Paperbase

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi

Spadafora, C. Repetto, Y. Torres, C. Pino, L. Robello, C. Morello, A. Gamarro, F. Castanys, S.

Molecular and biochemical parasitology, 2002

https://doi.org/10.1016/S0166-6851(02)00156-1

CARLOS ROBELLO

ROBELLO CARLOS

ORCID: 0000-0001-6985-6171

The Tritryps Comparative Repeatome: Insights on Repetitive Element Evolution in Trypanosomatid Pathogens 10.1093/gbe/evz017

The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole 10.1371/journal.pone.0212593

Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro 10.1038/s41598-019-41697-x

Nanopore Sequencing Significantly Improves Genome Assembly of the Protozoan Parasite Trypanosoma cruzi 10.1093/gbe/evz129

Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System 10.1016/B978-0-12-801078-5.00014-5

Deep sequencing discovery of causal mtDNA mutations in a patient with unspecific neurological disease 10.1016/j.mito.2018.09.004

Transcriptomic analysis reveals metabolic switches and surface remodeling as key processes for stage transition in trypanosoma cruzi 10.7717/peerj.3017

Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection 10.1111/imm.12979

Cloning, characterization and subcellular localization of a Trypanosoma cruzi argonaute protein defining a new subfamily distinctive of trypanosomatids 10.1016/j.gene.2010.06.012

Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical 10.1073/pnas.1821487116

Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole 10.1007/s00436-008-1264-1

Whole genome sequencing of the monomorphic pathogen Mycobacterium bovis reveals local differentiation of cattle clinical isolates 10.1186/s12864-017-4249-6

Kinetoplast adaptations in American strains from Trypanosoma vivax 10.1016/j.mrfmmm.2015.01.008

Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptic culture conditions 10.1038/sj.leu.2403169

Insights on gene expression response of a characterized resistant genotype of Solanum commersonii Dun. against Ralstonia solanacearum 10.1007/s10658-013-0210-y

Trypanosoma cruzi: Molecular cloning of a gene coding for a putative vacuolar protein 10.1006/expr.1999.4485

TcI isolates of Trypanosoma cruzi exploit the antioxidant network for enhanced intracellular survival in macrophages and virulence in mice 10.1128/IAI.00193-16

Molecular characterization and interactome analysis of Trypanosoma cruzi tryparedoxin II 10.1016/j.jprot.2015.03.001

Molecular characterization and interactome analysis of Trypanosoma cruzi Tryparedoxin 1 10.1016/j.jprot.2011.04.006

Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers 10.1002/ijc.29910

Genome sequence of the native apiculate wine yeast Hanseniaspora vineae T02/19AF 10.1128/genomeA.00530-14

Trypanosoma cruzi chemical proteomics using immobilized benznidazole 10.1016/j.exppara.2014.03.013

Molecular analysis of isoniazid-resistant Mycobacterium tuberculosis isolates in Uruguay 10.5588/ijtld.11.0559

Heme-oxygenase-1 expression contributes to the immunoregulation induced by Fasciola hepatica and promotes infection 10.3389/fimmu.2017.00883

Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi 10.1016/j.freeradbiomed.2018.10.436

Tryparedoxin peroxidases from Trypanosoma cruzi: High efficiency in the catalytic elimination of hydrogen peroxide and peroxynitrite 10.1016/j.abb.2010.12.014

Transcriptome studies in trypanosoma cruzi using RNA-seq 10.1007/978-1-4939-9148-8_3

Rapidly progressing tuberculosis outbreak in a very low risk group 10.1183/09031936.00150413

Proteomic analysis of metacyclic trypomastigotes undergoing Trypanosoma cruzi metacyclogenesis 10.1002/jms.1267

Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi 10.1099/mgen.0.000177

Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi 10.1186/s13071-018-2988-0

Complete genome sequence of Mycobacterium tuberculosis strain MtURU-001, isolated from a rapidly progressing outbreak in Uruguay 10.1128/genomeA.e01220-13

Profiling of small RNA cargo of extracellular vesicles shed by Trypanosoma cruzi reveals a specific extracellular signature 10.1016/j.molbiopara.2015.03.003

The first case report of trypanosomiasis caused by Trypanosoma evansi in Uruguay 10.1016/j.vprsr.2017.11.002

Release of the cytosolic tryparedoxin peroxidase into the incubation medium and a different profile of cytosolic and mitochondrial peroxiredoxin expression in H2O2-treated Trypanosoma cruzi tissue culture-derived trypomastigotes 10.1016/j.exppara.2012.12.007

Peroxiredoxins from Trypanosoma cruzi: Virulence factors and drug targets for treatment of Chagas disease? 10.1016/j.gene.2007.10.014

Autochthonous outbreak and expansion of canine visceral Leishmaniasis, Uruguay 10.3201/eid2303.160377

