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Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

Marion, Estelle Song, Ok-Ryul Christophe, Thierry Babonneau, Jeremie Fenistein, Denis Eyer, Joel Letournel, Frank Henrion, Daniel Clere, Nicolas Paille, Vincent Guerineau, Nathalie C. Saint Andre, Jean-Paul Gersbach, Philipp Altmann, Karl-Heinz Stinear, Timothy Paul Comoglio, Yannick Sandoz, Guillaume Preisser, Laurence Delneste, Yves Yeramian, Edouard Marsollier, Laurent Brodin, Priscille

Cell, 2014

https://doi.org/10.1016/j.cell.2014.04.040

Nathalie Guerineau

Guerineau Nathalie

ORCID: 0000-0003-2517-4210

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Timothy Stinear

Stinear Timothy

ORCID: 0000-0003-0150-123X

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In vivo imaging of bioluminescent Mycobacterium ulcerans: A tool to refine the murine buruli ulcer tail model 10.4269/ajtmh.18-0959

Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease 10.1038/srep17693

Analysis of the Vaccine Potential of Plasmid DNA Encoding Nine Mycolactone Polyketide Synthase Domains in Mycobacterium ulcerans Infected Mice 10.1371/journal.pntd.0002604

Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry 10.1039/b506835e

Comparative Transcriptomic and Functional Assessments of Linezolid-Responsive Small RNA Genes in Staphylococcus aureus. 10.1128/mSystems.00665-19

Vaccine-specific immune responses against Mycobacterium ulcerans infection in a low-dose murine challenge model. 10.1128/iai.00753-19

Mining Symbionts of Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones. 10.1002/anie.201916007

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. 10.1371/journal.ppat.1008287

Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia 10.1101/856955

Secreted TAL effectors protect symbiotic bacteria from entrapment within fungal hyphae 10.1101/2020.03.28.013177

Genomics‐Driven Discovery of NO‐Donating Diazeniumdiolate Siderophores in Diverse Plant‐Associated Bacteria 10.1002/ange.201906326

Mining Symbionts of a Spider‐Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones 10.1002/ange.201916007

YycH and YycI Regulate Expression of Staphylococcus aureus Autolysins by Activation of WalRK Phosphorylation 10.3390/microorganisms8060870

Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia 10.1074/jbc.RA120.013528

Small RNA directs symbiosis, virulence, and natural products biosynthesis in entomopathogenic bacteria 10.1101/2020.08.24.265355

Systematic analysis of key parameters for genomics-based real-time detection and tracking of multidrug-resistant bacteria 10.1101/2020.09.24.310821

Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA 10.1038/s41564-020-00797-5

From cloning to mutant in 5 days: rapid allelic exchange in Staphylococcus aureus 10.1099/acmi.0.000193

Intracellular Staphylococcus aureus and host cell death pathways 10.1111/cmi.13317

Systematic review of M. Bovis BCG and other candidate vaccines for Buruli ulcer prophylaxis 10.1016/j.vaccine.2021.05.092

Significant Variability exists in the Toxicity of Global Methicillin-resistant Staphylococcus aureus Lineages 10.1101/2021.07.16.452633

Bacterial endosymbionts protect beneficial soil fungus from nematode attack 10.1073/pnas.2110669118

Low-Cost, Open-Source Device for High-Performance Fluorescence Detection of Isothermal Nucleic Acid Amplification Reactions 10.1021/acsbiomaterials.1c01105

Daniel Henrion

Henrion Daniel

ORCID: 0000-0003-1094-0285

http://mitovasc.univ-angers.fr

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Laser speckle contrast imaging: Multifractal analysis of data recorded in healthy subjects 10.1118/1.4748506

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Human serum albumin improves endothelial dysfunction and survival during experimental endotoxemia: Concentration-dependent properties 10.1097/CCM.0b013e318211ff6e

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Excessive microvascular adaptation to changes in blood flow in mice lacking gene encoding for desmin 10.1161/01.ATV.0000032652.24932.1A

Increase in cardiac ischemia-reperfusion injuries in Opa1^+/- mouse model 10.1371/journal.pone.0164066

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure 10.1038/nm.2079

Increased cerebral blood flow velocities assessed by transcranial Doppler examination is associated with complement activation after cardiopulmonary bypass 10.1177/0267659110392439

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In vitro protection of vascular function from oxidative stress and inflammation by pulsatility in resistance arteries 10.1016/j.jtcvs.2011.07.007

High-protein-low-carbohydrate diet: Deleterious metabolic and cardiovascular effects depend on age 10.1152/ajpheart.00291.2014

15th annual meeting of the European Council for Cardiovascular Research (ECCR) 10.1586/erc.10.178

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The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model 10.1016/j.bbadis.2016.10.028

Effects of chronic losartan treatment on vascular reactivity in normotensive rats 10.1097/00004872-199715050-00008

Determinants of flow-mediated outward remodeling in female rodents: Respective roles of age, estrogens, and timing 10.1161/ATVBAHA.114.303404

Chronic infusion of low-dose angiotensin II potentiates the adrenergic response in vivo 10.1097/00004872-199602000-00005

Myocardial reperfusion injury management: Erythropoietin compared with postconditioning 10.1152/ajpheart.00472.2009

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation 10.15252/emmm.201404112

Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release 10.1096/fj.07-8079com

Blood Pressure, the Renin‐angiotensin System and Neurogenic Vasoconstriction in Pithed Rats 10.1111/j.2042-7158.1989.tb06362.x

Preproendothelin-1 gene polymorphism is related to a change in vascular reactivity in the human mammary artery in vitro 10.1161/hy0202.103442

Cyclooxygenase-2-derived prostanoids reduce inward arterial remodeling induced by blood flow reduction in old obese Zucker rat mesenteric arteries 10.1016/j.vph.2013.03.001

Disseminated arterial calcification and enhanced myogenic response are associated with Abcc6 deficiency in a mouse model of pseudoxanthoma elasticum 10.1161/ATVBAHA.113.302943

Cyclooxygenase-2 preserves flow-mediated remodelling in old obese zucker rat mesenteric arteries 10.1093/cvr/cvp411

Activation of prostaglandin E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes 10.1093/cvr/cvp098

Adaptation of resistance arteries to chronic changes in blood flow: Outcome with respect to age and associated risk factors | Adaptation des artères de résistance aux variations chroniques de débit sanguin: Évolution avec l'âge et les facteurs de risque associés 10.1684/stv.2011.0655

