Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria
Kleigrewe, Karin Almaliti, Jehad Tian, Isaac Yuheng Kinnel, Robin B. Korobeynikov, Anton Monroe, Emily A. Duggan, Brendan M. Di Marzo, Vincenzo Sherman, David H. Dorrestein, Pieter C. Gerwick, Lena Gerwick, William H.
Vincenzo Di Marzo
Di Marzo Vincenzo
ORCID: 0000-0002-1490-3070
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Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats 10.1523/JNEUROSCI.0114-12.2012
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Enhanced cognitive performance of dopamine D3 receptor " knock-out" mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid/endovanilloid systems 10.1016/j.phrs.2010.02.003
N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities 10.1016/j.biochi.2010.01.006
The plant cannabinoid Δ 9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice 10.1111/j.1476-5381.2010.00756.x
Protective role of palmitoylethanolamide in contact allergic dermatitis 10.1111/j.1398-9995.2009.02254.x
The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice 10.1016/j.phrs.2010.02.001
Phytocannabinoids beyond the Cannabis plant - Do they exist? 10.1111/j.1476-5381.2010.00745.x
Possible Anandamide and Palmitoylethanolamide involvement in human stroke 10.1186/1476-511X-9-47
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Exploiting Nanotechnologies and TRPV1 Channels to Investigate the Putative Anandamide Membrane Transporter 10.1371/journal.pone.0010239
In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists 10.1016/j.phrs.2009.11.011
Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring 10.1210/en.2009-1092
Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish 10.1016/j.ygcen.2009.09.017
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Cannabimovone, a cannabinoid with a rearranged terpenoid skeleton from hemp 10.1002/ejoc.200901464
The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma 10.1210/en.2009-0883
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TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders 10.1002/9780470588284.ch10
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An endocannabinoid tone limits excitotoxicity in vitro and in a model of multiple sclerosis 10.1016/j.nbd.2009.09.020
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Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands 10.1016/j.bmcl.2009.09.033
Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects 10.1530/EJE-09-0643
CB1 antagonists for obesitywhat lessons have we learned from rimonabant? 10.1038/nrendo.2009.197
Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis 10.1007/s00109-009-0512-x
The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine 10.1016/j.plefa.2009.05.026
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems 10.1016/j.nbd.2009.06.015
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb 10.1016/
Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N- alkylacetamides as CB2 receptor ligands 10.1021/cc9000955
Peripheral endocannabinoid dysregulation in obesity: Relation to intestinal motility and energy processing induced by food deprivation and re-feeding 10.1111/j.1476-5381.2009.00183.x
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The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation 10.1016/j.phrs.2009.02.010
The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis 10.1073/pnas.0812789106
Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: Interactions with muscarinic and δ-opioid receptors 10.1016/j.bbamcr.2009.05.002
Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists 10.1021/jm801563d
TRPV1 channels control synaptic plasticity in the developing superior colliculus 10.1113/jphysiol.2009.171900
Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol 10.1002/cmdc.200800442
Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats 10.1111/j.1582-4934.2008.00353.x
Endocannabinoid chemical biology: a tool for the development of novel therapies 10.1016/j.cbpa.2009.04.616
Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia 10.1017/S1461145708009371
Role of endocannabinoids and endovanilloids in Ca2+ signalling 10.1016/j.ceca.2009.03.003
The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation 10.1038/ijo.2009.67
From endocannabinoid profiling to 'endocannabinoid therapeutics' 10.1016/j.cbpa.2009.04.615
Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes 10.1021/jm900130m
Functional interaction between TRPV1 and μ-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia 10.1152/jn.91225.2008
New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo 10.1021/jm8016255
Anti-inflammatory effect of palmitoylethanolamide on human adipocytes 10.1038/oby.2008.591
Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide 10.1194/jlr.M800337-JLR200
The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption 10.1016/j.bone.2008.10.056
Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: Associations with changes in metabolic risk factors 10.1007/s00125-008-1178-6
Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels 10.1038/npp.2008.98
The endocannabinoid system in metabolic control: a preface 10.1016/j.beem.2008.12.005
An introduction to the endocannabinoid system: from the early to the latest concepts 10.1016/j.beem.2008.10.013