Early Trypanosoma cruzi infection triggers mTORC1-mediated respiration increase and mitochondrial biogenesis in human primary cardiomyocytes 10.3389/fmicb.2018.01889

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool 10.1128/AAC.05046-14

Sialyl-Tn antigen expression and O-linked GalNAc-Thr synthesis by Trypanosoma cruzi 10.1016/j.bbrc.2003.11.060

Gene expression profiling in the injured spinal cord of Trachemys scripta elegans: An amniote with self-repair capabilities 10.3389/fnmol.2017.00017

Redox metabolism in Trypanosoma cruzi: Functional characterization of tryparedoxins revisited 10.1016/j.freeradbiomed.2013.04.036

Identification of Mycobacterium tuberculosis complex by polymerase chain reaction of Exact Tandem Repeat-D fragment from mycobacterial cultures 10.1016/j.ijmyco.2012.07.002

Gene expression analysis identifies new candidate genes associated with the development of black skin spots in Corriedale sheep 10.1007/s13353-011-0066-9

Whole-genome sequencing of an isoniazid-resistant clinical isolate of Mycobacterium tuberculosis strain MtURU-002 from Uruguay 10.1128/genomeA.00655-14

Transcriptome sequencing reveals wide expression reprogramming of basal and unknown genes in Leptospira biflexa biofilms 10.1128/mSphere.00042-16

Whole-genome sequences of Mycobacterium bovis strain MbURU-001, isolated from fresh bovine infected samples 10.1128/genomeA.01237-15

Redox metabolism in Trypanosoma cruzi. Biochemical characterization of dithiol glutaredoxin dependent cellular pathways 10.1016/j.biochi.2014.07.027

Somatic mutations can lead to a loss of superantigenic and polyreactive binding 10.1002/eji.200424936

GALNT11 as a new molecular marker in chronic lymphocytic leukemia 10.1016/j.gene.2013.09.052

Cloning, localization and differential expression of the Trypanosoma cruzi TcOGNT-2 glycosyl transferase 10.1016/j.gene.2012.02.018

Evolutionary relationships in Trypanosoma cruzi: Molecular phylogenetics supports the existence of a new major lineage of strains 10.1016/S0378-1119(00)00074-3

A new member of YER057c family in Trypanosoma cruzi is adjacent to an ABC-transporter 10.1016/S0378-1119(98)00439-9

Extracellular vesicles shed by Trypanosoma cruzi are linked to small RNA pathways, life cycle regulation, and susceptibility to infection of mammalian cells 10.1007/s00436-013-3655-1

Imidazolium compounds are active against all stages of Trypanosoma cruzi 10.1016/j.ijantimicag.2013.10.019

3697G>A in MT-ND1 is a causative mutation in mitochondrial disease 10.1016/j.mito.2016.03.006

Correction: The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole (PLoS ONE (2019) 14:2 (e0212593) DOI: 10.1371/journal.pone.0212593) 10.1371/journal.pone.0215199

Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols 10.1074/jbc.M404317200

Mucin-type O-glycosylation in Mesocestoides vogae (syn. corti) 10.1016/j.ijpara.2007.07.015

Cloning, expression, and characterization of a dithiol glutaredoxin from trypanosoma cruzi 10.1089/ars.2009.2907

Proteome analysis of the causative agent of Chagas disease: Trypanosoma cruzi 10.1016/j.ijpara.2004.05.002

MUC5B silencing reduces chemo-resistance of MCF-7 breast tumor cells and impairs maturation of dendritic cells 10.3892/ijo.2016.3434

A population of tRNA-derived small RNAs is actively produced in Trypanosoma cruzi and recruited to specific cytoplasmic granules 10.1016/j.molbiopara.2010.02.003

Genome-wide diversity and differentiation in New World populations of the human malaria parasite Plasmodium vivax 10.1371/journal.pntd.0005824

International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patients 10.1371/journal.pntd.0000931

Revisiting the human polypeptide GalNAc-T1 and T13 paralogs 10.1093/glycob/cww111

Deltamethrin Resistance Mechanisms in Aedes aegypti Populations from Three French Overseas Territories Worldwide 10.1371/journal.pntd.0004226

Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients 10.1186/s13071-015-0632-9

Role of Trypanosoma cruzi peroxiredoxins in mitochondrial bioenergetics 10.1007/s10863-011-9365-4

Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation 10.1242/jcs.089375

Crystal structure of the tryparedoxin peroxidase from the human parasite Trypanosoma cruzi 10.1016/j.jsb.2004.12.005

Old Yellow Enzyme from Trypanosoma cruzi exhibits in vivo Prostaglandin F2α synthase activity and has a key role in parasite infection and drug susceptibility 10.3389/fimmu.2018.00456

