Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women
Seron, K. Corset, L. Vasseur, F. Boutin, P. Gomez-Ambrosi, J. Salvador, J. Fruhbeck, G. Froguel, P.
Karin Seron
Seron Karin
ORCID: 0000-0002-9667-133X
Identification of class II ADP-ribosylation factors as cellular factors required for hepatitis C virus replication 10.1111/cmi.12572
Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5
Characterization of Hepatitis C Virus Interaction with Heparan Sulfate Proteoglycans 10.1128/jvi.03647-14
Claudin-6 and Occludin Natural Variants Found in a Patient Highly Exposed but Not Infected with Hepatitis C Virus (HCV) Do Not Confer HCV Resistance In Vitro 10.1371/journal.pone.0142539
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438
Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15
Identification of Conserved Residues in Hepatitis C Virus Envelope Glycoprotein E2 That Modulate Virus Dependence on CD81 and SRB1 Entry Factors 10.1128/jvi.01402-14
Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022
Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors 10.1016/j.bmcl.2014.07.051
(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry 10.1002/hep.24803
Hepatitis C Virus and Natural Compounds: A New Antiviral Approach? 10.3390/v4102197
Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway 10.1074/jbc.M111.224857
Identification of a dominant endoplasmic reticulum-retention signal in yellow fever virus pre-membrane protein 10.1099/vir.0.015339-0
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity 10.1073/pnas.0706671104
ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity 10.2337/diabetes.55.02.06.db05-0971
Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women 10.1016/j.bbrc.2006.07.068
Genetic study of the CD36 gene In a French diabetic population 10.1016/s1262-3636(07)70143-x
GAD2 on chromosome 10p12 is a candidate gene for human obesity 10.1371/journal.pbio.0000068
Molecular cloning, functional complementation in Saccharomyces cerevisiae and enzymatic properties of phosphatidylinositol synthase from the protozoan parasite Toxoplasma gondii 10.1046/j.1432-1327.2000.01749.x
Disruption of six novel genes from the left arm of chromosome XV of Saccharomyces cerevisiae and basic phenotypic analysis of the generated mutants 10.1002/(sici)1097-0061(19990115)15:1<73::aid-yea341>3.0.co;2-q
Efficient transcription obtained by a new procedure of the tRNA-like structure of turnip yellow mosaic virus by a template-dependent and specific viral RNA polymerase 10.1016/s0166-0934(96)02166-0
Efficient transcription obtained by a new procedure of the tRNA-like structure of turnip yellow mosaic virus by a template-dependent and specific viral RNA polymerase (vol 64, pg 181, 1997) 10.1016/s0166-0934(96)02249-5
Expression of the 69K movement protein of turnip yellow mosaic virus in insect cells 10.1006/viro.1996.0246
Gene expression from viral RNA genomes 10.1007/bf00039391
Vascular movement of plant viruses 10.1094/mpmi-9-0435
Entry and release of hepatitis C virus in polarized human hepatocytes. 10.1128/jvi.00478-17
An ecological approach to discover new bioactive extracts and products: the case of extremophile plants. 10.1111/jphp.12728
Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus. 10.1128/jvi.00404-16
Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin. 10.1016/j.antiviral.2016.07.011
Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus 10.1101/325126
Viral hepatitis in the Peruvian Amazon: Ethnomedical context and phytomedical resource. 10.1016/j.jep.2020.112735
Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus. 10.1021/acsami.9b15032
Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication. 10.1128/jvi.02009-18
Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. 10.1371/journal.pone.0198226
Correction for Belouzard et al., "Entry and Release of Hepatitis C Virus in Polarized Human Hepatocytes". 10.1128/jvi.00309-18
Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488
A yeast t-SNARE involved in endocytosis. 10.1091/mbc.9.10.2873
Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483
Javier Gomez-Ambrosi
Gomez-Ambrosi Javier
ORCID: 0000-0001-5601-1604
Increased Cardiometabolic Risk Factors and Inflammation in Adipose Tissue in Obese Subjects Classified as Metabolically Healthy 10.2337/dc14-0937
Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice 10.1038/ijo.2014.166
FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet- or surgically-induced weight loss 10.1016/j.clnu.2016.04.027
Clinical usefulness of abdominal bioimpedance (ViScan) in the determination of visceral fat and its application in the diagnosis and management of obesity and its comorbidities 10.1016/j.clnu.2017.01.010
Gastric Plication Improves Glycemia Partly by Restoring the Altered Expression of Aquaglyceroporins in Adipose Tissue and the Liver in Obese Rats. 10.1007/s11695-016-2532-2
Acylated and desacyl ghrelin are associated with hepatic lipogenesis, β-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats. 10.1038/srep39942
Increased Obesity-Associated Circulating Levels of the Extracellular Matrix Proteins Osteopontin, Chitinase-3 Like-1 and Tenascin C Are Associated with Colon Cancer. 10.1371/journal.pone.0162189
