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Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis

Phuong Chi Nguyen Delorme, Vincent Benarouche, Anais Martin, Benjamin P. Paudel, Rishi Gnawali, Giri R. Madani, Abdeldjalil Puppo, Remy Landry, Valerie Kremer, Laurent Brodin, Priscille Spilling, Christopher D. Cavalier, Jean-Francois Canaan, Stephane

Scientific reports, 2017-9

https://doi.org/10.1038/s41598-017-11843-4

Vincent Delorme

Delorme Vincent

ORCID: 0000-0001-5235-7069

Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent. 10.1016/j.bmc.2020.115797

Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. 10.1016/j.stemcr.2019.10.002

Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis. 10.1016/j.bioorg.2018.08.025

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains. 10.3389/fcimb.2018.00114

Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-018-25177-2

Mycobacterium tuberculosis Infection and Innate Responses in a New Model of Lung Alveolar Macrophages. 10.3389/fimmu.2018.00438

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. 10.1038/s41598-017-11843-4

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 10.1016/j.celrep.2017.08.101

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-017-05453-3

Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis. 10.1128/aac.02637-16

Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. 10.1021/acschembio.7b00091

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. 10.1126/science.aag1006

High-Content Screening of Raw Actinomycete Extracts for the Identification of Antituberculosis Activities. 10.1177/1087057116675887

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. 10.1039/c5ob02630j

Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays. 10.1007/978-1-4939-2450-9_24

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1. 10.1021/cb5007163

Supported inhibitor for fishing lipases in complex biological media and mass spectrometry identification. 10.1016/j.biochi.2014.07.015

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Phenotypic Screening for Drug Discovery in Tuberculosis https://doi.org/10.1039/9781839160721-00198

Jean-François Cavalier

Cavalier Jean-François / J.-F. Cavalier

ORCID: 0000-0003-0864-8314

http://tuberculosis-lbp.wixsite.com/tuberculosis-lbpteam/people

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Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones 10.1016/j.ejmech.2012.10.040

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Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4

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Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025

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Biochemical and Structural Characterization of TesA, a Major Thioesterase Required for Outer-Envelope Lipid Biosynthesis in Mycobacterium tuberculosis 10.1016/j.jmb.2018.09.017

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Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria 10.1038/s41598-019-45164-5

Cyclipostins and Cyclophostin analogs are multi-target inhibitors that impair growth of Mycobacterium abscessus. 10.1021/acsinfecdis.9b00172

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Priscille Brodin

Brodin Priscille

ORCID: 0000-0003-0991-7344

Email: priscille.brodin@inserm.fr

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Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.

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Laurent Kremer

Kremer Laurent

ORCID: 0000-0002-6604-4458

https://www.irim.cnrs.fr/index.php/en/researchh/teams/mycobacterial-pathogenesis-and-novel-therapeutic-targets

Mycobacteriophage–antibiotic therapy promotes enhanced clearance of drug-resistant Mycobacterium abscessus 10.1242/dmm.049159

Dissecting erm (41)-Mediated Macrolide-Inducible Resistance in Mycobacterium abscessus 10.1128/AAC.01879-19

Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus 10.1128/AAC.02548-19

Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus 10.1038/s41579-020-0331-1

CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses 10.1016/j.celrep.2019.01.071

Use of the Salmonella MgtR peptide as an antagonist of the Mycobacterium MgtC virulence factor 10.2217/FMB.15.134

Recent advances and therapeutic journey of coumarins: current status and perspectives 10.1007/S00044-015-1350-8

Mycobacterium tuberculosis Maltosyltransferase GlgE, a Genetically Validated Antituberculosis Target, Is Negatively Regulated by Ser/Thr Phosphorylation 10.1074/JBC.M112.398503

MmPPOX Inhibits Mycobacterium tuberculosis Lipolytic Enzymes Belonging to the Hormone-Sensitive Lipase Family and Alters Mycobacterial Growth 10.1371/JOURNAL.PONE.0046493

The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation 10.1016/J.BBRC.2014.03.074