Detection of a soluble antigen defined by monoclonal antibody 83D4 in serous effusions associated with breast carcinoma 10.1002/1097-0142(19920401)69:7<1745::AID-CNCR2820690716>3.0.CO;2-H

Research priorities for neglected infectious diseases in Latin America and the Caribbean Region 10.1371/journal.pntd.0000780

Trypanosoma cruzi: Molecular characterization of an RNA binding protein differentially expressed in the parasite life cycle 10.1016/j.exppara.2007.03.010

Early trypanosoma cruzi infection reprograms human epithelial cells 10.1155/2014/439501

Immunomodulatory activity of an anti-HSV-1 synthetic stigmastane analog 10.1016/j.bmc.2012.10.054

Oligomerization dynamics and functionality of Trypanosoma cruzi cytosolic tryparedoxin peroxidase as peroxidase and molecular chaperone 10.1016/j.bbagen.2019.06.013

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi 10.1016/S0166-6851(02)00156-1

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi 10.1016/S0166-6851(97)00207-7

Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation 10.1038/leu.2014.158

Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of trypanosoma cruzi iron-superoxide dismutases (fe-sods) a and b : Disparate susceptibilities due to the repair of tyr35 radical by cys83 in fe-sodb through intramolecular electron transfer 10.1074/jbc.M113.545590

Transcriptome analysis of the bloodstream stage from the parasite Trypanosoma vivax 10.1186/1471-2164-14-149

Modulation of gene expression during early stages of reconnection of the turtle spinal cord 10.1111/j.1471-4159.2012.07750.x

First case of Mycobacterium heckeshornense cavitary lung disease in the Latin America and Caribbean region 10.1016/j.nmni.2015.12.003

Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis 10.1038/sj.leu.2405022

Selenosemicarbazones as potent cruzipain inhibitors and their antiparasitic properties against Trypanosoma cruzi 10.1039/c2md00283c

New approach towards the synthesis of selenosemicarbazones, useful compounds for Chagas' disease 10.1038/srep04703

Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus 10.1042/BJ20031877

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics 10.1371/journal.pntd.0002844

Tryparedoxin peroxidases and superoxide dismutases expression as well as ROS release are related to Trypanosoma cruzi epimastigotes growth phases 10.1016/j.abb.2012.02.020

A Nature-Inspired Design Yields a New Class of Steroids Against Trypanosomatids 10.3390/molecules24203800

Notch receptor expression in Trypanosoma cruzi ‐infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis 10.1002/cbin.11308

Leishmania infantum isolates exhibit high infectivity and reduced susceptibility to amphotericin B 10.1039/D0MD00073F

Author Correction: Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro 10.1038/s41598-020-69582-y

Trypanothione Metabolism as Drug Target for Trypanosomatids 10.2174/1381612826666201211115329

Maxicircle architecture and evolutionary insights into Trypanosoma cruzi complex 10.1101/2021.05.11.443566

Maxicircle architecture and evolutionary insights into Trypanosoma cruzi complex 10.1371/journal.pntd.0009719

Francisco Gamarro

Gamarro Francisco

ORCID: 0000-0003-1347-3440

Functional role of highly conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase. 10.1042/bcj20170749

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. 10.1371/journal.pntd.0006052

Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols. 10.1042/bcj20170685

ABCI3 Is a New Mitochondrial ABC Transporter from Leishmania major Involved in Susceptibility to Antimonials and Infectivity. 10.1128/aac.01115-17

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei. 10.1016/j.bmcl.2017.07.032

Leishmania LABCG1 and LABCG2 transporters are involved in virulence and oxidative stress: functional linkage with autophagy. 10.1186/s13071-017-2198-1

Arylthiosemicarbazones as antileishmanial agents. 10.1016/j.ejmech.2016.07.014

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum. 10.1016/j.ijpddr.2016.04.003

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes. 10.1371/journal.pone.0154101

Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents. 10.1016/j.ejmech.2016.04.047

The LABCG2 Transporter from the Protozoan Parasite Leishmania Is Involved in Antimony Resistance. 10.1128/aac.02813-15

Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance. 10.1021/acs.jmedchem.5b01429

The Oral Antimalarial Drug Tafenoquine Shows Activity against Trypanosoma brucei. 10.1128/aac.00879-15

Fitness of Leishmania donovani parasites resistant to drug combinations. 10.1371/journal.pntd.0003704

Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-β-agarofuran Sesquiterpenes from Celastrus vulcanicola. 10.1021/np500903a

Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations. 10.1128/aac.04231-14

Mechanisms of action of substituted β-amino alkanols on Leishmania donovani. 10.1128/aac.04003-14

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease. 10.1177/1087057114555846

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes. 10.1016/j.ejmech.2014.10.040

4-amino bis-pyridinium derivatives as novel antileishmanial agents. 10.1128/aac.02481-13