Lipidomic methodologies applicable to the study of endocannabinoids and related compounds: Endocannabinoidomics 10.1002/ejlt.200800233
The endocannabinoid system is modulated in response to spinal cord injury in rats 10.1016/j.nbd.2008.09.015
Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo 10.1016/j.bbalip.2008.10.007
New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide 10.1021/jm800807k
Dopamides, vanillylamides, ethanolamides, and arachidonic acid amides of anti-inflammatory and analgesic drug substances as TRPV1 ligands 10.1002/cmdc.200800271
The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons 10.1523/JNEUROSCI.0847-08.2008
CB1 receptor antagonism: biological basis for metabolic effects 10.1016/j.drudis.2008.09.001
Endocannabinoids: Synthesis and degradation 10.1007/112-0505
The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats 10.1016/j.neuropharm.2008.06.023
Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin 10.1016/j.neuropharm.2008.01.010
Brain TRPV1: a depressing TR(i)P down memory lane? 10.1016/
Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism 10.1021/jm800978m
The anandamide membrane transporter inhibitor, VDM-11, modulates sleep and c-Fos expression in the rat brain 10.1016/j.neuroscience.2008.08.056
Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: Cross-talk between κ-opioid and cannabinoid CB 1 receptors 10.1038/bjp.2008.294
Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: Cannabinoid and non-cannabinoid receptor-mediated mechanisms 10.1038/bjp.2008.308
Neuronal and glial alterations in the cerebellar cortex of maternally deprived rats: Gender differences and modulatory effects of two inhibitors of endocannabinoid inactivation 10.1002/dneu.20672
Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: A possible role for the endocannabinoid system 10.1002/dneu.20666
Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo 10.1021/jm800552f
Play an ADAGIO with a STRADIVARIUS: The right patient for CB1 receptor antagonists? 10.1038/ncpcardio1319
Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide 10.1111/j.1460-9568.2008.06377.x
The endocannabinoid system in obesity and type 2 diabetes 10.1007/s00125-008-1048-2
The role of the endocannabinoid system in alzheimer's disease: Facts and hypotheses 10.2174/138161208785740027
Rimonabant in rats with a metabolic syndrome: Good news after the depression 10.1038/bjp.2008.170
Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning 10.1073/pnas.0803545105
Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex 10.1093/cercor/bhm161
Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8 10.1124/jpet.107.134809
New tetrazole-based selective anandamide uptake inhibitors 10.1016/j.bmcl.2008.04.003
Endocannabinoids: Some like it fat (and sweet too) 10.1111/j.1365-2826.2008.01678.x
FAAH and anandamide: is 2-AG really the odd one out? 10.1016/
The CB1 cannabinoid receptor antagonist AM251 attenuates amphetamine-induced behavioural sensitization while causing monoamine changes in nucleus accumbens and hippocampus 10.1016/j.pbb.2008.01.010
Targeting the endocannabinoid system: To enhance or reduce? 10.1038/nrd2553
Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets 10.1016/j.mce.2008.01.026
Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice 10.1007/s00109-008-0305-7
Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides 10.1021/jm070566z
The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization 10.1016/j.bbr.2007.09.022
The role of endocannabinoids in the regulation of gastric emptying: Alterations in mice fed a high-fat diet 10.1038/sj.bjp.0707682
Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet 10.1038/oby.2007.106
Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain 10.1016/j.neuroscience.2007.11.047
Why endocannabinoids are not all alike 10.1038/nn0208-124
Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon 10.1007/s00109-007-0248-4
Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revisitation 10.1016/j.ejmech.2007.02.023
TRPV1 receptors in the central nervous system: Potential for previously unforseen therapeutic applications 10.2174/138161208783330790
Effect of polyunsaturated fatty acids on endocannabinoid and N-acyl-ethanolamine levels in mouse adipocytes 10.1016/j.bbalip.2007.11.001
Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease 10.1016/j.neuint.2007.06.031
Editorial: New potential therapies from vanilloid transient receptor cation (TRPV) channels 10.2174/138161208783330736
Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: Insulin and melanocortins 10.1016/j.neuropharm.2007.06.011
The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling 10.1096/fj.06-7957com
Endocannabinoids in energy homeostasis and metabolic disorders 10.1007/978-0-387-74349-3_14
The 1,2,3-triazole ring as a peptido- and olefinomimetic element: Discovery of click yanilloids and cannabinoids 10.1002/anie.200703590
New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain 10.1021/jm070678q
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists 10.1016/j.bmcl.2007.09.089
Enantioselective synthesis and vanilloid activity evaluation of 1-β-(p-methoxycinnamoyl)polygodial, an antinociceptive compound from Drymis winteri barks 10.1016/j.bmcl.2007.10.001
Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro 10.1007/s00109-007-0233-y
Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders 10.1016/j.phrs.2007.09.002
Role and regulation of acylethanolamides in energy balance: Focus on adipocytes and β-cells 10.1038/sj.bjp.0707424
Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs 10.1016/j.bmcl.2007.06.055
Opposing control of cannabinoid receptor stimulation on amyloid-β-induced reactive gliosis: In vitro and in vivo evidence 10.1124/jpet.107.121566
Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma β-cells 10.1016/j.yexcr.2007.05.012
Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors 10.1016/j.bmc.2007.05.060
Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus 10.1038/sj.bjp.0707313
Endocannabinoids and Related Compounds: Walking Back and Forth between Plant Natural Products and Animal Physiology 10.1016/j.chembiol.2007.05.014
Enantioselective synthesis of 1-(R)-hydroxypolygodial and its 9α epimer, 1-(R)-hydroxyisotadeonal 10.1016/j.tet.2007.04.059
Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception 10.1152/jn.00356.2007
Attenuation of allergic contact dermatitis through the endocannabinoid system 10.1126/science.1142265
Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): Effect of cAMP, cannabinoid CB1 receptors and endovanilloids 10.1016/j.yexcr.2007.01.008
Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats 10.1007/s00109-007-0192-3
Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret 10.1111/j.1460-9568.2007.05521.x
Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men 10.1038/sj.ijo.0803539
Endocannabinoids and the regulation of their levels in health and disease 10.1097/MOL.0b013e32803dbdec
Identification of endocannabinoids and related compounds in human fat cells 10.1038/oby.2007.581
The endocannabinoid system for the development of new drugs for spasticity 10.1358/dof.2007.032.04.1083482
Biochemistry and pharmacology of endovanilloids 10.1016/j.pharmthera.2007.01.005
Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors 10.1038/sj.bjp.0707145
Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats 10.1016/j.neuropharm.2006.08.011
N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors 10.1038/sj.npp.1301118
Structure-based virtual screening: Identification of novel CB2 receptor ligands 10.2174/157018007778992829
Endocannabinoids and the control of energy balance 10.1016/j.tem.2006.11.006
Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: Potential use in companion animals 10.1016/j.tvjl.2005.10.003
Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration 10.1016/j.plefa.2006.08.002
Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol 10.1113/jphysiol.2006.119362
In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands 10.1038/sj.bjp.0706888
Endocannabinoid overactivity and intestinal inflammation 10.1136/gut.2005.090472
Neuropathic pain and the endocannabinoid system in the dorsal raphe: Pharmacological treatment and interactions with the serotonergic system 10.1111/j.1460-9568.2006.05086.x
Protective activation of the endocannabinoid system during ischemia in dopamine neurons 10.1016/j.nbd.2006.04.010
Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes 10.1523/JNEUROSCI.0153-06.2006
A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats 10.1016/j.neuropharm.2006.04.016
Synthesis, conformational analysis and CB1 binding affinity of hairpin-like anandamide pseudopeptide mimetics 10.1002/psc.754
Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia 10.1210/jc.2005-2679
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma 10.1124/jpet.106.105247
Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation 10.1128/MCB.00397-06
Neural contractions in colonic strips from patients with diverticular disease: Role of endocannabinoids and substance P 10.1136/gut.2005.076372
Endocannabinoids and β-amyloid-induced neurotoxicity in vivo: Effect of pharmacological elevation of endocannabinoid levels 10.1007/s00018-006-6037-3
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain 10.1016/j.neuroscience.2006.02.074
Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice 10.1096/fj.05-4743fje
Development of the first potential covalent inhibitors of anandamide cellular uptake 10.1021/jm051226l
Oxyhomologues of anandamide and related endolipids: Chemoselective synthesis and biological activity 10.1021/jm051240y
Endocannabinoids, feeding and suckling - From our perspective 10.1038/sj.ijo.0803274
Endogenous cannabinoids in the brain and peripheral tissues: Regulation of their levels and control of food intake 10.1038/sj.ijo.0803271
Iodinated N-acylvanillamines: Potential "multiple-target" anti-inflammatory agents acting via the inhibition of T-cell activation and antagonism at vanilloid TRPV1 channels 10.1124/mol.105.019786
The endocannabinoid and endovanilloid systems and their interactions in neuropathic pain 10.1002/ddr.20098
Evolutionary origins of the endocannabinoid system 10.1016/j.gene.2005.11.004
Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: Therapeutic implications 10.1016/j.biopsych.2005.08.019
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors 10.1124/jpet.105.093286
A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists 10.1016/
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation 10.1096/fj.05-4943fje
Plant, synthetic, and endogenous cannabinoids in medicine 10.1146/
Anandamide inhibits adhesion and migration of breast cancer cells 10.1016/j.yexcr.2005.10.024
Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis 10.1016/j.jneuroim.2005.09.005
Development of the first potent and specific inhibitors of endocannabinoid biosynthesis 10.1016/j.bbalip.2005.12.009
First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB 2 receptors and non-polyunsaturated fatty acid-derived CB 2-selective ligands 10.1016/j.febslet.2005.12.069
New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis 10.1038/sj.bjp.0706418
New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies 10.1016/j.bmcl.2005.09.023
The biosynthesis, fate and pharmacological properties of endocannabinoids 10.1007/3-540-26573-2-5
The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake 10.1111/j.1471-4159.2005.03406.x
Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis 10.1016/j.nbd.2005.03.002
Neuroscience: Identification and functional characterization of brainstem cannabinoid CB2 receptors 10.1126/science.1115740
Erratum: Anandamide acts as an intracellular messenger amplifying Ca 2+ influx via TRPV1 channels (EMBO Journal (2005) 24 (3026-3037) DOI: 10.1038/sj.emboj.7600784 10.1038/sj.emboj.7600839
Fatty acid amide hydrolase controls mouse intestinal motility in vivo 10.1053/j.gastro.2005.06.018
Anandamide as an intracellular messenger regulating ion channel activity 10.1016/j.prostaglandins.2004.09.007
Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels 10.1038/sj.emboj.7600784
Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew 10.1016/j.neuropharm.2005.04.007
Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels 10.1016/j.lfs.2005.05.021
Targeted lipidomics: Endocannabinoids and other endolipid modulators 10.1016/j.lfs.2005.05.001
Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels 10.1016/j.bcp.2005.05.011
Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis 10.1096/fj.04-2464fje
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease 10.1016/j.brainres.2005.05.024
The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination 10.1021/jm050139q
A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease 10.1096/fj.04-3010fje
Occurrence and possible biological role of the endocannabinoid system in the sea squirt Ciona intestinalis 10.1111/j.1471-4159.2005.03103.x
Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa 10.1038/sj.npp.1300695
The endocannabinoid signalling system: Biochemical aspects 10.1016/j.pbb.2005.01.027
Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies 10.1016/j.neuropharm.2005.01.001
Finding of endocannabinoids in human eye tissues: Implications for glaucoma 10.1016/j.bbrc.2005.03.095
Endocannabinoid control of food intake and energy balance 10.1038/nn1457
Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis 10.1111/j.1471-4159.2004.02979.x
Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential 10.1124/jpet.104.074864
Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility 10.1093/molehr/gah130
Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase 10.1016/j.lfs.2004.09.005
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons 10.1523/JNEUROSCI.3502-04.2004
Endocannabinoids link feeding state and auditory perception-related gene expression 10.1523/JNEUROSCI.3298-04.2004
Changes in endocannabinoid contents in reward-related brain regions of alcohol-exposed rats, and their possible relevance to alcohol relapse 10.1038/sj.bjp.0705963
Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine 10.1111/j.1460-9568.2004.03645.x
The anandamide membrane transporter. Structureâ€"activity relationships of anandamide and oleoylethanolamine analogs with phenyl rings in the polar head group region 10.1016/j.bmc.2004.07.026
A new strategy to block tumor growth by inhibiting endocannabinoid inactivation 10.1096/fj.04-1754fje
Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels 10.1038/sj.bjp.0705924
The endocannabinoid system and its therapeutic exploitation 10.1038/nrd1495
Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids 10.1002/ejoc.200400122
Further evidence for the existence of a specific process for the membrane transport of anandamide 10.1042/BJ20031812
Behavioral and molecular changes elicited by acute administration of SR141716 to Δ9-tetrahydrocannabinol-tolerant rats: An experimental model of cannabinoid abstinence 10.1016/j.drugalcdep.2003.12.011
Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis - A difficult issue to handle 10.1016/j.ejphar.2004.03.048
Endovanilloids: Putative endogenous ligands of transient receptor potential vanilloid 1 channels 10.1111/j.1432-1033.2004.04081.x
Prostaglandin Ethanolamides (Prostamides): In Vitro Pharmacology and Metabolism 10.1124/jpet.103.061705
Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain 10.1007/s00018-003-3453-5
The endocannabinoid system: A general view and latest additions 10.1038/sj.bjp.0705666
A structure-activity relationship study on N -arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase 10.1016/j.bbrc.2003.12.075
In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake 10.1016/j.ejphar.2003.11.027
Metabolic fate of endocannabinoids 10.2174/1570159043476864