Detection of Mycobacterium tuberculosis in paucibacillary sputum: performances of the Xpert MTB/RIF ultra compared to the Xpert MTB/RIF, and IS6110 PCR 10.1016/J.DIAGMICROBIO.2019.02.008

Design, synthesis, anti-mycobacterial and cytotoxic evaluation of C-4 functionalized 1,8-naphthalimide-heterocyclic hydrazide conjugates 10.1111/CBDD.13503

Lsr2 Is an Important Determinant of Intracellular Growth and Virulence in Mycobacterium abscessus 10.3389/FMICB.2019.00905

1H-Benzo[d]Imidazole Derivatives Affect MmpL3 in Mycobacterium tuberculosis 10.1128/AAC.00441-19

Characterization of a mycobacterial cellulase and its impact on biofilm- and drug-induced cellulose production 10.1093/GLYCOB/CWX014

Attenuation of Mycobacterium species through direct and macrophage mediated pathway by unsymmetrical diaryl urea 10.1016/J.EJMECH.2016.09.083

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/S41598-017-11843-4

Binding of NADP(+) triggers an open-to-closed transition in a mycobacterial FabG beta-ketoacyl-ACP reductase 10.1042/BCJ20161052

Acid-Fast Positive and Acid-Fast Negative Mycobacterium tuberculosis: The Koch Paradox 10.1128/MICROBIOLSPEC.TBTB2-0003-2015

Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases 10.1016/J.IJANTIMICAG.2017.12.001

Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms 10.1371/JOURNAL.PONE.0196120

A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatis 10.1111/MMI.12992

Increased Phagocytosis of Mycobacterium marinum Mutants Defective in Lipooligosaccharide Production 10.1074/JBC.M113.525550

Dry-Powder Inhaler Formulation of Rifampicin: An Improved Targeted Delivery System for Alveolar Tuberculosis 10.1089/JAMP.2017.1379

The Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Synthase III Activity Is Inhibited by Phosphorylation on a Single Threonine Residue 10.1074/JBC.M806537200

Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis 10.1074/JBC.M110.105189

TheMycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: Mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c 10.1002/PMIC.200700442

Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis 10.1111/J.1365-2958.2010.07446.X

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis 10.1038/NCHEMBIO.1277

Expression of OmpATb is dependent on small membrane proteins in Mycobacterium bovis BCG 10.1016/J.TUBE.2011.06.008

Mycobacterial lipomannan induces granuloma macrophage fusion via a TLR2-dependent, ADAM9- and beta(1) integrin-mediated pathway 10.4049/JIMMUNOL.178.5.3161

Phosphorylation of KasB Regulates Virulence and Acid-Fastness in Mycobacterium tuberculosis 10.1371/JOURNAL.PPAT.1004115

LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum 10.1074/JBC.M507500200

Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking 10.1371/JOURNAL.PPAT.1005986

Azide-alkyne cycloaddition en route to 4-aminoquinoline-ferrocenylchalcone conjugates: synthesis and anti-TB evaluation 10.4155/FMC-2017-0098

Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384 10.1128/AAC.02509-16

Microwave-Assisted Highly Efficient Route to 4-Aminoquinoline-Phthalimide Conjugates: Synthesis and Anti-Tubercular Evaluation 10.1002/SLCT.201702220

The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium 10.1038/SREP42692

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections 10.1021/ACS.JMEDCHEM.7B00582

MmpL8(MAB) controls Mycobacterium abscessus virulence and production of a previously unknown glycolipid family 10.1073/PNAS.1812984115

Glycopeptidolipids, a Double-Edged Sword of the Mycobacterium abscessus Complex 10.3389/FMICB.2018.01145

The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages 10.1098/RSOB.160185

Synthesis and Antimycobacterial Evaluation of Piperazyl-alkyl-Ether Linked 7-Chloroquinoline-Chalcone/Ferrocenyl Chalcone Conjugates 10.1002/SLCT.201801453

Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent 10.1073/PNAS.1605477113

Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport 10.3389/FCIMB.2017.00388

Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members 10.1111/MMI.13283

MAB_3551c encodes the primary triacylglycerol synthase involved in lipid accumulation in Mycobacterium abscessus 10.1111/MMI.13482

Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish 10.1128/AAC.01225-17

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus 10.1073/PNAS.1713195115

Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers 10.1039/C8RA10532D

Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages 10.1128/IAI.00394-18

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus 10.1111/MMI.13406

Alkylated/aminated nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates: Synthesis and anti-mycobacterial evaluation 10.1016/J.BMCL.2018.03.021

Optimized Lysis-Extraction Method Combined With IS6110-Amplification for Detection of Mycobacterium tuberculosis in Paucibacillary Sputum Specimens 10.3389/FMICB.2018.02224

Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus 10.3389/FMICB.2018.00649

A Simple and Rapid Gene Disruption Strategy in Mycobacterium abscessus: On the Design and Application of Glycopeptidolipid Mutants 10.3389/FCIMB.2018.00069

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts 10.1111/CMI.12606

1H-1,2,3-triazole-tethered uracil-ferrocene and uracil-ferrocenylchalcone conjugates: Synthesis and antitubercular evaluation 10.1111/CBDD.12908

B cells response directed against Cut4 and CFP21 lipolytic enzymes in active and latent tuberculosis infections 10.1371/JOURNAL.PONE.0196470

Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo 10.1074/JBC.RA117.000760

Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis beta-ketoacyl-acyl carrier protein reductase MabA 10.1107/S2059798318002917

Identification of KasA as the cellular target of an anti-tubercular scaffold 10.1038/NCOMMS12581

The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments 10.1111/MMI.13675

Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus 10.1128/AAC.01316-18

Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens 10.1007/S00109-001-0307-1

The Fatty Acid Biosynthesis Enzyme Fabl Plays a Key Role in the Development of Liver-Stage Malarial Parasites 10.1016/J.CHOM.2008.11.001

TLR2-dependent eosinophil interactions with mycobacteria: role of alpha-defensins 10.1182/BLOOD-2008-07-166595

CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan 10.1016/J.IMLET.2012.02.011

Severe inhibition of lipooligosaccharide synthesis induces TLR2-dependent elimination of Mycobacterium marinum from THP1-derived macrophages 10.1186/S12934-017-0829-Z

Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis 10.1074/JBC.M000569200

Efficient homologous recombination in fast-growing and slow-growing mycobacteria. 10.1128/JB.178.11.3091-3098.1996

Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids 10.1016/J.CHEMBIOL.2006.01.005

ESX-4, a system of ancestral mycobacterial secretion, essential for the growth of Mycobacterium abscessus in environmental and human phagocytes 10.1051/MEDSCI/2018196

Synthesis and in vitro anti-tubercular evaluation of 1,2,3-triazole tethered beta-lactam-ferrocene and beta-lactam-ferrocenylchalcone chimeric scaffolds 10.1039/C2DT30514C

Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism 10.1128/IAI.73.10.7064-7068.2005

Exposure of Mycobacteria to Cell Wall-inhibitory Drugs Decreases Production of Arabinoglycerolipid Related to Mycolyl-arabinogalactan-peptidoglycan Metabolism 10.1074/JBC.M111.327387

Temperature-dependent Regulation of Mycolic Acid Cyclopropanation in Saprophytic Mycobacteria ROLE OF THE MYCOBACTERIUM SMEGMATIS 1351 GENE (MSMEG_1351) IN CIS-CYCLOPROPANATION OF alpha-MYCOLATES 10.1074/JBC.M110.125724

Cyrhetrenyl and ferrocenyl 1,3,4-thiadiazole derivatives: Synthesis, characterization, crystal structures and in vitro antitubercular activity 10.1016/J.INOCHE.2015.03.008

The Molecular Genetics of Mycolic Acid Biosynthesis 10.1128/MICROBIOLSPEC.MGM2-0003-2013

EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR 10.1042/BJ20071384

Ineffective cellular immune response associated with T-cell apoptosis in susceptible Mycobacterium bovis BCG-infected mice 10.1128/IAI.68.7.4264-4273.2000

The Diverse Cellular and Animal Models to Decipher the Physiopathological Traits of Mycobacterium abscessus Infection 10.3389/FCIMB.2017.00100

Altered NADH/NAD+ Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria 10.1128/AAC.49.2.708-720.2005

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis 10.1042/0264-6021:3630437

Mycobacterium bovis Bacillus Calmette Guerin infection prevents apoptosis of resting human monocytes 10.1002/EJI.1830270945

Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages 10.1016/J.FEBSLET.2008.01.007

Mycobacterium tuberculosis Lipomannan Induces Apoptosis and Interleukin-12 Production in Macrophages 10.1128/IAI.72.4.2067-2074.2004

Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives 10.1016/J.BMCL.2010.12.084

beta-Lactamase inhibition by avibactam in Mycobacterium abscessus 10.1093/JAC/DKU510

Mycobacteriennes strings. A new means of exhausting in the immune system? 10.1051/MEDSCI/20143005008

Enzymatic Hydrolysis of Trehalose Dimycolate Releases Free Mycolic Acids during Mycobacterial Growth in Biofilms 10.1074/JBC.M110.112813

pETPhos: A customized expression vector designed for further characterization of Ser/Thr/Tyr protein kinases and their substrates 10.1016/J.PLASMID.2008.05.002

Overexpression of the KdpF Membrane Peptide in Mycobacterium bovis BCG Results in Reduced Intramacrophage Growth and Altered Cording Morphology 10.1371/JOURNAL.PONE.0060379

Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c) 10.1107/S0907444903020456

Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis 10.1016/J.PEP.2007.11.012

Galactan biosynthesis in Mycobacterium tuberculosis - Identification of a bifunctional UDP-galactofuranosyltransferase 10.1074/JBC.M102022200

The Mycobacterium tuberculosis GroEL1 chaperone is a substrate of Ser/Thr protein kinases 10.1128/JB.01569-08

Identification by surface plasmon resonance of the mycobacterial lipomannan and lipoarabinomannan domains involved in binding to CD14 and LPS-binding protein 10.1016/J.FEBSLET.2007.02.056

Biochemical Characterization of Acyl Carrier Protein (AcpM) and Malonyl-CoA:AcpM Transacylase (mtFabD), Two Major Components of Mycobacterium tuberculosis Fatty Acid Synthase II 10.1074/JBC.M103687200

MgtC as a Host-Induced Factor and Vaccine Candidate against Mycobacterium abscessus Infection 10.1128/IAI.00359-16

Mycobacterium bovis BCG Producing Interleukin-18 Increases Antigen-Specific Gamma Interferon Production in Mice 10.1128/IAI.70.12.6549-6557.2002

Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria 10.1111/J.1365-2958.2008.06274.X

From the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell division 10.1074/JBC.M802615200

An improved method to unravel phosphoacceptors in Ser/Thr protein kinase-phosphorylated substrates 10.1002/PMIC.201000316

Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice 10.1073/PNAS.0608654104

7-Chloroquinoline-isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation 10.1111/CBDD.12273

Lipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-alpha and IL-8 secretion by a CD14-Toll-like receptor 2-dependent mechanism 10.4049/JIMMUNOL.171.4.2014

In Vivo Assessment of Drug Efficacy against Mycobacterium abscessus Using the Embryonic Zebrafish Test System 10.1128/AAC.00142-14

The Methyl-Branched Fortifications of Mycobacterium tuberculosis 10.1016/S1074-5521(02)00142-4

Immunostimulatory effect of IL-18-encoding plasmid in DNA vaccination against murine Schistosoma mansoni infection 10.1016/S0264-410X(00)00363-7

Organometallic tosyl hydrazones: Synthesis, characterization, crystal structures and in vitro evaluation for anti-Mycobacterium tuberculosis and antiproliferative activities 10.1016/J.POLY.2017.04.031

