Paperbase

Anja Paatero

Paatero Anja / Anja Onerva Paatero

ORCID: 0000-0003-2193-2483

https://researchportal.helsinki.fi/en/persons/7e573453-d12e-4932-a35c-bce568ae71cd

Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel 10.1016/j.chembiol.2016.04.008

Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding 10.1021/acs.biochem.5b00971

LRRTM3 is Dispensable for Amyloid-beta Production in Mice 10.3233/JAD-2012-120193

Bacteriophage Mu integration in yeast and mammalian genomes 10.1093/nar/gkn801

Nonspecific Nucleoside Triphosphatase P4 of Double-Stranded RNA Bacteriophage f6 Is Required for Single-Stranded RNA Packaging and Transcription 10.1128/jvi.76.20.10122-10127.2002

Mycolactone subverts immunity by selectively blocking the Sec61 translocon 10.1084/jem.20160662

A symmetry mismatch at the site of RNA packaging in the polymerase complex of dsRNA bacteriophage phi6. 10.1006/jmbi.1999.3260

NTP binding induces conformational changes in the double-stranded RNA bacteriophage ø6 subviral particles. 10.1006/viro.1994.1632

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation 10.26434/chemrxiv.7581764

Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature. 10.1074/mcp.ra118.000824

Ipomoeassin F Binds Sec61 alpha to Inhibit Protein Translocation 10.1021/jacs.8b13506

Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins 10.1021/acschembio.0c00325

Ville Paavilainen

Paavilainen Ville

ORCID: 0000-0002-3160-7767

http://www.biocenter.helsinki.fi/bi/paavilainen/index.html

Prolonged and tunable residence time using reversible covalent kinase inhibitors 10.1038/nchembio.1817

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate 10.7554/eLife.01483

Electrophilic fragment-based design of reversible covalent kinase inhibitors 10.1021/ja401221b

Proteostasis modulators with discriminating taste 10.1016/j.chembiol.2013.02.002

GMF Is a Cofilin Homolog that Binds Arp2/3 Complex to Stimulate Filament Debranching and Inhibit Actin Nucleation 10.1016/j.cub.2010.03.026

Structure of the actin-depolymerizing factor homology domain in complex with actin 10.1083/jcb.200803100

Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism. 10.1083/jcb.200609176

Structural basis and evolutionary origin of actin filament capping by twinfilin 10.1073/pnas.0608725104

NMR assignment of the C-terminal ADF-H domain of an actin monomer binding protein, twinfilin. 10.1007/s10858-006-9052-7

(1)H, (13)C and (15)N resonance assignments of coactosin, a cytoskeletal regulatory protein. 10.1007/s10858-005-1068-x

Solution structure of coactosin reveals structural homology to ADF/cofilin family proteins 10.1016/j.febslet.2004.08.068

Biological role and structural mechanism of twinfilin-capping protein interaction 10.1038/sj.emboj.7600310

Regulation of cytoskeletal dynamics by actin-monomer-binding proteins 10.1016/j.tcb.2004.05.002

The two ADF-H domains of twinfilin play functionally distinct roles in interactions with actin monomers 10.1091/mbc.E02-03-0157

Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin 10.1074/jbc.M208225200

Identification of yeast cofilin residues specific for actin monomer and PIP2 binding. 10.1021/bi0117697

Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel 10.1016/j.chembiol.2016.04.008

Mycolactone subverts immunity by selectively blocking the Sec61 translocon 10.1084/jem.20160662

Functional reconstitution of human equilibrative nucleoside transporter-1 into styrene maleic acid co-polymer lipid particles 10.1016/j.bbamem.2017.02.017

Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature 10.1074/mcp.RA118.000824

Rapamycin-inspired macrocycles with new target specificity 10.1038/s41557-018-0187-4

ASD-associated de novo mutations in five actin regulators show both shared and distinct defects in dendritic spines and inhibitory synapses in cultured hippocampal neurons 10.3389/fncel.2018.00217

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation. 10.1021/jacs.8b13506

Wherever I may roam: organellar protein targeting and evolvability. 10.1016/j.gde.2019.07.012

Carbonic anhydrase VII regulates dendritic spine morphology and density via actin filament bundling 10.1101/736868

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation 10.26434/chemrxiv.7581764

Current Progress on Equilibrative Nucleoside Transporter Function and Inhibitor Design 10.1177/2472555219870123

Natural products as modulators of eukaryotic protein secretion 10.1039/C9NP00066F

Kendomycin Cytotoxicity against Bacterial, Fungal, and Mammalian Cells Is Due to Cation Chelation 10.1021/acs.jnatprod.9b00826

A novel phylogenetic analysis and machine learning predict pathogenicity of human mtDNA variants 10.1101/2020.01.10.902239

Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A 10.1016/j.bcp.2020.114317

jehad almaliti

almaliti jehad

ORCID: 0000-0002-3562-0846

Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel 10.1016/j.chembiol.2016.04.008

Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria 10.1021/acs.jnatprod.5b00301

Natural products inspired synthesis of neuroprotective agents against H2O2-induced cell death 10.1016/j.bmcl.2013.01.013

Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034

Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367

20S proteasome as a drug target in Trichomonas vaginalis 10.1128/AAC.00448-19

Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages 10.1016/j.foodchem.2019.125290

Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity 10.1021/acs.jmedchem.7b00671

The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni 10.1021/acsinfecdis.9b00237

Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents 10.1016/j.ejmech.2018.10.024

Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain 10.1021/acs.jmedchem.9b00294

Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue 10.1021/acs.jmedchem.6b01271