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain 10.1083/jcb.200305129
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: Implications for neurological and psychiatric disorders 10.1016/j.ejphar.2003.08.101
Erratum: Corrigendum to Halogenation of a capsaicin analogue leads to novel vanilloid TRPVI receptor antagonists (British Journal Pharmacology (2003) 139 (1417-1424)) 10.1038/sj.bjp.0705565
The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway 10.1038/sj.bjp.0705532
CB1 cannabinoid receptors and on-demand defense against excitotoxicity 10.1126/science.1088208
Semiplenamides A-G, Fatty Acid Amides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya semiplena 10.1021/np030242n
An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice 10.1016/S0016-5085(03)00892-8
Possible endocannabinoid control of colorectal cancer growth 10.1016/S0016-5085(03)00881-3
Endocannabinoid signalling in the blood of patients with schizophrenia 10.1186/1476-511X-2-1
Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder 10.1016/S0014-2999(03)02114-9
Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists 10.1038/sj.bjp.0705387
Endocannabinoids and related fatty acid amides, and their regulation, in the salivary glands of the lone star tick 10.1016/S1388-1981(03)00087-8
Manipulation of the endocannabinoid system by a general anaesthetic 10.1038/sj.bjp.0705333
Novel selective and metabolically stable inhibitors of anandamide cellular uptake 10.1016/S0006-2952(03)00109-6
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia 10.1074/jbc.M211231200
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease 10.1046/j.1471-4159.2003.01595.x
Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response 10.1007/s000180300052
Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels 10.1007/s000180300031
Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway 10.1124/mol.63.2.429
Homologues and isomers of noladin ether, a putative novel endocannabinoid: Interaction with rat cannabinoid CB1 receptors 10.1016/S0960-894X(02)00839-9
The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation 10.1074/jbc.M207170200
Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems 10.1046/j.1472-8206.2002.00094.x
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine 10.1016/S0006-8993(02)03344-9
Acute neuronal injury, excitotoxicity, and the endocannabinoid system 10.1385/MN:26:2-3:317
Presence and regulation of the endocannabinoid system in human dendritic cells 10.1046/j.1432-1033.2002.03078.x
N-acylvanillamides: Development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor 10.1021/jm020844o
Erratum: "The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats" (Life Sciences (2002) 70:12 (1407-1414) PII: S0024320501015168) 10.1016/S0024-3205(02)01800-3
The endogenous cannabinoid system controls extinction of aversive memories 10.1038/nature00839
Endovanilloid signaling in pain 10.1016/S0959-4388(02)00340-9
Endocannabinoids as physiological regulators of colonic propulsion in mice 10.1053/gast.2002.34242
Anandamide receptors 10.1054/plef.2001.0349
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A marine mollusc provides the first example of in vivo storage of prostaglandins: Prostaglandin-1,15-lactones 10.1007/BF02041252
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β-Endorphin in Neoroblastoma x Glioma hybrid cells 10.1016/0143-4179(85)90130-1
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Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition 10.1039/c6ra12524g
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2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons 10.1007/s00213-015-3917-y
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Placidenes: cyercene-like polypropionate γ-pyrones from the mediterranean ascoglossan mollusc Placida dendritica 10.1016/S0040-4039(00)78884-8
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Anandamide and decidual remodelling: COX-2 oxidative metabolism as a key regulator 10.1016/j.bbalip.2015.08.011
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Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 10.1080/15384047.2015.1078028
The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels 10.1111/bph.13084
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Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women with Endometriosis 10.1177/1933719116630414
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Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB1R signaling and anxiety-like behavior 10.1111/jnc.13267
Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis 10.1016/j.tvjl.2015.10.060
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At the tip of an iceberg: Prenatal marijuana and its possible relation to neuropsychiatric outcome in the offspring 10.1016/j.biopsych.2015.09.009
Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel 10.1016/j.phrs.2015.07.009
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The endocannabinoid system in renal cells: Regulation of Na <sup>+</sup> transport by CB<inf>1</inf> receptors through distinct cell signalling pathways 10.1111/bph.13050
Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons 10.1021/jacs.5b04883
Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors 10.1189/jlb.3HI1214-584R
Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis 10.1016/j.jhep.2015.01.001
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Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 10.1021/acs.jmedchem.6b00609
A multi-target approach for pain treatment: Dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis 10.1097/j.pain.0000000000000132
Polypharmacology Shakes Hands with Complex Aetiopathology 10.1016/
Peripheral Endocannabinoid Responses to Hedonic Eating in Binge-Eating Disorder 10.3390/nu9121377
Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists 10.1021/acs.jmedchem.8b00734
Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy 10.1111/bph.14495
Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest 10.3390/md16110431
In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator 10.3390/md17020110
Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and N-Acylethanolamines in Patients with Mastocytosis 10.1155/2019/5836476
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Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach 10.1016/j.bbagen.2019.01.002
Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system 10.1016/j.bcp.2019.01.001
Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia 10.1016/j.neuropharm.2018.11.035
FAAH-Catalyzed C–C Bond Cleavage of a New Multitarget Analgesic Drug 10.1021/acschemneuro.8b00315
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease 10.1016/j.ejmech.2018.09.070
Effects of diisononyl phthalate (DiNP) on the endocannabinoid and reproductive systems of male gilthead sea bream (Sparus aurata) during the spawning season 10.1007/s00204-018-2378-6
Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway 10.1016/j.nbd.2018.09.023
CB1 receptor activation induces intracellular Ca2+ mobilization and 2-arachidonoylglycerol release in rodent spinal cord astrocytes 10.1038/s41598-018-28763-6
Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy 10.1038/s41467-018-06267-1
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 10.1002/cmdc.201800397
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Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish 10.1016/j.chemosphere.2018.04.078
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Endocannabinoid Tone Regulates Human Sebocyte Biology 10.1016/j.jid.2018.02.022
Overlapping Distribution of Orexin and Endocannabinoid Receptors and Their Functional Interaction in the Brain of Adult Zebrafish 10.3389/fnana.2018.00062
Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis 10.1124/jpet.117.244368
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The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine 10.1016/j.jpain.2017.12.002
Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect 10.3389/fphar.2018.00249
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Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice 10.1016/j.bbi.2017.09.001
Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse 10.3389/fphar.2017.00857
Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects 10.3389/fphys.2017.01006
Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids 10.1038/s41598-017-01562-1
Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT) 10.1111/nmo.13148
Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor 10.1038/s41598-017-00342-1
Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study 10.1186/s12917-017-1245-7
Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish 10.1210/en.2017-00458
Dual therapy targeting the endocannabinoid system prevents experimental diabetic nephropathy 10.1093/ndt/gfx010
Effects of curcumin and curcumin analogues on TRP channels 10.1016/j.fitote.2017.09.007
A TRPV 1‐to‐secretagogin regulatory axis controls pancreatic β‐cell survival by modulating protein turnover 10.15252/embj.201695347
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 10.1126/science.aaf7497
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The Endocannabinoid System in Leptin-Driven Changes of Orexinergic Signaling Under Physiological and Pathological Conditions 10.1007/978-3-319-57371-7_1
2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation 10.3389/fphar.2017.00308
Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion 10.1080/16546628.2017.1297553
Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE) 10.1016/j.phrs.2017.02.019
Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis 10.1016/j.phrs.2017.02.002
Development of a Rapid LC-MS/MS Method for the Quantification of Cannabidiol, Cannabidivarin, Δ9-Tetrahydrocannabivarin, and Cannabigerol in Mouse Peripheral Tissues 10.1021/acs.analchem.7b01094
CB 1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal 10.1016/j.biopsych.2016.07.007
Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor 10.1016/j.ejps.2017.01.037
Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome 10.1111/apt.13958
Plasma palmitoylethanolamide (PEA) as a potential biomarker for impaired coronary function 10.1016/j.ijcard.2016.12.023
The time course of erythrocyte membrane fatty acid concentrations during and after treatment of non-human primates with increasing doses of an omega-3 rich phospholipid preparation derived from krill-oil 10.1186/s12944-017-0414-9
Role of the endocannabinoid system in the control of mouse myometrium contractility during the menstrual cycle 10.1016/j.bcp.2016.11.023
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity 10.1038/ncomms13958
The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations 10.1111/bph.13580
Techniques for the Cellular and Subcellular Localization of Endocannabinoid Receptors and Enzymes in the Mammalian Brain 10.1016/bs.mie.2017.05.003
Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes 10.3390/ijms20205003
Cannabidiol improves vocal learning-dependent recovery from, and reduces magnitude of deficits following, damage to a cortical-like brain region in a songbird pre-clinical animal model 10.1016/j.neuropharm.2019.107716
Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties 10.1016/j.ejmech.2019.07.002
Human leukocytes differentially express endocannabinoid‐glycerol lipases and hydrolyze 2‐arachidonoyl‐glycerol and its metabolites from the 15‐lipoxygenase and cyclooxygenase pathways 10.1002/jlb.3a0919-049rrr
The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients 10.1016/j.phrs.2019.104464
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A Designer Diet Induces Thermogenic Adipocytes via Raptor and Prolongs Healthy Lifespan 10.2139/ssrn.3435269
Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome 10.3390/nu11081956
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 10.1016/j.ejmech.2019.05.080
Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice 10.1177/0269881119844184
Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague–Dawley rats 10.1007/s00213-019-05237-9
Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain 10.1016/j.bbi.2019.04.006
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice 10.1016/j.neuropharm.2018.03.020
Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis 10.1038/s41467-018-08051-7
Targeted Lipidomics Investigation of N ‐acylethanolamines in a Transgenic Mouse Model of AD: A Longitudinal Study 10.1002/ejlt.201900015
Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier 10.3389/fendo.2019.00219
Author Correction: CB1 receptor activation induces intracellular Ca2+ mobilization and 2-arachidonoylglycerol release in rodent spinal cord astrocytes 10.1038/s41598-018-30573-9
5th EFLM-UEMS European Joint Congress in Laboratory Medicine 10.1515/cclm-2018-1038
Role of N-Arachidonoyl-Serotonin (AA-5-HT) in Sleep-Wake Cycle Architecture, Sleep Homeostasis, and Neurotransmitters Regulation 10.3389/fnmol.2017.00152
Cannabinoids and the expanded endocannabinoid system in neurological disorders 10.1038/s41582-019-0284-z
Obesity Affects the Microbiota–Gut–Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators 10.3390/ijms21051554
Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism 10.3390/cells9051247
Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen–Glucose Deprivation-Induced Neuronal Injury 10.3390/cells9061507
Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota 10.3390/cells9122705
Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models 10.3390/cells10010071
Cannabinoids: a class of unique natural products with unique pharmacology 10.1007/s12210-020-00966-y
A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator 10.3390/cells10020450
Anton Korobeynikov
Korobeynikov Anton
ORCID: 0000-0002-2937-9259
Single cell genome analysis of an uncultured heterotrophic stramenopile 10.1038/srep04780
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Estimation of ion-site association constants in ion-selective electrode membranes by modified segmented sandwich membrane method 10.1016/j.electacta.2008.03.030
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria 10.1021/acs.jnatprod.5b00301
Spongosine production by a vibrio harveyi strain associated with the sponge tectitethya crypta 10.1021/np5009762
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Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genusMoorea 10.1073/pnas.1618556114
metaSPAdes: a new versatile metagenomic assembler 10.1101/gr.213959.116
Increased diversity of peptidic natural products revealed by modification-tolerant database search of mass spectra 10.1038/s41564-017-0094-2
Dereplication of microbial metabolites through database search of mass spectra 10.1038/s41467-018-06082-8
PathRacer: racing profile HMM paths on assembly graph 10.1101/562579
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BiosyntheticSPAdes: reconstructing biosynthetic gene clusters from assembly graphs 10.1101/gr.243477.118
coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies 10.1101/2020.07.28.224584
coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies 10.1093/bioinformatics/btab597
Brendan Duggan
Duggan Brendan / Brendan M. Duggan
ORCID: 0000-0002-7034-8374
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin 10.1038/nchembio.2157
Three-dimensional Structure in Solution of the Calcium Channel Blocker ω-Conotoxin 10.1006/jmbi.1993.1595
The Arginine-Rich RNA-Binding Motif of HIV-1 Rev Is Intrinsically Disordered and Folds upon RRE Binding 10.1016/j.bpj.2013.07.022
1H, 13C and 15N assignments of the holo-acyl carrier protein of Pseudomonas aeruginosa 10.1007/s12104-012-9415-9
Microbial metabolic exchange in 3D 10.1038/ismej.2012.155
NMR assignments of the N-terminal domain of Nephila clavipes spidroin 1 10.1007/s12104-010-9284-z
The Alga Ochromonas danica Produces Bromosulfolipids 10.1021/acs.orglett.6b00230
Bioactivity-Guided Genome Mining Reveals the Lomaiviticin Biosynthetic Gene Cluster in Salinispora tropica 10.1002/cbic.201300147
Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin 10.1016/0167-4838(95)00182-4
Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes 10.1042/bj20121612
Efficient red light photo-uncaging of active molecules in water upon assembly into nanoparticles 10.1039/c5sc03717d
Inherent flexibility in a potent inhibitor of blood coagulation, recombinant nematode anticoagulant protein c2 10.1046/j.1432-1327.1999.00781.x
Ultra-high resolution band-selective HSQC for nanomole-scale identification of chlorine-substituted13C in natural products drug discovery 10.1002/mrc.4415
A Distal Mutation Perturbs Dynamic Amino Acid Networks in Dihydrofolate Reductase 10.1021/bi400563c
Detailed Analysis of (−)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists 10.1021/np500644k
Conformational dynamics of thyroid hormones by variable temperature nuclear magnetic resonance: The role of side chain rotations and cisoid/transoid interconversions 10.1021/jm9606610
Contribution of increased length and intact capping sequences to the conformational preference for helix in a 31-residue peptide from the C terminus of myohemerythrin 10.1021/bi970038x
1 H and 13 C NMR Relaxation Studies of Molecular Dynamics of the Thyroid Hormones Thyroxine, 3,5,3‘-Triiodothyronine, and 3,5-Diiodothyronine † 10.1021/jm960231+
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus 10.1038/ja.2013.99
Mollenynes B-E from the Marine Sponge Spirastrella mollis. Band-Selective Heteronuclear Single Quantum Coherence for Discrimination of Bromo-Chloro Regioisomerism in Natural Products 10.1021/jacs.5b07858
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria 10.1021/acs.jnatprod.5b00301
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-017-13923-x
Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules 10.1073/pnas.1315492110
Messenger RNAs under differential translational control in Ki-ras-transformed cells 10.1158/1541-7786.MCR-04-0187
SANE (Structure Assisted NOE Evaluation): An automated model-based approach for NOE assignment 10.1023/A:1011227824104
Potential bias in NMR relaxation data introduced by peak intensity analysis and curve fitting methods 10.1023/A:1011966718826
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides 10.1038/nmicrobiol.2016.197
MS/MS networking guided analysis of molecule and gene cluster families 10.1073/pnas.1303471110
Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae 10.7554/eLife.24214
Interkingdom metabolic transformations captured by microbial imaging mass spectrometry 10.1073/pnas.1206855109
Identification of a 3-alkylpyridinium compound from the red sea sponge Amphimedon chloros with in vitro inhibitory activity against the West Nile Virus NS3 protease 10.3390/molecules23061472
Toward Expanded Diversity of Host–Guest Interactions via Synthesis and Characterization of Cyclodextrin Derivatives 10.1007/s10953-018-0769-1
Facile synthesis of a diverse library of mono-3-substituted β-cyclodextrin analogues 10.1080/10610278.2018.1562191
Lepadins I–K, 3-O-(3′-Methylthio)acryloyloxy-decahydroquinoline Esters from a Bahamian Ascidian Didemnum sp. Assignment of Absolute Stereostructures 10.1021/acs.joc.8b01609
Editorial to the Special Issue—“Technology for Natural Products Research” 10.3390/molecules25020327
The Pierced Lasso Topology Leptin has a Bolt on Dynamic Domain Composed by the Disordered Loops I and III 10.1016/j.jmb.2020.01.035
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-020-60108-0
Commensal Oral Rothia mucilaginosa Produces Enterobactin, a Metal-Chelating Siderophore 10.1128/mSystems.00161-20
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides 10.1038/nmicrobiol.2017.10
Experimental characterization of the association of β-cyclodextrin and eight novel cyclodextrin derivatives with two guest compounds 10.1007/s10822-020-00350-w
A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products 10.1021/jacs.9b13786
Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties 10.1021/acschembio.9b00992
Searching for Small Molecules with an Atomic Sort 10.1002/anie.201911862
Searching for Small Molecules with an Atomic Sort 10.1002/anie.202000826
Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for α7 nAChRs 10.1021/acs.jmedchem.9b01467
jehad almaliti
almaliti jehad
ORCID: 0000-0002-3562-0846
Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel 10.1016/j.chembiol.2016.04.008
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria 10.1021/acs.jnatprod.5b00301
Natural products inspired synthesis of neuroprotective agents against H2O2-induced cell death 10.1016/j.bmcl.2013.01.013
Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367
20S proteasome as a drug target in Trichomonas vaginalis 10.1128/AAC.00448-19
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity 10.1021/acs.jmedchem.7b00671
The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni 10.1021/acsinfecdis.9b00237
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents 10.1016/j.ejmech.2018.10.024
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain 10.1021/acs.jmedchem.9b00294
Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue 10.1021/acs.jmedchem.6b01271