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Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism

Chapuis, Julien Flaig, Amandine Grenier-Boley, Benjamin Eysert, Fanny Pottiez, Virginie Deloison, Gaspard Vandeputte, Alexandre Ayral, Anne-Marie Mendes, Tiago Desai, Shruti Goate, Alison M. Kauwe, John S. K. Leroux, Florence Herledan, Adrien Demiautte, Florie Bauer, Charlotte Checler, Frederic Petersen, Ronald C. Blennow, Kaj Zetterberg, Henrik Minthon, Lennart Van Deerlin, Vivianna M. Lee, Virginia Man-Yee Shaw, Leslie M. Trojanowski, John Q. Albert, Marilyn Moghekar, Abhay O'Brien, Richard Peskind, Elaine R. Malmanche, Nicolas Schellenberg, Gerard D. Dourlen, Pierre Song, Ok-Ryul Cruchaga, Carlos Amouyel, Philippe Deprez, Benoit Brodin, Priscille Lambert, Jean-Charles ADGC Alzheimer's Dis Neuroimaging Initi

Acta neuropathologica, 2017-6

https://doi.org/10.1007/s00401-016-1652-z

Pierre Dourlen

Dourlen Pierre

ORCID: 0000-0002-3562-1080

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina. 10.1371/journal.pgen.1007627

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. 10.1016/j.neurobiolaging.2018.08.001

Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals. 10.1007/s40142-018-0141-1

Expression of fatty acid transport protein in retinal pigment cells promotes lipid droplet expansion and photoreceptor homeostasis 10.1101/287672

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models. 10.1038/srep40764

Identification of Tau Toxicity Modifiers in the Drosophila Eye. 10.1007/978-1-4939-6598-4_26

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 10.1007/s00401-016-1652-z

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease. 10.1016/j.ebiom.2016.06.002

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. 10.1038/mp.2016.59

Fatty acid transport proteins in disease: New insights from invertebrate models. 10.1016/j.plipres.2015.08.001

Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain. 10.1186/s40478-015-0237-8

In vivo assessment of neuronal cell death in Drosophila. 10.1007/978-1-4939-2152-2_25

The Tomato/GFP-FLP/FRT method for live imaging of mosaic adult Drosophila photoreceptor cells. 10.3791/50610

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. 10.1038/mp.2013.1

TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila. 10.1016/j.celrep.2012.12.014

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker. 10.1016/j.neurobiolaging.2012.08.004

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation. 10.1038/cdd.2012.100

Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival. 10.1371/journal.pgen.1002833

Drosophila models of tauopathies: what have we learned? 10.1155/2012/970980

ER stress inhibits neuronal death by promoting autophagy. 10.4161/auto.19716

Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila. 10.1016/j.ydbio.2010.12.040

ER stress protects from retinal degeneration. 10.1038/emboj.2009.76

The peptidyl prolyl cis/trans isomerase Pin1 downregulates the Inhibitor of Apoptosis Protein Survivin. 10.1016/j.bbamcr.2007.05.012

Pin1 allows for differential Tau dephosphorylation in neuronal cells. 10.1016/j.mcn.2006.03.006

The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. 10.1074/jbc.m601849200

The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? 10.1007/s00401-019-02004-0

Pyk2 Overexpression in Postsynaptic Neurons Blocks Aβ1-42-induced Synaptotoxicity in a Microfluidic Co-Culture Model 10.1101/2019.12.20.884205

Priscille Brodin

Brodin Priscille

ORCID: 0000-0003-0991-7344

Email: priscille.brodin@inserm.fr

How can nanoparticles contribute to antituberculosis therapy? 10.1016/j.drudis.2017.01.011

Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone 10.3390/toxins9070227 10.3390/toxins9070227.

Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections 10.2217/nnm-2016-0364

Cyclodextrin-based nanocarriers containing a synergic drug combination: a potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030 10.1016/j.ijpharm.2017.05.030.

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z

Host-directed therapies offer novel opportunities for the fight against tuberculosis 10.1016/j.drudis.2017.05.005 10.1016/j.drudis.2017.05.005.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria 10.1111/mmi.13535

Impact of pe_ pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis 10.3389/fcimb.2017.00137

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis 10.1111/cmi.12619

Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129 10.1002/cyto.a.23129.

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 10.1126/science.aag1006

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters 10.1039/c5ob02630j

Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro 10.1007/s00705-016-2771-5

Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization 10.1016/j.str.2016.07.009

Mycolactone The amazing analgesic mycobacterial toxin 10.1051/medsci/20163202007

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection 10.1038/srep29297

2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 10.1021/cb5007163

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo 10.1371/journal.ppat.1004650

High content screening in chemical biology: overview and main challenges 10.1051/medsci/20153102016

High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis 10.1128/aac.03705-14

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system 10.1016/j.vaccine.2015.03.083

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro 10.3389/fmicb.2015.00438

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action 10.1128/jvi.01473-15

Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays 10.1007/978-1-4939-2450-9_24

A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening 10.3791/51114

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/jm500422b

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways 10.1016/j.cell.2014.04.040

Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro 10.1016/j.jff.2014.09.022

A novel specific edge effect correction method for RNA interference screenings 10.1093/bioinformatics/btr648

Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779

Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u

The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence 10.1371/journal.pone.0047573

Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis 10.1371/journal.pone.0026675

Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200076a

High-content screening in infectious diseases 10.1016/j.cbpa.2011.05.023

Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ 10.1099/mic.0.038133-0

High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling 10.1371/journal.ppat.1001100

High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery 10.4155/fmc.10.223

Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting 10.1016/j.biomaterials.2009.09.044

Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure 10.1177/1087057108328762

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis 10.1126/science.1171583

High Content Screening Identifies Decaprenyl-Phosphoribose 2 ' Epimerase as a Target for Intracellular Antimycobacterial Inhibitors 10.1371/journal.ppat.1000645

Systematic Genetic Nomenclature for Type VII Secretion Systems 10.1371/journal.ppat.1000507

Control of M-tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP 10.1371/journal.ppat.0040033

Aquatic insects and transmission of Mycobacterium ulcerans 10.1051/medsci/20072367572

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 10.1128/jb.00469-07

Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis 10.1371/journal.ppat.0030062

Protection against mycobacterium ulcerans lesion development by exposure to aquatic insect saliva 10.1371/journal.pmed.0040064

Support vector machines for automatic detection of tuberculosis bacteria in confocal microscopy images 10.1109/isbi.2007.356794

Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues 10.1016/j.bmc.2006.12.009

An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis 10.1128/iai.74.4.2128-2137.2006

Benzofuro 3,2-f 1 benzopyrans: A new class of antitubercular agents 10.1016/j.bmc.2006.03.033

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence 10.1128/iai.74.1.88-98.2006

High frequency of CD4(+) T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection 10.1128/iai.02086-05

Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence 10.1128/jb.00631-06

Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis 10.1016/j.tube.2004.09.009

Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity 10.1074/jbc.M503515200

Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics 10.1099/mic.0.27799-0

Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions 10.1016/j.jmb.2005.05.049

Tuberculosis: from genome to vaccine 10.1586/14760584.4.4.541

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RDI immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6 10.1128/iai.72.4.2170-2176.2004

Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens 10.1086/421468

ESAT-6 proteins: protective antigens and virulence factors? 10.1016/j.tim.2004.09.007

Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex 10.1099/mic.0.26662-0

CD8(+)-T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family 10.1128/iai.71.12.7173-7177.2003

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis 10.1038/nm859

A new evolutionary scenario for the Mycobacterium tuberculosis complex 10.1073/pnas.052548299

Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant 10.1128/iai.70.10.5568-5578.2002

Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides 10.1021/bi015732y

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti 10.1046/j.1365-2958.2002.03237.x

6-Oxocytidine containing oligonucleotides inhibit the HIV-1 integrase in vitro 10.1081/ncn-100002322

Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase 10.1021/bi000398b

Inhibition of the human immunodeficiency virus type 1 DNA integration by modified oligonucleotides 10.1023/a:1026631910681

Branched oligonucleotide-intercalator conjugate forming a parallel stranded structure inhibits HIV-1 integrase 10.1016/s0014-5793(99)01350-2

Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides 10.1080/07328319908044831

Optimization of alternate-strand triple helix formation at the 5 '-TpA-3 ' and 5 '-ApT-3 ' junctions 10.1093/nar/27.15.3029

A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus 10.1074/jbc.272.25.16010

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371

ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton 10.15252/embr.201744371 10.15252/embr.201744371.

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles 10.1038/s41598-017-05453-3

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4 10.1038/s41598-017-11843-4.

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays 10.1021/acschembio.7b00091

Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017 10.1016/j.mib.2017.11.017.

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101 10.1016/j.celrep.2017.08.101.

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids 10.1073/pnas.1707840114 10.1073/pnas.1707840114.

Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry 10.1128/jvi.01982-17

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors 10.1016/j.celrep.2018.03.125

Oxadiazolone derivatives, new promising multi-target inhibitors against M. tuberculosis 10.1016/j.bioorg.2018.08.025

Proteomics of Mycobacterium infection: Moving towards a Better Understanding of Pathogen-Driven immunomodulation 10.3389/fimmu.2018.00086

Synergy between circular bacteriocin AS-48 and ethambutol against Mycobacterium tuberculosis 10.1128/aac.00359-18

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase 10.1016/j.tube.2018.08.004

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis 10.1038/s41598-017-11843-4

Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs 10.1016/j.ijpharm.2017.05.030

Host-pathogen systems for early drug discovery against tuberculosis 10.1016/j.mib.2017.11.017

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages 10.1016/j.chom.2017.07.020

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling 10.1016/j.celrep.2017.08.101

Phenotypic assays for Mycobacterium tuberculosis infection 10.1002/cyto.a.23129

A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening 10.1002/cyto.a.20627

Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections 10.1002/ppsc.201800360

Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation 10.1074/mcp.RA119.001316

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters 10.3389/fphar.2019.00378

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis 10.1021/acsnano.8b07902

Mitochondrial Dynamics and Activity in Legionella-Infected Cells 10.1007/978-1-4939-9048-1_13

Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria 10.3389/fmicb.2018.02258

Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication 10.1128/jvi.02009-18

A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation 10.1039/C9OB00680J

Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls 10.3390/toxins11090516

Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies. 10.3389/fimmu.2020.569127

Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity. 10.1021/acsinfecdis.9b00277

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds. 10.1371/journal.pone.0227224

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis. 10.1016/j.vaccine.2019.11.085

IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551

Worms' Antimicrobial Peptides. 10.3390/md17090512

T(oo)bAd. 10.1038/s41589-019-0347-x

Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. 10.1371/journal.pone.0198226

Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. 10.1021/jm300377g

Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38

Automated HTS/HCS for antivirals using visual HIV full replication assays. 10.1186/1742-4690-6-s2-p82

Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. 10.4049/jimmunol.174.6.3570

Cell microbiology interview 10.1111/cmi.13288

Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts 10.1099/mgen.0.000505

Philippe Amouyel

Amouyel Philippe

ORCID: 0000-0001-9088-234X

Association of Alzheimer’s related genotypes with cognitive decline in multiple domains: results from the Three-City Dijon study 10.1038/mp.2015.62

How obesity relates to socio-economic status: identification of eating behavior mediators 10.1038/ijo.2016.109

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. 10.1038/s41588-018-0205-x

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium 10.1101/409649

Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes. 10.1111/jth.14279

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. 10.1038/s41380-018-0112-7

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. 10.1016/j.neurobiolaging.2018.08.001

Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases. 10.1186/s13024-018-0270-8

Associations between long-term exposure to air pollution, glycosylated hemoglobin, fasting blood glucose and diabetes mellitus in northern France. 10.1016/j.envint.2018.07.034

Determinants and outcome of multiple and early recurrent cervical artery dissections. 10.1212/wnl.0000000000006037

Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels. 10.1016/j.jacl.2018.07.012

Comparison of the rates of stroke and acute coronary events in northern France. 10.1177/2047487318788921

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION 10.1101/352674

Cost-effectiveness of optimized adherence to prevention guidelines in European patients with coronary heart disease: Results from the EUROASPIRE IV survey. 10.1016/j.ijcard.2018.06.104

Transethnic, Genome-Wide Analysis Reveals Immune-Related Risk Alleles and Phenotypic Correlates in Pediatric Steroid-Sensitive Nephrotic Syndrome. 10.1681/asn.2017111185

Analysis of shared heritability in common disorders of the brain. 10.1126/science.aap8757

Expression and Implication of Clusterin in Left Ventricular Remodeling After Myocardial Infarction. 10.1161/circheartfailure.117.004838

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. 10.1038/s41467-018-04362-x

Genetic determinants of risk and survival in pulmonary arterial hypertension 10.1101/317164

Incidence of and Risk Factors Associated With Age-Related Macular Degeneration: Four-Year Follow-up From the ALIENOR Study. 10.1001/jamaophthalmol.2018.0504

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 10.1038/s41588-018-0082-3

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 10.1038/s41588-018-0050-y

Fish Intake, Genetic Predisposition to Alzheimer Disease, and Decline in Global Cognition and Memory in 5 Cohorts of Older Persons. 10.1093/aje/kwx330

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. 10.1038/s41588-018-0084-1

Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing 10.1101/294629

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. 10.1093/ije/dyy016

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 10.1038/s41588-018-0058-3

Exhaled breath NOx levels in a middle-aged adults population-based study: reference values and association with the smoking status. 10.1016/j.rmed.2018.03.002

Sources of household air pollution: The association with lung function and respiratory symptoms in middle-aged adult. 10.1016/j.envres.2018.02.016

Sex Differences in Stroke Attack, Incidence, and Mortality Rates in Northern France. 10.1016/j.jstrokecerebrovasdis.2017.12.023

Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable. 10.1161/strokeaha.117.019309

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 10.1038/s41588-017-0011-x

Low-grade systemic inflammation: a partial mediator of the relationship between diabetes and lung function. 10.1016/j.annepidem.2017.11.004

MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure. 10.1038/s41598-017-15011-6

Exome-wide association study of plasma lipids in >300,000 individuals. 10.1038/ng.3977

Ideal Cardiovascular Health and Incident Cardiovascular Disease: Heterogeneity Across Event Subtypes and Mediating Effect of Blood Biomarkers: The PRIME Study. 10.1161/JAHA.117.006389

Genetic analysis of over one million people identifies 535 novel loci for blood pressure. 10.1101/198234

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. 10.1016/S0140-6736(17)32129-3

Determinants of social inequalities in stroke incidence across Europe: a collaborative analysis of 126 635 individuals from 48 cohort studies. 10.1136/jech-2017-209728

Genome-wide Association Study Links APOEϵ4 and BACE1 Variants with Plasma Amyloid β Levels 10.1101/194266

COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. 10.1212/wnl.0000000000004560

Changes over time in the prevalence and treatment of cardiovascular risk factors, and contributions to time trends in coronary mortality over 25 years in the Lille urban area (northern France). 10.1016/j.acvd.2017.03.009

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide 10.1101/173831

Association of impaired renal function with venous thrombosis: A genetic risk score approach. 10.1016/j.thromres.2017.08.015

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360) 10.1101/176511

Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits. 10.1016/j.clnu.2017.07.012

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 10.1038/ng.3916

Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls. 10.1016/j.neurobiolaging.2017.07.001

Tau deletion promotes brain insulin resistance. 10.1084/jem.20161731

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. 10.1038/nn.4587

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes 10.1101/144410

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. 10.1038/ncomms14774

Cervical artery dissection in patients ≥60 years: Often painless, few mechanical triggers. 10.1212/wnl.0000000000003788

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease 10.1101/110957

Integrative network analysis reveals time-dependent molecular events underlying left ventricular remodeling in post-myocardial infarction patients. 10.1016/j.bbadis.2017.02.001

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. 10.1016/j.jacc.2016.11.056

Rare and low-frequency coding variants alter human adult height. 10.1038/nature21039