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit. 10.1042/bj20131318

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening. 10.1093/jac/dkt407

A new ABC half-transporter in Leishmania major is involved in resistance to antimony. 10.1128/aac.00211-13

LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania. 10.1371/journal.pntd.0002179

Leishmania donovani develops resistance to drug combinations. 10.1371/journal.pntd.0001974

Oxazolo[3,2-a]pyridine. A new structural scaffold for the reversal of multi-drug resistance in Leishmania. 10.1016/j.bmcl.2012.07.100

Terpenoids from Maytenus species and assessment of their reversal activity against a multidrug-resistant Leishmania tropica line. 10.1002/cbdv.201000356

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania. 10.1093/jac/dkr345

Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-β-agarofuran sesquiterpenes. 10.1016/j.ejmech.2011.07.048

The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. 10.1128/aac.00520-11

Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania. 10.1128/aac.00065-11

A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania. 10.1111/j.1365-2958.2010.07531.x

Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major. 10.1128/aac.01545-10

Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine. 10.1128/aac.01592-10

Non-reducing trisaccharide fatty acid monoesters: novel detergents in membrane biochemistry. 10.1016/j.bbamem.2010.11.031

Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis. 10.1128/aac.00790-10

Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine. 10.1128/aac.00985-10

Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion. 10.1371/journal.pone.0012443

Leishmanicidal and reversal multidrug resistance constituents from Aeonium lindleyi. 10.1055/s-0030-1250144

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells. 10.1016/j.bcp.2010.05.017

Novel dihydro-beta-agarofuran sesquiterpenes as potent modulators of human P-glycoprotein dependent multidrug resistance. 10.1039/b915678j

Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug. 10.1128/aac.01694-08

Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania. 10.1021/jm800403b

Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. 10.1128/aac.00964-08

Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement. 10.1128/aac.00587-08

All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiae. 10.1091/mbc.e08-05-0467

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. 10.1073/pnas.0704384105

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania. 10.1016/j.bmc.2007.10.071

The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells. 10.1016/j.bbamem.2007.10.017

Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance. 10.1021/jm070290v

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo. 10.1016/j.ijantimicag.2007.05.007

A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids. 10.1111/j.1365-2958.2007.05653.x

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux. 10.1128/aac.00423-06

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites. 10.1074/jbc.m605214200

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use. 10.1016/j.drup.2006.04.001

Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein. 10.1016/j.bbamem.2005.12.006

Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis. 10.1021/jm058003f

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. 10.1158/0008-5472.can-04-1817

The overexpression of an intracellular ABCA-like transporter alters phospholipid trafficking in Leishmania. 10.1016/j.bbrc.2005.02.176

Functional expression of a multidrug P-glycoprotein transporter of Leishmania. 10.1016/j.bbrc.2005.02.009

Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania. 10.2174/1381612054864920

Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi. 10.1111/j.1365-2958.2004.04304.x

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance. 10.1158/0008-5472.can-04-1005

SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter. 10.1021/jm0309699

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine). 10.1016/s0924-8579(03)00125-0

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance. 10.1074/jbc.m308352200

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug. 10.1128/aac.47.8.2397-2403.2003

The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity. 10.1016/s0005-2736(03)00131-7

Rapid transport of phospholipids across the plasma membrane of Leishmania infantum. 10.1016/s0006-291x(03)00947-1

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance. 10.1007/s000180300044

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi. 10.1016/s0166-6851(02)00156-1

Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a search for reversal agents. 10.2174/1389450023347588

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters. 10.1007/s00018-002-8424-8

Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis. 10.1021/jm010970c

ABC transporters in the protozoan parasite Leishmania. 10.1007/s10123-001-0031-2

Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator. 10.1128/aac.45.9.2468-2474.2001

Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity. 10.1021/bi002453m

High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin. 10.1128/aac.45.2.439-446.2001

Evolutionary relationships in Trypanosoma cruzi: molecular phylogenetics supports the existence of a new major lineage of strains. 10.1016/s0378-1119(00)00074-3

Trypanosoma cruzi: molecular cloning of a gene coding for a putative vacuolar protein. 10.1006/expr.1999.4485

Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon. 10.1016/s0167-4781(99)00195-5

New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line. 10.1021/jm991066b

Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin. 10.1021/bi982455v

Involvement of thiol metabolism in resistance to glucantime in Leishmania tropica. 10.1016/s0006-2952(98)00129-4

A new member of YER057c family in Trypanosoma cruzi is adjacent to an ABC-transporter. 10.1016/s0378-1119(98)00439-9

Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line. 10.1016/s0006-2952(97)00385-7

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi. 10.1016/s0166-6851(97)00207-7

An amino acid channel activated by hypotonically induced swelling of Leishmania major promastigotes. 10.1042/bj3190691