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos 10.3791/53130

The M. tuberculosis antigen 85 complex and mycolyltransferase activity 10.1046/J.1472-765X.2002.01091.X

Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii - Novel structural features and apoptosis-inducing properties 10.1074/JBC.M305427200

Synthesis, characterization and in vitro anti-Trypanosoma cruzi and anti-Mycobacterium tuberculosis evaluations of cyrhetrenyl and ferrocenyl thiosemicarbazones 10.1016/J.JORGANCHEM.2013.12.049

Mycobacterium lutetiense sp. nov., Mycobacterium montmartrense sp. nov. and Mycobacterium arcueilense sp. nov., members of a novel group of non-pigmented rapidly growing mycobacteria recovered from a water distribution system 10.1099/IJSEM.0.001253

Design, synthesis and docking studies of some novel (R)-2-(4 '-chlorophenyl)-3-(4 '-nitrophenyl)-1,2,3,5-tetrahydrobenzo[4,5] imidazo [1,2-c]pyrimidin-4-ol derivatives as antitubercular agents 10.1016/J.EJMECH.2014.06.019

A new series of mycobacterial expression vectors for the development of live recombinant vaccines 10.1016/0378-1119(96)00239-9

Structural Analysis of an Unusual Bioactive N-Acylated Lipo-Oligosaccharide LOS-IV in Mycobacterium marinum 10.1021/JA105807S

Natural and Synthetic Flavonoids as Potent Mycobacterium tuberculosis UGM Inhibitors 10.1002/CHEM.201701812

Phosphorylation of Mycobacterial PcaA Inhibits Mycolic Acid Cyclopropanation 10.1074/JBC.M112.373209

Mycolic acid biosynthesis and enzymic characterization of the β-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis 10.1042/BJ20011628

Mycobacterium marinum Lipooligosaccharides Are Unique Caryophyllose-containing Cell Wall Glycolipids That Inhibit Tumor Necrosis Factor-alpha Secretion in Macrophages 10.1074/JBC.M109.011429

Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria 10.1371/JOURNAL.PONE.0001343

Protein PknE, a novel transmembrane eukaryotic-like serine/threonine kinase from Mycobacterium tuberculosis 10.1016/S0006-291X(03)01476-1

Re-emergence of tuberculosis: strategies and treatment 10.1517/13543784.11.2.153

Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way 10.1111/J.1365-2958.2009.07041.X

Functional Role of the PE Domain and Immunogenicity of the Mycobacterium tuberculosis Triacylglycerol Hydrolase LipY 10.1128/IAI.00410-07

AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain 10.1128/JB.05638-11

Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile 10.1099/00221287-148-10-3145

Lipoarabinomannan: structure and functions of a glycolipid involved in tuberculosis pathogenicity 10.4267/10608/1441

Polysaccharide structural variability in mycobacteria: identification and characterization of phosphorylated mannan and arabinomannan 10.1007/S10719-007-9036-1

Mycobacterium marinum MgtC Plays a Role in Phagocytosis but is Dispensable for Intracellular Multiplication 10.1371/JOURNAL.PONE.0116052

pH-dependent pore-forming activity of OmpATb from Mycobacterium tuberculosis and characterization of the channel by peptidic dissection 10.1111/J.1365-2958.2006.05277.X

Immune Response Induced by Recombinant Mycobacterium bovis BCG Producing the Cholera Toxin B Subunit 10.1128/IAI.71.5.2933-2937.2003

Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis 10.1371/JOURNAL.PONE.0025078

Probing the Mechanism of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Synthase III mt FabH 10.1074/JBC.M413216200

Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia 10.1016/J.IJANTIMICAG.2013.03.007

Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation 10.1016/J.BBRC.2012.11.038

4-Aminoquinoline-beta-Lactam Conjugates: Synthesis, Antimalarial, and Antitubercular Evaluation 10.1111/CBDD.12225

