrays 10.1128/IAI.72.2.1072-1083.2004
The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens 10.1038/nbt886
Transcriptome analysis of Listeria monocytogenes identifies three groups of genes differently regulated by PrfA 10.1046/j.1365-2958.2003.03413.x
Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays 10.1128/JB.185.6.1831-1840.2003
Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease 10.1046/j.1365-2958.2002.03126.x
Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis 10.1046/j.1365-2958.2002.03080.x
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
REALIS: Postgenomic analysis of Listeria monocytogenes 10.1002/cfg.137
Hpt, a bacterial homolog of the microsomal glucose-6-phosphate translocase, mediates rapid intracellular proliferation in Listeria 10.1073/pnas.012363899
Comparative genomics of Listeria species 10.1126/science.1063447
A plague o' both your hosts 10.1038/35097178
The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri 10.1046/j.1365-2958.2000.02179.x
Listeriolysin O as a reporter to identify constitutive and in vivo- inducible promoters in the pathogen Listeria monocytogenes 10.1128/IAI.68.6.3242-3250.2000
The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes 10.1046/j.1365-2958.1998.01124.x
Characterization of Listeria strains isolated from soft cheese 10.1016/0168-1605(93)90220-B
Listeriosis outbreak in France in 1992. Microbial data | Epidémie de listériose en France en 1992 aspects microbiologiques 10.1016/S0399-077X(05)81214-4
Use of pulsed field gel electrophoresis to compare large DNA-restriction fragments of Listeria monocytogenes strains belonging to serogroups 1/2 and 3 10.1016/0168-1605(91)90121-5
The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signaling and gene expression of Legionella pneumophila. 10.1111/mmi.13265
Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery. 10.1002/cm.21256
Bacterial remodelling of the host epigenome: functional role and evolution of effectors methylating host histones. 10.1111/cmi.12463
Small RNAs, 5' UTR elements and RNA-binding proteins in intracellular bacteria: impact on metabolism and virulence. 10.1093/femsre/fuv022
From amoeba to macrophages: exploring the molecular mechanisms of Legionella pneumophila infection in both hosts. 10.1007/82_2013_351
Induction of competence for natural transformation in Legionella pneumophila and exploitation for mutant construction. 10.1007/978-1-62703-161-5_9
Co-immunoprecipitation: protein-RNA and protein-DNA interaction. 10.1007/978-1-62703-161-5_36
Deep sequencing defines the transcriptional map of L. pneumophila and identifies growth phase-dependent regulated ncRNAs implicated in virulence. 10.4161/rna.20270
[What do we learn from the genome of Legionella pneumophila?]. 10.1051/medsci/2005215455
Global analysis of gene expression in an rpoN mutant of Listeria monocytogenes. 10.1099/mic.0.26860-0
Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur. 10.1002/1097-0061(20000630)17:2<111::AID-YEA17>3.0.CO;2-G
Monoclonality or oligoclonality of human herpesvirus 8 terminal repeat sequences in Kaposi's sarcoma and other diseases. 10.1093/jnci/92.9.729
Environmental treasures: co-isolation of the first marine Chlamydiae and its protozoan host. 10.1111/1462-2920.13264
Modulation of Host Autophagy during Bacterial Infection: Sabotaging Host Munitions for Pathogen Nutrition. 10.3389/fimmu.2016.00081
Legionella pneumophila Pathogenesis: Lessons Learned from Genomics 10.1007/978-0-387-70896-6_1
Evolution of Listeria monocytogenes 10.1128/9781555815639.ch41
Genomics of the Opportunistic Pathogen Legionella pneumophila 10.1002/352760801x.ch15
Genome Sequencing and Genomics 10.1128/9781555815660.ch89
Génomique comparative 10.1016/s0924-4204(02)85003-x
Listeria monocytogenes and the Genus Listeria 10.1007/0-387-30744-3_11
What Genomics Has Taught Us about Intracellular Pathogens: the Example of Listeria monocytogenes 10.1128/9781555815530.ch14
Genomics of Listeria monocytogenes and Other Members of the Genus Listeria 10.1128/9781555816902.ch10
Genetic Tools for Use with Listeria monocytogenes 10.1128/9781555816513.ch51
Gene Expression and Virulence in Legionella: the Flagellar Regulon 10.1128/9781555815660.ch79
Legionella pneumophilarestrains autophagy by modulating the host's sphingolipid metabolism 10.1080/15548627.2016.1166325
An improved direct viable count for the enumeration of bacteria in milk 10.1016/0168-1605(93)90167-f
Comparison of the genome sequences of Listeria monocytogenes and Listeria innocua : clues for evolution and pathogenicity 10.1016/s0928-8244(02)00448-0
Interdomain Horizontal Gene Transfer Shaped the Genomes of Legionella pneumophila and Legionella longbeachae 10.1007/978-1-4614-7780-8_11
The Genus Listeria and Listeria monocytogenes 10.1201/9781420015188.ch1
Characterization of an acetyltransferase that detoxifies aromatic chemicals in Legionella pneumophila 10.1042/bj20120528
Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy 10.1073/pnas.1522067113
Genome Plasticity in Legionella pneumophila and Legionella longbeachae: Impact on Host Cell Exploitation 10.1128/9781555817213.ch5
Genetic Diversity of Legionella pneumophila 10.1128/9781555815660.ch86
Subtyping of Listeria monocytogenes serovar 4b by use of low-frequency-cleavage restriction endonucleases and pulsed-field gel electrophoresis 10.1016/0923-2508(91)90080-t
The Legionella pneumophila LetA/LetS Two-Component System Exhibits Rheostat-Like Behavior 10.1128/iai.01107-09
Crystal structure of Legionella pneumophila Lpp1115 / KaiB 10.2210/pdb4kun/pdb
Control of Flagellar Gene Regulation in Legionella pneumophila and Its Relation to Growth Phase 10.1128/jb.00610-09
The Legionella Autoinducer Synthase LqsA Produces an  -Hydroxyketone Signaling Molecule 10.1074/jbc.m801929200
Nicotinic Acid Modulates Legionella pneumophila Gene Expression and Induces Virulence Traits 10.1128/iai.00999-12
Characterization of a Variant of vga(A) Conferring Resistance to Streptogramin A and Related Compounds 10.1128/aac.44.9.2271-2275.2000
Bringing the Genome of Legionella pneumophila to Life: the Transcriptional Program during Infection of Acanthamoeba castellanii 10.1128/9781555815660.ch84
Differentiation of the Major Listeria monocytogenes Serovars by Multiplex PCR 10.1128/jcm.42.8.3819-3822.2004
Synergistic Contribution of the Legionella pneumophila lqs Genes to Pathogen-Host Interactions 10.1128/jb.01002-08
Molecular epidemiology, phylogeny and evolution of Legionella. 10.1016/j.meegid.2016.04.033
Rapid detection and evolutionary analysis of Legionella pneumophila serogroup 1 sequence type 47. 10.1016/j.cmi.2016.11.019
The Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system 10.1371/journal.pgen.1006629
Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila 10.1371/journal.pgen.1006855
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020
Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity 10.21775/cimb.025.081
A Unique cis -Encoded Small Noncoding RNA Is Regulating Legionella pneumophila Hfq Expression in a Life Cycle-Dependent Manner 10.1128/mbio.02182-16
MAMs are attractive targets for bacterial repurposing of the host cell 10.1002/bies.201600171
Legionella longbeachae is immunologically silent and highly virulent in vivo 10.1093/infdis/jiw560
Multiple major disease-associated clones of Legionella pneumophila have emerged recently and independently 10.1101/gr.209536.116
Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires’ disease 10.1186/s13059-014-0505-0
Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity 10.21775/9781910190692.04
Legionella pneumophila CsrA regulates a metabolic switch from amino acid to glycerolipid metabolism 10.1098/rsob.170149
Intracellular parasitism, the driving force of evolution of Legionella pneumophila and the genus Legionella 10.1038/s41435-019-0074-z
Editorial: Pathogens and disease special issue ETOX18 10.1093/femspd/fty091
Legionella Effectors Explored with INSeq: New Functional Insights 10.1016/j.tim.2018.01.003
A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins 10.1101/323253
A Comprehensive Review on the Manipulation of the Sphingolipid Pathway by Pathogenic Bacteria 10.3389/fcell.2019.00168
A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins 10.1038/s41467-019-09023-1
Legionella pneumophila infection and antibiotic treatment engenders a highly disturbed pulmonary microbiome with decreased microbial diversity 10.1101/808238
Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism? 10.1111/febs.14446
Editorial overview: Host–pathogen interactions shaped through evolutionary and regulatory processes 10.1016/j.mib.2018.02.001
Sorting of Phagocytic Cells Infected with Legionella pneumophila 10.1007/978-1-4939-9048-1_11
Analysis of the Pulmonary Microbiome Composition of Legionella pneumophila-Infected Patients 10.1007/978-1-4939-9048-1_27
Mitochondrial Dynamics and Activity in Legionella-Infected Cells 10.1007/978-1-4939-9048-1_13
Symbiont-Mediated Defense against Legionella pneumophila in Amoebae 10.1128/mbio.00333-19
Intracellular parasitism, the driving force of evolution of Legionella pneumophila and the genus Legionella 10.1016/j.micinf.2019.06.012
Evolutionary Dissection of the Dot/Icm System Based on Comparative Genomics of 58 Legionella Species 10.1093/gbe/evz186
Metabolic reprogramming: an innate cellular defence mechanism against intracellular bacteria? 10.1016/j.coi.2019.05.009
The Life Cycle of L. pneumophila: Cellular Differentiation Is Linked to Virulence and Metabolism 10.3389/fcimb.2018.00003
Biological Diversity and Evolution of Type IV Secretion Systems 10.1007/978-3-319-75241-9_1
The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection 10.1016/j.jmb.2018.04.032
Legionnaires’ Disease: State of the Art Knowledge of Pathogenesis Mechanisms of Legionella 10.1146/annurev-pathmechdis-012419-032742
The pleiotropic Legionella transcription factor LvbR links the Lqs and c‐di‐GMP regulatory networks to control biofilm architecture and virulence 10.1111/1462-2920.14523
Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL 10.1111/cmi.12852
More than 18,000 effectors in theLegionellagenus genome provide multiple, independent combinations for replication in human cells 10.1073/pnas.1808016116
Celebrating the career and legacy of Professor Pascale Cossart 10.1111/mmi.14478
Persistent Legionnaires’ Disease and Associated Antibiotic Treatment Engender a Highly Disturbed Pulmonary Microbiome Enriched in Opportunistic Microorganisms 10.1128/mBio.00889-20
Danger-associated metabolic modifications during bacterial infection of macrophages 10.1093/intimm/dxaa035
Evolution and function of bacterial RCC1 repeat effectors 10.1111/cmi.13246
Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by Legionella 10.1128/mBio.01201-20
The unique Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins 10.1101/2021.04.23.441069
Reverting the mode of action of the mitochondrial FOF1-ATPase by Legionella pneumophila preserves its replication niche 10.1101/2021.05.12.443790
Priscille Brodin
Brodin Priscille
ORCID: 0000-0003-0991-7344
Email: priscille.brodin@inserm.fr
How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011
Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227 10.3390/toxins9070227.
Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections 10.2217/nnm-2016-0364
Cyclodextrin-based nanocarriers containing a synergic drug combination: a potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030 10.1016/j.ijpharm.2017.05.030.
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z
Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005 10.1016/j.drudis.2017.05.005.
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535
Impact of pe_ pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis 10.3389/fcimb.2017.00137
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129 10.1002/cyto.a.23129.
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5
Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization 10.1016/j.str.2016.07.009
Mycolactone The amazing analgesic mycobacterial toxin 10.1051/medsci/20163202007
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650
High content screening in chemical biology: overview and main challenges 10.1051/medsci/20153102016
High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis 10.1128/aac.03705-14
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438
Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15
Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays 10.1007/978-1-4939-2450-9_24
A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening 10.3791/51114
Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/jm500422b
Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040
Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022
A novel specific edge effect correction method for RNA interference screenings 10.1093/bioinformatics/btr648
Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779
Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u
The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence 10.1371/journal.pone.0047573
Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis 10.1371/journal.pone.0026675
Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200076a
High-content screening in infectious diseases 10.1016/j.cbpa.2011.05.023
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ 10.1099/mic.0.038133-0
High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100
High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery 10.4155/fmc.10.223
Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting 10.1016/j.biomaterials.2009.09.044
Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure 10.1177/1087057108328762
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis 10.1126/science.1171583
High Content Screening Identifies Decaprenyl-Phosphoribose 2 ' Epimerase as a Target for Intracellular Antimycobacterial Inhibitors 10.1371/journal.ppat.1000645
Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507
Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033
Aquatic insects and transmission of Mycobacterium ulcerans 10.1051/medsci/20072367572
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 10.1128/jb.00469-07
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis 10.1371/journal.ppat.0030062
Protection against mycobacterium ulcerans lesion development by exposure to aquatic insect saliva 10.1371/journal.pmed.0040064
Support vector machines for automatic detection of tuberculosis bacteria in confocal microscopy images 10.1109/isbi.2007.356794
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues 10.1016/j.bmc.2006.12.009
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis 10.1128/iai.74.4.2128-2137.2006
Benzofuro 3,2-f 1 benzopyrans: A new class of antitubercular agents 10.1016/j.bmc.2006.03.033
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/iai.74.1.88-98.2006
High frequency of CD4(+) T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection 10.1128/iai.02086-05
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence 10.1128/jb.00631-06
Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis 10.1016/j.tube.2004.09.009
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200
Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics 10.1099/mic.0.27799-0
Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions 10.1016/j.jmb.2005.05.049
Tuberculosis: from genome to vaccine 10.1586/14760584.4.4.541
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6 10.1128/iai.72.4.2170-2176.2004
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468
ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex 10.1099/mic.0.26662-0
CD8(+)-T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family 10.1128/iai.71.12.7173-7177.2003
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/nm859
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant 10.1128/iai.70.10.5568-5578.2002
Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides 10.1021/bi015732y
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x
6-Oxocytidine containing oligonucleotides inhibit the HIV-1 integrase in vitro 10.1081/ncn-100002322
Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase 10.1021/bi000398b
Inhibition of the human immunodeficiency virus type 1 DNA integration by modified oligonucleotides 10.1023/a:1026631910681
Branched oligonucleotide-intercalator conjugate forming a parallel stranded structure inhibits HIV-1 integrase 10.1016/s0014-5793(99)01350-2
Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides 10.1080/07328319908044831
Optimization of alternate-strand triple helix formation at the 5 '-TpA-3 ' and 5 '-ApT-3 ' junctions 10.1093/nar/27.15.3029
A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus 10.1074/jbc.272.25.16010
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371 10.15252/embr.201744371.
