Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents
Jehad Almaliti
Bailey Miller
Halina Pietraszkiewicz
Evgenia Glukhov
C. Benjamin Naman
Toni Kline
Jeffrey Hanson
Xiaofan Li
Sihong Zhou
Frederick A. Valeriote
William H. Gerwick
C. Benjamin Naman
Naman C. Benjamin
ORCID: 0000-0002-4361-506X
Computer-Assisted Structure Elucidation of Black Chokeberry (Aronia melanocarpa) Fruit Juice Isolates with a New Fused Pentacyclic Flavonoid Skeleton.
10.1021/acs.orglett.5b01284
Northalrugosidine is a bisbenzyltetrahydroisoquinoline alkaloid from Thalictrum alpinum with in vivo antileishmanial activity.
10.1021/np501028u
Pyrrole alkaloids with potential cancer chemopreventive activity isolated from a goji berry-contaminated commercial sample of African mango.
10.1021/jf500802x
Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.
10.1021/acs.jnatprod.5b01131
A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.
10.1021/acsinfecdis.5b00081
Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium.
10.1021/acs.jnatprod.6b00907
Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata.
10.3390/md15040121
Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products.
10.1007/s13205-017-0610-3
Preparative Separation and Purification of Trichothecene Mycotoxins from the Marine Fungus Fusarium sp. LS68 by High-Speed Countercurrent Chromatography in Stepwise Elution Mode
10.3390/md16020073
5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro.
10.3390/molecules22101651
Bioassay-Guided Isolation of Antioxidant and Cytoprotective Constituents from a Maqui Berry (Aristotelia chilensis) Dietary Supplement Ingredient As Markers for Qualitative and Quantitative Analysis.
10.1021/acs.jafc.7b03261
5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34.
10.3390/md15080260
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species.
10.1021/acs.jnatprod.7b00367
MetaRiPPquest: A Peptidogenomics Approach for the Discovery of Ribosomally Synthesized and Post-translationally Modified Peptides
10.1101/227504
Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β.
10.1021/acschemneuro.7b00527
Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States.
10.1016/j.jtcme.2018.01.006
Phytodrugs and Immunomodulators for the Therapy of Leishmaniasis
10.1016/b978-0-08-102081-4.00009-5
Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation
10.1016/b978-0-12-804765-1.00005-9
Pharmaceuticals, Plant Drugs
10.1016/b978-0-12-394807-6.00163-5
DNA Binding and Molecular Dynamic Studies of Polycyclic Tetramate Macrolactams (PTM) with Potential Anticancer Activity Isolated from a Sponge-Associated Streptomyces zhaozhouensis subsp. mycale subsp. nov.
10.1007/s10126-018-9866-9
Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice.
10.3389/fncel.2018.00396
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents.
10.1016/j.ejmech.2018.10.024
A new lateral root growth inhibitor from the sponge-derived fungus Aspergillus sp. LS45
10.1016/j.bmcl.2019.04.051
9-Methylfascaplysin Is a More Potent Aβ Aggregation Inhibitor than the Marine-Derived Alkaloid, Fascaplysin, and Produces Nanomolar Neuroprotective Effects in SH-SY5Y Cells.
10.3390/md17020121
25C-NBOMe, a Novel Designer Psychedelic, Induces Neurotoxicity 50 Times More Potent Than Methamphetamine In Vitro.
10.1007/s12640-019-0012-x
Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca2+-ATPase.
10.1016/j.fitote.2019.04.005
A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors.
10.3390/md17090493
Isolation and Analysis of Antioxidant Phytochemicals from Black Chokeberry, Maqui, and Goji Berry Dietary Supplements
10.1021/bk-2018-1286.ch001
Investigation of Vietnamese plants for potential anticancer agents
10.1007/s11101-014-9335-7
Phthalideisoquinoline Hemiacetal Alkaloids from Corydalis decumbens That Inhibit Spontaneous Calcium Oscillations, including Alkyl Derivatives of (+)-Egenine That Are Strikingly Levorotatory
10.1021/acs.jnatprod.9b00247
Prospects of multitarget drug designing strategies by linking molecular docking and molecular dynamics to explore the protein–ligand recognition process
10.1002/ddr.21673
Three New Diketopiperazines from the Previously Uncultivable Marine Bacterium Gallaecimonas mangrovi HK-28 Cultivated by iChip.
10.1002/cbdv.202000221
MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities.
10.1016/j.cels.2019.09.004
New Dihydroisocoumarin Root Growth Inhibitors From the Sponge-Derived Fungus Aspergillus sp. NBUF87.
10.3389/fmicb.2019.02846
Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties.
10.1021/acschembio.9b00992
The Chemistry, Biochemistry and Pharmacology of Marine Natural Products from Leptolyngbya, a Chemically Endowed Genus of Cyanobacteria
10.3390/md18100508
Applying a Chemogeographic Strategy for Natural Product Discovery from the Marine Cyanobacterium Moorena bouillonii
10.3390/md18100515
Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy
10.3390/ijms22052408
Metabolomic Characterization of a cf. Neolyngbya Cyanobacterium from the South China Sea Reveals Wenchangamide A, a Lipopeptide with In Vitro Apoptotic Potential in Colon Cancer Cells
10.3390/md19070397
Bailey Miller
Miller Bailey
ORCID: 0000-0003-3204-3235
Synergistic anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and absolute stereochemistry of 7,8-dideoxygriseorhodin C
10.1038/s41429-019-0275-8
Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae
10.3390/md18120656
The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L
10.1021/np400727r
Synthesis of Gallinamide A Analogues as Potent Falcipain Inhibitors and Antimalarials
10.1021/jm501439w
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents
10.1016/j.ejmech.2018.10.024
jehad almaliti
almaliti jehad
ORCID: 0000-0002-3562-0846
Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel
10.1016/j.chembiol.2016.04.008
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria
10.1021/acs.jnatprod.5b00301
Natural products inspired synthesis of neuroprotective agents against H2O2-induced cell death
10.1016/j.bmcl.2013.01.013
Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens
10.1021/acs.jnatprod.7b00034
Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species
10.1021/acs.jnatprod.7b00367
20S proteasome as a drug target in Trichomonas vaginalis
10.1128/AAC.00448-19
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages
10.1016/j.foodchem.2019.125290
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
10.1021/acs.jmedchem.7b00671
The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni
10.1021/acsinfecdis.9b00237
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents
10.1016/j.ejmech.2018.10.024
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain
10.1021/acs.jmedchem.9b00294
Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue
10.1021/acs.jmedchem.6b01271
Evgenia Glukhov
Glukhov Evgenia
ORCID: 0000-0001-6513-9909
Bioprospecting Portuguese Atlantic coast cyanobacteria for bioactive secondary metabolites reveals untapped chemodiversity
10.1016/j.algal.2015.03.016
MetaRiPPquest: A Peptidogenomics Approach for the Discovery of Ribosomally Synthesized and Post-translationally Modified Peptides
10.1101/227504
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents
10.1016/j.ejmech.2018.10.024