Molecular characterization of a P-glycoprotein-related tcpgp2 gene in Trypanosoma cruzi. 10.1016/0166-6851(95)02519-7

Addendum to "Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme" [Mol. Biochem. Parasitol. 72 (1995) 11-22]. 10.1016/0166-6851(95)02532-4

Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme. 10.1016/0166-6851(95)00059-a

Trypanosoma cruzi: sequence of the ATP-binding site of a P-glycoprotein gene. 10.1006/expr.1994.1061

P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica. 10.1016/0006-2952(94)90067-1

The different behavior of diphtheria toxin, modeccin and ricin in HeLa cells infected with Trypanosoma cruzi. 10.1111/j.1550-7408.1994.tb01503.x

Increased P-type ATPase activity in Leishmania tropica resistant to methotrexate. 10.1006/bbrc.1994.1307

Possible coexistence of two independent mechanisms contributing to anthracycline resistance in leukaemia P388 cells. 10.1016/0959-8049(93)90050-p

Trypanosoma cruzi: calcium ion movement during internalization in host HeLa cells. 10.1016/0020-7519(90)90126-8

Purification of a glycoprotein excreted by Trypanosoma cruzi to increase the permeability of the host-cell membrane. 10.1016/0006-291x(90)90871-j

New antiparasitic agents. III. Comparison between trypanocidal activities of some acridine derivatives against Trypanosoma cruzi in vitro. 10.1159/000238559

Antiamebic activity of new acridinic derivatives against Naegleria and Acanthamoeba species in vitro. 10.1159/000238471

Inhibition of lysosomal fusion by Trypanosoma cruzi in peritoneal macrophages. 10.1016/0020-7519(86)90031-7

Effect of interferon on the infectivity of Trypanosoma cruzi in cultured HeLa cells. 10.1016/0020-7519(85)90082-7

[Effect of proteolytic enzymes on the penetration of Trypanosoma cruzi in peritoneal macrophages of mice]. 10.1051/parasite/1985604383

Effect of poly-L-lysine and neuraminidase on the infectivity of Trypanosoma cruzi in cultured HeLa cells. 10.1007/bf00928345

Isolation and purification of amastigotes of Trypanosoma cruzi from cultured vero cells. 10.1007/bf00932914

Some factors affecting the in vitro invasion of HeLa cells by Trypanosoma cruzi. 10.1016/0020-7519(84)90076-6

Purification of metacyclic forms of Trypanosoma cruzi by Percoll discontinuous gradient centrifugation. 10.1007/bf00926684

Santiago Castanys

Castanys Santiago

ORCID: 0000-0002-3460-844X

RESISTANCE TO REINFECTION OF HELA-CELLS PARASITIZED BY TRYPANOSOMA-CRUZI 10.2307/3281775

SOME FACTORS AFFECTING THE INVITRO INVASION OF HELA-CELLS BY TRYPANOSOMA-CRUZI 10.1016/0020-7519(84)90076-6

PURIFICATION OF METACYCLIC FORMS OF TRYPANOSOMA-CRUZI BY PERCOLL DISCONTINUOUS GRADIENT CENTRIFUGATION 10.1007/BF00926684

EFFECT OF TREATMENT WITH PROTEOLYTIC-ENZYMES ON THE INTERIORIZATION OF TRYPANOSOMA-CRUZI IN MICE PERITONEAL-MACROPHAGES 10.1051/PARASITE/1985604383

EFFECT OF POLY-L-LYSINE AND NEURAMINIDASE ON THE INFECTIVITY OF TRYPANOSOMA-CRUZI IN CULTURED HELA-CELLS 10.1007/BF00928345

EFFECT OF INTERFERON ON THE INFECTIVITY OF TRYPANOSOMA-CRUZI IN CULTURED HELA-CELLS 10.1016/0020-7519(85)90082-7

ISOLATION AND PURIFICATION OF AMASTIGOTES OF TRYPANOSOMA-CRUZI FROM CULTURED VERO CELLS 10.1007/BF00932914

INHIBITION OF LYSOSOMAL FUSION BY TRYPANOSOMA-CRUZI IN PERITONEAL-MACROPHAGES 10.1016/0020-7519(86)90031-7

ANTITRYPANOSOMAL ACTION OF CIS-DIAMMINEDICHLOROPLATINUM (II) ANALOGS 10.2307/3282078

ACTIVITY AGAINST TRYPANOSOMA-CRUZI OF NEW ANALOGS OF NIFURTIMOX 10.1002/ARDP.19873200205

ANTIAMEBIC ACTIVITY OF NEW ACRIDINIC DERIVATIVES AGAINST NAEGLERIA AND ACANTHAMOEBA SPECIES INVITRO 10.1159/000238471

INHIBITORY EFFECT OF NEW PYRIMIDINE-BASES ON TRYPANOSOMA-CRUZI 10.1002/ARDP.19893221202

NEW ANTIPARASITIC AGENTS .3. COMPARISON BETWEEN TRYPANOCIDAL ACTIVITIES OF SOME ACRIDINE-DERIVATIVES AGAINST TRYPANOSOMA-CRUZI INVITRO 10.1159/000238559

TRYPANOSOMA-CRUZI - CALCIUM-ION MOVEMENT DURING INTERNALIZATION IN HOST HELA-CELLS 10.1016/0020-7519(90)90126-8

PURIFICATION OF A GLYCOPROTEIN EXCRETED BY TRYPANOSOMA-CRUZI TO INCREASE THE PERMEABILITY OF THE HOST-CELL MEMBRANE 10.1016/0006-291X(90)90871-J

PYRIDINIUM AZOLATE BETAINES AND THEIR DERIVATIVES - A NEW CLASS OF ANTIPROTOZOAL AGENTS 10.1016/0223-5234(90)90114-I

POSSIBLE COEXISTENCE OF 2 INDEPENDENT MECHANISMS CONTRIBUTING TO ANTHRACYCLINE RESISTANCE IN LEUKEMIA-P388 CELLS 10.1016/0959-8049(93)90050-P

TRYPANOSOMA-CRUZI - SEQUENCE OF THE ATP-BINDING SITE OF A P-GLYCOPROTEIN GENE 10.1006/EXPR.1994.1061

P-GLYCOPROTEIN OVEREXPRESSION IN METHOTREXATE-RESISTANT LEISHMANIA-TROPICA 10.1016/0006-2952(94)90067-1

A PROTEIN SECRETED BY TRYPANOSOMA-CRUZI CAPABLE OF INDUCING THE ENTRY OF INERT PARTICLES INTO HELA-CELLS 10.1016/0020-7519(95)00037-3

INCREASED P-TYPE ATPASE ACTIVITY IN LEISHMANIA-TROPICA RESISTANT TO METHOTREXATE 10.1006/BBRC.1994.1307

Molecular characterization of a P-glycoprotein-related tcpgp2 gene in Trypanosoma cruzi 10.1016/0166-6851(95)02519-7

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi 10.1016/S0166-6851(97)00207-7

Altered drug membrane permeability in a multidrug resistant Leishmania tropica line 10.1016/S0006-2952(97)00385-7

A new member of YER057c family in Trypanosoma cruzi is adjacent to an ABC-transporter 10.1016/S0378-1119(98)00439-9

Involvement of thiol metabolism in resistance to glucantime in Leishmania tropica 10.1016/S0006-2952(98)00129-4

Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon 10.1016/S0167-4781(99)00195-5

Evolutionary relationships in Trypanosoma cruzi: molecular phylogenetics supports the existence of a new major lineage of strains 10.1016/S0378-1119(00)00074-3

New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line 10.1021/JM991066B

Different catalytic activities of hexokinase and phosphofructokinase in wild type and Glucantime-resistant Leishmania promastigotes appears not causatively related to resistance 10.1016/S0932-4739(99)80012-1

Trypanosoma cruzi: Molecular cloning of a gene coding for a putative vacuolar protein 10.1006/EXPR.1999.4485

Alkyl-lysophospholipid resistance in multi drug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator 10.1128/AAC.45.9.2468-2474.2001

Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis 10.1021/JM010970C

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi 10.1016/S0166-6851(02)00156-1

Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: A search for reversal agents 10.2174/1389450023347588

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters 10.1007/S00018-002-8424-8

Functional cloning of the miltefosine transporter - A novel P-type phospholipid translocase from Leishmania involved in drug resistance 10.1074/JBC.M308352200

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine) 10.1016/S0924-8579(03)00125-0

Sitamaquine Sensitivity in Leishmania Species Is Not Mediated by Drug Accumulation in Acidocalcisomes 10.1128/AAC.00964-08

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug 10.1128/AAC.47.8.2397-2403.2003

Rapid transport of phospholipids across the plasma membrane of Leishmania infantum 10.1016/S0006-291X(03)00947-1

The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity 10.1016/S0005-2736(03)00131-7

Dihidro-beta-agarofuran sesquiterpenes: A new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania 10.2174/1381612054864920

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance 10.1007/S000180300044

Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi 10.1111/J.1365-2958.2004.04304.X

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance 10.1158/0008-5472.CAN-04-1005

Flavonoid structure-activity studies identify 6-prenyichrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2 10.1158/0008-5472.CAN-04-1817

The overexpression of an intracellular ABCA-like transporter alters phospholipid trafficking in Leishmania 10.1016/J.BBRC.2005.02.176

Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis 10.1021/JM058003F

Functional expression of a multidrug P-glycoprotein transporter of Leishmania 10.1016/J.BBRC.2005.02.009

