Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species
Naman, C. Benjamin Almaliti, Jehad Armstrong, Lorene Caro-Diaz, Eduardo J. Pierce, Marsha L. Glukhov, Evgenia Fenner, Amanda Spadafora, Carmenza Debonsi, Hosana M. Dorrestein, Pieter C. Murray, Thomas F. Gerwick, William H.
C. Benjamin Naman
Naman C. Benjamin
ORCID: 0000-0002-4361-506X
Computer-Assisted Structure Elucidation of Black Chokeberry (Aronia melanocarpa) Fruit Juice Isolates with a New Fused Pentacyclic Flavonoid Skeleton. 10.1021/acs.orglett.5b01284
Northalrugosidine is a bisbenzyltetrahydroisoquinoline alkaloid from Thalictrum alpinum with in vivo antileishmanial activity. 10.1021/np501028u
Pyrrole alkaloids with potential cancer chemopreventive activity isolated from a goji berry-contaminated commercial sample of African mango. 10.1021/jf500802x
Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum. 10.1021/acs.jnatprod.5b01131
A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani. 10.1021/acsinfecdis.5b00081
Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. 10.1021/acs.jnatprod.6b00907
Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata. 10.3390/md15040121
Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products. 10.1007/s13205-017-0610-3
Preparative Separation and Purification of Trichothecene Mycotoxins from the Marine Fungus Fusarium sp. LS68 by High-Speed Countercurrent Chromatography in Stepwise Elution Mode 10.3390/md16020073
5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro. 10.3390/molecules22101651
Bioassay-Guided Isolation of Antioxidant and Cytoprotective Constituents from a Maqui Berry (Aristotelia chilensis) Dietary Supplement Ingredient As Markers for Qualitative and Quantitative Analysis. 10.1021/acs.jafc.7b03261
5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34. 10.3390/md15080260
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. 10.1021/acs.jnatprod.7b00367
MetaRiPPquest: A Peptidogenomics Approach for the Discovery of Ribosomally Synthesized and Post-translationally Modified Peptides 10.1101/227504
Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β. 10.1021/acschemneuro.7b00527
Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States. 10.1016/j.jtcme.2018.01.006
Phytodrugs and Immunomodulators for the Therapy of Leishmaniasis 10.1016/b978-0-08-102081-4.00009-5
Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation 10.1016/b978-0-12-804765-1.00005-9
Pharmaceuticals, Plant Drugs 10.1016/b978-0-12-394807-6.00163-5
DNA Binding and Molecular Dynamic Studies of Polycyclic Tetramate Macrolactams (PTM) with Potential Anticancer Activity Isolated from a Sponge-Associated Streptomyces zhaozhouensis subsp. mycale subsp. nov. 10.1007/s10126-018-9866-9
Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice. 10.3389/fncel.2018.00396
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents. 10.1016/j.ejmech.2018.10.024
A new lateral root growth inhibitor from the sponge-derived fungus Aspergillus sp. LS45 10.1016/j.bmcl.2019.04.051
9-Methylfascaplysin Is a More Potent Aβ Aggregation Inhibitor than the Marine-Derived Alkaloid, Fascaplysin, and Produces Nanomolar Neuroprotective Effects in SH-SY5Y Cells. 10.3390/md17020121
25C-NBOMe, a Novel Designer Psychedelic, Induces Neurotoxicity 50 Times More Potent Than Methamphetamine In Vitro. 10.1007/s12640-019-0012-x
Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca2+-ATPase. 10.1016/j.fitote.2019.04.005
A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors. 10.3390/md17090493
Isolation and Analysis of Antioxidant Phytochemicals from Black Chokeberry, Maqui, and Goji Berry Dietary Supplements 10.1021/bk-2018-1286.ch001
Investigation of Vietnamese plants for potential anticancer agents 10.1007/s11101-014-9335-7
Phthalideisoquinoline Hemiacetal Alkaloids from Corydalis decumbens That Inhibit Spontaneous Calcium Oscillations, including Alkyl Derivatives of (+)-Egenine That Are Strikingly Levorotatory 10.1021/acs.jnatprod.9b00247
Prospects of multitarget drug designing strategies by linking molecular docking and molecular dynamics to explore the protein–ligand recognition process 10.1002/ddr.21673
Three New Diketopiperazines from the Previously Uncultivable Marine Bacterium Gallaecimonas mangrovi HK-28 Cultivated by iChip. 10.1002/cbdv.202000221
MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. 10.1016/j.cels.2019.09.004
New Dihydroisocoumarin Root Growth Inhibitors From the Sponge-Derived Fungus Aspergillus sp. NBUF87. 10.3389/fmicb.2019.02846
Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties. 10.1021/acschembio.9b00992
The Chemistry, Biochemistry and Pharmacology of Marine Natural Products from Leptolyngbya, a Chemically Endowed Genus of Cyanobacteria 10.3390/md18100508
Applying a Chemogeographic Strategy for Natural Product Discovery from the Marine Cyanobacterium Moorena bouillonii 10.3390/md18100515
Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy 10.3390/ijms22052408
Metabolomic Characterization of a cf. Neolyngbya Cyanobacterium from the South China Sea Reveals Wenchangamide A, a Lipopeptide with In Vitro Apoptotic Potential in Colon Cancer Cells 10.3390/md19070397
Marsha Pierce
Pierce Marsha
ORCID: 0000-0002-7265-0104
A Comparison of the Ability of Leu8- and Pro8-Oxytocin to Regulate Intracellular Ca2+ and Ca2+-Activated K+ Channels at Human and Marmoset Oxytocin Receptors. 10.1124/mol.118.114744
Sensational MicroRNAs: Neurosensory Roles of the MicroRNA-183 Family 10.1007/s12035-019-01717-3
Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, Derbesia sp., Using MS/MS-Based Molecular Networking 10.1021/acs.jnatprod.9b01019
Comparison of the pharmacologic profiles of arginine vasopressin and oxytocin analogs at marmoset, titi monkey, macaque, and human oxytocin receptors 10.1016/j.biopha.2020.109832
Conditional deletion of the human ortholog gene Dicer1 in Pax2-Cre expression domain impairs orofacial development 10.4103/0971-6866.107984
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367
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Comparison of the pharmacological profiles of arginine vasopressin and oxytocin analogs at marmoset, macaque, and human vasopressin 1a receptor 10.1016/j.biopha.2020.110060
Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke 10.3390/md18070374
Treating Traumatic Brain Injuries with Electroceuticals: Implications for the Neuroanatomy of Consciousness 10.3390/neurosci2030018
Carmenza Spadafora
Spadafora Carmenza
ORCID: 0000-0002-3002-9467
Email: cspadafora@indicasat.org.pa
Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf.Trichodesmiumsp. nov. 10.1021/np200611f
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Cytotoxic Veraguamides, Alkynyl Bromide-Containing Cyclic Depsipeptides from the Marine Cyanobacterium cf.Oscillatoria margaritifera 10.1021/np200077f
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Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice 10.1080/13880209.2016.1181659
Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine CyanobacteriumOkeania hirsuta 10.1021/acs.joc.5b01264
Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives 10.1038/s41598-017-12336-0
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Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group 10.1021/acs.jnatprod.7b00917
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367
Evaluation of antiparasitic, anticancer, antimicrobial and hypoglycemic properties of organic extracts from Panamanian mangrove plants 10.4103/1995-7645.223531
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Revisión de Modelos Hiperelásticos utilizados en Tejidos 10.18502/keg.v3i1.1417
jehad almaliti
almaliti jehad
ORCID: 0000-0002-3562-0846
Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel 10.1016/j.chembiol.2016.04.008
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria 10.1021/acs.jnatprod.5b00301
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Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367
20S proteasome as a drug target in Trichomonas vaginalis 10.1128/AAC.00448-19
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Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents 10.1016/j.ejmech.2018.10.024
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain 10.1021/acs.jmedchem.9b00294
Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue 10.1021/acs.jmedchem.6b01271
Lorene Armstrong
Armstrong Lorene
ORCID: 0000-0003-4078-8990
Morpho-anatomy of the leaf and stem of Eugenia pyriformis 10.1590/S0102-695X2012005000022
Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium 10.1021/acsjnatprod.6600907
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367
Molecular networking prospection and characterization of terpenoids and C15-acetogenins in Brazilian seaweed extracts 10.1039/c8ra02802h
Lamium Plants—A Comprehensive Review on Health Benefits and Biological Activities 10.3390/molecules24101913
Chemistry and Biological Activities of Processed Camellia sinensis Teas: A Comprehensive Review 10.1111/1541-4337.12479
A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors 10.3390/md17090493
Allicin and health: A comprehensive review 10.1016/j.tifs.2019.03.003
Volatile Compounds Produced by Cyanobacteria Isolated from Mangrove Environment 10.1007/s00284-019-01658-z
In vitro effects of Eugenia pyriformis Cambess., Myrtaceae: Antimicrobial activity and synergistic interactions with Vancomycin and Fluconazole 10.5897/ajpp2014.4100
Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium 10.1021/acs.jnatprod.6b00907
Anacardium Plants: Chemical,Nutritional Composition and Biotechnological Applications 10.3390/biom9090465
Antitumor Potential of Seaweed Derived-Endophytic Fungi 10.3390/antibiotics8040205
Novel marine cyanobacteria from the Atlantic coast of Brazil 10.1080/26388081.2020.1753571