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Novel genetic loci associated with hippocampal volume. 10.1038/ncomms13624

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Calibrating longitudinal cognition in Alzheimer's disease across diverse test batteries and datasets. 10.1159/000367970

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Defining the role of common variation in the genomic and biological architecture of adult human height. 10.1038/ng.3097

Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism. 10.1016/j.neurobiolaging.2014.09.001

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Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. 10.1371/journal.pgen.1004508

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A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential. 10.1182/blood-2013-10-529628

Passive smoking and smoking cessation among patients with coronary heart disease across Europe: results from the EUROASPIRE III survey. 10.1093/eurheartj/eht538

A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis. 10.1002/art.38136

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 10.1038/ng.2802

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Low-fat and high-fat dairy products are differently related to blood lipids and cardiovascular risk score. 10.1177/2047487313503283

Abdominal obesity and lower gray matter volume: a Mendelian randomization study. 10.1016/j.neurobiolaging.2013.07.022

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Circulating plasma serine208-phosphorylated troponin T levels are indicator of cardiac dysfunction. 10.1111/jcmm.12112

The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis. 10.1371/journal.pone.0065174

Depression and mortality: artifact of measurement and analysis? 10.1016/j.jad.2013.07.010

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Elevated peripheral leukocyte counts in acute cervical artery dissection. 10.1111/ene.12201

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External validation of the 2008 Framingham cardiovascular risk equation for CHD and stroke events in a European population of middle-aged men. The PRIME study. 10.1016/j.ypmed.2013.04.003

A study on the polymorphisms of the renin-angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria. 10.1177/1470320313485898

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 10.1038/ng.2606

Identification of additional proteins in differential proteomics using protein interaction networks. 10.1002/pmic.201200482

A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. 10.1186/1471-2350-14-36

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension. 10.1038/ng.2581

The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism. 10.1136/jnnp-2012-304475

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. 10.1038/mp.2013.1

Thyroid hormone receptor alpha gene variants increase the risk of developing obesity and show gene-diet interactions. 10.1038/ijo.2013.11

Multiple biomarkers for the prediction of ischemic stroke: the PRIME study. 10.1161/atvbaha.112.300109

Attainment of low-density lipoprotein cholesterol target in the French general population according to levels of cardiovascular risk: Insights from the MONA LISA study. 10.1016/j.acvd.2012.11.003

Alcohol consumption patterns and body weight. 10.1159/000342839

Ischemic stroke is associated with the ABO locus: the EuroCLOT study. 10.1002/ana.23838

Genetic and molecular insights into the role of PROX1 in glucose metabolism. 10.2337/db12-0864

Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans. 10.1161/atvbaha.112.300663

Large-scale association analysis identifies new risk loci for coronary artery disease. 10.1038/ng.2480

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. 10.1038/ng.2477

TREM2 variants in Alzheimer's disease. 10.1056/NEJMoa1211851

From genes to stroke subtypes. 10.1016/s1474-4422(12)70235-1

C-reactive protein, fibrinogen, and cardiovascular disease prediction. 10.1056/NEJMoa1107477

The major element of 1-year prognosis in acute coronary syndromes is severity of initial clinical presentation: Results from the French MONICA registries. 10.1016/j.acvd.2012.05.008

Impact of age on the importance of systolic and diastolic blood pressures for stroke risk: the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project. 10.1161/hypertensionaha.112.201400

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. 10.1038/mp.2012.75

Total ApoE and ApoE4 isoform assays in an Alzheimer's disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides. 10.1074/mcp.M112.018861

ARMS2 A69S polymorphism and the risk for age-related maculopathy: the ALIENOR study. 10.1001/archophthalmol.2012.420

Lack of association of non-synonymous FUT2 and ALPL polymorphisms with venous thrombosis. 10.1111/j.1538-7836.2012.04807.x

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Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. 10.1093/ije/dys086

Impact of REV-ERB alpha gene polymorphisms on obesity phenotypes in adult and adolescent samples. 10.1038/ijo.2012.117

Large-scale replication and heterogeneity in Parkinson disease genetic loci. 10.1212/WNL.0b013e318264e353

Relationships between chronic use of statin therapy, presentation of acute coronary syndromes and one-year mortality after an incident acute coronary event. 10.1016/j.ijcard.2012.06.112

Fruit and vegetable intake and smoking cessation. 10.1038/ejcn.2012.70

Sedentary behaviour, physical activity and dietary patterns are independently associated with the metabolic syndrome. 10.1016/j.diabet.2012.04.005

Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis. 10.1371/journal.pone.0038538

Lipid-related markers and cardiovascular disease prediction. 10.1001/jama.2012.6571

Depressive symptoms, a time-dependent risk factor for coronary heart disease and stroke in middle-aged men: the PRIME Study. 10.1161/strokeaha.111.645366

Common variants at 12q14 and 12q24 are associated with hippocampal volume. 10.1038/ng.2237

Identification of common variants associated with human hippocampal and intracranial volumes. 10.1038/ng.2250

Usefulness of circulating biomarkers for the prediction of left ventricular remodeling after myocardial infarction. 10.1016/j.amjcard.2012.02.069

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease. 10.1038/mp.2012.15

Adipocytokines and the risk of ischemic stroke: the PRIME Study. 10.1002/ana.22669

Clinical usefulness of the metabolic syndrome for the risk of coronary heart disease does not exceed the sum of its individual components in older men and women. The Three-City (3C) Study. 10.1136/heartjnl-2011-301185

Thrombolysis in cervical artery dissection--data from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) database. 10.1111/j.1468-1331.2012.03704.x

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. 10.1038/mp.2012.14

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. 10.1016/S0140-6736(11)61931-4

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. 10.1016/j.neurobiolaging.2012.02.005

Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis. 10.1136/annrheumdis-2011-200986

Single polymorphism nucleotide rs1333049 on chromosome 9p21 is associated with carotid plaques but not with common carotid intima-media thickness in older adults. A combined analysis of the Three-City and the EVA studies. 10.1016/j.atherosclerosis.2012.02.038

Interregional differences in the clinical, biological and electrical characteristics of first acute coronary events in France: results from the MONICA registries. 10.1177/2047487312438983

Do lifestyle behaviours explain socioeconomic differences in all-cause mortality, and fatal and non-fatal cardiovascular events? Evidence from middle aged men in France and Northern Ireland in the PRIME Study. 10.1016/j.ypmed.2012.01.017

Excessive daytime sleepiness and vascular events: the Three City Study. 10.1002/ana.22656

Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease. 10.1002/humu.22009

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk. 10.1186/1750-1326-7-3

The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project. 10.1016/j.numecd.2011.09.002

Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels. 10.1371/journal.pone.0029480

Quantitative mass spectrometry analysis using PAcIFIC for the identification of plasma diagnostic biomarkers for abdominal aortic aneurysm. 10.1371/journal.pone.0028698

Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk. 10.1016/j.neurobiolaging.2011.10.011

Genetics of venous thrombosis: insights from a new genome wide association study. 10.1371/journal.pone.0025581

Modifying effect of arterial hypertension on amyotrophic lateral sclerosis. 10.3109/17482968.2011.610110

A framework for quantifying net benefits of alternative prognostic models. 10.1002/sim.4362

Systemic chemokine levels, coronary heart disease, and ischemic stroke events: the PRIME study. 10.1212/WNL.0b013e31822dc7c8

Measures of abdominal adiposity and the risk of stroke: the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) study. 10.1161/strokeaha.111.614099

Blood pressure control and knowledge of target blood pressure in coronary patients across Europe: results from the EUROASPIRE III survey. 10.1097/hjh.0b013e328348efa7

Associations of complement factor H and smoking with early age-related macular degeneration: the ALIENOR study. 10.1167/iovs.10-6235

Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. 10.1371/journal.pgen.1002091

A two-stage meta-analysis identifies several new loci for Parkinson's disease. 10.1371/journal.pgen.1002142

Effects of insulin-like growth factor 1 in preventing acute coronary syndromes: the PRIME study. 10.1016/j.atherosclerosis.2011.05.034

Association between a thyroid hormone receptor-α gene polymorphism and blood pressure but not with coronary heart disease risk. 10.1038/ajh.2011.94

Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. 10.1002/ana.22403

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. 10.1161/CIRCGENETICS.110.958728

FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents. 10.3945/jn.111.140392

Regional factors interact with educational and income tax levels to influence food intake in France. 10.1038/ejcn.2011.73

APOE and Alzheimer disease: a major gene with semi-dominant inheritance. 10.1038/mp.2011.52

Could clinical decision rules relying on cardiovascular risk models increase psychosocial inequalities in health? Results from the PRIME cohort study. 10.1016/j.ypmed.2011.04.006

Contribution of lifetime smoking habit in France and Northern Ireland to country and socioeconomic differentials in mortality and cardiovascular incidence: the PRIME Study. 10.1136/jech.2010.123943

Association of plasma Aß peptides with blood pressure in the elderly. 10.1371/journal.pone.0018536

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. 10.1038/ng.803

Association of vascular risk factors with cervical artery dissection and ischemic stroke in young adults. 10.1161/circulationaha.110.000125

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. 10.1038/mp.2011.24

Independent and joint effects of the MAPT and SNCA genes in Parkinson disease. 10.1002/ana.22321

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. 10.1016/S0140-6736(11)60105-0

Genetics of Alzheimer's disease: new evidences for an old hypothesis? 10.1016/j.gde.2011.02.002

Diabetes mellitus, fasting glucose, and risk of cause-specific death. 10.1056/NEJMoa1008862

Resting heart rate, mortality and future coronary heart disease in the elderly: the 3C Study. 10.1177/1741826710389365

Effects of occupational and educational changes on obesity trends in France: the results of the MONICA-France survey 1986-2006. 10.1016/j.ypmed.2011.02.004

The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. 10.1001/archgenpsychiatry.2010.196

Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study. 10.1016/j.atherosclerosis.2011.01.031

KNG1 Ile581Thr and susceptibility to venous thrombosis. 10.1182/blood-2010-11-319053

Cardiovascular proteomics: translational studies to develop novel biomarkers in heart failure and left ventricular remodeling. 10.1002/prca.201000056

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations. 10.1016/j.neurobiolaging.2010.11.022

Study of estrogen receptor-α and receptor-β gene polymorphisms on Alzheimer's disease. 10.3233/jad-2011-110362

High blood pressure prevalence and control in a middle-aged French population and their associated factors: the MONA LISA study. 10.1097/hjh.0b013e32833f9c4d

Ten-year risk of all-cause mortality: assessment of a risk prediction algorithm in a French general population. 10.1007/s10654-010-9541-6

Strategy for purification and mass spectrometry identification of SELDI peaks corresponding to low-abundance plasma and serum proteins. 10.1016/j.jprot.2010.12.005

Characteristics of current smokers, former smokers, and second-hand exposure and evolution between 1985 and 2007. 10.1097/hjr.0b013e32833a9a0c

Patterns of alcohol consumption and ischaemic heart disease in culturally divergent countries: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). 10.1136/bmj.c6077

Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population. 10.1093/hmg/ddq497

Gender differences in the implementation of cardiovascular prevention measures after an acute coronary event. 10.1136/hrt.2010.196170

Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe). 10.1186/1471-2350-11-144

Common polymorphisms in six genes of the methyl group metabolism pathway and obesity in European adolescents. 10.3109/17477166.2010.500386

Combinatorial peptide ligand library plasma treatment: Advantages for accessing low-abundance proteins. 10.1002/elps.201000188

Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease. 10.1038/jhg.2010.92

Relative contribution of lipids and apolipoproteins to incident coronary heart disease and ischemic stroke: the PRIME Study. 10.1159/000319067

C-reactive protein, interleukin 6, fibrinogen and risk of sudden death in European middle-aged men: the PRIME study. 10.1161/atvbaha.110.208785

Profile of macrophages in human abdominal aortic aneurysms: a transcriptomic, proteomic, and antibody protein array study. 10.1021/pr100250s

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. 10.1016/S0140-6736(10)60484-9

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits. 10.3945/ajcn.2010.29422

Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies. 10.1093/ije/dyq063

Genome-wide analysis of genetic loci associated with Alzheimer disease. 10.1001/jama.2010.574

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. 10.1016/S0140-6736(10)60545-4

Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. 10.1194/jlr.M006205

Decreased serine207 phosphorylation of troponin T as a biomarker for left ventricular remodelling after myocardial infarction. 10.1093/eurheartj/ehq108

Association between the frequency of fruit and vegetable consumption and cardiovascular disease in male smokers and non-smokers. 10.1038/ejcn.2010.46

Deep plasma proteomic analysis of patients with left ventricular remodeling after a first myocardial infarction. 10.1002/prca.200900178

Disability and incident coronary heart disease in older community-dwelling adults: the Three-City Study. 10.1111/j.1532-5415.2010.02758.x

Deciphering genetic susceptibility to frontotemporal lobar dementia. 10.1038/ng0310-189

Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population. 10.1038/jhg.2010.10

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects. 10.1016/j.tig.2009.12.004

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. 10.3233/JAD-2010-100933

Is the urea cycle involved in Alzheimer's disease? 10.3233/JAD-2010-100630

Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis. 10.3233/jad-2010-100018

Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. 10.3233/jad-2010-100126

Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. 10.1002/ajmg.b.30980

Residual cardiovascular risk in treated hypertension and hyperlipidaemia: the PRIME Study. 10.1038/jhh.2009.34

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. 10.1016/j.neurobiolaging.2009.11.021

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. 10.1016/S0140-6736(09)61717-7

Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study. 10.1038/ijo.2009.260

Higher level of systemic C-reactive protein is independently predictive of coronary heart disease in older community-dwelling adults: the three-city study. 10.1111/j.1532-5415.2009.02625.x

Peroxisome proliferator-activated receptor gamma polymorphisms and coronary heart disease. 10.1155/2009/543746

Does abdominal obesity have a similar impact on cardiovascular disease and diabetes? A study of 91,246 ambulant patients in 27 European countries. 10.1093/eurheartj/ehp371

Single-nucleotide polymorphism of CD36 locus and obesity in European adolescents. 10.1038/oby.2009.412

Associations between common genetic polymorphisms in angiopoietin-like proteins 3 and 4 and lipid metabolism and adiposity in European adolescents and adults. 10.1210/jc.2009-0769

Major lipids, apolipoproteins, and risk of vascular disease. 10.1001/jama.2009.1619

A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease. 10.1016/j.neulet.2009.10.040

Breast-feeding modulates the influence of the peroxisome proliferator-activated receptor-gamma (PPARG2) Pro12Ala polymorphism on adiposity in adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study. 10.2337/dc09-1459

Adipocytokines and the risk of coronary heart disease in healthy middle aged men: the PRIME Study. 10.1038/ijo.2009.204

Respective contribution of conventional risk factors and antihypertensive treatment to stable angina pectoris and acute coronary syndrome as the first presentation of coronary heart disease: the PRIME Study. 10.1097/hjr.0b013e32832c88d1

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. 10.1038/ng.439

Association of plasma amyloid beta with risk of dementia: the prospective Three-City Study. 10.1212/wnl.0b013e3181b78448

Which measure of adiposity for primary care? 10.1111/j.1742-1241.2009.02159.x

Impact of incomplete DNase I treatment on human macrophage proteome analysis. 10.1002/prca.200900113

Fruits, vegetables and coronary heart disease. 10.1038/nrcardio.2009.131

Low plasma retinol predicts coronary events in healthy middle-aged men: the PRIME Study. 10.1016/j.atherosclerosis.2009.07.018

Association of ornithine transcarbamylase gene polymorphisms with hypertension and coronary artery vasomotion. 10.1038/ajh.2009.110

Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. 10.1001/jama.2009.1063

Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study. 10.1016/j.metabol.2009.02.019

Anthropometric assessment of abdominal obesity and coronary heart disease risk in men: the PRIME study. 10.1136/hrt.2009.171447

An age effect on the association of common variants of ACE with Alzheimer's disease. 10.1016/j.neulet.2009.06.006