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017 10.1016/j.mib.2017.11.017.
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101 10.1016/j.celrep.2017.08.101.
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114 10.1073/pnas.1707840114.
Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry 10.1128/jvi.01982-17
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125
Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025
Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation 10.3389/fimmu.2018.00086
Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis 10.1128/aac.00359-18
The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030
Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101
Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129
A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening 10.1002/cyto.a.20627
Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation 10.1074/mcp.RA119.001316
Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902
Mitochondrial Dynamics and Activity in Legionella-Infected Cells 10.1007/978-1-4939-9048-1_13
Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258
Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication 10.1128/jvi.02009-18
A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J
Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls 10.3390/toxins11090516
Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies. 10.3389/fimmu.2020.569127
Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity. 10.1021/acsinfecdis.9b00277
Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds. 10.1371/journal.pone.0227224
Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis. 10.1016/j.vaccine.2019.11.085
IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551
Worms' Antimicrobial Peptides. 10.3390/md17090512
Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. 10.1371/journal.pone.0198226
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570
Cell microbiology interview 10.1111/cmi.13288
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505
Sofia Samper
Samper Sofia
ORCID: 0000-0002-3011-2519
Rapid test for identification of a highly transmissible Mycobacterium tuberculosis beijing strain of sub-Saharan origin 10.1128/JCM.06314-11
Molecular characterisation of Mycobacterium tuberculosis isolates in the first national survey of anti-tuberculosis drug resistance from Venezuela 10.1186/1471-2180-6-90
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
Mycobacterium tuberculosis genotypes and predominant clones among the multidrug-resistant isolates in Spain 1998–2005 10.1016/j.meegid.2017.08.003
Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosis strain 10.1186/1471-2466-9-3
A Specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies whiB6 as a novel ESX-1 component 10.1128/IAI.01824-14
Recurrent tuberculosis from 1992 to 2004 in a metropolitan area 10.1183/09031936.00005107
In-depth analysis of the genome sequence of a clinical, extensively drug-resistant Mycobacterium bovis strain 10.1016/j.tube.2016.06.005
Peritoneal tuberculosis due to Mycobacterium caprae 10.1016/j.idcr.2016.02.010
Multidrug-resistant Mycobacterium tuberculosis strain from equatorial guinea detected in spain 10.3201/eid1511.090449
Mycobacterium simiae pulmonary infection unmasked during immune reconstitution in an HIV patient 10.1016/j.diagmicrobio.2012.09.004
Detection of multidrug-resistant Mycobacterium tuberculosis in a pediatric patient with choroiditis | Deteccin de Mycobacterium tuberculosis multirresistente en un paciente peditrico con coroiditis 10.1016/j.eimc.2009.10.003
Diagnostic accuracy study of multiplex PCR for detecting tuberculosis drug resistance 10.1016/j.jinf.2015.03.011
Second worldwide proficiency study on variable number of tandem repeats typing of Mycobacterium tuberculosis complex 10.5588/ijtld.13.0531
IS-seq: a novel high throughput survey of in vivo IS6110 transposition in multiple Mycobacterium tuberculosis genomes 10.1186/1471-2164-13-249
First insights into the genetic diversity of Mycobacterium tuberculosis isolates from HIV-infected Mexican patients and mutations causing multidrug resistance 10.1186/1471-2180-10-82
Long-term molecular surveillance of multidrug-resistant tuberculosis in Spain 10.1016/j.meegid.2011.05.016
Research priorities for HIV/M. tuberculosis co-infection 10.2174/1874279301105010014
Epidemiology of tuberculosis on Gran Canaria: A 4 year population study using traditional and molecular approaches 10.1136/thorax.58.7.618
Role of wild bird and rodents in the epidemiology of subclinical salmonellosis in finishing pigs 10.1089/fpd.2014.1755
Pyrosequencing for rapid detection of Mycobacterium tuberculosis second-line drugs and ethambutol resistance 10.1016/j.diagmicrobio.2015.07.004
Molecular characterization of mycobacterium tuberculosis strains with TB-SPRINT 10.4269/ajtmh.16-0782
Global study of is6110 in a successful mycobacterium tuberculosis strain: Clues for deciphering its behavior and for its rapid detection 10.1128/JCM.00970-13
Pyrosequencing for rapid molecular detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis strains and clinical specimens 10.1128/JCM.01239-11
Analysis of mutations in streptomycin-resistant strains reveals a simple and reliable genetic marker for identification of the Mycobacterium tuberculosis Beijing genotype 10.1128/JCM.01944-12
Erratum: Evaluation of genoflow DR-MTB array test for detection of rifampin and isoniazid resistance in mycobacterium tuberculosis (Journal of Clinical Microbiology (2016) 54:4 (1160-1163)) 10.1128/JCM.01181-16
PyroTyping, a novel pyrosequencing-based assay for Mycobacterium tuberculosis genotyping 10.1038/s41598-017-06760-5
Low dose aerosol fitness at the innate phase of murine infection better predicts virulence amongst clinical strains of Mycobacterium tuberculosis 10.1371/journal.pone.0029010
Rapid diagnosis of tuberculosis. Detection of drug resistance mechanisms | Diagnóstico rápido de la tuberculosis. Detección de mecanismos de resistencia 10.1016/j.eimc.2017.01.015
Reply to «Emergent strains of rifampicin-resistant Mycobacterium tuberculosis complex and susceptibility to isoniazid» | Réplica a «Emergencia de aislados de Mycobacterium tuberculosis complex resistentes a rifampicina y sensibles a isoniazida» 10.1016/j.eimc.2014.05.019
AID TB resistance line probe assay for rapid detection of resistant Mycobacterium tuberculosis in clinical samples 10.1016/j.jinf.2014.09.010
Molecular characterization of Mycobacterium tuberculosis complex isolates from wild ungulates in south-central Spain 10.1051/vetres:2004051
GenoType MTBDRsl for molecular detection of second-line-drug and ethambutol resistance in Mycobacterium tuberculosis strains and clinical samples 10.1128/JCM.05274-11
An essential role for phoP in Mycobacterium tuberculosis virelence 10.1046/j.1365-2958.2001.02500.x
