Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain
Paul D. Boudreau
Bailey W. Miller
Laura-Isobel McCall
Jehad Almaliti
Raphael Reher
Ken Hirata
Thu Le
Jair L. Siqueira-Neto
Vivian Hook
William H. Gerwick
Raphael Reher
Reher Raphael
ORCID: 0000-0002-5858-1173
A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria
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Heterologous Expression of Cryptomaldamide in a Cyanobacterial Host
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Cell‐permeable high‐affinity tracers for G
q
proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors
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A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Products
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A community resource for paired genomic and metabolomic data mining
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Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain
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Structural and Dynamical Basis of G Protein Inhibition by YM-254890 and FR900359: An Inhibitor in Action
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Direct targeting of Gαq and Gα11 oncoproteins in cancer cells
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The genome analysis of C
andidatus
Burkholderia crenata reveals that secondary metabolism may be a key function of the A
rdisia crenata
leaf nodule symbiosis
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William Gerwick
Gerwick William
ORCID: 0000-0003-1403-4458
Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata
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Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group
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Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke
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A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria
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Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
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5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34
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The Face of a Molecule
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A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit
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Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group
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Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp.
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Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β
10.1021/acschemneuro.7b00527
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Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta
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Structural Basis of Polyketide Synthase O-Methylation
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Dragocins A−D, Structurally Intriguing Cytotoxic Metabolites from a Panamanian Marine Cyanobacterium
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Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp.
10.1021/acs.orglett.8b04050
Nature's Combinatorial Biosynthesis Produces Vatiamides A–F
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Nature's Combinatorial Biosynthesis Produces Vatiamides A–F
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Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens
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Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain
10.1021/acs.jmedchem.9b00294
Commensal oralRothia mucilaginosaproduces enterobactin – a metal chelating siderophore
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Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity
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Commensal Oral Rothia mucilaginosa Produces Enterobactin, a Metal-Chelating Siderophore
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Correction to “Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp.”
10.1021/acs.orglett.0c02252
The Chemistry, Biochemistry and Pharmacology of Marine Natural Products from Leptolyngbya, a Chemically Endowed Genus of Cyanobacteria
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Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2
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Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A
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Cyanobacteria-shrimp colonies in the Mariana Islands
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Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium
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SIRT1 Activation Enhancing 8,3′-Neolignans from the Twigs of Corylopsis coreana Uyeki
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First Total Synthesis and Structure–Activity Relationship of Iheyamide A, an Antitrypanosomal Linear Peptide Isolated from a Dapis sp. Marine Cyanobacterium
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jehad almaliti
almaliti jehad
ORCID: 0000-0002-3562-0846
Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel
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Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria
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Natural products inspired synthesis of neuroprotective agents against H2O2-induced cell death
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Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens
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Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species
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20S proteasome as a drug target in Trichomonas vaginalis
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Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages
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Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
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The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni
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Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents
10.1016/j.ejmech.2018.10.024
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain
10.1021/acs.jmedchem.9b00294
Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue
10.1021/acs.jmedchem.6b01271
