Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
Pethe, Kevin Bifani, Pablo Jang, Jichan Kang, Sunhee Park, Seijin Ahn, Sujin Jiricek, Jan Jung, Juyoung Jeon, Hee Kyoung Cechetto, Jonathan Christophe, Thierry Lee, Honggun Kempf, Marie Jackson, Mary Lenaerts, Anne J. Ha Pham Jones, Victoria Seo, Min Jung Kim, Young Mi Seo, Mooyoung Seo, Jeong Jea Park, Dongsik Ko, Yoonae Choi, Inhee Kim, Ryangyeo Kim, Se Yeon Lim, SeungBin Yim, Seung-Ae Nam, Jiyoun Kang, Hwankyu Kwon, Haejin Oh, Chun-Taek Cho, Yoojin Jang, Yunhee Kim, Junghwan Chua, Adeline Tan, Bee Huat Nanjundappa, Mahesh B. Rao, Srinivasa P. S. Barnes, Whitney S. Wintjens, Rene Walker, John R. Alonso, Sylvie Lee, Saeyeon Kim, Jungjun Oh, Soohyun Oh, Taegwon Nehrbass, Ulf Han, Sung-Jun No, Zaesung Lee, Jinhwa Brodin, Priscille Cho, Sang-Nae Nam, Kiyean Kim, Jaeseung
Nature medicine, 2013-8
https://doi.org/10.1038/nm.3262
Mary Jackson
Jackson Mary
ORCID: 0000-0002-9212-0258
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Priscille Brodin
Brodin Priscille
ORCID: 0000-0003-0991-7344
Email: priscille.brodin@inserm.fr
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Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4
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Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101
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Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360
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Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902
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Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication 10.1128/jvi.02009-18
A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J
Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls 10.3390/toxins11090516
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Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity. 10.1021/acsinfecdis.9b00277
Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds. 10.1371/journal.pone.0227224
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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g
Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38
Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82
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Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505
Pablo Bifani
Bifani Pablo
ORCID: 0000-0001-9651-6439
Worldwide Occurrence of Beijing/W Strains ofMycobacterium tuberculosis: A Systematic Review 10.3201/eid0808.020002
Identification of a W Variant Outbreak of Mycobacterium tuberculosis via Population-Based Molecular Epidemiology 10.1001/jama.282.24.2321
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Genomic Epidemiology of Lineage 4 Mycobacterium tuberculosis Subpopulations in New York City and New Jersey, 1999–2009 10.1093/ofid/ofw172.417
Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol 10.1111/j.1365-2958.2005.04717.x
Molecular Epidemiology of Multidrug-Resistant Tuberculosis, New York City, 1995–1997 10.3201/eid0811.020288
BCG Induces Protection against Mycobacterium tuberculosis Infection in the Wistar Rat Model 10.1371/journal.pone.0028082
Enhanced bacterial virulence through exploitation of host glycosaminoglycans 10.1046/j.1365-2958.2002.02841.x
Detecting the molecular scars of evolution in the Mycobacterium tuberculosis complex by analyzing interrupted coding sequences 10.1186/1471-2148-8-78
A novel and more sensitive loop-mediated isothermal amplification assay targeting IS6110 for detection of Mycobacterium tuberculosis complex 10.1016/j.micres.2009.05.001
Identification and Evolution of an IS6110Low‐Copy‐NumberMycobacterium tuberculosisCluster 10.1086/339345
Nosocomial Transmission of a Drug-Sensitive W-Variant Mycobacterium tuberculosis Strain among Patients with Acquired Immunodeficiency Syndrome in Tennessee 10.1086/647889
Mutations in Putative Mutator Genes ofMycobacterium tuberculosisStrains of the W-Beijing Family 10.3201/eid0907.020803
Exploring the Mode of Action of Bioactive Compounds by Microfluidic Transcriptional Profiling in Mycobacteria 10.1371/journal.pone.0069191
Characterization of a putative α-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis 10.1042/bj3630437
Persistence of a Highly Resistant Strain of Tuberculosis in New York City during 1990–1999 10.1086/376837
Increased Vancomycin Susceptibility in Mycobacteria: a New Approach To Identify Synergistic Activity against Multidrug-Resistant Mycobacteria 10.1128/aac.04856-14
