Strategies to dissect parasite proteomes
Parasitology, 2012-8
Richard Burchmore
Burchmore Richard
ORCID: 0000-0003-1663-9004
Integration of proteomics and metabolomics to elucidate metabolic adaptation in Leishmania 10.1016/j.jprot.2016.12.009
Proteomics at the host: pathogen interface 10.3920/978-90-8686-776-9_11
Neuroproteomics 10.1586/epr.10.17
Strategies to dissect parasite proteomes 10.1017/s0031182011002368
Animal Parasitology and Proteomics 10.1002/9780470960660.ch12
Mapping pathways to drug resistance with proteomics 10.1586/14789450.2014.871497
Chemotherapy of Human African Trypanosomiasis 10.2174/1381612023396159
Proteomic insights into parasite biology 10.1017/s0031182012000947
After the genome—where next? 10.1016/s0166-6851(01)00364-4
Leishmania mexicana: promastigotes migrate through osmotic gradients 10.1016/s0014-4894(03)00031-6
Differential in-gel electrophoresis (DIGE) analysis of human bone marrow osteoprogenitor cell contact guidance 10.1016/j.actbio.2008.11.001
Biomarkers of winter disease in gilthead seabream: a proteomics approach 10.3920/978-90-8686-776-9_45
Parasites in the brain? The search for sleeping sickness biomarkers 10.1586/eri.12.124
Sixth Exploratory Measurement Science Group symposium 10.1586/epr.09.88
Identification of anti-infective targets through comparative proteomics 10.1586/14787210.4.2.163
Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis 10.1016/
Alteration in mononuclear cell subpopulations in dogs immunized with gentamicin-attenuated Leishmania infantum 10.1017/s0031182012001187
Proteomics as a tool to explore human milk in health and disease 10.1016/j.jprot.2013.04.008
Functional analysis of Trypanosoma brucei PUF1 10.1016/j.molbiopara.2006.09.007
2D-DIGE proteomic analysis of mesenchymal stem cell cultured on the elasticity-tunable hydrogels 10.1247/csf.12012
Pentose phosphate metabolism in Leishmania mexicana 10.1016/s0166-6851(03)00173-7
The trypanosomiases 10.1016/s0140-6736(03)14694-6
Glucose transport in amastigotes and promastigotes of Leishmania mexicana mexicana 10.1016/0166-6851(95)02485-9
Life in vacuoles – nutrient acquisition by Leishmania amastigotes 10.1016/s0020-7519(01)00259-4
Proteomics in biomarker detection and monitoring of pancreas disease (PD) in atlantic salmon (Salmo salar) 10.3920/978-90-8686-751-6_20
A proteomic analysis of canine serum during the course of babesiosis 10.3920/978-90-8686-776-9_36
The effect of microbial challenge on the intestinal proteome of broiler chickens 10.3920/978-90-8686-776-9_38
The Optimization of Protocols for Proteome Difference Gel Electrophoresis (DiGE) Analysis of Preneoplastic Skin 10.1021/pr0606878
The role of microtopography in cellular mechanotransduction 10.1016/j.biomaterials.2011.11.047
Drug resistance in human African trypanosomiasis 10.2217/fmb.11.88
Research Highlights 10.2217/17435889.3.4.411
Preventing and troubleshooting artefacts in saturation labelled fluorescence 2-D difference gel electrophoresis (saturation DiGE) 10.1002/pmic.201100135
Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy 10.1016/j.femsre.2005.03.004
Identification of ORC1/CDC6-Interacting Factors in Trypanosoma brucei Reveals Critical Features of Origin Recognition Complex Architecture 10.1371/journal.pone.0032674
Pulse of α-2-macroglobulin and lipocalin-1 in the pregnant uterus of European polecats (Mustela putorius) at the time of implantation 10.1101/088609
Effects of a surface topography composite with puerariae radix on human STRO-1-positive stem cells 10.1016/j.actbio.2010.02.038
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test 10.1016/s0140-6736(05)66793-1
Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling 10.1016/j.biomaterials.2009.05.040
Enhanced dietary formulation to mitigate winter thermal stress in gilthead sea bream (Sparus aurata): a 2D-DIGE plasma proteome study 10.1007/s10695-016-0315-2
Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection 10.1155/2013/283619
Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni 10.1017/s0031182011000412
A plethora of targets, a paucity of drugs: progress towards the development of novel chemotherapies for human African trypanosomiasis 10.1586/14787210.1.1.157
Yersinia ruckeri Isolates Recovered from Diseased Atlantic Salmon (Salmo salar) in Scotland Are More Diverse than Those from Rainbow Trout (Oncorhynchus mykiss) and Represent Distinct Subpopulations 10.1128/aem.01173-16
Trypanosoma cruzi contains two galactokinases; molecular and biochemical characterization 10.1016/j.parint.2016.06.008