[Body weight- independent variations in HDL-cholesterol following gastric bypass]. 10.4321/s1137-6627/2016000100004
Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes. 10.1038/ijo.2016.66
Circulating ANGPTL8/Betatrophin Concentrations Are Increased After Surgically Induced Weight Loss, but Not After Diet-Induced Weight Loss. 10.1007/s11695-015-2026-7
[Colour scale percent body fat by CUN-BAE adiposity estimator]. 10.1016/j.aprim.2015.09.003
Changes in Body Composition in Anorexia Nervosa: Predictors of Recovery and Treatment Outcome. 10.1371/journal.pone.0143012
Physical activity in anorexia nervosa: How relevant is it to therapy response? 10.1016/j.eurpsy.2015.09.008
Sleeve Gastrectomy Decreases Body Weight, Whole-Body Adiposity, and Blood Pressure Even in Aged Diet-Induced Obese Rats. 10.1007/s11695-015-1919-9
Sleeve Gastrectomy Reduces Body Weight and Improves Metabolic Profile also in Obesity-Prone Rats. 10.1007/s11695-015-1915-0
Sleeve Gastrectomy Reduces Hepatic Steatosis by Improving the Coordinated Regulation of Aquaglyceroporins in Adipose Tissue and Liver in Obese Rats. 10.1007/s11695-015-1612-z
Cardiometabolic Profile Related to Body Adiposity Identifies Patients Eligible for Bariatric Surgery More Accurately than BMI. 10.1007/s11695-014-1566-6
Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism. 10.1016/j.mce.2015.08.014
Smell-taste dysfunctions in extreme weight/eating conditions: analysis of hormonal and psychological interactions. 10.1007/s12020-015-0684-9
Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women. 10.1210/jc.2015-1595
Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice. 10.1038/srep12067
Modulation of Higher-Order Olfaction Components on Executive Functions in Humans. 10.1371/journal.pone.0130319
Peripheral mononuclear blood cells contribute to the obesity-associated inflammatory state independently of glycemic status: involvement of the novel proinflammatory adipokines chemerin, chitinase-3-like protein 1, lipocalin-2 and osteopontin. 10.1007/s12263-015-0460-8
Does body adiposity better predict obesity-associated cardiometabolic risk than body mass index? 10.1016/j.jacc.2014.09.092
Expression of syntaxin 8 in visceral adipose tissue is increased in obese patients with type 2 diabetes and related to markers of insulin resistance and inflammation. 10.1016/j.arcmed.2014.12.003
Effect of sleeve gastrectomy on osteopontin circulating levels and expression in adipose tissue and liver in rats. 10.1007/s11695-014-1240-z
Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns. 10.1016/j.bbadis.2014.09.004
Expression of S6K1 in human visceral adipose tissue is upregulated in obesity and related to insulin resistance and inflammation. 10.1007/s00592-014-0632-9
Moderate-vigorous physical activity across body mass index in females: moderating effect of endocannabinoids and temperament. 10.1371/journal.pone.0104534
Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes. 10.1210/jc.2014-1568
Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice. 10.1371/journal.pone.0098398
Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammation. 10.1210/jc.2014-1191
Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients. 10.1038/ijo.2014.76
Mechanisms linking excess adiposity and carcinogenesis promotion. 10.3389/fendo.2014.00065
Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. 10.1155/2014/857270
Comparative effects of gastric bypass and sleeve gastrectomy on plasma osteopontin concentrations in humans. 10.1007/s00464-014-3490-1
Insulin resistance modulates iron-related proteins in adipose tissue. 10.2337/dc13-1602
Relationship between eating styles and temperament in an Anorexia Nervosa, Healthy Control, and Morbid Obesity female sample. 10.1016/j.appet.2014.01.012
Adipose tissue immunity and cancer. 10.3389/fphys.2013.00275
Letter by Gomez-Ambrosi et al regarding article, "clinical assessment and management of adult obesity". 10.1161/circulationaha.112.001400
Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. 10.1371/journal.pone.0066387
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Targeting the circulating microRNA signature of obesity. 10.1373/clinchem.2012.195776
Liver, but not adipose tissue PEDF gene expression is associated with insulin resistance. 10.1038/ijo.2012.223
Role of extracellular matrix remodelling in adipose tissue pathophysiology: relevance in the development of obesity. 10.14670/hh-27.1515
Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity. 10.1007/s00394-012-0464-8
Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. 10.1186/1741-7015-10-108
Short-term effects of sleeve gastrectomy and caloric restriction on blood pressure in diet-induced obese rats. 10.1007/s11695-012-0702-4
Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity. 10.1371/journal.pone.0043382
The ghrelin O-acyltransferase-ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes. 10.1007/s00125-012-2671-5
Increased tenascin C and Toll-like receptor 4 levels in visceral adipose tissue as a link between inflammation and extracellular matrix remodeling in obesity. 10.1210/jc.2012-1670
Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: evidence of the role of Med1 in energy balance. 10.1152/physiolgenomics.00039.2012
Short- and long-term changes in gastric morphology and histopathology following sleeve gastrectomy in diet-induced obese rats. 10.1007/s11695-012-0606-3
Identification of liver proteins altered by type 2 diabetes mellitus in obese subjects. 10.1111/j.1478-3231.2012.02765.x
Sleeve gastrectomy reduces blood pressure in obese (fa/fa) Zucker rats. 10.1007/s11695-011-0562-3
Leptin reduces the expression and increases the phosphorylation of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4 in muscle of ob/ob mice. 10.1371/journal.pone.0029389
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Clinical usefulness of a new equation for estimating body fat. 10.2337/dc11-1334
The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity. 10.2337/db11-0649
Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients. 10.1016/j.soard.2011.11.001
Sleeve gastrectomy induces weight loss in diet-induced obese rats even if high-fat feeding is continued. 10.1007/s11695-010-0277-x
Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. 10.1038/ijo.2011.100
Expression profile in omental and subcutaneous adipose tissue from lean and obese subjects. Repression of lipolytic and lipogenic genes. 10.1007/s11695-010-0246-4
Body adiposity and type 2 diabetes: increased risk with a high body fat percentage even having a normal BMI. 10.1038/oby.2011.36
Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade. 10.1210/jc.2010-1408
Up-regulation of the novel proinflammatory adipokines lipocalin-2, chitinase-3 like-1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer. 10.1016/j.jnutbio.2010.04.015
Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass. 10.1210/jc.2010-0994
Leptin administration downregulates the increased expression levels of genes related to oxidative stress and inflammation in the skeletal muscle of ob/ob mice. 10.1155/2010/784343
Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function. 10.1371/journal.pone.0010962
Leptin inhibits the proliferation of vascular smooth muscle cells induced by angiotensin II through nitric oxide-dependent mechanisms. 10.1155/2010/105489
Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes. 10.1186/1743-7075-7-20
Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss. 10.1007/s00198-010-1174-9
Association of plasma acylated ghrelin with blood pressure and left ventricular mass in patients with metabolic syndrome. 10.1097/hjh.0b013e328334327c
Association of increased visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity. 10.1016/j.numecd.2009.09.008
IPO8 and FBXL10: new reference genes for gene expression studies in human adipose tissue. 10.1038/oby.2009.374
Complement factor H is expressed in adipose tissue in association with insulin resistance. 10.2337/db09-0700
Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice. 10.1371/journal.pone.0006808
Involvement of serum vascular endothelial growth factor family members in the development of obesity in mice and humans. 10.1016/j.jnutbio.2009.05.004
The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects. 10.1038/oby.2009.202
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans. 10.1007/s00109-009-0486-8
Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. 10.1038/ijo.2009.40
Adipokines in the treatment of diabetes mellitus and obesity. 10.1517/14656560802618811
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The bone-adipose axis in obesity and weight loss. 10.1007/s11695-008-9548-1
Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver. 10.1007/s11695-008-9453-7
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Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. 10.1007/s11695-008-9424-z
Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. 10.1111/j.1365-2265.2007.03021.x
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Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. 10.1016/j.bbrc.2006.07.068
Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways. 10.1016/j.tips.2006.05.002
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Adipokine dysregulation and adipose tissue inflammation in human obesity 10.1111/eci.12997
Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation 10.3390/nu11020454
GLP-1 Limits Adipocyte Inflammation and Its Low Circulating Pre-Operative Concentrations Predict Worse Type 2 Diabetes Remission after Bariatric Surgery in Obese Patients 10.3390/jcm8040479
Circulating Concentrations of GDF11 are Positively Associated with TSH Levels in Humans 10.3390/jcm8060878
Role of ghrelin isoforms in the mitigation of hepatic inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress after bariatric surgery in rats 10.1038/s41366-019-0420-2
Increase of the Adiponectin/Leptin Ratio in Patients with Obesity and Type 2 Diabetes after Roux-en-Y Gastric Bypass 10.3390/nu11092069
Functional Relationship between Leptin and Nitric Oxide in Metabolism 10.3390/nu11092129
NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling 10.1038/s41423-019-0296-z
Aquaporin-11 Contributes to TGF-β1-induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation 10.3390/cells9061403
