Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
Peter Cimermancic Marnix H. Medema Jan Claesen Kenji Kurita Laura C. Wieland Brown Konstantinos Mavrommatis Amrita Pati Paul A. Godfrey Michael Koehrsen Jon Clardy Bruce W. Birren Eriko Takano Andrej Sali Roger G. Linington Michael A. Fischbach
Cell, 2014-7
https://doi.org/10.1016/j.cell.2014.06.034
Michael Fischbach
Fischbach Michael
ORCID: 0000-0003-3079-8247
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Takano Eriko
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Marnix H. Medema
Medema Marnix H.
ORCID: 0000-0002-2191-2821
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A Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology. 10.1021/jacs.7b13292
Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium. 10.3389/fmicb.2018.01158
Involvement of Burkholderiaceae and sulfurous volatiles in disease-suppressive soils. 10.1038/s41396-018-0186-x
Genomic Identification and Analysis of Specialized Metabolite Biosynthetic Gene Clusters in Plants Using PlantiSMASH. 10.1007/978-1-4939-7874-8_15
A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene cluster (MIBiG) repository: prospects for research-based educational experiences 10.1186/s40793-018-0318-y
The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters 10.1093/nar/gky1060
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1101/463620
Mining bacterial genomes to reveal secret synergy 10.1074/jbc.H118.006669
Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters 10.1038/s42003-019-0333-6
Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae 10.1111/tpj.14292
A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters 10.1186/s13104-019-4222-3
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline 10.1093/nar/gkz310
MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools 10.1101/654459
BiosyntheticSPAdes: Reconstructing Biosynthetic Gene Clusters From Assembly Graphs 10.1101/gr.243477.118
Genome Mining Approaches to Bacterial Natural Product Discovery 10.1016/b978-0-12-409547-2.14627-x
Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines 10.1039/C9NP00021F
PlantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters 10.1101/083535
MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools 10.3390/metabo9070144
Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L. 10.3389/fpls.2019.00846
Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome 10.1126/science.aaw9285
MIBiG 2.0: a repository for biosynthetic gene clusters of known function 10.1093/nar/gkz882
A metabolic pathway for bile acid dehydroxylation by the gut microbiome 10.1101/758557
Coevolution-based prediction of protein-protein interactions in polyketide biosynthetic assembly lines 10.1101/669291
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery 10.1021/acscentsci.9b00806
Cultivation and functional characterization of 79 planctomycetes uncovers their unique biology 10.1038/s41564-019-0588-1
Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia 10.1101/856955
Drivers of metabolic diversification: how dynamic genomic neighbourhoods generate new biosynthetic pathways in the Brassicaceae 10.1111/nph.16338
Microbial and volatile profiling of soils suppressive to Fusarium culmorum of wheat 10.1098/rspb.2019.2527
Computational genomic discovery of diverse gene clusters harboring Fe-S flavoenzymes in anaerobic gut microbiota 10.1101/2020.03.06.976126
RRE-Finder: A Genome-Mining Tool for Class-Independent RiPP Discovery 10.1101/2020.03.14.992123
Linking genomics and metabolomics to chart specialized metabolic diversity 10.1039/D0CS00162G
Computational genomic discovery of diverse gene clusters harbouring Fe-S flavoenzymes in anaerobic gut microbiota 10.1099/mgen.0.000373
ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining 10.1093/nar/gkaa374
Integration of machine learning and pan-genomics expands the biosynthetic landscape of RiPP natural products 10.1101/2020.05.19.104752
Ecology and genomics of Actinobacteria: new concepts for natural product discovery 10.1038/s41579-020-0379-y
The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms 10.1038/s42003-020-0993-2
BiG-SLiCE: A Highly Scalable Tool Maps the Diversity of 1.2 Million Biosynthetic Gene Clusters 10.1101/2020.08.17.240838
Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia 10.1074/jbc.RA120.013528
Microbial natural product databases: moving forward in the multi-omics era 10.1039/D0NP00053A
Author Correction: The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms 10.1038/s42003-020-01228-1
RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery 10.1128/mSystems.00267-20
Author Correction: The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms 10.1038/s42003-020-01271-y
BiG-FAM: the biosynthetic gene cluster families database 10.1093/nar/gkaa812
Coevolution-based prediction of protein–protein interactions in polyketide biosynthetic assembly lines 10.1093/bioinformatics/btaa595
The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes 10.1093/nar/gkaa978
Pan-genome analysis and ancestral state reconstruction of class halobacteria: probability of a new super-order 10.1038/s41598-020-77723-6
BiG-MAP: an automated pipeline to profile metabolic gene cluster abundance and expression in microbiomes 10.1101/2020.12.14.422671
Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides 10.1371/journal.pbio.3001026
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters 10.1093/gigascience/giaa154
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases 10.1039/D0NP00090F
Do size and shape matter? Exploring the interactions and the metabolome of the soil isolate Hylemonella gracilis 10.1101/2021.02.11.430889
A systematic analysis of metabolic pathways in the human gut microbiota 10.1101/2021.02.25.432841
Omics-based strategies to discover novel classes of RiPP natural products 10.1016/j.copbio.2020.12.008
Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria 10.1038/s41467-021-21163-x
The Surfactin-Like Lipopeptides From Bacillus spp.: Natural Biodiversity and Synthetic Biology for a Broader Application Range 10.3389/fbioe.2021.623701
Mining metagenomes for natural product biosynthetic gene clusters: unlocking new potential with ultrafast techniques 10.1101/2021.01.20.427441
Extracting the GEMs: Genotype, Environment, and Microbiome Interactions Shaping Host Phenotypes 10.3389/fmicb.2020.574053
A mammalian commensal of the oropharyngeal cavity produces antibiotic and antiviral valinomycin in vivo 10.21203/rs.3.rs-126949/v1
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters 10.1016/j.chembiol.2020.11.009
cblaster: a remote search tool for rapid identification and visualisation of homologous gene clusters 10.1101/2020.11.08.370601
antiSMASH 6.0: improving cluster detection and comparison capabilities 10.1093/nar/gkab335
The gutSMASH web server: automated identification of primary metabolic gene clusters from the gut microbiota 10.1093/nar/gkab353
Mining genomes to illuminate the specialized chemistry of life 10.1038/s41576-021-00363-7
Dominant drivers of the human plasma metabolome 10.21203/rs.3.rs-688716/v1
A global survey of specialized metabolic diversity encoded in bacterial genomes 10.1101/2021.08.11.455920
cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters 10.1093/bioadv/vbab016
Konstantinos Mavrommatis
Mavrommatis Konstantinos
ORCID: 0000-0003-4549-385X
Multi-omics of permafrost, active layer and thermokarst bog soil microbiomes 10.1038/nature14238
Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study 10.1371/journal.pone.0208144
Erratum: Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma (Blood (2018) 132:6 (587-597) DOI : 10.1182/blood-2018-03-840132) 10.1182/blood-2018-08-870022
Complete genome sequence of Desulfurococcus fermentans, a hyperthermophilic cellulolytic crenarchaeon isolated from a freshwater hot spring in Kamchatka, Russia 10.1128/JB.01314-12
Permanent draft genome sequence of Nocardia sp. BMG111209, an actinobacterium isolated from nodules of Casuarina glauca 10.1128/genomeA.00770-16
Genome sequence of Burkholderia mimosarum strain LMG 23256T, a mimosa pigra microsymbiont from Anso, Taiwan 10.4056/sigs.4848627
Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance 10.1158/1541-7786.MCR-17-0554
Genome sequence of Streptomyces viridosporus strain T7A ATCC 39115, a lignin-degrading actinomycete 10.1128/genomeA.00416-13
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters 10.1016/j.cell.2014.06.034
Complete genome sequence of Jonesia denitrificans type strain (Prevot 55134 T) 10.4056/sigs.41646
Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma 10.1182/blood-2018-03-840132
Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy 10.1371/journal.pone.0174518
Complete genome of Enterobacteriaceae bacterium strain FGI 57, a strain associated with leaf-cutter ant fungus gardens 10.1128/genomeA.00238-12
Whole genome sequencing of Thermus oshimai JL-2 and Thermus thermophilus JL-18, incomplete denitrifiers from the United States Great Basin 10.1128/genomeA.00106-12
Prevalence of propionibacterium acnes in intervertebral discs of patients undergoing lumbar microdiscectomy: A prospective cross-sectional study 10.1371/journal.pone.0161676
Accelerating gene context analysis using bitmaps 10.1145/2484838.2484856
A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis 10.1038/s41375-018-0196-8
Complete genome sequence of Slackia heliotrinireducens type strain (RHS T) 10.4056/sigs.37633
An experimental metagenome data management and analysis system 10.1093/bioinformatics/btl217
Permanent draft genome sequences of the symbiotic nitrogen fixing Ensifer meliloti strains BO21CC and AK58 10.4056/sigs.3797438
Genome sequence of the Medicago-nodulating Ensifer meliloti commercial inoculant strain RRI128 10.4056/sigs.4929626
Genome sequence of the lupin-nodulating Bradyrhizobium sp. strain WSM1417 10.4056/sigs.4518260
Draft genome sequence of Frankia sp. strain DC12, an atypical, noninfective, ineffective isolate from Datisca cannabina 10.1128/genomeA.00889-15
Complete genome sequence of Dyadobacter fermentans type strain (NS114 T) 10.4056/sigs.19262
Draft genome sequence of Frankia sp. strain CN3, an atypical, noninfective (Nod-) ineffective (Fix-) isolate from Coriaria nepalensis 10.1128/genomeA.00085-13
Microbial diversity for biotechnology 10.1155/2014/845972
Draft genome sequence of Frankia sp. strain BCU110501, a nitrogen-fixing actinobacterium isolated from nodules of Discaria trinevis 10.1128/genomeA.00503-13
The M5nr: A novel non-redundant database containing protein sequences and annotations from multiple sources and associated tools 10.1186/1471-2105-13-141
Genome sequence of Ensifer arboris strain LMG 14919T; a microsymbiont of the legume Prosopis chilensis growing in Kosti, Sudan 10.4056/sigs.4828625
Genome sequence of Ensifer medicae strain WSM1115; an acid-tolerant Medicago-nodulating microsymbiont from Samothraki, Greece 10.4056/sigs.4938652
Complete genome sequence of Halomicrobium mukohataei type strain (arg-2 T ) 10.4056/sigs.42644
Complete genome sequence of leptotrichia buccalis type strain (C-1013-b T) 10.4056/sigs.1854
Permanent improved high-quality draft genome sequence of Nocardia casuarinae strain BMG51109, an endophyte of actinorhizal root nodules of Casuarina glauca 10.1128/genomeA.00799-16
Draft genome sequence of Frankia sp. strain QA3, a nitrogen-fixing actinobacterium isolated from the root nodule of Alnus nitida 10.1128/genomeA.00103-13
Complete genome sequence of Cryptobacterium curtum type strain (12-3 T ) 10.4056/sigs.12260
Draft genome sequence of Frankia sp. strain BMG5.12, a nitrogen-fixing actinobacterium isolated from Tunisian soils 10.1128/genomeA.00468-13
Genome sequence of Rhizobium leguminosarum bv trifolii strain WSM1689, the microsymbiont of the one flowered clover Trifolium uniflorum 10.4056/sigs.4988693
