The Intestinal Epithelium: Central Coordinator of Mucosal Immunity
Allaire, J.M.
Crowley, S.M.
Law, H.T.
Chang, S.-Y.
Ko, H.-J.
Vallance, B.A.
Trends in immunology, 2018-4-30
Hyun-Jeong Ko
Ko Hyun-Jeong
ORCID: 0000-0002-3844-928X
Email: hjko@kangwon.ac.kr
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Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection
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Enteropathogenic Escherichia coli infection induces expression of the early growth response factor by activating mitogen-activated protein kinase cascades in epithelial cells
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Locus of enterocyte effacement from Citrobacter rodentium: Sequence analysis and evidence for horizontal transfer among attaching and effacing pathogens
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Mast cell-independent impairment of host defense and muscle contraction in T. spiralis-infected W/Wv mice
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Critical role for signal transducer and activator of transcription factor 6 in mediating intestinal muscle hypercontractility and worm expulsion in Trichinella spiralis-infected mice
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Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections
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Exploitation of host cells by enteropathogenic Escherichia coli
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The effect of nematode infection upon intestinal smooth muscle function
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Cutting Edge: Intestinal Mucus Limits the Clonal Deletion of Developing T Cells Specific for an Oral Antigen
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Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes
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The Muc2 mucin coats murine paneth cell granules and facilitates their content release and dispersion
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The helical shape of Campylobacter jejuni promotes in vivo pathogenesis by aiding transit through intestinal mucus and colonization of crypts
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Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection
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The goblet cell-derived mediator RELM-β drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis
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Frontline defenders: Goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease
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Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome
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Insights into Campylobacter jejuni colonization of the mammalian intestinal tract using a novel mouse model of infection
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Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation
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Giardia spp. promote the production of antimicrobial peptides and attenuate disease severity induced by attaching and effacing enteropathogens via the induction of the NLRP3 inflammasome
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Vasoactive intestinal peptide prevents PKCε-induced intestinal epithelial barrier disruption during EPEC infection
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Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens
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Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium
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Escherichia coli pathobionts associated with inflammatory bowel disease
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Pediatric eosinophilic esophagitis is associated with increased lamina propria immunoglobulin g4-positive plasma cells
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Bacterial AB 5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
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The Intestinal Epithelium: Central Coordinator of Mucosal Immunity
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Interleukin-1 (IL-1) signaling in intestinal stromal cells controls KC/ CXCL1 secretion, which correlates with recruitment of IL-22- secreting neutrophils at early stages of Citrobacter rodentium infection
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Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis
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Isolation and characterization of potentially probiotic bacterial strains from mice: proof of concept for personalized probiotics
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Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria
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Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development
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Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accelerates diabetes in NOD mice
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IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production
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Genetic ablation of cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition
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A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function
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Mouse models for Campylobacter jejuni colonization and infection
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Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice
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Tricellular tight junction protein tricellulin is targeted by the enteropathogenic Escherichia coli effector EspG1, leading to epithelial barrier disruption
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Poor Correlation of Oral Swabs with Esophageal Eosinophil Counts
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The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria
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Dynamic interactions of a conserved enterotoxigenic Escherichia coli adhesin with intestinal mucins govern epithelium engagement and toxin delivery
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Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation
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Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen
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Skin exposure to narrow band ultraviolet (Uvb) light modulates the human intestinal microbiome
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Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease
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Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis
10.1152/ajpgi.00006.2015
The serine protease autotransporter Pic modulates Citrobacter rodentium pathogenesis and its innate recognition by the host
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IL-22 preserves gut epithelial integrity and promotes disease remission during chronic Salmonella infection
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Salmonella and the inflammasome: Battle for intracellular dominance
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First-reported pediatric cases of American ginseng anaphylaxis and allergy
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SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis
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Investigation of host and pathogen contributions to infectious colitis using the citrobacter rodentium mouse model of infection
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TLR9 limits enteric antimicrobial responses and promotes microbiota-based colonisation resistance during Citrobacter rodentium infection
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EspF is crucial for citrobacter rodentium-induced tight junction disruption and lethality in immunocompromised animals
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Humoral immunity in the gut selectively targets phenotypically virulent attaching-and-effacing bacteria for intraluminal elimination
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Noncanonical inflammasomes: Antimicrobial defense that does not play by the rules
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NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis
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Metalloprotease NleC Suppresses Host NF-κB/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction
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mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium
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A novel mouse model of enteric vibrio parahaemolyticus infection reveals that the type iii secretion system 2 effector vopc plays a key role in tissue invasion and gastroenteritis
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Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis
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Microbiota inhibit epithelial pathogen adherence by epigenetically regulating C-type lectin expression
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Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells
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Enteroids Derived From Inflammatory Bowel Disease Patients Display Dysregulated Endoplasmic Reticulum Stress Pathways, Leading to Differential Inflammatory Responses and Dendritic Cell Maturation.
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Intestinal-epithelial LSD1 controls cytoskeletal-mediated cell identity including goblet cell effector responses required for gut inflammatory and infectious diseases
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Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease.
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Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium
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Report on the Canadian Association of Gastroenterology Visiting Research Professorship and Visiting Clinical Professorship.
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Association of host genome with intestinal microbial composition in a large healthy cohort.
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Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis
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Interleukin-37 Regulates Innate Immune Signaling in Human and Mouse Colonic Organoids
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Microbial Respiration in the Colon: Using H2 O2 to Catch Your Breath
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Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts
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Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis
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Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes
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Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn’s disease subjects
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Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease
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The Citrobacter rodentium mouse model: studying pathogen and host contributions to infectious colitis.
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Toll-Like Receptors are critical in controlling colonic inflammation and cancer.
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AN INULIN-TYPE FRUCTAN ENRICHED EXCLUSIVE ENTERAL NUTRITION FORMULA SUPPRESSES COLITIS THROUGH GUT MICROBIOME MODULATION AND PROMOTING EXPANSION OF ANTI-INFLAMMATORY T CELL SUBSETS
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Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection
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Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis
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Serum Zonulin Measured by Commercial Kit Fails to Correlate With Physiologic Measures of Altered Gut Permeability in First Degree Relatives of Crohn's Disease Patients
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Harnessing Big Data to Optimize an Algorithm for Rapid Diagnosis of Pulmonary Tuberculosis in a Real-World Setting
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Direct Clinical Evidence Recommending the Use of Proteinase K or Dithiothreitol to Pretreat Sputum for Detection of SARS-CoV-2
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Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids
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What’s for dinner? How Citrobacter rodentium’s metabolism helps it thrive in the competitive gut
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