Vimentin expression influences flow dependent VASP phosphorylation and regulates cell migration and proliferation 10.1016/j.bbrc.2010.04.033

Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice 10.1002/path.3960

Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy 10.1161/01.STR.0000149949.92854.45

AMPK Alpha 1-induced RhoA phosphorylation mediates vasoprotective effect of estradiol 10.1161/ATVBAHA.111.228304

Antithrombotic effects of hydroxychloroquine in primary antiphospholipid syndrome patients 10.1111/jth.12363

Systemic and immune manifestations in myelodysplasia: A multicenter retrospective study 10.1002/acr.20504

Central Role of P2Y 6 UDP Receptor in Arteriolar Myogenic Tone 10.1161/ATVBAHA.116.307739

The deletion genotype of the angiotensin I-converting enzyme is associated with an increased vascular reactivity in vivo and in vitro 10.1016/S0735-1097(99)00299-5

Selective involvement of serum response factor in pressure-induced myogenic tone in resistance arteries 10.1161/ATVBAHA.112.300708

Arterial stiffness and stroke in sickle cell disease 10.1161/STROKEAHA.111.635383

Effects of red wine polyphenols on postischemic neovascularization model in rats: Low doses are proangiogenic, high doses anti-angiogenic 10.1096/fj.06-7782com

Angiotensin II type 1 receptor gene polymorphism is associated with an increased vascular reactivity in the human mammary artery in vitro 10.1159/000025605

Effects of long-term active immunization with the second extracellular loop of human β1- or β3-adrenoceptors in thoracic aorta and mesenteric arteries in Lewis rats 10.1016/j.vph.2016.09.004

Cyclooxygenase-2 inhibition restored endothelium-mediated relaxation in old obese Zucker rat mesenteric arteries 10.3389/fphys.2010.00145

Hyperhomocysteinemia is not a cause of calcific aortic valves 10.1016/S0002-9149(00)00978-4

Increased contribution of L-arginine-nitric oxide pathway in aorta of mice lacking the gene for vimentin 10.1097/00005344-200110000-00007

p38 mitogen-activated protein kinase activation is required for thromboxane-induced contraction in perfused and pressurized rat mesenteric resistance arteries 10.1159/000065547

Carotid arterial stiffness, elastic fibre network and vasoreactivity in semicarbazide-sensitive amine-oxidase null mouse 10.1016/j.cardiores.2006.08.008

AGEs breaking and antioxidant treatment improves endothelium-dependent dilation without effect on flow-mediated remodeling of resistance arteries in old Zucker diabetic rats 10.1186/1475-2840-13-55

The AGE-breaker ALT-711 restores high blood flow-dependent remodeling in mesenteric resistance arteries in a rat model of type 2 diabetes 10.2337/db11-0750

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41 10.1038/ncomms12098

Decrease in endothelium-dependent relaxation in the mesenteric arterial bed following vascular calcium overload produced by vitamin D3 and nicotine in rats 10.1016/0024-3205(91)90256-B

Nucleoside triphosphate diphosphohydrolase-1 ectonucleotidase is required for normal vas deferens contraction and male fertility through maintaining P2X1 receptor function 10.1074/jbc.M114.604082

Ste20-related kinase SLK phosphorylates serl88 of RhoA to induce vasodilation in response to angiotensin II type 2 receptor activation 10.1161/CIRCRESAHA.107.164764

Chronic decrease in flow contributes to heart failure-induced endothelial dysfunction in rats 10.1111/j.1440-1681.2004.03997.x

Role of microvascular tone and extracellular matrix contraction in the regulation of interstitial fluid: Implications for aortic dissection 10.1161/ATVBAHA.116.307909

Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: Improvement by a treatment with hydralazine 10.1093/cvr/cvm055

AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade 10.1161/01.HYP.0000033224.99806.8A

Chronic hydralazine improves flow (shear stress)-induced endothelium-dependent dilation in mouse mesenteric resistance arteries in vitro 10.1006/mvre.2002.2417

Small changes in extracellular sodium influence myogenic tone in rabbit facial vein by changing its sensitivity to calcium 10.1016/S0024-3205(96)00653-4

Molecular insights into the transmembrane domain of the thyrotropin receptor 10.1371/journal.pone.0142250

Emerging role of G protein-coupled receptors in microvascular myogenic tone 10.1093/cvr/cvs152

Reactive oxygen species are necessary for high flow (shear Stress)-induced diameter enlargement of rat resistance arteries 10.1080/10739680902816301

The angiotensin II type 2 receptor activates flow-mediated outward remodelling through T cells-dependent interleukin-17 production 10.1093/cvr/cvw172

The vascular phenotype in pseudoxanthoma elasticum and related disorders: Contribution of a genetic disease to the understanding of vascular calcification 10.3389/fgene.2013.00004

Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats 10.1186/cc9257

Recombinant human activated protein C improves endotoxemia-induced endothelial dysfunction: A blood-free model in isolated mouse arteries 10.1152/ajpheart.01133.2008

Uterine artery structural and functional changes during pregnancy in tissue kallikrein-deficient mice 10.1161/01.ATV.0000090672.07568.60

Role of angiotensin II in the remodeling induced by a chronic increase in flow in rat mesenteric resistance arteries 10.1161/HYPERTENSIONAHA.108.127456

Involvement of RhoA/Rho kinase pathway in myogenic tone in the rabbit facial vein 10.1161/01.HYP.0000164582.63421.2d

Functional adaptation and remodeling of arteries to hemodynamic forces: Role of reactive oxygen species and the vascular renin-angiotensin system 10.1007/978-3-642-30018-9_71

Time-related alteration in flow-(shear stress-) mediated remodeling in resistance arteries from spontaneously hypertensive rats 10.1155/2014/859793

Clinical use of laser speckle techniques: Beyond the sole mapping 10.1007/s11517-012-0942-4

A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus 10.1161/HYPERTENSIONAHA.112.192500

Smooth muscle dysfunction in resistance arteries of the staggerer mouse, a mutant of the nuclear receptor RORα 10.1161/01.RES.0000014489.24705.71

RhoA activation and interaction with Caveolin-1 are critical for pressure-induced myogenic tone in rat mesenteric resistance arteries 10.1016/j.cardiores.2006.10.020

Role of the cytoskeleton in flow (shear stress)-induced dilation and remodeling in resistance arteries 10.1007/s11517-008-0306-2