CADISP-genetics: an International project searching for genetic risk factors of cervical artery dissections. 10.1111/j.1747-4949.2009.00281.x

Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study. 10.1016/j.diabet.2008.12.005

Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease. 10.1016/j.neurobiolaging.2009.04.007

Fractalkine receptor/ligand genetic variants and carotid intima-media thickness. 10.1161/strokeaha.108.537159

Contribution of cardiovascular risk factors to coronary risk in patients with intermittent claudication in the PRIME Cohort Study of European men. 10.1016/j.atherosclerosis.2009.03.025

EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries. 10.1097/hjr.0b013e3283294b1d

Systematically missing confounders in individual participant data meta-analysis of observational cohort studies. 10.1002/sim.3540

The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. 10.1002/gepi.20374

Trends in plasma lipids, lipoproteins and dyslipidaemias in French adults, 1996-2007. 10.1016/j.acvd.2009.02.002

Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure. 10.1016/j.clinbiochem.2009.03.004

Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countries. 10.1016/s0140-6736(09)60330-5

Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies. 10.1002/sim.3530

Influence of cholesteryl ester transfer protein, peroxisome proliferator-activated receptor alpha, apolipoprotein E, and apolipoprotein A-I polymorphisms on high-density lipoprotein cholesterol, apolipoprotein A-I, lipoprotein A-I, and lipoprotein A-I:A-II concentrations: the Prospective Epidemiological Study of Myocardial Infarction study. 10.1016/j.metabol.2008.09.026

Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors. 10.1002/ajmg.b.30793

Association of macronutrient intake patterns with being overweight in a population-based random sample of men in France. 10.1016/j.diabet.2008.09.006

Excessive daytime sleepiness is an independent risk indicator for cardiovascular mortality in community-dwelling elderly: the three city study. 10.1161/strokeaha.108.530824

Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. 10.1038/mp.2009.10

Study of the genetic variability of ZAC1 (PLAGL1) in French population-based samples. 10.1097/hjh.0b013e32831bc736

Measures to assess the prognostic ability of the stratified Cox proportional hazards model. 10.1002/sim.3378

Large scale association analysis of novel genetic loci for coronary artery disease. 10.1161/ATVBAHA.108.181388

In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes. 10.1016/j.ymgme.2008.11.160

Smoking habits, waist circumference and coronary artery disease risk relationship: the PRIME study. 10.1097/hjr.0b013e32830fe479

Ten-year all-cause mortality in presumably healthy subjects on lipid-lowering drugs (from the Prospective Epidemiological Study of Myocardial Infarction [PRIME] prospective cohort). 10.1016/j.amjcard.2008.09.092

Abdominal obesity is associated with ineffective control of cardiovascular risk factors in primary care in France. 10.1016/j.diabet.2008.07.001

Alzheimer disease with cerebrovascular disease and vascular dementia: clinical features and course compared with Alzheimer disease. 10.1136/jnnp.2007.137851

Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease? 10.1016/j.neulet.2008.10.081

Proteomic analysis of left ventricular remodeling in an experimental model of heart failure. 10.1021/pr800409u

The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides. 10.1186/1471-2350-9-84

Calf circumference is inversely associated with carotid plaques. 10.1161/strokeaha.108.520106

Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project. 10.1038/ejhg.2008.127

Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study. 10.1093/eurheartj/ehn331

Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction. 10.1007/s00109-008-0376-5

INR variability in atrial fibrillation: a risk model for cerebrovascular events. 10.1016/j.ejim.2008.04.005

Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease. 10.1093/hmg/ddn183

Application of saturation dye 2D-DIGE proteomics to characterize proteins modulated by oxidized low density lipoprotein treatment of human macrophages. 10.1021/pr700683s

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. 10.1016/j.cell.2008.05.048

Residential environment and blood pressure in the PRIME Study: is the association mediated by body mass index and waist circumference? 10.1097/hjh.0b013e3282fd991f

Predicting left ventricular remodeling after a first myocardial infarction by plasma proteome analysis. 10.1002/pmic.200700781

Association study of the CFH Y402H polymorphism with Alzheimer's disease. 10.1016/j.neurobiolaging.2008.03.003

Distension of the carotid artery and risk of coronary events: the three-city study. 10.1161/atvbaha.108.164582

Proteomic analysis in cardiovascular diseases. 10.1111/j.1440-1681.2008.04878.x

Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations. 10.1038/sj.ijo.0803705

Association study of the GAB2 gene with the risk of developing Alzheimer's disease. 10.1016/j.nbd.2007.12.006

An apolipoprotein A-I gene promoter polymorphism associated with cognitive decline, but not with Alzheimer's disease. 10.1159/000112176

Tea consumption is inversely associated with carotid plaques in women. 10.1161/atvbaha.107.151928

Cognitive decline and survival in Alzheimer's disease according to education level. 10.1159/000111693

Paraoxonase activity and coronary heart disease risk in healthy middle-aged males: the PRIME study. 10.1016/j.atherosclerosis.2007.08.019

Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease. 10.1038/sj.mp.4002089

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. 10.1007/s10654-007-9165-7

Recurrent in-frame insertion in C/EBPalpha TAD2 region is a polymorphism without prognostic value in AML. 10.1038/sj.leu.2404926

Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration. 10.1093/aje/kwm191

High consumptions of grain, fish, dairy products and combinations of these are associated with a low prevalence of metabolic syndrome. 10.1136/jech.2006.052126

Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events. 10.1161/atvbaha.107.150458

Genetic heterogeneity of Alzheimer's disease: complexity and advances. 10.1016/j.psyneuen.2007.05.015

Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease. 10.1016/j.neurobiolaging.2007.05.021

Low-density lipoprotein receptor-related protein 8 gene polymorphisms and dementia. 10.1016/j.neurobiolaging.2007.05.024

Depressed mood and dietary fish intake: direct relationship or indirect relationship as a result of diet and lifestyle? 10.1016/j.jad.2007.03.012

Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. 10.1093/hmg/ddm084

Type A behaviour and consumption of an atherogenic diet: no association in the PRIME study. 10.1016/j.appet.2007.03.223

A prospective evaluation of left ventricular remodeling after inaugural anterior myocardial infarction as a function of gene polymorphisms in the renin-angiotensin-aldosterone, adrenergic, and metalloproteinase systems. 10.1016/j.ahj.2007.01.009

Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness. 10.1136/jmg.2006.047449

Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly. 10.1038/sj.mp.4001974

Evidence of a role for lactadherin in Alzheimer's disease. 10.2353/ajpath.2007.060664

Variations in the APP gene promoter region and risk of Alzheimer disease. 10.1212/01.wnl.0000255938.33739.46

Bilirubin and coronary heart disease risk in the Prospective Epidemiological Study of Myocardial Infarction (PRIME). 10.1097/01.hjr.0000230097.81202.9f

A possible role for the PPARG Pro12Ala polymorphism in preterm birth. 10.2337/db06-0915

Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes. 10.1016/j.amjhyper.2006.05.018

New insight into the association of apolipoprotein E genetic variants with carotid plaques and intima-media thickness. 10.1161/01.str.0000249011.94055.00

[Coronary mortality in France according to data sources] 10.1016/s0398-7620(06)76743-8

The impact of the AMPD1 gene polymorphism on exercise capacity, other prognostic parameters, and survival in patients with stable congestive heart failure: a study in 686 consecutive patients. 10.1016/j.ahj.2006.04.003

Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. 10.1093/jn/136.10.2588

Impact of a CART promoter genetic variation on plasma lipid profile in a general population. 10.1016/j.ymgme.2006.08.012

Study of the impact of perilipin polymorphisms in a French population. 10.1186/1477-5751-5-10

Impact of the matrix metalloproteinase MMP-3 on dementia. 10.1016/j.neurobiolaging.2006.05.030

Homocysteine and coronary heart disease risk in the PRIME study. 10.1016/j.atherosclerosis.2006.05.014

Association study of the PIN1 gene with Alzheimer's disease. 10.1016/j.neulet.2006.04.010

Profiling of membrane proteins from human macrophages: comparison of two approaches. 10.1002/pmic.200500546

Independent contribution of dairy products and calcium intake to blood pressure variations at a population level. 10.1097/01.hjh.0000217849.10831.16

A study of the relationships between KLF2 polymorphisms and body weight control in a French population. 10.1186/1471-2350-7-26

The serotonin transporter promoter polymorphism and suicide. 10.1016/j.neulet.2006.02.012

Association study of the Ubiquilin gene with Alzheimer's disease. 10.1016/j.nbd.2006.01.007

Association between the metabolic syndrome and parental history of premature cardiovascular disease. 10.1093/eurheartj/ehi717

Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men. 10.1016/j.ijcard.2004.10.065

The APOA4 Thr347->Ser347 polymorphism is not a major risk factor of obesity. 10.1038/oby.2005.264

Fruit and vegetable consumption and risk of stroke: a meta-analysis of cohort studies. 10.1212/01.wnl.0000180600.09719.53

The impact of beta-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure. 10.1016/j.ejheart.2004.10.006

Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. 10.1001/jama.294.14.1799

Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women. 10.2337/diabetes.54.10.3043

A common variant of endothelial nitric oxide synthase (Glu298Asp) is associated with collateral development in patients with chronic coronary occlusions. 10.1186/1471-2261-5-27

Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease. 10.1016/j.neurobiolaging.2005.07.013

Plasma cystatin-C and development of coronary heart disease: The PRIME Study. 10.1016/j.atherosclerosis.2005.06.017

Lack of association between serological evidence of past Coxiella burnetii infection and incident ischaemic heart disease: nested case-control study. 10.1186/1471-2334-5-61

TAFI gene haplotypes, TAFI plasma levels and future risk of coronary heart disease: the PRIME Study. 10.1111/j.1538-7836.2005.01486.x

Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease? 10.1136/jnnp.2004.048983

Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. 10.1016/j.ymgme.2005.05.006

Trends in coronary heart disease in France during the second half of the 1990s. 10.1097/01.hjr.0000160603.49386.92

Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population. 10.1016/j.ymgme.2005.02.004

Fasting insulin concentrations and coronary heart disease incidence in France and Northern Ireland: the PRIME Study. 10.1016/j.ijcard.2005.04.024

Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). 10.1161/01.cir.0000164203.54111.ae

APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: the Three-City Study. 10.1212/01.wnl.0000160114.42643.31

Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure. 10.1097/01213011-200503000-00001

The proteome and secretome of human arterial smooth muscle cells. 10.1002/pmic.200400965

Household income is associated with the risk of metabolic syndrome in a sex-specific manner. 10.2337/diacare.28.2.409

Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease. 10.1159/000090362

Sex hormone-binding globulin is a major determinant of the lipid profile: the PRIME study. 10.1016/j.atherosclerosis.2004.10.029

Frequency of fruit and vegetable consumption and coronary heart disease in France and Northern Ireland: the PRIME study. 10.1079/bjn20041286

Overall alcohol intake, beer, wine, and systemic markers of inflammation in western Europe: results from three MONICA samples (Augsburg, Glasgow, Lille). 10.1016/j.ehj.2004.09.032

Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease. 10.1038/sj.mp.4001584

TLR4/Asp299Gly, CD14/C-260T, plasma levels of the soluble receptor CD14 and the risk of coronary heart disease: The PRIME Study. 10.1038/sj.ejhg.5201277

Impact of genetic variation of PPARgamma in humans. 10.1016/j.ymgme.2004.08.014

[The dawn of a new era in cardiovascular prevention]. 10.1016/s0755-4982(04)98866-5

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. 10.1016/s0140-6736(04)17103-1

Education, socioeconomic and lifestyle factors, and risk of coronary heart disease: the PRIME Study. 10.1093/ije/dyh267

Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study. 10.1097/01.hjr.0000136416.24769.42

Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study. 10.1097/01.hjh.0000133733.32125.09

Assessment of Nurr1 nucleotide variations in familial Parkinson's disease. 10.1016/j.neulet.2004.05.028

APOE promoter polymorphisms and dementia in the elderly. 10.1016/j.neulet.2004.04.063

Alcohol intake and diet in France, the prominent role of lifestyle. 10.1016/j.ehj.2003.12.022

Two-dimensional maps and databases of the human macrophage proteome and secretome. 10.1002/pmic.200300691

Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. 10.1016/j.neulet.2004.03.066

Nutritional intakes of 1072 French free-living men with and without diagnosed cardiovascular risk factors. 10.1038/sj.ejcn.1601878

Genes encoding endothelin-converting enzyme-1 and endothelin-1 interact to influence blood pressure in women: the EVA study. 10.1097/00004872-200404000-00016

Commonalities between genetics of cardiovascular disease and neurodegenerative disorders. 10.1097/00041433-200404000-00005

Prognostic impact of matrix metalloproteinase gene polymorphisms in patients with heart failure according to the aetiology of left ventricular systolic dysfunction. 10.1016/j.ehj.2004.01.015

A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population. 10.1016/j.atherosclerosis.2003.12.029

Endothelial cell markers and the risk of coronary heart disease: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study. 10.1161/01.cir.0000120705.55512.ec

Paraoxonase 1 gene polymorphisms and dementia in humans. 10.1016/j.neulet.2003.12.100

CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. 10.1002/ana.20051

Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease. 10.1136/jnnp.2003.015750

Association study of Notch 4 polymorphisms with Alzheimer's disease. 10.1136/jnnp.2003.017368

Residual coronary risk in men aged 50-59 years treated for hypertension and hyperlipidaemia in the population: the PRIME study. 10.1097/00004872-200402000-00028

Beta-adrenergic receptor blockade and the angiotensin-converting enzyme deletion polymorphism in patients with chronic heart failure. 10.1016/j.ejheart.2003.09.006

Change in cardiovascular risk factors in France, 1985-1997. 10.1023/b:ejep.0000013393.11132.e8

The association of metabolic disorders with the metabolic syndrome is different in men and women. 10.1159/000075304

Are the Framingham and PROCAM coronary heart disease risk functions applicable to different European populations? The PRIME Study. 10.1016/j.ehj.2003.09.002

Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). 10.1161/01.cir.0000099509.76044.a2

The Gly16-->Arg16 and Gln27-->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men. 10.1210/jc.2003-030173

The role of matrix metalloproteinase-9 in dementia. 10.1016/s0304-3940(03)00905-4

Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and incident coronary heart disease: the PRIME Study. 10.1016/s0021-9150(03)00280-6

Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms. 10.1186/1477-9560-1-5

Fish consumption is associated with lower heart rates. 10.1161/01.cir.0000084542.64687.97

[The OSCAR registry. Registry of acute coronary syndromes]. 10.1016/s0003-3928(03)00081-7

Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element. 10.1016/s0890-8508(03)00050-1

Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population. 10.1086/375844

Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease. 10.1136/jmg.40.6.424

C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study. 10.1161/01.atv.0000079512.66448.1d

Polymorphism of the codon 129 of the prion protein (PrP) gene and neuropathology of cerebral ageing. 10.1007/s00401-003-0700-7

Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease. 10.1038/sj.mp.4001344

Distributions of C-reactive protein measured by high-sensitivity assays in apparently healthy men and women from different populations in Europe. 10.1373/49.4.669

Body mass index, hypertension and 5-year coronary heart disease incidence in middle aged men: the PRIME study. 10.1097/01.hjh.0000052480.18130.20

Joint use of clinical parameters, biological markers and CAGE questionnaire for the identification of heavy drinkers in a large population-based sample. 10.1093/alcalc/agg051

Evolution and cost trends of antihypertensive and hypolipidaemic drug treatment in France. 10.1023/a:1025395904030

Family history, longevity, and risk of coronary heart disease: the PRIME Study. 10.1093/ije/dyg038

A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population. 10.1161/01.atv.0000051382.28752.fe

S18Y polymorphism in the UCH-L1 gene and Parkinson's disease: evidence for an age-dependent relationship. 10.1002/mds.10326

Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study. 10.1093/hmg/ddg009

Plasma fibrinogen explains much of the difference in risk of coronary heart disease between France and Northern Ireland. The PRIME study. 10.1016/s0021-9150(02)00309-x

Relevance and limitations of public databases for microarray design: a critical approach to gene predictions. 10.1038/sj.tpj.6500184

Psychosocial risk factors for heart disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). 10.1093/ije/31.6.1227

No association of the HLA-A2 allele with Alzheimer's disease. 10.1016/s0304-3940(02)01057-1

Efficacy of very low dose perindopril 2 mg/indapamide 0.625 mg combination on left ventricular hypertrophy in hypertensive patients: the P.I.C.X.E.L. study rationale and design. 10.1038/sj.jhh.1001467

Lipoprotein (a) as a predictor of coronary heart disease: the PRIME Study. 10.1016/s0021-9150(02)00026-6

Value of HDL cholesterol, apolipoprotein A-I, lipoprotein A-I, and lipoprotein A-I/A-II in prediction of coronary heart disease: the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction. 10.1161/01.atv.0000022850.59845.e0

No association of the -48CT polymorphism of the presenilin 1 gene with Alzheimer disease in a late-onset sporadic population. 10.1007/s007020200085

Contribution of APOE promoter polymorphisms to Alzheimer's disease risk. 10.1212/wnl.59.1.59

Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease. 10.1016/s0735-1097(02)01909-5

Association study of three polymorphisms of TGF-beta1 gene with Alzheimer's disease. 10.1136/jnnp.73.1.62

Genetic susceptibility to ageing-associated diseases. 10.1016/s1631-0691(02)01481-6

[Epidemiological studies on aging in France: from the PAQUID study to the Three-City study]. 10.1016/s1631-0691(02)01476-2

Significant impact of the highly informative (CA)n repeat polymorphism of the APOA-II gene on the plasma APOA-II concentrations and HDL subfractions: The ECTIM study. 10.1002/ajmg.10364

Longitudinal analysis of the effect of apolipoprotein E epsilon4 and education on cognitive performance in elderly subjects: the PAQUID study. 10.1136/jnnp.72.6.794

The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis. 10.1053/euhj.2001.2895

Awareness, treatment and control of hyperlipidaemia in middle-aged men in France and northern ireland in 1991-1993: the PRIME study. Prospective epidemiological study of myocardial infarction. 10.2143/ac.57.2.2005383

Pharmacogenomics and pharmacogenetics of neurodegenerative diseases: towards new targets. 10.1517/14622416.3.1.1

Types of alcoholic beverages and blood lipids in a French population. 10.1136/jech.56.1.24

Alzheimer disease is not associated with polymorphisms in the angiotensinogen and renin genes. 10.1002/ajmg.10044

Different alcohol drinking and blood pressure relationships in France and Northern Ireland: The PRIME Study. 10.1161/hy1101.095328

Blood lipid concentrations and risk of myocardial infarction. 10.1016/s0140-6736(01)06200-6

Myocardial infarction rates are higher on weekends than on weekdays in middle aged French men. 10.1136/heart.86.3.341

Ambulatory heart failure management in private practice in France. 10.1016/s1388-9842(01)00172-6

Relationships between alcoholic beverages and cardiovascular risk factor levels in middle-aged men, the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction Study. 10.1016/s0021-9150(00)00734-6

Polymorphisms in the insulin response element of APOC-III gene promoter influence the correlation between insulin and triglycerides or triglyceride-rich lipoproteins in humans. 10.1038/sj.ijo.0801658

Leisure-time physical activity and regular walking or cycling to work are associated with adiposity and 5 y weight gain in middle-aged men: the PRIME Study. 10.1038/sj.ijo.0801635

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The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction. 10.1016/s0735-1097(96)00535-9

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Deletion polymorphism in the gene for angiotensin- converting enzyme is a potent risk factor for myocardial infarction 10.1038/359641a0

Fanny EYSERT

EYSERT Fanny

ORCID: 0000-0001-7614-4375

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease 10.1016/j.ebiom.2016.06.002

Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z

Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner 10.1038/s41380-020-00926-w

Pyk2 overexpression in postsynaptic neurons blocks amyloid β1–42-induced synaptotoxicity in microfluidic co-cultures 10.1093/braincomms/fcaa139

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains 10.1007/s00401-020-02234-7

Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer's Disease. 10.3390/ijms21249521

Alison Goate

Goate Alison

ORCID: 0000-0002-0576-2472

http://icahn.mssm.edu/research/loeb-alzheimers/leadership

MAOA-uVNTR and early physical discipline interact to influence delinquent behavior 10.1111/j.1469-7610.2009.02196.x

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Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression 10.1038/mp.2017.44

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans 10.1111/j.1601-183X.2010.00608.x

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme 10.1002/ajmg.b.30186

Susceptibility locus for Alzheimer's disease on chromosome 10 10.1126/science.290.5500.2304

Initial genome scan of the nimh genetics initiative bipolar pedigrees: Chromosomes 1, 6, 8, 10, and 12 10.1002/(SICI)1096-8628(19970531)74:3<247::AID-AJMG3>3.0.CO;2-N

Relationship of age of first drink to child behavioral problems and family psychopathology 10.1097/01.alc.0000183190.32692.c7

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5 10.1093/hmg/ddp231

Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS) 10.1016/j.neurobiolaging.2012.02.014

Protection against Alzheimer's disease with apoE ∈2 10.1016/S0140-6736(94)92557-7

Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele 10.1038/srep34341

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Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z

Failure to replicate a protective effect of allele 2 of NACP/α- Synuclein polymorphism in Alzheimer's disease: An association study 10.1002/ana.410440223

Expression of Novel Alzheimer's Disease Risk Genes in Control and Alzheimer's Disease Brains 10.1371/journal.pone.0050976

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits 10.1038/srep18092

Joint multipoint linkage analysis of multivariate qualitative and quantitative trait. II. Alcoholism and event-related potentials 10.1086/302571

Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis 10.1371/journal.pone.0026741

Dissection of the phenotypic and genotypic associations with nicotinic dependence 10.1093/ntr/ntr231

PRESENILE DEMENTIA ASSOCIATED WITH MOSAIC TRISOMY 21 IN A PATIENT WITH A DOWN SYNDROME CHILD 10.1016/S0140-6736(89)90805-2

Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease 10.1007/s00439-003-0960-2

A regulatory variation in OPRK1, the gene encoding the κ-opioid receptor, is associated with alcohol dependence 10.1093/hmg/ddn068

A genome-wide screen for genes influencing conduct disorder 10.1038/sj.mp.4001368

The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood 10.1111/acer.13282

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death 10.1038/nm.3736

TDP-43 A315T mutation in familial motor neuron disease 10.1002/ana.21344

The Rare-Variant Generalized Disequilibrium Test for Association Analysis of Nuclear and Extended Pedigrees with Application to Alzheimer Disease WGS Data 10.1016/j.ajhg.2016.12.001

Nicotinic receptor gene variants influence susceptibility to heavy smoking 10.1158/1055-9965.EPI-08-0585

A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis 10.1073/pnas.1735338100

Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis 10.1016/j.neurobiolaging.2013.03.006

Association of GABRG3 with Alcohol Dependence 10.1097/01.ALC.0000108645.54345.98

Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk 10.1186/s13024-017-0184-x

Missense variant in TREML2 protects against Alzheimer's disease 10.1016/j.neurobiolaging.2013.12.010

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease 10.1038/ng.440

Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence 10.1002/ajmg.b.31136

Genome screen for platelet monoamine oxidase (MAO) activity 10.1002/(SICI)1096-8628(19991015)88:5<517::AID-AJMG15>3.0.CO;2-B

Genetic association of bipolar disorder with the β3 nicotinic receptor subunit gene 10.1097/YPG.0b013e32834135eb

A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele 10.1097/FPC.0b013e32835caf7d

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Aβ 42/40 ratios 10.1111/j.1471-4159.2004.02858.x

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein e ε4, and the risk of late-onset Alzheimer disease in African Americans 10.1001/jama.2013.2973

ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry 10.1038/mp.2011.124

Association of CHRM2 with IQ: Converging evidence for a gene influencing intelligence 10.1007/s10519-006-9131-2

Conserved "PAL" sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes 10.1016/j.nbd.2003.12.008

No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample 10.1002/ajmg.b.30058

Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: The Cache County Dementia Progression Study 10.1016/j.jalz.2013.02.010

A domain at the C-terminus of PS1 is required for presenilinase and γ-secretase activities 10.1111/j.1471-4159.2004.02945.x

Parkinson disease is not associated with C9ORF72 repeat expansions 10.1016/j.neurobiolaging.2012.10.001

Apolipoprotein Eε4 modifies Alzheimer's disease onset in an E280A PS1 kindred 10.1002/ana.10636

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans 10.1158/0008-5472.CAN-09-0786

Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family 10.1073/pnas.0403535101

The genetics of substance dependence 10.1146/annurev-genom-090711-163844

Pathogenic cysteine mutations affect progranulin function and production of mature granulins 10.1111/j.1471-4159.2009.06546.x

SORL1 variants across Alzheimer's disease European American cohorts 10.1038/ejhg.2016.122

A genetic variant (COMT) coding dopaminergic activity predicts personality traits in healthy elderly 10.1016/j.paid.2015.03.012

Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs 10.1186/1471-2350-10-122

Presenilin endoproteolysis is an intramolecular cleavage 10.1016/j.mcn.2004.12.012

Erratum: Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with Parkinsonism linked to chromosome 17 (Molecular and Cellular Biology (2000) 20:11 (4036-4048)) 10.1128/MCB.20.14.5360-5360.2000

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease 10.1038/ng.3043

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network 10.1002/ana.24647

Erratum: Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial (Rev. Neurol. (2013) 169 (10) (737-743)) 10.1016/j.neurol.2013.10.005

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta 10.1007/s10048-008-0150-4

Phenotypic similarities between late-onset Autosomal dominant and sporadic Alzheimer disease a single-family case-control study 10.1001/jamaneurol.2016.1236

Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families 10.1016/j.neurobiolaging.2015.08.006

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and alzheimer's disease: Evidence for γ-secretase dysfunction 10.1002/ana.22343

Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior 10.1371/journal.pone.0096753

Screening for the β-amyloid precursor protein mutation (APP717: Val → Ile) in extended pedigrees with early onset Alzheimer's disease 10.1016/0304-3940(91)90738-F

Linkage analyses of IQ in the Collaborative Study on the Genetics of Alcoholism (COGA) sample 10.1007/s10519-005-9009-8

Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts 10.1002/ajmg.b.31089

Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCAI polymorphisms 10.1186/1750-1326-2-7

Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for γ-secretase complex formation 10.1111/j.1471-4159.2006.03881.x

Copy Number Variations in 6q14.1 and 5q13.2 are Associated with Alcohol Dependence 10.1111/j.1530-0277.2012.01758.x

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease 10.1007/s00439-001-0614-1

Haplotype-based association analysis of the MAPT locus in Late Onset Alzheimer's disease 10.1186/1471-2156-8-3

Novel haplotypes in 17q21 are associated with progressive supranuclear palsy 10.1002/ana.20178

A genome screen of maximum number of drinks as an alcoholism phenotype 10.1002/1096-8628(20001009)96:5<632::AID-AJMG8>3.0.CO;2-#

Genome-wide association study reveals genetic risk underlying Parkinson's disease 10.1038/ng.487

A genome-wide association study of DSM-IV: Cannabis dependence 10.1111/j.1369-1600.2010.00255.x

A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset 10.1016/S0304-3940(97)00393-5

Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG 10.1006/nbdi.2001.0472

Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease 10.1001/archneurol.2009.269

A Systematic Single Nucleotide Polymorphism Screen to Fine-Map Alcohol Dependence Genes on Chromosome 7 Identifies Association With a Novel Susceptibility Gene ACN9 10.1016/j.biopsych.2007.11.005

Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease 10.1002/ajmg.b.31053

The aggregate effect of dopamine genes on dependence symptoms among cocaine users: Cross-validation of a candidate system scoring approach 10.1007/s10519-012-9531-4

The role of cardiovascular risk factors and stroke in familial Alzheimer disease 10.1001/jamaneurol.2016.2539

Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels 10.1001/archneurol.2010.350

Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease 10.1016/j.jalz.2015.05.020

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption 10.1097/FPC.0b013e32835c3b48

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation 10.1073/pnas.97.16.9299

Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples 10.1086/513703

Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes 10.1002/ana.24306

Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes 10.1136/jnnp.2006.109553

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No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found 10.1016/j.neulet.2004.03.070

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Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels 10.1186/s12864-016-2787-y

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Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans 10.1111/add.12478

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α-2 Macroglobulin gene and Alzheimer disease [4] 10.1038/8726

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A Tale of Two Genes: Microglial Apoe and Trem2 10.1016/j.immuni.2017.08.015

Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease 10.1002/humu.20138

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Modelling the occurrence and pathology of Alzheimer's disease 10.1016/0197-4580(89)90084-5

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Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking 10.1371/journal.pone.0033513

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Characterizing the Role of Brain Derived Neurotrophic Factor Genetic Variation in Alzheimer's Disease Neurodegeneration 10.1371/journal.pone.0076001

HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin 10.1002/ana.20963

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells 10.1016/j.stemcr.2017.06.018

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No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant 10.1016/0304-3940(95)12146-3

Genetic Heterogeneity in Alzheimer Disease and Implications for Treatment Strategies 10.1007/s11910-014-0499-8

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Increased in vivo amyloid-b42 production, exchange, and loss in presenilin mutation carriers 10.1126/scitranslmed.3005615

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Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures 10.1038/tp.2016.27

FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: A frontotemporal lobar degeneration with FUS proteinopathy 10.1007/s12031-011-9549-8

Genetic variability at the amyloid-β precursor protein locus may contribute to the risk of late-onset Alzheimer's disease 10.1016/S0304-3940(99)00417-6

VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death 10.1074/jbc.M900992200

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A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman 10.3233/JAD-131844

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GABRR1 and GABRR2, encoding the GABA-A receptor subunits ρ1 and ρ2, are associated with alcohol dependence 10.1002/ajmg.b.30995

Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis 10.1002/ajmg.b.30515

TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy 10.1007/s00401-009-0571-7

Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: Chromosomes 2, 11, 13, 14, and x 10.1002/(SICI)1096-8628(19970531)74:3<263::AID-AJMG5>3.0.CO;2-R

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Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene 10.1093/hmg/7.12.1887

Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels 10.3233/JAD-2010-091711

Coding variants in TREM2 increase risk for Alzheimer's disease 10.1093/hmg/ddu277

Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid 10.1186/s12864-016-2785-0

Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition 10.1001/archneurol.2011.845

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease 10.1186/s13073-016-0355-3

Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease 10.1016/S0140-6736(96)91140-X

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Measuring alcohol consumption for genomic meta-analyses of alcohol intake: Opportunities and challenges 10.3945/ajcn.111.015545

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging 10.1002/ana.21843

Association between GABRA1 and drinking behaviors in the Collaborative Study on the Genetics of Alcoholism sample 10.1111/j.1530-0277.2006.00136.x

Quantitative trait loci analysis of human event-related brain potentials: P3 voltage 10.1016/S0168-5597(98)00002-1

Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults 10.1038/mp.2008.81

A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks 10.1007/s00439-013-1318-z

Functional connectivity in autosomal dominant and late-onset Alzheimer disease 10.1001/jamaneurol.2014.1654

Smoking and genetic risk variation across populations of European, Asian, and African American ancestry-a meta-analysis of chromosome 15q25 10.1002/gepi.21627

Cortical Binding of Pittsburgh Compound B, an Endophenotype for Genetic Studies of Alzheimer's Disease 10.1016/j.biopsych.2009.09.012

Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms 10.1093/hmg/ddt432

Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus 10.1073/pnas.052716399

A physical map of the human APP gene in YACs 10.1007/BF00360904

Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases 10.1212/WNL.0b013e31829e6f94

TREM2 is associated with increased risk for Alzheimer's disease in African Americans 10.1186/s13024-015-0016-9

Genome-wide search for genes affecting the risk for alcohol dependence 10.1002/(SICI)1096-8628(19980508)81:3<207::AID-AJMG1>3.0.CO;2-T

Novel presenilin 1 variant (P117A) causing Alzheimer's disease in the fourth decade of life 10.1016/j.neulet.2008.04.029

Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network 10.1093/brain/awv004

A full genome scan for late onset Alzheimer's disease 10.1093/hmg/8.2.237

Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease 10.1016/j.neulet.2007.03.071

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Nathalie deboosere

deboosere Nathalie

ORCID: 0000-0002-2873-5485

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A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening. 10.3791/51114

Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces. 10.1016/j.fm.2012.04.007

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Comparison of chlorine and peroxyacetic-based disinfectant to inactivate Feline calicivirus, Murine norovirus and Hepatitis A virus on lettuce. 10.1016/j.ijfoodmicro.2011.08.011

Direct detection of highly pathogenic avian influenza A/H5N1 virus from mud specimens. 10.1016/j.jviromet.2011.06.002

Development and validation of a concentration method for the detection of influenza a viruses from large volumes of surface water. 10.1128/aem.02484-10

A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries. 10.1016/j.fm.2010.05.018

Assessment of the removal and inactivation of influenza viruses H5N1 and H1N1 by drinking water treatment. 10.1016/j.watres.2010.01.013

Intra-laboratory validation of a concentration method adapted for the enumeration of infectious F-specific RNA coliphage, enterovirus, and hepatitis A virus from inoculated leaves of salad vegetables. 10.1016/j.ijfoodmicro.2005.11.007

Modelling effect of physical and chemical parameters on heat inactivation kinetics of hepatitis A virus in a fruit model system. 10.1016/j.ijfoodmicro.2003.10.015

Host-pathogen systems for early drug discovery against tuberculosis. 10.1016/j.mib.2017.11.017

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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. 10.1126/science.aag1006

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Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 10.1007/s00401-016-1652-z

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[Mycolactone: the amazing analgesic mycobacterial toxin]. 10.1051/medsci/20163202007

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. 10.1039/c5ob02630j

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Plant extracts from Cameroonian medicinal plants strongly inhibit hepatitis C virus infection in vitro. 10.3389/fmicb.2015.00488

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system. 10.1016/j.vaccine.2015.03.083

Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo. 10.1371/journal.ppat.1004650

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Testing chemical and genetic Modulators in Mycobacterium tuberculosis infected cells using phenotypic assays. 10.1007/978-1-4939-2450-9_24

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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. 10.1038/nm.3262

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Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors. 10.1021/jm200825u

A novel specific edge effect correction method for RNA interference screenings. 10.1093/bioinformatics/btr648

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Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease. 10.1186/1753-6561-5-s1-p38

High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. 10.1371/journal.ppat.1001100

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Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ. 10.1099/mic.0.038133-0

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Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. 10.1016/j.biomaterials.2009.09.044

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Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. 10.1126/science.1171583

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Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. 10.1371/journal.ppat.0040033

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[Aquatic insects and transmission of Mycobacterium ulcerans]. 10.1051/medsci/20072367572

Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis. 10.1371/journal.ppat.0030062

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Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues. 10.1016/j.bmc.2006.12.009

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Benzofuro[3,2-f][1]benzopyrans: a new class of antitubercular agents. 10.1016/j.bmc.2006.03.033

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Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides. 10.1021/bi015732y

IRG1 controls immunometabolic host response and restricts intracellular Mycobacterium tuberculosis infection 10.1101/761551

Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology 10.1101/2021.06.30.450483

Benoit Deprez

Deprez Benoit

ORCID: 0000-0002-2777-4538

http://www.deprezlab.fr

Structure-activity relationships of imidazole-derived 2-[ N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme 10.1016/j.ejmech.2014.12.005

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis 10.1016/j.ejmech.2014.04.009

Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/s00401-016-1652-z

Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands 10.1016/j.ab.2014.02.011

Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space 10.1016/j.tetlet.2016.05.065

Access to newly functionalized imidazole derivatives: Efficient synthesis of novel 5-amino-2-thioimidazoles using propylphosphonic anhydride (®T3P) 10.1016/j.tetlet.2015.01.046

In vivo efficacy of microbiota-sensitive coatings for colon targeting: A promising tool for IBD therapy 10.1016/j.jconrel.2014.11.006

Synthesis of functionalized 2-isoxazolines as three-dimensional fragments for fragment-based drug discovery 10.1016/j.tetlet.2015.05.035

Identification of small inhibitory molecules targeting the Bfl-1 Anti-apoptotic protein that alleviates resistance to ABT-737 10.1177/1087057114534070

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease 10.1016/j.ebiom.2016.06.002

The bile acid chenodeoxycholic acid increases human brown adipose tissue activity 10.1016/j.cmet.2015.07.002

Kinetic target-guided synthesis in drug discovery and chemical biology: A comprehensive facts and figures survey 10.4155/fmc-2015-0007

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice 10.1038/ncomms9250

Mutations in residue 61 of H-Ras p21 protein influence MHC class II presentation 10.1093/intimm/7.2.269

Structural and docking studies of potent ethionamide boosters 10.1107/S0108270113028126

Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis 10.4155/FMC.14.84

Palladium-free Sonogashira-type cross-coupling reaction of bromoisoxazolines or N-alkoxyimidoyl bromides and alkynes 10.1016/j.tetlet.2016.01.070

Characterization of monoclonal antibodies by a fast and easy liquid chromatography-mass spectrometry time-of-flight analysis on culture supernatant 10.1016/j.ab.2015.08.006

Ligand efficiency driven design of new inhibitors of mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches 10.1021/jm500422b

Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group 10.1016/j.ejmech.2013.08.027

Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion 10.1038/nm.3828

Preface [Hot topic: Hit-to-Lead: Driving Forces for the Medicinal Chemist (Guest Editor: Benoit Deprez and Rebecca Deprez-Poulain)] 10.2174/1568026043451159

Trends in Hit-to-Lead: An Update 10.2174/978160805206610603010653

ChemInform Abstract: Convenient Synthesis of 4H-1,2,4-Triazole-3-thiols Using Di-2-pyridylthionocarbonate. 10.1002/chin.200809141

ChemInform Abstract: Efficient Propylphosphonic Anhydride (®T3P) Mediated Synthesis of Benzothiazoles, Benzoxazoles and Benzimidazoles. 10.1002/chin.201235137

ChemInform Abstract: Water-Based Conditions for the Microscale Parallel Synthesis of Bicyclic Lactams. 10.1002/chin.201322132

Parallel synthesis of polysubstituted tetrahydroquinolines 10.1016/s0040-4020(98)00140-9

High-Content Screening in Forward (Phenotypic Screening with Organisms) and Reverse (Structural Screening by NMR) Chemical Genetics 10.1007/978-3-642-19615-7_9

Synthetic vaccines: The mixotope strategy 10.1007/978-94-011-2264-1_339

An ADAM protein as a new actor of the APP metabolism 10.1016/j.jalz.2013.05.315

Lewis acid-induced reaction of homophthalic anhydride with imines: a convenient synthesis of trans-isoquinolonic acids 10.1016/s0040-4039(97)10742-0

The role of epitopes in selective T-cell activation 10.1016/0248-4900(92)90263-z

Long-lasting anti-viral cytotoxic T lymphocytes induced in vivo with chimeric-multirestricted lipopeptides 10.1016/0264-410x(94)00087-4

Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles {10.1038/s41598-017-05453-3}

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance {10.1021/acs.jmedchem.6b01873}

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 {10.1126/science.aag1006}

Identification of novel TACE inhibitors compatible with topical application {10.1016/j.bmc1.2017.02.035}

Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis. 10.1016/j.bmc.2017.07.054

Water-based conditions for the microscale parallel synthesis of bicyclic lactams 10.1016/j.tetlet.2012.11.082

Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/jm3003779

Drug-to-Genome-to-Drug, Step 2: Reversing Selectivity in a Series of Antiplasmodial Compounds 10.1021/jm201422e

Efficient propylphosphonic anhydride (®T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles 10.1016/j.tetlet.2012.03.007

Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200825u

Friedländer synthesis of polysubstituted quinolines and naphthyridines promoted by propylphosphonic anhydride (T3P®) under mild conditions 10.1039/c2nj21043f

Novel selective inhibitors of neutral endopeptidase: discovery by screening and hit-to-lead optimisation 10.1039/c2md00287f

Racemic and diastereoselective construction of indole alkaloids under solvent- and catalyst-free microwave-assisted Pictet-Spengler condensation 10.1039/c2gc16596a

Squaric acid is a suitable building-block in 4C-Ugi reaction: access to original bivalent compounds 10.1016/j.tetlet.2011.11.077

Stereoselective synthesis of enantiopure N-protected-3-arylpiperazines from keto-esters 10.1016/j.tetlet.2012.07.031

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands 10.1093/nar/gkr1113

Structure-Activity Relationships and Blood Distribution of Antiplasmodial Aminopeptidase-1 Inhibitors 10.1021/jm301506h

Tuberculosis: The drug development pipeline at a glance 10.1016/j.ejmech.2012.02.033

A facile and rapid synthesis of N-benzyl-2-substituted piperazines 10.1016/j.tetlet.2011.02.011

Application of Ullmann and Ullmann-Finkelstein reactions for the synthesis of N-aryl-N-(1H-pyrazol-3-yl) acetamide or N-(1-aryl-1H-pyrazol-3-yl) acetamide derivatives and pharmacological evaluation 10.1016/j.ejmech.2011.05.056

Drug to Genome to Drug: Discovery of New Antiplasmodial Compounds 10.1021/jm1014617

Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/jm200076a

MALDI imaging techniques dedicated to drug-distribution studies 10.4155/bio.11.88

Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox 10.1021/acs.jmedchem.7b01444

Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis 10.1016/j.ejmech.2018.09.038

Kinetic Target-Guided Synthesis: Reaching the Age of Maturity 10.1021/acs.jmedchem.9b01183

Discovery of novel N -phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis 10.1021/jm300377g

Rescue of nonsense mutations by amlexanox in human cells 10.1186/1750-1172-7-58

Setting up a bioluminescence resonance energy transfer high throughput screening assay to search for protein/protein interaction inhibitors in mammalian cells 10.3389/fendo.2012.00100

Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods 10.1371/journal.pcbi.1000695

Exploring drug target flexibility using in situ click chemistry: Application to a mycobacterial transcriptional regulator 10.1021/cb100177g

New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold 10.1016/j.bmcl.2010.08.108

Solvent-free microwave-assisted Meyers' lactamization 10.1039/b924111f

Synthesis of five- and six-membered lactams via solvent-free microwave Ugi reaction 10.1016/j.tetlet.2010.07.021

Ugi reaction for the synthesis of 4-aminopiperidine-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil 10.1016/j.tetlet.2010.03.120

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Fenofibrate-loaded PLGA microparticles: Effects on ischemic stroke 10.1016/j.ejps.2008.12.016

Hydroxamates: Relationships between structure and plasma stability 10.1021/jm900648x

Novel non-carboxylic acid retinoids: 1,2,4-Oxadiazol-5-one derivatives 10.1016/j.bmcl.2008.11.040

Synthetic EthR inhibitors boost antituberculous activity of ethionamide 10.1038/nm.1950

Alkylsquarates as key intermediates for the rapid preparation of original drug-inspired compounds 10.2174/138620708784246013

In silico-in vitro screening of protein-protein interactions: Towards the next generation of therapeutics 10.2174/138920108783955218

Natural compounds: Leads or ideas? Bioinspired molecules for drug discovery 10.1111/j.1747-0285.2008.00673.x

Original loading and Suzuki conditions for the solid-phase synthesis of biphenyltetrazoles. Application to the first solid-phase synthesis of irbesartan 10.1016/j.tetlet.2008.02.147

Synthesis of a 200-member library of squaric acid N-hydroxylamide amides 10.1016/j.bmcl.2008.08.025

A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening 10.1016/j.bmc.2006.10.010

A versatile solid-phase synthesis of 3-aryl-1,2,4-oxadiazolones and analogues 10.1016/j.tetlet.2006.12.050

Convenient synthesis of 4H-1,2,4-triazole-3-thiols using di-2-pyridylthionocarbonate 10.1016/j.tetlet.2007.09.094

Efficient, two-step synthesis of N-substituted nortropinone derivatives 10.1016/j.tetlet.2007.05.110

Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents 10.1021/jm061169b

PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil 10.1016/j.bmcl.2006.10.069

Synthesis of N-(iodophenyl)-amides via an unprecedented Ullmann-Finkelstein tandem reaction 10.1016/j.tetlet.2005.12.022

UFU ('Ullmann-Finkelstein-Ullmann'): a new multicomponent reaction 10.1016/j.tetlet.2006.04.041

Control of protein-protein interactions: Structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides 10.1021/jm0500119

Efficient, protection-free Suzuki-Miyaura synthesis of ortho- biphenyltetrazoles 10.1016/j.tetlet.2005.07.082

A simple reaction to produce small structurally complex and diverse molecules 10.1016/j.tetlet.2004.05.008

Facts, figures and trends in lead generation 10.2174/1568026043451168

Synthesis and structural studies of a novel scaffold for drug discovery: A 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4′-piperidine] 10.1016/j.tetlet.2003.11.079

From hit to lead. Analyzing structure-profile relationships 10.1021/jm010878g

From hit to lead. Combining two complementary methods for focused library design. Application to μ opiate ligands 10.1021/jm010877o

Parallel synthesis of 1,2,4-oxadiazoles from carboxylic acids using an improved, uronium-based, activation 10.1016/S0040-4039(00)02293-0

Parallel synthesis of a library of 1,4-Naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi 10.1016/S0960-894X(00)00056-1

Automated parallel synthesis of a tetrahydroisoquinolin-based library: Potential prolyl endopeptidase inhibitors 10.1016/S0960-894X(99)00003-7

Confronting the degeneracy of convergent combinatorial immunogens, or 'mixotopes', with the specificity of recognition of the target sequences 10.1016/S0264-410X(97)00079-0

Combinatorial chemistry: A rational approach to chemical diversity 10.1016/0223-5234(96)80441-7

Comparative efficiency of simple lipopeptide constructs for in vivo induction of virus-specific CTL 10.1016/0264-410X(95)00220-U

Monitoring of a three-step solid phase synthesis involving a Heck reaction using magic angle spinning NMR spectroscopy 10.1016/0040-4020(96)00701-6

Orthogonal combinatorial chemical libraries 10.1021/ja00124a042

Pimelautide or trimexautide as built-in adjuvants associated with an HIV- 1-derived peptide: Synthesis and in vivo induction of antibody and virus- specific cytotoxic T-lymphocyte-mediated response 10.1021/jm00003a009

florence leroux

leroux florence

ORCID: 0000-0003-0554-873X

Synthetic EthR inhibitors boost antituberculous activity of ethionamide 10.1038/NM.1950

Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods 10.1371/JOURNAL.PCBI.1000695

Synthesis of a 200-member library of squaric acid N-hydroxylamide amides (vol 18, pg 4968, 2008) 10.1016/J.BMCL.2008.08.116

New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold 10.1016/J.BMCL.2010.08.108

Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors 10.1021/JM200076A

Drug-to-Genome-to-Drug, Step 2: Reversing Selectivity in a Series of Antiplasmodial Compounds 10.1021/JM201422E

Drug to Genome to Drug: Discovery of New Antiplasmodial Compounds 10.1021/JM1014617

Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors 10.1021/JM200825U

Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis 10.1021/JM3003779

Novel selective inhibitors of neutral endopeptidase: discovery by screening and hit-to-lead optimisation 10.1039/C2MD00287F

Structure-Activity Relationships and Blood Distribution of Antiplasmodial Aminopeptidase-1 Inhibitors 10.1021/JM301506H