Resting Energy Expenditure Is Not Altered in Children and Adolescents with Obesity. Effect of Age and Gender and Association with Serum Leptin Levels 10.3390/nu13041216
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Adipokines in the treatment of diabetes mellitus and obesity http://dx.doi.org/10.1517/14656560802618811
Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control http://dx.doi.org/10.4161/cc.10.10.15672
Circulating omentin concentration increases after weight loss http://dx.doi.org/10.1186/1743-7075-7-27
Disruption of the Leptin-Insulin Relationship in Obese Men 24 Hours after Laparoscopic Adjustable Silicone Gastric Banding http://dx.doi.org/10.1381/096089202321088174
Evidence for the Involvement of Resistin in Inflammation and Cardiovascular Disease http://dx.doi.org/10.2174/157339905774574392
Fasting Plasma Ghrelin Concentrations 6 Months after Gastric Bypass are not Determined by Weight Loss or Changes in Insulinemia http://dx.doi.org/10.1381/0960892042386904
Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats http://dx.doi.org/10.1016/j.lfs.2008.07.022
Influence of Waist Circumference on the Metabolic Risk Associated with Impaired Fasting Glucose: Effect of Weight Loss after Gastric Bypass http://dx.doi.org/10.1007/s11695-007-9101-7
Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors http://dx.doi.org/10.1016/s0009-9120(02)00320-x
Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide http://dx.doi.org/10.1016/s0898-6568(01)00211-x
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Perspectives in the therapeutic use of leptin http://dx.doi.org/10.1517/14656566.2.10.1615
RIP140 Gene and Protein Expression Levels are Downregulated in Visceral Adipose Tissue in Human Morbid Obesity http://dx.doi.org/10.1007/s11695-009-9834-6
Resistin and RELM-α gene expression in white adipose tissue of lactating mice http://dx.doi.org/10.1016/s0006-291x(02)00846-x
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Unlocking the molecular basis of obesity http://dx.doi.org/10.2217/17460875.2.6.577
Caloric Restriction Prevents Metabolic Dysfunction and the Changes in Hypothalamic Neuropeptides Associated with Obesity Independently of Dietary Fat Content in Rats 10.3390/nu13072128
Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling 10.3390/ijms22168485
FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes 10.1038/s41423-021-00762-0
Philippe Froguel
Froguel Philippe
ORCID: 0000-0003-2972-0784
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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk 10.1038/ncomms10495
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Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci 10.1038/ng.3437
What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity? 10.1371/journal.pone.0143373
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Genetic association analyses highlight biological pathways underlying mitral valve prolapse 10.1038/ng.3383
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Genetic Determinants of Leucocyte Telomere Length in Children: a Neglected and Challenging Field 10.1111/ppe.12173
Biological interpretation of genome-wide association studies using predicted gene functions 10.1038/ncomms6890
RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human beta Cells 10.1016/j.celrep.2014.11.010
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Defining the role of common variation in the genomic and biological architecture of adult human height 10.1038/ng.3097
Identification of Two Novel Loss-of-Function SIM1 Mutations in Two Overweight Children with Developmental Delay 10.1002/oby.20886
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Fine-scale human genetic structure in Western France 10.1038/ejhg.2014.175
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Common Genetic Variants and Risk of Brain Injury After Preterm Birth 10.1542/peds.2013-3011
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Quality control and conduct of genome-wide association meta-analyses 10.1038/nprot.2014.071
Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice 10.1371/journal.pone.0092684
Multi-ethnic fine-mapping of 14 central adiposity loci 10.1093/hmg/ddu183
A Central Role for GRB10 in Regulation of Islet Function in Man 10.1371/journal.pgen.1004235
Low copy number of the salivary amylase gene predisposes to obesity 10.1038/ng.2939
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CDKN2B expression and subcutaneous adipose tissue expandability: Possible influence of the 9p21 atherosclerosis locus 10.1016/j.bbrc.2014.03.075
Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions 10.1155/2014/873679
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Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes 10.1007/s12015-014-9503-6
Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4 alpha at the protein level 10.1007/s00125-013-3154-z
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility 10.1038/ng.2897
Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. 10.1155/2013/139239
Direct Estimates of Natural Selection in Iberia Indicate Calcium Absorption Was Not the Only Driver of Lactase Persistence in Europe 10.1093/molbev/msu049
Novel LEPR Mutations in Obese Pakistani Children Identified by PCR-Based Enrichment and Next Generation Sequencing 10.1002/oby.20667
Leveraging Cross- Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms 10.1016/j.cell.2013.10.058
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity 10.2337/db13-0949
Coffee and tea consumption, genotype- based CYP1A2 and NAT2 activity and colorectal cancer risk- Results from the EPIC cohort study 10.1002/ijc.28655
Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates 10.1371/journal.pgen.1003919
Peroxisome Proliferator-activated Receptor gamma Regulates Genes Involved in Insulin/Insulin-like Growth Factor Signaling and Lipid Metabolism during Adipogenesis through Functionally Distinct Enhancer Classes 10.1074/jbc.M113.526996
The SH2B1 obesity locus and abnormal glucose homeostasis: Lack of evidence for association from a meta-analysis in individuals of European ancestry 10.1016/j.numecd.2013.05.001
Highly Sensitive Diagnosis of 43 Monogenic Forms of Diabetes or Obesity Through One-Step PCR-Based Enrichment in Combination With Next-Generation Sequencing 10.2337/dc13-0698
Meal Frequencies Modify the Effect of Common Genetic Variants on Body Mass Index in Adolescents of the Northern Finland Birth Cohort 1986 10.1371/journal.pone.0073802
GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm 10.1371/journal.pgen.1003657
Genome-wide association study identifies three novel loci for type 2 diabetes 10.1093/hmg/ddt399
Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts 10.1007/s00125-013-3021-y
Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck 10.1186/gb-2013-14-7-309
Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics 10.1016/j.ajhg.2013.06.011
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death 10.1038/ng.2712
Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications 10.1038/ng.2700
Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes 10.1186/1742-4682-10-45
Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore? 10.1371/journal.pone.0067650
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features 10.1172/JCI68035
Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects 10.1007/s12020-013-0009-9
Evidence for tuning adipocytes ICER levels for obesity care. 10.4161/adip.20000
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits 10.1371/journal.pgen.1003500
Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations 10.1007/s00109-013-1027-z
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders 10.1038/ng.2610
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture 10.1038/ng.2606
Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci 10.1101/gr.155127.113
Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family 10.1016/j.diabet.2013.02.007
Rare Genomic Structural Variants in Complex Disease: Lessons from the Replication of Associations with Obesity 10.1371/journal.pone.0058048
From obesity genetics to the future of personalized obesity therapy 10.1038/nrendo.2013.57
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity,Weight loss and resting metabolic rate 10.1016/j.bbrc.2013.03.031
Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity 10.1002/oby.20443
Integration of clinical data with a genome-scale metabolic model of the human adipocyte 10.1038/msb.2013.5
What Is the Contribution of Two Genetic Variants Regulating VEGF Levels to Type 2 Diabetes Risk and to Microvascular Complications? 10.1371/journal.pone.0055921
Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels 10.1007/s00125-013-2875-3
Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts 10.1371/journal.pmed.1001383
Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children 10.1186/1471-2350-14-21
Blood Microbiota Dysbiosis Is Associated with the Onset of Cardiovascular Events in a Large General Population: The DESIR Study 10.1371/journal.pone.0054461
Improved Protocol For Laser Microdissection Of Human Pancreatic Islets From Surgical Specimens 10.3791/50231
Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India 10.2337/db12-1077
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations 10.1038/ng.2500
Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men 10.1210/jc.2012-2764
Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes 10.1007/s00125-012-2794-8
Seventy-five genetic loci influencing the human red blood cell 10.1038/nature11677
Estimation of Newborn Risk for Child or Adolescent Obesity: Lessons from Longitudinal Birth Cohorts 10.1371/journal.pone.0049919
Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21 10.2337/db12-0406/-/DC1
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism 10.1038/ng.2477
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes 10.1007/s00125-012-2756-1
Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population 10.1038/ijo.2012.175
A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site 10.1182/blood-2012-01-401893
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A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans 10.2337/db12-0454
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways 10.1038/ng.2385
TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals 10.1007/s00125-012-2660-8
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes 10.1038/ng.2383
GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes 10.1007/s00125-012-2645-7
Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms 10.1371/journal.pone.0040351
Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers 10.1093/nar/gks595
Whole-Exome Sequencing and High Throughput Genotyping Identified KCNJ11 as the Thirteenth MODY Gene 10.1371/journal.pone.0037423
Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits 10.2337/db11-1515
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases 10.1371/journal.pgen.1002741
The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size 10.1371/journal.pone.0038216
Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity 10.1371/journal.pone.0035810
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity 10.1093/hmg/dds187
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone 10.1152/ajpregu.00373.2011
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance 10.1038/ng.2274
Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women 10.1371/journal.pgen.1002695
The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis 10.1016/j.beem.2011.12.001
Circadian Gene Variants and Susceptibility to Type 2 Diabetes: A Pilot Study 10.1371/journal.pone.0032670
A genome-wide association meta-analysis identifies new childhood obesity loci 10.1038/ng.2247
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals 10.1371/journal.pgen.1002607
High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families 10.1016/j.ymgme.2012.03.001
European genetic variants associated with type 2 diabetes in North African Arabs 10.1016/j.diabet.2012.02.003
Loss-of-Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population 10.1038/oby.2012.77
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations 10.1093/hmg/dds113
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels 10.2337/db11-0973
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis 10.1038/ng.2232
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron 10.1038/ng.2218
A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels 10.1371/journal.pone.0032327
Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations 10.1371/journal.pgen.1002490
Multicohort Genomewide Association Study Reveals a New Signal of Protection Against HIV-1 Acquisition 10.1093/infdis/jis028
Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study 10.1111/j.1365-2796.2012.02532.x
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma 10.1038/ng.1085
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human 10.1038/nature10798
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes 10.1038/ng.1053
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans 10.1371/journal.pone.0029202
Parent-Offspring Correlations in Pedometer-Assessed Physical Activity 10.1371/journal.pone.0029195
Clinical and Metabolic Features of Adult-Onset Diabetes Caused by ABCC8 Mutations 10.2337/dc11-1469
Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk 10.2337/db11-0728
Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity 10.2337/db11-0305
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians 10.1038/ng.1019
New gene functions in megakaryopoiesis and platelet formation 10.1038/nature10659
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children 10.1371/journal.pmed.1001116
Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion 10.1074/jbc.M111.254995
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma 10.1038/ng.970
Low Water Intake and Risk for New-Onset Hyperglycemia 10.2337/dc11-0652
Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene 10.1371/journal.pone.0025470
The Lin28/let-7 Axis Regulates Glucose Metabolism 10.1016/j.cell.2011.08.033
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus 10.1038/nature10406
Effects of Genetic Susceptibility for Type 2 Diabetes on the Evolution of Glucose Homeostasis Traits Before and After Diabetes Diagnosis Data From the DESIR Study 10.2337/db10-1442
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes 10.2337/db11-0415
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci 10.1038/ng.921
ITIH-5 Expression in Human Adipose Tissue Is Increased in Obesity 10.1038/oby.2011.268
Characterization of the human SLC30A8 promoter and intronic enhancer 10.1530/JME-11-0055
A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes 10.1007/s00125-011-2261-y
Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes 10.1186/1471-2350-12-99
Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity 10.1038/oby.2011.200
Systems medicine and integrated care to combat chronic noncommunicable diseases 10.1186/gm259
Common Variants in FTO, MC4R, TMEM18, PRL, AIF1 and PCSK1 Show Evidence of Association With Adult Obesity in the Greek Population 10.1038/oby.2011.177
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study 10.1007/s00125-011-2182-9
Number of children and change in markers of metabolic health over 9-years in men and women. Data from the DESIR study 10.1016/j.diabet.2011.04.006
Accurate Single-Nucleotide Polymorphism Allele Assignment in Trisomic or Duplicated Regions by Using a Single Base-Extension Assay with MALDI-TOF Mass Spectrometry 10.1373/clinchem.2010.159558
Disruption of a Novel Kruppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus 10.1074/jbc.M110.215822
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes 10.1038/ng.833
famCNV: copy number variant association for quantitative traits in families 10.1093/bioinformatics/btr264
Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations 10.1038/ijo.2011.86
Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study 10.1038/ijo.2011.91
Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children 10.2337/db10-1575
Chromosome 19p13.3 Deletion in a Patient With Macrocephaly, Obesity, Mental Retardation, and Behavior Problems 10.1002/ajmg.a.33986
Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway 10.1074/jbc.M111.224857
Dairy Consumption and the Incidence of Hyperglycemia and the Metabolic Syndrome Results from a French prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) 10.2337/dc10-1772
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits 10.1371/journal.pgen.1001324
Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue 10.1038/ijo.2011.22
Metabolic health, obesity and 9-year incidence of peripheral arterial disease: The DESIR study 10.1016/j.atherosclerosis.2011.02.032
Investigation of the HIN200 Locus in UK SLE Families Identifies Novel Copy Number Variants 10.1111/j.1469-1809.2011.00641.x
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease 10.1038/ng.782
Bio-Repository of DNA in stroke (BRAINS): A study protocol 10.1186/1471-2350-12-34
Childhood Obesity Is Associated with Shorter Leukocyte Telomere Length 10.1210/jc.2010-2924
TCF7L2 splice variants have distinct effects on beta-cell turnover and function 10.1093/hmg/ddr072
Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals 10.3945/ajcn.110.000828
Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations 10.1111/j.1399-5448.2010.00719.x
Influence of blood glucose on heart rate and cardiac autonomic function. The DESIR study 10.1111/j.1464-5491.2010.03222.x
Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine 10.1111/j.1749-6632.2010.05880.x
Screening Low-Frequency SNPS From Genome-Wide Association Study Reveals a New Risk Allele for Progression to AIDS 10.1097/QAI.0b013e318204982b
Molecular Diagnosis of Neonatal Diabetes Mellitus Using Next-Generation Sequencing of the Whole Exome 10.1371/journal.pone.0013630
Lack of Association of CD36 SNPs With Early Onset Obesity: A Meta-Analysis in 9,973 European Subjects 10.1038/oby.2010.226
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 10.1038/ng.686
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution 10.1038/ng.685
Mean and yearly changes in blood pressure with age in the metabolic syndrome: the DESIR study 10.1038/hr.2010.180
Common Variants at 10 Genomic Loci Influence Hemoglobin A(1C) Levels via Glycemic and Nonglycemic Pathways 10.2337/db10-0502
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B 10.1038/ng.660
Evaluation of A2BP1 as an Obesity Gene 10.2337/db09-1604
The emerging genetics of type 2 diabetes 10.1016/j.molmed.2010.06.004
Multiple-Cohort Genetic Association Study Reveals CXCR6 as a New Chemokine Receptor Involved in Long-Term Nonprogression to AIDS 10.1086/655782
Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies 10.2337/dc10.1150
Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the G6PC2 Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels 10.2337/db10-0389
Expression of the selenoprotein S (SELS) gene m subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors 10.1016/j.metabol.2010.05.011
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis 10.1038/ng.609
Monogenic forms of diabetes mellitus: an update. 10.1016/S1575-0922(09)73513-2
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Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups 10.1371/journal.pgen.1000916
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Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians 10.2337/db08-1805
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The common P446L polymorphism in GCAR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population 10.2337/db07-1807
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Common variants near MC4R are associated with fat mass, weight and risk of obesity 10.1038/ng.140
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Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids 10.1007/s00125-008-0973-4
A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults 10.2337/db07-1547
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population 10.1093/hmg/ddn070
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Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations 10.1007/s00125-007-0887-6
Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids 10.1007/s00125-007-0857-z
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Lack of association between the Pro(12)Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population 10.1007/s00592-007-0013-8
A single-nucleotide polymorphism in the p110 beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents 10.1210/jc.2007-1822