Prolonged transition time between colostrum and mature milk in a bear, the giant panda,Ailuropoda melanoleuca 10.1098/rsos.150395
Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome 10.1007/s11306-014-0770-7
Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism 10.1016/j.jprot.2011.11.018
A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase 10.1016/j.jprot.2007.11.002
Identification of developmentally-regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes 10.1016/j.molbiopara.2006.01.008
Gentamicin-attenuated Leishmania infantum: A clinicopathological study in dogs 10.1016/j.vetimm.2008.12.002
A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes 10.1016/j.molbiopara.2010.07.002
Corrigendum to “Functional analysis of Trypanosoma brucei PUF1” [Mol. Biochem. Parasitol. 150 (2006) 340–349] 10.1016/j.molbiopara.2009.09.003
The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog 10.1007/s12192-013-0457-4
Identification of immunogenic proteins associated with protection against haemorrhagic septicaemia after vaccination of calves with a live-attenuated aroA derivative of Pasteurella multocida B:2 10.1016/j.rvsc.2009.01.007
‘Transient’ genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana 10.1111/mmi.12106
Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation 10.1186/1471-2105-13-63
Identification of serum biomarkers in dogs naturally infected with Babesia canis canis using a proteomic approach 10.1186/1746-6148-10-111
Agarose gel serum protein electrophoresis in cats with and without lymphoma and preliminary results of tandem mass fingerprinting analysis 10.1111/j.1939-165x.2011.00310.x
Characterisation of the plasma membrane subproteome of bloodstream formTrypanosoma brucei 10.1002/pmic.200700607
A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes 10.1371/journal.ppat.1001204
Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei 10.1371/journal.pntd.0001618
Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics 10.1039/c6mb00239k
Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 3. Untargeted metabolomics 10.1039/c6mb00289g
Gentamicin-Attenuated Leishmania infantum Vaccine: Protection of Dogs against Canine Visceral Leishmaniosis in Endemic Area of Southeast of Iran 10.1371/journal.pntd.0002757
Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei 10.1371/journal.pone.0067327
Praziquantel Treatment of Individuals Exposed toSchistosoma haematobiumEnhances Serological Recognition of Defined Parasite Antigens 10.1086/432553
Age‐Related and Infection Intensity–Related Shifts in Antibody Recognition of Defined Protein Antigens in a Schistosome‐Exposed Population 10.1086/589511
Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei 10.1371/journal.pcbi.1003371
A proteomic approach to assess the host response in gills of farmed Atlantic salmon Salmo salar L. affected by amoebic gill disease 10.1016/j.aquaculture.2016.12.009
A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway 10.1101/gad.570310
Biochemistry and molecular genetics of Leishmania glucose transporters 10.1017/s0031182000075740
Protein Expression of STRO-1 Cells in Response to Different Topographic Features 10.4061/2011/534603
Differential Regulation of Multiple Glucose Transporter Genes in Leishmania mexicana 10.1074/jbc.273.44.29118
Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes 10.1073/pnas.170153097
41 Vascular protein oxidation and redox proteomics in human hypertension 10.1136/heartjnl-2015-308734.41
Sleeping sickness and the brain 10.1007/s00018-002-8472-0
Hexose Transport in Asexual Stages of Plasmodium falciparum and Kinetoplastidae 10.1016/s0169-4758(00)01762-2
The plasma proteome and acute phase proteins of broiler chickens with gait abnormalities 10.3920/978-90-8686-751-6_42
Dogs vaccinated with gentamicin-attenuated Leishmania infantum or infected with wild-type parasite can be distinguished by Western blotting 10.1111/pim.12108
Fluorescence two-dimensional difference gel electrophoresis for biomaterial applications 10.1098/rsif.2009.0177.focus
Proteomic analysis of human osteoprogenitor response to disordered nanotopography 10.1098/rsif.2008.0447
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast 10.1074/jbc.m116.714972
Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis 10.1016/j.molbiopara.2012.03.002
The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control 10.1111/mmi.12351
The metabolic enzyme AdhE controls the virulence ofEscherichia coli O157:H7 10.1111/mmi.12651
Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 2. Label-free relative quantitative proteomics 10.1039/c6mb00290k
Structure of protease-cleavedEscherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment 10.1107/s1399004715008548
Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei 10.1128/ec.2.5.1003-1008.2003
Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta 10.1017/s0031182010000028
Vaccination with Recombinant Leishmania donovani Gamma-Glutamylcysteine Synthetase Fusion Protein Protects Against L. donovani Infection 10.1645/ge-2360.1
Multiple Genetic Mechanisms Lead to Loss of Functional TbAT1 Expression in Drug-Resistant Trypanosomes 10.1128/ec.00200-09
A Glucose Transporter Can Mediate Ribose Uptake: DEFINITION OF RESIDUES THAT CONFER SUBSTRATE SPECIFICITY IN A SUGAR TRANSPORTER 10.1074/jbc.m110.106815
Trypanocidal Furamidine Analogues: Influence of Pyridine Nitrogens on Trypanocidal Activity, Transport Kinetics, and Resistance Patterns 10.1128/aac.01551-10
Outer Membrane Protein A of Bovine and Ovine Isolates of Mannheimia haemolytica Is Surface Exposed and Contains Host Species-Specific Epitopes 10.1128/iai.05469-11
The Trypanocide Diminazene Aceturate Is Accumulated Predominantly through the TbAT1 Purine Transporter: Additional Insights on Diamidine Resistance in African Trypanosomes 10.1128/aac.48.5.1515-1519.2004
Differential proteomics evaluation of osteoprogenitor growth on microgrooved surfaces using bioreactor culture 10.1016/j.cbpa.2007.01.420
Changes in the serum proteome of canine lymphoma identified by electrophoresis and mass spectrometry 10.1016/j.tvjl.2012.12.010
Characterisation of the normal canine serum proteome using a novel electrophoretic technique combined with mass spectrometry 10.1016/j.tvjl.2012.12.011
Enhancing the egg's natural defence against bacterial penetration by increasing cuticle deposition 10.1111/age.12071
Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4 10.1111/j.1365-3024.2010.01270.x
Gentamicin-attenuated Leishmania infantum: cellular immunity production and protection of dogs against experimental canine leishmaniasis 10.1111/j.1365-3024.2010.01237.x
Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules 10.1002/rcm.3564
A glucose transporter can mediate ribose uptake.: DEFINITION OF RESIDUES THAT CONFER SUBSTRATE SPECIFICITY IN A SUGAR TRANSPORTER. 10.1074/jbc.a110.106815
Loss of the High-Affinity Pentamidine Transporter Is Responsible for High Levels of Cross-Resistance between Arsenical and Diamidine Drugs in African Trypanosomes 10.1124/mol.106.031351
Cloning, Heterologous Expression, and in Situ Characterization of the First High Affinity Nucleobase Transporter from a Protozoan 10.1074/jbc.m301252200
Modulation of the Host Cell Proteome by the Intracellular Apicomplexan Parasite Toxoplasma gondii 10.1128/iai.01115-07
Genetic characterization of glucose transporter function in Leishmania mexicana 10.1073/pnas.0630165100
A defined medium for Leishmania culture allows definition of essential amino acids 10.1016/j.exppara.2018.01.009
Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability 10.1038/s41467-017-02585-y
The role of membrane transporters in Leishmania virulence 10.1042/etls20170119
The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei 10.1371/journal.pntd.0005626
Pulse of inflammatory proteins in the pregnant uterus of European polecats (Mustela putorius) leading to the time of implantation 10.1098/rsos.161085
Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB/c mice against infection with virulent L. major 10.1017/s0031182009990679
Quantitative proteomic profiling of bovine follicular fluid during follicle development† 10.1093/biolre/iox148
Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection 10.1038/s41598-017-03100-5
Proteomics in Veterinary Medicine 10.1177/0300985813502819
Rapid changes in Atlantic grey seal milk from birth to weaning – immune factors and indicators of metabolic strain 10.1038/s41598-017-16187-7
181 Nox compartmentalization and protein oxidation in vascular smooth muscle cells – implications in vascular dysfunction in hypertension 10.1136/heartjnl-2017-311726.179
Serum proteome profiling in canine idiopathic dilated cardiomyopathy using TMT-based quantitative proteomics approach 10.1016/j.jprot.2018.03.007
Mix-and-Match Proteomics: Using Advanced Iodoacetyl Tandem Mass Tag Multiplexing To Investigate Cysteine Oxidation Changes with Respect to Protein Expression 10.1021/acs.analchem.8b02517
Comparative bioinformatic and proteomic approaches to evaluate the outer membrane proteome of the fish pathogen Yersinia ruckeri 10.1016/j.jprot.2019.02.014
PROTEOMIC ANALYSIS OF GLYCOSOMES FROM Trypanosoma cruzi EPIMASTIGOTES. 10.1016/j.molbiopara.2019.02.008
Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death. 10.15252/embj.2018100024
Low sulfated heparins target multiple proteins for central nervous system repair. 10.1002/glia.23562
Blood serum acute phase proteins and iron dynamics during acute phase response of Salmonella enterica serotype Dublin experimentally infected buffalo calves. 10.1016/j.vetimm.2018.07.014
A proteomic analysis unravels novel CORVET and HOPS proteins involved in Toxoplasma gondii secretory organelles biogenesis. 10.1111/cmi.12870
Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in Hypertension. 10.1161/HYPERTENSIONAHA.118.10824
Reference 1D and 2D electrophoresis maps for potential disease related proteins in milk whey from lactating buffaloes and blood serum from buffalo calves (Water buffalo, Bubalus bubalis). 10.1016/j.rvsc.2018.04.010
Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana. 10.1371/journal.ppat.1006953
Identification of novel biomarkers for treatment monitoring in canine leishmaniosis by high-resolution quantitative proteomic analysis. 10.1016/j.vetimm.2017.08.004
Rapid changes in Atlantic grey seal milk from birth to desertion 10.1101/170514
Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana. 10.1371/journal.pntd.0005649
The effect of microbial challenge on the intestinal proteome of broiler chickens. 10.1186/s12953-017-0118-0
Correction: Gentamicin-Attenuated Leishmania infantum Vaccine: Protection of Dogs against Canine Visceral Leishmaniosis in Endemic Area of Southeast of Iran. 10.1371/journal.pntd.0003787
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. 10.1093/jac/dkt442
The serum proteome of Atlantic salmon, Salmo salar, during pancreas disease (PD) following infection with salmonid alphavirus subtype 3 (SAV3). 10.1016/j.jprot.2013.10.016
Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds. 10.1074/jbc.M111.233858
Essential roles for deubiquitination in Leishmania life cycle progression 10.1101/2020.03.05.978528
Mapping the influence of the gut microbiota on small molecules in the brain through mass spectrometry imaging 10.1101/2020.03.13.987164
The potential of live attenuated vaccines against Cutaneous Leishmaniasis. 10.1016/j.exppara.2020.107849
Multi-Layer Controls of Cas9 Activity Coupled With ATP Synthase Over-Expression for Efficient Genome Editing in Streptomyces. 10.3389/fbioe.2019.00304
Pharmacometabolomics of Meglumine Antimoniate in Patients With Cutaneous Leishmaniasis. 10.3389/fphar.2019.00657
Mapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC-MS. 10.1042/BSR20181601
Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection 10.3390/v12050524
Essential roles for deubiquitination in Leishmania life cycle progression 10.1371/journal.ppat.1008455
aBravo Is a Novel Aedes aegypti Antiviral Protein That Interacts with, but Acts Independently of, the Exogenous siRNA Pathway Effector Dicer 2 10.3390/v12070748
Effects of Low ω6:ω3 Ratio in Sow Diet and Seaweed Supplement in Piglet Diet on Performance, Colostrum and Milk Fatty Acid Profiles, and Oxidative Status 10.3390/ani10112049
Karl Burgess
Burgess Karl
ORCID: 0000-0002-0881-715X
Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines. 10.3389/fbioe.2015.00026
Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism. 10.1016/j.ijpddr.2013.11.002
Strategies to dissect parasite proteomes. 10.1017/S0031182011002368
Recent advances in liquid and gas chromatography methodology for extending coverage of the metabolome 10.1016/j.copbio.2016.09.006
A novel targeted/untargeted GC-Orbitrap metabolomics methodology applied to Candida albicans and Staphylococcus aureus biofilms 10.1007/s11306-016-1134-2
MetaboCraft: building a Minecraft plugin for metabolomics 10.1093/bioinformatics/bty102
Minimally-destructive atmospheric ionisation mass spectrometry authenticates authorship of historical manuscripts 10.1038/s41598-018-28810-2
Plasma Itaconate elevation following successful cDMARD treatment in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation 10.1101/19001594
Changing environments and genetic variation: natural variation in inbreeding does not compromise short-term physiological responses 10.1098/rspb.2019.2109
Functional colour genes and signals of selection in colour‐polymorphic salamanders 10.1111/mec.15411
Decomposing metabolite set activity levels with PALS 10.1101/2020.06.07.138974
Schistosoma haematobium infection is associated with alterations in energy and purine-related metabolism in preschool-aged children 10.1371/journal.pntd.0008866
Ranking Metabolite Sets by Their Activity Levels 10.3390/metabo11020103