Genomic typing of M. tuberculosis strains with few IS6110 copies: Usefulness of amplified fragment length polymorphism (AFLP), variable number tandem repeat (VNTR) and spoligotyping [2] | Caracterización genómica de cepas de M. tuberculosis con menos de 5 copias de IS6110: Utilidad de AFLP, VNTR y spoligotyping 10.1157/13070459
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237 10.1016/j.tube.2010.12.007
Proposal of a consensus set of hypervariable mycobacterial interspersed repetitive-unit-variable-number tandem-repeat loci for subtyping of mycobacterium tuberculosis Beijing isolates 10.1128/JCM.02519-13
Mycobacterium mageritense sp. nov. 10.1099/00207713-47-2-535
Transmission between HIV-infected patients of multidrug-resistant tuberculosis caused by Mycobacterium bovis 10.1097/00002030-199710000-00006
Conspicuous multidrug-resistant Mycobacterium tuberculosis cluster strains do not trespass country borders in Latin America and Spain 10.1016/j.meegid.2011.06.006
Mycobacterium tuberculosis complex genetic diversity: Mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology 10.1186/1471-2180-6-23
Systematic molecular characterization of multidrug-resistant Mycobacterium tuberculosis complex isolates from Spain 10.1128/JCM.43.3.1220-1227.2005
Multidrug-resistant Mycobacterium tuberculosis Beijing/W genotype in Venezuela [3] 10.1099/jmm.0.47310-0
Characterization of Mycobacterium tuberculosis Beijing isolates from the Mediterranean area 10.1186/1471-2180-10-151
Single nucleotide polymorphism (SNP) analysis used for the phylogeny of the Mycobacterium tuberculosis complex based on a pyrosequencing assay 10.1186/1471-2180-14-21
Epidemiology of subclinical salmonellosis in wild birds from an area of high prevalence of pig salmonellosis: Phenotypic and genetic profiles of salmonella isolates 10.1111/j.1863-2378.2012.01542.x
High rate of tuberculosis reinfection during a nosocomial outbreak of multidrug-resistant tuberculosis caused by Mycobacterium bovis strain B 10.1086/317547
Mapping IS6110 in high-copy number Mycobacterium tuberculosis strains shows specific insertion points in the Beijing genotype 10.1186/1471-2164-14-422
In Vivo IS6110 profile changes in a Mycobacterium tuberculosis strain as determined by tracking over 14 years 10.1128/JCM.00607-15
Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage 10.1038/ng.3195
First worldwide proficiency study on variable-number tandem-repeat typing of Mycobacterium tuberculosis complex strains 10.1128/JCM.00607-11
IS6110 Mediates Increased Transcription of the phoP Virulence Gene in a Multidrug-Resistant Clinical Isolate Responsible for Tuberculosis Outbreaks 10.1128/JCM.42.1.212-219.2004
Mycobacterial diversity causing multi-and extensively drugresistant tuberculosis in Djibouti, Horn of Africa 10.5588/ijtld.15.0268
Evaluation of GenoFlow DR-MTB array test for detection of rifampin and isoniazid resistance in mycobacterium tuberculosis 10.1128/JCM.03341-15
Data-driven model for the assessment of Mycobacterium tuberculosis transmission in evolving demographic structures 10.1073/pnas.1720606115
New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages 10.1371/journal.pgen.1007282
Investigation of a rapidly spreading tuberculosis outbreak using whole-genome sequencing 10.1016/j.meegid.2020.104184
Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential 10.1016/j.ebiom.2020.102761
Stephen Gordon
Gordon Stephen
ORCID: 0000-0002-4833-5542
Innate cytokine profiling of bovine alveolar macrophages reveals commonalities and divergence in the response to Mycobacterium bovis and Mycobacterium tuberculosis infection 10.1016/j.tube.2014.04.004
Iron-regulated protein HupB of Mycobacterium tuberculosis positively regulates siderophore biosynthesis and is essential for growth in macrophages 10.1128/JB.01483-13
The synthesis and biological evaluation of mycobacterial p-hydroxybenzoic acid derivatives (p-HBADs) 10.1039/c3ob42277a
Relaxed selection drives a noisy noncoding transcriptome in members of the Mycobacterium tuberculosis complex 10.1128/mBio.01169-14
RNA-seq transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis 10.3389/fimmu.2014.00396
The phylogeny and population structure of Mycobacterium bovis in the British Isles 10.1016/j.meegid.2013.08.003
Profiling microRNA expression in bovine alveolar macrophages using RNA-seq 10.1016/j.vetimm.2013.08.004
Tuberculosis 2012: Biology, pathogenesis and intervention strategies; an update from the city of light 10.1016/j.resmic.2012.12.006
Mycobacterial lineages causing pulmonary and extrapulmonary Tuberculosis, Ethiopia 10.3201/eid1903.120256
Database resources for the tuberculosis community 10.1016/j.tube.2012.11.003
Genome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expression 10.1186/1471-2164-14-710
Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro 10.1186/1471-2164-14-230
European 2--a clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula. 10.1016/j.meegid.2011.09.004
Two novel methods for using genome sequences to infer taxonomy 10.1099/mic.0.059816-0
A point mutation in cycA partially contributes to the D-cycloserine resistance trait of Mycobacterium bovis BCG vaccine strains 10.1371/journal.pone.0043467
High Prevalence of Bovine Tuberculosis in Dairy Cattle in Central Ethiopia: Implications for the Dairy Industry and Public Health 10.1371/journal.pone.0052851
Global gene expression and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro challenge with mycobacterium bovis 10.1371/journal.pone.0032034
European 1: A globally important clonal complex of Mycobacterium bovis 10.1016/j.meegid.2011.04.027
Exploring the use of molecular epidemiology to track bovine tuberculosis in Nigeria: An overview from 2002 to 2004 10.1016/j.vetmic.2011.02.036
Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle 10.1016/j.vetmic.2011.02.020
Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus 10.1111/mmi.12387
Mycobacterium tuberculosis infection in grazing cattle in central Ethiopia 10.1016/j.tvjl.2010.05.005
African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa 10.1128/JB.00750-10
Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes 10.1186/1471-2164-12-611
Molecular epidemiology of Mycobacterium tuberculosis clinical isolates in Southwest Ireland 10.1016/j.meegid.2010.07.008
Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue 10.1099/mic.0.037200-0
Screening of predicted secreted antigens from Mycobacterium bovis reveals the immunodominance of the ESAT-6 protein family 10.1128/IAI.01246-09
Revisiting host preference in the Mycobacterium tuberculosis complex: Experimental infection shows M. tuberculosis H37Rv to be avirulent in cattle 10.1371/journal.pone.0008527
Global effects of inactivation of the pyruvate kinase gene in the Mycobacterium tuberculosis complex 10.1128/JB.00619-09
Differential transcriptome profiles of attenuated and hypervirulent strains of Mycobacterium bovis 10.1016/j.micinf.2009.06.006
Antigen mining to define Mycobacterium bovis Antigens for the differential diagnosis of vaccinated and infected animals: A VLA perspective 10.1111/j.1865-1682.2009.01070.x
Mce3R, a TetR-type transcriptional repressor, controls the expression of a regulon involved in lipid metabolism in mycobacterium tuberculosis 10.1099/mic.0.027086-0
Myths and misconceptions: The origin and evolution of Mycobacterium tuberculosis 10.1038/nrmicro2165
A comprehensive survey of single nucleotide polymorphisms (SNPs) across Mycobacterium bovis strains and M. bovis BCG vaccine strains refines the genealogy and defines a minimal set of SNPs that separate virulent M. bovis strains and M. bovis BCG strains 10.1128/IAI.01099-08
Pathogenicity in the tubercle bacillus: Molecular and evolutionary determinants 10.1002/bies.200800191
African 1, an epidemiologically important clonal complex of mycobacterium bovis dominant in Mali, Nigeria, Cameroon, and Chad 10.1128/JB.01590-08
Gene expression profiling and antigen mining of the tuberculin production strain Mycobacterium bovis AN5 10.1016/j.vetmic.2008.07.004
The burden of mycobacterial disease in Ethiopian cattle: Implications for public health 10.1371/journal.pone.0005068
Bovine TB: Stopping disease control would block all live exports 10.1038/456700b
Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism 10.1099/mic.0.2008/022269-0
Mycobacterium bovis strains causing smear-positive human tuberculosis, southwest Ireland 10.3201/eid1412.071135
Characterization of two in vivo-expressed methyltransferases of the Mycobacterium tuberculosis complex: antigenicity and genetic regulation. 10.1099/mic.0.2007/014548-0
Comparative transcriptomics reveals key gene expression differences between the human and bovine pathogens of the Mycobacterium tuberculosis complex 10.1099/mic.0.2007/009894-0
Genome plasticity of BCG and impact on vaccine efficacy 10.1073/pnas.0700869104
Field evaluation of a novel differential diagnostic reagent for detection of Mycobacterium bovis in cattle 10.1128/CVI.00209-06
Metabolic fingerprints of Mycobacterium bovis cluster with molecular type: Implications for genotype-phenotype links 10.1099/mic.0.28986-0
Bottlenecks and broomsticks: The molecular evolution of Mycobacterium bovis 10.1038/nrmicro1472
Ecotypes of the Mycobacterium tuberculosis complex 10.1016/j.jtbi.2005.08.036
Recent advances in our knowledge of Mycobacterium bovis: A feeling for the organism 10.1016/j.vetmic.2005.11.050
Antigen mining with iterative genome screens identifies novel diagnostics for the Mycobacterium tuberculosis complex 10.1128/CVI.13.1.90-97.2006
Molecular analysis of human and bovine tubercle bacilli from a local setting in Nigeria 10.1128/JCM.44.1.29-34.2006
Revisiting the evolution of Mycobacterium bovis 10.1128/JB.187.18.6386-6395.2005
Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6 10.1038/sj.emboj.7600732
Identification of genetic markers for Mycobacterium pinnipedii through genome analysis 10.1016/j.femsle.2005.05.034
The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: Implications for in vivo growth 10.1111/j.1365-2958.2005.04524.x
Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic mycobacteria 10.1074/jbc.M412540200
Sequence-specific assignment and secondary structure determination of the 195-residue complex formed by the Mycobacterium tuberculosis proteins CFP-10 and ESAT-6. 10.1023/B:JNMR.0000048852.40853.5c
Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility. 10.1111/j.1574-6968.2004.tb09764.x
Genotypic Analysis of Mycobacterium tuberculosis in Bangladesh and Prevalence of the Beijing Strain 10.1128/JCM.42.2.674-682.2004
Advanced significance analysis of microarray data based on weighted resampling: A comparative study and application to gene deletions in Mycobacterium bovis 10.1093/bioinformatics/btg417
Microarray analysis of Mycobacterium microti reveals deletion of genes encoding PE-PPE proteins and ESAT-6 family antigens 10.1016/j.tube.2003.12.002
The population structure of Mycobacterium bovis in Great Britain: Clonal expansion 10.1073/pnas.2036554100
Genetic composition of Mycobacterium bovis BCG substrain Sofia. 10.1128/JCM.41.11.5349.2003
Solution Structure of the Mycobacterium tuberculosis Complex Protein MPB70: From tuberculosis pathogenesis to inherited human corneal disease 10.1074/jbc.M307235200
Genomic analysis of Mycobacterium tuberculosis complex strains used for production of purified protein derivative 10.1128/JCM.41.8.3929-3932.2003
The complete genome sequence of Mycobacterium bovis 10.1073/pnas.1130426100
Inactivation of the Mycobacterium bovis homologue of the polymorphic RD1 gene Rv3879c (Mb3909c) does not affect virulence 10.1016/j.tube.2003.08.018
Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics 10.1128/IAI.70.12.6996-7003.2002
Microarray-based comparative genomics: Genome plasticity in Mycobacterium bovis 10.1002/cfg.182
Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6·CFP-10 complex. Implications for pathogenesis and virulence 10.1074/jbc.M201625200
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo 10.1046/j.1365-2958.2002.02771.x
Royal society of tropical medicine and hygiene meeting at Manson house, London, 18 January 2001: Pathogen genomes and human health. Mycobacterial genomics 10.1016/S0035-9203(02)90222-1
The evolution of mycobacterial pathogenicity: Clues from comparative genomics 10.1016/S0966-842X(01)02131-X
Genomics of Mycobacterium bovis 10.1054/tube.2000.0269
Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur. 10.1002/1097-0061(20000630)17:2<111::AID-YEA17>3.0.CO;2-G
Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays 10.1046/j.1365-2958.1999.01383.x
Analysis of the proteome of Mycobacterium tuberculosis in silico 10.1054/tuld.1999.0220
Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence 10.1038/31159
Response of Mycobacterium smegmatis to acid stress 10.1016/0378-1097(96)00098-5
Why doesn't Mycobacterium tuberculosis spread in animals? 10.1016/j.tim.2014.11.001
Comparative functional genomics and the bovine macrophage response to strains of the mycobacterium genus 10.3389/fimmu.2014.00536
Key hub and bottleneck genes differentiate the macrophage response to virulent and attenuated Mycobacterium bovis 10.3389/fimmu.2014.00422
The Application of Bacterial Luciferase as a Reporter Gene in Mycobacteria 10.1385/0-89603-471-2:235
Comparative genomics of the leprosy and tubercle bacilli 10.1016/S0923-2508(00)00117-0
Comparison of tuberculin activity using the interferon-γ assay for the diagnosis of bovine tuberculosis 10.1136/vr.c3403
High prevalence and increased severity of pathology of bovine tuberculosis in holsteins compared to zebu breeds under field cattle husbandry in central Ethiopia 10.1128/CVI.00205-07
Pathogenomics: Insights into Tuberculosis and Related Mycobacterial Diseases 10.1002/352760801X.ch10
Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: Towards an understanding of the rules governing complex formation and thereby functional flexibility 10.1016/j.femsle.2004.07.043
RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli 10.1038/srep13629
The identification of circulating MiRNA in bovine serum and their potential as novel biomarkers of early mycobacterium avium subsp paratuberculosis infection 10.1371/journal.pone.0134310
Epitopemap: A web application for integrated whole proteome epitope prediction 10.1186/s12859-015-0659-0
MicroRNA profiling of the bovine alveolar macrophage response to Mycobacterium bovis infection suggests pathogen survival is enhanced by microRNA regulation of endocytosis and lysosome trafficking 10.1016/j.tube.2014.10.011
Influence of cohabitation between domestic goat (Capra aegagrus hircus) and Iberian ibex (Capra pyrenaica hispanica) on seroprevalence of infectious diseases 10.1007/s10344-013-0785-9
African 2, a Clonal Complex of Mycobacterium bovis Epidemiologically Important in East Africa 10.1128/JB.00048-12
Erratum: Genotypic Analysis of Mycobacterium tuberculosis in Bangladesh and Prevalence of the Beijing Strain (Journal of Clinical Microbiology (2004) 42, 2 (674-682)) 10.1128/JCM.42.4.1861.2004
Rapid measurement of antimycobacterial drug activity 10.1016/0923-2508(96)80208-7
GOexpress: an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data. 10.1186/s12859-016-0971-3
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. 10.1016/j.immuni.2016.01.019
Analysis of Biobanked Serum from a Mycobacterium avium subsp paratuberculosis Bovine Infection Model Confirms the Remarkable Stability of Circulating miRNA Profiles and Defines a Bovine Serum miRNA Repertoire. 10.1371/journal.pone.0145089
70th Anniversary Collection for the Microbiology Society: Microbiology. 10.1099/mic.0.000188
The MarR family transcription factor Rv1404 coordinates adaptation of Mycobacterium tuberculosis to acid stress via controlled expression of Rv1405c, a virulence-associated methyltransferase. 10.1016/j.tube.2015.10.003
Potential application of emerging diagnostic techniques to the diagnosis of bovine Johne's disease (paratuberculosis). 10.1016/j.tvjl.2015.10.033
Tuberculosis Caused by Mycobacterium orygis in Dairy Cattle and Captured Monkeys in Bangladesh: a New Scenario of Tuberculosis in South Asia. 10.1111/tbed.12596
Agricultural anaerobic digestion power plants in Ireland and Germany: policy & practice. 10.1002/jsfa.8005
Updated Reference Genome Sequence and Annotation of Mycobacterium bovis AF2122/97 10.1128/genomeA.00157-17
The bovine alveolar macrophage DNA methylome is resilient to infection with Mycobacterium bovis 10.1101/238816
Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle 10.1038/s41598-017-18575-5
Updated reference genome sequence and annotation of Mycobacterium bovis AF2122/97 10.1101/092122
Comparative ’omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilli 10.1101/220624
Integrated computational prediction and experimental validation identifies promiscuous T cell epitopes in the proteome of Mycobacterium bovis 10.1099/mgen.0.000071
Post-genomic Antigen Discovery: Bioinformatical Approaches to Reveal Novel T Cell Antigens of Mycobacterium bovis 10.1007/978-1-4614-5070-2_4
Antibiotic Methylation: A New Mechanism of Antimicrobial Resistance 10.1016/j.tim.2016.08.003
TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development. 10.3389/fimmu.2017.01203
RNA sequencing (RNA-seq) reveals extremely low levels of reticulocyte-derived globin gene transcripts in peripheral blood from horses (Equus caballus) and cattle (Bos taurus) 10.1101/294330
Alveolar macrophage chromatin is modified to orchestrate host response to Mycobacterium bovis infection 10.1101/520098
Genetic diversity and distribution dynamics of multidrug-resistant Mycobacterium tuberculosis isolates in Nepal. 10.1038/s41598-018-34306-w
RNA Sequencing (RNA-Seq) Reveals Extremely Low Levels of Reticulocyte-Derived Globin Gene Transcripts in Peripheral Blood From Horses (Equus caballus) and Cattle (Bos taurus). 10.3389/fgene.2018.00278
A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide. 10.1016/j.tube.2018.08.001
Insight into multidrug-resistant Beijing genotype Mycobacterium tuberculosis isolates in Myanmar. 10.1016/j.ijid.2018.06.009
Comparative 'omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilli. 10.1099/mgen.0.000163
Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe. 10.1099/mic.0.000601
Circulating microRNAs as Potential Biomarkers of Infectious Disease. 10.3389/fimmu.2017.00118
Mycobacterium tuberculosis Complex Members Adapted to Wild and Domestic Animals. 10.1007/978-3-319-64371-7_7
The bovine alveolar macrophage DNA methylome is resilient to infection with Mycobacterium bovis 10.1038/s41598-018-37618-z
WQ-3810: A new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis. 10.1016/j.tube.2019.101891
Direct detection of Mycobacterium tuberculosis in clinical samples by a dry methyl green loop-mediated isothermal amplification (LAMP) method. 10.1016/j.tube.2019.05.004
Identification of microRNAs in bovine faeces and their potential as biomarkers of Johne’s Disease 10.1038/s41598-020-62843-w
Updated functional annotation of the Mycobacterium bovis AF2122/97 reference genome 10.1099/acmi.0.000129
Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria 10.1101/2020.08.25.266668
Mycobacterium bovis genomics reveals transmission of infection between cattle and deer in Ireland 10.1099/mgen.0.000388
Mycobacterial para-Hydroxybenzoic Acid-Derivatives (pHBADs) and Related Structures Induce Macrophage Innate Memory 10.1021/acschembio.0c00378
Phylodynamic analysis of an emergent Mycobacterium bovis outbreak in an area with no previously known wildlife infections 10.1101/2020.11.12.379297
Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference. 10.1371/journal.ppat.1009061
Development of a loop-mediated isothermal amplification (LAMP) method for specific detection of Mycobacterium bovis 10.1371/journal.pntd.0008996
Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21. 10.1016/j.celrep.2019.12.015
The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG 10.3390/ijms22062938
Roland Brosch
Brosch Roland
ORCID: 0000-0003-2587-3863
Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity. 10.1016/j.chom.2015.05.017
Insights on the emergence of Mycobacterium tuberculosis from the analysis of Mycobacterium kansasii 10.1093/gbe/evv035
Mycobacterial Pathogenomics and Evolution. 10.1128/microbiolspec.MGM2-0025-2013
Release of mycobacterial antigens 10.1111/imr.12251
Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice 10.1128/IAI.02032-14
Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083
Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations 10.1038/srep15443
ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection 10.1016/j.tube.2015.02.019
Developing whole mycobacteria cell vaccines for tuberculosis: Workshop proceedings, Max Planck Institute for Infection Biology, Berlin, Germany, July 9, 2014 10.1016/j.vaccine.2015.03.056
Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650
Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans | Les bacilles de la tuberculose bovine - Une évolution aux dépens de la transmissibilité chez l'homme 10.1051/medsci/20153102003
Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection 10.1371/journal.ppat.1003928
Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development 10.2217/fmb.14.70
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator 10.1073/pnas.1406693111
Bacillus calmette-guérin strain differences have an impact on clinical outcome in bladder cancer immunotherapy 10.1016/j.eururo.2014.02.061
A Specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies whiB6 as a novel ESX-1 component 10.1128/IAI.01824-14
A glimpse into the past and predictions for the future: The molecular evolution of the tuberculosis agent 10.1111/mmi.12720
TBCAP; Tuberculosis annotation project 10.1016/j.tube.2012.11.013
Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus 10.1111/mmi.12387
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis 10.1038/ng.2517
ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis 10.1111/cmi.12169
Characterization of Mycobacterium orygis 10.3201/eid1903.121005
The ESX-5 Associated eccB5-eccC5 Locus Is Essential for Mycobacterium tuberculosis Viability 10.1371/journal.pone.0052059
Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion-encoded PE-PPE proteins predicts vaccine potential 10.1016/j.chom.2012.03.003
Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death 10.1371/journal.ppat.1002507
Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh 10.1371/journal.pone.0040545
Molecular epidemiology of tuberculosis in rural Matlab, Bangladesh 10.5588/ijtld.11.0426
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria 10.1111/j.1462-5822.2012.01799.x
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells 10.4161/auto.20881
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation 10.1111/j.1365-2958.2012.08001.x
Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies 10.3201/eid1804.110888
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis 10.1002/eji.201141548
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways 10.1074/jbc.M111.223610
Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants 10.1111/j.1462-5822.2010.01565.x
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG 1on virulence of Mycobacterium tuberculosis 10.1093/infdis/jiq089
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237 10.1016/j.tube.2010.12.007
Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring 10.1016/j.ejmech.2010.09.048
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling 10.1371/journal.ppat.1001100
Entrapment of intracytosolic bacteria by septin cage-like structures 10.1016/j.chom.2010.10.009
Systematic genetic nomenclature for type VII secretion systems 10.1371/journal.ppat.1000507
Pathogenomics of mycobacteria 10.1159/000235772
Pathogenicity in the tubercle bacillus: Molecular and evolutionary determinants 10.1002/bies.200800191
Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus 10.1371/journal.pone.0005660
Myths and misconceptions: The origin and evolution of Mycobacterium tuberculosis 10.1038/nrmicro2165
Mycobacterial PE, PPE and ESX clusters: Novel insights into the secretion of these most unusual protein families 10.1111/j.1365-2958.2009.06784.x
High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors 10.1371/journal.ppat.1000645
ESX/type VII secretion systems and their role in host-pathogen interaction 10.1016/j.mib.2008.11.003
Benzothiazinones Kill Mycobacterium tuberculosis by blocking Arabinan synthesis 10.1126/science.1171583
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis 10.1101/gr.075069.107
Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism 10.1099/mic.0.2008/022269-0
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033
BCG: Molecular history and new perspectives | Le BCG: Histoire moléculaire et nouvelles perspectives RMR-06-2008-25-00-01761-8425-101019-200806495
Genome plasticity of BCG and impact on vaccine efficacy 10.1073/pnas.0700869104
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 10.1128/JB.00469-07
Pathogenomics: Insights into Tuberculosis and Related Mycobacterial Diseases 10.1002/352760801X.ch10
Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis 10.1093/molbev/msj120
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/IAI.74.1.88-98.2006
Contribution of mycobacterial genomics to the development of innovative strategies against tuberculosis | Apports de la génomique des mycobactéries a la définition de nouvelles stratégies thérapeutiques et vaccinales anti-tuberculeuses 10.1016/S1773-035X(06)80148-6
"A re-evaluation of M. prototuberculosis": Continuing the debate 10.1371/journal.ppat.0020095
Tuberculosis: From genome to vaccine 10.1586/14760584.4.4.541
Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against Oxidative Stress 10.1074/jbc.M503076200
Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: The contribution of endogenous mycolactone toxin 10.1111/j.1462-5822.2005.00546.x
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200
Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans 10.1128/JB.187.5.1668-1676.2005
Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis 10.1371/journal.ppat.0010005
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans 10.1073/pnas.0305877101
Genotypic Analysis of Mycobacterium tuberculosis in Bangladesh and Prevalence of the Beijing Strain 10.1128/JCM.42.2.674-682.2004
ESAT-6 proteins: Protective antigens and virulence factors? 10.1016/j.tim.2004.09.007
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468
Cell Envelope Protein PPE68 Contributes to Mycobacterium tuberculosis RD1 Immunogenicity Independently of A 10-Kilodalton Culture Filtrate Protein and ESAT-6 10.1128/IAI.72.4.2170-2176.2004
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/nm859
Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex? [3] (multiple letters) 10.1128/JCM.41.3.1345-1348.2003
Royal society of tropical medicine and hygiene meeting at Manson house, London, 18 January 2001: Pathogen genomes and human health. Mycobacterial genomics 10.1016/S0035-9203(02)90222-1
Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysis 10.1128/JCM.40.7.2339-2345.2002
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant 10.1128/IAI.70.10.5568-5578.2002
A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299
The evolution of mycobacterial pathogenicity: Clues from comparative genomics 10.1016/S0966-842X(01)02131-X
Genomics of Mycobacterium bovis 10.1054/tube.2000.0269
Tools for the population genomics of the tubercle bacilli 10.1101/gr.169200
Comparative genomics of the leprosy and tubercle bacilli 10.1016/S0923-2508(00)00117-0
Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays 10.1046/j.1365-2958.1999.01383.x
Analysis of the proteome of Mycobacterium tuberculosis in silico 10.1054/tuld.1999.0220
The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes 10.1046/j.1365-2958.1998.01124.x
Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence 10.1038/31159
Genomic fingerprinting of 80 strains from the WHO multicenter international typing study of Listeria monocytogenes via pulsed-field gel electrophoresis (PFGE) 10.1016/S0168-1605(96)01147-6
Characterization of Listeria strains isolated from soft cheese 10.1016/0168-1605(93)90220-B
Listeriosis outbreak in France in 1992. Microbial data | Epidémie de listériose en France en 1992 aspects microbiologiques 10.1016/S0399-077X(05)81214-4
Use of pulsed field gel electrophoresis to compare large DNA-restriction fragments of Listeria monocytogenes strains belonging to serogroups 1/2 and 3 10.1016/0168-1605(91)90121-5
Subtyping of Listeria monocytogenes serovar 4b by use of low-frequency-cleavage restriction endonucleases and pulsed-field gel electrophoresis 10.1016/0923-2508(91)90080-T
Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions 10.1038/srep17078
Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis 10.1038/srep16918
Drug-resistant tuberculosis in the European Union: opportunities and challenges for control. 10.1016/j.tube.2010.03.008
The BCG Strain Pool: Diversity Matters. 10.1038/mt.2016.18
Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications. 10.1186/s12864-016-2448-1
Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access. 10.1111/cmi.12622
Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria 10.1073/pnas.1604921113
Comparative Genomics and Evolution of Mycobacterium bovis BCG 10.1128/9781555817657.ch10
The Mycobacteria: a Postgenomic View 10.1128/9781555815530.ch3
Genomics ofMycobacterium Tuberculosis and Mycobacterium Leprae 10.1002/9781444311433.ch5
Genomics of the Mycobacterium tuberculosis complex and Mycobacterium leprae 10.1002/047001153x.g205204
ESX secretion systems: mycobacterial evolution to counter host immunity 10.1038/nrmicro.2016.131
Resistance to thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384 10.1128/aac.02509-16
ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis. 10.1111/cmi.12726
Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis 10.1038/mi.2016.140
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection 10.1016/j.celrep.2017.02.057
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis 10.1371/journal.ppat.1006399
Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells 10.1038/s41598-017-05878-w
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101
Evolution of virulence in the Mycobacterium tuberculosis complex 10.1016/j.mib.2017.11.021
The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis 10.3389/fmicb.2017.02284
Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis 10.1038/s41564-017-0090-6
Discovery of the type VII ESX-1 secretion needle? 10.1111/mmi.13579
Identification of genes required forMycobacterium abscessusgrowth in vivo with a prominent role of the ESX-4 locus 10.1073/pnas.1713195115
Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions 10.1073/pnas.1620133114
Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation 10.1371/journal.ppat.1006752
The Biology and Epidemiology of Mycobacterium canettii 10.1007/978-3-319-64371-7_2
Targeting Type VII/ESX Secretion Systems for Development of Novel Antimycobacterial Drugs 10.2174/1381612819666131118170717
Taxonomic Diversity of Pseudomonads Revealed by Computer-interpretation of Ribotyping Data 10.1016/s0723-2020(96)80026-9
Comparative genomics of the mycobacteria 10.1016/s1438-4221(00)80083-1
Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens 10.3791/50116
Type VII Secretion Systems in Gram-Positive Bacteria 10.1007/82_2015_5015
Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: ‘Aethiops vetus’ 10.1099/mgen.0.000063
Leprosy in red squirrels 10.1126/science.aal0145
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection 10.1371/journal.ppat.1005770
pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence 10.1038/nmicrobiol.2015.19
A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence ofMycobacterium marinumin multiple hosts 10.1111/cmi.12606
The PE and PPE Protein Families of Mycobacterium tuberculosis 10.1002/9783527611614.ch7
Influence of ESAT-6 Secretion System 1 (RD1) of Mycobacterium tuberculosis on the Interaction between Mycobacteria and the Host Immune System 10.4049/jimmunol.174.6.3570
Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125
ESAT-6–dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo 10.1172/jci84978
Cutting-edge science and the future of tuberculosis control 10.2471/blt.06.035386
ESAT-6 and the Mycobacterial ESX Secretion Systems 10.1128/9781555815783.ch13
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection 10.1371/journal.ppat.1007139
Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity 10.1093/gbe/evy145
New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach 10.1016/j.jprot.2018.09.013
Update on the virulence factors of the obligate pathogen Mycobacterium tuberculosis and related tuberculosis-causing mycobacteria 10.1016/j.meegid.2018.12.013
Shared Pathogenomic Patterns Characterize a New Phylotype, Revealing Transition toward Host-Adaptation Long before Speciation of Mycobacterium tuberculosis 10.1093/gbe/evz162
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis. 10.1021/acsnano.8b07902
Mycobacterial virulence: impact on immunogenicity and vaccine research 10.12688/f1000research.20572.1
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages 10.1038/s41467-020-14508-5
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis 10.1038/s41598-020-58967-8
ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins 10.1128/microbiolspec.psib-0029-2019
ESX-4, un système de sécrétion mycobactérien ancestral, essentiel pour la croissance de Mycobacterium abscessus dans les phagocytes environnementaux et humains 10.1051/medsci/2018196
Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages 10.1371/journal.ppat.1008069
A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies 10.1126/sciadv.aaz1767
Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential 10.1016/j.ebiom.2020.102761
Mucosal delivery of ESX-1–expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes 10.1073/pnas.2003235117
Le BCG : histoire moléculaire et nouvelles perspectives 10.1016/s0761-8425(08)56032-3
Breaching the phagosome, the case of the tuberculosis agent 10.1111/cmi.13344
Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection 10.7554/elife.55692
IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo 10.1128/mSphere.00153-21
ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains 10.1128/mBio.00965-21
Evolution of Mycobacterium tuberculosis : New Insights into Pathogenicity and Drug Resistance 10.1128/microbiolspec.tbtb2-0020-2016
Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors 10.3389/fcimb.2020.00420
Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli 10.1038/s41564-021-00938-4
Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran