Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
Gregory M. LaMonte Jehad Almaliti Betsaida Bibo-Verdugo Lena Keller Bing Yu Zou Jennifer Yang Yevgeniya Antonova-Koch Pamela Orjuela-Sanchez Colleen A. Boyle Edgar Vigil Lawrence Wang Gregory M. Goldgof Lena Gerwick Anthony J. O’Donoghue Elizabeth A. Winzeler William H. Gerwick Sabine Ottilie
Elizabeth Winzeler
Winzeler Elizabeth
ORCID: 0000-0002-4049-2113
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Lena Keller
Keller Lena / Lena Etzbach
ORCID: 0000-0003-2899-1232
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Biosynthese und heterologe Expression der Vioprolide: rationale gentechnische Eingriffe in die Biosynthese und 4-Methylazetidincarbonsäure-Bildung 10.1002/ange.201802479
Applying a Chemogeographic Strategy for Natural Product Discovery from the Marine Cyanobacterium Moorena bouillonii 10.3390/md18100515
William Gerwick
Gerwick William
ORCID: 0000-0003-1403-4458
Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata 10.3390/md15040121
Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group 10.3390/md16050163
Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease 10.3390/molecules23061472
MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria 10.3390/md16120505
Integrated Genomic and Metabolomic Approach to the Discovery of Potential Anti-Quorum Sensing Natural Products from Microbes Associated with Marine Samples from Singapore 10.3390/md17010072
Epicortical Brevetoxin Treatment Promotes Neural Repair and Functional Recovery after Ischemic Stroke 10.3390/md18070374
A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria 10.3390/md19010020
Kalkitoxin Reduces Osteoclast Formation and Resorption and Protects against Inflammatory Bone Loss 10.3390/ijms22052303
Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity 10.1021/acs.jmedchem.7b00671
5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34 10.3390/md15080260
The Face of a Molecule 10.1021/acs.jnatprod.7b00624
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research 10.1038/s41598-017-13923-x
A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit 10.1021/acschembio.7b00746
Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group 10.1021/acs.jnatprod.7b00917
Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp. 10.1021/acs.joc.8b00028
Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β 10.1021/acschemneuro.7b00527
Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module 10.1021/acschembio.8b00252
Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta 10.1021/acschembio.8b00910
Structural Basis of Polyketide Synthase O-Methylation 10.1021/acschembio.8b00687
Dragocins A−D, Structurally Intriguing Cytotoxic Metabolites from a Panamanian Marine Cyanobacterium 10.1021/acs.orglett.8b03712
Marine natural products as potential anti-tubercular agents 10.1016/j.ejmech.2019.01.026
Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp. 10.1021/acs.orglett.8b04050
Nature's Combinatorial Biosynthesis Produces Vatiamides A–F 10.1002/anie.201902571
Nature's Combinatorial Biosynthesis Produces Vatiamides A–F 10.1002/ange.201902571
Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.9b00549
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain 10.1021/acs.jmedchem.9b00294
Commensal oralRothia mucilaginosaproduces enterobactin – a metal chelating siderophore 10.1101/2020.02.20.956391
Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity 10.3390/molecules25071604
Commensal Oral Rothia mucilaginosa Produces Enterobactin, a Metal-Chelating Siderophore 10.1128/mSystems.00161-20
Correction to “Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp.” 10.1021/acs.orglett.0c02252
The Chemistry, Biochemistry and Pharmacology of Marine Natural Products from Leptolyngbya, a Chemically Endowed Genus of Cyanobacteria 10.3390/md18100508
Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2 10.1021/acs.jnatprod.0c00968
Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A 10.1021/acs.jnatprod.0c01317
Cyanobacteria-shrimp colonies in the Mariana Islands 10.1007/s10452-021-09837-6
Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium 10.1021/acs.jnatprod.0c01383
SIRT1 Activation Enhancing 8,3′-Neolignans from the Twigs of Corylopsis coreana Uyeki 10.3390/plants10081684
First Total Synthesis and Structure–Activity Relationship of Iheyamide A, an Antitrypanosomal Linear Peptide Isolated from a Dapis sp. Marine Cyanobacterium 10.1021/acs.jnatprod.1c00792
Gregory Goldgof
Goldgof Gregory / Gregory M. Goldgof
ORCID: 0000-0001-8732-9834
SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood. 10.1038/s41467-020-18468-8
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. 10.1038/s41587-020-0659-0
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. 10.1038/s41467-020-15440-4
Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies. 10.1186/s13321-018-0261-3
Mycobacterium tuberculosis Exploits a Molecular Off Switch of the Immune System for Intracellular Survival. 10.1038/s41598-017-18528-y
A broad analysis of resistance development in the malaria parasite. 10.1038/ncomms11901
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. 10.1021/acs.jmedchem.7b00671
Direct transfer of whole genomes from bacteria to yeast. 10.1038/nmeth.2433
Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. 10.1021/acschembio.6b01037
Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function. 10.1371/journal.pone.0185973
Kalkipyrone B, a marine cyanobacterial γ-pyrone possessing cytotoxic and anti-fungal activities. 10.1016/j.phytochem.2015.11.011
Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling. 10.1101/gr.182477.114
Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. 10.1038/srep27806
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. 10.1371/journal.ppat.1005763
Magnitude and Kinetics of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses and Their Relationship to Disease Severity. 10.1093/cid/ciaa979
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood. 10.1126/sciadv.abe5984
jehad almaliti
almaliti jehad
ORCID: 0000-0002-3562-0846
Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel 10.1016/j.chembiol.2016.04.008
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria 10.1021/acs.jnatprod.5b00301
Natural products inspired synthesis of neuroprotective agents against H2O2-induced cell death 10.1016/j.bmcl.2013.01.013
Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367
20S proteasome as a drug target in Trichomonas vaginalis 10.1128/AAC.00448-19
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity 10.1021/acs.jmedchem.7b00671
The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni 10.1021/acsinfecdis.9b00237
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents 10.1016/j.ejmech.2018.10.024
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain 10.1021/acs.jmedchem.9b00294
Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue 10.1021/acs.jmedchem.6b01271