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis 10.1016/J.EJMECH.2014.04.009

Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis 10.4155/FMC.14.84

Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737 10.1177/1087057114534070

Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group 10.1016/J.EJMECH.2013.08.027

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches 10.1021/JM500422B

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance 10.1021/ACS.JMEDCHEM.6B01873

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme 10.1016/J.EJMECH.2014.12.005

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism 10.1007/S00401-016-1652-Z

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice 10.1038/NCOMMS9250

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease 10.1016/J.EBIOM.2016.06.002

Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity 10.1021/ACSINFECDIS.9B00277

Drug Target Engagement Using Coupled Cellular Thermal Shift Assay-Acoustic Reverse-Phase Protein Array 10.1177/2472555219897256

Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox 10.1021/ACS.JMEDCHEM.7B01444

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2 10.1016/J.EJMECH.2019.02.023

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr(348) phosphorylation 10.1007/S00401-019-02017-9

Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening 10.1016/J.EJMECH.2019.06.057

HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CYCLIC 3',5'-AMP WITH FLUORESCENCE DETECTION - VASOACTIVE INTESTINAL PEPTIDE-INDUCED MODIFICATION OF ITS CONCENTRATION IN NEUROBLASTOMA-CELLS 10.1016/0378-4347(94)80086-3

A NEW VASOACTIVE-INTESTINAL-PEPTIDE ANTAGONIST DISCRIMINATES VIP RECEPTORS ON GUINEA-PIG TRACHEA AND HUMAN NEUROBLASTOMA-CELLS 10.1016/0167-0115(94)90044-2

Tracheal Relaxant Effect of Triazine Derivatives: Correlation with Phosphodiesterase 4 Inhibitory Activity 10.1211/146080899128734613

Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes 10.1093/TOXSCI/KFG196

High-Throughput Image-Based Aggresome Quantification 10.1177/2472555220919708

Frédéric Checler

Checler Frédéric

ORCID: 0000-0003-2098-1750

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease 10.1016/j.ebiom.2016.06.002

Direct alpha-synuclein promoter transactivation by the tumor suppressor p53 10.1186/s13024-016-0079-2

Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice 10.2174/1567205013666160404120106

Intraneuronal aggregation of the beta-CTF fragment of APP (C99) induces A beta-independent lysosomal-autophagic pathology 10.1007/s00401-016-1577-6

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease 10.1007/s00018-015-1992-1

Presenilin 1 and Presenilin 2 Target gamma-Secretase Complexes to Distinct Cellular Compartments 10.1074/jbc.M115.708297

Sox2 FUNCTIONALLY INTERACTS WITH beta APP, THE beta APP INTRACELLULAR DOMAIN AND ADAM10 AT A TRANSCRIPTIONAL LEVEL IN HUMAN CELLS 10.1016/j.neuroscience.2015.11.022

Translational research on cognitive and behavioural disorders in neurological and psychiatric diseases 10.1016/j.therap.2016.01.001

Eph receptors: New players in Alzheimer's disease pathogenesis 10.1016/j.nbd.2014.08.028

Melatonin stimulates the nonamyloidogenic processing of beta APP through the positive transcriptional regulation of ADAM10 and ADAM17 10.1111/jpi.12200

Nuclear factor-kappa B regulates beta APP and beta- and gamma-secretases differently at physiological and supraphysiological A beta concentrations (vol 287, pg 24573, 2012) 10.1074/jbc.A115.333054

Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-annyloidogenic role of MT1-MMP 10.3389/tnagi.2014.00247

Experimental Storke: neurolysin back on stage 10.1111/jnc.12635

Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity 10.1038/onc.2013.124

Interplay between Parkin and p53 Governs a Physiological Homeostasis That Is Disrupted in Parkinson's Disease and Cerebral Cancer 10.1159/000354075

p53 in neurodegenerative diseases and brain cancers 10.1016/j.pharmthera.2013.11.009

Ryanodine receptors: Dual contribution to Alzheimer disease? 10.4161/chan.29000

Ryanodine receptors: physiological function and deregulation in Alzheimer disease 10.1186/1750-1326-9-21

Study on A beta 34 biology and detection in transgenic mice brains 10.1016/j.neurobiolaging.2014.01.011

The transcription factor X-box binding protein-1 in neurodegenerative diseases 10.1186/1750-1326-9-35

Visualization of Specific gamma-Secretase Complexes using Bimolecular Fluorescence Complementation 10.3233/jad-131268

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation (vol 281, pg 9824, 2006) 10.1074/jbc.A113.513903

alpha-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid beta (A beta)-associated cell death (vol 287, pg 5021, 2012) 10.1074/jbc.A111.323626

Cerebrospinal A beta 11-x and 17-x levels as indicators of mild cognitive impairment and patients' stratification in Alzheimer's disease 10.1038/tp.2013.58

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1 10.1242/jcs.127340

Further characterization of a putative serine protease contributing to the gamma-secretase cleavage of beta-amyloid precursor protein 10.1016/j.bmc.2012.11.045

N-truncated A beta peptides in complex fluids unraveled by new specific immunoassays 10.1016/j.neurobiolaging.2012.05.016

Nuclear factor-kappa B regulates beta APP and beta- and gamma-secretases differently at physiological and supraphysiological A beta concentrations (vol 287, pg 24573, 2012) 10.1074/jbc.A111.333054

Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription 10.1093/jmcb/mjt003

The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity (vol 280, pg 40624, 2005) 10.1074/jbc.A113.506069

The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein (vol 286, pg 29192, 2011) 10.1074/jbc.A113.208249

alpha-Secretase-Derived Cleavage of Cellular Prion Yields Biologically Active Catabolites with Distinct Functions 10.1159/000333804

alpha-Secretase-derived Fragment of Cellular Prion, N1, Protects against Monomeric and Oligomeric Amyloid beta (A beta)-associated Cell Death 10.1074/jbc.M111.323626

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and beta-amyloid production in Alzheimer's disease 10.1186/1750-1326-7-52

Evidence that the Amyloid-beta Protein Precursor Intracellular Domain, AICD, Derives From beta-Secretase-Generated C-Terminal Fragment 10.3233/jad-2012-112186

Journal of Neurochemistry special issue on Alzheimer's disease: amyloid cascade hypothesis-20 years on Preface 10.1111/j.1471-4159.2011.07603.x

Lysosomal Dysfunction in a Mouse Model of Sandhoff Disease Leads to Accumulation of Ganglioside-Bound Amyloid-beta Peptide 10.1523/jneurosci.4860-11.2012

Nuclear Factor-kappa B Regulates beta APP and beta- and gamma-Secretases Differently at Physiological and Supraphysiological A beta Concentrations 10.1074/jbc.M111.333054

p53, a Pivotal Effector of a Functional Cross-Talk Linking Presenilins and Pen-2 10.1159/000332935

Parkin: Much More than a Simple Ubiquitin Ligase 10.1159/000332803

Ryanodine Receptor Blockade Reduces Amyloid-beta Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease 10.1523/jneurosci.0875-12.2012

The beta-Secretase-Derived C-Terminal Fragment of beta APP, C99, But Not A beta, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus 10.1523/jneurosci.2775-12.2012

The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production 10.1038/cdd.2012.55

The physiology of the beta-amyloid precursor protein intracellular domain AICD 10.1111/j.1471-4159.2011.07475.x

Two-steps control of cellular prion physiology by the extracellular regulated kinase-1 (ERK1) 10.4161/pri.6.1.18004

Apoptosis in Parkinson's disease: Is p53 the missing link between genetic and sporadic Parkinsonism? 10.1016/j.cellsig.2010.10.020

ERK1-independent alpha-secretase cut of beta-amyloid precursor protein via M1 muscarinic receptors and PKC alpha/epsilon 10.1016/j.mcn.2011.04.008

ERK1-independent alpha-secretase cut of beta-amyloid precursor protein via M1 muscarinic receptors and PKC alpha/epsilon (vol 47, pg 223, 2011) 10.1016/j.mcn.2011.08.001

gamma-Secretase-Mediated Regulation of Neprilysin: Influence of Cell Density and Aging and Modulation by Imatinib 10.3233/jad-2011-110746

p53, a Molecular Bridge Between Alzheimer's Disease Pathology and Cancers? 10.1007/978-3-642-16602-0_8

The Extracellular Regulated Kinase-1 (ERK1) Controls Regulated alpha-Secretase-mediated Processing, Promoter Transactivation, and mRNA Levels of the Cellular Prion Protein 10.1074/jbc.M110.208249

Days to Criterion as an Indicator of Toxicity Associated with Human Alzheimer Amyloid-beta Oligomers 10.1002/ana.22052

Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6 10.1038/cdd.2009.116

p53 Is Regulated by and Regulates Members of the gamma-Secretase Complex 10.1159/000283483

Production and Catabolism of Amyloid Peptides in Alzheimer's Disease 10.2515/therapie/2010053

Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide 10.1111/j.1471-4159.2009.05950.x

Amyloid-beta 42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis 10.1007/s00401-009-0511-6

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes 10.1074/jbc.M109.000067

p53-Dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex 10.1111/j.1471-4159.2009.05952.x

p53-dependent control of transactivation of the Pen2 promoter by presenilins 10.1242/jcs.051169

p53-Dependent Transcriptional Control of Cellular Prion by Presenilins 10.1523/jneurosci.0789-09.2009

Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity 10.1111/j.1471-4159.2009.06131.x

The alpha-Secretase-derived N-terminal Product of Cellular Prion, N1, Displays Neuroprotective Function in Vitro and in Vivo 10.1074/jbc.M109.051086

TMP21 Transmembrane Domain Regulates gamma-Secretase Cleavage 10.1074/jbc.M109.059345

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease 10.1038/ncb1981

Isoform-specific contribution of protein kinase C to prion processing 10.1016/j.mcn.2008.07.013

NF kappa B-dependent control of BACE1 promoter transactivation by A beta 42 10.1074/jbc.M706579200

Physiological processing of the cellular prion protein and beta APP: Enzymes and regulation 10.1007/978-0-387-72076-0_32

Production and fate of amyloid peptides: Recent advances and perspectives 10.2174/156720508783954794

Regulation of beta APP and PrPc cleavage by alpha-secretase: Mechanistic and therapeutic perspectives 10.2174/156720508783954749

TMP21 regulates A beta production but does not affect caspase-3, p53, and neprilysin 10.1016/j.bbrc.2008.03.151

A novel function of parkin as a transcriptional repressor of the oncogene p53 and its impairment by familial associated Parkinson's disease mutations 10.1016/s1353-8020(08)70601-1

DJ-1 regulation of p53 pathway and its impairment by Parkinson's disease-associated mutations 10.1016/s1353-8020(08)70604-7

M-1 and M-3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity 10.1523/jneurosci.5293-06.2007

p53-dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity 10.1074/jbc.M611572200

Response to correspondence: Pardossi-Piquard et al., "Presenilin-dependent transcriptional control of the A beta-degrading enzyme neprilysin by intracellular domains of PAPP and APLP." - Neuron-46, 541-554 10.1016/j.neuron.2007.01.024

Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2 10.1159/000101840

The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation 10.1074/jbc.M609663200

The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53 10.2174/156720507781788945

6-hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation 10.1074/jbc.M513903200

APP epsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages 10.1111/j.1471-4159.2006.03748.x

Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway 10.1074/jbc.M508619200

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins 10.1042/bj20051197

Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase 10.1016/j.bbrc.2006.06.065

Neprilysin activity and expression are controlled by nicastrin 10.1111/j.1471-4159.2006.03822.x

New functions for presenilins: do they identify novel therapeutic targets? 10.1016/s0924-977x(06)70113-4

Phenotype associated with APP duplication in five families 10.1093/brain/awl237

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease 10.1523/jneurosci.0651-06.2006

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity 10.1038/nature04667

Combined pharmacological, mutational and cell biology approaches indicate that p53-dependent caspase 3 activation triggered by cellular prion is dependent on its endocytosis 10.1111/j.1471-4159.2004.02989.x

Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1 10.1038/sj.bjp.0706183

Intracellular A beta 42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease 10.1096/fj.04-2637fje

Presenilin-dependent transcriptional control of the A beta-degrading enzyme neprilysin by intracellular domains of beta APP and APLP 10.1016/j.neuron.2005.04.008

The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity 10.1074/jbc.M506069200

APH-1 and PEN-2: A study on their proteolysis 10.1016/s0197-4580(04)80522-0

Gamma-secretase inhibitors: A critical evaluation of their potential therapeutic use in Alzheimer disease 10.1016/s0197-4580(04)81875-x

Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia 10.1007/s00401-004-0826-2

Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells 10.1111/j.1471-4159.2004.02512.x

Primary cultured neurons devoid of cellular prion display lower responsiveness to Staurosporine through the control of p53 at both transcriptional and post-transcriptional levels 10.1074/jbc.M310453200

Role of nicastrin in programmed cell death 10.1016/s0197-4580(04)80271-9

BACE1- and BACE2-expressing human cells - Characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors 10.1074/jbc.M302622200

beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation - Cross-talk with alpha-synuclein and implication for Parkinson's disease 10.1074/jbc.M306083200

C-terminal fragments of amyloid-beta peptide cause cholinergic axonal degeneration by a toxic effect rather than by physical injury in the nondemented human brain 10.1023/a:1022813104905

Cellular prion protein sensitizes neurons to apoptotic stimuli through Mdm2-regulated and p53-dependent caspase 3-like activation 10.1074/jbc.M211580200

Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans 10.1016/s0304-3940(03)00339-2

JLK isocoumarin inhibitors: Selective gamma-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo 10.1002/jnr.10747

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease 10.1016/s0968-0896(03)00235-9

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart 10.1074/jbc.M212379200

Variability and heterogeneity in Alzheimer's disease with cotton wool plaques: a clinicopathological study of four autopsy cases 10.1007/s00401-003-0737-7

alpha-Synuclein lowers p53-dependent apoptotic response of neuronal cells - Abolishment by 6-hydroxydopamine and implication for Parkinson's disease 10.1074/jbc.M207825200

Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators 10.1016/s0166-2236(02)02263-4

Amyloid peptide precursor' metabolism and presenilins 10.1051/medsci/20021867717

Amyloid precursor protein, presenilins, and alpha-synuclein: Molecular pathogenesis and pharmacological applications in Alzheimer's disease 10.1124/pr.54.3.469

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase - Response 10.1038/ncb0502-e110c

gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells 10.1006/bbrc.2002.6349

Human amyloid-beta causes changes in the levels of endothelial protein kinase C and its alpha isoform in vitro 10.1016/s0197-0186(02)00026-8

Murine T cells expressing high activity of prolyl endopeptidase are susceptible to activation-induced cell death 10.1016/s0014-5793(02)02249-4

NACP/alpha-Synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases 10.1007/s0041-002-0596-7

Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies 10.1046/j.1471-4159.2002.01234.x

Potential external source of A beta in biological samples - Reply 10.1038/ncb0702-e165

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons 10.1073/pnas.062059899

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons (vol 99, pg 4043, 2002) 10.1073/pnas.122187899

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10 10.1046/j.1471-4159.2001.00180.x

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts 10.1038/ncb1101-1030

New protease inhibitors prevent gamma-secretase-mediated production of A beta 40/42 without affecting Notch cleavage 10.1038/35074581

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect A beta secretion and APP C-terminal fragment stability 10.1093/hmg/10.16.1665

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding - The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production 10.1074/jbc.M009899200

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase 10.1046/j.0014-2956.2001.02465.x

The caspase-derived C-terminal fragment of beta APP induces caspase-independent toxicity and triggers selective increase of A beta 42 in mammalian cells 10.1046/j.1471-4159.2001.00513.x

The multiple paradoxes of presenilins 10.1046/j.1471-4159.2001.00244.x

Wild-type and mutated nicastrins do not display aminopeptidase M- and B-like activities 10.1006/bbrc.2001.6030

alpha-Synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells 10.1016/s0304-3940(00)01049-1

Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice 10.1073/pnas.97.10.5346

Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation 10.1006/nbdi.1999.0272

Immunohistochemical analysis of cerebral cortical and vascular lesions in the primate Microcebus murinus reveal distinct amyloid beta 1-42 and beta 1-40 immunoreactivity profiles 10.1006/nbdi.1999.0270

Intraneuronal A beta 42 accumulation in human brain 10.1016/s0002-9440(10)64700-1

Laminar specific loss of isocortical presenilin 1 immunoreactivity in Alzheimer's disease. Correlations with the amyloid load and the density of tau-positive neurofibrillary tangles 10.1046/j.1365-2990.2000.026002117.x

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide A beta 42 in late compartments of the constitutive secretory pathway 10.1046/j.1471-4159.2000.0741878.x

Novel proline endopeptidase inhibitors do not modify A beta 40/42 formation and degradation by human cells expressing wild-type and Swedish mutated beta-amyloid precursor protein 10.1038/sj.bjp.0703440

Overexpression of Rab11 or constitutively active Rab11 does not affect sAPP alpha and A beta secretions by wild-type and Swedish mutated beta APP-expressing HEK293 cells 10.1006/bbrc.2000.3404

Phorbol ester-regulated cleavage of normal prion protein in HEK293 human cells and murine neurons 10.1074/jbc.M004628200

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons 10.1016/s0002-9440(10)64644-5

Role of the proteasome in Alzheimer's disease 10.1016/s0925-4439(00)00039-9

Vascular and parenchymal A beta deposition in the aging dog: correlation with behavior 10.1016/s0197-4580(00)00113-5

Wild-type but not Parkinson's disease-related Ala-53 -> Thr mutant alpha-synuclein protects neuronal cells from apoptotic stimuli 10.1074/jbc.M002413200

Confocal microscopy reveals thimet oligopeptidase (EC 3.4.24.15) and neurolysin (EC 3.4.24.16) in the classical secretory pathway 10.1089/104454999315385

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain 10.1074/jbc.274.10.6483

Effect of protein kinase A inhibitors on the production of A beta 40 and A beta 42 by human cells expressing normal and Alzheimer's disease-linked mutated beta APP and presenilin 1 10.1038/sj.bjp.0702406

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides 10.1073/pnas.96.2.742

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency 10.1073/pnas.96.21.11872

Presenilins - Structural aspects and posttranslational events 10.1007/bf02821716

Presenilins: Multifunctional proteins involved in Alzheimer's disease pathology 10.1080/152165499307396

S17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase 10.1006/bbrc.1999.0366

The mystery of presenilins. The research winner by KO? 10.1016/s0764-4469(99)00102-x

Unusual phenotypic alteration of beta amyloid precursor protein (beta APP) maturation by a new Val-715 -> Met beta APP-770 mutation responsible for probable early-onset Alzheimer's disease 10.1073/pnas.96.7.4119

Alzheimer's disease-linked mutation of presenilin 2 (N1411-PS2) drastically lowers APP alpha secretion: Control by the proteasome 10.1006/bbrc.1998.9619

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides 10.1038/nm0498-447

Neuropathology of preclinical and clinical late-onset Alzheimer's disease 10.1002/ana.410430519

Neuropeptide specificity and inhibition of recombinant isoforms of the endopeptidase 3.4.24.16 family: Comparison with the related recombinant endopeptidase 3.4.24.15 10.1006/bbrc.1998.8941

Cathepsin D displays in vitro beta-secretase-like specificity 10.1016/s0006-8993(96)01330-3

Contribution of endopeptidase 3.4.24.15 to central neurotensin inactivation 10.1016/s0014-2999(97)01209-0

Effect of a novel selective and potent phosphinic peptide inhibitor of endopeptidase 3.4.24.16 on neurotensin-induced analgesia and neuronal inactivation 10.1038/sj.bjp.0701182

Examination of the role of endopeptidase 3.4.24.15 in A beta secretion by human transfected cells 10.1038/sj.bjp.0701151

Purification and characterization of human endopeptidase 3.4.24.16. Comparison with the porcine counterpart indicates a unique cleavage site on neurotensin 10.1016/0006-8993(95)01260-5

NEUROTENSIN AND NEUROMEDIN-N UNDERGO DISTINCT CATABOLIC PROCESSES IN MURINE ASTROCYTES AND PRIMARY CULTURED NEURONS 10.1111/j.1432-1033.1994.tb18741.x

A SURVEY OF THE CEREBRAL REGIONALIZATION AND ONTOGENY OF 8 EXOPEPTIDASES AND ENDOPEPTIDASES IN MURINES 10.1016/0196-9781(93)90150-f

DIFFERENTIAL CATABOLIC FATE OF NEUROMEDIN-N AND NEUROTENSIN IN THE CANINE INTESTINAL-MUCOSA 10.1016/0196-9781(93)90132-z

RAT-KIDNEY ENDOPEPTIDASE-24.16 - PURIFICATION, PHYSICOCHEMICAL CHARACTERISTICS AND DIFFERENTIAL SPECIFICITY TOWARDS OPIATES, TACHYKININS AND NEUROTENSIN-RELATED PEPTIDES 10.1111/j.1432-1033.1993.tb19872.x

SYNTHESIS AND ANALGESIC EFFECTS OF N- 3- (HYDROXYAMINO)CARBONYL -1-OXO-2(R)-BENZYLPROPYL -L-ISOLEUCYL-L-LEU CINE, A NEW POTENT INHIBITOR OF MULTIPLE NEUROTENSIN NEUROMEDIN-N DEGRADING ENZYMES 10.1021/jm00062a009

ENDOPEPTIDASE 24-16 IN MURINES - TISSUE DISTRIBUTION, CEREBRAL REGIONALIZATION, AND ONTOGENY 10.1111/j.1471-4159.1992.tb11021.x

LIGHT AND ELECTRON-MICROSCOPIC LOCALIZATION OF THE NEUTRAL METALLOENDOPEPTIDASE-EC-3.4.24.16 IN THE MESENCEPHALON OF THE RAT 10.1111/j.1460-9568.1992.tb00156.x

NEUROTENSIN AND NEUROMEDIN-N UNDERGO DISTINCT PROTEOLYTIC INACTIVATION IN VENTRAL TEGMENTAL AREA AND NUCLEUS-ACCUMBENS 10.1111/j.1749-6632.1992.tb27366.x

NEUROTENSIN RECEPTOR LOCALIZATION ON NEURONS BEARING THE NEUROTENSIN-DEGRADING ENZYME ENDOPEPTIDASE-24-16 10.1111/j.1749-6632.1992.tb27365.x

NEUROTENSIN AND NEUROMEDIN-N ARE DIFFERENTLY METABOLIZED IN VENTRAL TEGMENTAL AREA AND NUCLEUS-ACCUMBENS 10.1111/j.1471-4159.1991.tb11428.x

SPECIFIC-INHIBITION OF ENDOPEPTIDASE-24.16 BY DIPEPTIDES 10.1111/j.1432-1033.1991.tb16372.x

MONOCLONAL-ANTIBODIES ALLOW PRECIPITATION OF ESTERASIC BUT NOT PEPTIDASIC ACTIVITIES ASSOCIATED WITH BUTYRYLCHOLINESTERASE 10.1111/j.1471-4159.1990.tb04555.x

NONCHOLINERGIC ACTIONS OF ACETYLCHOLINESTERASES - A GENUINE PEPTIDASE FUNCTION OR CONTAMINATING PROTEASES 10.1016/0968-0004(90)90070-r

NEUROPEPTIDE-HYDROLYZING ACTIVITIES IN SYNAPTOSOMAL FRACTIONS FROM DOG ILEUM MYENTERIC, DEEP MUSCULAR AND SUBMUCOUS PLEXUSES - THEIR PARTICIPATION IN NEUROTENSIN INACTIVATION 10.1016/0196-9781(89)90190-3

PEPTIDASIC ACTIVITIES ASSOCIATED WITH ACETYLCHOLINESTERASE ARE DUE TO CONTAMINATING ENZYMES 10.1111/j.1471-4159.1989.tb11793.x

FURTHER CHARACTERIZATION OF A NEUROTENSIN-DEGRADING NEUTRAL METALLOENDOPEPTIDASE FROM RAT-BRAIN 10.1016/0197-0186(88)90174-x

NEUROTENSIN METABOLISM IN VARIOUS TISSUES OF CENTRAL AND PERIPHERAL ORIGINS - UBIQUITOUS INVOLVEMENT OF A NOVEL NEUROTENSIN DEGRADING METALLOENDOPEPTIDASE 10.1016/0300-9084(88)90161-7

PERIPHERAL INACTIVATION OF NEUROTENSIN - ISOLATION AND CHARACTERIZATION OF A METALLOPEPTIDASE FROM RAT ILEUM 10.1111/j.1432-1033.1988.tb14220.x

NEUROTENSIN-METABOLIZING PEPTIDASES IN RAT FUNDUS PLASMA-MEMBRANES 10.1111/j.1471-4159.1987.tb02893.x

PEPTIDASES IN DOG-ILEUM CIRCULAR AND LONGITUDINAL SMOOTH-MUSCLE PLASMA-MEMBRANES - THEIR RELATIVE CONTRIBUTION TO THE METABOLISM OF NEUROTENSIN 10.1111/j.1432-1033.1987.tb13538.x

CATABOLISM OF NEUROTENSIN BY NEURAL (NEUROBLASTOMA CLONE N1E115) AND EXTRANEURAL (HT29) CELL-LINES 10.1016/0196-9781(86)90136-1

HIGH-AFFINITY RECEPTOR-SITES AND RAPID PROTEOLYTIC INACTIVATION OF NEUROTENSIN IN PRIMARY CULTURED NEURONS 10.1111/j.1471-4159.1986.tb13083.x

NEUROMEDIN-N - HIGH-AFFINITY INTERACTION WITH BRAIN NEUROTENSIN RECEPTORS AND RAPID INACTIVATION BY BRAIN SYNAPTIC PEPTIDASES 10.1016/0014-2999(86)90053-1

INACTIVATION OF NEUROTENSIN BY RAT-BRAIN SYNAPTIC-MEMBRANES PARTLY OCCURS THROUGH CLEAVAGE AT THE ARG8-ARG9 PEPTIDE-BOND BY A METALLOENDOPEPTIDASE 10.1111/j.1471-4159.1985.tb07220.x

REGULATION OF CYCLIC-GMP LEVELS BY NEUROTENSIN IN NEURO-BLASTOMA CLONE N1E115 10.1016/0006-291x(85)91411-1

COMPARISON OF SOME BIOLOGICAL PROPERTIES OF NEUROTENSIN AND ITS NATURAL ANALOG LANT-6 10.1016/0014-2999(84)90147-x

INACTIVATION OF NEUROTENSIN BY RAT-BRAIN SYNAPTIC-MEMBRANES - CLEAVAGE AT THE PRO10-TYR11 BOND BY ENDOPEPTIDASE-24.11 (ENKEPHALINASE) AND A PEPTIDASE DIFFERENT FROM PROLINE-ENDOPEPTIDASE 10.1111/j.1471-4159.1984.tb05386.x

LOSS OF HIGH-AFFINITY NEUROTENSIN RECEPTORS IN SUBSTANTIA NIGRA FROM PARKINSONIAN SUBJECTS 10.1016/s0006-291x(84)80381-2

DEGRADATION OF NEUROTENSIN BY RAT-BRAIN SYNAPTIC-MEMBRANES - INVOLVEMENT OF A THERMOLYSIN-LIKE METALLOENDOPEPTIDASE (ENKEPHALINASE), ANGIOTENSIN-CONVERTING ENZYME, AND OTHER UNIDENTIFIED PEPTIDASES 10.1111/j.1471-4159.1983.tb04753.x

RADIOLABELED NEUROTENSIN ANALOGS .2. TRITIUM LABELED NEUROTENSIN PREPARED FROM SYNTHETIC DEHYDRONEUROTENSIN 10.1016/s0300-9084(83)80105-9

DEGRADATION OF NEUROTENSIN BY BRAIN SYNAPTIC-MEMBRANES 10.1111/j.1749-6632.1982.tb31598.x

MONOIODO-TRP11-NEUROTENSIN, A NEW LIGAND TO STUDY THE INTERACTION OF NEUROTENSIN WITH ITS RECEPTOR 10.1111/j.1749-6632.1982.tb31608.x

TRP11 -NEUROTENSIN AND XENOPSIN DISCRIMINATE BETWEEN RAT AND GUINEA-PIG NEUROTENSIN RECEPTORS 10.1016/0024-3205(82)90089-3

INSULIN STIMULATION OF AMINO-ACID-TRANSPORT IN PRIMARY CULTURED RAT HEPATOCYTES VARIES IN DIRECT PROPORTION TO INSULIN BINDING 10.1016/0014-5793(81)80108-1

Chronic fornix deep brain stimulation in a transgenic Alzheimer's rat model reduces amyloid burden, inflammation, and neuronal loss. 10.1007/s00429-018-1779-x

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking. 10.1096/fj.201801076r

Neurolysin: From Initial Detection to Latest Advances. 10.1007/s11064-018-2624-6

Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease? 10.1074/jbc.r118.003999

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice. 10.1016/j.neurobiolaging.2018.06.038

Nuclear TP53: An unraveled function as transcriptional repressor of PINK1. 10.1080/15548627.2018.1450022

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. 10.1038/s41418-017-0016-0

Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases. 10.1080/15548627.2017.1363950

Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits. 10.1007/s00401-017-1733-7

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor. 10.1074/jbc.M116.743070

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models. 10.1016/j.biopsych.2017.04.011

α-synuclein and p53 functional interplay in physiopathological contexts. 10.18632/oncotarget.14385

The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing α-Secretase Activities. 10.1371/journal.pone.0170360

The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease. 10.2119/molmed.2016.00229

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes. 10.3233/JAD-160953

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 10.1007/s00401-016-1652-z

Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1. 10.1038/srep37436

The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model. 10.1038/mp.2016.152

The Transcription Factor Function of Parkin: Breaking the Dogma. 10.3389/fnins.2018.00965

The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again. 10.3390/cancers11020250

Does intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein trigger early neurotoxicity in Alzheimer's disease? 10.2174/1567205016666190325092841

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson’s Disease Physiopathology 10.3390/cells9112495

Alterations of the Endoplasmic Reticulum (ER) Calcium Signaling Molecular Components in Alzheimer’s Disease 10.3390/cells9122577

Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer’s Disease 10.3390/ijms21249521

Jean-Charles Lambert

Lambert Jean-Charles

ORCID: 0000-0003-0829-7817

ABCA7 rare variants and Alzheimer disease risk 10.1212/wnl.0000000000002627

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease 10.1016/j.ebiom.2016.06.002

Apolipoprotein E (APOE) epsilon 4 and episodic memory decline in Alzheimer's disease: A review 10.1016/j.arr.2016.02.002

Epidemiology of dementia in Central Africa (EPIDEMCA): protocol for a multicentre population-based study in rural and urban areas of the Central African Republic and the Republic of Congo (vol 3, pg 338, 2014) 10.1186/s40064-016-2094-8

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease 10.3233/JAD-150749

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology 10.1038/mp.2016.59

miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer's disease 10.1186/s13195-016-0186-x

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease 10.1016/j.ajhg.2016.05.014

Mutation in the 3 ' untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy 10.1038/ejhg.2015.61

SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease 10.1038/mp.2015.121

Common polygenic variation enhances risk prediction for Alzheimer's disease 10.1093/brain/awv268

Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism 10.1016/j.neurobiolaging.2014.09.001

Plasma amyloid-beta and risk of Alzheimer's disease in the Framingham Heart Study 10.1016/j.jalz.2014.07.001

Plasma beta-amyloid 40 levels are positively associated with mortality risks in the elderly 10.1016/j.jalz.2014.04.515