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ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study 10.1007/s00125-007-0787-9
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Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity 10.1186/1471-2350-8-44
TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population 10.1186/1471-2350-8-37
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity 10.1038/ng2046
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Variation in FTO contributes to childhood obesity and severe adult obesity 10.1038/ng2048
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Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes 10.1210/jc.2006-2657
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A genome-wide association study identifies novel risk loci for type 2 diabetes 10.1038/nature05616
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No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects 10.1007/s00125-006-0505-z
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TCF7L2 variation predicts hyperglycentia incidence in a French general population - The Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study 10.2337/db06-0692
Epistasis between type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans 10.1111/j.1469-1809.2006.00289.x
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Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes 10.2337/db05-1369
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Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1 10.1007/s00439-005-0036-6
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes 10.1038/ng1604
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Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes 10.1007/s00125-005-1806-3
Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity 10.1007/s00125-005-1729-z
Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population 10.1186/1471-2156-6-19
Implication of the Pro 12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population 10.1186/1471-2350-6-11
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The EIF2AK3 gene region and type 1 diabetes in subjects from South India 10.1038/sj.gene.6364139
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A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. 10.1002/humu.9256
Understanding the rising incidence of type 2 diabetes in adolescence 10.1136/adc.2003.028548
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Dissection of an inverted X(p21.3q27.1) chromosome associated with mental retardation 10.1159/000074167
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PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population 10.1007/s00125-003-1170-0
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects 10.1038/nature01705
Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease 10.1038/sj.mp.4001344
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Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations 10.1093/hmg/ddg016
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis 10.1074/jbc.M209033200
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase 10.1038/nm788
Rare variants identified in the HNF-4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes 10.1007/s00125-002-0913-7
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Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children 10.1067/mpd.2001.116284
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ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers 10.1002/lipd.12087
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CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability 10.1016/j.molmet.2018.05.005
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Epigenome-wide association study of adiposity and future risk of obesity-related diseases 10.1038/s41366-018-0064-7
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes 10.2337/dc18-1032
Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation 10.1016/j.scr.2018.02.017
Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes 10.1002/oby.22064
High Prevalence of Rare Monogenic Forms of Obesity in Obese Guadeloupean Afro-Caribbean Children 10.1210/jc.2017-01956
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes 10.2337/db17-1539
Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose 10.3389/fgene.2018.00210
Loss-of-function mutations in ADCY3 cause monogenic severe obesity 10.1038/s41588-017-0023-6
MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue 10.1016/j.jacl.2018.07.009
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes 10.1007/s00125-017-4500-3
The unique clinical spectrum of maturity onset diabetes of the young type 3 10.1016/j.diabres.2017.10.024
Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling 10.1126/scisignal.aan6622
Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease 10.3389/fendo.2017.00304
Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? 10.1007/s11892-017-0957-1
Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect 10.1186/s13148-020-00858-w
Clustering for a better prediction of type 2 diabetes mellitus 10.1038/s41574-021-00475-4