Fatty Acyl Chains of Mycobacterium marinum Lipooligosaccharides 10.1074/JBC.M111.273920

Mercury resistance as a selective marker for recombinant mycobacteria 10.1099/13500872-141-4-1045

Identification of inhibitors targeting Mycobacterium tuberculosis cell wall biosynthesis via dynamic combinatorial chemistry 10.1039/C7CC05251K

GroEL1: A Dedicated Chaperone Involved in Mycolic Acid Biosynthesis during Biofilm Formation in Mycobacteria 10.1016/J.CELL.2005.09.012

Dynamic and Structural Characterization of a Bacterial FHA Protein Reveals a New Autoinhibition Mechanism 10.1016/J.STR.2009.02.012

ANALYSIS OF THE MYCOBACTERIUM-TUBERCULOSIS 85A ANTIGEN PROMOTER REGION 10.1128/JB.177.3.642-653.1995

Structural Determination and Toll-like Receptor 2-dependent Proinflammatory Activity of Dimycolyl-diarabino-glycerol from Mycobacterium marinum 10.1074/JBC.M112.378083

Exposure to a Cutinase-like Serine Esterase Triggers Rapid Lysis of Multiple Mycobacterial Species 10.1074/JBC.M112.419754

Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis 10.3389/FCIMB.2016.00122

Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones 10.1016/J.BMCL.2011.03.082

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues 10.1371/JOURNAL.PONE.0053162

Base-Promoted Expedient Access to Spiroisatins: Synthesis and Antitubercular Evaluation of 1H-1,2,3-Triazole-Tethered Spiroisatin-Ferrocene and Isatin-Ferrocene Conjugates 10.1021/OM4009229

EthA, a Common Activator of Thiocarbamide-Containing Drugs Acting on Different Mycobacterial Targets 10.1128/AAC.01063-06

Current perspectives on the families of glycoside hydrolases of Mycobacterium tuberculosis : their importance and prospects for assigning function to unknowns 10.1093/GLYCOB/CWW099

Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones (vol 21, pg 2866, 2011) 10.1016/J.BMCL.2011.05.011

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid 10.1038/NM1466

A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos 10.1111/J.1365-2958.2011.07618.X

Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae - Presence of unusual components with alpha 1,3-mannopyranose side chains 10.1074/JBC.M204398200

Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis 10.1042/BJ20020107

Toll-Like Receptor 2 (TLR2)-Dependent-Positive and TLR2-Independent-Negative Regulation of Proinflammatory Cytokines by Mycobacterial Lipomannans 10.4049/JIMMUNOL.172.7.4425

Current status and future development of antitubercular chemotherapy 10.1517/13543784.11.8.1033

Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation 10.1073/PNAS.1321390111

Point Mutations within the Fatty Acid Synthase Type II Dehydratase Components HadA or HadC Contribute to Isoxyl Resistance in Mycobacterium tuberculosis 10.1128/AAC.01972-12

The C-Terminal Domain of the Virulence Factor MgtC Is a Divergent ACT Domain 10.1128/JB.01424-12

Azide-alkyne cycloaddition en route towards 1H-1,2,3-triazole-tethered beta-lactam-ferrocene and beta-lactam-ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation 10.1039/C2DT32148C

Inhibition of the beta-Lactamase Bla(Mab) by Avibactam Improves the In Vitro and In Vivo Efficacy of Imipenem against Mycobacterium abscessus 10.1128/AAC.02440-16

Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol 10.1111/J.1365-2958.2005.04717.X

New cyrhetrenyl and ferrocenyl sulfonamides: Synthesis, characterization, X-ray crystallography, theoretical study and anti-Mycobacterium tuberculosis activity 10.1016/J.POLY.2017.06.015

Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis 10.1073/PNAS.0507766103

1H-1,2,3-Triazole-Tethered Isatin-Ferrocene and Isatin-Ferrocenylchalcone Conjugates: Synthesis and in Vitro Antitubercular Evaluation 10.1021/OM301157Z