Complete genome sequence of Enterobacter sp. IIT-BT 08: A potential microbial strain for high rate hydrogen production 10.4056/sigs.4348035
Complete genome sequence of capnocytophaga ochra-cea type strain (VPI 2845 T) 10.4056/sigs.15195
Complete genome of Serratia sp. strain FGI 94, a strain associated with leaf-cutter ant fungus gardens 10.1128/genomeA.00239-12
Thermus oshimai JL-2 and T. thermophilus JL-18 genome analysis illuminates pathways for carbon, nitrogen, and sulfur cycling 10.4056/sigs.3667269
Complete genome sequence of Pirellula staleyi type strain (ATCC 27377 T) 10.4056/sigs.51657
Microbial species delineation using whole genome sequences 10.1093/nar/gkv657
Genome sequence of the clover-nodulating Rhizobium leguminosarum bv. trifolii strain TA1 10.4056/sigs.4488254
Complete genome sequence of the lignin-degrading bacterium Klebsiella sp. strain BRL6-2 10.1186/1944-3277-9-19
Complete genome sequence of cellulomonas flavigena type strain (134 T) 10.4056/sigs.1012662
Non-contiguous finished genome sequence of plant-growth promoting Serratia proteamaculan S4 10.4056/sigs.4027757
Genome sequence of the flexirubin-pigmented soil bacterium Niabella soli type strain (JS13-8T) 10.4056/sigs.3117229
The complete multipartite genome sequence of Cupriavidus necator JMP134, a versatile pollutant degrader 10.1371/journal.pone.0009729
Complete genome sequence of Arcobacter nitrofigilis type strain (CI T) 10.4056/sigs.912121
Complete genome sequence of the facultatively anaerobic, appendaged bacterium Muricauda ruestringensis type strain (B1T) 10.4056/sigs.2786069
Complete genome sequence of Thioalkalivibrio sp. K90mix 10.4056/sigs.2315092
IMG 4 version of the integrated microbial genomes comparative analysis system 10.1093/nar/gkt963
Genome sequence of the Antarctic rhodopsins-containing flavobacterium Gillisia limnaea type strain (R-8282T) 10.4056/sigs.3216895
Complete genome sequence of Atopobium parvulum type strain (IPP 1246 T) 10.4056/sigs.29547
Complete genome sequence of bacteroides salanitronis type strain (BL78 T) 10.4056/sigs.1704212
Genome sequence of the homoacetogenic bacterium Holophaga foetida type strain (TMBS4T) 10.4056/sigs.2746047
Complete genome sequence of Deinococcus maricopensis type strain (LB-34 T) 10.4056/sigs.1633949
Complete genome sequence of Syntrophothermus lipocalidus type strain (TGB-C1 T) 10.4056/sigs.1233249
Complete genome sequence of Spirosoma linguale type strain (1 T) 10.4056/sigs.741334
Complete genome sequence of the aerobic, heterotroph Marinithermus hydrothermalis type strain (T1 T) from a deep-sea hydrothermal vent chimney 10.4056/sigs.2435521
Complete genome sequence of Planctomyces brasiliensis type strain (DSM 5305T), phylogenomic analysis and reclassification of Planctomycetes including the descriptions of Gimesia gen. nov., Planctopirus gen. nov. and Rubinisphaera gen. nov. and emended descriptions of the order Planctomycetales and the family Planctomycetaceae 10.1186/1944-3277-9-10
Complete genome sequence of Mycobacterium sp. strain (Spyr1) and reclassification to Mycobacterium gilvum spyr1 10.4056/sigs.2265047
Complete genome sequence of Thermobispora bispora type strain (R51 T) 10.4056/sigs.962171
Complete genome sequence of Tsukamurella paurometabola type strain (no. 33 T) 10.4056/sigs.1894556
Genome sequence of the acid-tolerant Burkholderia sp. strain WSM2232 from Karijini National Park, Australia 10.4056/sigs.5018795
Complete genome sequence of Hydrogenobacter thermophilus type strain (TK-6 T) 10.4056/sigs.1463589
Complete genome sequence of Thermosediminibacter oceani type strain (JW/IW-1228P T) 10.4056/sigs.1133078
Complete genome sequence of the gliding freshwater bacterium Fluviicola taffensis type strain (RW262 T) 10.4056/sigs.2124912
Complete genome sequence of Mesorhizobium opportunistum type strain WSM2075T 10.4056/sigs.4538264
Complete genome sequence of the sulfur compounds oxidizing chemolithoautotroph Sulfuricurvum kujiense type strain (YK-1 T) 10.4056/sigs.2456004
FOAM (Functional Ontology Assignments for Metagenomes): A Hidden Markov Model (HMM) database with environmental focus 10.1093/nar/gku702
Complete genome sequence of Intrasporangium calvum type strain (7 KIP T) 10.4056/sigs.1263355
Genome Analysis of Planctomycetes Inhabiting Blades of the Red Alga Porphyra umbilicalis 10.1371/journal.pone.0151883
Complete genome sequence of Brachybacterium faecium type strain (schefferle 6-10 T) 10.4056/sigs.492
High-quality draft genome sequence of the Opitutaceae bacterium strain TAV1, a symbiont of the wood-feeding termite Reticulitermes flavipes 10.1128/JB.00264-12
Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21 T) 10.4056/sigs.47643
Single-cell genomics reveals complex carbohydrate degradation patterns in poribacterial symbionts of marine sponges 10.1038/ismej.2013.111
Complete genome sequence of riemerella anatipestifer type strain (ATCC 11845 T) 10.4056/sigs.1553865
Complete genome sequence of Spirochaeta smaragdinae type strain (SEBR 4228 T) 10.4056/sigs.1143106
Genome sequence of the Trifolium rueppellianum -nodulating Rhizobium leguminosarum bv. trifolii strain WSM2012 10.4056/sigs.4528262
Genome sequence of the moderately thermophilic sulfur-reducing bacterium Thermanaerovibrio velox type strain (Z-9701T) and emended description of the genus Thermanaerovibrio 10.4056/sigs.4237901
Genome sequence of Frateuria aurantia type strain (Kondô 67T), a xanthomonade isolated from Lilium auratium Lindl 10.4056/sigs.4338002
Complete genome sequence of Sebaldella termitidis type strain (NCTC 11300 T) 10.4056/sigs.811799
Complete genome sequence of Cellulophaga lytica type strain (LIM-21 T) 10.4056/sigs.1774329
Draft genome sequence of the cellulolytic and xylanolytic thermophile Clostridium clariflavum strain 4-2a 10.1128/genomeA.00797-15
Complete genome sequence of Kribbella flavida type strain (IFO 14399 T) 10.4056/sigs.731321