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites 10.1074/JBC.M605214200

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to miltefosine by inhibiting drug efflux 10.1128/AAC.00423-06

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use 10.1016/J.DRUP.2006.04.001

Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein 10.1016/J.BBAMEM.2005.12.006

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania 10.1093/JAC/DKR345

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo 10.1016/J.IJANTIMICAG.2007.05.007

Bis-pyranobenzoquinones as a New Family of Reversal Agents of the Multidrug Resistance Phenotype Mediated by P-Glycoprotein in Mammalian Cells and the Protozoan Parasite Leishmania 10.1021/JM800403B

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania 10.1016/J.BMC.2007.10.071

Increased Glycolytic ATP Synthesis Is Associated with Tafenoquine Resistance in Leishmania major 10.1128/AAC.01545-10

The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells 10.1016/J.BBAMEM.2007.10.017

Novel dihydro-beta-agarofuran sesquiterpenes as potent modulators of human P-glycoprotein dependent multidrug resistance 10.1039/B915678J

Low Plasma Membrane Expression of the Miltefosine Transport Complex Renders Leishmania braziliensis Refractory to the Drug 10.1128/AAC.01694-08

Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets Leishmania Respiratory Complex III and Induces Apoptosis 10.1128/AAC.00790-10

Leishmania donovani Develops Resistance to Drug Combinations 10.1371/JOURNAL.PNTD.0001974

Disruption of the Lipid-Transporting LdMT-LdRos3 Complex in Leishmania donovani Affects Membrane Lipid Asymmetry but Not Host Cell Invasion 10.1371/JOURNAL.PONE.0012443

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells 10.1016/J.BCP.2010.05.017

Terpenoids from Maytenus Species and Assessment of Their Reversal Activity against a Multidrug-Resistant Leishmania tropica Line 10.1002/CBDV.201000356

Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-beta-agarofuran sesquiterpenes 10.1016/J.EJMECH.2011.07.048

The 8-Aminoquinoline Analogue Sitamaquine Causes Oxidative Stress in Leishmania donovani Promastigotes by Targeting Succinate Dehydrogenase 10.1128/AAC.00520-11

Sitamaquine Overcomes ABC-Mediated Resistance to Miltefosine and Antimony in Leishmania 10.1128/AAC.00065-11

Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry 10.1016/J.BBAMEM.2010.11.031

A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania 10.1111/J.1365-2958.2010.07531.X

Leishmanicidal and Reversal Multidrug Resistance Constituents from Aeonium lindleyi 10.1055/S-0030-1250144

Oxazolo[3,2-a]pyridine. A new structural scaffold for the reversal of multi-drug resistance in Leishmania 10.1016/J.BMCL.2012.07.100

LABCG2, a New ABC Transporter Implicated in Phosphatidylserine Exposure, Is Involved in the Infectivity and Pathogenicity of Leishmania 10.1371/JOURNAL.PNTD.0002179

Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-beta-agarofuran Sesquiterpenes from Celastrus vulcanicola 10.1021/NP500903A

A New ABC Half-Transporter in Leishmania major Is Involved in Resistance to Antimony 10.1128/AAC.00211-13

Experimental Resistance to Drug Combinations in Leishmania donovani: Metabolic and Phenotypic Adaptations 10.1128/AAC.04231-14

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit 10.1042/BJ20131318

4-Amino Bis-Pyridinium Derivatives as Novel Antileishmanial Agents 10.1128/AAC.02481-13

Mechanisms of Action of Substituted beta-Amino Alkanols on Leishmania donovani 10.1128/AAC.04003-14

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening 10.1093/JAC/DKT407

Fitness of Leishmania donovani Parasites Resistant to Drug Combinations 10.1371/JOURNAL.PNTD.0003704

Antileishmanial activity of sp(2)-iminosugar derivatives 10.1039/C5RA02627J

High-Throughput Screening Platform for Natural Product-Based Drug Discovery Against 3 Neglected Tropical Diseases: Human African Trypanosomiasis, Leishmaniasis, and Chagas Disease 10.1177/1087057114555846

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs 10.1016/J.IJPDDR.2018.04.002

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes 10.1016/J.EJMECH.2014.10.040

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum 10.1016/J.IJPDDR.2016.04.003

Functional role of highly conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase 10.1042/BCJ20170749

The LABCG2 Transporter from the Protozoan Parasite Leishmania Is Involved in Antimony Resistance 10.1128/AAC.02813-15

Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols 10.1042/BCJ20170685

Optimization by Molecular Fine Tuning of Dihydro-beta-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance 10.1021/ACS.JMEDCHEM.5B01429

Leishmania LABCG1 and LABCG2 transporters are involved in virulence and oxidative stress: functional linkage with autophagy 10.1186/S13071-017-2198-1