The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds 10.1016/J.TUBE.2003.12.005

GREEN FLUORESCENT PROTEIN AS A NEW EXPRESSION MARKER IN MYCOBACTERIA 10.1111/J.1365-2958.1995.MMI_17050913.X

Interleukin-18 modulates immune responses induced by HIV-1 Nef DNA prime/protein boost vaccine 10.1016/S0264-410X(00)00157-2

Antimycobacterial Activity and Mechanism of Action of NAS-91 10.1128/AAC.00968-07

The N-Terminal Domain of OmpATb Is Required for Membrane Translocation and Pore-Forming Activity in Mycobacteria 10.1128/JB.00509-07

A Waxy Tale, by Mycobacterium tuberculosis 10.1128/9781555817657.CH19

Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT) 10.1107/S1744309107042455

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis 10.1128/MBIO.00222-13

The Mycobacterium tuberculosis Ser/Thr Kinase Substrate Rv2175c Is a DNA-binding Protein Regulated by Phosphorylation 10.1074/JBC.M109.019653

Antitubercular Activity of Disulfiram, an Antialcoholism Drug, against Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates 10.1128/AAC.06445-11

Looking through zebrafish to better understand the interactions host / pathogen 10.1051/MEDSCI/20153106017

Oleic Acid Biosynthesis in Plasmodium falciparum: Characterization of the Stearoyl-CoA Desaturase and Investigation as a Potential Therapeutic Target 10.1371/JOURNAL.PONE.0006889

Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria 10.1074/JBC.M302435200

The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation 10.1074/JBC.M601691200

Identification of the Mycobacterium marinum Apa antigen O-mannosylation sites reveals important glycosylation variability with the M. tuberculosis Apa homologue 10.1016/J.JPROT.2012.07.017

Mycobacterial lipolytic enzymes: A gold mine for tuberculosis research 10.1016/J.BIOCHI.2012.07.008

The Structure of Mycobacterium tuberculosis MPT51 (FbpC1) Defines a New Family of Non-catalytic α/β Hydrolases 10.1016/J.JMB.2003.11.001

Recombinant Mycobacterium bovis BCG producing IL-18 reduces IL-5 production and bronchoalveolar eosinophilia induced by an allergic reaction 10.1111/J.1398-9995.2005.00826.X

Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response 10.1111/J.1365-2958.2004.04183.X

Conditional Depletion of KasA, a Key Enzyme of Mycolic Acid Biosynthesis, Leads to Mycobacterial Cell Lysis 10.1128/JB.187.22.7596-7606.2005

Acetic Acid, the Active Component of Vinegar, Is an Effective Tuberculocidal Disinfectant 10.1128/MBIO.00013-14

The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development 10.1111/J.1365-2958.2007.05761.X

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Nathalie deboosere

deboosere Nathalie

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A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis 10.1016/j.bmc.2014.10.042

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The ene reaction of 5-allyl-2ε{lunate}-hydroxy-5α-cholestan-3-one: An unusually facile ene reaction 10.1016/S0040-4039(00)95787-3

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Reactions of Chiral Phosphorous Acid Diamides: The Asymmetric Synthesis of Chiral αpha;-Hydroxy Phosphonamides, Phosphonates, and Phosphonic Acids 10.1021/jo00109a025

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The first total synthesis of (±)-cyclophostin and (±)-cyclipostin P: Inhibitors of the serine hydrolases acetyl cholinesterase and hormone sensitive lipase 10.1021/ol200991x

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A Practical and Scalable Synthesis of (S)- and (R)-1-(Dimethoxyphosphoryl)allyl Methyl Carbonates 10.1055/s-0035-1560487

(Benzyloxy)nitromethane: A New Reagent in Bicyclic β-Lactam Synthesis 10.1021/jo00265a054

An expeditious total synthesis of both diastereoisomeric lipid dihydroxytetrahydrofurans from Notheia anomala 10.1021/ol300597u

