Unsupervised Discovery and Comparison of Structural Families Across Multiple Samples in Untargeted Metabolomics
Justin van der Hooft
van der Hooft Justin / Justin J.J. van der Hooft
ORCID: 0000-0002-9340-5511
Structural elucidation of low abundant metabolites in complex sample matrices 10.1007/s11306-013-0519-8
Non-smoky GLYCOSYLTRANSFERASE1 prevents the release of smoky aroma from tomato fruit 10.1105/tpc.113.114231
Automatic chemical structure annotation of an LC-MSn based metabolic profile from green tea 10.1021/ac400861a
Substructure-based annotation of high-resolution multistage MSn spectral trees 10.1002/rcm.6364
Structural annotation and elucidation of conjugated phenolic compounds in black, green, and white tea extracts 10.1021/jf300297y
Structural elucidation and quantification of phenolic conjugates present in human urine after tea intake 10.1021/ac3017339
Spectral trees as a robust annotation tool in LC-MS based metabolomics 10.1007/s11306-011-0363-7
Metabolite identification using automated comparison of high-resolution multistage mass spectral trees 10.1021/ac2034216
Inhibitory activity of plumbagin produced by Drosera intermedia on food spoilage fungi 10.1002/jsfa.5522
A strategy for fast structural elucidation of metabolites in small volume plant extracts using automated MS-guided LC-MS-SPE-NMR 10.1002/mrc.2833
Thermal diffusivity of periderm from tomatoes of different maturity stages as determined by the concept of the frequency-domain open photoacoustic cell 10.1063/1.3530735
Polyphenol identification based on systematic and robust high-resolution accurate mass spectrometry fragmentation 10.1021/ac102546x
Iridoid and caffeoyl phenylethanoid glycosides of the endangered carnivorous plant Pinguicula lusitanica L. (Lentibulariaceae) 10.1016/j.bse.2009.05.003
Topic modeling for untargeted substructure exploration in metabolomics 10.1073/pnas.1608041113
Propagating annotations of molecular networks using in silico fragmentation 10.1371/journal.pcbi.1006089
Did a plant-herbivore arms race drive chemical diversity in Euphorbia? 10.1101/323014
Automatic Compound Annotation from Mass Spectrometry Data Using MAGMa. 10.5702/massspectrometry.S0033
Interactions of blacktea polyphenols with human gut microbiota: implications for gut and cardiovascular health 10.3945/ajcn.113.058263
Identification of a drimenol synthase and drimenol oxidase from Persicaria hydropiper, involved in the biosynthesis of insect deterrent drimanes 10.1111/tpj.13527
Enhanced Acylcarnitine Annotation in High-Resolution Mass Spectrometry Data: Fragmentation Analysis for the Classification and Annotation of Acylcarnitines 10.3389/fbioe.2015.00026
Rapid and sustained systemic circulation of conjugated gut microbiol catabolites after single-dose black tea extract consumption 10.1021/pr5001253
In Silico Prediction and Automatic LC–MSn Annotation of Green Tea Metabolites in Urine 10.1021/ac403875b
Unexpected differential metabolic responses of Campylobacter jejuni to the abundant presence of glutamate and fucose 10.1007/s11306-018-1438-5
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1101/463620
Deciphering complex metabolite mixtures by unsupervised and supervised substructure discovery and semi-automated annotation from MS/MS spectra 10.1101/491506
Accelerating metabolite identification in natural product research: toward an ideal combination of LC-HRMS/MS and NMR profiling, in silico databases and chemometrics 10.1021/acs.analchem.8b05112
Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages 10.1101/347716
Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings https://doi.org/10.1016/j.mam.2017.11.002
Metabolite Identification in Complex Mixtures Using Nuclear Magnetic Resonance Spectroscopy 10.1007/978-3-319-28275-6_6-2
Ms2lda.org: web-based topic modelling for substructure discovery in mass spectrometry 10.1093/bioinformatics/btx582
A comprehensive evaluation of the [2-14C](–)-epicatechin metabolome in rats https://doi.org/10.1016/j.freeradbiomed.2016.08.001
The food metabolome: a window over dietary exposure 10.3945/ajcn.113.076133
Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols 10.3945/ajcn.113.058958
Unsupervised Discovery and Comparison of Structural Families Across Multiple Samples in Untargeted Metabolomics 10.1021/acs.analchem.7b01391
A community-driven paired data platform to accelerate natural product mining by combining structural information from genomes and metabolomes 10.18174/FAIRdata2018.16286
Implementations of the chemical structural and compositional similarity metric in R and Python 10.1101/546150
Comprehensive mass spectrometry-guided phenotyping of plant specialized metabolites reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1111/tpj.14292
A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters 10.1186/s13104-019-4222-3
The Metabolomics Society—Current State of the Membership and Future Directions 10.3390/metabo9050089
Deciphering complex metabolite mixtures by unsupervised and supervised substructure discovery and semi-automated annotation from MS/MS spectra 10.1039/C8FD00235E
MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools 10.1101/654459
Substantial extracellular metabolic differences found between phylogenetically closely related probiotic and pathogenic strains of Escherichia coli 10.3389/fmicb.2019.00252
Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia l. 10.3389/fpls.2019.00846
Molnetenhancer: Enhanced molecular networks by integrating metabolome mining and annotation tools 10.3390/metabo9070144
In Silico Optimization of Mass Spectrometry Fragmentation Strategies in Metabolomics 10.3390/metabo9100219
MIBiG 2.0: a repository for biosynthetic gene clusters of known function 10.1093/nar/gkz882
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery 10.1021/acscentsci.9b00806
Mass spectrometry searches using MASST 10.1038/s41587-019-0375-9
Assessing specialized metabolite diversity of Alnus species by a digitized LC–MS/MS data analysis workflow 10.1016/j.phytochem.2020.112292
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication 10.1126/sciadv.aax6328
Chemically-informed Analyses of Metabolomics Mass Spectrometry Data with Qemistree 10.1101/2020.05.04.077636
Linking genomics and metabolomics to chart specialized metabolic diversity 10.1039/D0CS00162G
Reproducible molecular networking of untargeted mass spectrometry data using GNPS 10.1038/s41596-020-0317-5
Decomposing metabolite set activity levels with PALS 10.1101/2020.06.07.138974
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions 10.1101/2020.06.12.148205
Phenylpropane as an Alternative Dearomatizing Unit of Indoles: Discovery of Inaequalisines A and B Using Substructure-Informed Molecular Networking 10.1021/acs.orglett.0c02153
matchms - processing and similarity evaluation of mass spectrometry data 10.1101/2020.08.06.239244
Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships 10.1101/2020.08.11.245928
BiG-SLiCE: A Highly Scalable Tool Maps the Diversity of 1.2 Million Biosynthetic Gene Clusters 10.1101/2020.08.17.240838
matchms - processing and similarity evaluation of mass spectrometry data. 10.21105/joss.02411
ReDU: a framework to find and reanalyze public mass spectrometry data 10.1038/s41592-020-0916-7
Feature-based molecular networking in the GNPS analysis environment 10.1038/s41592-020-0933-6
Rapid Development of Improved Data-dependent Acquisition Strategies 10.1101/2020.09.11.293092
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree 10.1038/s41589-020-00677-3
Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data 10.1038/s41587-020-0700-3
The ant fungus garden acts as an external digestive system 10.1101/2020.11.18.389361
BiG-MAP: an automated pipeline to profile metabolic gene cluster abundance and expression in microbiomes 10.1101/2020.12.14.422671
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters 10.1093/gigascience/giaa154
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs 10.1371/journal.ppat.1008932
Comparative Metabologenomics Analysis of Polar Actinomycetes 10.3390/md19020103
Ranking Metabolite Sets by Their Activity Levels 10.3390/metabo11020103
Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships 10.1371/journal.pcbi.1008724
Rapid Development of Improved Data-Dependent Acquisition Strategies 10.1021/acs.analchem.0c03895
MS2DeepScore - a novel deep learning similarity measure for mass fragmentation spectrum comparisons 10.1101/2021.04.18.440324
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions 10.1371/journal.pcbi.1008920
Metabolomics-Guided Elucidation of Plant Abiotic Stress Responses in the 4IR Era: An Overview 10.3390/metabo11070445
Chemical Gradients of Plant Substrates in an Atta texana Fungus Garden 10.1128/mSystems.00601-21
Comprehensive Large-Scale Integrative Analysis of Omics Data To Accelerate Specialized Metabolite Discovery 10.1128/mSystems.00726-21
Sandosh Padmanabhan
Padmanabhan Sandosh
ORCID: 0000-0003-3869-5808
Validation of uromodulin as a candidate gene for human essential hypertension 10.1161/HYPERTENSIONAHA.113.01423
Response to effect of serum chloride on mortality in hypertensive patients 10.1161/HYPERTENSIONAHA.113.02926
NEDD4L in essential hypertension 10.1097/HJH.0000000000000105
Molecular genetic contributions to socioeconomic status and intelligence 10.1016/j.intell.2014.02.006
Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of european descent confirm known loci and reveal several novel associations 10.1093/hmg/ddt626
Family history of premature cardiovascular disease: Blood pressure control and long-term mortality outcomes in hypertensive patients 10.1093/eurheartj/eht539
Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients 10.1161/HYPERTENSIONAHA.113.00859
Serum chloride is an independent predictor of mortality in hypertensive patients 10.1161/HYPERTENSIONAHA.113.01793
Resting heart rate and outcomes in patients with cardiovascular disease: Where do we currently stand? 10.1111/j.1755-5922.2012.00321.x
Prospects for genetic risk prediction in hypertension 10.1161/HYPERTENSIONAHA.113.00948
Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes 10.1161/HYPERTENSIONAHA.111.00823
Long-term and ultra long-term blood pressure variability during follow-up and mortality in 14 522 patients with hypertension 10.1161/HYPERTENSIONAHA.113.01343
Heritability analyses show visit-to-visit blood pressure variability reflects different pathological phenotypes in younger and older adults: Evidence from UK twins 10.1097/HJH.0b013e32836523c1
Genomics of elite sporting performance: What little we know and necessary advances 10.1016/B978-0-12-407703-4.00004-9
Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide 10.1161/HYPERTENSIONAHA.111.00436
Emerging face of genetics, genomics and diabetes 10.1007/s13410-013-0164-9
Discontinuation of beta-blockers in cardiovascular disease: UK primary care cohort study 10.1016/j.ijcard.2012.06.116
Common polymorphisms in the CYP11B1 and CYP11B2 genes: Evidence for a digenic influence on hypertension 10.1161/HYPERTENSIONAHA.112.200741
Blood pressure response to patterns of weather fluctuations and effect on mortality 10.1161/HYPERTENSIONAHA.111.00686
Acetaminophen use and change in blood pressure in a hypertensive population 10.1097/HJH.0b013e328360f6f8
Hematocrit predicts long-term mortality in a nonlinear and sex-specific manner in hypertensive adults 10.1161/HYPERTENSIONAHA.112.191510
Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase 10.1161/HYPERTENSIONAHA.111.181990
Genetics and Hypertension: Is It Time to Change My Practice? 10.1016/j.cjca.2012.02.004
Genetically distinct subsets within ANCA-associated vasculitis 10.1056/NEJMoa1108735
Genetic basis of blood pressure and hypertension 10.1016/j.tig.2012.04.001
Copy-number disorders are a common cause of congenital kidney malformations 10.1016/j.ajhg.2012.10.007
Association between genetic variants on chromosome 15q25 locus and objective measures of Tobacco exposure 10.1093/jnci/djs191
Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy 10.1056/NEJMoa1009742
Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index 10.1093/ije/dyr077
Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy 10.1161/CIRCGENETICS.111.960203
Evaluation of how gene-job strain interaction affects blood pressure in the PAMELA study 10.1097/PSY.0b013e318212e0be
Association between ADRA1A gene and the metabolic syndrome: Candidate genes and functional counterpart in the PAMELA population 10.1097/HJH.0b013e328346d72c
The pharmacogenomics of anti-hypertensive therapy 10.3390/ph3061779
The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study 10.1097/HJH.0b013e32833594d7
Resting heart rate pattern during follow-up and mortality in hypertensive patients 10.1161/HYPERTENSIONAHA.109.144808
Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention 10.1093/eurheartj/ehp317
HLA has strongest association with IgA nephropathy in genome-wide analysis 10.1681/ASN.2010010076
Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension 10.1371/journal.pgen.1001177
Genome-wide association studies of hypertension: Light at the end of the tunnel 10.4061/2010/509581
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Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): Evidence from 5 independent studies with >15,000 participants 10.3945/ajcn.2010.29438
Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: Clinical evidence and pathophysiological mechanisms 10.1016/j.atherosclerosis.2010.01.029
Antihypertensive pharmacogenetics: Missed opportunity 10.1097/HJH.0b013e32833f2f56
Risks of socioeconomic deprivation on mortality in hypertensive patients 10.1097/HJH.0b013e328324ed58
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Functional genomics of the oxidative stress pathway 10.2174/157340207781386675
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Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study 10.1161/01.HYP.0000197947.62601.9d
Should diabetes be considered a coronary heart disease risk equivalent? Results from 25 years of follow-up in the Renfrew and Paisley survey 10.2337/diacare.28.7.1588
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The Y chromosome effect on blood pressure in two European populations 10.1161/hy0202.103413
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Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort 10.1161/HYPERTENSIONAHA.114.04945
Metabolomic Identification of a Novel Pathway of Blood Pressure Regulation Involving Hexadecanedioate 10.1161/HYPERTENSIONAHA.115.05544
TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives 10.1097/HJH.0000000000000541
Genetic and Molecular Aspects of Hypertension 10.1161/CIRCRESAHA.116.303647
The hidden hand of chloride in hypertension 10.1007/s00424-015-1690-8
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PTPRD gene associated with blood pressure response to atenolol and resistant hypertension 10.1097/HJH.0000000000000714
Longitudinal blood pressure control, long-term mortality, and predictive utility of serum liver enzymes and bilirubin in hypertensive patients 10.1161/HYPERTENSIONAHA.114.04915
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Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid 10.3945/ajcn.114.092981
Metabolomic study of carotid-femoral pulse-wave velocity in women 10.1097/HJH.0000000000000467
Pharmacogenomics and Stratified Medicine 10.1016/B978-0-12-386882-4.00001-3
Hypertension Pharmacogenomics 10.1016/B978-0-12-386882-4.00032-3
QTc and Sudden Cardiac Death 10.1016/B978-0-12-386882-4.00033-5
Genomics and Pharmacogenomics of Lipid-Lowering Therapies 10.1016/B978-0-12-386882-4.00031-1
Clinical Trials in Pharmacogenomics and Stratified Medicine 10.1016/B978-0-12-386882-4.00015-3
Pharmacokinetic Pharmacogenomics 10.1016/B978-0-12-386882-4.00017-7
Fundamentals of Complex Trait Genetics and Association Studies 10.1016/B978-0-12-386882-4.00012-8
Pharmacodynamic Pharmacogenomics 10.1016/B978-0-12-386882-4.00018-9
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Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers 10.1371/journal.pgen.1004799
Allopurinol initiation and change in blood pressure in older adults with hypertension 10.1161/HYPERTENSIONAHA.114.03953
Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension 10.1161/HYPERTENSIONAHA.114.03132
Genetics and hypertension: Which information for clinical practice 10.1007/978-88-470-2601-8_33
Insulin resistance: Genetic associations with depression and cognition in population based cohorts 10.1016/j.expneurol.2019.04.001
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 10.1038/s41588-019-0447-2
A catalog of genetic loci associated with kidney function from analyses of a million individuals. 10.1038/s41588-019-0407-x
May Measurement Month 2017: an analysis of blood pressure screening results from the United Kingdom and the Republic of Ireland-Europe. 10.1093/eurheartj/suz072
Cardiac Troponin T and Troponin I in the General Population. 10.1161/circulationaha.118.038529
Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines. 10.1186/s12199-019-0771-2
Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism. 10.12688/wellcomeopenres.13893.2
Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP. 10.1038/s41397-019-0067-3
Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study. 10.1136/openhrt-2018-000924
Necessity of Preventing Cardiovascular Disease by Smoke-Free Policies. 10.1161/JAHA.118.011120
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. 10.1038/s41588-018-0297-3
Rare loss of function variants in candidate genes and risk of colorectal cancer. 10.1007/s00439-018-1938-4
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. 10.1038/s41588-018-0205-x
Salt stress in the renal tubules is linked to TAL-specific expression of uromodulin and an upregulation of heat shock genes. 10.1152/physiolgenomics.00057.2018
Comparison between High-Sensitivity Cardiac Troponin T and Cardiac Troponin I in a Large General Population Cohort. 10.1373/clinchem.2018.292086
A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial. 10.1016/j.ahj.2018.05.006
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. 10.1038/s41467-018-04766-9
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. 10.1186/s13059-018-1457-6
Risk of Neuropsychiatric Adverse Effects of Lipid-Lowering Drugs: A Mendelian Randomization Study. 10.1093/ijnp/pyy060
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 10.1371/journal.pone.0198166
Multi-ethnic genome-wide association study for atrial fibrillation. 10.1038/s41588-018-0133-9
Recent Findings in the Genetics of Blood Pressure: How to Apply in Practice or Is a Moonshot Required? 10.1007/s11906-018-0863-1
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals. 10.1161/CIRCGEN.117.001758
Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Angina (CorMicA) stratified medicine clinical trial. 10.1016/j.ahj.2018.03.010
Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval. 10.1161/CIRCGEN.117.002037
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. 10.1016/S2213-8587(18)30071-8
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 10.1038/s41588-018-0082-3
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 10.1038/s41588-018-0050-y
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 10.1016/j.ajhg.2018.01.015
Age at Menarche and Cardiometabolic Health: A Sibling Analysis in the Scottish Family Health Study. 10.1161/JAHA.117.007780
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis. 10.1136/annrheumdis-2017-212372
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. 10.1038/ncomms16015
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 10.1038/s41588-017-0011-x
Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial. 10.1161/JAHA.117.006986
Exome-wide association study of plasma lipids in >300,000 individuals. 10.1038/ng.3977
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. 10.1161/CIRCGENETICS.117.001778
Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. 10.1038/ng1017-1558a
Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans. 10.1152/physrev.00035.2016
Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 10.1371/journal.pgen.1006972
Novel Urinary Peptidomic Classifier Predicts Incident Heart Failure. 10.1161/JAHA.116.005432
Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. 10.1038/ng0817-1286c
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. 10.1161/HYPERTENSIONAHA.117.09438
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. 10.1038/ng.3895
Unsupervised Discovery and Comparison of Structural Families Across Multiple Samples in Untargeted Metabolomics. 10.1021/acs.analchem.7b01391
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Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 10.1371/journal.pgen.1006528
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 10.1038/ncomms14977
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. 10.1038/ng.3841
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. 10.1038/ng.3843
Molecular pathways associated with blood pressure and hexadecanedioate levels. 10.1371/journal.pone.0175479
Discovery of novel heart rate-associated loci using the Exome Chip. 10.1093/hmg/ddx113
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants. 10.1186/s13073-017-0414-4
Chronic pain, depression and cardiovascular disease linked through a shared genetic predisposition: Analysis of a family-based cohort and twin study. 10.1371/journal.pone.0170653
Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting. 10.1161/CIRCULATIONAHA.116.024436
Genomics and Precision Medicine for Clinicians and Scientists in Hypertension. 10.1161/hypertensionaha.116.08252
Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder. 10.1016/j.biopsych.2016.12.012
Rare and low-frequency coding variants alter human adult height. 10.1038/nature21039
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. 10.1038/ng.3768
Urine Metabolomics in Hypertension Research. 10.1007/978-1-4939-6625-7_5
Methods to Assess Genetic Risk Prediction. 10.1007/978-1-4939-6625-7_2
A PROgramme of Lifestyle Intervention in Families for Cardiovascular risk reduction (PROLIFIC Study): design and rationale of a family based randomized controlled trial in individuals with family history of premature coronary heart disease. 10.1186/s12889-016-3928-6
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. 10.1681/ASN.2016020131
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. 10.1016/S2213-8587(16)30396-5
Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression. 10.1016/j.ebiom.2016.11.003
Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide. 10.1161/HYPERTENSIONAHA.116.08267
Development, Evaluation, and Comparison of Land Use Regression Modeling Methods to Estimate Residential Exposure to Nitrogen Dioxide in a Cohort Study. 10.1021/acs.est.6b02089
Monotherapy With Major Antihypertensive Drug Classes and Risk of Hospital Admissions for Mood Disorders. 10.1161/HYPERTENSIONAHA.116.08188
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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. 10.1038/ng.3654
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. 10.1016/j.biopsych.2016.05.010
Investigating shared aetiology between type 2 diabetes and major depressive disorder in a population based cohort. 10.1002/ajmg.b.32478
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A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder. 10.1016/j.biopsych.2016.04.017
An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group. 10.1002/gepi.21978
Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. 10.2337/db15-1671
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Allopurinol and Cardiovascular Outcomes in Adults With Hypertension. 10.1161/hypertensionaha.115.06344
No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes. 10.1371/journal.pone.0147330
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. 10.1038/nn.4205
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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. 10.1038/ncomms9658
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Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C. 10.1038/npjamd.2015.11
Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium. 10.1161/CIRCGENETICS.115.001225
Contrasting mortality risks among subgroups of treated hypertensive patients developing new-onset diabetes. 10.1093/eurheartj/ehv557
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Association between serum phosphate and calcium, long-term blood pressure, and mortality in treated hypertensive adults. 10.1097/hjh.0000000000000659
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. 10.1038/ng.3412
Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. 10.1093/ije/dyv074
Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. 10.1001/jamaneurol.2015.0582
The relationship between antihypertensive medications and mood disorders: analysis of linked healthcare data for 1.8 million patients 10.1101/19001719
Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction 10.1093/eurheartj/ehz915
Genomics of Blood Pressure and Hypertension: Extending the Mosaic Theory Toward Stratification 10.1016/j.cjca.2020.03.001
Genomic Determinants of Hypertension With a Focus on Metabolomics and the Gut Microbiome 10.1093/ajh/hpaa022
Dietary Influence on Systolic and Diastolic Blood Pressure in the TwinsUK Cohort 10.3390/nu12072130
Rationale and Design of the Genotype-Blinded Trial of Torasemide for the Treatment of Hypertension (BHF UMOD) 10.1093/ajh/hpaa166
Artificial Intelligence in Hypertension 10.1161/CIRCRESAHA.121.318106
Use and validation of text mining and cluster algorithms to derive insights from Corona Virus Disease-2019 (COVID-19) medical literature 10.1016/j.cmpbup.2021.100010
Variants associated with HHIP expression have sex-differential effects on lung function [version 2; peer review: 2 approved] 10.12688/wellcomeopenres.15846.2
Unravelling the tangled web of hypertension and cancer 10.1042/CS20200307