Nosocomial Transmission of a Drug-Sensitive W-Variant Mycobacterium tuberculosis Strain among Patients with Acquired Immunodeficiency Syndrome in Tennessee 10.2307/30141525
Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis 10.1016/j.bbrc.2015.09.133
Molecular evidence suggestive of intrauterine transmission of Neisseria meningitidis serogroup A from mother to infant 10.1055/s-0035-1557014
Synthetic EthR inhibitors boost antituberculous activity of ethionamide 10.1038/nm.1950
Characterization of a putative α-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis 10.1042/0264-6021:3630437
The nature and consequence of genetic variability within Mycobacterium tuberculosis 10.1172/jci11426
Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family 10.1001/jama.275.6.452
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La PCR en temps réel : principe et application en infectiologie 10.1016/s1294-5501(07)91380-1
Molecular Epidemiology of Tuberculosis: Current Insights 10.1128/cmr.00061-05
A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicatingMycobacterium tuberculosis 10.1021/cb2004884
Corrrection to Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Novel Antitubercular Agents 10.1021/ml500020r
Experimental Tuberculosis in the Wistar Rat: A Model for Protective Immunity and Control of Infection 10.1371/journal.pone.0018632
Mutations in Genes for the F420Biosynthetic Pathway and a Nitroreductase Enzyme Are the Primary Resistance Determinants in SpontaneousIn Vitro-Selected PA-824-Resistant Mutants of Mycobacterium tuberculosis 10.1128/aac.00308-15
CC8 MRSA Strains Harboring SCCmec Type IVc are Predominant in Colombian Hospitals 10.1371/journal.pone.0038576
The Evolution of Drug Resistance inMycobacterium tuberculosis:From a Mono–Rifampin‐Resistant Cluster into Increasingly Multidrug‐Resistant Variants in an HIV‐Seropositive Population 10.1086/588822
Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents 10.1021/jm4012774
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The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. 10.1038/s41598-017-02440-6
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para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. 10.1074/jbc.m113.475798
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Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study. 10.1007/s10096-011-1200-7
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Biochemical and immunological characterization of a cpn60.1 knockout mutant of Mycobacterium bovis BCG. 10.1099/mic.0.045120-0
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy. 10.1038/ncomms1060
Variable-number tandem repeat 3690 polymorphism in Indian clinical isolates of Mycobacterium tuberculosis and its influence on transcription. 10.1099/jmm.0.002550-0
Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis. 10.1128/aac.01197-08
Genotyping of Mycobacterium tuberculosis clinical isolates using IS6110-based restriction fragment length polymorphism analysis. 10.1007/978-1-60327-999-4_14
IS1096-mediated DNA rearrangements play a key role in genome evolution of Mycobacterium smegmatis. 10.1016/j.tube.2008.02.003
Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY. 10.1128/iai.00410-07
Molecular and epidemiological evidence for spread of multiresistant methicillin-susceptible Staphylococcus aureus strains in hospitals. 10.1128/aac.01414-06
Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis. 10.1128/jcm.01392-06
Targeted hybridization of IS6110 fingerprints identifies the W-Beijing Mycobacterium tuberculosis strains among clinical isolates. 10.1128/jcm.43.5.2148-2154.2005
Immunological characterization of novel secreted antigens of Mycobacterium tuberculosis. 10.1111/j.0300-9475.2005.01557.x
Definition of the Beijing/W lineage of Mycobacterium tuberculosis on the basis of genetic markers. 10.1128/jcm.42.9.4040-4049.2004
Snapshot of moving and expanding clones of Mycobacterium tuberculosis and their global distribution assessed by spoligotyping in an international study. 10.1128/jcm.41.5.1963-1970.2003
Global distribution of Mycobacterium tuberculosis spoligotypes. 10.3201/eid0811.020125
Spoligologos: a bioinformatic approach to displaying and analyzing Mycobacterium tuberculosis data. 10.3201/eid0811.020174
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Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain. 10.3201/eid0705.010512
Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis. 10.1128/iai.69.9.5936-5939.2001
Use of spoligotype analysis to detect laboratory cross-contamination. 10.1086/501799
MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis-specific, delayed-type hypersensitivity in guinea pigs. 10.1128/iai.68.2.990-993.2000
Characterization of the phylogenetic distribution and chromosomal insertion sites of five IS6110 elements in Mycobacterium tuberculosis: non-random integration in the dnaA-dnaN region. 10.1054/tuld.1998.0003
Quantitative Proteomic Analysis of Simian Primary Hepatocytes Reveals Candidate Molecular Markers for Permissiveness to Relapsing Malaria Plasmodium cynomolgi. 10.1002/pmic.201900021
Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages. 10.1038/s41467-019-11332-4
Hepatic spheroids used as an in vitro model to study malaria relapse. 10.1016/j.biomaterials.2019.05.032
The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development. 10.7554/eLife.43362
The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model. 10.1186/s13756-018-0448-4
Imidazolopiperazines Kill both Rings and Dormant Rings in Wild-Type and K13 Artemisinin-Resistant Plasmodium falciparum In Vitro. 10.1128/AAC.02235-17
A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi. 10.7554/eLife.29605
Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi. 10.1182/blood-2017-02-764787
Nathalie deboosere
deboosere Nathalie
ORCID: 0000-0002-2873-5485
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. 10.1016/j.celrep.2017.08.101
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. 10.3390/toxins9070227
Phenotypic assays for Mycobacterium tuberculosis infection. 10.1002/cyto.a.23129
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. 10.1021/acschembio.7b00091
STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection. 10.1038/srep29297
LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. 10.1111/cmi.12619
A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114
Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces. 10.1016/j.fm.2012.04.007
Viral elution and concentration method for detection of influenza A viruses in mud by real-time RT-PCR. 10.1016/j.jviromet.2011.10.013
Comparison of chlorine and peroxyacetic-based disinfectant to inactivate Feline calicivirus, Murine norovirus and Hepatitis A virus on lettuce. 10.1016/j.ijfoodmicro.2011.08.011
Direct detection of highly pathogenic avian influenza A/H5N1 virus from mud specimens. 10.1016/j.jviromet.2011.06.002
Development and validation of a concentration method for the detection of influenza a viruses from large volumes of surface water. 10.1128/aem.02484-10
A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries. 10.1016/j.fm.2010.05.018
Assessment of the removal and inactivation of influenza viruses H5N1 and H1N1 by drinking water treatment. 10.1016/j.watres.2010.01.013
Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables. 10.1016/j.ijfoodmicro.2005.11.007
Modelling effect of physical and chemical parameters on heat inactivation kinetics of hepatitis A virus in a fruit model system. 10.1016/j.ijfoodmicro.2003.10.015
Host-pathogen systems for early drug discovery against tuberculosis. 10.1016/j.mib.2017.11.017
Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids. 10.1073/pnas.1707840114
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis. 10.1038/s41598-017-11843-4
Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages. 10.1016/j.chom.2017.07.020
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles. 10.1038/s41598-017-05453-3
Host-directed therapies offer novel opportunities for the fight against tuberculosis. 10.1016/j.drudis.2017.05.005
Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs. 10.1016/j.ijpharm.2017.05.030
Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis. 10.3389/fcimb.2017.00137
Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections. 10.2217/nnm-2016-0364
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. 10.1126/science.aag1006
How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 10.1007/s00401-016-1652-z
Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. 10.1111/mmi.13535
Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization. 10.1016/j.str.2016.07.009
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro. 10.1007/s00705-016-2771-5