Stereoselective synthesis of cyclic ethers via the palladium-catalyzed intramolecular addition of alcohols to phosphono allylic carbonates 10.1021/ol900980s

Total Synthesis of rapamycin 10.1002/chem.200801656

Effect of ligand structure on the pathways for iron release from human serum transferrin 10.1021/ic050411m

Efficient synthesis of tyrosine-derived marine sponge metabolites via acylation of amines with a coumarin 10.1021/jo050846r

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Trapping hemiacetals with phosphono substituted palladium π-allyl complexes for the synthesis of substituted cyclic ethers 10.1016/j.tetlet.2015.01.050

Rat hormone sensitive lipase inhibition by cyclipostins and their analogs 10.1016/j.bmc.2015.01.028

The synthesis of 1-hydroxy phosphonates of high enantiomeric excess using sequential asymmetric reactions: Titanium alkoxide-catalyzed P-C bond formation and kinetic resolution 10.1016/S0957-4166(01)00303-2

Palladium catalyzed additions to allylic hydroxy phosphonates: Applications in the enantioselective synthesis of enterolactone and turmerone 10.1080/10426500212246

Approaches to Avermectin Assembly: A Concise Stereospecific Synthesis of the Hexahydrobenzofuran Entity 10.1021/jo00295a032

Intermolecular charge transfer in organic donor-acceptor systems for optical storage applications 10.1117/12.323488

The preparation of acyl phosphonates by the heterogeneous oxidation of 1-hydroxy phosphonates 10.1016/S0040-4039(98)01933-9

Synthesis of non-racemic α-hydroxyphosphonates via asymmetric phospho-aldol reaction 10.1007/128_2014_583

Concise synthesis of 1,3-di-O-substituted tetrahydropyran derivatives as conformationally stable pyranose mimetics 10.1016/j.crci.2010.05.016

Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase 10.1016/j.bmc.2010.01.063

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Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases 10.1021/jm301216x

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Synthesis and biological evaluation of purpurealidin E-derived marine sponge metabolites: Aplysamine-2, Aplyzanzine A, and Suberedamines A and B 10.1021/np300102z

LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling 10.1042/BSR20181953

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Reactions of chiral phosphorus acid diamides: Lewis acid catalyzed addition to imines and oxidation with snc 10.1080/10426509508027375

Chemistry of glucal halohydrins(II): An unusual protecting group effect in the competitive formation of formyl furanosides and methyl glycosides 10.1016/S0008-6215(97)00054-2

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The regio- and stereo-selective epoxidation of alkenes with methyl trioxorhenium and urea-hydrogen peroxide adduct 10.1016/0040-4039(96)00423-6

The enantioselective addition of dialkylphosphites to aldehydes: Catalysis by a lanthanum binaphthoxide complex 10.1016/S0040-4039(00)76517-8

A formal synthesis of the C1-C9 fragment of amphidinolide C employing the tamaru reaction 10.1021/ol100959a

The chemistry of glucal halohydrins: The effect of the halide on epoxide formation 10.1016/S0040-4020(01)81332-6

Synthesis and biological evaluation of a phosphonate analog of the natural acetyl cholinesterase inhibitor cyclophostin 10.1021/jo801453v

Methyl 4-hydroxy-3-[4-methoxy-2-(methoxymethyleneoxy)phenyl]-2-{[4-methoxy-2- (methoxymethyleneoxy)-phenyl]methyl}-5-oxo-2,5-dihydrofuran-2-carboxylate 10.1107/S0108270196011602

An intramolecular N-H⋯Co hydrogen bond and a structure correlation study of the pathway for protonation of the Co(CO)3L^- anion (L = CO, PR3) 10.1016/S0022-328X(00)00377-6

Synthesis of Phostones via the Palladium-Catalyzed Ring Opening of Epoxy Vinyl Phosphonates 10.1021/acs.joc.9b00905

Synthesis of Phosphonomethyl Tetrahydrofurans via the Mori–Tamaru Reaction of Phosphonodienes 10.1021/acs.orglett.0c01080