A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products
Raphael Reher Hyun Woo Kim Chen Zhang Huanru Henry Mao Mingxun Wang Louis-Félix Nothias Andres Mauricio Caraballo-Rodriguez Evgenia Glukhov Bahar Teke Tiago Leao Kelsey L. Alexander Brendan M. Duggan Ezra L. Van Everbroeck Pieter C. Dorrestein Garrison W. Cottrell William H. Gerwick
Raphael Reher
Reher Raphael
ORCID: 0000-0002-5858-1173
A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria 10.3390/md19010020
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Heterologous Expression of Cryptomaldamide in a Cyanobacterial Host 10.1021/acssynbio.0c00431
Cell‐permeable high‐affinity tracers for G q proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors 10.1111/bph.14960
A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products 10.1021/jacs.9b13786
A community resource for paired genomic and metabolomic data mining 10.1038/s41589-020-00724-z
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain 10.1021/acs.jmedchem.9b00294
Structural and Dynamical Basis of G Protein Inhibition by YM-254890 and FR900359: An Inhibitor in Action 10.1021/acs.jcim.9b00433
Direct targeting of Gαq and Gα11 oncoproteins in cancer cells 10.1126/scisignal.aau5948
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Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq‐Signaling Inhibitor FR900359 10.1002/anie.201707996
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The genome analysis of C andidatus  Burkholderia crenata reveals that secondary metabolism may be a key function of the A rdisia crenata leaf nodule symbiosis 10.1111/1462-2920.13184
Brendan Duggan
Duggan Brendan / Brendan M. Duggan
ORCID: 0000-0002-7034-8374
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Ultra-high resolution band-selective HSQC for nanomole-scale identification of chlorine-substituted13C in natural products drug discovery 10.1002/mrc.4415
A Distal Mutation Perturbs Dynamic Amino Acid Networks in Dihydrofolate Reductase 10.1021/bi400563c
Detailed Analysis of (−)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists 10.1021/np500644k
Conformational dynamics of thyroid hormones by variable temperature nuclear magnetic resonance: The role of side chain rotations and cisoid/transoid interconversions 10.1021/jm9606610
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1 H and 13 C NMR Relaxation Studies of Molecular Dynamics of the Thyroid Hormones Thyroxine, 3,5,3‘-Triiodothyronine, and 3,5-Diiodothyronine † 10.1021/jm960231+
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Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria 10.1021/acs.jnatprod.5b00301
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Identification of a 3-alkylpyridinium compound from the red sea sponge Amphimedon chloros with in vitro inhibitory activity against the West Nile Virus NS3 protease 10.3390/molecules23061472
Toward Expanded Diversity of Host–Guest Interactions via Synthesis and Characterization of Cyclodextrin Derivatives 10.1007/s10953-018-0769-1
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The Pierced Lasso Topology Leptin has a Bolt on Dynamic Domain Composed by the Disordered Loops I and III 10.1016/j.jmb.2020.01.035
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-020-60108-0
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Experimental characterization of the association of β-cyclodextrin and eight novel cyclodextrin derivatives with two guest compounds 10.1007/s10822-020-00350-w
A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products 10.1021/jacs.9b13786
Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties 10.1021/acschembio.9b00992
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Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for α7 nAChRs 10.1021/acs.jmedchem.9b01467
Chen Zhang
Zhang Chen
ORCID: 0000-0003-4805-0392
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Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-017-13923-x
Dual-Functionalized Theranostic Nanocarriers 10.1021/acsami.6b02761
Synthesis of nano-bowls with a Janus template 10.1039/c4nr05153j
Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing 10.1039/c6nr02445a
Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta 10.1021/acs.joc.5b01264
Designing hollow nano gold golf balls 10.1021/am502519x
Carboxylated nanodiamonds inhibit γ-irradiation damage of human red blood cells 10.1039/c5nr06789h
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The Samholides, Swinholide Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp. 10.1021/acs.joc.8b00028
Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, Derbesia sp., Using MS/MS-Based Molecular Networking 10.1021/acs.jnatprod.9b01019
A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products 10.1021/jacs.9b13786
Author Correction: Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-020-60108-0
Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A 10.1021/acs.jnatprod.0c01317
Garrison Cottrell
Cottrell Garrison
ORCID: 0000-0001-7538-1715
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A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products 10.1021/jacs.9b13786
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Mauricio Caraballo
Caraballo Mauricio / Mauricio Caraballo / Andres M Caraballo-Rodriguez
ORCID: 0000-0001-5499-2728
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Expanding the Chemical Repertoire of the Endophyte Streptomyces albospinus RLe7 Reveals Amphotericin B as an Inducer of a Fungal Phenotype 10.1021/acs.jnatprod.6b00870
Endophytic Actinobacteria from the Brazilian Medicinal PlantLychnophora ericoidesMart. and the Biological Potential of Their Secondary Metabolites 10.1002/cbdv.201500225
Protocol for Community‐created Public MS/MS Reference Spectra Within the Global Natural Products Social Molecular Networking Infrastructure 10.1002/rcm.8725
Mass spectrometry searches using MASST 10.1038/s41587-019-0375-9
Cryptic Species Account for the Seemingly Idiosyncratic Secondary Metabolism of Sarcophyton glaucum Specimens Collected in Palau 10.1021/acs.jnatprod.9b01128
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 10.1038/s41587-019-0209-9
MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools 10.3390/metabo9070144
The extracellular matrix protects Bacillus subtilis colonies from Pseudomonas invasion and modulates plant co-colonization 10.1038/s41467-019-09944-x
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Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking 10.1038/nbt.3597
Wildlife-microbiome interactions and disease: exploring opportunities for disease mitigation across ecological scales 10.1016/j.ddmod.2019.08.012
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A Convolutional Neural Network-Based Approach for the Rapid Characterization of Molecularly Diverse Natural Products 10.1021/jacs.9b13786