Mechanisms of miltefosine resistance in leishmania 10.1007/978-3-7091-1125-3_17

Carmenza Spadafora

Spadafora Carmenza

ORCID: 0000-0002-3002-9467

Email: cspadafora@indicasat.org.pa

Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf.Trichodesmiumsp. nov. 10.1021/np200611f

Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus 10.1016/j.tetlet.2011.12.021

Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins 10.1021/ol301607q

Antitrypanosomal alkaloids from the marine bacterium Bacillus pumilus 10.3390/molecules170911146

Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes 10.1016/j.molbiopara.2011.01.005

Cytotoxic Veraguamides, Alkynyl Bromide-Containing Cyclic Depsipeptides from the Marine Cyanobacterium cf.Oscillatoria margaritifera 10.1021/np200077f

Comparison of the in vitro invasive capabilities of Plasmodium falciparum schizonts isolated by Percoll gradient or using magnetic based separation 10.1186/1475-2875-10-96

Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum 10.1371/journal.ppat.1000968

Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity 10.1371/journal.pone.0084549

Erratum: Anti-malarial activity and HS-SPME-GC-MS chemical profiling of Plinia cerrocampanensis leaf essential oil (Malaria Journal (2014) 13 (235)) 10.1186/1475-2875-13-235

Chemical and bioactive natural products from microthyriaceae sp., an endophytic fungus from a tropical grass 10.1111/lam.12245

Malarial hemozoin: From target to tool 10.1016/j.bbagen.2014.02.009 Review

Bioactivity of Fungal Endophytes as a Function of Endophyte Taxonomy and the Taxonomy and Distribution of Their Host Plants 10.1371/journal.pone.0073192

Randomized, double-blinded, phase 2 trial of wr 279,396 (paromomycin and gentamicin) for cutaneous leishmaniasis in panama 10.4269/ajtmh.12-0736

Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi 10.2436/20.1501.01.139

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi 10.1016/S0166-6851(02)00156-1

Blood Stage Plasmodium falciparum Exhibits Biological Responses to Direct Current Electric Fields 10.1371/journal.pone.0161207

Volatile organic compounds associated with Plasmodium falciparum infection in vitro 10.1186/s13071-017-2157-x

Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants 10.1038/s41598-017-05515-6

Phytochemical composition, antiparasitic and α–glucosidase inhibition activities from Pelliciera rhizophorae 10.1186/s13065-015-0130-3

Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β-Amino Acids 10.1021/acs.orglett.5b03110

Dudawalamides A–D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens 10.1021/acs.jnatprod.7b00034

Malarial hemozoin: From target to tool 10.1016/j.bbagen.2014.02.009

Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice 10.1080/13880209.2016.1181659

Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine CyanobacteriumOkeania hirsuta 10.1021/acs.joc.5b01264

Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives 10.1038/s41598-017-12336-0

Pumilacidins from the octocoral-associated bacillus sp. Dt001 display anti-proliferative effects in plasmodium falciparum 10.3390/molecules23092179

Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro 10.1038/s41598-019-41697-x

Antiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected mice 10.1007/s12639-020-01207-7

Author Correction: Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro 10.1038/s41598-020-69582-y

Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi 10.3390/molecules26144217

Secondary metabolites from Panamanian mat forming cyanobacteria 10.1055/s-0032-1320708

Access and Benefit Sharing Under the Nagoya Protocol—Quo Vadis? Six Latin American Case Studies Assessing Opportunities and Risk 10.3389/fphar.2020.00765

Semisynthesis, Antiplasmodial Activity, and Mechanism of Action Studies of Isocoumarin Derivatives 10.1021/acs.jnatprod.0c01032

Extracellular Vesicles Could Carry an Evolutionary Footprint in Interkingdom Communication 10.3389/fcimb.2020.00076

Correction: Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity (PLoS ONE) 10.1371/annotation/10c47668-8c49-48d2-ba65-60420af463b6

Thermo-Energetic Study in Blood Infected with Plasmodium falciparum radiated at 2.45GHz 10.23919/EuMC.2019.8910930

Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group 10.1021/acs.jnatprod.7b00917

Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species 10.1021/acs.jnatprod.7b00367

Evaluation of antiparasitic, anticancer, antimicrobial and hypoglycemic properties of organic extracts from Panamanian mangrove plants 10.4103/1995-7645.223531

Antiparasitic compounds from the panamanian marine bacterium pseudomonas aeruginosa 10.1177/1934578X1901400109

19-Hydroxy-bufalin, a major bufadienolide isolated from the parotoid gland secretions of the Panamanian endemic toad Rhinella centralis (Bufonidae), inhibits the growth of Trypanosoma cruzi 10.1016/j.toxicon.2020.02.009

Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién 10.1371/journal.pone.0214193

Revisión de Modelos Hiperelásticos utilizados en Tejidos 10.18502/keg.v3i1.1417