The role of endogenous norepinephrine release in potassium-evoked vasoconstriction of the rat tail artery 10.1016/0014-2999(91)90771-H

The contribution of arterial calcification to peripheral arterial disease in pseudoxanthoma elasticum 10.1371/journal.pone.0096003

Increased calcium 45 fluxes in histologically abnormal human ascending aorta 10.1016/S0022-5223(98)70463-5

Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: The endothelial link 10.1038/sj.embor.7400916

COX-2-Derived Prostanoids and Oxidative Stress Additionally Reduce Endothelium-Mediated Relaxation in Old Type 2 Diabetic Rats 10.1371/journal.pone.0068217

Anti-Ku antibodies: Clinical, genetic and diagnostic insights 10.1016/j.autrev.2010.05.020

Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke 10.1093/eurheartj/eht153

Key role of estrogens and endothelial estrogen receptor α in blood flow-mediated remodeling of resistance arteries 10.1161/ATVBAHA.112.300334

Deficiency or blockade of angiotensin II type 2 receptor delays tumorigenesis by inhibiting malignant cell proliferation and angiogenesis 10.1002/ijc.25234

Resveratrol induces a mitochondrial complex i-dependent increase in nadh oxidation responsible for sirtuin activation in liver cells 10.1074/jbc.M113.466490

Assembly defects induce oxidative stress in inherited mitochondrial complex I deficiency 10.1016/j.biocel.2015.05.017

Prognosis of vasculitis associated myelodysplasia 10.1016/j.autrev.2013.01.005

Long lasting microvascular tone alteration in rat offspring exposed in utero to maternal hyperglycaemia 10.1371/journal.pone.0146830

Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice. 10.1161/ATVBAHA.112.249318

Inactivation of serum response factor contributes to decrease vascular muscular tone and arterial stiffness in mice 10.1161/CIRCRESAHA.113.301076

Absence of Dystrophin in Mice Reduces NO-Dependent Vascular Function and Vascular Density: Total Recovery after a Treatment with the Aminoglycoside Gentamicin 10.1161/01.ATV.0000118683.99628.42

Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions with an Arterial Function Improvement in Old Mice 10.1093/gerona/glv071

Commentary: Meeting report: Highlights of the 8th International Symposium on Resistance Arteries 10.1152/ajpheart.00832.2004

In utero exposure to maternal diabetes impairs vascular expression of prostacyclin receptor in rat offspring 10.2337/db10-0311

Key role of α1β1-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries 10.1152/ajpheart.00966.2006

Mutation of the palmitoylation site of estrogen receptor a in vivo reveals tissue-specific roles for membrane versus nuclear actions 10.1073/pnas.1322057111

Genetic determinants of vascular reactivity 10.1007/s11906-002-0052-z

Metabolically induced heteroplasmy shifting and l-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS 10.1016/j.bbadis.2012.01.010

Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries 10.1161/ATVBAHA.108.171751

Differences between the in vitro vasoconstrictor responses of the tail artery to potassium and norepinephrine between spontaneously hypertensive, renovascular hypertensive, and various strains of normotensive rats 10.1016/0160-5402(91)90023-X

Heme oxygenase-1 induction restores high-blood-flow-dependent remodeling and endothelial function in mesenteric arteries of old rats 10.1097/HJH.0b013e32833db36e

Resveratrol improved flow-mediated outward arterial remodeling in ovariectomized rats with hypertrophic effect at high dose 10.1371/journal.pone.0146148

Defect in microvascular adaptation to chronic changes in blood flow in mice lacking the gene encoding for dystrophin 10.1161/01.RES.0000047505.11002.81

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Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis 10.1242/dev.045351

Indapamide improves flow-induced dilation in hypertensive rats with a high salt intake 10.1097/00004872-199816100-00013

Endothelial kinin B1-receptors are induced by myocardial ischaemia-reperfusion in the rabbit 10.1111/j.1469-7793.2001.0069m.x

Detrimental hemodynamic and inflammatory effects of microparticles originating from septic rats 10.1097/CCM.0b013e3181a00629

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Vascular angiotensin AT2 receptors in hypertension and ageing 10.1111/j.1440-1681.2008.04883.x

Arterial Myogenic Activation through Smooth Muscle Filamin A 10.1016/j.celrep.2016.02.019

Involvement of angiotensin II in the remodeling induced by a chronic decrease in blood flow in rat mesenteric resistance arteries 10.1038/hr.2010.83

Role of estrogens and age in flow-mediated outward remodeling of rat mesenteric resistance arteries 10.1152/ajpheart.00986.2013

Is ABCC6 a genuine mitochondrial protein? 10.1186/1756-0500-6-427

In vitro vasoconstriction induced by calcium in renovascular hypertensive or old rats 10.1016/0024-3205(90)90215-D

Relationship between ankle brachial index and arterial remodeling in pseudoxanthoma elasticum 10.1016/j.jvs.2011.04.041

Mycobacterial toxin induces analgesia in Buruli ulcer by targeting the angiotensin pathways 10.1016/j.cell.2014.04.040

Mitogen-activated protein kinase cascade, endothelial function and vasomotor tone in the spontaneously hypertensive rat 10.1097/00004872-200206000-00007

WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice 10.1161/HYPERTENSIONAHA.111.172429

Flow (shear stress)-mediated remodeling of resistance arteries in diabetes 10.1016/j.vph.2012.03.006

Chronic blockade of endothelin ET(A) receptors improves flow dependent dilation in resistance arteries of hypertensive rats 10.1016/S0008-6363(98)00151-5

Diabetes mellitus abrogates erythropoietin-induced cardioprotection against ischemic-reperfusion injury by alteration of the RISK/GSK-3β signaling 10.1007/s00395-010-0130-3

Further evidence from an elastic artery that angiotensin II amplifies noradrenaline-induced contraction through activation of protein kinase C 10.1016/0014-2999(92)94812-A

Evaluation of the microcirculation in hypertension and cardiovascular disease 10.1093/eurheartj/ehm448

The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure 10.1096/fj.09-147926

Endothelial nitric oxide synthase lies downstream from angiotensin II-induced angiogenesis in ischemic hindlimb 10.1161/hy0302.104671

High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats 10.1161/01.CIR.0000156503.62815.48

Why do we need a selective angiotensin II type 2 receptor agonist? 10.1161/HYPERTENSIONAHA.112.197046

RISK and SAFE signaling pathway interactions in remote limb ischemic perconditioning in combination with local ischemic postconditioning 10.1007/s00395-011-0210-z

Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats 10.1161/HYPERTENSIONAHA.106.085035

The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27 10.1080/2162402X.2016.1178025

Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow 10.1093/cvr/cvn334

Dihydrochalcones: Implication in resistance to oxidative stress and bioactivities against advanced glycation end-products and vasoconstriction 10.1016/j.phytochem.2009.11.004

A 5-year prospective follow-up study in essential cryofibrinogenemia patients 10.1016/j.autrev.2011.04.009

Key role of the NO-pathway and matrix metalloprotease-9 in high blood flow-induced remodeling of rat resistance arteries 10.1161/01.ATV.0000254684.80662.44

Flow-induced remodeling in resistance arteries from obese Zucker rats is associated with endothelial dysfunction 10.1161/HYPERTENSIONAHA.107.088716

Optimisation of movement detection and artifact removal during laser speckle contrast imaging 10.1016/j.mvr.2014.09.005

Reactive oxygen species and cyclooxygenase 2-derived thromboxane A2 reduce angiotensin II type 2 receptor vasorelaxation in diabetic rat resistance arteries 10.1161/HYPERTENSIONAHA.109.140236

Chronic endothelin-1-induced changes in vascular reactivity in rat resistance arteries and aorta 10.1016/S0014-2999(98)00616-5

Estrogens are needed for the improvement in endothelium-mediated dilation induced by a chronic increase in blood flow in rat mesenteric arteries 10.1016/j.vph.2015.10.004

Dll4-notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models 10.1242/dev.092304

Microvascular vasodilator properties of the angiotensin II type 2 receptor in a mouse model of type 1 diabetes {10.1038/srep45625}

The endothelial aENaC contributes to vascular endothelial function in vivo {10.1371/journal.pone.0185319}

MEMBRANE AND NUCLEAR ESTROGEN RECEPTOR ALPHA ACTIONS: FROM TISSUE SPECIFICITY TO MEDICAL IMPLICATIONS {10.1152/physrev.00024.2016}

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone {10.3390/toxins9070227}

Testosterone Prevents Cutaneous Ischemia and Necrosis in Males Through Complementary Estrogenic and Androgenic Actions {10.1161/ATVBAHA.117.309219}

Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid (PlasmaLyte (R)) in a rat model with severe sepsis {10.1186/s13613-017-0286-1}

Iron deficiency without anemia is responsible for decreased left ventricular function and reduced mitochondrial complex I activity in a mouse model. 10.1016/j.ijcard.2018.02.021

Primary antiphospholipid syndrome and antiphospholipid syndrome associated to systemic lupus: Are they different entities? 10.1016/j.autrev.2018.01.027

In Utero Exposure to Maternal Diabetes Is Associated With Early Abnormal Vascular Structure in Offspring. 10.3389/fphys.2018.00350

GPR68 Senses Flow and Is Essential for Vascular Physiology. 10.1016/j.cell.2018.03.076

Alteration of Extracellular Nucleotide Metabolism in Pseudoxanthoma Elasticum. 10.1016/j.jid.2018.02.023

The accumulation of assembly intermediates of the mitochondrial complex I matrix arm is reduced by limiting glucose uptake in a neuronal-like model of MELAS syndrome. 10.1016/j.bbadis.2018.02.005

Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension. 10.1007/s11302-017-9597-9

Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. 10.1038/cddis.2016.327

Evolution of chemokine receptors is driven by mutations in the sodium binding site. 10.1371/journal.pcbi.1006209

The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases 10.3390/ijms21093244

Estrogens and the Angiotensin II Type 2 Receptor Control Flow-Mediated Outward Remodeling in the Female Mouse Mesenteric Artery 10.1159/000511799

Pathophysiological adaptations of resistance arteries in rat offspring exposed in utero to maternal obesity is associated with sex-specific epigenetic alterations 10.1038/s41366-021-00777-7

In vitro effects of the endocrine disruptor p,p'DDT on human choriogonadotropin/luteinizing hormone receptor signalling 10.1007/s00204-021-03007-1

ABCC6 deficiency promotes dyslipidemia and atherosclerosis 10.1038/s41598-021-82966-y

Author's reply (in reference to letter to editor proposed by Etem Caliskan, Catherine J. Pachuk, Louis P. Perrault, Maximilian Y Emmert and entitled: preservation solutions to improve graft patency: The devil is in the detail) 10.1186/s13019-021-01391-4

Bios2cor: an R package integrating dynamic and evolutionary correlations to identify functionally important residues in proteins 10.1093/bioinformatics/btab002

Endothelial S1P<sub>1</sub> Signaling Counteracts Infarct Expansion in Ischemic Stroke 10.1161/circresaha.120.316711

Flow-mediated outward arterial remodeling in aging 10.1016/j.mad.2020.111416

Deciphering collaborative sidechain motions in proteins during molecular dynamics simulations 10.1038/s41598-020-72766-1

Cardiopulmonary bypass and internal thoracic artery: Can roller or centrifugal pumps change vascular reactivity of the graft? The IPITA study: A randomized controlled clinical trial 10.1371/journal.pone.0235604

Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cells 10.1161/circresaha.120.317062

Metabolomic Profiling of Plasma and Erythrocytes in Sickle Mice Points to Altered Nociceptive Pathways 10.3390/cells9061334

Mutation of Arginine 264 on ERα (Estrogen Receptor Alpha) Selectively Abrogates the Rapid Signaling of Estradiol in the Endothelium Without Altering Fertility 10.1161/atvbaha.120.314159

Iron Deficiency without Anemia Decreases Physical Endurance and Mitochondrial Complex I Activity of Oxidative Skeletal Muscle in the Mouse 10.3390/nu13041056

DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries. 10.1371/journal.pone.0248554

Snake Venom Components: Tools and Cures to Target Cardiovascular Diseases 10.3390/molecules26082223

Partial Agonist Activity of Neonicotinoids on Rat Nicotinic Receptors: Consequences over Epinephrine Secretion and In Vivo Blood Pressure 10.3390/ijms22105106

Peripheral post-ischemic vascular repair is impaired in a murine model of Alzheimer’s disease 10.1007/s10456-018-9608-7

Evidence of Cardiovascular Calcification and Fibrosis in Pseudoxanthoma Elasticum Mouse Models Subjected to DOCA-Salt Hypertension 10.1038/s41598-019-52808-z

Priscille Brodin

Brodin Priscille

ORCID: 0000-0003-0991-7344

Email: priscille.brodin@inserm.fr

How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011

Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227 10.3390/toxins9070227.

Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections 10.2217/nnm-2016-0364

Cyclodextrin-based nanocarriers containing a synergic drug combination: a potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030 10.1016/j.ijpharm.2017.05.030.

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z

Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005 10.1016/j.drudis.2017.05.005.

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Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis 10.1016/j.tube.2004.09.009

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Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468

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CD8(+)-T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family 10.1128/iai.71.12.7173-7177.2003

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Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides 10.1021/bi015732y

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x

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Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides 10.1080/07328319908044831

Optimization of alternate-strand triple helix formation at the 5 '-TpA-3 ' and 5 '-ApT-3 ' junctions 10.1093/nar/27.15.3029

A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus 10.1074/jbc.272.25.16010

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114

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Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091

Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017 10.1016/j.mib.2017.11.017.

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101 10.1016/j.celrep.2017.08.101.

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114 10.1073/pnas.1707840114.

Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry 10.1128/jvi.01982-17

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125

Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025

Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation 10.3389/fimmu.2018.00086

Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis 10.1128/aac.00359-18

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4

Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030

Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101

Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129

A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening 10.1002/cyto.a.20627

Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360

Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation 10.1074/mcp.RA119.001316

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902

Mitochondrial Dynamics and Activity in Legionella-Infected Cells 10.1007/978-1-4939-9048-1_13

Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258

Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication 10.1128/jvi.02009-18

A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J

Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls 10.3390/toxins11090516

Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies. 10.3389/fimmu.2020.569127

Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity. 10.1021/acsinfecdis.9b00277

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds. 10.1371/journal.pone.0227224

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis. 10.1016/j.vaccine.2019.11.085

IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551

Worms' Antimicrobial Peptides. 10.3390/md17090512

T(oo)bAd. 10.1038/s41589-019-0347-x

Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. 10.1371/journal.pone.0198226

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g

Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38

Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82

Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570

Cell microbiology interview 10.1111/cmi.13288

Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505

franck letournel

letournel franck

ORCID: 0000-0003-2925-4453

Human subiculo-fornico-mamillary system in Alzheimer’s disease: Tau seeding by the pillar of the fornix 10.1007/s00401-019-02108-7

Metabolomics reveals highly regional specificity of cerebral sexual dimorphism in mice 10.1016/j.pneurobio.2019.101698

Neurofilaments form flexible bundles during neuritogenesis in culture and in mature axons in situ 10.1002/jnr.24482

Increased prevalence of granulovacuolar degeneration in C9orf72 mutation 10.1007/s00401-019-02028-6

Melanoma tumour vasculature heterogeneity: from mice models to human 10.1007/s00432-018-2809-z

Abundant electrical myotonia and left ventricular noncompaction: Unusual features of Danon disease due to a novel mutation in LAMP2 gene 10.1016/j.neurol.2018.04.012

New Antibody-Free Mass Spectrometry-Based Quantification Reveals That C9ORF72 Long Protein Isoform Is Reduced in the Frontal Cortex of Hexanucleotide-Repeat Expansion Carriers 10.3389/fnins.2018.00589

Immunohistochemical Method and Histopathology Judging for the Systemic Synuclein Sampling Study (S4) 10.1093/jnen/nly056

Interrupted CAG expansions in ATXN2 gene expand the genetic spectrum of frontotemporal dementias 10.1186/s40478-018-0547-8

Mitochondrial complex I defect resulting from exercise-induced lower limb ischemia in patients with peripheral arterial disease 10.1152/japplphysiol.00059.2018

The accumulation of assembly intermediates of the mitochondrial complex I matrix arm is reduced by limiting glucose uptake in a neuronal-like model of MELAS syndrome 10.1016/j.bbadis.2018.02.005

Primary fibroblasts derived from sporadic amyotrophic lateral sclerosis patients do not show ALS cytological lesions 10.1080/21678421.2018.1431787

5-Oxoprolinuria in hyperammonemic encephalopathy: Coincidence or worsening factor? 10.1016/j.clinbiochem.2017.09.025

Myoadenylate deaminase deficiency: a frequent cause of muscle pain A case detected by exercise testing 10.1684/abc.2017.1253

Therapeutic plasma exchange in chronic dysimmune peripheral neuropathies: A 10-year retrospective study 10.1002/jca.21530

Expanding the spectrum of congenital myopathy linked to recessive mutations in SCN4A 10.1212/wnl.0000000000003535

Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson’s Disease and Control Subjects 10.3233/JPD-160888

Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies 10.1186/s40478-016-0305-8

Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System 10.3233/JPD-150670

RISK and SAFE Signaling Pathway Involvement in Apolipoprotein A-I-Induced Cardioprotection 10.1371/journal.pone.0107950

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040

Démences : où sont les corps de Lewy ? 10.1016/j.neurol.2013.05.004

Diagnostic value of minor salivary glands biopsy for the detection of Lewy pathology 10.1016/j.neulet.2013.07.016

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome 10.1002/ana.23894

Axonal regeneration is compromised in NFH-LacZ transgenic mice but not in NFH-GFP mice 10.1016/j.neuroscience.2012.10.011

Necrotizing vasculitis revealed in a case of multiple mononeuropathy after a 14-year course of spontaneous remissions and relapses 10.1016/j.clineuro.2011.10.030

Photo-responsive polymer with erasable and reconfigurable micro- and nano-patterns: An in vitro study for neuron guidance 10.1016/j.colsurfb.2011.06.005

Chronic inflammatory demyelinating polyneuropathy in Waldenström's macroglobulinemia 10.1016/j.neurol.2010.10.015

Nemaline bodies as unique pathological feature in the course of treated dermatomyositis 10.5414/npp29357

Prise en charge des biopsies musculaires et nerveuses. Recommandations formalisées d’experts sous l’égide de la Société française de neuropathologie, de la Société française de myologie et de l’Association française contre les myopathies 10.1016/j.neurol.2010.03.015

Correction: Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer 10.1371/annotation/1e664e6f-3fc8-4586-a84e-73c4ec4f783f

Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity 10.1016/j.mito.2009.11.004

Neurofilament cross-bridging competes with kinesin-dependent association of neurofilaments with microtubules 10.1242/jcs.051318

