Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research
Chen Zhang Yerlan Idelbayev Nicholas Roberts Yiwen Tao Yashwanth Nannapaneni Brendan M. Duggan Jie Min Eugene C. Lin Erik C. Gerwick Garrison W. Cottrell William H. Gerwick
Brendan Duggan
Duggan Brendan / Brendan M. Duggan
ORCID: 0000-0002-7034-8374
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Ultra-high resolution band-selective HSQC for nanomole-scale identification of chlorine-substituted13C in natural products drug discovery 10.1002/mrc.4415
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Contribution of increased length and intact capping sequences to the conformational preference for helix in a 31-residue peptide from the C terminus of myohemerythrin 10.1021/bi970038x
1 H and 13 C NMR Relaxation Studies of Molecular Dynamics of the Thyroid Hormones Thyroxine, 3,5,3‘-Triiodothyronine, and 3,5-Diiodothyronine † 10.1021/jm960231+
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus 10.1038/ja.2013.99
Mollenynes B-E from the Marine Sponge Spirastrella mollis. Band-Selective Heteronuclear Single Quantum Coherence for Discrimination of Bromo-Chloro Regioisomerism in Natural Products 10.1021/jacs.5b07858
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria 10.1021/acs.jnatprod.5b00301
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-017-13923-x
Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules 10.1073/pnas.1315492110
Messenger RNAs under differential translational control in Ki-ras-transformed cells 10.1158/1541-7786.MCR-04-0187
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Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides 10.1038/nmicrobiol.2016.197
MS/MS networking guided analysis of molecule and gene cluster families 10.1073/pnas.1303471110
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Interkingdom metabolic transformations captured by microbial imaging mass spectrometry 10.1073/pnas.1206855109
Identification of a 3-alkylpyridinium compound from the red sea sponge Amphimedon chloros with in vitro inhibitory activity against the West Nile Virus NS3 protease 10.3390/molecules23061472
Toward Expanded Diversity of Host–Guest Interactions via Synthesis and Characterization of Cyclodextrin Derivatives 10.1007/s10953-018-0769-1
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Editorial to the Special Issue—“Technology for Natural Products Research” 10.3390/molecules25020327
The Pierced Lasso Topology Leptin has a Bolt on Dynamic Domain Composed by the Disordered Loops I and III 10.1016/j.jmb.2020.01.035
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-020-60108-0
Commensal Oral Rothia mucilaginosa Produces Enterobactin, a Metal-Chelating Siderophore 10.1128/mSystems.00161-20
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides 10.1038/nmicrobiol.2017.10
Experimental characterization of the association of β-cyclodextrin and eight novel cyclodextrin derivatives with two guest compounds 10.1007/s10822-020-00350-w
A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products 10.1021/jacs.9b13786
Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties 10.1021/acschembio.9b00992
Searching for Small Molecules with an Atomic Sort 10.1002/anie.201911862
Searching for Small Molecules with an Atomic Sort 10.1002/anie.202000826
Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for α7 nAChRs 10.1021/acs.jmedchem.9b01467
Chen Zhang
Zhang Chen
ORCID: 0000-0003-4805-0392
Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata 10.3390/md15040121
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-017-13923-x
Dual-Functionalized Theranostic Nanocarriers 10.1021/acsami.6b02761
Synthesis of nano-bowls with a Janus template 10.1039/c4nr05153j
Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing 10.1039/c6nr02445a
Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta 10.1021/acs.joc.5b01264
Designing hollow nano gold golf balls 10.1021/am502519x
Carboxylated nanodiamonds inhibit γ-irradiation damage of human red blood cells 10.1039/c5nr06789h
Energetically biased DNA motor containing a thermodynamically stable partial strand displacement state 10.1021/la503711g
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The Samholides, Swinholide Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp. 10.1021/acs.joc.8b00028
Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, Derbesia sp., Using MS/MS-Based Molecular Networking 10.1021/acs.jnatprod.9b01019
A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products 10.1021/jacs.9b13786
Author Correction: Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-020-60108-0
Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A 10.1021/acs.jnatprod.0c01317
William Gerwick
Gerwick William
ORCID: 0000-0003-1403-4458
Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata 10.3390/md15040121
Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group 10.3390/md16050163
Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease 10.3390/molecules23061472
MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria 10.3390/md16120505
Integrated Genomic and Metabolomic Approach to the Discovery of Potential Anti-Quorum Sensing Natural Products from Microbes Associated with Marine Samples from Singapore 10.3390/md17010072
Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke 10.3390/md18070374
A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria 10.3390/md19010020
Kalkitoxin Reduces Osteoclast Formation and Resorption and Protects against Inflammatory Bone Loss 10.3390/ijms22052303
Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity 10.1021/acs.jmedchem.7b00671