Genome sequence of Stenotrophomonas maltophilia PML168, which displays baeyer-villiger monooxygenase activity 10.1128/JB.00949-12
Complete genome sequence of Arthrobacter phenanthrenivorans type strain (Sphe3) 10.4056/sigs.1393494
Complete genome sequence of Nitratifractor salsuginis type strain (E9I37-1T) 10.4056/sigs.1844518
The standard operating procedure of the DOE-JGI Microbial Genome Annotation Pipeline (MGAP v.4) 10.1186/s40793-015-0077-y
Complete genome sequence of Meiothermus ruber type strain (21 T) 10.4056/sigs.1032748
A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea 10.1038/nature08656
LmbE proteins from Bacillus cereus are de-N-acetylases with broad substrate specificity and are highly similar to proteins in Bacillus anthracis 10.1111/j.1742-4658.2010.07691.x
Complete genome sequence of Haloterrigena turkmenica type strain (4k T) 10.4056/sigs.681272
Complete genome sequence of Ferrimonas balearica type strain (PAT T) 10.4056/sigs.1161239
Complete genome sequence of Denitrovibrio acetiphilus type strain (N2460 T) 10.4056/sigs.892105
Complete genome sequence of the thermophilic sulfur-reducer Hippea maritima type strain (MH 2T) 10.4056/sigs.1814460
Complete genome sequence of Haliangium ochraceum type strain (SMP-2 T) 10.4056/sigs.69.1277
Complete genome sequence of Methanoplanus petrolearius type strain (SEBR 4847 T) 10.4056/sigs.1183143
Complete genome sequence of Desulfarculus baarsii type strain (2st14 T ) 10.4056/sigs.1243258
Genome sequence of Ensifer meliloti strain WSM1022; a highly effective microsymbiont of the model legume Medicago truncatula A17 10.4056/sigs.4608286
IMG/M-HMP: A metagenome comparative analysis system for the human microbiome project 10.1371/journal.pone.0040151
Comparative genomic analysis of phylogenetically closely related Hydrogenobaculum sp. isolates from yellowstone national park 10.1128/AEM.03591-12
Complete genome sequence of Arcanobacterium haemolyticum type strain (11018 T) 10.4056/sigs.1123072
Complete genome sequence of the termite hindgut bacterium Spirochaeta coccoides type strain (SPN1T), reclassification in the genus Sphaerochaeta as Sphaerochaeta coccoides comb. nov. and emendations of the family Spirochaetaceae and the genus Sphaerochaeta 10.4056/sigs.2796069
Complete genome sequence of Rhodospirillum rubrum type strain (S1 T) 10.4056/sigs.1804360
Complete genome sequence of Streptosporangium roseum type strain (NI 9100 T) 10.4056/sigs.631049
Complete genome sequence of Rhizobium leguminosarum bv trifolii strain WSM2304, an effective microsymbiont of the South American clover Trifolium polymorphum 10.4056/sigs.44642
Erratum to The standard operating procedure of the DOE-JGI Microbial Genome Annotation Pipeline (MGAP v.4) [Stand Genomic Sci, (2015), 10, 86] 10.1186/s40793-016-0148-8
Complete genome sequence of haliscomenobacter hydrossis type strain (O T) 10.4056/sigs.1964579
Complete genome sequence of Thermomonospora curvata type strain (B9 T) 10.4056/sigs.1453580
Comparing polysaccharide decomposition between the type strains Gramella echinicola KMM 6050 T (DSM 19838 T ) and Gramella portivictoriae UST040801-001 T (DSM 23547 T ), and emended description of Gramella echinicola Nedashkovskaya et al. 2005 emend. Shahina et al. 2014 and Gramella portivictoriae Lau et al. 2005 10.1186/s40793-016-0163-9
Complete genome sequence of Aminobacterium colombiense type strain (ALA-1 T) 10.4056/sigs.902116
Complete genome sequence of Olsenella uli type strain (VPI D76D-27C T) 10.4056/sigs.1082860
Complete genome sequence of the bile-resistant pigment-producing anaerobe alistipes finegoldii type strain (ahn2437T) 10.4056/sigs.3527032
Complete genome sequence of Segniliparus rotundus type strain (CDC 1076 T) 10.4056/sigs.791633
Complete genome sequence of Geodermatophilus obscurus type strain (g-20 T) 10.4056/sigs.711311
Complete genome sequence of Cellulophaga algicola type strain (IC166 T) 10.4056/sigs.1543845
Complete genome sequence of rhizobium leguminosarum bv. trifolii strain WSM1325, an effective microsymbiont of annual Mediterranean clovers 10.4056/sigs.852027
Complete genome sequence of the aquatic bacterium Runella slithyformis type strain (LSU 4T) 10.4056/sigs.2475579
Draft genome sequence of Halomonas lutea strain YIM 91125 T (DSM 23508 T ) isolated from the alkaline Lake Ebinur in Northwest China 10.1186/1944-3277-10-1
Complete genome sequence of the gliding, heparinolytic pedobacter saltans type strain (113 T) 10.4056/sigs.2154937
Complete genome sequence of Nakamurella multipartita type strain (Y-104 T) 10.4056/sigs.721316
The candidate phylum Poribacteria by single-cell genomics: New insights into phylogeny, cell-compartmentation, eukaryote-like repeat proteins, and other genomic features 10.1371/journal.pone.0087353
Complete genome sequence of Calditerrivibrio nitroreducens type strain (Yu37-1 T) 10.4056/sigs.1523807
The standard operating procedure of the DOE-JGI Metagenome Annotation Pipeline (MAP v.4) 10.1186/s40793-016-0138-x
Genome sequence of the moderately thermophilic halophile Flexistipes sinusarabici strain (MAS10t) 10.4056/sigs.2235024
Genome sequence of the Listia angolensis microsymbiont Microvirga lotononidis strain WSM3557T 10.4056/sigs.4548266
Genome sequence of Ensifer sp. TW10; a Tephrosia wallichii (Biyani) microsymbiont native to the Indian Thar Desert 10.4056/sigs.4598281
Complete genome sequence of odoribacter splanchnicus type strain (1651/6 T) 10.4056/sigs.1714269
Non-contiguous finished genome sequence of Bacteroides coprosuis type strain (PC139 T) 10.4056/sigs.1784330
Complete genome sequence of the Medicago microsymbiont Ensifer (Sinorhizobium) medicae strain WSM419 10.4056/sigs.43526
Non-contiguous finished genome sequence of the opportunistic oral pathogen Prevotella multisaccharivorax type strain (PPPA20 t) 10.4056/sigs.2164949
Complete genome sequence of acetohalobium Arabaticum type strain (Z-7288 T) 10.4056/sigs.1062906
Complete genome sequence of the moderately thermophilic mineral-sulfide-oxidizing firmicute Sulfobacillus acidophilus type strain (NAL T) 10.4056/sigs.2736042
Complete genome sequence of Bacteroides helcogenes type strain (P 36-108 T) 10.4056/sigs.1513795
Complete genome sequence of Desulfurococcus mucosus type strain (O7/1 T) 10.4056/sigs.1644004
High-quality-draft genome sequence of the yellow-pigmented flavobacterium joostella marina type strain (En5T) 10.4056/sigs.3537045
Metagenomes of tropical soil-derived anaerobic switchgrass-adapted consortia with and without iron 10.4056/sigs.3377516
Complete genome sequence of Vulcanisaeta distributa type strain (IC-017 T) 10.4056/sigs.1113067
Genome sequence of the fleming strain of Micrococcus luteus, a simple free-living actinobacterium 10.1128/JB.01254-09
The genome sequence of methanohalophilus mahii SLP(T) reveals differences in the energy metabolism among members of the methanosarcinaceae inhabiting freshwater and saline environments 10.1155/2010/690737
Estimating DNA coverage and abundance in metagenomes using a gamma approximation 10.1093/bioinformatics/btp687
Genome sequence and description of the anaerobic lignin-degrading bacterium Tolumonas lignolytica sp. nov. 10.1186/s40793-015-0100-3
Novel insights into the diversity of catabolic metabolism from ten haloarchaeal genomes 10.1371/journal.pone.0020237
Genome sequence of the filamentous, gliding Thiothrix nivea neotype strain (JP2 T) 10.4056/sigs.2344929
High quality draft genome sequence of Olivibacter sitiensis type strain (AW-6T), a diphenol degrader with genes involved in the catechol pathway 10.4056/sigs.5088950
One bacterial cell, one complete genome 10.1371/journal.pone.0010314
Permanent draft genome sequence of the gliding predator Saprospira grandis strain Sa g1 (= HR1) 10.4056/sigs.2816096
Complete genome sequence of Sanguibacter keddieii type strain (ST-74 T) 10.4056/sigs.16197
Complete genome sequences of Desulfosporosinus orientis DSM765T, Desulfosporosinus youngiae DSM17734T, Desulfosporosinus meridiei DSM13257T, and Desulfosporosinus acidiphilus DSM22704T 10.1128/JB.01392-12
Complete genome sequence of Isosphaera pallida type strain (IS1BT) 10.4056/sigs.1533840
Complete genome sequence of Chitinophaga pinensis type strain (UQM 2034 T) 10.4056/sigs.661199
Complete genome sequence of mahella australiensis type strain (50-1 BON T) 10.4056/sigs.1864526
Draft genome sequence of Pseudomonas azotifigens strain DSM 17556T (6H33bT), a nitrogen fixer strain isolated from a compost pile 10.1128/genomeA.00893-13
Permanent draft genome sequence of Dethiosulfovibrio peptidovorans type strain (SEBR 4207 T) 10.4056/sigs.1092865
Complete genome sequence of Desulfomicrobium baculatum type strain (X T) 10.4056/sigs.13134
Complete genome sequence of Thermanaerovibrio acidaminovorans type strain (Su883 T) 10.4056/sigs.40645
Complete genome sequence of Truepera radiovictrix type strain (RQ-24 T) 10.4056/sigs.1563919
Complete genome sequence of the extremely Halophilic Halanaerobium praevalens type strain (GSL T) 10.4056/sigs.1824509
Genome sequence of Ensifer medicae strain WSM1369; an effective microsymbiont of the annual legume Medicago sphaerocarpos 10.4056/sigs.4838624
Complete genome sequence of Weeksella virosa type strain (9751 T) 10.4056/sigs.1603927
Erratum to Complete genome sequence of Atopobium parvulum type strain (IPP 1246 T, ) (Standards in Genomic Sciences, (2010), 2, (361-362)) 10.4056/sigs.992408
High quality draft genome sequence of Flavobacterium rivuli type strain WB 3.3-2T (DSM 21788T), a valuable source of polysaccharide decomposing enzymes 10.1186/s40793-015-0032-y
Complete genome sequence of ignisphaera aggregans type strain (AQ1.S1 T) 10.4056/sigs.1072907
Complete genome sequence of the thermophilic sulfur-reducer Desulfurobacterium thermolithotrophum type strain (BSA T) from a deep-sea hydrothermal vent 10.4056/sigs.2465574
Genome sequence of the phylogenetically isolated spirochete Leptonema illini type strain (3055T) 10.4056/sigs.3637201
Genome sequence of the moderately thermophilic, amino-acid-degrading and sulfur-reducing bacterium Thermovirga lienii type strain (Cas60314T) 10.4056/sigs.2726028
Complete genome sequence of Gordonia bronchialis type strain (3410 T) 10.4056/sigs.611106
Genome sequence of the Thermotoga thermarum type strain (LA3T) from an African solfataric spring 10.4056/sigs.3016383
Genome sequence of the free-living aerobic spirochete Turneriella parva type strain (HT), and emendation of the species Turneriella parva 10.4056/sigs.3617113
Complete genome sequence of Veillonella parvula type strain (Te3 T) 10.4056/sigs.521107
Complete genome sequence of Sulfurospirillum deleyianum type strain (5175 T) 10.4056/sigs.671209
Genome sequence of the Lebeckia ambigua-nodulating "Burkholderia sprentiae" strain WSM5005T 10.4056/sigs.4558268
Genome sequence of Microvirga lupini strain LUT6T, a novel Lupinus alphaproteobacterial microsymbiont from Texas 10.4056/sigs.5249382
Complete genome sequence of Meiothermus silvanus type strain (vi-R2 T) 10.4056/sigs.1042812
Complete genome sequence of Desulfohalobium retbaense type strain (HR 100T) 10.4056/sigs.581048
Complete genome sequence of acidaminococcus fermentans type strain (VR4 T) 10.4056/sigs.1002553
Genome sequence of the muddwelling archaeon Methanoplanus limicola type strain (DSM 2279T), reclassification of Methanoplanus petrolearius as Methanolacinia petrolearia and emended descriptions of the genera Methanoplanus and Methanolacinia 10.4056/sigs.5138968
Complete genome sequence of the moderate thermophile anaerobaculum mobile type strain (NGAT) 10.4056/sigs.3547050
Comparative transcriptomics between Synechococcus PCC 7942 and Synechocystis PCC 6803 provide insights into mechanisms of stress acclimation 10.1371/journal.pone.0109738