[Mycolactone: the amazing analgesic mycobacterial toxin]. 10.1051/medsci/20163202007
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Marie KEMPF
KEMPF Marie
ORCID: 0000-0002-2943-7500
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Detection of Acinetobacter baumannii in human head and body lice from Ethiopia and identification of new genotypes 10.1016/j.ijid.2012.05.1024
Colistin-glycopeptide combinations against multidrug-resistant Acinetobacter baumannii in a mouse model of pneumonia 10.2217/fmb-2019-0022
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Semisynthetic Vitamin E Derivatives as Potent Antibacterial Agents against Resistant Gram-Positive Pathogens 10.1002/cmdc.202000792
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Epidemiology and prevalence of extended-spectrum β-lactamase- and carbapenemase-producing Enterobacteriaceae in humans, animals and the environment in West and Central Africa 10.1016/j.ijantimicag.2020.106203
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Assessment of the usefulness of performing bacterial identification and antimicrobial susceptibility testing 24 h a day in a clinical microbiology laboratory 10.1111/j.1469-0691.2009.03044.x
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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis 10.1038/nm.3262
First report of carbapenemase-producing Acinetobacter baumannii carriage in pets from the community in France 10.1016/j.ijantimicag.2016.03.012
Evaluation of an immunomagnetic separation method to capture Candida yeasts cells in blood 10.1186/1471-2180-8-157
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The virulence variability of different Acinetobacter baumannii strains in experimental pneumonia 10.1016/j.jinf.2009.09.004
Performance of the extended use of the FilmArray® BCID panel kit for bronchoalveolar lavage analysis 10.1007/s11033-019-04710-0
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Reservoirs of Acinetobacter baumannii outside the hospital and potential involvement in emerging human community-acquired infections 10.1016/j.ijid.2013.03.021
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Antifungal and antibacterial metabolites from a French poplar type propolis 10.1155/2015/319240
Impact of improving glove usage on the hand hygiene compliance 10.1016/j.ajic.2010.08.022
Impact of a multi-faceted training intervention on the improvement of hand hygiene and gloving practices in four healthcare settings including nursing homes, acute-care geriatric wards and physical rehabilitation units 10.1111/j.1365-2702.2011.03704.x
A case of Ureaplasma parvum meningitis in an adult after transphenoidal ablation of craniopharyngioma 10.1016/j.ijid.2019.04.024
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Acinetobacter pittii isolated more frequently than Acinetobacter baumannii in blood cultures: the experience of a French hospital 10.1016/j.jhin.2018.03.019
Kevin Pethe
Pethe Kevin
ORCID: 0000-0003-0916-8873
Bedaquiline inhibits the ATP synthase in mycobacterium abscessus and is effective in infected zebrafish 10.1128/AAC.01225-17
Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis: An essential role for NAD in nonreplicating bacilli 10.1074/jbc.M800694200
Nanoparticles of Short Cationic Peptidopolysaccharide Self-Assembled by Hydrogen Bonding with Antibacterial Effect against Multidrug-Resistant Bacteria 10.1021/acsami.7b12120
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection 10.1073/pnas.1000715107
Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents 10.1021/ml400071a
Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria 10.1074/jbc.RA118.005732
Microbiomes in respiratory health and disease: An Asia-Pacific perspective 10.1111/resp.12971
Next-generation antimicrobials: From chemical biology to first-in-class drugs 10.1007/s12272-015-0645-0
Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia 10.1371/journal.pone.0056037
Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis 10.1128/IAI.70.5.2256-2263.2002
New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis 10.1371/journal.ppat.1008270
Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer 10.1038/s41467-018-07804-8
Target Engagement and Binding Mode of an Antituberculosis Drug to Its Bacterial Target Deciphered in Whole Living Cells by NMR 10.1021/acs.biochem.8b00975
Oxidative phosphorylation as a target space for tuberculosis: Success, caution, and future directions 10.1128/microbiolspec.TBTB2-0014-2016
EthA/R-independent killing of Mycobacterium tuberculosis by ethionamide 10.3389/fmicb.2017.00710
Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturation 10.1073/pnas.0401657101
Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis 10.1074/jbc.M113.475798
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis 10.1126/scitranslmed.3007355
The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination 10.1038/35084083
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The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis 10.1073/pnas.0711697105
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The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD 10.1111/resp.13032
Triacylglycerol utilization is required for regrowth of in vitro hypoxic nonreplicating Mycobacterium bovis bacillus Calmette-Guerin 10.1128/JB.00530-09
Lead optimization of a novel series of imidazo[1,2-a]pyridine amides leading to a clinical candidate (Q203) as a multi- and extensively-drug- resistant anti-tuberculosis agent 10.1021/jm5003606
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy 10.1038/ncomms1060
Naturally-Occurring Polymorphisms in QcrB Are Responsible for Resistance to Telacebec in Mycobacterium abscessus 10.1021/acsinfecdis.9b00322
Arylvinylpiperazine amides, a new class of potent inhibitors targeting QcrB of mycobacterium tuberculosis 10.1128/mBio.01276-18
Nitrate respiration protects hypoxic Mycobacterium tuberculosisagainst acid- and reactive nitrogen species stresses 10.1371/journal.pone.0013356
The natural product cyclomarin kills mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease 10.1002/anie.201101740
Active pulmonary targeting against tuberculosis (TB) via triple-encapsulation of Q203, bedaquiline and superparamagnetic iron oxides (SPIOs) in nanoparticle aggregates 10.1080/10717544.2019.1676841
Contribution of high-content imaging technologies to the development of anti-infective drugs 10.1002/cyto.a.22885
Role of the CD137 ligand (CD137L) signaling pathway during Mycobacterium tuberculosis infection 10.1016/j.imbio.2013.08.009
Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability 10.1099/mic.0.033084-0
Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosis 10.1086/338833
A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria 10.1038/ncomms12527
Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis 10.1073/pnas.162246899
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis 10.1038/nm.3262
Sensitive profiling of chemically diverse bioactive lipids 10.1194/jlr.M700060-JLR200
Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy 10.1073/pnas.0700036104
Eighty-kilodalton N-terminal moiety of Bordetella pertussis filamentous hemagglutinin: Adherence, immunogenicity, and protective role 10.1128/IAI.70.8.4142-4147.2002
Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin 10.1099/00221287-148-4-1193
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters 10.1038/s41467-019-12702-8
Carbon metabolism modulates the efficacy of drugs targeting the cytochrome bc 1 :aa 3 in Mycobacterium tuberculosis 10.1038/s41598-019-44887-9
High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis 10.1128/AAC.03705-14
Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin 10.1038/nm1090
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Role of ADP-ribosyltransferase activity of pertussis toxin in toxin-adhesin redundancy with filamentous hemagglutinin during Bordetella pertussis infection 10.1128/IAI.69.10.6038-6043.2001
Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis 10.1016/j.coph.2018.06.006
Enhanced bacterial virulence through exploitation of host glycosaminoglycans 10.1046/j.1365-2958.2002.02841.x
Characterization of the heparin-binding site of the mycobacterial heparin-binding hemagglutinin adhesin 10.1074/jbc.275.19.14273
An ethA-ethR-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo, which correlate with altered mycolic acid composition 10.1128/IAI.01332-13
Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection 10.1073/pnas.1706139114
A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating mycobacterium tuberculosis 10.1021/cb2004884
Tuberculose, la porte vers la dissémination extra-pulmonaire 10.1051/medsci/200117111220
Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence 10.1128/IAI.73.3.1898-1902.2005
Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran