Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
Mingxun Wang Jeremy J. Carver Pavel Pevzner Hosein Mohiman Nuno Bandeira Vanessa V. Phelan Laura M. Sanchez Neha Garg Jeramie Watrous Tal Luzzatto-Knaa Charlotte Frydenlund Michelsen Lars Jelsbak Maria Månsson Andreas Klitgaard Kristian Fog Nielsen
Nature Biotechnology, 2016-8
https://doi.org/10.1038/nbt.3597
Mingxun Wang
Wang Mingxun / Ming
ORCID: 0000-0001-7647-6097
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking 10.1038/nbt.3597
Detection of Ovarian Cancer Using Samples Sourced from the Vaginal Microenvironment 10.1101/597740
MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools 10.1101/654459
Repository-scale Co- and Re-analysis of Tandem Mass Spectrometry Data 10.1101/750471
Protocol for Community-created Public MS/MS Reference Library Within the GNPS Infrastructure 10.1101/804401
Protocol for community‐created public MS/MS reference spectra within the Global Natural Products Social Molecular Networking infrastructure 10.1002/rcm.8725
Universal MS/MS Visualization and Retrieval with the Metabolomics Spectrum Resolver Web Service 10.1101/2020.05.09.086066
Ion Identity Molecular Networking in the GNPS Environment 10.1101/2020.05.11.088948
ReDU: a framework to find and reanalyze public mass spectrometry data 10.1038/s41592-020-0916-7
The ant fungus garden acts as an external digestive system 10.1101/2020.11.18.389361
A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria 10.3390/md19010020
Ion identity molecular networking for mass spectrometry-based metabolomics in the GNPS environment 10.1038/s41467-021-23953-9
Quick-start infrastructure for untargeted metabolomics analysis in GNPS 10.1038/s42255-021-00429-0
Chemical Gradients of Plant Substrates in an Atta texana Fungus Garden 10.1128/mSystems.00601-21
A Synthesis-Based Reverse Metabolomics Approach for the Discovery of Chemical Structures from Humans and Animals. 10.21203/rs.3.rs-820302/v1
Native Metabolomics Identifies the Rivulariapeptolide Family of Protease Inhibitors 10.1101/2021.09.03.458897
Bradley Moore
Moore Bradley
ORCID: 0000-0002-4652-1253
Coupled Biosynthesis of Volatiles and Salinosporamide A in Salinispora tropica 10.1002/cbic.201600388
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse 10.1021/acs.chemrev.6b00571
PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete 10.1021/acs.jnatprod.6b01121
Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols 10.1021/acs.jnatprod.6b00722
Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation 10.1002/cbic.201700090
Back Cover: Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation (ChemBioChem 12/2017) 10.1002/cbic.201700270
A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis 10.1038/nchem.2829
Function-related replacement of bacterial siderophore pathways 10.1038/ismej.2017.137
Enzymatic C−H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity 10.1002/ange.201705239
Enzymatic C−H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity 10.1002/anie.201705239
Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis 10.1055/s-0036-1590919
Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster 10.1038/ja.2017.146
Biosynthesis of the Antibiotic Bicyclomycin in Soil and Pathogenic Bacteria 10.1021/acs.biochem.7b01204
Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics 10.1021/acs.est.8b00512
Enzymatic control of dioxygen binding and functionalization of the flavin cofactor. 10.1073/pnas.1801189115
Natural Product Reports 35 years on. 10.1039/c8np90001a
Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. 10.1073/pnas.1714381115
Broad-Host-Range Expression Reveals Native and Host Regulatory Elements That Influence Heterologous Antibiotic Production in Gram-Negative Bacteria. 10.1128/mbio.01291-17
Genomic insights into specialized metabolism in the marine actinomycete Salinispora. 10.1111/1462-2920.13867
Editorial: Are natural products the solution to antimicrobial resistance? 10.1039/c7np90026k
Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. 10.1038/nchembio.2330
Erratum: Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. 10.1038/nmicrobiol.2017.10
Effects of Actinomycete Secondary Metabolites on Sediment Microbial Communities. 10.1128/aem.02676-16
Family-wide Structural Characterization and Genomic Comparisons Decode the Diversity-oriented Biosynthesis of Thalassospiramides by Marine Proteobacteria. 10.1074/jbc.m116.756858
Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids. 10.1016/j.chembiol.2016.10.009
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. 10.1038/nmicrobiol.2016.197
Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. 10.1099/mic.0.000386
Enzymatic Reductive Dehalogenation Controls the Biosynthesis of Marine Bacterial Pyrroles. 10.1021/jacs.6b08512
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. 10.1038/nchembio.2157
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. 10.1073/pnas.1519695113
A Bacterial Quorum-Sensing Precursor Induces Mortality in the Marine Coccolithophore, Emiliania huxleyi. 10.3389/fmicb.2016.00059
Unusual flavoenzyme catalysis in marine bacteria. 10.1016/j.cbpa.2016.01.001
Recent advances in the biosynthesis of unusual polyketide synthase substrates. 10.1039/c5np00112a
A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis. 10.1002/anie.201508576
Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. 10.1021/acschembio.5b00658
Erratum: Reinvigorating natural product combinatorial biosynthesis with synthetic biology. 10.1038/nchembio1115-887a
Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins. 10.1021/acs.orglett.5b02113
Reinvigorating natural product combinatorial biosynthesis with synthetic biology. 10.1038/nchembio.1893
Minimum Information about a Biosynthetic Gene cluster. 10.1038/nchembio.1890
Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor. 10.1021/jacs.5b03983
Microbial and biochemical basis of a Fusarium wilt-suppressive soil. 10.1038/ismej.2015.95
Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase. 10.1002/cbic.201500177
The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. 10.1039/c4np00167b
Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. 10.1016/j.chembiol.2015.03.010
Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis. 10.1038/srep09383
Mechanism of action of thalassospiramides, a new class of calpain inhibitors. 10.1038/srep08783
Special issue in honor of William Fenical, a pioneer in marine natural products discovery and drug development. 10.1021/acs.jnatprod.5b00146
Digging for biosynthetic dark matter. 10.7554/elife.06453
Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry. 10.1021/es505440j
Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway. 10.1111/1462-2920.12669
Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin. 10.1021/np500664q
Correction to “Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases”. 10.1021/ja509209d
Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola. 10.1021/np500422d
Targeted capture and heterologous expression of the Pseudoalteromonas alterochromide gene cluster in Escherichia coli represents a promising natural product exploratory platform. 10.1021/sb500280q
A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins. 10.1002/anie.201405696
One-pot enzymatic synthesis of merochlorin A and B. 10.1002/anie.201405694
NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery. 10.1021/np500370c
Fungal polyketide engineering comes of age. 10.1073/pnas.1412946111
Enzymatic synthesis of polybrominated dioxins from the marine environment. 10.1021/cb5004338
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. 10.1038/nchembio.1564
Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. 10.1016/j.chembiol.2014.04.010
Automated genome mining of ribosomal peptide natural products. 10.1021/cb500199h
Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib). 10.1124/mol.114.092114
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. 10.1073/pnas.1319584111
Biosynthesis: Non-stick natural products. 10.1038/nchem.1828
Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine A. 10.1021/ja409520v
Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. 10.1021/cb400699p
Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. 10.1073/pnas.1315492110
Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. 10.1038/nature12643
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. 10.1038/ja.2013.99
Challenges and triumphs to genomics-based natural product discovery. 10.1007/s10295-013-1353-8
Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. 10.1021/bi400572a
MS/MS networking guided analysis of molecule and gene cluster families. 10.1073/pnas.1303471110
A tandem chemoenzymatic methylation by S-adenosyl-L-methionine. 10.1002/cbic.201300221
Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. 10.1002/cbic.201300147
Structures and comparative characterization of biosynthetic gene clusters for cyanosporasides, enediyne-derived natural products from marine actinomycetes. 10.1021/ja311065v
Biosynthetic multitasking facilitates thalassospiramide structural diversity in marine bacteria. 10.1021/ja3119674
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. 10.1039/c2np20085f
Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering. 10.1021/sb3001062
Molecular mechanisms of acquired proteasome inhibitor resistance. 10.1021/jm300434z
Mechanistic studies on CymD: a tryptophan reverse N-prenyltransferase. 10.1021/bi3009054
Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway. 10.1002/cbic.201200406
Editorial: structural aspects of biosynthesis themed issue. 10.1039/c2np90032g
Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. 10.1111/j.1574-6968.2012.02641.x
Primer on agar-based microbial imaging mass spectrometry. 10.1128/jb.00823-12
Flavoenzyme-catalyzed atropo-selective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis. 10.1021/ja305670f
Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. 10.1021/ja305665f
Mass spectral molecular networking of living microbial colonies. 10.1073/pnas.1203689109
Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. 10.1021/ja301735a
The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium. 10.1002/cbic.201200007
Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. 10.1111/j.1742-4658.2012.08517.x
Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. 10.1074/jbc.m112.349860
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. 10.1016/j.chembiol.2011.12.014
Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. 10.1016/j.chembiol.2011.10.014
Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. 10.1039/c1np00082a
Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus. 10.1021/ja2040877
A mass spectrometry-guided genome mining approach for natural product peptidogenomics. 10.1038/nchembio.684
Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. 10.1021/cb2002544
Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. 10.1021/ja205655w
Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. 10.1002/anie.201101225
Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. 10.1016/j.bmc.2011.04.024
Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. 10.1128/aem.00038-11
A stereoselective vanadium-dependent chloroperoxidase in bacterial antibiotic biosynthesis. 10.1021/ja201088k
Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. 10.1021/ja109226s
The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. 10.1002/cbic.201000564
A sea of biosynthesis: marine natural products meet the molecular age. 10.1039/c0np90032j
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. 10.1021/ja108399b
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics. 10.1002/anie.201000728
Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites. 10.1021/bi101457h
Shared biosynthesis of the saliniketals and rifamycins in Salinispora arenicola is controlled by the sare1259-encoded cytochrome P450. 10.1021/ja105891a
Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling. 10.1074/jbc.m110.153833
Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. 10.1021/ja102751h
Richard E. Moore (1933-2007). 10.1021/np100045f
Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide. 10.1021/np900719u
Functional characterization of the cyclomarin/cyclomarazine prenyltransferase CymD directs the biosynthesis of unnatural cyclic peptides. 10.1021/np9006876
Total (bio)synthesis: strategies of nature and of chemists. 10.1007/128_2010_79
Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. 10.1021/jm901098m
Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62). 10.1002/cbic.200900369
Genomic basis for natural product biosynthetic diversity in the actinomycetes. 10.1039/b817069j
Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity. 10.1021/ja9042824
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. 10.1073/pnas.0901237106
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. 10.1021/ac900114t
Chasing the treasures of the sea - bacterial marine natural products. 10.1016/j.mib.2009.05.002
Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. 10.1038/ismej.2009.58
Exploring the chemistry and biology of vanadium-dependent haloperoxidases. 10.1074/jbc.r109.001602
Alkaloid biosynthesis takes root. 10.1038/nchembio0309-140
In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides. 10.1021/np800598t
Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone. 10.1002/anie.200805140
S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. 10.1002/cbic.200800341
Probing the compatibility of type II ketosynthase-carrier protein partners. 10.1002/cbic.200800198
Advances in and applications of proteasome inhibitors. 10.1016/j.cbpa.2008.06.033
Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. 10.1021/ja8029398
Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. 10.1021/ja711188x
Unraveling the biosynthesis of the sporolide cyclohexenone building block. 10.1021/ja710488m
Extending the biosynthetic repertoire in ribosomal peptide assembly. 10.1002/anie.200803868
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. 10.1002/anie.200800177
Discovery and characterization of a marine bacterial SAM-dependent chlorinase. 10.1038/nchembio.2007.56
Enzymatic total synthesis of enterocin polyketides. 10.1038/nchembio.2007.22
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. 10.1073/pnas.0700962104
Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. 10.1074/jbc.m611046200
Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. 10.1021/ol063102o
Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. 10.1021/bi061774g
Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. 10.1016/j.chembiol.2006.11.011
Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. 10.1021/ja065247w
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. 10.1038/nchembio811
Biosynthesis of marine natural products: macroorganisms (Part B). 10.1039/b508781n
Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase. 10.1021/cb500007v
Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism. 10.1021/ja0559707
Biosynthesis of marine natural products: microorganisms (Part A). 10.1039/b404737k
Biochemical characterization of a prokaryotic phenylalanine ammonia lyase. 10.1128/jb.187.12.4286-4289.2005
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. 10.1074/jbc.m410933200
Exploiting marine actinomycete biosynthetic pathways for drug discovery. 10.1007/s10482-004-6541-0
EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions. 10.1073/pnas.0405508101
Engineered biosynthesis of phenyl-substituted polyketides. 10.1002/cbic.200400007
Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase. 10.1021/np0499564
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. 10.1074/jbc.m406567200
Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction. 10.1016/j.chembiol.2004.03.018
Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization. 10.1016/j.gene.2003.09.034
Biosynthesis and structural revision of neomarinone. 10.1021/ol035748b
Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). 10.1007/s10295-003-0075-8
Mutasynthesis of enterocin and wailupemycin analogues. 10.1021/ja035973o
Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224. 10.1016/s0378-1119(03)00587-0
Characterization of benzoyl coenzyme A biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus". 10.1128/jb.185.2.399-404.2003
Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. 10.1021/np020230m
Molecular evidence for a uniform microbial community in sponges from different oceans. 10.1128/aem.68.9.4431-4440.2002
Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene. 10.1074/jbc.m204171200
Mutational analysis of the enterocin favorskii biosynthetic rearrangement. 10.1021/ol0255155
Biosynthesis and attachment of novel bacterial polyketide synthase starter units. 10.1039/b003939j
A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation. 10.1002/1439-7633(20011001)2:10<784::aid-cbic784>3.0.co;2-k
Discovery of a new bacterial polyketide biosynthetic pathway. 10.1002/1439-7633(20010105)2:1<35::aid-cbic35>3.3.co;2-t
Engineering biodiversity with type II polyketide synthase genes. 10.1023/a:1010273224820
Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. 10.1016/s1074-5521(00)00044-2
Biosynthesis of marine natural products: microorganisms and macroalgae. 10.1039/a805873c
Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. 10.1073/pnas.96.16.9051
Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes. 10.1073/pnas.96.7.3622
Biosynthetic Studies of omega-Cycloheptyl Fatty Acids in Alicyclobacillus cycloheptanicus. Formation of Cycloheptanecarboxylic Acid from Phenylacetic Acid. 10.1021/jo962402o
Oleic Acid and Its Positional Isomer, cis-Vaccinic Acid, in the Appendix of Sauromatum guttatum during Anthesis. 10.1104/pp.107.4.1433
Three new omega-cycloheptyl fatty acids from Alicyclobacillus cycloheptanicus and their biosynthetic interrelationships. 10.1021/np50118a019
Biosynthetic studies on the origin of the cyclohexanecarboxylic acid moiety of ansatrienin A and omega-cyclohexyl fatty acids. 10.1021/np50105a008
Correction to Organohalogens Naturally Biosynthesized in Marine Environments and Produced As Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics 10.1021/acs.est.8b03174
Pangenomic comparison of globally distributed Poribacteria associated with sponge hosts and marine particles 10.1038/s41396-018-0292-9
Structural Elucidation of Trace Components Combining GC/MS, GC/IR, DFT-Calculation and Synthesis-Salinilactones, Unprecedented Bicyclic Lactones from Salinispora Bacteria 10.1002/anie.201807923
Strukturaufklärung von Spurenkomponenten durch Kombination von GC/MS, GC/IR, DFT-Simulationen und Synthese - Salinilactone, neuartige bicyclische Lactone aus Salinispora Bakterien 10.1002/ange.201807923
The chemical cue tetrabromopyrrole induces rapid cellular stress and mortality in phytoplankton 10.1038/s41598-018-33945-3
Total Enzyme Syntheses of Napyradiomycins A1 and B1 10.1021/jacs.8b10134
Insights into Thiotemplated Pyrrole Biosynthesis Gained from the Crystal Structure of Flavin-Dependent Oxidase in Complex with Carrier Protein 10.1021/acs.biochem.8b01177
Enzymatic Cascade Reactions in Biosynthesis 10.1002/anie.201807844
Enzymkaskadenreaktionen in der Biosynthese 10.1002/ange.201807844
Avant-garde assembly-line biosynthesis expands diversity of cyclic lipodepsipeptide products 10.1101/560987
Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom 10.1126/science.aau0382
Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives 10.1039/C8OB03109F
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid 10.1002/anie.201902910
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid 10.1002/ange.201902910
Biosynthesis of l ‐4‐Chlorokynurenine, an Antidepressant Prodrug and a Non‐Proteinogenic Amino Acid Found in Lipopeptide Antibiotics 10.1002/anie.201901571
Biosynthesis of l ‐4‐Chlorokynurenine, an Antidepressant Prodrug and a Non‐Proteinogenic Amino Acid Found in Lipopeptide Antibiotics 10.1002/ange.201901571
Comparative Genomics of Cyanobacterial Symbionts Reveals Distinct, Specialized Metabolism in Tropical Dysideidae Sponges 10.1128/mBio.00821-19
Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase 10.1021/acs.biochem.9b00318
Genetic platforms for heterologous expression of microbial natural products 10.1039/C9NP00025A
Cariogenic Streptococcus mutans produces strain-specific antibiotics that impair commensal colonization 10.1101/755025
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage 10.1038/s41557-019-0317-7
Pass-back chain extension expands multimodular assembly line biosynthesis 10.1038/s41589-019-0385-4
Cariogenic Streptococcus mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization 10.1021/acsinfecdis.9b00365
Algal Neurotoxin Biosynthesis Repurposes the Terpene Cyclase Structural Fold Into an N-prenyltransferase 10.1101/2020.03.31.014811
Nonlinear Biosynthetic Assembly of Alpiniamide by a Hybrid cis/trans-AT PKS-NRPS 10.1021/acschembio.0c00081
Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into anN-prenyltransferase 10.1073/pnas.2001325117
Comparative Genomics and Metabolomics in the Genus Nocardia 10.1128/mSystems.00125-20
Co-Occurrence of Enzyme Domains Guides the Discovery of an Oxazolone Synthetase 10.1101/2020.06.11.147165
Meroterpenoid natural products from Streptomyces bacteria – the evolution of chemoenzymatic syntheses 10.1039/D0NP00018C
Site-Directed Mutagenesis of Large Biosynthetic Gene Clusters via Oligonucleotide Recombineering and CRISPR/Cas9 Targeting 10.1021/acssynbio.0c00265
Biosynthesis of marine toxins 10.1016/j.cbpa.2020.06.009
Genetic examination of the marine bacterium Pseudoalteromonas luteoviolacea and effects of its metamorphosis‐inducing factors 10.1111/1462-2920.15211
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Helfrich Eric Jan Nikolaus
ORCID: 0000-0001-8751-3279
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Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts. 10.1073/pnas.1715496115
An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA. 10.1021/acschembio.6b01115
Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges. 10.1073/pnas.1616234114
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Genome mining reveals trans-AT polyketide synthase directed antibiotic biosynthesis in the bacterial phylum bacteroidetes. 10.1002/cbic.201000542
Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A 10.1126/science.aay9981
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Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A 10.1039/d0cc03055d
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Pace Laura
ORCID: 0000-0002-3311-8342
Draft Genome Sequence of Hydrogenibacillus schlegelii MA48, a Deep-Branching Member of the Bacilli Class of Firmicutes. 10.1128/genomea.00380-16
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Complex Relationships Between Food, Diet, and the Microbiome. 10.1016/j.gtc.2016.02.004
Genomics of a phototrophic nitrite oxidizer: insights into the evolution of photosynthesis and nitrification. 10.1038/ismej.2016.56
Draft Genome Sequence of Ardenticatena maritima 110S, a Thermophilic Nitrate- and Iron-Reducing Member of the Chloroflexi Class Ardenticatenia. 10.1128/genomea.01347-15
Draft Genome Sequence of Herpetosiphon geysericola GC-42, a Nonphototrophic Member of the Chloroflexi Class Chloroflexia. 10.1128/genomea.01352-15
Draft Genome Sequence of Ornatilinea apprima P3M-1, an Anaerobic Member of the Chloroflexi Class Anaerolineae. 10.1128/genomea.01353-15
Draft Genome of Thermanaerothrix daxensis GNS-1, a Thermophilic Facultative Anaerobe from the Chloroflexi Class Anaerolineae. 10.1128/genomea.01354-15
Draft Genome Sequence of Leptolinea tardivitalis YMTK-2, a Mesophilic Anaerobe from the Chloroflexi Class Anaerolineae. 10.1128/genomea.01356-15
Draft Genome Sequence of Levilinea saccharolytica KIBI-1, a Member of the Chloroflexi Class Anaerolineae. 10.1128/genomea.01357-15
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The intergeniculate leaflet, but not the visual midbrain, mediates hamster circadian rhythm response to constant light. 10.1177/07430402017003005
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ORCID: 0000-0002-7868-3345
Chromosome segregation in Eubacteria 10.1016/j.mib.2003.10.015
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Forespore Engulfment Mediated by a Ratchet-Like Mechanism 10.1016/j.cell.2006.06.053
Application of bacterial cytological profiling to crude natural product extracts reveals the antibacterial arsenal of Bacillus subtilis 10.1038/ja.2015.116
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Functional requirements for bacteriophage growth: gene essentiality and expression in mycobacteriophage Giles 10.1111/mmi.12210
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Bacterial Cytological Profiling (BCP) as a Rapid and Accurate Antimicrobial Susceptibility Testing Method for Staphylococcus aureus 10.1016/j.ebiom.2016.01.020
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Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature. 10.1128/jb.171.5.2689-2696.1989
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Dynamic SpoIIIE assembly mediates septal membrane fission during Bacillus subtilis sporulation. 10.1101/gad.1925210
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SpoIIB localizes to active sites of septal biogenesis and spatially regulates septal thinning during engulfment in bacillus subtilis. 10.1128/jb.182.4.1096-1108.2000
An in vivo membrane fusion assay implicates SpoIIIE in the final stages of engulfment during Bacillus subtilis sporulation. 10.1073/pnas.96.25.14553
Pep Charusanti
Charusanti Pep
ORCID: 0000-0003-0009-6615
CRISPR-Cas9 Based Engineering of Actinomycetal Genomes 10.1021/acssynbio.5b00038
Microbial regulatory and metabolic networks 10.1016/j.copbio.2007.07.002
Reconciling a Salmonella enterica metabolic model with experimental data confirms that overexpression of the glyoxylate shunt can rescue a lethal ppc deletion mutant 10.1111/1574-6968.12109
Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes 10.1016/j.tibtech.2014.10.009
An experimentally-supported genome-scale metabolic network reconstruction for Yersinia pestis CO92 10.1186/1752-0509-5-163
A mathematical model of BCR-ABL autophosphorylation, signaling through the CRKL pathway, and Gleevec dynamics in chronic myeloid leukemia 10.3934/dcdsb.2004.4.99
Multiple-omic data analysis of Klebsiella pneumoniae MGH 78578 reveals its transcriptional architecture and regulatory features 10.1186/1471-2164-13-679
Capsule deletion via a λ-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578 10.1186/1756-0500-7-13
Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters 10.1186/1752-0509-8-4
Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction 10.1371/journal.pone.0033727
Genetic Basis of Growth Adaptation of Escherichia coli after Deletion of pgi, a Major Metabolic Gene 10.1371/journal.pgen.1001186
Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites 10.1016/j.biotechadv.2013.10.008
Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC 10.3389/fmicb.2015.00958
Studying Salmonellae and Yersiniae Host–Pathogen Interactions Using Integrated ‘Omics and Modeling 10.1007/82_2012_247
Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models 10.1038/msb.2010.47
Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations 10.1038/srep16025
Systems biology definition of the core proteome of metabolism and expression is consistent with high-throughput data 10.1073/pnas.1501384112
A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2 10.1186/1752-0509-5-8
A Gapless, Unambiguous Genome Sequence of the Enterohemorrhagic Escherichia coli O157:H7 Strain EDL933 10.1128/genomea.00821-14
Genome-scale metabolic reconstructions of multiple Escherichia coli strains highlight strain-specific adaptations to nutritional environments 10.1073/pnas.1307797110
MS/MS networking guided analysis of molecule and gene cluster families 10.1073/pnas.1303471110
An Experimentally Validated Genome-Scale Metabolic Reconstruction of Klebsiella pneumoniae MGH 78578, iYL1228 10.1128/jb.01218-10
Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites 10.1039/c6np00019c
The aldehyde dehydrogenase, AldA, is essential for L-1,2-propanediol utilization in laboratory-evolved Escherichia coli 10.1016/j.micres.2016.10.006
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
Dissemination of antibiotic resistance genes from antibiotic producers to pathogens 10.1038/ncomms15784
Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast 10.1016/j.synbio.2020.01.004
Complete genome sequence of the rare actinobacterium Kutzneria sp. Strain CA-103260 10.1128/MRA.00499-21
Philip Williams
Williams Philip
ORCID: 0000-0001-8987-0683
Characterization of Leptazolines A-D, Polar Oxazolines from the Cyanobacterium Leptolyngbya sp., Reveals a Glitch with the "Willoughby-Hoye" Scripts for Calculating NMR Chemical Shifts. 10.1021/acs.orglett.9b03216
Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans. 10.3390/md17070423
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. 10.1039/c8np90041h
Genome sequence, metabolic properties and cyanobacterial attachment of Porphyrobacter sp. HT-58-2 isolated from a filamentous cyanobacterium-microbial consortium. 10.1099/mic.0.000706
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. 10.1039/c7np00064b
Cyanobacteria Scytonema javanicum and Scytonema ocellatum Lipopolysaccharides Elicit Release of Superoxide Anion, Matrix-Metalloproteinase-9, Cytokines and Chemokines by Rat Microglia In Vitro. 10.3390/toxins10040130
Quantitation of Tolyporphins, Diverse Tetrapyrrole Secondary Metabolites with Chlorophyll-Like Absorption, from a Filamentous Cyanobacterium-Microbial Community. 10.1002/pca.2735
Genome Sequence and Composition of a Tolyporphin-Producing Cyanobacterium-Microbial Community. 10.1128/AEM.01068-17
Photophysical Characterization of the Naturally Occurring Dioxobacteriochlorin Tolyporphin A and Synthetic Oxobacteriochlorin Analogues. 10.1111/php.12781
Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass. 10.1021/acs.jnatprod.6b00896
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
A dual-intein autoprocessing domain that directs synchronized protein co-expression in both prokaryotes and eukaryotes. 10.1038/srep08541
Phyllostachys edulis compounds inhibit palmitic acid-induced monocyte chemoattractant protein 1 (MCP-1) production. 10.1371/journal.pone.0045082
Isoflavonoids from Ficus benjamina and their inhibitory activity on BACE1. 10.1055/s-0032-1315001
Daedalols A-C, fungal-derived BACE1 inhibitors. 10.1016/j.bmc.2011.09.029
Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. 10.1186/1742-2094-8-64
Stictamides A-C, MMP12 inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid subunits. 10.1021/jo200241h
Depsipeptides from a Guamanian Marine Cyanobacterium, Lyngbya bouillonii, with Selective Inhibition of Serine Proteases. 10.1016/j.tetlet.2010.10.062
Sebestenoids A-D, BACE1 inhibitors from Cordia sebestena. 10.1016/j.phytochem.2010.09.008
Xestosaprols from the Indonesian marine sponge Xestospongia sp. 10.1021/np100203x
Dictazoles: potential vinyl cyclobutane biosynthetic precursors to the dictazolines. 10.1021/jo902566n
A simple microscale method for determining the relative stereochemistry of statine units. 10.1021/jo8012429
Panning for chemical gold: marine bacteria as a source of new therapeutics. 10.1016/j.tibtech.2008.10.005
Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis. 10.1021/np070101b
Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola. 10.1021/jo061878x
Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. 10.1021/np0604580
Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. 10.1128/AEM.01891-06
Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales). 10.1021/ol060630r
Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus streptomyces (actinomycetales). 10.1021/np050402q
Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica". 10.1021/ol052686b
Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica. 10.1021/ol050901i
Marine actinomycete diversity and natural product discovery. 10.1007/s10482-004-6540-1
Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratum. 10.1021/np049920b
Micromide and guamamide: cytotoxic alkaloids from a species of the marine cyanobacterium Symploca. 10.1021/np030215x
The structure of Palau'amide, a potent cytotoxin from a species of the marine cyanobacterium Lyngbya. 10.1021/np034001r
Isolation and structure determination of lyngbyastatin 3, a lyngbyastatin 1 homologue from the marine cyanobacterium Lyngbya majuscula. Determination of the configuration of the 4-amino-2,2-dimethyl-3-oxopentanoic acid unit in majusculamide C, dolastatin 12, lyngbyastatin 1, and lyngbyastatin 3 from cyanobacteria. 10.1021/np0302145
Novel iodinated diterpenes from a marine cyanobacterium and red alga assemblage. 10.1021/ol035620u
The isolation and structure elucidation of Tasiamide B, a 4-amino-3-hydroxy-5-phenylpentanoic acid containing peptide from the marine Cyanobacterium Symploca sp. 10.1021/np030114z
Ulongapeptin, a cytotoxic cyclic depsipeptide from a Palauan marine cyanobacterium Lyngbya sp. 10.1021/np030050s
Tasipeptins A and B: new cytotoxic depsipeptides from the marine cyanobacterium Symploca sp. 10.1021/np020582t
Continuing studies on the cyanobacterium Lyngbya sp.: isolation and structure determination of 15-norlyngbyapeptin A and lyngbyabellin D. 10.1021/np030011g
Tasiamide, a cytotoxic peptide from the marine cyanobacterium Symploca sp. 10.1021/np020184q
Ulongamides A-F, new beta-amino acid-containing cyclodepsipeptides from Palauan collections of the marine cyanobacterium Lyngbya sp. 10.1021/np0200461
Isolation and structure determination of obyanamide, a novel cytotoxic cyclic depsipeptide from the marine cyanobacterium Lyngbya confervoides. 10.1021/np0102253
The synthesis of hydroxysmirnovine 10.1139/v00-053
New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica. 10.1021/jo050511+
Dictazolines A and B, bisspiroimidazolidinones from the marine sponge Smenospongia cerebriformis. 10.1021/np8001018
Xestosaprol D and E from the Indonesian marine sponge Xestospongia sp. 10.1016/j.tetlet.2009.11.132
Spongiapyridine and Related Spongians Isolated from an Indonesian Spongia sp. 10.1021/np500256w
Effects of cyanobacteria Oscillatoria sp. lipopolysaccharide on B cell activation and Toll-like receptor 4 signaling. 10.1016/j.toxlet.2017.05.013
Areca nut extracts mobilize calcium and release pro-inflammatory cytokines from various immune cells 10.1038/s41598-017-18996-2
Tracing MYC Expression for Small Molecule Discovery. 10.1016/j.chembiol.2019.02.007
Biochemical and Functional Analysis of Cyanobacterium Geitlerinema sp. LPS on Human Monocytes 10.1093/toxsci/kfz153
Mass spectrometric detection of chlorophyll a and the tetrapyrrole secondary metabolite tolyporphin A in the filamentous cyanobacterium HT-58-2. Approaches to high-throughput screening of intact cyanobacteria 10.1142/s108842461750078x
Tolyporphins L-R: Unusual Tetrapyrroles from a Brasilonema sp. of Cyanobacterium. 10.1021/acs.joc.9b01928
6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2. 10.1021/acs.jnatprod.9b00844
Herbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10. 10.1021/np4006635
Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp. 10.1021/np100374b
Application of 1H-NMR metabolomic profiling for reef-building corals. 10.1371/journal.pone.0111274
Neopetrocyclamines A and B, polycyclic diamine alkaloids from the sponge Neopetrosia cf exigua. 10.1021/np500759r
Bromotyrosine-derived metabolites from an Indonesian marine sponge in the family Aplysinellidae (Order Verongiida). 10.1016/j.bmcl.2015.11.086
Classical and Alternative Activation of Cyanobacterium Oscillatoria sp. Lipopolysaccharide-Treated Rat Microglia in vitro. 10.1093/toxsci/kfv251
Pregnane-10,2-carbolactones from a Hawaiian Marine Sponge in the Genus Myrmekioderma. 10.1021/acs.jnatprod.6b00042
C-Glycosylflavones Alleviate Tau Phosphorylation and Amyloid Neurotoxicity through GSK3β Inhibition. 10.1021/acschemneuro.6b00059
15α-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models. 10.1158/1535-7163.mct-16-0291
Coordinated protein co-expression in plants by harnessing the synergy between an intein and a viral 2A peptide. 10.1111/pbi.12670
Myrmenaphthol A, Isolated from a Hawaiian Sponge of the Genus Myrmekioderma. 10.1021/acs.jnatprod.9b00665
Andreas Klitgaard
Klitgaard Andreas / Andreas Koefoed Klitgaard
ORCID: 0000-0002-2533-570X
Molecular and chemical characterization of the biosynthesis of the 6-MSA-derived meroterpenoid yanuthone D in Aspergillus niger 10.1016/j.chembiol.2014.01.013
Aggressive dereplication using UHPLC-DAD-QTOF: Screening extracts for up to 3000 fungal secondary metabolites 10.1007/s00216-013-7582-x
Accurate dereplication of bioactive secondary metabolites from marine-derived fungi by UHPLC-DAD-QTOFMS and a MS/HRMS library 10.3390/md12063681
Accurate prediction of secondary metabolite gene clusters in filamentous fungi 10.1073/pnas.1205532110
Combining Stable Isotope Labeling and Molecular Networking for Biosynthetic Pathway Characterization 10.1021/acs.analchem.5b01934
Combining UHPLC-High Resolution MS and Feeding of Stable Isotope Labeled Polyketide Intermediates for Linking Precursors to End Products 10.1021/np500979d
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria 10.1128/mSystems.00028-15
CRISPR-BEST: a highly efficient DSB-free base editor for filamentous actinomycetes 10.1101/582403
Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast 10.1016/j.synbio.2020.01.004
Tailored biosynthesis of gibberellin plant hormones in yeast 10.1016/j.ymben.2021.03.010
Mauricio Caraballo
Caraballo Mauricio / Mauricio Caraballo / Andres M Caraballo-Rodriguez
ORCID: 0000-0001-5499-2728
Amphotericin B as an inducer of griseofulvin-containing guttate in the endophytic fungus Xylaria cubensis FLe9 10.1007/s00049-017-0243-3
Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides 10.1038/s41598-017-05532-5
Expanding the Chemical Repertoire of the Endophyte Streptomyces albospinus RLe7 Reveals Amphotericin B as an Inducer of a Fungal Phenotype 10.1021/acs.jnatprod.6b00870
Endophytic Actinobacteria from the Brazilian Medicinal PlantLychnophora ericoidesMart. and the Biological Potential of Their Secondary Metabolites 10.1002/cbdv.201500225
Protocol for Community‐created Public MS/MS Reference Spectra Within the Global Natural Products Social Molecular Networking Infrastructure 10.1002/rcm.8725
Mass spectrometry searches using MASST 10.1038/s41587-019-0375-9
Cryptic Species Account for the Seemingly Idiosyncratic Secondary Metabolism of Sarcophyton glaucum Specimens Collected in Palau 10.1021/acs.jnatprod.9b01128
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 10.1038/s41587-019-0209-9
MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools 10.3390/metabo9070144
The extracellular matrix protects Bacillus subtilis colonies from Pseudomonas invasion and modulates plant co-colonization 10.1038/s41467-019-09944-x
Propagating annotations of molecular networks using in silico fragmentation 10.1371/journal.pcbi.1006089
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking 10.1038/nbt.3597
Wildlife-microbiome interactions and disease: exploring opportunities for disease mitigation across ecological scales 10.1016/j.ddmod.2019.08.012
Chemical signaling involved in plant–microbe interactions 10.1039/c7cs00343a
A Convolutional Neural Network-Based Approach for the Rapid Characterization of Molecularly Diverse Natural Products 10.1021/jacs.9b13786
Lars Jelsbak
Jelsbak Lars
ORCID: 0000-0002-5759-9769
Environmental heterogeneity drives within-host diversification and evolution of Pseudomonas aeruginosa 10.1128/mBio.01592-14
Within-host evolution of pseudomonas aeruginosa reveals adaptation toward iron acquisition from hemoglobin 10.1128/mBio.00966-14
Staphylococcus aureus alters growth activity, autolysis, and antibiotic tolerance in a human host-adapted Pseudomonas aeruginosa lineage 10.1128/JB.02006-14
Archetypal analysis of diverse Pseudomonas aeruginosa transcriptomes reveals adaptation in cystic fibrosis airways 10.1186/1471-2105-14-279
Genome Analysis of a Transmissible Lineage of Pseudomonas aeruginosa Reveals Pathoadaptive Mutations and Distinct Evolutionary Paths of Hypermutators 10.1371/journal.pgen.1003741
Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts 10.1073/pnas.1221466110
Typing of Pseudomonas aeruginosa from hemorrhagic pneumonia in mink (Neovison vison) 10.1016/j.vetmic.2012.12.003
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: An evolutionary perspective 10.1038/nrmicro2907
Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa 10.1128/AAC.00630-12
Deletion and acquisition of genomic content during early stage adaptation of Pseudomonas aeruginosa to a human host environment 10.1111/j.1462-2920.2012.02795.x
Multilocus sequence typing of total-genome-sequenced bacteria 10.1128/JCM.06094-11
Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection 10.1038/ismej.2011.83
Bacterial adaptation during chronic infection revealed by independent component analysis of transcriptomic data 10.1186/1471-2180-11-184
Microbial ecology and adaptation in cystic fibrosis airways 10.1111/j.1462-2920.2011.02459.x
Evolutionary dynamics of bacteria in a human host environment 10.1073/pnas.1018249108
Early adaptive developments of Pseudomonas aeruginosa after the transition from life in the environment to persistent colonization in the airways of human cystic fibrosis hosts 10.1111/j.1462-2920.2010.02211.x
In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections 10.1128/JB.01581-07
Comparative Genomics of Pseudomonas 10.1002/9783527622009.ch1
Complete genome sequence of the myxobacterium Sorangium cellulosum 10.1038/nbt1354
Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients 10.1128/IAI.01282-06
Enhancer-binding proteins with a forkhead-associated domain and the σ54 regulon in Myxococcus xanthus fruiting body development 10.1073/pnas.0409371102
σ54 enhancer binding proteins and Myxococcus xanthus fruiting body development 10.1128/JB.186.13.4361-4368.2004
Cell behavior and cell-cell communication during fruiting body morphogenesis in Myxococcus xanthus 10.1016/j.mimet.2003.08.007
Coupling gene expression and multicellular morphogenesis during fruiting body formation in Myxococcus xanthus 10.1046/j.1365-2958.2003.03399.x
Pattern formation by a cell surface-associated morphogen in Myxococcus xanthus 10.1073/pnas.042535699
Pattern formation: Fruiting body morphogenesis in Myxococcus xanthus 10.1016/S1369-5274(00)00153-3
The cell surface-associated intercellular C-signal induces behavioral changes in individual Myxococcus xanthus cells during fruiting body morphogenesis 10.1073/pnas.96.9.5031
Utilization and control of ecological interactions in polymicrobial infections and community-based microbial cell factories 10.12688/f1000research.7876.1
Application of WGS data for O-specific antigen analysis and in silico serotyping of Pseudomonas aeruginosa isolates 10.1128/JCM.00349-16
Substantial molecular evolution and mutation rates in prolonged latent Mycobacterium tuberculosis infection in humans 10.1016/j.ijmm.2016.05.017
A Bacteriophage-Acquired O-Antigen Polymerase (Wzyβ) from P. aeruginosa Serotype O16 Performs a Varied Mechanism Compared to Its Cognate Wzyα 10.3389/fmicb.2016.00393
The phenotypic evolution of Pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin 10.1099/mic.0.000273
Genome Sequence of Pseudomonas aeruginosa Strain DK1-NH57388A, a Stable Mucoid Cystic Fibrosis Isolate 10.1128/genomeA.00008-16
Evolution of metabolic divergence in Pseudomonas aeruginosa during long-term infection facilitates a proto-cooperative interspecies interaction 10.1038/ismej.2015.220
Antibiotic combination therapy can select for broad-spectrum multidrug resistance in Pseudomonas aeruginosa 10.1016/j.ijantimicag.2015.09.014
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium 10.3389/fmicb.2015.01036
The Widespread Multidrug-Resistant Serotype O12 Pseudomonas aeruginosa Clone Emerged through Concomitant Horizontal Transfer of Serotype Antigen and Antibiotic Resistance Gene Clusters. 10.1128/mBio.01396-15
Bacteriocin-mediated competition in cystic fibrosis lung infections 10.1098/rspb.2015.0972
Evolutionary insight from whole-genome sequencing of Pseudomonas aeruginosa from cystic fibrosis patients. 10.2217/fmb.15.3
Draft Genome Sequences of Pseudomonas aeruginosa B3 Strains Isolated from a Cystic Fibrosis Patient Undergoing Antibiotic Chemotherapy 10.1128/genomeA.00804-13
Biofilm as a production platform for heterologous production of rhamnolipids by the non-pathogenic strain Pseudomonas putida KT2440 10.1186/s12934-016-0581-9
Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis 10.1038/ncomms14631
Host adaptation mediated by intergenic evolution in a bacterial pathogen 10.1101/236000
Transcriptomic profiling of interacting nasal staphylococci species reveals global changes in gene and non-coding RNA expression 10.1093/femsle/fny004
SERS detection of the biomarker hydrogen cyanide from Pseudomonas aeruginosa cultures isolated from cystic fibrosis patients 10.1038/srep45264
Application of RNA-seq and Bioimaging Methods to Study Microbe-Microbe Interactions and Their Effects on Biofilm Formation and Gene Expression 10.1007/978-1-4939-7604-1_12
The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions 10.1038/ncomms13002
Genomic epidemiology of a major Mycobacterium tuberculosis outbreak: Retrospective cohort study in a low incidence setting using sparse time-series sampling 10.1093/infdis/jix298
Evolutionary dynamics of pseudomonas aeruginosa in CF 10.1002/ppul.22681
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking 10.1038/nbt.3597
A Major Mycobacterium tuberculosis outbreak caused by one specific genotype in a low-incidence country: Exploring gene profile virulence explanations 10.1038/s41598-018-30363-3
Intergenic evolution during host adaptation increases expression of the metallophore pseudopaline in Pseudomonas aeruginosa 10.1099/mic.0.000687
HldE Is Important for Virulence Phenotypes in Enterotoxigenic Escherichia coli 10.3389/fcimb.2018.00253
Complete Genome Sequence of a Bioactive Pseudomonas sp. Strain, DTU12.3, Isolated from Soil in Denmark 10.1128/MRA.00121-19
Within-Host Adaptation Mediated by Intergenic Evolution in Pseudomonas aeruginosa 10.1093/gbe/evz083
A Rare Thioquinolobactin Siderophore Present in a Bioactive Pseudomonas sp. DTU12.1 10.1093/gbe/evz267
Recurrent tuberculosis in patients infected with the predominant Mycobacterium tuberculosis outbreak strain in Denmark. New insights gained through whole genome sequencing 10.1016/j.meegid.2020.104169
Complete Genome Sequence of Pseudomonas sp. Strain SK, Isolated from Organic Wheat Rhizosphere 10.1128/MRA.00510-20
Development of a whole cell biosensor for detection of 2, 4-diacetylphloroglucinol-producing bacteria from grassland soil 10.1101/2020.06.23.168377
A Whole-Cell Biosensor for Detection of 2,4-Diacetylphloroglucinol (DAPG)-Producing Bacteria from Grassland Soil 10.1128/AEM.01400-20
The plasmidome of multidrug-resistant emergent Salmonella serovars isolated from poultry 10.1016/j.meegid.2021.104716
Identification and differentiation of Pseudomonas species in field samples using an rpoD amplicon sequencing methodology 10.1101/2021.06.08.447643
Identification and Differentiation of Pseudomonas Species in Field Samples Using an rpoD Amplicon Sequencing Methodology 10.1128/mSystems.00704-21
Anna Edlund
Edlund Anna
ORCID: 0000-0002-3394-4804
Discovery of a Novel Periodontal Disease-Associated Bacterium 10.1007/s00248-018-1200-6
Uncovering complex microbiome activities via metatranscriptomics during 24 hours of oral biofilm assembly and maturation 10.1186/s40168-018-0591-4
Establishing microbial composition measurement standards with reference frames. 10.1038/s41467-019-10656-5
Identification of the Bacterial Biosynthetic Gene Clusters of the Oral Microbiome Illuminates the Unexplored Social Language of Bacteria during Health and Disease. 10.1128/mBio.00321-19
Klebsiella and Providencia emerge as lone survivors following long-term starvation of oral microbiota. 10.1073/pnas.1820594116
Quorum Sensing Modulates the Epibiotic-Parasitic Relationship Between Actinomyces odontolyticus and Its Saccharibacteria epibiont, a Nanosynbacter lyticus Strain, TM7x. 10.3389/fmicb.2018.02049
Exploiting the Oral Microbiome to Prevent Tooth Decay: Has Evolution Already Provided the Best Tools? 10.3389/fmicb.2018.03323
Correction for Morton et al., "Uncovering the Horseshoe Effect in Microbial Analyses". 10.1128/mSystems.00006-18
Metabolic Fingerprints from the Human Oral Microbiome Reveal a Vast Knowledge Gap of Secreted Small Peptidic Molecules. 10.1128/mSystems.00058-17
Uncovering the Horseshoe Effect in Microbial Analyses. 10.1128/mSystems.00166-16
The Denture-Associated Oral Microbiome in Health and Stomatitis. 10.1128/mSphere.00215-16
Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen. 10.1128/mSystems.00139-16
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
Metagenome and Metatranscriptome Analyses Using Protein Family Profiles. 10.1371/journal.pcbi.1004991
High-Quality Draft Genome Sequence of Low-pH-Active Veillonella parvula Strain SHI-1, Isolated from Human Saliva within an In Vitro Oral Biofilm Model. 10.1128/genomeA.01684-15
Draft Genome Sequence of "Candidatus Bacteroides periocalifornicus," a New Member of the Bacteriodetes Phylum Found within the Oral Microbiome of Periodontitis Patients. 10.1128/genomeA.01485-15
Meta-omics uncover temporal regulation of pathways across oral microbiome genera during in vitro sugar metabolism. 10.1038/ismej.2015.72
Bacteria-mediated effects of antibiotics on Daphnia nutrition. 10.1021/acs.est.5b00833
Bacteriophage and their potential roles in the human oral cavity. 10.3402/jom.v7.27423
Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle. 10.1073/pnas.1419038112
An in vitro biofilm model system maintaining a highly reproducible species and metabolic diversity approaching that of the human oral microbiome. 10.1186/2049-2618-1-25
Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum. 10.1073/pnas.1219809110
Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform. 10.1101/gr.150433.112
Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. 10.1016/j.jprot.2012.05.036
Antibiotic-induced change of bacterial communities associated with the copepod Nitocra spinipes. 10.1371/journal.pone.0033107
Microdiversity and evidence for high dispersal rates in the marine actinomycete 'Salinispora pacifica'. 10.1111/j.1462-2920.2011.02641.x
Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola. 10.1128/AEM.00611-11
Use of bromodeoxyuridine immunocapture to identify psychrotolerant phenanthrene-degrading bacteria in phenanthrene-enriched polluted Baltic Sea sediments. 10.1111/j.1574-6941.2008.00513.x
Active bacterial community structure along vertical redox gradients in Baltic Sea sediment. 10.1111/j.1462-2920.2008.01624.x
Changes in active bacterial communities before and after dredging of highly polluted Baltic Sea sediments. 10.1128/AEM.00971-06
Microbial community structure in polluted Baltic Sea sediments. 10.1111/j.1462-2920.2005.00887.x
Cariogenic Streptococcus mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization 10.1021/acsinfecdis.9b00365
Caries-Associated Biosynthetic Gene Clusters in Streptococcus mutans 10.1177/0022034520914519
Commensal Oral Rothia mucilaginosa Produces Enterobactin, a Metal-Chelating Siderophore 10.1128/mSystems.00161-20
Composite Long- and Short-Read Sequencing Delivers a Complete Genome Sequence of B04Sm5, a Reutericyclin- and Mutanocyclin-Producing Strain of Streptococcus mutans 10.1128/MRA.01067-20
Deep metagenomics examines the oral microbiome during dental caries, revealing novel taxa and co-occurrences with host molecules 10.1101/gr.265645.120
The Oral Host–Microbial Interactome: An Ecological Chronometer of Health? 10.1016/j.tim.2020.11.004
A community resource for paired genomic and metabolomic data mining. 10.1038/s41589-020-00724-z
Bertrand Aigle
Aigle Bertrand
ORCID: 0000-0001-5266-5926
Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the spiramycin producer. 10.1016/j.jbiotec.2015.09.020
Minimum Information about a Biosynthetic Gene cluster. 10.1038/nchembio.1890
Identification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis. 10.1038/ncomms8674
Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction. 10.1039/c5cc01986a
Pseudomonas fluorescens pirates both ferrioxamine and ferricoelichelin siderophores from Streptomyces ambofaciens. 10.1128/AEM.03520-14
Gluconic acid-producing Pseudomonas sp. prevent γ-actinorhodin biosynthesis by Streptomyces coelicolor A3(2). 10.1007/s00203-014-1000-4
A single Sfp-type phosphopantetheinyl transferase plays a major role in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877. 10.1371/journal.pone.0087607
Genome mining of Streptomyces ambofaciens. 10.1007/s10295-013-1379-y
Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis. 10.1038/ja.2013.119
Actinomycetes: role in biotechnology and medicine. 10.1155/2013/687190
Volatile lactones from streptomycetes arise via the antimycin biosynthetic pathway. 10.1002/cbic.201200260
An unprecedented 1,2-shift in the biosynthesis of the 3-aminosalicylate moiety of antimycins. 10.1002/cbic.201200033
Waking up Streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors. 10.1016/B978-0-12-404634-4.00017-6
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. 10.1073/pnas.1019077108
Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of Kinamycins. 10.1128/JB.01269-10
A new data mining approach for the detection of bacterial promoters combining stochastic and combinatorial methods. 10.1089/cmb.2008.0122
Integrative gene cloning and expression system for Streptomyces sp. US 24 and Streptomyces sp. TN 58 bioactive molecule producing strains. 10.1155/2009/464986
Regulation of the synthesis of the angucyclinone antibiotic alpomycin in Streptomyces ambofaciens by the autoregulator receptor AlpZ and its specific ligand. 10.1128/JB.01989-07
SIGffRid: a tool to search for sigma factor binding sites in bacterial genomes using comparative approach and biologically driven statistics. 10.1186/1471-2105-9-73
Targeted Gene Disruption of the Cyclo (L-Phe, L-Pro) Biosynthetic Pathway in Streptomyces sp. US24 Strain. 10.1155/2007/91409
Evolution of the terminal regions of the Streptomyces linear chromosome. 10.1093/molbev/msl108
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens. 10.1128/JB.00734-06
Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens. 10.1128/JB.187.7.2491-2500.2005
Differential and cross-transcriptional control of duplicated genes encoding alternative sigma factors in Streptomyces ambofaciens. 10.1128/JB.186.16.5355-5365.2004
Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome. 10.1128/AAC.48.2.575-588.2004
End-to-end fusion of linear deleted chromosomes initiates a cycle of genome instability in Streptomyces ambofaciens. 10.1046/j.1365-2958.2003.03698.x
A single amino acid substitution in region 1.2 of the principal sigma factor of Streptomyces coelicolor A3(2) results in pleiotropic loss of antibiotic production. 10.1046/j.1365-2958.2000.02022.x
Characterization of two Streptomyces ambofaciens recA mutants: identification of the RecA protein by immunoblotting. 10.1016/S0378-1097(97)00073-6
Expression of the Streptomyces coelicolor A3(2) ptpA gene encoding a phosphotyrosine protein phosphatase leads to overproduction of secondary metabolites in S. lividans. 10.1016/0378-1097(96)00359-X
Comparative Genomics among Closely Related Streptomyces Strains Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity. 10.3390/antibiotics7040086
Draft Whole-Genome Shotgun Sequence of Streptomyces sp. Strain ETH9427. 10.1128/MRA.01197-18
Diversity and antimicrobial activities of Streptomyces isolates from Fetzara Lake, north eastern Algeria. 10.1684/abc.2017.1316
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
Role of secondary metabolites in the interaction between Pseudomonas fluorescens and soil microorganisms under iron-limited conditions. 10.1093/femsec/fiw107
N-acylation of L-amino acids in aqueous media: Evaluation of the catalytic performances of Streptomyces ambofaciens aminoacylases 10.1016/j.enzmictec.2020.109536
Molecular Dynamics to Elucidate the DNA-Binding Activity of AlpZ, a Member of the Gamma-Butyrolactone Receptor Family in Streptomyces ambofaciens. 10.3389/fmicb.2020.01255
Inhibitions Dominate but Stimulations and Growth Rescues Are Not Rare Among Bacterial Isolates from Grains of Forest Soil. 10.1007/s00248-020-01579-6
An aminoacylase activity from Streptomyces ambofaciens catalyzes the acylation of lysine on α-position and peptides on N-terminal position. 10.1002/elsc.201700173
Bacterial genome mining for novel natural product discovery 10.1055/s-0032-1320194
Isolation and characterization of a mutator strain of Streptomyces ambofaciens ATCC23877 exhibiting an increased level of genetic instability 10.1139/m96-076
Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation 10.1101/2020.12.09.415976
Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation 10.21203/rs.3.rs-145840/v1
Successes, surprises and pitfalls in modular polyketide synthase engineering: generation of ring-contracted stambomycins 10.21203/rs.3.rs-222743/v1
Towards the sustainable discovery and development of new antibiotics 10.1038/s41570-021-00313-1
Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation 10.1038/s41467-021-25462-1
Roger Linington
Linington Roger / Roger G. Linington
ORCID: 0000-0003-1818-4971
Biofilm Formation and Detachment in Gram-Negative Pathogens Is Modulated by Select Bile Acids. 10.1371/journal.pone.0149603
The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes. 10.1074/jbc.M115.673210
Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries. 10.1073/pnas.1507743112
Phenotype-Guided Natural Products Discovery Using Cytological Profiling. 10.1021/acs.jnatprod.5b00455
Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. 10.1021/acschembio.5b00308
Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. 10.1021/acs.joc.5b01264
Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms. 10.1039/c5ob01134e
Living in the matrix: assembly and control of Vibrio cholerae biofilms. 10.1038/nrmicro3433
Connecting phenotype and chemotype: high-content discovery strategies for natural products research. 10.1021/acs.jnatprod.5b00017
Salinipostins A-K, long-chain bicyclic phosphotriesters as a potent and selective antimalarial chemotype. 10.1021/jo5024409
Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism. 10.1021/ol503349y
Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae. 10.1039/c4cc07003h
Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis. 10.1021/np500727g
A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. 10.1016/j.cell.2014.08.032
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. 10.1016/j.cell.2014.06.034
Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity. 10.1371/journal.pone.0084549
An NF-κB-based high-throughput screen identifies piericidins as inhibitors of the Yersinia pseudotuberculosis type III secretion system. 10.1128/AAC.02025-13
Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa. 10.1128/AAC.01781-13
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. 10.1038/ja.2013.99
Discovery and biological characterization of the auromomycin chromophore as an inhibitor of biofilm formation in Vibrio cholerae. 10.1002/cbic.201300131
Molecular networking as a dereplication strategy. 10.1021/np400413s
Mechanism of action-based classification of antibiotics using high-content bacterial image analysis. 10.1039/c3mb70027e
Development of quinoline-based disruptors of biofilm formation against Vibrio cholerae. 10.1021/ol400150z
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. 10.1021/np300834q
"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening. 10.1016/j.chembiol.2012.12.007
Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics. 10.1016/j.chembiol.2012.09.014
Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP. 10.1016/j.chembiol.2012.08.014
Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness. 10.1371/journal.pone.0046172
Chemical inhibitors of the type three secretion system: disarming bacterial pathogens. 10.1128/AAC.00975-12
Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products. 10.1371/journal.pone.0035398
Total synthesis, stereochemical assignment, and antimalarial activity of gallinamide A. 10.1002/chem.201102538
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. 10.1038/nchembio.664
Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants. 10.1016/j.bmc.2011.07.017
Versatile method for the detection of covalently bound substrates on solid supports by DART mass spectrometry. 10.1021/ol201404v
Expedient synthesis of α,α-dimethyl-β-hydroxy carbonyl scaffolds via Evans' aldol reaction with a tertiary enolate. 10.1016/j.tetlet.2011.03.126
An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae. 10.1039/c0mb00276c
Identification and characterization of a phosphodiesterase that inversely regulates motility and biofilm formation in Vibrio cholerae. 10.1128/JB.00209-10
Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. 10.1021/jm100265s
Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity. 10.1021/np900622m
Dereplication and de novo sequencing of nonribosomal peptides. 10.1038/nmeth.1350
New innovations for an old infection: antimalarial lead discovery from marine natural products during the period 2003-2008. 10.4155/fmc.09.56
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. 10.1021/ac900114t
Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. 10.1021/np8003529
Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp. 10.1021/np070280x
Linking bioprospecting with sustainable development and conservation: the Panama case 10.1007/s10531-007-9214-2
Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. 10.1021/np0700772
Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp. 10.1021/np0605790
Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia. 10.1021/np050192h
Stereochemical assignment in acyclic lipids across long distance by circular dichroism: absolute stereochemistry of the aglycone of caminoside A. 10.1002/anie.200461158
Latonduines A and B, new alkaloids isolated from the marine sponge Stylissa carteri: structure elucidation, synthesis, and biogenetic implications. 10.1021/ol034950b
Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia. 10.1021/ol0268337
Total Synthesis of Glycinocins A-C. 10.1021/acs.joc.7b01959
Total Synthesis of Skyllamycins A-C. 10.1002/chem.201704277
Data-analysis strategies for image-based cell profiling. 10.1038/nmeth.4397
Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high. 10.1073/pnas.1711139114
Retrospective analysis of natural products provides insights for future discovery trends. 10.1073/pnas.1614680114
Special Issue in Honor of Professor Phil Crews. 10.1021/acs.jnatprod.7b00161
Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. 10.1038/ncomms14414
Piericidin A1 Blocks Yersinia Ysc Type III Secretion System Needle Assembly. 10.1128/msphere.00030-17
Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure-activity relationship of anabaenopeptin protease inhibitors. 10.1016/j.bmcl.2016.09.008
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
Erratum for Duncan et al., An NF-κB-Based High-Throughput Screen Identifies Piericidins as Inhibitors of the Yersinia pseudotuberculosis Type III Secretion System. 10.1128/aac.00973-16
Image-Based Screening Approaches to Natural Products Discovery 10.1002/9781118794623.ch20
De Novo Sequencing of Nonribosomal Peptides 10.1007/978-3-540-78839-3_16
De Novo terpenoid biosynthesis by the dendronotid nudibranch Melibe leonina 10.1007/pl00012669
The bioactive lipid (S)-sebastenoic acid impacts motility and dispersion in Vibrio cholerae 10.1139/cjc-2017-0334
Synthetic Studies Toward the Skyllamycins: Total Synthesis and Generation of Simplified Analogues 10.1021/acs.joc.8b00898
Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile. 10.1021/acsinfecdis.7b00105
A selective genome-guided method for environmental Burkholderia isolation. 10.1007/s10295-018-02121-x
Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source. 10.1002/anie.201805673
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. 10.1039/c7np00064b
Synthesis and evaluation of analogues of the glycinocin family of calcium-dependent antibiotics. 10.1039/c8ob01268g
Maculatic Acids-Sex Attractant Pheromone Components of Bald-Faced Hornets. 10.1002/anie.201804666
Cutibacterium acnes antibiotic production shapes niche competition in the human skin microbiome 10.1101/594010
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. 10.1039/c8np90041h
Problems in Organic Structure Determination 10.1201/b19329
MIBiG 2.0: a repository for biosynthetic gene clusters of known function 10.1093/nar/gkz882
High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling 10.1101/748129
Isolation, Structure Elucidation, and Total Synthesis of Dolichovespulide, a Sesquiterpene from Dolichovespula Yellowjackets 10.1021/acs.jnatprod.9b00238
Targeting tRNA-Synthetase Interactions towards Novel Therapeutic Discovery Against Eukaryotic Pathogens 10.1101/711697
New methods for isolation and structure determination of natural products 10.1039/c9np90023c
Development of a Custom MALDI-TOF Mass Spectrometric Database for Identification of Environmental Burkholderia and Related Genera. 10.1128/aem.00354-20
Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens. 10.1371/journal.pntd.0007983
The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites. 10.1016/j.chembiol.2020.01.001
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery. 10.1021/acscentsci.9b00806
A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles 10.1126/scitranslmed.aay5445
Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products. 10.1021/acschembio.0c00824
Microbial natural product databases: moving forward in the multi-omics era. 10.1039/d0np00053a
Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran