Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides
Liu, W.-T. Ng, J. Meluzzi, D. Bandeira, N. Gutierrez, M. Simmons, T.L. Schultz, A.W. Linington, R.G. Moore, B.S. Gerwick, W.H. Pevzner, P.A. Dorrestein, P.C.
Bradley Moore
Moore Bradley
ORCID: 0000-0002-4652-1253
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Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse 10.1021/acs.chemrev.6b00571
PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete 10.1021/acs.jnatprod.6b01121
Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols 10.1021/acs.jnatprod.6b00722
Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation 10.1002/cbic.201700090
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A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis 10.1038/nchem.2829
Function-related replacement of bacterial siderophore pathways 10.1038/ismej.2017.137
Enzymatic C−H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity 10.1002/ange.201705239
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Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis 10.1055/s-0036-1590919
Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster 10.1038/ja.2017.146
Biosynthesis of the Antibiotic Bicyclomycin in Soil and Pathogenic Bacteria 10.1021/acs.biochem.7b01204
Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics 10.1021/acs.est.8b00512
Enzymatic control of dioxygen binding and functionalization of the flavin cofactor. 10.1073/pnas.1801189115
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Broad-Host-Range Expression Reveals Native and Host Regulatory Elements That Influence Heterologous Antibiotic Production in Gram-Negative Bacteria. 10.1128/mbio.01291-17
Genomic insights into specialized metabolism in the marine actinomycete Salinispora. 10.1111/1462-2920.13867
Editorial: Are natural products the solution to antimicrobial resistance? 10.1039/c7np90026k
Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. 10.1038/nchembio.2330
Erratum: Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. 10.1038/nmicrobiol.2017.10
Effects of Actinomycete Secondary Metabolites on Sediment Microbial Communities. 10.1128/aem.02676-16
Family-wide Structural Characterization and Genomic Comparisons Decode the Diversity-oriented Biosynthesis of Thalassospiramides by Marine Proteobacteria. 10.1074/jbc.m116.756858
Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids. 10.1016/j.chembiol.2016.10.009
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. 10.1038/nmicrobiol.2016.197
Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. 10.1099/mic.0.000386
Enzymatic Reductive Dehalogenation Controls the Biosynthesis of Marine Bacterial Pyrroles. 10.1021/jacs.6b08512
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. 10.1038/nchembio.2157
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. 10.1073/pnas.1519695113
A Bacterial Quorum-Sensing Precursor Induces Mortality in the Marine Coccolithophore, Emiliania huxleyi. 10.3389/fmicb.2016.00059
Unusual flavoenzyme catalysis in marine bacteria. 10.1016/j.cbpa.2016.01.001
Recent advances in the biosynthesis of unusual polyketide synthase substrates. 10.1039/c5np00112a
A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis. 10.1002/anie.201508576
Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. 10.1021/acschembio.5b00658
Erratum: Reinvigorating natural product combinatorial biosynthesis with synthetic biology. 10.1038/nchembio1115-887a
Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins. 10.1021/acs.orglett.5b02113
Reinvigorating natural product combinatorial biosynthesis with synthetic biology. 10.1038/nchembio.1893
Minimum Information about a Biosynthetic Gene cluster. 10.1038/nchembio.1890
Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor. 10.1021/jacs.5b03983
Microbial and biochemical basis of a Fusarium wilt-suppressive soil. 10.1038/ismej.2015.95
Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase. 10.1002/cbic.201500177
The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. 10.1039/c4np00167b
Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. 10.1016/j.chembiol.2015.03.010
Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis. 10.1038/srep09383
Mechanism of action of thalassospiramides, a new class of calpain inhibitors. 10.1038/srep08783
Special issue in honor of William Fenical, a pioneer in marine natural products discovery and drug development. 10.1021/acs.jnatprod.5b00146
Digging for biosynthetic dark matter. 10.7554/elife.06453
Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry. 10.1021/es505440j
Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway. 10.1111/1462-2920.12669
Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin. 10.1021/np500664q
Correction to “Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases”. 10.1021/ja509209d
Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola. 10.1021/np500422d
Targeted capture and heterologous expression of the Pseudoalteromonas alterochromide gene cluster in Escherichia coli represents a promising natural product exploratory platform. 10.1021/sb500280q
A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins. 10.1002/anie.201405696
One-pot enzymatic synthesis of merochlorin A and B. 10.1002/anie.201405694
NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery. 10.1021/np500370c
Fungal polyketide engineering comes of age. 10.1073/pnas.1412946111
Enzymatic synthesis of polybrominated dioxins from the marine environment. 10.1021/cb5004338
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. 10.1038/nchembio.1564
Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. 10.1016/j.chembiol.2014.04.010
Automated genome mining of ribosomal peptide natural products. 10.1021/cb500199h
Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib). 10.1124/mol.114.092114
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. 10.1073/pnas.1319584111
Biosynthesis: Non-stick natural products. 10.1038/nchem.1828
Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine A. 10.1021/ja409520v
Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. 10.1021/cb400699p
Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. 10.1073/pnas.1315492110
Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. 10.1038/nature12643
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. 10.1038/ja.2013.99
Challenges and triumphs to genomics-based natural product discovery. 10.1007/s10295-013-1353-8
Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. 10.1021/bi400572a
MS/MS networking guided analysis of molecule and gene cluster families. 10.1073/pnas.1303471110
A tandem chemoenzymatic methylation by S-adenosyl-L-methionine. 10.1002/cbic.201300221
Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. 10.1002/cbic.201300147
Structures and comparative characterization of biosynthetic gene clusters for cyanosporasides, enediyne-derived natural products from marine actinomycetes. 10.1021/ja311065v
Biosynthetic multitasking facilitates thalassospiramide structural diversity in marine bacteria. 10.1021/ja3119674
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. 10.1039/c2np20085f
Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering. 10.1021/sb3001062
Molecular mechanisms of acquired proteasome inhibitor resistance. 10.1021/jm300434z
Mechanistic studies on CymD: a tryptophan reverse N-prenyltransferase. 10.1021/bi3009054
Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway. 10.1002/cbic.201200406
Editorial: structural aspects of biosynthesis themed issue. 10.1039/c2np90032g
Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. 10.1111/j.1574-6968.2012.02641.x
Primer on agar-based microbial imaging mass spectrometry. 10.1128/jb.00823-12
Flavoenzyme-catalyzed atropo-selective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis. 10.1021/ja305670f
Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. 10.1021/ja305665f
Mass spectral molecular networking of living microbial colonies. 10.1073/pnas.1203689109
Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. 10.1021/ja301735a
The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium. 10.1002/cbic.201200007
Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. 10.1111/j.1742-4658.2012.08517.x
Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. 10.1074/jbc.m112.349860
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. 10.1016/j.chembiol.2011.12.014
Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. 10.1016/j.chembiol.2011.10.014
Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. 10.1039/c1np00082a
Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus. 10.1021/ja2040877
A mass spectrometry-guided genome mining approach for natural product peptidogenomics. 10.1038/nchembio.684
Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. 10.1021/cb2002544
Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. 10.1021/ja205655w
Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. 10.1002/anie.201101225
Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. 10.1016/j.bmc.2011.04.024
Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. 10.1128/aem.00038-11
A stereoselective vanadium-dependent chloroperoxidase in bacterial antibiotic biosynthesis. 10.1021/ja201088k
Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. 10.1021/ja109226s
The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. 10.1002/cbic.201000564
A sea of biosynthesis: marine natural products meet the molecular age. 10.1039/c0np90032j
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. 10.1021/ja108399b
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics. 10.1002/anie.201000728
Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites. 10.1021/bi101457h
Shared biosynthesis of the saliniketals and rifamycins in Salinispora arenicola is controlled by the sare1259-encoded cytochrome P450. 10.1021/ja105891a
Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling. 10.1074/jbc.m110.153833
Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. 10.1021/ja102751h
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Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide. 10.1021/np900719u
Functional characterization of the cyclomarin/cyclomarazine prenyltransferase CymD directs the biosynthesis of unnatural cyclic peptides. 10.1021/np9006876
Total (bio)synthesis: strategies of nature and of chemists. 10.1007/128_2010_79
Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. 10.1021/jm901098m
Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62). 10.1002/cbic.200900369
Genomic basis for natural product biosynthetic diversity in the actinomycetes. 10.1039/b817069j
Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity. 10.1021/ja9042824
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. 10.1073/pnas.0901237106
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. 10.1021/ac900114t
Chasing the treasures of the sea - bacterial marine natural products. 10.1016/j.mib.2009.05.002
Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. 10.1038/ismej.2009.58
Exploring the chemistry and biology of vanadium-dependent haloperoxidases. 10.1074/jbc.r109.001602
Alkaloid biosynthesis takes root. 10.1038/nchembio0309-140
In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides. 10.1021/np800598t
Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone. 10.1002/anie.200805140
S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. 10.1002/cbic.200800341
Probing the compatibility of type II ketosynthase-carrier protein partners. 10.1002/cbic.200800198
Advances in and applications of proteasome inhibitors. 10.1016/j.cbpa.2008.06.033
Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. 10.1021/ja8029398
Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. 10.1021/ja711188x
Unraveling the biosynthesis of the sporolide cyclohexenone building block. 10.1021/ja710488m
Extending the biosynthetic repertoire in ribosomal peptide assembly. 10.1002/anie.200803868
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. 10.1002/anie.200800177
Discovery and characterization of a marine bacterial SAM-dependent chlorinase. 10.1038/nchembio.2007.56
Enzymatic total synthesis of enterocin polyketides. 10.1038/nchembio.2007.22
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. 10.1073/pnas.0700962104
Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. 10.1074/jbc.m611046200
Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. 10.1021/ol063102o
Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. 10.1021/bi061774g
Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. 10.1016/j.chembiol.2006.11.011
Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. 10.1021/ja065247w
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. 10.1038/nchembio811
Biosynthesis of marine natural products: macroorganisms (Part B). 10.1039/b508781n
Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase. 10.1021/cb500007v
Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism. 10.1021/ja0559707
Biosynthesis of marine natural products: microorganisms (Part A). 10.1039/b404737k
Biochemical characterization of a prokaryotic phenylalanine ammonia lyase. 10.1128/jb.187.12.4286-4289.2005
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. 10.1074/jbc.m410933200
Exploiting marine actinomycete biosynthetic pathways for drug discovery. 10.1007/s10482-004-6541-0
EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions. 10.1073/pnas.0405508101
Engineered biosynthesis of phenyl-substituted polyketides. 10.1002/cbic.200400007
Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase. 10.1021/np0499564
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. 10.1074/jbc.m406567200
Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction. 10.1016/j.chembiol.2004.03.018
Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization. 10.1016/j.gene.2003.09.034
Biosynthesis and structural revision of neomarinone. 10.1021/ol035748b
Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). 10.1007/s10295-003-0075-8
Mutasynthesis of enterocin and wailupemycin analogues. 10.1021/ja035973o
Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224. 10.1016/s0378-1119(03)00587-0
Characterization of benzoyl coenzyme A biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus". 10.1128/jb.185.2.399-404.2003
Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. 10.1021/np020230m
Molecular evidence for a uniform microbial community in sponges from different oceans. 10.1128/aem.68.9.4431-4440.2002
Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene. 10.1074/jbc.m204171200
Mutational analysis of the enterocin favorskii biosynthetic rearrangement. 10.1021/ol0255155
Biosynthesis and attachment of novel bacterial polyketide synthase starter units. 10.1039/b003939j
A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation. 10.1002/1439-7633(20011001)2:10<784::aid-cbic784>;2-k
Discovery of a new bacterial polyketide biosynthetic pathway. 10.1002/1439-7633(20010105)2:1<35::aid-cbic35>;2-t
Engineering biodiversity with type II polyketide synthase genes. 10.1023/a:1010273224820
Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. 10.1016/s1074-5521(00)00044-2
Biosynthesis of marine natural products: microorganisms and macroalgae. 10.1039/a805873c
Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. 10.1073/pnas.96.16.9051
Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes. 10.1073/pnas.96.7.3622
Biosynthetic Studies of omega-Cycloheptyl Fatty Acids in Alicyclobacillus cycloheptanicus. Formation of Cycloheptanecarboxylic Acid from Phenylacetic Acid. 10.1021/jo962402o
Oleic Acid and Its Positional Isomer, cis-Vaccinic Acid, in the Appendix of Sauromatum guttatum during Anthesis. 10.1104/pp.107.4.1433
Three new omega-cycloheptyl fatty acids from Alicyclobacillus cycloheptanicus and their biosynthetic interrelationships. 10.1021/np50118a019
Biosynthetic studies on the origin of the cyclohexanecarboxylic acid moiety of ansatrienin A and omega-cyclohexyl fatty acids. 10.1021/np50105a008
Correction to Organohalogens Naturally Biosynthesized in Marine Environments and Produced As Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics 10.1021/acs.est.8b03174
Pangenomic comparison of globally distributed Poribacteria associated with sponge hosts and marine particles 10.1038/s41396-018-0292-9
Structural Elucidation of Trace Components Combining GC/MS, GC/IR, DFT-Calculation and Synthesis-Salinilactones, Unprecedented Bicyclic Lactones from Salinispora Bacteria 10.1002/anie.201807923
Strukturaufklärung von Spurenkomponenten durch Kombination von GC/MS, GC/IR, DFT-Simulationen und Synthese - Salinilactone, neuartige bicyclische Lactone aus Salinispora Bakterien 10.1002/ange.201807923
The chemical cue tetrabromopyrrole induces rapid cellular stress and mortality in phytoplankton 10.1038/s41598-018-33945-3
Total Enzyme Syntheses of Napyradiomycins A1 and B1 10.1021/jacs.8b10134
Insights into Thiotemplated Pyrrole Biosynthesis Gained from the Crystal Structure of Flavin-Dependent Oxidase in Complex with Carrier Protein 10.1021/acs.biochem.8b01177
Enzymatic Cascade Reactions in Biosynthesis 10.1002/anie.201807844
Enzymkaskadenreaktionen in der Biosynthese 10.1002/ange.201807844
Avant-garde assembly-line biosynthesis expands diversity of cyclic lipodepsipeptide products 10.1101/560987
Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom 10.1126/science.aau0382
Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives 10.1039/C8OB03109F
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid 10.1002/anie.201902910
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid 10.1002/ange.201902910
Biosynthesis of l ‐4‐Chlorokynurenine, an Antidepressant Prodrug and a Non‐Proteinogenic Amino Acid Found in Lipopeptide Antibiotics 10.1002/anie.201901571
Biosynthesis of l ‐4‐Chlorokynurenine, an Antidepressant Prodrug and a Non‐Proteinogenic Amino Acid Found in Lipopeptide Antibiotics 10.1002/ange.201901571
Comparative Genomics of Cyanobacterial Symbionts Reveals Distinct, Specialized Metabolism in Tropical Dysideidae Sponges 10.1128/mBio.00821-19
Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase 10.1021/acs.biochem.9b00318
Genetic platforms for heterologous expression of microbial natural products 10.1039/C9NP00025A
Cariogenic Streptococcus mutans produces strain-specific antibiotics that impair commensal colonization 10.1101/755025
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage 10.1038/s41557-019-0317-7
Pass-back chain extension expands multimodular assembly line biosynthesis 10.1038/s41589-019-0385-4
Cariogenic Streptococcus mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization 10.1021/acsinfecdis.9b00365
Algal Neurotoxin Biosynthesis Repurposes the Terpene Cyclase Structural Fold Into an N-prenyltransferase 10.1101/2020.03.31.014811
Nonlinear Biosynthetic Assembly of Alpiniamide by a Hybrid cis/trans-AT PKS-NRPS 10.1021/acschembio.0c00081
Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into anN-prenyltransferase 10.1073/pnas.2001325117
Comparative Genomics and Metabolomics in the Genus Nocardia 10.1128/mSystems.00125-20
Co-Occurrence of Enzyme Domains Guides the Discovery of an Oxazolone Synthetase 10.1101/2020.06.11.147165
Meroterpenoid natural products from Streptomyces bacteria – the evolution of chemoenzymatic syntheses 10.1039/D0NP00018C
Site-Directed Mutagenesis of Large Biosynthetic Gene Clusters via Oligonucleotide Recombineering and CRISPR/Cas9 Targeting 10.1021/acssynbio.0c00265
Biosynthesis of marine toxins 10.1016/j.cbpa.2020.06.009
Genetic examination of the marine bacterium Pseudoalteromonas luteoviolacea and effects of its metamorphosis‐inducing factors 10.1111/1462-2920.15211
Enzymes in natural product total synthesis 10.1039/D0NP90038A
Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products 10.1101/2020.10.11.335315
Phylogenetic analysis of the salinipostin γ-butyrolactone gene cluster uncovers new potential for bacterial signaling-molecule diversity 10.1101/2020.10.16.342204
Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products 10.1021/acschembio.0c00824
Discovery and Biosynthesis of Tetrachlorizine Reveals Enzymatic Benzylic Dehydrogenation via an ortho-Quinone Methide 10.1021/jacs.0c12415
Cryptic halogenation reactions in natural product biosynthesis 10.1039/D1NP00010A
Phylogenetic analysis of the salinipostin γ-butyrolactone gene cluster uncovers new potential for bacterial signalling-molecule diversity 10.1099/mgen.0.000568
Mining genomes to illuminate the specialized chemistry of life 10.1038/s41576-021-00363-7
Co-occurrence of enzyme domains guides the discovery of an oxazolone synthetase 10.1038/s41589-021-00808-4
Marcelino Gutierrez
Gutierrez Marcelino
ORCID: 0000-0003-1423-3772
Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea 10.3390/molecules21060819
Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants 10.1038/s41598-017-05515-6
Antimicrobial‐producing Pseudoalteromonas from the marine environment of Panama shows a high phylogenetic diversity and clonal structure 10.1002/jobm.201800087
Imaging Mass Spectrometry of a Coral Microbe Interaction with Fungi 10.1007/s10886-013-0320-1
Leptolide, a new furanocembranolide diterpene from Leptogorgia alba 10.1021/np049745z
Cannabinomimetic lipid from a marine cyanobacterium 10.1021/np200610t
Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula 10.1021/jo900578j
Antiprotozoal activity against Plasmodium falciparum and Trypanosoma cruzi of aeroplysinin-1 isolated from the new sponge Aplysina chiriquensis 10.1080/13880200500406503
Antiplasmodial activity of bacilosarcin A isolated from the octocoral-associated bacterium Bacillus sp. collected in Panama 10.4103/0975-7406.92739
Antitrypanosomal alkaloids from the marine bacterium Bacillus pumilus 10.3390/molecules170911146
L-Galactose as a natural product: Isolation from a marine octocoral of the first α-L-galactosyl saponin 10.1016/j.tetlet.2004.08.170
MS/MS networking guided analysis of molecule and gene cluster families 10.1073/pnas.1303471110
Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new Guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida 10.1021/np800121a
seco-briarellinone and briarellin S, two new eunicellin-based diterpenoids from the panamanian octocoral Briareum asbestinum 10.3390/md10112608
Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034
Antiplasmodial metabolites isolated from the marine octocoral Muricea austera 10.1021/np060007f
A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages 10.1371/journal.pone.0084107
Microbiota of healthy corals are active against fungi in a light-dependent manner 10.1021/cb500432j
Toxins and pharmacologically active compounds from species of the family Bufonidae (Amphibia, Anura) 10.1016/j.jep.2016.12.021
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides 10.1021/ac900114t
Malyngolide dimer, a bioactive symmetric cyclodepside from the panamanian marine cyanobacterium lyngbya majuscula 10.1021/np9005184
Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-β Aggregation in Alzheimer's Disease 10.3233/JAD-170071
Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum 10.3390/molecules23092179
A Marine Diterpenoid Modulates the Proteasome Activity in Murine Macrophages Stimulated with LPS 10.3390/biom8040109
Viscosin-like lipopeptides from frog skin bacteria inhibit Aspergillus fumigatus and Batrachochytrium dendrobatidis detected by imaging mass spectrometry and molecular networking 10.1038/s41598-019-39583-7
Antiparasitic Compounds from the Panamanian Marine Bacterium Pseudomonas aeruginosa
Fungus-Growing Ant’s Microbial Interaction of Streptomyces sp. and Escovopsis sp. through Molecular Networking and MALDI Imaging
New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum 10.3390/md18020084
Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién 10.1371/journal.pone.0214193
19-Hydroxy-bufalin, a major bufadienolide isolated from the parotoid gland secretions of the Panamanian endemic toad Rhinella centralis (Bufonidae), inhibits the growth of Trypanosoma cruzi 10.1016/j.toxicon.2020.02.009
Reproducible molecular networking of untargeted mass spectrometry data using GNPS 10.1038/s41596-020-0317-5
Genome Mining, Microbial Interactions, and Molecular Networking Reveals New Dibromoalterochromides from Strains of Pseudoalteromonas of Coiba National Park-Panama 10.3390/md18090456
Metabolites from Microbes Isolated from the Skin of the Panamanian Rocket Frog Colostethus panamansis (Anura: Dendrobatidae) 10.3390/metabo10100406
Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens 10.3390/antibiotics9120843
Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327 10.3390/antibiotics9120923
Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi 10.3390/molecules26144217
Roger Linington
Linington Roger / Roger G. Linington
ORCID: 0000-0003-1818-4971
Biofilm Formation and Detachment in Gram-Negative Pathogens Is Modulated by Select Bile Acids. 10.1371/journal.pone.0149603
The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes. 10.1074/jbc.M115.673210
Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries. 10.1073/pnas.1507743112
Phenotype-Guided Natural Products Discovery Using Cytological Profiling. 10.1021/acs.jnatprod.5b00455
Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. 10.1021/acschembio.5b00308
Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. 10.1021/acs.joc.5b01264
Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms. 10.1039/c5ob01134e
Living in the matrix: assembly and control of Vibrio cholerae biofilms. 10.1038/nrmicro3433
Connecting phenotype and chemotype: high-content discovery strategies for natural products research. 10.1021/acs.jnatprod.5b00017
Salinipostins A-K, long-chain bicyclic phosphotriesters as a potent and selective antimalarial chemotype. 10.1021/jo5024409
Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism. 10.1021/ol503349y
Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae. 10.1039/c4cc07003h
Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis. 10.1021/np500727g
A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. 10.1016/j.cell.2014.08.032
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. 10.1016/j.cell.2014.06.034
Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity. 10.1371/journal.pone.0084549
An NF-κB-based high-throughput screen identifies piericidins as inhibitors of the Yersinia pseudotuberculosis type III secretion system. 10.1128/AAC.02025-13
Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa. 10.1128/AAC.01781-13
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. 10.1038/ja.2013.99
Discovery and biological characterization of the auromomycin chromophore as an inhibitor of biofilm formation in Vibrio cholerae. 10.1002/cbic.201300131
Molecular networking as a dereplication strategy. 10.1021/np400413s
Mechanism of action-based classification of antibiotics using high-content bacterial image analysis. 10.1039/c3mb70027e
Development of quinoline-based disruptors of biofilm formation against Vibrio cholerae. 10.1021/ol400150z
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. 10.1021/np300834q
"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening. 10.1016/j.chembiol.2012.12.007
Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics. 10.1016/j.chembiol.2012.09.014
Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP. 10.1016/j.chembiol.2012.08.014
Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness. 10.1371/journal.pone.0046172
Chemical inhibitors of the type three secretion system: disarming bacterial pathogens. 10.1128/AAC.00975-12
Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products. 10.1371/journal.pone.0035398
Total synthesis, stereochemical assignment, and antimalarial activity of gallinamide A. 10.1002/chem.201102538
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. 10.1038/nchembio.664
Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants. 10.1016/j.bmc.2011.07.017
Versatile method for the detection of covalently bound substrates on solid supports by DART mass spectrometry. 10.1021/ol201404v
Expedient synthesis of α,α-dimethyl-β-hydroxy carbonyl scaffolds via Evans' aldol reaction with a tertiary enolate. 10.1016/j.tetlet.2011.03.126
An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae. 10.1039/c0mb00276c
Identification and characterization of a phosphodiesterase that inversely regulates motility and biofilm formation in Vibrio cholerae. 10.1128/JB.00209-10
Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. 10.1021/jm100265s
Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity. 10.1021/np900622m