5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34 10.3390/md15080260
The Face of a Molecule 10.1021/acs.jnatprod.7b00624
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-017-13923-x
A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit 10.1021/acschembio.7b00746
Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group 10.1021/acs.jnatprod.7b00917
Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp. 10.1021/acs.joc.8b00028
Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β 10.1021/acschemneuro.7b00527
Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module 10.1021/acschembio.8b00252
Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta 10.1021/acschembio.8b00910
Structural Basis of Polyketide Synthase O-Methylation 10.1021/acschembio.8b00687
Dragocins A−D, Structurally Intriguing Cytotoxic Metabolites from a Panamanian Marine Cyanobacterium 10.1021/acs.orglett.8b03712
Marine natural products as potential anti-tubercular agents 10.1016/j.ejmech.2019.01.026
Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp. 10.1021/acs.orglett.8b04050
Nature's Combinatorial Biosynthesis Produces Vatiamides A–F 10.1002/anie.201902571
Nature's Combinatorial Biosynthesis Produces Vatiamides A–F 10.1002/ange.201902571
Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.9b00549
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain 10.1021/acs.jmedchem.9b00294
Commensal oralRothia mucilaginosaproduces enterobactin – a metal chelating siderophore 10.1101/2020.02.20.956391
Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity 10.3390/molecules25071604
Commensal Oral Rothia mucilaginosa Produces Enterobactin, a Metal-Chelating Siderophore 10.1128/mSystems.00161-20
Correction to “Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp.” 10.1021/acs.orglett.0c02252
The Chemistry, Biochemistry and Pharmacology of Marine Natural Products from Leptolyngbya, a Chemically Endowed Genus of Cyanobacteria 10.3390/md18100508
Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2 10.1021/acs.jnatprod.0c00968
Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A 10.1021/acs.jnatprod.0c01317
Cyanobacteria-shrimp colonies in the Mariana Islands 10.1007/s10452-021-09837-6
Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium 10.1021/acs.jnatprod.0c01383
SIRT1 Activation Enhancing 8,3′-Neolignans from the Twigs of Corylopsis coreana Uyeki 10.3390/plants10081684
First Total Synthesis and Structure–Activity Relationship of Iheyamide A, an Antitrypanosomal Linear Peptide Isolated from a Dapis sp. Marine Cyanobacterium 10.1021/acs.jnatprod.1c00792
Garrison Cottrell
Cottrell Garrison
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Author Correction: Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research (Scientific Reports, (2017), 7, 1, (14243), 10.1038/s41598-017-13923-x) 10.1038/s41598-020-60108-0
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A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products 10.1021/jacs.9b13786
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Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, Derbesia sp., Using MS/MS-Based Molecular Networking 10.1021/acs.jnatprod.9b01019
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Research Note: A Hybrid Model of the Intentional Behavior of the Dog 10.1080/09540098908915645
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-017-13923-x
Belief tree search for active object recognition 10.1109/IROS.2017.8206290
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Eugene Lin
Lin Eugene / Eugene C. Lin
ORCID: 0000-0002-9780-4982
Role of the cholesterol hydroxyl group in the chemical exchange saturation transfer signal at −1.6 ppm 10.1002/nbm.4356
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Author Correction: Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research (Scientific Reports, (2017), 7, 1, (14243), 10.1038/s41598-017-13923-x) 10.1038/s41598-020-60108-0
Microscopy ambient ionization top-down mass spectrometry reveals developmental patterning 10.1073/pnas.1310618110
Relayed nuclear Overhauser enhancement sensitivity to membrane Cho phospholipids 10.1002/mrm.28258
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-017-13923-x
Chemical exchange rotation transfer (CERT) on human brain at 3 Tesla 10.1002/mrm.27365
Structural determination of virus protein U from HIV-1 by NMR in membrane environments 10.1016/j.bbamem.2015.09.008
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Fluorogenic enzyme-responsive micellar nanoparticles 10.1039/c2sc20165h
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Experiments optimized for magic angle spinning and oriented sample solid-state NMR of proteins 10.1021/jp407154h
Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies 10.1021/acsnano.9b07326
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Assignment of the molecular origins of CEST signals at 2 ppm in rat brain 10.1002/mrm.26802
pH Mapping of Skeletal Muscle by Chemical Exchange Saturation Transfer (CEST) Imaging 10.3390/cells9122610
Chemical exchange rotation transfer imaging of phosphocreatine in muscle 10.1002/nbm.4437
Probing metabolic alterations in breast cancer in response to molecular inhibitors with Raman spectroscopy and validated with mass spectrometry 10.1039/d0sc02221g
Sulfo-Fluorous Tagging Strategy for Site-Selective Enzymatic Glycosylation of para-Human Milk Oligosaccharides 10.1021/acscatal.0c04934
Erratum: Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies (ACS Nano (2020) 14: 1 (651−663). DOI: 10.1021/acsnano.9b07326) 10.1021/acsnano.0c09667