PLD3 and sporadic Alzheimer's disease risk 10.1038/nature14036

Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain 10.1186/s40478-015-0237-8

A genome-wide association meta-analysis of plasma A beta peptides concentrations in the elderly 10.1038/mp.2013.185

Abdominal obesity and lower gray matter volume: a Mendelian randomization study 10.1016/j.neurobiolaging.2013.07.022

Genome-wide association interaction analysis for Alzheimer's disease 10.1016/j.neurobiolaging.2014.05.014

MicroRNAs targeting Nicastrin regulate A beta production and are affected by target site polymorphisms 10.3389/fnmol.2014.00067

Missense variant in TREML2 protects against Alzheimer's disease 10.1016/j.neurobiolaging.2013.12.010

A Genome-Wide Association Study for Venous Thromboembolism: The Extended Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium 10.1002/gepi.21731

A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis 10.1186/1471-2350-14-36

A Regulatory Variant in CCR6 Is Associated With Susceptibility to Antitopoisomerase-Positive Systemic Sclerosis 10.1002/art.38136

Association of HDL-Related Loci with Age-Related Macular Degeneration and Plasma Lutein and Zeaxanthin: the Alienor Study 10.1371/journal.pone.0079848

From Genetics to Dietetics: The Contribution of Epidemiology to Understanding Alzheimer's Disease 10.3233/JAD-2012-129019

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension 10.1038/ng.2581

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease 10.1038/mp.2012.14

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology 10.1038/mp.2013.1

Plasma Amyloid-beta Levels and Prognosis in Incident Dementia Cases of the 3-City Study 10.3233/JAD-2012-121147

TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila 10.1016/j.celrep.2012.12.014

The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism 10.1136/jnnp-2012-304475

TREM2 Variants in Alzheimer's Disease 10.1056/NEJMoa1211851

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites 10.1038/mp.2011.24

Association between Parkinson's disease and the HLA-DRB1 locus 10.1002/mds.25035

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk 10.1186/1750-1326-7-3

Caution in Interpreting Results from Imputation Analysis When Linkage Disequilibrium Extends over a Large Distance: A Case Study on Venous Thrombosi 10.1371/journal.pone.0038538

Common variants at 12q14 and 12q24 are associated with hippocampal volume 10.1038/ng.2237

Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis 10.1136/annrheumdis-2011-200986

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus 10.1016/j.neurobiolaging.2012.02.005

Genome-wide and gene-based association implicates FRMD6 in alzheimer disease 10.1002/humu.22009

Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk 10.1016/j.neurobiolaging.2011.10.011

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease 10.1038/mp.2012.15

Total ApoE and ApoE4 Isoform Assays in an Alzheimer's Disease Case-control Study by Targeted Mass Spectrometry (n=669): A Pilot Assay for Methionine-containing Proteotypic Peptides 10.1074/mcp.M112.018861

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease 10.1016/j.neurobiolaging.2009.11.021

APOE and Alzheimer disease: a major gene with semi-dominant inheritance 10.1038/mp.2011.52

Association between IgM Anti-Herpes Simplex Virus and Plasma Amyloid-Beta Levels 10.1371/journal.pone.0029480

Association of Plasma A beta Peptides with Blood Pressure in the Elderly 10.1371/journal.pone.0018536

Associations of Complement Factor H and Smoking with Early Age-Related Macular Degeneration: The ALIENOR Study 10.1167/iovs.10-6235

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations 10.1016/j.neurobiolaging.2010.11.022

Genetics of Alzheimer's disease: new evidences for an old hypothesis? 10.1016/j.gde.2011.02.002

Genetics of Venous Thrombosis: Insights from a New Genome Wide Association Study 10.1371/journal.pone.0025581

Genome-Wide Association Studies of Cerebral White Matter Lesion Burden: The CHARGE Consortium 10.1002/ana.22403

Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population 10.1093/hmg/ddq497

Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB As Novel Risk Loci for Systemic Sclerosis 10.1371/journal.pgen.1002091

Independent and Joint Effects of the MAPT and SNCA Genes in Parkinson Disease 10.1002/ana.22321

KNG1 Ile581Thr and susceptibility to venous thrombosis 10.1182/blood-2010-11-319053

Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease 10.1016/j.neurobiolaging.2011.05.024

Study of Estrogen Receptor-alpha and Receptor-beta Gene Polymorphisms on Alzheimer's Disease 10.3233/JAD-2011-110362

Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease 10.1016/j.neurobiolaging.2009.04.007

The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels 10.1001/archgenpsychiatry.2010.196

A study of the association between the ADAM 12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease 10.1016/j.neulet.2009.10.040

Association study of the CFH Y402H polymorphism with Alzheimer's disease 10.1016/j.neurobiolaging.2008.03.003

Deciphering genetic susceptibility to frontotemporal lobar dementia 10.1038/ng0310-189

Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease 10.1038/jhg.2010.92

Implication of the Immune System in Alzheimer's Disease: Evidence from Genome-Wide Pathway Analysis 10.3233/JAD-2010-100018

Is the Urea Cycle Involved in Alzheimer's Disease? 10.3233/JAD-2010-100630

Non-Replication of Association for Six Polymorphisms From Meta-Analysis of Genome-Wide Association Studies of Parkinson's Disease: Large-Scale Collaborative Study 10.1002/ajmg.b.30980

Systematic Analysis of Candidate Genes for Alzheimer's Disease in a French, Genome-Wide Association Study 10.3233/JAD-2010-100126

The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study 10.3233/JAD-2010-100933

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects 10.1016/j.tig.2009.12.004

Association of Ornithine Transcarbamylase Gene Polymorphisms With Hypertension and Coronary Artery Vasomotion 10.1038/ajh.2009.110

Association of plasma amyloid beta with risk of dementia The prospective Three-City Study 10.1212/WNL.0b013e3181b78448

Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease 10.1016/j.neurobiolaging.2007.05.021

Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease 10.1038/sj.mp.4002089

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease 10.1038/ng.439

Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease? 10.1016/j.neulet.2008.10.081

Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease 10.1038/mp.2009.10

A polymorphism in CALHM1 influences Ca2+ homeostasis, A beta levels, and Alzheimer's disease risk 10.1016/j.cell.2008.05.048

Association study of the GAB2 gene with the risk of developing Alzheimer's disease 10.1016/j.nbd.2007.12.006

Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease 10.1093/hmg/ddn183

Deletion of the progranulin gene in patients with frontotemporal lobar degeneration or Parkinson disease 10.1016/j.nbd.2008.03.004

Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study 10.1093/brain/awn012

Evidence for the association of the S100 beta gene with low cognitive performance and dementia in the elderly 10.1038/sj.mp.4001974

Evidence of a role for lactadherin in Alzheimer's disease 10.2353/ajpath.2007.060664

Genetic heterogeneity of Azheimer's disease: Complexity and advances 10.1016/j.psyneuen.2007.05.015

Variations in the APP gene promoter region and risk of Alzheimer disease 10.1212/01.wnl.0000255938.33739.46

A 3 '-UTR polymorphism in the oxidized LDL receptor 1 gene increases A beta(40) load as cerebral amyloid angiopathy in Alzheimer's disease 10.1007/s00401-005-1108-3

Association study of the PIN1 gene with Alzheimer's disease 10.1016/j.neulet.2006.04.010

Association study of the ubiquilin gene with Alzheimer's disease 10.1016/j.nbd.2006.01.007

Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease 10.1016/j.neurobiolaging.2005.07.013

Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease 10.1001/jama.296.6.661

New insight into the association of apolipoprotein E genetic variants with carotid plaques and intima-media thickness 10.1161/01.STR.0000249011.94055.00

Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease 10.1016/j.neulet.2005.03.016

Cholesterol 25-Hydroxylase on Chromosome 10q Is a Susceptibility Gene for Sporadic Alzheimer's Disease 10.1159/000090362

Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease? 10.1136/jnnp.2004.048983

A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease 10.1136/jnnp.2003.030866

A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease 10.1016/j.neulet.2003.09.072

APOE promoter polymorphisms and dementia in the elderly 10.1016/j.neulet.2004.04.063

Association study of Notch 4 polymorphisms with Alzheimer's disease 10.1136/jnnp.2003.017368

Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population 10.1016/j.neulet.2004.03.066

Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease 10.1016/j.neulet.2004.03.008

The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease 10.1136/jmg.2003.005033

Association of 3 '-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease 10.1136/jmg.40.6.424

Relevance and limitations of public databases for microarray design: a critical approach to gene predictions 10.1038/sj.tpj.6500184

A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain 10.1016/S0304-3940(02)00190-8

Association study of three polymorphisms of TGF-beta 1 gene with Alzheimer's disease 10.1136/jnnp.73.1.62

No association of the HLA-A2 allele with Alzheimer's disease 10.1016/S0304-3940(02)01057-1

No association of the-48CT polymorphism of the presenilin 1 gene with Alzheimer disease in a late-onset sporadic population 10.1007/s007020200085

The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease 10.1016/S0304-3940(02)00553-0

Are the estrogen receptors involved in Alzheimer's disease? 10.1016/S0304-3940(01)01806-7

Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease 10.1016/S0140-6736(00)04063-0

Neuropathological epidemiology of cerebral aging: a study of two genetic polymorphisms 10.1016/S0197-4580(00)00227-X

The-48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased A beta load in brain 10.1136/jmg.38.6.353

A FE65 polymorphism associated with risk of developing sporadic late-onset Alzheimer's disease but not with A beta loading in brains 10.1016/S0304-3940(00)01477-4

Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations - the ECTIM Study 10.1093/hmg/9.1.57

A new GTP-cyclohydrolase I mutation in an unusual dopa-responsive dystonia, familial form 10.1097/00001756-199902250-00008

A novel presenilin-2 splice variant in human Alzheimer's disease brain tissue 10.1046/j.1471-4159.1999.0722498.x

Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease 10.1007/s004390050980

Is the LDL receptor-related protein involved in Alzheimer's disease? 10.1007/s100480050061

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease 10.1016/S0304-3940(99)00035-X

A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's Disease 10.1093/hmg/7.3.533

Association at LRP gene locus with sporadic late-onset Alzheimer's disease 10.1016/S0140-6736(05)78749-3

Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease 10.1093/hmg/7.9.1511

Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease 10.1016/S0304-3940(97)00304-2

Distortion of allelic expression of apolipoprotein E in Alzheimer's disease 10.1093/hmg/6.12.2151

Analysis of the APOE alleles impact in Down's syndrome 10.1016/S0304-3940(96)13244-4

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 10.1038/ng.3916

Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls. 10.1016/j.neurobiolaging.2017.07.001

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. 10.1038/nn.4587

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. 10.1038/srep45040

Regulation of the Interaction between the neuronal BIN1 isoform 1 and Tau proteins: role of the SH3 domain. 10.1111/febs.14185

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models. 10.1038/srep40764

17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression. 10.1038/mp.2016.226

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 10.1007/s00401-016-1652-z

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. 10.1038/s41380-018-0112-7

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. 10.1016/j.neurobiolaging.2018.08.001

Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals. 10.1007/s40142-018-0141-1

Incidence of and Risk Factors Associated With Age-Related Macular Degeneration: Four-Year Follow-up From the ALIENOR Study. 10.1001/jamaophthalmol.2018.0504

Voxel-Based Statistical Analysis of 3D Immunostained Tissue Imaging. 10.3389/fnins.2018.00754

Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation. 10.3389/fnmol.2018.00421

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 10.1038/s41588-019-0358-2

Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease. 10.1038/s41398-019-0394-9

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation. 10.1007/s00401-019-02017-9

The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis? 10.1007/s00401-019-02004-0

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. 10.1001/jamaneurol.2019.1456

HENA, heterogeneous network-based data set for Alzheimer's disease. 10.1038/s41597-019-0152-0

High-Content Screening for Protein-Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neurons. 10.1002/cpcb.100

Genetics of Alzheimer's disease: where we are, and where we are going. 10.1016/j.conb.2019.11.024

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment. 10.1007/s00401-020-02138-6

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study. 10.1016/s1474-4422(20)30273-8

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner. 10.1038/s41380-020-00926-w

Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains. 10.1038/s41514-020-00052-5

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis. 10.18632/aging.202950

Apolipoprotein E ϵ4 allele and neuropsychiatric symptoms among older adults in Central Africa (EPIDEMCA study). 10.1017/s1041610220003993

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. 10.1038/s41467-021-22491-8

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants. 10.1002/alz.12333

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. 10.1126/sciadv.abe8349

Pyk2 overexpression in postsynaptic neurons blocks amyloid β_1-42-induced synaptotoxicity in microfluidic co-cultures. 10.1093/braincomms/fcaa139

Carlos Cruchaga

Cruchaga Carlos

ORCID: 0000-0002-0276-2899

https://neurogenomics.wustl.edu/

The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease 10.1016/j.neurobiolaging.2014.12.007

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity 10.1371/journal.pone.0111899

Alzheimer's disease genetics: From the bench to the clinic 10.1016/j.neuron.2014.05.041

Missense variant in TREML2 protects against Alzheimer's disease 10.1016/j.neurobiolaging.2013.12.010

Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid 10.1016/j.biopsych.2013.11.032

TMEM106B: A strong FTLD disease modifier 10.1007/s00401-014-1249-3

The epigenetic landscape of Alzheimer's disease 10.1038/nn.3792

Frontobasal gray matter loss is associated with the TREM2 p.R47H variant 10.1016/j.neurobiolaging.2014.06.007

Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis 10.1371/journal.pmed.1001713

TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis 10.1001/jamaneurol.2013.6237

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease 10.1038/nature12825

Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease 10.1016/j.neurobiolaging.2014.03.004

Identification of rare variants in Alzheimer's disease 10.3389/fgene.2014.00369

Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: The Cache County Dementia Progression Study 10.1016/j.jalz.2013.02.010

Coding variants in TREM2 increase risk for Alzheimer's disease 10.1093/hmg/ddu277

Novel progranulin variants do not disrupt progranulin secretion and cleavage 10.1016/j.neurobiolaging.2013.05.004

Genetic high throughput screening in Retinitis Pigmentosa based on high resolution melting (HRM) analysis 10.1016/j.exer.2013.10.011

TREM2 and neurodegenerative disease 10.1056/NEJMc1306509

Characterizing the Role of Brain Derived Neurotrophic Factor Genetic Variation in Alzheimer's Disease Neurodegeneration 10.1371/journal.pone.0076001

Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis 10.1016/j.neurobiolaging.2013.03.006

The PSEN1, p.E318G Variant Increases the Risk of Alzheimer's Disease in APOE-ε4 Carriers 10.1371/journal.pgen.1003685

TREM2 is associated with the risk of Alzheimer's disease in Spanish population 10.1016/j.neurobiolaging.2012.12.018

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093)) 10.1038/ng0613-712a

C9orf72 hexanucleotide repeat expansions in clinical alzheimer disease 10.1001/2013.jamaneurol.537

Parkinson disease is not associated with C9ORF72 repeat expansions 10.1016/j.neurobiolaging.2012.10.001

GWAS of cerebrospinal fluid tau levels identifies risk variants for alzheimer's disease 10.1016/j.neuron.2013.02.026

TREM2 variants in Alzheimer's disease 10.1056/NEJMoa1211851

Expression of Novel Alzheimer's Disease Risk Genes in Control and Alzheimer's Disease Brains 10.1371/journal.pone.0050976

Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort 10.1186/alzrt137

Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis 10.1074/jbc.M112.389098

Cerebrospinal fluid APOE levels: An endophenotype for genetic studies for Alzheimer's disease 10.1093/hmg/dds296

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease 10.3233/JAD-2011-110824

Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families 10.1371/journal.pone.0031039

Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis 10.1371/journal.pone.0026741

Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease 10.1001/archneurol.2011.155

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance 10.1126/scitranslmed.3002156

Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels 10.1001/archneurol.2010.350

Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy 10.1016/j.neurobiolaging.2009.09.011