Dereplication and de novo sequencing of nonribosomal peptides. 10.1038/nmeth.1350
New innovations for an old infection: antimalarial lead discovery from marine natural products during the period 2003-2008. 10.4155/fmc.09.56
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. 10.1021/ac900114t
Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. 10.1021/np8003529
Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp. 10.1021/np070280x
Linking bioprospecting with sustainable development and conservation: the Panama case 10.1007/s10531-007-9214-2
Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. 10.1021/np0700772
Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp. 10.1021/np0605790
Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia. 10.1021/np050192h
Stereochemical assignment in acyclic lipids across long distance by circular dichroism: absolute stereochemistry of the aglycone of caminoside A. 10.1002/anie.200461158
Latonduines A and B, new alkaloids isolated from the marine sponge Stylissa carteri: structure elucidation, synthesis, and biogenetic implications. 10.1021/ol034950b
Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia. 10.1021/ol0268337
Total Synthesis of Glycinocins A-C. 10.1021/acs.joc.7b01959
Total Synthesis of Skyllamycins A-C. 10.1002/chem.201704277
Data-analysis strategies for image-based cell profiling. 10.1038/nmeth.4397
Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high. 10.1073/pnas.1711139114
Retrospective analysis of natural products provides insights for future discovery trends. 10.1073/pnas.1614680114
Special Issue in Honor of Professor Phil Crews. 10.1021/acs.jnatprod.7b00161
Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. 10.1038/ncomms14414
Piericidin A1 Blocks Yersinia Ysc Type III Secretion System Needle Assembly. 10.1128/msphere.00030-17
Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure-activity relationship of anabaenopeptin protease inhibitors. 10.1016/j.bmcl.2016.09.008
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
Erratum for Duncan et al., An NF-κB-Based High-Throughput Screen Identifies Piericidins as Inhibitors of the Yersinia pseudotuberculosis Type III Secretion System. 10.1128/aac.00973-16
Image-Based Screening Approaches to Natural Products Discovery 10.1002/9781118794623.ch20
De Novo Sequencing of Nonribosomal Peptides 10.1007/978-3-540-78839-3_16
De Novo terpenoid biosynthesis by the dendronotid nudibranch Melibe leonina 10.1007/pl00012669
The bioactive lipid (S)-sebastenoic acid impacts motility and dispersion in Vibrio cholerae 10.1139/cjc-2017-0334
Synthetic Studies Toward the Skyllamycins: Total Synthesis and Generation of Simplified Analogues 10.1021/acs.joc.8b00898
Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile. 10.1021/acsinfecdis.7b00105
A selective genome-guided method for environmental Burkholderia isolation. 10.1007/s10295-018-02121-x
Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source. 10.1002/anie.201805673
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. 10.1039/c7np00064b
Synthesis and evaluation of analogues of the glycinocin family of calcium-dependent antibiotics. 10.1039/c8ob01268g
Maculatic Acids-Sex Attractant Pheromone Components of Bald-Faced Hornets. 10.1002/anie.201804666
Cutibacterium acnes antibiotic production shapes niche competition in the human skin microbiome 10.1101/594010
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. 10.1039/c8np90041h
Problems in Organic Structure Determination 10.1201/b19329
MIBiG 2.0: a repository for biosynthetic gene clusters of known function 10.1093/nar/gkz882
High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling 10.1101/748129
Isolation, Structure Elucidation, and Total Synthesis of Dolichovespulide, a Sesquiterpene from Dolichovespula Yellowjackets 10.1021/acs.jnatprod.9b00238
Targeting tRNA-Synthetase Interactions towards Novel Therapeutic Discovery Against Eukaryotic Pathogens 10.1101/711697
New methods for isolation and structure determination of natural products 10.1039/c9np90023c
Development of a Custom MALDI-TOF Mass Spectrometric Database for Identification of Environmental Burkholderia and Related Genera. 10.1128/aem.00354-20
Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens. 10.1371/journal.pntd.0007983
The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites. 10.1016/j.chembiol.2020.01.001
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery. 10.1021/acscentsci.9b00806
A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles 10.1126/scitranslmed.aay5445
Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products. 10.1021/acschembio.0c00824
Microbial natural product databases: moving forward in the multi-omics era. 10.1039/d0np00053a