Wernicke encephalopathy and Creutzfeldt-Jakob disease 10.1007/s00415-009-5038-1

Mitochondrial complex I deficiency in GDAP1-related autosomal dominant Charcot-Marie-Tooth disease (CMT2K) 10.1007/s10048-008-0166-9

Mitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitis 10.1016/j.diabet.2008.06.001

Hereditary amyloid neuropathy by transthyretin Val107 mutation in a patient of African origin 10.1111/j.1529-8027.2008.00185.x

Leukodystrophies: clinical and therapeutic aspects 10.1016/s0072-9752(07)01265-1

Neuropathie démyélinisante au cours d’un traitement par anti-TNF alpha et revue de la littérature 10.1016/s0035-3787(07)78408-4

An autopsy case of acute multiple sclerosis (Marburg's type) during pregnancy 10.1016/j.clineuro.2008.01.011

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes 10.1093/brain/awm298

Phenotype associated with APP duplication in five families 10.1093/brain/awl237

Neurofilament high molecular weight–green fluorescent protein fusion is normally expressed in neurons and transported in axons: A neuronal marker to investigate the biology of neurofilaments 10.1016/j.neuroscience.2005.08.077

Syndrome de Garcin révélant un lymphome malin non hodgkinien 10.1016/s0035-3787(04)71080-2

Stable Tubule Only Polypeptides (STOP) Proteins Co-Aggregate with Spheroid Neurofilaments in Amyotrophic Lateral Sclerosis 10.1093/jnen/62.12.1211

TRANSSPHENOIDAL SURGERY IN THE ELDERLY 10.1034/j.1600-0579.2003.00229.x

Two clinicopathological cases of a dominantly inherited, adult onset orthochromatic leucodystrophy 10.1136/jnnp.74.5.671

Cytoskeleton abnormalities in axonopathies of unknown aetiology: correlations with morphometry 10.1016/s0022-510x(02)00025-4

A chasing dead-end case report: a fatal lead intoxication following an attempted homicide 10.1007/s11419-019-00519-5

Differences in clinical features between small fiber and sensitive large fiber neuropathies in Sjögren's syndrome 10.1016/j.ejim.2020.05.004

The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer’s disease 10.1186/s40478-020-00954-1

STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain 10.1111/nan.12646

Joel Eyer

Eyer Joel

ORCID: 0000-0001-6301-7465

Neurofilament cytoskeleton disruption does not modify accumulation of trophic factor mRNA 10.1002/jnr.1100

Axonal neurofilaments are nonessential elements of toxicant-induced reductions in fast axonal transport: Video-enhanced differential interference microscopy in peripheral nervous system axons 10.1006/taap.1999.8780

Motor coordination and spatial orientation are affected by neurofilament maldistribution: correlations with regional brain activity of cytochrome oxidase 10.1007/s002210050732

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NAFTIDROFURYL, A PUTATIVE ACTIVATOR OF NEURON SURVIVAL, STIMULATES THE EXPRESSION OF NEUROFILAMENT HEAVY SUBUNIT IN CULTIVATED SPINAL-CORD NEURONS FROM CHICKEN 10.1006/bbrc.1994.1477

NEUROFILAMENT-DEFICIENT AXONS AND PERIKARYAL AGGREGATES IN VIABLE TRANSGENIC MICE EXPRESSING A NEUROFILAMENT-BETA-GALACTOSIDASE FUSION PROTEIN 10.1016/0896-6273(94)90280-1

AGE-DEPENDENT CHANGES IN THE ULTRASTRUCTURE AND IN THE MOLECULAR COMPOSITION OF RAT-BRAIN MICROTUBULES 10.1111/j.1471-4159.1992.tb08355.x

Effect of a single dose of beta,beta'-iminodipropionitrile in vivo on the properties of neurofilaments in vitro: comparison with the effect of iminodipropionitrile added directly to neurofilaments in vitro. 10.1111/j.1471-4159.1989.tb07254.x

Bull sperm 19S dynein polymerizes brain tubulin into microtubules. 10.1016/0006-291X(87)91098-9

The Carbocyanine Dye DiD Labels In Vitro and In Vivo Neural Stem Cells of the Subventricular Zone as Well as Myelinated Structures Following In Vivo Injection in the Lateral Ventricle 10.1002/jnr.23694

Investigating the Structural Variability and Binding Modes of the Glioma Targeting NFL-TBS.40-63 Peptide on Tubulin 10.1021/acs.biochem5b00146

NEUROFILAMENTS AND NFL-TBS.40-63 PEPTIDE PENETRATE OLIGODENDROCYTES THROUGH CLATHRIN-DEPENDENT ENDOCYTOSIS TO PROMOTE THEIR GROWTH AND SURVIVAL IN VITRO 10.1016/j.neuroscience.2015.04.003

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040

Neurofilament-Tubulin Binding Site Peptide NFL-TBS.40-63 Increases the Differentiation of Oligodendrocytes In Vitro and Partially Prevents Them From Lysophosphatidyl Choline Toxiciy 10.1002/jnr.23308

The NFL-TBS.40-63 Anti-Glioblastoma Peptide Disrupts Microtubule and Mitochondrial Networks in the T98G Glioma Cell Line 10.1371/journal.pone.0098473

AXONAL REGENERATION IS COMPROMISED IN NFH-LACZ TRANSGENIC MICE BUT NOT IN NFH-GFP MICE 10.1016/j.neuroscience.2012.10.011

Axoskeletal proteins prevent oligodendrocyte from toxic injury by upregulating survival, proliferation, and differentiation in vitro 10.1016/j.neuint.2012.12.012

Review on intermediate filaments of the nervous system and their pathological alterations 10.1007/s00418-013-1101-1

The effect of functionalizing lipid nanocapsules with NFL-TBS.40-63 peptide on their uptake by glioblastoma cells 10.1016/j.biomaterials.2013.01.068

The NFL-TBS.40-63 anti-glioblastoma peptide enters selectively in glioma cells by endocytosis 10.1016/j.ijpharm.2013.04.004

A Tubulin Binding Peptide Targets Glioma Cells Disrupting Their Microtubules, Blocking Migration, and Inducing Apoptosis 10.1038/mt.2012.45

Axon cytoskeleton proteins specifically modulate oligodendrocyte growth and differentiation in vitro 10.1016/j.neuint.2011.10.011

Brain tumour targeting strategies via coated ferrociphenol lipid nanocapsules 10.1016/j.ejpb.2012.04.012

Structure-Function Analysis of the Glioma Targeting NFL-TBS.40-63 Peptide Corresponding to the Tubulin-Binding Site on the Light Neurofilament Subunit 10.1371/journal.pone.0049436

The vimentin-tubulin binding site peptide (Vim-TBS.58-81) crosses the plasma membrane and enters the nuclei of human glioma cells 10.1016/j.ijpharm.2011.04.067

N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination 10.1242/dev.058677

Axonal Plasticity Elicits Long-Term Changes in Oligodendroglia and Myelinated Fibers 10.1002/glia.20897

Microtubule-independent regulation of neurofilament interactions in vitro by neurofilament-bound ATPase activities 10.1016/j.bbrc.2009.04.045

Neurofilament cross-bridging competes with kinesin-dependent association of neurofilaments with microtubules 10.1242/jcs.051318

Neurofilaments Bind Tubulin and Modulate Its Polymerization 10.1523/JNEUROSCI.1924-09.2009

Neuronal intermediate filaments and neurodegenerative disorders 10.1016/j.brainresbull.2009.06.004

Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration 10.1007/s12035-008-8033-0

Axonal neurofilaments control multiple fiber properties but do not influence structure or spacing of nodes of Ranvier 10.1523/JNEUROSCI.1224-07.2007

alpha-Internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS 10.1523/JNEUROSCI.2580-06.2006

Neurofilament high molecular weight-green fluorescent protein fusion is normally expressed in neurons and transported in axons: A neuronal marker to investigate the biology of neurofilaments 10.1016/j.neuroscience.2005.08.077

Accelerated diabetic neuropathy in axons without neurofilaments 10.1093/brain/awh251

The amount of neurofilaments aggregated in the cell body is controlled by their increased sensitivity to trypsin-like proteases 10.1242/jcs.00940

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Estelle Marion

Marion Estelle

ORCID: 0000-0003-4917-9665

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FVB/N Mice Spontaneously Heal Ulcerative Lesions Induced by Mycobacterium ulcerans and Switch M. ulcerans into a Low Mycolactone Producer 10.4049/jimmunol.1502194

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A Field Study in Benin to Investigate the Role of Mosquitoes and Other Flying Insects in the Ecology of Mycobacterium ulcerans 10.1371/journal.pntd.0003941

Buruli Ulcer in South Western Nigeria: A Retrospective Cohort Study of Patients Treated in Benin 10.1371/journal.pntd.0003443

Development of a Dry-Reagent-Based qPCR to Facilitate the Diagnosis of Mycobacterium ulcerans Infection in Endemic Countries 10.1371/journal.pntd.0003606

Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography 10.1371/journal.pntd.0004247

A case of guilt by association: Water bug bite incriminated in M. ulcerans infection 10.1016/j.ijmyco.2014.01.004

Buruli Ulcer Disease in Republic of the Congo 10.3201/eid2006.131498

Establishment of Quantitative PCR (qPCR) and Culture Laboratory Facilities in a Field Hospital in Benin: 1-Year Results 10.1128/jcm.02131-14

Findings in Patients From Benin With Osteomyelitis and Polymerase Chain Reaction-Confirmed Mycobacterium ulcerans Infection 10.1093/cid/ciu584

First Detection of Mycobacterium ulcerans DNA in Environmental Samples from South America 10.1371/journal.pntd.0002660

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040

Buruli ulcer: a dynamic transversal research model performed through the international network of Pasteur Institutes 10.1051/medsci/20132910021

Parasitic genotypes appear to differ in leishmaniasis patients compared with asymptomatic related carriers 10.1016/j.ijpara.2012.12.008

Regulation of Mycolactone, the Mycobacterium ulcerans Toxin, Depends on Nutrient Source 10.1371/journal.pntd.0002502

Photodegradation of the Mycobacterium ulcerans Toxin, Mycolactones: Considerations for Handling and Storage 10.1371/journal.pone.0033600

Geographic Expansion of Buruli Ulcer Disease, Cameroon 10.3201/eid1703091859

Buruli Ulcer, Central African Republic 10.3201/eid1604.090195

Seasonal and Regional Dynamics of M. ulcerans Transmission in Environmental Context: Deciphering the Role of Water Bugs as Hosts and Vectors 10.1371/journal.pntd.0000731

Use of Fine-Needle Aspiration for Diagnosis of Mycobacterium ulcerans Infection 10.1128/jcm.00558-10

Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer 10.1371/journal.pntd.0000553

Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology 10.1371/journal.ppat.1009107

High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice 10.7717/peerj.9659

Genome-wide association study of Buruli ulcer in rural Benin highlights role of two LncRNAs and the autophagy pathway 10.1038/s42003-020-0920-6

Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial 10.1016/s0140-6736(20)30047-7

Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection 10.1126/sciadv.aax7781

Stable and Local Reservoirs of Mycobacterium ulcerans Inferred from the Nonrandom Distribution of Bacterial Genotypes, Benin 10.3201/eid2603.190573

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model 10.1128/iai.00753-19

Senegal, a new potential endemic country for Buruli ulcer? 10.1016/j.ijid.2019.09.020

Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative survey 10.1016/s2542-5196(19)30110-x

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378

Microdeletion on chromosome 8p23.1 in a familial form of severe Buruli ulcer 10.1371/journal.pntd.0006429

The potent effect of mycolactone on lipid membranes 10.1371/journal.ppat.1006814

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227

Mouse model of colonization of the digestive tract withAcinetobacter baumanniiand subsequent pneumonia 10.2217/fmb-2016-0203

Draft Genome Sequence of Mycobacterium ulcerans S4018 Isolated from a Patient with an Active Buruli Ulcer in Benin, Africa 10.1128/genomea.00248-17

An Optimized Method for Extracting Bacterial RNA from Mouse Skin Tissue Colonized by Mycobacterium ulcerans 10.3389/fmicb.2017.00512

Multiple introductions and recent spread of the emerging human pathogen Mycobacterium ulcerans across Africa 10.1093/gbe/evx003

Vincent Paillé

Paillé Vincent

ORCID: 0000-0003-0424-0821

Perinatal Western Diet Consumption Leads to Profound Plasticity and GABAergic Phenotype Changes within Hypothalamus and Reward Pathway from Birth to Sexual Maturity in Rat. 10.3389/fendo.2017.00216

Developmental control of spike-timing-dependent plasticity by tonic GABAergic signaling in striatum. 10.1016/j.neuropharm.2017.04.012

[The sensory and nutritional experience of parents guide offsprings' feeding behavior]. 10.1051/medsci/20163201014

Endocannabinoids mediate bidirectional striatal spike-timing-dependent plasticity. 10.1113/jp270324

Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways. 10.1016/j.cell.2014.04.040

GABAergic circuits control spike-timing-dependent plasticity. 10.1523/jneurosci.5796-12.2013

Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia. 10.1093/brain/awq342

Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition. 10.1523/jneurosci.2149-10.2010

Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity. 10.1113/jphysiol.2010.188466

Kinetics of microglial activation and degeneration of dopamine-containing neurons in a rat model of Parkinson disease induced by 6-hydroxydopamine. 10.1097/nen.0b013e3181b767b4

Epilepsy-induced abnormal striatal plasticity in Bassoon mutant mice. 10.1111/j.1460-9568.2009.06733.x

Asymmetric spike-timing dependent plasticity of striatal nitric oxide-synthase interneurons. 10.1016/j.neuroscience.2009.03.015

l-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation. 10.1016/j.nbd.2007.10.001

Rat model of Parkinson's disease with bilateral motor abnormalities, reversible with levodopa, and dyskinesias. 10.1002/mds.21308

Role of nigral lesion in the genesis of dyskinesias in a rat model of Parkinson's disease. 10.1097/00001756-200403010-00035

Lipopolysaccharide and TNFalpha regulate the expression of GDNF, neurturin and their receptors. 10.1097/00001756-200308060-00026

Protein expression in submandibular glands of young rats is modified by a high-fat/high-sugar maternal diet 10.1016/j.archoralbio.2018.08.021

Maternal Protein Restriction in Rats Alters the Expression of Genes Involved in Mitochondrial Metabolism and Epitranscriptomics in Fetal Hypothalamus 10.3390/nu12051464

Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner 10.3390/ijms21155428

Guillaume Sandoz

Sandoz Guillaume

ORCID: 0000-0003-1251-0852

https://www.sandozlab.com/

Microfluidic separation of magnetic nanoparticles on an ordered array of magnetized micropillars. 10.1103/physreve.93.062604

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Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. 10.1073/pnas.1407160111

Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways. 10.1016/j.cell.2014.04.040

Baclofen and other GABAB receptor agents are allosteric modulators of the CXCL12 chemokine receptor CXCR4. 10.1523/jneurosci.6070-11.2013

Optogenetic techniques for the study of native potassium channels. 10.3389/fnmol.2013.00006

[Optical remote control of native ion channels]. 10.1051/medsci/20122811011

Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. 10.1016/j.neuron.2012.04.026

Molecular regulations governing TREK and TRAAK channel functions. 10.4161/chan.5.5.16469

Optical probing of a dynamic membrane interaction that regulates the TREK1 channel. 10.1073/pnas.1015788108

A modern ionotropic glutamate receptor with a K(+) selectivity signature sequence. 10.1038/ncomms1231

Potassium channel silencing by constitutive endocytosis and intracellular sequestration. 10.1074/jbc.m109.078535

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue. 10.1073/pnas.0906267106

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Protein complex analysis of native brain potassium channels by proteomics. 10.1007/978-1-59745-526-8_9

Does sumoylation control K2P1/TWIK1 background K+ channels? 10.1016/j.cell.2007.06.012

AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels. 10.1038/sj.emboj.7601437

Cavbeta-subunit displacement is a key step to induce the reluctant state of P/Q calcium channels by direct G protein regulation. 10.1073/pnas.0306804101

Repositioning of charged I-II loop amino acid residues within the electric field by beta subunit as a novel working hypothesis for the control of fast P/Q calcium channel inactivation. 10.1111/j.1460-9568.2004.03216.x

Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels. 10.1046/j.1432-1033.2003.03743.x

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The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner. 10.1074/jbc.m106231200

Evolution of maurotoxin conformation and blocking efficacy towards Shaker B channels during the course of folding and oxidation in vitro. 10.1042/0264-6021:3610409

Distinct properties and differential beta subunit regulation of two C-terminal isoforms of the P/Q-type Ca(2+)-channel alpha(1A) subunit. 10.1046/j.0953-816x.2001.01728.x

Parameters affecting in vitro oxidation/folding of maurotoxin, a four-disulphide-bridged scorpion toxin. 10.1042/0264-6021:3580681

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Maurotoxin versus Pi1/HsTx1 scorpion toxins. Toward new insights in the understanding of their distinct disulfide bridge patterns. 10.1074/jbc.m006810200

Synthesis, 1H NMR structure, and activity of a three-disulfide-bridged maurotoxin analog designed to restore the consensus motif of scorpion toxins. 10.1074/jbc.275.18.13605

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Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. 10.1016/j.neuron.2018.11.039

TREK for High-Speed and High-Frequency Conduction through the Axon. 10.1016/j.neuron.2019.11.015

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KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies. 10.1016/j.cell.2020.11.047

Marsollier Laurent

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ORCID: 0000-0001-5497-5995

High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice. 10.7717/peerj.9659

Genome-wide association study of Buruli ulcer in rural Benin highlights role of two LncRNAs and the autophagy pathway. 10.1038/s42003-020-0920-6

Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model. 10.1128/iai.00753-19

Senegal, a new potential endemic country for Buruli ulcer? 10.1016/j.ijid.2019.09.020

Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls. 10.3390/toxins11090516

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters. 10.3389/fphar.2019.00378

Microdeletion on chromosome 8p23.1 in a familial form of severe Buruli ulcer. 10.1371/journal.pntd.0006429

The potent effect of mycolactone on lipid membranes. 10.1371/journal.ppat.1006814

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. 10.15252/embr.201744371

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. 10.3390/toxins9070227

Mouse model of colonization of the digestive tract with Acinetobacter baumannii and subsequent pneumonia. 10.2217/fmb-2016-0203

Ecology and Feeding Habits Drive Infection of Water Bugs with Mycobacterium ulcerans. 10.1007/s10393-017-1228-y

Draft Genome Sequence of Mycobacterium ulcerans S4018 Isolated from a Patient with an Active Buruli Ulcer in Benin, Africa. 10.1128/genomea.00248-17

An Optimized Method for Extracting Bacterial RNA from Mouse Skin Tissue Colonized by Mycobacterium ulcerans. 10.3389/fmicb.2017.00512

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