Complete genome sequence of Methanothermus fervidus type strain (V24S T) 10.4056/sigs.1283367
Non-contiguous finished genome sequence of Aminomonas paucivorans type strain (GLU-3 T) 10.4056/sigs.1253298
Genome sequence of the South American clover-nodulating Rhizobium leguminosarum bv. trifolii strain WSM597 10.4056/sigs.4508258
Genome sequence of the clover-nodulating Rhizobium leguminosarum bv. trifolii strain SRDI565 10.4056/sigs.4468250
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509 T) 10.4056/sigs.1363462
Complete genome sequence of Paludibacter propionicigenes type strain (WB4 T) 10.4056/sigs.1503846
IMG: The integrated microbial genomes database and comparative analysis system 10.1093/nar/gkr1044
Non-contiguous finished genome sequence and contextual data of the filamentous soil bacterium Ktedonobacter racemifer type strain (SOSP1-21 T) 10.4056/sigs.2114901
Complete genome sequence of Alicyclobacillus acidocaldarius type strain (104-IA T) 10.4056/sigs.591104
Complete genome sequence of the thermophilic, hydrogen-oxidizing Bacillus tusciae type strain (T2 T) and reclassification in the new genus, Kyrpidia gen. nov. as Kyrpidia tusciae comb. nov. and emendation of the family alicyclobacillaceae da Costa and Rainey, 2010 10.4056/sigs.2144922
Complete genome sequence of the hyperthermophilic chemolithoautotroph Pyrolobus fumarii type strain (1A T) 10.4056/sigs.2014648
Complete genome sequence of the acetate-degrading sulfate reducer Desulfobacca acetoxidans type strain (ASRB2 T) 10.4056/sigs.2064705
Complete genome sequence of Sulfurimonas autotrophica type strain (OK10 T) 10.4056/sigs.1173118
Complete genome sequence of the thermophilic sulfate-reducing ocean bacterium Thermodesulfatator indicus type strain (CIR29812T) 10.4056/sigs.2665915
High quality draft genome sequence of the slightly halophilic bacterium Halomonas zhanjiangensis type strain JSM 078169T (DSM 21076T) from a sea urchin in southern China 10.4056/sigs.5449586
IMG/M: The integrated metagenome data management and comparative analysis system 10.1093/nar/gkr975
Complete genome sequence of the orange-red pigmented, radioresistant Deinococcus proteolyticus type strain (MRPT) 10.4056/sigs.2756060
IMG/M 4 version of the integrated metagenome comparative analysis system 10.1093/nar/gkt919
Complete genome sequence of Xylanimonas cellulosilytica type strain (XIL07 T) 10.4056/sigs.571102
Complete genome sequence of Saccharomonospora viridis type strain (P101 T) 10.4056/sigs.20263
Genome sequence of the Ornithopus/Lupinus-nodulating Bradyrhizobium sp. strain WSM471 10.4056/sigs.4498256
Genome sequence of the thermophilic fresh-water bacterium spirochaeta caldaria type strain (h1t), reclassification of spirochaeta caldaria, spirochaeta stenostrepta, and spirochaeta zuelzerae in the genus treponema as treponema caldaria comb. nov., treponema stenostrepta comb. nov., and treponema zuelzerae comb. nov., and emendation of the genus treponema 10.4056/sigs.3096473
Complete genome sequence of Syntrophobotulus glycolicus type strain (FlGlyR T) 10.4056/sigs.2004648
Complete genome sequence of Nitrosomonas sp. Is79, an ammonia oxidizing bacterium adapted to low ammonium concentrations 10.4056/sigs.3517166
Genome sequence of the orange-pigmented seawater bacterium Owenweeksia hongkongensis type strain (UST20020801T) 10.4056/sigs.3296896
Complete genome sequence of Thermaerobacter marianensis type strain (7p75a T) 10.4056/sigs.1373474
Complete genome sequence of coraliomargarita akajimensis type strain (04OKA010-24 T) 10.4056/sigs.952166
Genomes of three methylotrophs from a single niche reveal the genetic and metabolic divergence of the methylophilaceae 10.1128/JB.00404-11
The Fast Changing Landscape of Sequencing Technologies and Their Impact on Microbial Genome Assemblies and Annotation 10.1371/journal.pone.0048837
Complete genome sequence of Mesorhizobium australicum type strain (WSM2073T) 10.4056/sigs.4568282
Improving Microbial Genome Annotations in an Integrated Database Context 10.1371/journal.pone.0054859
Complete genome sequence of Clostridium clariflavum DSM 19732 10.4056/sigs.2535732
Complete genome sequence of Brachyspira murdochii type strain (56-150 T) 10.4056/sigs.831993
Genome sequence of the acid-tolerant Burkholderia sp. strain WSM2230 from Karijini National Park, Australia 10.4056/sigs.5008793
Complete genome sequence of marivirga tractuosa type strain (H-43 T) 10.4056/sigs.1623941
Complete genome sequence of Streptobacillus moniliformis type strain (9901 T) 10.4056/sigs.48727
Genome sequence of the Lotus spp. microsymbiont Mesorhizobium loti strain NZP2037 10.1186/1944-3277-9-7
Complete genome sequence of Sphaerobacter thermophilus type strain (S 6022 T) 10.4056/sigs.601105
Complete genome sequence of Thermosphaera aggregans type strain (M11TL T) 10.4056/sigs.821804
Complete genome sequence of oceanithermus profundus type strain (506 T) 10.4056/sigs.1734292
Complete genome sequence of Conexibacter woesei type strain (ID131577 T) 10.4056/sigs.751339
Genome sequence of the Lotus corniculatus microsymbiont Mesorhizobium loti strain R88B 10.1186/1944-3277-9-3
Genome sequence of the dark pink pigmented Listia bainesii microsymbiont Methylobacterium sp. WSM2598 10.1186/1944-3277-9-5
Genome sequence of the Lotus spp. microsymbiont Mesorhizobium loti strain R7A 10.1186/1944-3277-9-6
Complete genome sequence of 'Thermobaculum terrenum' type strain (YNP1 T) 10.4056/sigs.1153107
Complete genome sequence of "Thioalkalivibrio sulfidophilus" HL-EbGr7 10.4056/sigs.1483693
Complete genome sequence of Thermocrinis albus type strain (HI 11/12 T) 10.4056/sigs.761490
High quality draft genome sequence of brachymonas chironomi AIMA4<sup>T</sup> (DSM 19884<sup>T</sup>) isolated from a chironomus sp. egg mass 10.1186/s40793-015-0010-4
Complete genome sequence of "enterobacter lignolyticus" SCF1 10.4056/sigs.2104875
Complete genome sequence of planctomyces limnophilus type strain (mü 290 T ) 10.4056/sigs.1052813
