Paperbase

William Gerwick

Gerwick William

ORCID: 0000-0003-1403-4458

Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata 10.3390/md15040121

Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group 10.3390/md16050163

Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease 10.3390/molecules23061472

MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria 10.3390/md16120505

Integrated Genomic and Metabolomic Approach to the Discovery of Potential Anti-Quorum Sensing Natural Products from Microbes Associated with Marine Samples from Singapore 10.3390/md17010072

Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke 10.3390/md18070374

A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria 10.3390/md19010020

Kalkitoxin Reduces Osteoclast Formation and Resorption and Protects against Inflammatory Bone Loss 10.3390/ijms22052303

Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034

Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity 10.1021/acs.jmedchem.7b00671

5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34 10.3390/md15080260

The Face of a Molecule 10.1021/acs.jnatprod.7b00624

Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-017-13923-x

A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit 10.1021/acschembio.7b00746

Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group 10.1021/acs.jnatprod.7b00917

Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp. 10.1021/acs.joc.8b00028

Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β 10.1021/acschemneuro.7b00527

Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module 10.1021/acschembio.8b00252

Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta 10.1021/acschembio.8b00910

Structural Basis of Polyketide Synthase O-Methylation 10.1021/acschembio.8b00687

Dragocins A−D, Structurally Intriguing Cytotoxic Metabolites from a Panamanian Marine Cyanobacterium 10.1021/acs.orglett.8b03712

Marine natural products as potential anti-tubercular agents 10.1016/j.ejmech.2019.01.026

Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp. 10.1021/acs.orglett.8b04050

Nature's Combinatorial Biosynthesis Produces Vatiamides A–F 10.1002/anie.201902571

Nature's Combinatorial Biosynthesis Produces Vatiamides A–F 10.1002/ange.201902571

Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.9b00549

Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain 10.1021/acs.jmedchem.9b00294

Commensal oralRothia mucilaginosaproduces enterobactin – a metal chelating siderophore 10.1101/2020.02.20.956391

Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity 10.3390/molecules25071604

Commensal Oral Rothia mucilaginosa Produces Enterobactin, a Metal-Chelating Siderophore 10.1128/mSystems.00161-20

Correction to “Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp.” 10.1021/acs.orglett.0c02252

The Chemistry, Biochemistry and Pharmacology of Marine Natural Products from Leptolyngbya, a Chemically Endowed Genus of Cyanobacteria 10.3390/md18100508

Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2 10.1021/acs.jnatprod.0c00968

Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A 10.1021/acs.jnatprod.0c01317

Cyanobacteria-shrimp colonies in the Mariana Islands 10.1007/s10452-021-09837-6

Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium 10.1021/acs.jnatprod.0c01383

SIRT1 Activation Enhancing 8,3′-Neolignans from the Twigs of Corylopsis coreana Uyeki 10.3390/plants10081684

First Total Synthesis and Structure–Activity Relationship of Iheyamide A, an Antitrypanosomal Linear Peptide Isolated from a Dapis sp. Marine Cyanobacterium 10.1021/acs.jnatprod.1c00792

Carmenza Spadafora

Spadafora Carmenza

ORCID: 0000-0002-3002-9467

Email: cspadafora@indicasat.org.pa

Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf.Trichodesmiumsp. nov. 10.1021/np200611f

Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus 10.1016/j.tetlet.2011.12.021

Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins 10.1021/ol301607q

Antitrypanosomal alkaloids from the marine bacterium Bacillus pumilus 10.3390/molecules170911146

Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes 10.1016/j.molbiopara.2011.01.005

Cytotoxic Veraguamides, Alkynyl Bromide-Containing Cyclic Depsipeptides from the Marine Cyanobacterium cf.Oscillatoria margaritifera 10.1021/np200077f

Comparison of the in vitro invasive capabilities of Plasmodium falciparum schizonts isolated by Percoll gradient or using magnetic based separation 10.1186/1475-2875-10-96

Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum 10.1371/journal.ppat.1000968

Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity 10.1371/journal.pone.0084549

Erratum: Anti-malarial activity and HS-SPME-GC-MS chemical profiling of Plinia cerrocampanensis leaf essential oil (Malaria Journal (2014) 13 (235)) 10.1186/1475-2875-13-235

Chemical and bioactive natural products from microthyriaceae sp., an endophytic fungus from a tropical grass 10.1111/lam.12245

Malarial hemozoin: From target to tool 10.1016/j.bbagen.2014.02.009 Review

Bioactivity of Fungal Endophytes as a Function of Endophyte Taxonomy and the Taxonomy and Distribution of Their Host Plants 10.1371/journal.pone.0073192

Randomized, double-blinded, phase 2 trial of wr 279,396 (paromomycin and gentamicin) for cutaneous leishmaniasis in panama 10.4269/ajtmh.12-0736

Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi 10.2436/20.1501.01.139

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi 10.1016/S0166-6851(02)00156-1

Blood Stage Plasmodium falciparum Exhibits Biological Responses to Direct Current Electric Fields 10.1371/journal.pone.0161207

Volatile organic compounds associated with Plasmodium falciparum infection in vitro 10.1186/s13071-017-2157-x

Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants 10.1038/s41598-017-05515-6

Phytochemical composition, antiparasitic and α–glucosidase inhibition activities from Pelliciera rhizophorae 10.1186/s13065-015-0130-3

Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β-Amino Acids 10.1021/acs.orglett.5b03110

Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034

Malarial hemozoin: From target to tool 10.1016/j.bbagen.2014.02.009

Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice 10.1080/13880209.2016.1181659

Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine CyanobacteriumOkeania hirsuta 10.1021/acs.joc.5b01264

Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives 10.1038/s41598-017-12336-0

Pumilacidins from the octocoral-associated bacillus sp. Dt001 display anti-proliferative effects in plasmodium falciparum 10.3390/molecules23092179

Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro 10.1038/s41598-019-41697-x

Antiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected mice 10.1007/s12639-020-01207-7

Author Correction: Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro 10.1038/s41598-020-69582-y

Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi 10.3390/molecules26144217

Secondary metabolites from Panamanian mat forming cyanobacteria 10.1055/s-0032-1320708

Access and Benefit Sharing Under the Nagoya Protocol—Quo Vadis? Six Latin American Case Studies Assessing Opportunities and Risk 10.3389/fphar.2020.00765

Semisynthesis, Antiplasmodial Activity, and Mechanism of Action Studies of Isocoumarin Derivatives 10.1021/acs.jnatprod.0c01032

Extracellular Vesicles Could Carry an Evolutionary Footprint in Interkingdom Communication 10.3389/fcimb.2020.00076

Correction: Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity (PLoS ONE) 10.1371/annotation/10c47668-8c49-48d2-ba65-60420af463b6

Thermo-Energetic Study in Blood Infected with Plasmodium falciparum radiated at 2.45GHz 10.23919/EuMC.2019.8910930

Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group 10.1021/acs.jnatprod.7b00917

Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367

Evaluation of antiparasitic, anticancer, antimicrobial and hypoglycemic properties of organic extracts from Panamanian mangrove plants 10.4103/1995-7645.223531

Antiparasitic compounds from the panamanian marine bacterium pseudomonas aeruginosa 10.1177/1934578X1901400109

19-Hydroxy-bufalin, a major bufadienolide isolated from the parotoid gland secretions of the Panamanian endemic toad Rhinella centralis (Bufonidae), inhibits the growth of Trypanosoma cruzi 10.1016/j.toxicon.2020.02.009

Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién 10.1371/journal.pone.0214193

Revisión de Modelos Hiperelásticos utilizados en Tejidos 10.18502/keg.v3i1.1417

Marcelino Gutierrez

Gutierrez Marcelino

ORCID: 0000-0003-1423-3772

Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea 10.3390/molecules21060819

Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants 10.1038/s41598-017-05515-6

Antimicrobial‐producing Pseudoalteromonas from the marine environment of Panama shows a high phylogenetic diversity and clonal structure 10.1002/jobm.201800087

Imaging Mass Spectrometry of a Coral Microbe Interaction with Fungi 10.1007/s10886-013-0320-1

Leptolide, a new furanocembranolide diterpene from Leptogorgia alba 10.1021/np049745z

Cannabinomimetic lipid from a marine cyanobacterium 10.1021/np200610t

Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula 10.1021/jo900578j

Antiprotozoal activity against Plasmodium falciparum and Trypanosoma cruzi of aeroplysinin-1 isolated from the new sponge Aplysina chiriquensis 10.1080/13880200500406503

Antiplasmodial activity of bacilosarcin A isolated from the octocoral-associated bacterium Bacillus sp. collected in Panama 10.4103/0975-7406.92739

Antitrypanosomal alkaloids from the marine bacterium Bacillus pumilus 10.3390/molecules170911146

L-Galactose as a natural product: Isolation from a marine octocoral of the first α-L-galactosyl saponin 10.1016/j.tetlet.2004.08.170

MS/MS networking guided analysis of molecule and gene cluster families 10.1073/pnas.1303471110

Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new Guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida 10.1021/np800121a

seco-briarellinone and briarellin S, two new eunicellin-based diterpenoids from the panamanian octocoral Briareum asbestinum 10.3390/md10112608

Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034

Antiplasmodial metabolites isolated from the marine octocoral Muricea austera 10.1021/np060007f

A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages 10.1371/journal.pone.0084107

Microbiota of healthy corals are active against fungi in a light-dependent manner 10.1021/cb500432j

Toxins and pharmacologically active compounds from species of the family Bufonidae (Amphibia, Anura) 10.1016/j.jep.2016.12.021

Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides 10.1021/ac900114t

Malyngolide dimer, a bioactive symmetric cyclodepside from the panamanian marine cyanobacterium lyngbya majuscula 10.1021/np9005184

Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-β Aggregation in Alzheimer's Disease 10.3233/JAD-170071

Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum 10.3390/molecules23092179

A Marine Diterpenoid Modulates the Proteasome Activity in Murine Macrophages Stimulated with LPS 10.3390/biom8040109

Viscosin-like lipopeptides from frog skin bacteria inhibit Aspergillus fumigatus and Batrachochytrium dendrobatidis detected by imaging mass spectrometry and molecular networking 10.1038/s41598-019-39583-7

Antiparasitic Compounds from the Panamanian Marine Bacterium Pseudomonas aeruginosa https://doi.org/10.1177/1934578X1901400109

Fungus-Growing Ant’s Microbial Interaction of Streptomyces sp. and Escovopsis sp. through Molecular Networking and MALDI Imaging https://doi.org/10.1177/1934578X1901400117

New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum 10.3390/md18020084

Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién 10.1371/journal.pone.0214193

19-Hydroxy-bufalin, a major bufadienolide isolated from the parotoid gland secretions of the Panamanian endemic toad Rhinella centralis (Bufonidae), inhibits the growth of Trypanosoma cruzi 10.1016/j.toxicon.2020.02.009

Reproducible molecular networking of untargeted mass spectrometry data using GNPS 10.1038/s41596-020-0317-5

Genome Mining, Microbial Interactions, and Molecular Networking Reveals New Dibromoalterochromides from Strains of Pseudoalteromonas of Coiba National Park-Panama 10.3390/md18090456

Metabolites from Microbes Isolated from the Skin of the Panamanian Rocket Frog Colostethus panamansis (Anura: Dendrobatidae) 10.3390/metabo10100406

Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens 10.3390/antibiotics9120843

Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327 10.3390/antibiotics9120923

Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi 10.3390/molecules26144217

jehad almaliti

almaliti jehad

ORCID: 0000-0002-3562-0846

Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel 10.1016/j.chembiol.2016.04.008

Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria 10.1021/acs.jnatprod.5b00301

Natural products inspired synthesis of neuroprotective agents against H2O2-induced cell death 10.1016/j.bmcl.2013.01.013

Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034

Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367

20S proteasome as a drug target in Trichomonas vaginalis 10.1128/AAC.00448-19

Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290

Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity 10.1021/acs.jmedchem.7b00671

The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni 10.1021/acsinfecdis.9b00237

Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents 10.1016/j.ejmech.2018.10.024

Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain 10.1021/acs.jmedchem.9b00294

Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue 10.1021/acs.jmedchem.6b01271