Complete genome sequence of Desulfobulbus propionicus type strain (1pr3 T) 10.4056/sigs.1613929
Erratum to: Complete genome sequence of Pirellula staleyi type strain (ATCC 27377 T) 10.4056/sigs.88.1234
Complete genome sequence of Eggerthella lenta type strain (VPI 0255 T) 10.4056/sigs.33592
Complete genome sequence of the halophilic bacterium Spirochaeta africana type strain (Z-7692t) from the alkaline Lake Magadi in the East African Rift 10.4056/sigs.3607108
Complete genome sequence of Ilyobacter polytropus type strain (CuHbu1 T) 10.4056/sigs.1273360
Complete genome sequence of leadbetterella byssophila type strain (4M15 T) 10.4056/sigs.1413518
Complete genome sequence of Archaeoglobus profundus type strain (AV18 T) 10.4056/sigs.942153
Complete genome sequence of coriobacterium glomerans type strain (PW2T) from the midgut of pyrrhocoris apterus L. (red soldier bug) 10.4056/sigs.3507020
Complete genome sequence of Treponema succinifaciens type strain (6091 T) 10.4056/sigs.1984594
Roger Linington
Linington Roger / Roger G. Linington
ORCID: 0000-0003-1818-4971
Biofilm Formation and Detachment in Gram-Negative Pathogens Is Modulated by Select Bile Acids. 10.1371/journal.pone.0149603
The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes. 10.1074/jbc.M115.673210
Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries. 10.1073/pnas.1507743112
Phenotype-Guided Natural Products Discovery Using Cytological Profiling. 10.1021/acs.jnatprod.5b00455
Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. 10.1021/acschembio.5b00308
Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. 10.1021/acs.joc.5b01264
Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms. 10.1039/c5ob01134e
Living in the matrix: assembly and control of Vibrio cholerae biofilms. 10.1038/nrmicro3433
Connecting phenotype and chemotype: high-content discovery strategies for natural products research. 10.1021/acs.jnatprod.5b00017
Salinipostins A-K, long-chain bicyclic phosphotriesters as a potent and selective antimalarial chemotype. 10.1021/jo5024409
Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism. 10.1021/ol503349y
Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae. 10.1039/c4cc07003h
Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis. 10.1021/np500727g
A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. 10.1016/j.cell.2014.08.032
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. 10.1016/j.cell.2014.06.034
Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity. 10.1371/journal.pone.0084549
An NF-κB-based high-throughput screen identifies piericidins as inhibitors of the Yersinia pseudotuberculosis type III secretion system. 10.1128/AAC.02025-13
Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa. 10.1128/AAC.01781-13
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. 10.1038/ja.2013.99
Discovery and biological characterization of the auromomycin chromophore as an inhibitor of biofilm formation in Vibrio cholerae. 10.1002/cbic.201300131
Molecular networking as a dereplication strategy. 10.1021/np400413s
Mechanism of action-based classification of antibiotics using high-content bacterial image analysis. 10.1039/c3mb70027e
Development of quinoline-based disruptors of biofilm formation against Vibrio cholerae. 10.1021/ol400150z
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. 10.1021/np300834q
"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening. 10.1016/j.chembiol.2012.12.007
Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics. 10.1016/j.chembiol.2012.09.014
Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP. 10.1016/j.chembiol.2012.08.014
Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness. 10.1371/journal.pone.0046172
Chemical inhibitors of the type three secretion system: disarming bacterial pathogens. 10.1128/AAC.00975-12
Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products. 10.1371/journal.pone.0035398
Total synthesis, stereochemical assignment, and antimalarial activity of gallinamide A. 10.1002/chem.201102538
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. 10.1038/nchembio.664
Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants. 10.1016/j.bmc.2011.07.017
Versatile method for the detection of covalently bound substrates on solid supports by DART mass spectrometry. 10.1021/ol201404v
Expedient synthesis of α,α-dimethyl-β-hydroxy carbonyl scaffolds via Evans' aldol reaction with a tertiary enolate. 10.1016/j.tetlet.2011.03.126
An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae. 10.1039/c0mb00276c
Identification and characterization of a phosphodiesterase that inversely regulates motility and biofilm formation in Vibrio cholerae. 10.1128/JB.00209-10
Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. 10.1021/jm100265s
Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity. 10.1021/np900622m
Dereplication and de novo sequencing of nonribosomal peptides. 10.1038/nmeth.1350
New innovations for an old infection: antimalarial lead discovery from marine natural products during the period 2003-2008. 10.4155/fmc.09.56
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. 10.1021/ac900114t
Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. 10.1021/np8003529
Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp. 10.1021/np070280x
Linking bioprospecting with sustainable development and conservation: the Panama case 10.1007/s10531-007-9214-2
Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. 10.1021/np0700772
Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp. 10.1021/np0605790
Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia. 10.1021/np050192h
Stereochemical assignment in acyclic lipids across long distance by circular dichroism: absolute stereochemistry of the aglycone of caminoside A. 10.1002/anie.200461158
Latonduines A and B, new alkaloids isolated from the marine sponge Stylissa carteri: structure elucidation, synthesis, and biogenetic implications. 10.1021/ol034950b
Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia. 10.1021/ol0268337
Total Synthesis of Glycinocins A-C. 10.1021/acs.joc.7b01959
Total Synthesis of Skyllamycins A-C. 10.1002/chem.201704277
Data-analysis strategies for image-based cell profiling. 10.1038/nmeth.4397
Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high. 10.1073/pnas.1711139114
Retrospective analysis of natural products provides insights for future discovery trends. 10.1073/pnas.1614680114
Special Issue in Honor of Professor Phil Crews. 10.1021/acs.jnatprod.7b00161
Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. 10.1038/ncomms14414
Piericidin A1 Blocks Yersinia Ysc Type III Secretion System Needle Assembly. 10.1128/msphere.00030-17
Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure-activity relationship of anabaenopeptin protease inhibitors. 10.1016/j.bmcl.2016.09.008
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. 10.1038/nbt.3597
Erratum for Duncan et al., An NF-κB-Based High-Throughput Screen Identifies Piericidins as Inhibitors of the Yersinia pseudotuberculosis Type III Secretion System. 10.1128/aac.00973-16
Image-Based Screening Approaches to Natural Products Discovery 10.1002/9781118794623.ch20
De Novo Sequencing of Nonribosomal Peptides 10.1007/978-3-540-78839-3_16
De Novo terpenoid biosynthesis by the dendronotid nudibranch Melibe leonina 10.1007/pl00012669
The bioactive lipid (S)-sebastenoic acid impacts motility and dispersion in Vibrio cholerae 10.1139/cjc-2017-0334
Synthetic Studies Toward the Skyllamycins: Total Synthesis and Generation of Simplified Analogues 10.1021/acs.joc.8b00898
Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile. 10.1021/acsinfecdis.7b00105
A selective genome-guided method for environmental Burkholderia isolation. 10.1007/s10295-018-02121-x
Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source. 10.1002/anie.201805673
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. 10.1039/c7np00064b
Synthesis and evaluation of analogues of the glycinocin family of calcium-dependent antibiotics. 10.1039/c8ob01268g
Maculatic Acids-Sex Attractant Pheromone Components of Bald-Faced Hornets. 10.1002/anie.201804666
Cutibacterium acnes antibiotic production shapes niche competition in the human skin microbiome 10.1101/594010
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. 10.1039/c8np90041h
Problems in Organic Structure Determination 10.1201/b19329
MIBiG 2.0: a repository for biosynthetic gene clusters of known function 10.1093/nar/gkz882
High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling 10.1101/748129
Isolation, Structure Elucidation, and Total Synthesis of Dolichovespulide, a Sesquiterpene from Dolichovespula Yellowjackets 10.1021/acs.jnatprod.9b00238
Targeting tRNA-Synthetase Interactions towards Novel Therapeutic Discovery Against Eukaryotic Pathogens 10.1101/711697
New methods for isolation and structure determination of natural products 10.1039/c9np90023c
Development of a Custom MALDI-TOF Mass Spectrometric Database for Identification of Environmental Burkholderia and Related Genera. 10.1128/aem.00354-20
Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens. 10.1371/journal.pntd.0007983
The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites. 10.1016/j.chembiol.2020.01.001
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery. 10.1021/acscentsci.9b00806
A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles 10.1126/scitranslmed.aay5445
Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products. 10.1021/acschembio.0c00824
Microbial natural product databases: moving forward in the multi-omics era. 10.1039/d0np00053a
Jan Claesen
Claesen Jan
ORCID: 0000-0002-0755-7974
Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. 10.1371/journal.pbio.1000339
Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides. 10.1073/pnas.1008608107
Biosynthesis and regulation of grisemycin, a new member of the linaridin family of ribosomally synthesized peptides produced by Streptomyces griseus IFO 13350. 10.1128/JB.00171-11
Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters 10.1016/j.cell.2014.06.034
Propionibacterium-Produced Coproporphyrin III Induces Staphylococcus aureus Aggregation and Biofilm Formation 10.1128/mbio.01286-14
Synthetic microbes as drug delivery systems. 10.1021/sb500258b
Synthetic biology to access and expand nature's chemical diversity 10.1038/nrmicro.2015.24
Contextual control of skin immunity and inflammation by Corynebacterium 10.1084/jem.20171079
Topical Antiseptics and the Skin Microbiota 10.1016/j.jid.2018.06.001
The gut symbionts Lactobacillus reuteri R2lc and 2010 encode a polyketide synthase cluster that activates the mammalian aryl-hydrocarbon receptor. 10.1128/aem.01661-18
Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut 10.1038/s41564-019-0590-7
Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation 10.1101/2020.04.22.055939
Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy 10.1101/2020.06.16.155226
A Novel Surgical Method for Continuous Intra-Portal Infusion of Gut Microbial Metabolites in Mice 10.1101/2020.10.29.360628
A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles 10.1126/scitranslmed.aay5445
A surgical method for continuous intraportal infusion of gut microbial metabolites in mice 10.1172/jci.insight.145607
Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation 10.1038/s41522-021-00226-3
Summary of the Sussex-Huawei locomotion-transportation recognition challenge
Observation of a manifold in the chaotic phase space of an asymmetric optical microcavity
Localized temporal variation of Earth's inner-core boundary from high-quality waveform doublets
Off-axis multi-wavelength dispersion controlling metalens for multi-color imaging
Impact of United States political sanctions on international collaborations and research in Iran